Personnel Information

写真a

OKUNO Keisuke


Job title

Assistant Professor

Birth date

1985
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Campus Career 【 display / non-display 】

  • 2015.04
    -
    2017.10
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Gastrointestinal Surgery， Graduate Student
  • 2017.11
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    2019.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Science and Technology， Graduate Student
  • 2020.04
    -
    2021.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Departments of Surgery， Gastric Surgery， Assistant Professor
  • 2020.04
    -
    Now
    Institute of Science Tokyo， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Systemic Organ Regulation， Department of Gastrointestinal Surgery， Assistant Professor
  • 2023.04
    -
    2023.07
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of General Surgery， Gastric Surgery， Assistant Professor
  • 2023.08
    -
    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Gastrointestinal Surgery， Assistant Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Systemic Organ Regulation， Department of Gastrointestinal Surgery， Assistant Professor

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Published Papers & Misc 【 display / non-display 】

  1. Kenta Yao, Keisuke Okuno, Shuichi Watanabe, Takashi Shigeno, Taichi Ogo, Hisashi Fujiwara, Toshiro Tanioka, Kenro Kawada, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa. A Novel Transcriptomic Signature for Prediction of Response to Adjuvant Chemotherapy in Patients With Stages II and III Gastric Cancer Annals of surgical oncology. 2025.09; 32 (9): 7014-7024.

  2. Toshiro Tanioka, Keisuke Okuno, Masanori Tokunaga, Yusuke Kinugasa . Small bowel perforation into the retro-rectus space following eTEP Rives-Stoppa repair for incisional hernia: a rare and life-threatening complication Hernia : the journal of hernias and abdominal wall surgery. 2025.07; 9;29 (1): 223.

  3. Toshiro Tanioka, Keisuke Okuno, Takashi Shigeno, Taichi Ogo, Hisashi Fujiwara, Kenro Kawada, Masanori Tokunaga, Yusuke Kinugasa. First Robotic Inguinal Hernia Repair Using the Saroa Surgical System With Force Feedback Asian journal of endoscopic surgery. 2025.07; 18 (1): e70129.

  4. Jun Sakuma, Akihiro Hoshino, Hisashi Fujiwara, Taichi Ogou, Kenro Kawada, Keisuke Okuno, Toshiro Tanioka, Shigeo Haruki, Masanori Tokunaga, Yusuke Kinugasa. Blood flow assessment of gastric tube with indocyanine green fluorescence angiography and postoperative endoscopy during esophagectomy: indocyanine green enhancement time indicated congestion BMC gastroenterology. 2024.09; 24 (1): 316. ( DOI )

  5. Y Yatabe, T Tanioka, Y Waseda, K Yamaguchi, T Ogo, H Fujiwar, K Okuno, K Kawada, S Haruki, M Tokunaga, Y Fujii, Y Kinugasa. Inguinal hernia repair in patients with artificial urinary sphincter after radical prostatectomy Hernia. 2024.08; 28 (4): 1331-1336. ( DOI )

  6. Keisuke Okuno, Shuichi Watanabe, Hoon Hur, Jeeyun Lee, Joon Oh Park, Masanori Tokunaga, Minoru Tanabe, Yusuke Kinugasa, Ajay Goel. An exosome-based liquid biopsy signature for therapeutic response prediction in metastatic gastric cancer Clinical and translational medicine. 2024.07; 14 (7): e1629. ( DOI )

  7. Keisuke Okuno, Muhammad Yogi Pratama, Jiang Li, Masanori Tokunaga, Xin Wang, Yusuke Kinugasa, Ajay Goel. Ginseng mediates its anti-cancer activity by inhibiting the expression of DNMTs and reactivating methylation-silenced genes in colorectal cancer Carcinogenesis. 2023.08; 10;44 (5): 394-403. ( PubMed, DOI )

  8. Keisuke Okuno, Shuichi Watanabe, Souvick Roy, Mitsuro Kanda, Masanori Tokunaga, Yasuhiro Kodera, Yusuke Kinugasa, Ajay Goel. A liquid biopsy signature for predicting early recurrence in patients with gastric cancer. Br J Cancer. 2023.04; 128 (6): 1105-1116. ( DOI )

