Published Papers & Misc - MIYOSHI Masato

1. Taro Shimizu, Masato Miyoshi, Sei Kakinuma, Jun Tsuchiya, Daisuke Yamane, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Kaho Yamada, Kotomi Shinozaki, Ayako Sato, Shun Kaneko, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto. Bile acid-FXR signaling facilitates the long-term maintenance of hepatic characteristics in human iPSC-derived organoids. Cell Rep. 2025.05; 44 (5): 115675. ( PubMed, DOI )

2. Jun Tsuchiya, Masato Miyoshi, Sei Kakinuma, Fukiko Kawai-Kitahata, Akihide Kamiya, Taro Shimizu, Ayako Sato, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Rion Kamimae, Shun Kaneko, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto. Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived Model. Cell Mol Gastroenterol Hepatol. 2025; 19 (2): 101422. ( PubMed, DOI )

3. Murakawa Miyako, Nakagawa Mina, Nishimura Hisaaki, Kaneko Shun, Miyoshi Masato, Kawai-Kitahata Fukiko, Nitta Sayuri, Tsuchiya Jun, Shimizu Taro, Watakabe Keiya, Mochida Tomohiro, Inada Kento, Iizuka Yasuhiro, Sakai Hideki, Sakurai Yuki, Sato Ayako, Azuma Seishin, Kawamura Takahiro, Maeyashiki Chiaki, Kurosaki Masayuki, Kusano Fumihiko, Watanabe Hideki, Kurata Hitoshi, Karakama Yuko, Fujiwara Takeo, Nagata Yuki, Tanaka Toshihiro, Kakinuma Sei, Okamoto Ryuichi, Asahina Yasuhiro. C型肝炎ウイルス排除後の血清γ-グルタミルトランスフェラーゼ高値は肝細胞癌発症の危険因子である(High serum gamma-glutamyltransferase level after hepatitis C virus elimination is a risk factor for the development of hepatocellular carcinoma) Hepatology Research. 2024.12; 54 (12): 1128-1138. ( ichushi )

4. Watakabe K, Miyoshi M, Kakinuma S, Sato A, Tsuchiya J, Shimizu T, Mochida T, Inada K, Kaneko S, Kawai-Kitahata F, Murakawa M, Nitta S, Nakagawa M, Oshima S, Watanabe M, Ma A, Asahina Y, Okamoto R. A20 in hepatic stellate cells suppresses chronic hepatitis by inhibiting DCLK1-JNK pathway-dependent chemokines. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2024.07; 38 (13): e23757. ( PubMed, DOI )

5. Murakawa M, Nakagawa M, Nishimura H, Kaneko S, Miyoshi M, Kawai-Kitahata F, Nitta S, Tsuchiya J, Shimizu T, Watakabe K, Mochida T, Inada K, Iizuka Y, Sakai H, Sakurai Y, Sato A, Azuma S, Kawamura T, Maeyashiki C, Kurosaki M, Kusano F, Watanabe H, Kurata H, Karakama Y, Fujiwara T, Nagata Y, Tanaka T, Kakinuma S, Okamoto R, Asahina Y. High serum gamma-glutamyltransferase level after hepatitis C virus elimination is a risk factor for the development of hepatocellular carcinoma. Hepatology research : the official journal of the Japan Society of Hepatology. 2024.07; 54 (12): 1128-1138. ( PubMed, DOI )

6. Shun Kaneko, Yasuhiro Asahina, Miyako Murakawa, Seishin Azuma, Kento Inada, Tomohiro Mochida, Keiya Watakabe, Taro Shimizu, Jun Tsuchiya, Masato Miyoshi, Fukiko Kawai-Kitahata, Sayuri Nitta, Marie Takahashi, Tomoyuki Fujioka, Mitsuhiro Kishino, Tatsuhiko Anzai, Sei Kakinuma, Mina Nakagawa, Ryuichi Okamoto. Analysis of prognosis and background liver disease in non-advanced hepatocellular carcinoma in two decades. PLoS One. 2024; 19 (3): e0297882. ( PubMed, DOI )

