Conference Activities & Talks -

1. Katarzyna A. Podyma-Inoue, Shiori Tokizaki, Takehisa Matsumoto, Kazuki Takahashi, Miho Kobayashi, Sadahiro Iwabuchi, Hiroyuki Harada, Shinichi Hashimoto, Kohei Miyazono, Mikako Shirouzu and Tetsuro Watabe. Targeting TGF-β with chimeric Fc receptors inhibits crosstalk between various components of tumor microenvironment. 13th AACR-JCA Joint Conference: From Cancer Discovery Science to Therapeutic Innovation 2025.02.02 Maui, Hawaii

2. Kazuki Takahashi, Miho Kobayashi, Hisae Katsumata, Shiori Tokizaki, Tatsuhiko Anzai, Yukinori Ikeda, Daniel M. Alcaide, Yoshiaki Kubota, Fumiko Itoh, Jihwan Park, Kunihiko Takahashi, Yukiko T. Matsunaga, Yasuhiro Yoshimatsu, Katarzyna A. Podyma-Inoue and Tetsuro Watabe. Identification of novel markers in the subsets of endothelial cells undergoing partial endothelial-mesenchymal transition (EndoMT) in tumor microenvironment. 13th AACR-JCA Joint Conference: From Cancer Discovery Science to Therapeutic Innovation 2025.02.02 Maui, Hawaii

3. Haruka Ibi, Katarzyna A. Inoue, Kazuki Takahashi, Takehisa Matsumoto, Mikako Shirouzu, Hiroyuki Harada and Tetsuro Watabe. Transforming growth factor-β signaling facilitates the progression of oral squamous cell carcinoma by triggering epithelial-mesenchymal transition and tumor angiogenesis. 13th AACR-JCA Joint Conference: From Cancer Discovery Science to Therapeutic Innovation 2025.02.02 Maui, Hawaii

4. Kazuki Takahashi,Miho Kobayashi,Hisae Katsumata,Mizuki Tanaka,Yukinori Ikeda,Tatsuhiko Anzai,Katarzyna A. Podyma-Inoue,Jihwan Park,Kunihiko Takahashi,Yasuhiro Yoshimatsu,Yukiko T. Matsunaga,Tetsuro Watabe. がん微小環境においてCD40は部分的な内皮間葉移行を起こした内皮細胞集団において発現している. 第83回日本癌学会学術総会 2024.09.19 福岡市

5. Kazuki Takahashi, Miho Kobayashi, Katarzyna A. Podyma-Inoue, Yusuke Yoshioka, Kashio Fujiwara, Takahiro Ochiya, Tetsuro Watabe. TGF-βによる口腔がん細胞由来の細胞外小胞体の放出は内皮間葉移行を介して血管のバリア機能を低下させる. 第83回日本癌学会学術総会 2024.09.19 福岡市

6. Tetsuro Watabe. Targeting tumor microenvironment networks for developing novel therapeutic strategies.. Asia Pacific Vascular Biology Organization (APVBO) Conference 2024 2024.04.07 広州

7. Takahashi K, Kobayashi M, Katsumata H, Kubota Y, Itoh F, Park J, Podyma-Inoue KA, Watabe T. CD40 is expressed in the subsets of endothelial cells undergoing partial endothelial-mesenchymal transition in tumor microenvironment.. Lymphatics Gordon Research Conference 2024.03.07 Gordon

8. Tetsuro Watabe. TGF-ß Family Members Dysregulate the Homeostasis of Lymphatic Vessels as Negative Lymphoangiocrine Signals,. Lymphatics Gordon Research Conference 2024.03.07

9. Tetsuro Watabe. Targeting tumor microenvironment networks for developing novel therapeutic strategies. FAOPS 2023 (The 10th Federation of the Asian and Oceanian Physiological Societies Congress) 2023.11.01 Daegu

