Campus Career 【 display / non-display 】
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2015.04-2019.09Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Pulp Biology and Endodontics, Graduate Student
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2020.10-2022.03Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Pulp Biology and Endodontics, Assistant Professor
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2022.04-2022.07Tokyo Medical and Dental University, Tokyo Medical and Dental University, Division of Clinical Dentistry, Department of Conservative Dentistry, Operative Dentistry and Endodontics, Assistant Professor
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2022.08-2023.04Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Oral Health Sciences, Department of Pulp Biology and Endodontics, Visiting Lecturer
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2023.05-2024.04Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Oral Health Sciences, Department of Pulp Biology and Endodontics, Visiting Lecturer
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2024.05-NowTokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Division of Oral Health Sciences, Department of Pulp Biology and Endodontics, Visiting Lecturer
Published Papers & Misc 【 display / non-display 】
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Peifeng Han, Keisuke Sunada-Nara, Nobuyuki Kawashima, Mayuko Fujii, Shihan Wang, Thoai Quoc Kieu, Ziniu Yu, Takashi Okiji. MicroRNA-146b-5p Suppresses Pro-Inflammatory Mediator Synthesis via Targeting TRAF6, IRAK1, and RELA in Lipopolysaccharide-Stimulated Human Dental Pulp Cells. Int J Mol Sci. 2023.04; 24 (8): ( PubMed, DOI )
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Kieu TQ, Tazawa K, Kawashima N, Noda S, Fujii M, Nara K, Hashimoto K, Han P, Okiji T. Kinetics of LYVE-1-positive M2-like macrophages in developing and repairing dental pulp in vivo and their pro-angiogenic activity in vitro. Scientific reports. 2022.03; 12 (1): 5176. ( PubMed, DOI )
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Orikasa S, Kawashima N, Tazawa K, Hashimoto K, Sunada-Nara K, Noda S, Fujii M, Akiyama T, Okiji T. Hypoxia-inducible factor 1α induces osteo/odontoblast differentiation of human dental pulp stem cells via Wnt/β-catenin transcriptional cofactor BCL9 Scientific Reports. 2022.01; 12 (682):
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Sunada-Nara K, Kawashima N, Okiji T. Micro-endodontic management of a fused mandibular molar with rare anatomical features: a case report The International Journal of Microdentistry. 2021.12;
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Kuramoto M, Kawashima N, Tazawa K, Nara K, Fujii M, Noda S, Hashimoto K, Nozaki K, Okiji T. Mineral trioxide aggregate suppresses pro-inflammatory cytokine expression via the calcineurin/nuclear factor of activated T cells/early growth response 2 pathway in lipopolysaccharide-stimulated macrophages. International endodontic journal. 2020.12; 53 (12): 1653-1665. ( PubMed, DOI )
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M Fujii, N Kawashima, K Tazawa, K Hashimoto, K Nara, S Noda, S Nagai, T Okiji. Hypoxia-inducible factor 1α promotes interleukin 1β and tumour necrosis factor α expression in lipopolysaccharide-stimulated human dental pulp cells. Int Endod J. 2020.05; 53 (5): 636-646. ( PubMed, DOI )
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Nara K, Kawashima N, Noda S, Fujii M, Hashimoto K, Tazawa K, Okiji T. Anti-inflammatory roles of microRNA 21 in lipopolysaccharide-stimulated human dental pulp cells. Journal of Cellular Physiology. 2019.11; 234 (11): 21331-21341. ( PubMed, DOI )
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Fujii M, Kawashima N, Tazawa K, Hashimoto K, Nara K, Noda S, Kuramoto M, Orikasa S, Nagai S, Okiji T . HIF1α inhibits LPS-mediated induction of IL-6 synthesis via SOCS3-dependent CEBPβ suppression in human dental pulp cells Biochemical and Biophysical Research Communications . 2019.11; ( DOI )
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Bakhit A, Kawashima N, Hashimoto K, , Noda S, Nara K, , Kuramoto M, Tazawa K, Okiji T. Strontium ranelate promotes odonto-/osteogenic differentiation/mineralization of dental papillae cells in vitro and mineralized tissue formation of the dental pulp in vivo. Scientific Reports. 2018.06; ( PubMed, DOI )
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Hashimoto K, Kawashima N, Ichinose S, Nara K, Sonoko Noda S, Takashi Okiji T. EDTA treatment for NaOCl-treated dentin recovers disturbed attachment and induces differentiation of mouse dental papillae cells Journal of Endodontics. 2017.11;
Conference Activities & Talks 【 display / non-display 】
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Wang S, Sunada-nara K, Kawashima N, Han P, Thoai KW, Yu Z, Okiji T. MicroRNA-27a downregulates proinflammatory cytokines expression in LPS-stimulated human dental pulp cells. 2022 IADR/APR General Session & Exhibition 2022.06.20 VIRTUAL EXPERIENCE