  9. Ryosuke Fukuyo, Masanori Tokunaga, Yuya Umebayashi, Toshifumi Saito, Keisuke Okuno, Yuya Sato, Katsumasa Saito, Naoto Fujiwara, Yusuke Kinugasa. Deep learning-based diagnostic model for predicting complications after gastrectomy Asian journal of endoscopic surgery. 2023.04; 16 (2): 210-217. ( DOI )

  10. Keisuke Okuno, Masanori Tokunaga, Daniel Von Hoff, Yusuke Kinugasa, Ajay Goel; The PDAC Biomarker Working Group. Intratumoral Malassezia globosa Levels Predict Survival and Therapeutic Response to Adjuvant Chemotherapy in Patients With Pancreatic Ductal Adenocarcinoma Gastroenterology. 2023.04; Online ahead of print ( PubMed, DOI )

  11. Keisuke Okuno, Caiming Xu, Silvia Pascual-Sabater, Masanori Tokunaga, Tetsuji Takayama, Haiyong Han, Cristina Fillat, Yusuke Kinugasa, Ajay Goel. Andrographis Reverses Gemcitabine Resistance through Regulation of ERBB3 and Calcium Signaling Pathway in Pancreatic Ductal Adenocarcinoma. Biomedicines. 2023.01; 11 (1): ( DOI )

  12. Keisuke Okuno, Raju Kandimalla, Marta Mendiola, Francesc Balaguer, Luis Bujanda, Carlos Fernandez-Martos, Jorge Aparicio, Jaime Feliu, Masanori Tokunaga, Yusuke Kinugasa, Joan Maurel, Ajay Goel. A microRNA signature for risk-stratification and response prediction to FOLFOX-based adjuvant therapy in stage II and III colorectal cancer. Mol Cancer. 2023.01; 22 (1): 13. ( DOI )

  13. Keisuke Okuno, Caiming Xu, Silvia Pascual-Sabater, Masanori Tokunaga, Haiyong Han, Cristina Fillat, Yusuke Kinugasa, Ajay Goel. Berberine Overcomes Gemcitabine-Associated Chemoresistance through Regulation of Rap1/PI3K-Akt Signaling in Pancreatic Ductal Adenocarcinoma. Pharmaceuticals (Basel). 2022.09; 15 (10): ( DOI )

  14. Yuya Sato, Jun Sese, Takatoshi Matsuyama, Masaki Onuki, Shogo Mase, Keisuke Okuno, Katsumasa Saito, Naoto Fujiwara, Akihiro Hoshino, Kenro Kawada, Masanori Tokunaga, Yusuke Kinugasa. Preliminary study for developing a navigation system for gastric cancer surgery using artificial intelligence Surgery today. 2022.05; Online ahead of print ( DOI )

  15. Keisuke Okuno, Masanori Tokunaga, Yusuke Kinugasa, Hideo Baba, Yasuhiro Kodera, Ajay Goel. A Transcriptomic Liquid Biopsy Assay for Predicting Resistance to Neoadjuvant Therapy in Esophageal Squamous Cell Carcinoma Annals of surgery. 2022.05; Online ahead of print ( DOI )

  16. Keisuke Okuno, Rachana Garg, Yate-Ching Yuan, Masanori Tokunaga, Yusuke Kinugasa, Ajay Goel. Berberine and Oligomeric Proanthocyanidins Exhibit Synergistic Efficacy Through Regulation of PI3K-Akt Signaling Pathway in Colorectal Cancer Frontiers in oncology. 2022.05; 12:855860（eCollection 2022） ( DOI )

  17. Sono Ito, Naoto Fujiwara, Yuichiro Kume, Fumio Tsukamoto, Katsumasa Saito, Akihiro Hoshino, Kenro Kawada, Takuya Okada, Keisuke Okuno, Yuya Sato, Takatoshi Matsuyama, Masanori Tokunaga, Yusuke Kinugasa . Mucosal Congestion on the First Day Following Endoscopy Predicts Anastomotic Stricture After Esophagectomy World journal of surgery. 2022.03; 46 (3): 631-638. ( DOI )