7. Shun Kaneko, Yasuhiro Asahina, Miyako Murakawa, Shunsuke Ueyama, Chiaki Maeyashiki, Hideki Watanabe, Akiko Kusano-Kitazume, Ayako Sato, Kozue Uchidate, Takehito Asakawa, Sho Watanabe, Yasuhiro Iizuka, Isamu Shibata, Shinya Oooka, Yuko Karakama, Takashi Fujii, Taro Watabe, Keiichi Akahoshi, Minoru Tanabe, Kento Inada, Tomohiro Mochida, Keiya Watakabe, Taro Shimizu, Jun Tsuchiya, Masato Miyoshi, Fukiko Kitahata-Kawai, Sayuri Nitta, Mina Nakagawa, Sei Kakinuma, Ryuichi Okamoto, . Prognostic Significance of C-Reactive Protein in Unresectable Hepatocellular Carcinoma treated with Atezolizumab and Bevacizumab. Hepatol Res. 2023.12; Online ahead of print. (6): 562-574. ( PubMed, DOI )

8. Kaneko Shun, Asahina Yasuhiro, Nakagawa Mina, Murakawa Miyako, Miyazaki Yasunari, Asakage Takahiro, Fukuda Shohei, Namiki Takeshi, Kano Yoshihito, Nagata Masashi, Tsuchiya Jun, Miyoshi Masato, Kitahata-Kawai Fukiko, Nitta Sayuri, Itsui Yasuhiro, Kakinuma Sei, Okamoto Ryuichi. 免疫チェックポイント阻害薬による治療が実施された進行癌患者における肝障害および予後関連因子(Factors associated with liver injury and prognosis in advanced cancer patients treated with immune checkpoint inhibitors) Hepatology Research. 2023.05; 53 (5): 450-459. ( ichushi )

9. Shun Kaneko, Yasuhiro Asahina, Mina Nakagawa, Miyako Murakawa, Yasunari Miyazaki, Takahiro Asakage, Shohei Fukuda, Takeshi Namiki, Yoshito Kano, Masashi Nagata, Jun Tsuchiya, Masato Miyoshi, Fukiko Kitahata-Kawai, Sayuri Nitta, Yasuhiro Itsui, Sei Kakinuma, Ryuichi Okamoto. Factors associated with liver injury and prognosis in advanced cancer patients treated with immune checkpoint inhibitors. Hepatol Res. 2023.01; 53 (5): 450-459. ( PubMed, DOI )

10. Nakagawa Mina, Nawa Nobutoshi, Takeichi Eiko, Shimizu Taro, Tsuchiya Jun, Sato Ayako, Miyoshi Masato, Kawai-Kitahata Fukiko, Murakawa Miyako, Nitta Sayuri, Itsui Yasuhiro, Azuma Seishin, Kakinuma Sei, Fujiwara Takeo, Watanabe Mamoru, Tanaka Yujiro, Asahina Yasuhiro. 直接作用型抗ウイルス薬(DAA)によるC型肝炎ウイルス根絶後の患者の生存に関する新規予測バイオマーカーとしてのMac-2結合タンパク糖鎖修飾異性体(Mac-2 binding protein glycosylation isomer as a novel predictive biomarker for patient survival after hepatitis C virus eradication by DAAs) Journal of Gastroenterology. 2020.10; 55 (10): 990-999. ( ichushi )

11. Mina Nakagawa, Nobutoshi Nawa, Eiko Takeichi, Taro Shimizu, Jun Tsuchiya, Ayako Sato, Masato Miyoshi, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Takeo Fujiwara, Mamoru Watanabe, Yujiro Tanaka, Yasuhiro Asahina, . Mac-2 binding protein glycosylation isomer as a novel predictive biomarker for patient survival after hepatitis C virus eradication by DAAs. J. Gastroenterol. 2020.08; 55 (10): 990-999. ( PubMed, DOI )

12. Nitta Sayuri, Takahashi Kazuaki, Kawai-Kitahata Fukiko, Tsuchiya Jun, Sato Ayako, Miyoshi Masato, Murakawa Miyako, Itsui Yasuhiro, Nakagawa Mina, Azuma Seishin, Kakinuma Sei, Watanabe Mamoru, Asahina Yasuhiro. 慢性E型肝炎患者におけるウイルス配列および免疫グロブリン抗体価の経時変化(Time course alterations of virus sequences and immunoglobulin titers in a chronic hepatitis E patient) Hepatology Research. 2020.04; 50 (4): 524-531. ( ichushi )

13. Sayuri Nitta, Kazuaki Takahashi, Fukiko Kawai-Kitahata, Jun Tsuchiya, Ayako Sato, Masato Miyoshi, Miyako Murakawa, Yasuhiro Istui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Mamoru Watanabe, Yasuhiro Asahina. Time course alterations of virus sequences and immunoglobulin titers in a chronic hepatitis E patient Hepatology Research. 2020; 50 (4): 524-531.