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Han P, Sunada-Nara K, Kawashima N, Wang S, Thoai KQ, Yu Z, Okiji T . MicroRNA-146b suppresses proinflammatory mediators synthesis in lipopolysaccharide-stimulated dental pulp cells. 2022 IADR/APR General Session & Exhibition 2022.06.20 VIRTUAL EXPERIENCE
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Thoai KQ, Tazawa K, Kawashima N, Noda S, Fujii M, Sunada-Nara K, Hashimoto K, Han P & Okiji T. LYVE-1+ M2-macrophages: identification in dental-pulp and their pro-angiogenic activity in-vitro. IADR/APR General Session & Exhibition 2022.06.20 VIRTUAL EXPERIENCE
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Han P, Sunada-Nara K, Kawashima N, Wang S, Thoai KQ, Yu Z, Okiji T . MicroRNA-146b suppresses proinflammatory mediators synthesis in lipopolysaccharide-stimulated dental pulp cells. 2022 IADR/APR General Session & Exhibition 2022.06.20 VIRTUAL EXPERIENCE
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韓沛豊、砂田(奈良)圭介、川島伸之、 Wang S, Thoai KQ, 興地隆史. LPSで刺激されたヒト歯髄細胞におけるMicroRNA146bの抗炎症作用. 日本歯科保存学会2021年度秋季学術大会(155回) 2021.10.28 Web開催
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Fujii M, Kawashima N, Nara K, Noda S, Hashimoto K, Okiji T. Hypoxia-induced microRNA-210 regulates inflammatory cytokine expression in lipopolysaccharide-stimulated dental-pulp cells. 2021 IADR/AADR/CADR General Session 2021.07.22 Virtual Meeting
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Sunada-Nara K, Kawashima N, Fujii M, Noda S, Hashimoto K, Okiji T. MicroRNA -146b downregulates proinflammatory cytokine expression in LPS-stimulated human pulp cells. 2021 IADR/AADR/CADR General Session 2021.07.22 Virtual Meeting
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Tazawa Kento, Kawashima Nobuyuki, Kuramoto Masashi, Nara Keisuke, Fujii Mayuko, Noda Sonoko, Hashimoto Kentaro, Okiji Takashi. TRPA1 is upregulated in response to LPS via p38/MAPK and promotes mineralization in dental pulp cells. 2019年度バランスユニット若手ワークショップ 2020.02.07 Tokyo
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Mayuko F, Nobuyuki K, Shion O, Sonoko N, Keisuke N, Kentaro H, Kento T, Shigenori N, Takashi O. HIF1a inhibits LPS-mediated induction of IL-6 synthesis via SOCS3-dependent CEBPb suppression in human dental pulp cells. The 21th KACD-JSCD Joint Scientific Meeting 2019.11.09 Soul, South korea
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倉本将司,川島伸之,田澤建人,奈良圭介,藤井真由子,野田園子,橋本健太郎,興地隆史. MTAはマクロファージからの炎症性メディエーター産生をcalcineurin/NFATシグナルを介して抑制する. 日本歯科保存学会2019年度秋季学術大会(第151回) 2019.11.08 博多
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Noda S, Kawashima N, Hashimoto K, Nara K, Kuramoto M, Tazawa K, Okiji T. In Vivo Mineralization and In Vitro Differentiation of Dense-Cultured DPSCs. 96th General Session & Exhibition of the IADR 2018.07.25 London, England
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ラネル酸ストロンチウムによるマウス歯乳頭細胞の増殖および石灰化はカルシウム感知受容体を介して誘導される. 第147回日本歯科保存学会2017年度秋季学術大会 2017.10.27 マリオス 盛岡
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倉本将司、川島伸之、野崎浩佑、Bakhit AY、奈良圭介、藤井真由子、橋本健太郎、野田園子、興地隆史. Mineral trioxide aggregateはLPS刺激マクロファージの機能をcalcium-sensing receptor を介して調節する. 第146回日本歯科保存学会2017年春季学術大会 2017.06.08 リンクステーションホール青森、青森
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Nara K, Kawashima N, Noda S, Hashimoto K, Okiji T. MicroRNA21 down-regulates the expression of inflammatory mediators in LPS-stimulated human dental pulp cells via an NF-κB dependent mechanism. The 18th Joint Scientific Meeting of Korean Academy of Conservative Dentistry - Japanese Society of Conservative Dentistry 2016.10.23 Seoul, Korea
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Nara K, Kawashima N, Noda S, Hashimoto K, Bakhit A, Okiji T. Increase of miR21 expression in dental pulp cells and tissues in response to LPS stimulation. IADR Pulp Biology and Regeneration Group Satellite Symposium 2016 2016.06.28 Nagoya
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Hashimoto K, Kawashima N, Nara K, Noda S, Saito M, Okiji T. Recovery effects of EDTA treatment on the attachment and differentiation of mouse dental pulp cells cultured on NaOCl-treated dentin. IADR Pulp Biology and Regeneration Group Satellite Symposium 2016 2016.06.28 Nagoya, Japan
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Bakhit A, Kawashima N, Yamamoto M, Hashimoto K, Noda S, Nara K, Okiji T. Effects of strontium ranelate on the mouse dental papillae cells (MDPs). IADR Pulp Biology and Regeneration Group Satellite Symposium 2016 2016.06.22 Nagoya
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Bakhit A, Kawashima N, Hashimoto K, Noda S, Nara K, Okiji T. Cytotoxic effects of new calcium silicate-based sealers on an osteoblastic cell line. 第142回2015年度日本歯科保存学会秋季学術大会 2015.11.12 文京シビックホール・文京区
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33. Hashimoto K, Kawashima N, Bakhit A, Yamamoto M, Koizumi Y, Takahashi S, Ohi C, Suzuki N. ALPase activity of pulp cells on EDTA and NaClO-treated dentin. 2015 IADR/AADR/CADR General Session 2015.03.11 Hynes Convention Center, Boston, MA
Awards & Honors 【 display / non-display 】
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The Japanese Society of Conservative Dentistry encouragement award,The Japanese Society of Conservative Dentistry,2021.06