  18. Kei Nakajima, Masanori Tokunaga, Keisuke Okuno, Katsumasa Saito, Naoto Fujiwara, Yuya Sato, Akihiro Hoshino, Takatoshi Matsuyama, Yusuke Kinugasa. Prognostic Value of Intraoperative Blood Transfusion in Patients with Adenocarcinoma of the Esophagogastric Junction Medicina (Kaunas, Lithuania) . 2022.03; 58 (4): 474. ( DOI )

  19. Okuno Keisuke, Tokunaga Masanori, Yamashita Yamato, Umebayashi Yuya, Saito Toshifumi, Fukuyo Ryosuke, Sato Yuya, Saito Katsumasa, Fujiwara Naoto, Hoshino Akihiro, Kawada Kenro, Matsuyama Takatoshi, Kinugasa Yusuke. Preoperative lymphocyte-to-monocyte ratio is the most predictive inflammatory response marker of survival in gastric cancer LANGENBECKS ARCHIVES OF SURGERY. 2021.11; 406 (7): 2287-2294. ( DOI )

  20. Okuno Keisuke, Tokunaga Masanori, Yamashita Yamato, Umebayashi Yuya, Saito Toshifumi, Fukuyo Ryosuke, Sato Yuya, Saito Katsumasa, Fujiwara Naoto, Hoshino Akihiro, Kawada Kenro, Matsuyama Takatoshi, Kinugasa Yusuke. Impact of Preoperative Time Interval on Survival in Patients With Gastric Cancer WORLD JOURNAL OF SURGERY. 2021.09; 45 (9): 2860-2867. ( DOI )

  21. Tanioka T, Kojima K, Saito T, Kanemoto E, Okuno K, Gokita K, Kobayashi K, Nakagawa M, Inokuchi M. Intraoperative Body Fluid Amylase as a Novel Indicator of Postgastrectomy Pancreatic Fistula. World Journal of Surgery. 2019.03; Epub ahead ( PubMed, DOI )

  22. Keisuke Okuno, Masatoshi Nakagawa, Kazuyuki Kojima, Emi Kanemoto, Kentaro Gokita, Toshiro Tanioka, Mikito Inokuchi. Long-term functional outcomes of Roux-en-Y versus Billroth I reconstructions after laparoscopic distal gastrectomy for gastric cancer: a propensity-score matching analysis. Surg Endosc. 2018.04; ( PubMed, DOI )

  23. Mikito Inokuchi，Masatoshi Nakagawa，Toshiro Tanioka，Keisuke Okuno1，Kentaro Gokita，Kazuyuki Kojima. Long- and short-term outcomes of laparoscopic gastrectomy versus open gastrectomy in patients with clinically and pathological locally advanced gastric cancer: a propensityscore matching analysis Surgical Endoscopy. 2017.07; published　online ( PubMed, DOI )

  24. Keisuke Okuno, Kentaro Gokita, Toshiro Tanioka, Norihito Ogawa, Sho Otsuki, Mikito Inokuch, Toshio Takayama, Kazuyuki Kojima. Esophagojejunostomy Using the Purse-String Suturing Device After Laparoscopic Total or Proximal Gastrectomy for Gastric Cancer World J Surg. 2017.04; published　online ( PubMed, DOI )

  25. Tomoki Aburatani, Kazuyuki Kojima, Sho Otsuki Hideaki Murase ,Keisuke Okuno ,Kentaro Gokita ,Chiharu Tomi, Toshiro Tanioka, Mikito Inokuchi. Double-tract reconstruction after laparoscopic proximal gastrectomy using detachable ENDO-PSD Surg Endosc. 2017.04; published　online ( PubMed, DOI )