14. Kawai-Kitahata Fukiko, Asahina Yasuhiro, Kaneko Shun, Tsuchiya Jun, Sato Ayako, Miyoshi Masato, Tsunoda Tomoyuki, Inoue-Shinomiya Emi, Murakawa Miyako, Nitta Sayuri, Itsui Yasuhiro, Nakagawa Mina, Azuma Seishin, Kakinuma Sei, Tanabe Minoru, Sugawara Emiko, Takemoto Akira, Ojima Hidenori, Sakamoto Michiie, Muraoka Masaru, Takano Shinichi, Maekawa Shinya, Enomoto Nobuyuki, Watanabe Mamoru. 肝細胞癌様領域と異時性肝細胞癌が併存する胆管細胞癌の網羅的遺伝子解析(Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma-like area and metachronous hepatocellular carcinoma) Hepatology Research. 2019.12; 49 (12): 1466-1474. ( ichushi )

15. Fukiko Kawai-Kitahata, Yasuhiro Asahina, Shun Kaneko, Jun Tsuchiya, Ayako Sato, Masato Miyoshi, Tomoyuki Tsunoda, Emi Inoue-Shinomiya, Miyako Murakawa, Sayuri Nitta, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Minoru Tanabe, Emiko Sugawara, Akira Takemoto, Hidenori Ojima, Michiie Sakamoto, Masaru Muraoka, Shinichi Takano, Shinya Maekawa, Nobuyuki Enomoto, Mamoru Watanabe. Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma-like area and metachronous hepatocellular carcinoma. Hepatol. Res.. 2019.07; 49 (12): 1466-1474. ( PubMed, DOI )

16. Emi Inoue-Shinomiya, Miyako Murakawa, Yasuhiro Asahina, Mina Nakagawa, Jun Tsuchiya, Ayako Sato, Tomoyuki Tsunoda, Masato Miyoshi, Sayuri Nitta, Fukiko Kawai-Kitahata, Yasuhiro Itsui, Seishin Azuma, Sei Kakinuma, Kazumoto Murata, Masashi Mizokami, Mamoru Watanabe. Association of serum interferon-λ3 levels with hepatocarcinogenesis in chronic hepatitis C patients treated with direct-acting antiviral agents. Hepatol. Res.. 2019.05; 49 (5): 500-511. ( PubMed, DOI )

17. Inoue-Shinomiya Emi, Murakawa Miyako, Asahina Yasuhiro, Nakagawa Mina, Tsuchiya Jun, Sato Ayako, Tsunoda Tomoyuki, Miyoshi Masato, Nitta Sayuri, Kawai-Kitahata Fukiko, Itsui Yasuhiro, Azuma Seishin, Kakinuma Sei, Murata Kazumoto, Mizokami Masashi, Watanabe Mamoru. 直接作用型抗ウイルス薬を投与されたC型慢性肝炎患者における血清インターフェロン-λ3値と肝細胞癌発症との関連性(Association of serum interferon-λ3 levels with hepatocarcinogenesis in chronic hepatitis C patients treated with direct-acting antiviral agents) Hepatology Research. 2019.05; 49 (5): 500-511. ( ichushi )

18. Sayuri Nitta, Yasuhiro Asahina, Takanobu Kato, Jun Tsuchiya, Emi Inoue-Shinomiya, Ayako Sato, Tomoyuki Tsunoda, Masato Miyoshi, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Sei Kakinuma, Hayato Hikita, Tetsuo Takehara, Mamoru Watanabe. Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients. Sci Rep. 2019.04; 9 (1): 5722. ( PubMed, DOI )

19. Tomoyuki Tsunoda, Sei Kakinuma, Masato Miyoshi, Akihide Kamiya, Shun Kaneko, Ayako Sato, Jun Tsuchiya, Sayuri Nitta, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Tsuyoshi Sogo, Haruki Komatsu, Ryutaro Mukouchi, Ayano Inui, Tomoo Fujisawa, Hiromitsu Nakauchi, Yasuhiro Asahina, Mamoru Watanabe. Loss of fibrocystin promotes interleukin-8-dependent proliferation and CTGF production of biliary epithelium. J. Hepatol.. 2019.03; 71 (1): 143-152. ( PubMed, DOI )

20. Masato Miyoshi, Sei Kakinuma, Akihide Kamiya, Tomoyuki Tsunoda, Jun Tsuchiya, Ayako Sato, Shun Kaneko, Sayuri Nitta, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Hiromitsu Nakauchi, Yasuhiro Asahina, Mamoru Watanabe. LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. Sci Rep. 2019.02; 9 (1): 2072. ( PubMed, DOI )