  26. Inokuchi M, Otsuki S, Ogawa N, Tanioka T, Okuno K, Gokita K, Kawano T, Kojima K. Postoperative Complications of Laparoscopic Total Gastrectomy versus Open Total Gastrectomy for Gastric Cancer in a Meta-Analysis of High-Quality Case-Controlled Studies Gastroenterol Res Pract. 2016.11; Published online 2617903. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Keisuke Okuno, Adwait Joshi, Shuichi Watanabe, Sakiko Asano, Masanori Tokunaga, Yusuke Kinugasa. DNA methylation-based liquid biopsy model for the identification of lymph node metastasis in patients with early gastric cancer. SSO2025(Society of Surgical Oncology)　Annual Meeting 2025.03.28 FLORIDA

  2. Toshiro Tanioka, Takashi Shigeno, Yudai Kawamura, Keisuke Okuno, Taichi Ogo, Kenro Kawada, Hisashi Fujiwara, Masanori Tokunaga, Keisuke Kinugasa. The enhanced view totally extraperitoneal approach (eTEP) for midline ventral hernia repair. World Congress of Abdominal Wall Hernia Surgery 2024.10.11 Singapore

  3. Takashi Shigeno, Keisuke Okuno, Taichi Ogo, Hisashi Fujiwara, Toshiro Tanioka, Kenro Kawada, Shigeo Haruki, Masanori Tokunaga, Kiyohide Fushimi, Yusuke Kinugasa. Efficacy of intraoperative recurrent laryngeal nerve monitoring during minimally invasive esophagectomy for esophageal cancer: A nationwide inpatient cohort study. 20th ISDE World Congress for Esophageal Diseases 2024.09.22 Edinburgh

  4. Toshiro Tanioka, Keisuke Okuno, Masanori Tokunaga. Current status and future perspective of clinical trials in Japan. Academic Conference on Laparoscopic Gastric Cancer Surgery and the6th LEAPS 2024.09.07 Guandong, China

  5. Toshiro Tanioka, Takashi Shigeno, Yudai Kawamura, Keisuke Okuno, Taichi Ogo, Kenro Kawada, Hisashi Fujiwara, Masanori Tokunaga, Yusuke Kinugasa. Short-and Mid-Term outcomes after enhanced view totally extraperitoneal approach (eTEP) for primary ventral and incisional hernia repair. 18th Congress of the KHS & 2024 International Symposium 2024.07.05 Seoul

  6. 奥野圭祐、谷岡利朗、小郷泰一、藤原尚志、川田研郎、春木茂男、徳永正則、絹笠祐介. 術前臨床学的因子を用いた、胃癌に対するロボット支援胃切除術の手術合併症予測モデルの開発. 第96回日本胃癌学会総会 2024.03.01 京都

  7. Toshiro Tanioka, Ayumi Takaoka, Keisuke Okuno, Megumi Sasaki, Taichi Ogo, Marie Hanaoka, Hisashi Fujiwara, Kenro Kawada, Shigeo Haruki, Masanori Tokunaga, Yusuke Kinugasa. Enhanced view totally extraperitoneal approach (eTEP) for ventral and incisional hernia repair. 18th Annual International Congress of the Asia Pacific Hernia Society 2023 (APHS2023) 2023.09.22 Pennang

  8. Emi Kanemoto, Kazuyuki Kojima, Masatoshi Nakagawa, Mikito Inokuchi, Kenta Kobayashi, Toshiro Tanioka, Kentaro Gokita, Keisuke Okuno, Takatoshi Matsuyama, Yasuaki Nakajima, Yusuke Kinugasa. Implications of less impact of obesity on laparoscopic VS open approach. 91st Annual Meeting of the Japanese Gastric Cancer Association 2019.03.01 Numazu

  9. Mikito Inokuchi、Toshiro Tanioka、Masatoshi Nakagawa、Keisuke Okuno、Kentaro Gokita、Emi kanemoto、Kazuyuki Kojima. Long- and short-term outcomes of laparoscopic gastrectomy in clinical advanced gastric cancer. 第90回日本胃癌学会総会 2018.03.09 横浜

  10. Toshiro Tanioka、Emi kanemoto、Keisuke Okuno、Kentaro Gokita、Masatoshi Nakagawa、Mikito Inokuchi、Kazuyuki Kojima. Intracorporeal esophagojejunostomy using circular stapler after laparoscopic total gastrectomy. 第90回日本胃癌学会総会 2018.03.08 横浜

  11. Masatoshi Nakagawa、Kazuyuki Kojima、Mikito Inokuchi、Toshiro Tanioka、Kentaro Gokita、Keisuke Okuno. Short-term and long-term outcomes after gastrectomy for elderly patients. 第90回日本胃癌学会総会 2018.03.08 横浜

  12. Masatoshi Nakagawa、Emi kanemoto、Kentaro Gokita、Keisuke Okuno、Toshiro Tanioka、Mikito Inokuchi、Kazuyuki Kojima. Double tract reconstruction for laparoscopic proximal gastrectomy in our institute -procedure and short- and middle-term results-. 13th Japan-China-Korea Laparoscopic Gastrectomy Joint Seminar 2018.02.10 別府

  13. Toshiro Tanioka, Keisuke Okuno，Kentaro Gokita，Masatoshi Nakagawa, Mikito Inokuchi, Kazuyuki Kojima. An Intraoperative Educational Annotation System for Endoscopic Surger. 103th Annual Clinical Congress of the American College of Surgeons(ACS2017) 2017.10.25 San Diego

  14. Keisuke Okuno, Kentaro Gokita, Toshiro Tanioka, Norihito Ogawa, Sho Otuki, Mikito Inokuchi, Kazuyuki Kojima. A study on gastroesophageal reflux disease after laparoscopic distal gastrectomy. 12th International Gastric Cancer Congress 2017.04.21

  15. Toshiro Tanioka, Keisuke Okuno, Kentaro Gokita, Mikito Inokuchi, Kazuyuki Kojima. Effect of postoperative complications on the long-term survival of patients with gastric cancer. 12th International Gastric Cancer Congress 2017.04.21

  16. Toshiro Tanioka, Keisuke Okuno, Kentaro Gokita,Norihito Ogawa, Mikito Inokuchi, Kazuyuki Kojima.. Roux-en-Y reconstruction after LDG - surgical technique and functional advantages . China-Japan-Korea Laparoscopic gastrectomy 2017.02.11

  17. Kentaro Gokita, Toshiro Tanioka, Keisuke Okuno, Chiharu Tomii, Hideaki Murase, Sho Otsuki, Mikito Inokuchi, Kazuyuki Kojima, Tatsuyuki Kawano. β-shaped intracorporeal Roux-en-Y Reconstruction after Totally Laparoscopic Distal Gastrectomy. 15th World Congress of Endoscopic Surgery 2016.11.10

  18. Toshiro Tanioka, Keisuke Okuno, Kentaro Gokita, Chiharu Tomii Hideaki Murase, Sho Otsuki, Mikito Inokuchi, Kazuyuki Kojima, Tatsuyuki Kawano. D2 lymph node dissection with splenectomy for laparoscopic total gastrectomy. 15th World Congress of Endoscopic Surgery 2016.11.10

  19. Sho Otsuki, Keisuke Okuno, Kentaro Gokita,, Chiharu Tomii, Toshiro Tanioka, Hideaki Murase, Mikito Inokuchi , Kazuyuki Kojima, Tatsuyuki Kawano. Knack and pitfalls of the No.6 LNs dissection for laparoscopic gastrectomy. 15th World Congress of Endoscopic Surgery 2016.11.10

  20. Keisuke Okuno, Kentaro Gokita, Chiharu Tomii , Toshiro Tanioka, Hideaki Murase, Sho Otsuki, Mikito Inokuchi , Kazuyuki Kojima, Tatsuyuki Kawano. Reconstruction after laparoscopic total gastrectomy by circular stapler using purse-string suturing device (PSD). 15th World Congress of Endoscopic Surgery 2016.11.10

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