10. Halder Semanti, Yasuyuki Hanada, Yuka Ozeki, Honami Ogo, Yumi Omine, Katarzyna Inoue, Tetsuro Watabe, Akiyoshi Uemura and Koichi Nishiyama. Endothelial cell-pericyte interaction facilitates the establishment of vascular basement membrane with type-4 collagen deposition via Tgfb2-Alk5 in angiogenesis. 第96回日本生化学会大会 2023.11.01 福岡市

11. 井上 カタジナアンナ、高橋 和樹、斎藤 万樹、榊谷 振太郎、飯田 渓太、岩淵 禎弘、鯉沼 代造、小西 徹、田中 晋、戒田 篤志、三浦 雅彦、橋本 真一、岡田 眞里子、内橋 俊大、宮園 浩平、渡部 徹郎. TGF-β は、Slug/HMGA2 非依存性 EMT の誘導を介して、G1 期に停止したがん細胞に高い運動性と転移能を与える. 第82回日本癌学会学術総会 2023.09.23 横浜市

12. Kazuki Takahashi, Miho Kobayashi, Hisae Katsumata, Yukinori Ikeda, Tatsuhiko Anzai, Katarzyna A. Podyma-Inoue, Daniel M Alcaide, Kentaro Maeda, Jihwan Park, Kunihiko Takahashi, Yukiko Matsunaga, Yasuhiro Yoshimatsu, Tetsuro Watabe. Endothelial-mesenchymal transition (EndoMT) reporter cells visualized multiple groups of cells during progression of TGF-β induced EndoMT. Asia-Australia Vascular Biology Meeting 2023 (AAVBM 2023) 2023.09.14 Seoul, Korea

13. Tetsuro Watabe. Characterization of TGF-β-induced partial endothelial-mesenchymal transition (EndoMT) using EndoMT reporter cells.. TGFβ meeting 2023 2023.08.17 Uppsala

14. 小林 美穂, 廣瀬 穂香, 中山 雅敬, 渡部 徹郎. 加齢に伴う血管内皮細胞の減少とストレス応答性の関係. 第30回日本血管生物医学会学術集会（CVMW2022） 2022.12.16

15. 小林 美穂、藤原 花汐、高橋 和樹、吉岡 祐亮、落谷 孝広、渡部 徹郎. 口腔扁平上皮がん細胞由来細胞外小胞による血管不安定化機構. 第87回 口腔病学会学術大会 2022.12.03 東京

16. 小林 美穂, 廣瀬 穂香, 小林 ゆめ, 渡部 徹郎. Vasohibin-1が細胞内輸送に及ぼす影響とその役割. 第45回日本分子生物学会年会 2022.12.01 幕張

17. Tetsuro Watabe. Targeting tumor microenvironment networks for developing novel therapeutic strategies.. KVBM2022 2022.11.25 Korea

18. Tetsuro Watabe. Roles of TGF-β signals during formation and maintenance of vascular systems.. 22nd International Vascular Biology Meeting (IVBM2022) 2022.10.16 Oakland

19. Miho Kobayashi, Honoka Hirose, Masanori Nakayama, Tetsuro Watabe. Relationship between age-dependent vascular endothelial cell decline and stress responsiveness. The 22nd International Vascular Biology Meeting (IVBM2022) 2022.10.14 Oakland, USA

20. 小林 美穂, 藤原 花汐, 鈴木 康弘, 若林 育海, 中山 雅敬, 佐藤 靖史, 渡部 徹郎. 微小管の翻訳後修飾による細胞内輸送調節を介したシグナル伝達制御機構とその役割. 第74回日本細胞生物学会大会 2022.06.30 東京

21. Katarzyna A. Inoue, Kazuki Takahashi, Maki Saito, Shintaro Sakakitani, Toru Konishi, Daizo Koinuma, Akinari Sugauchi, Atsushi Kaida, Yasuhiro Yoshimatsu, Toshihiro Uchihashi, Masahiko Miura, Kohei Miyazono, Tetsuro Watabe. TGF-β-induced cell cycle arrest is correlated with increased migration and metastasis of oral squamous cell carcinoma. 第46回日本リンパ学会総会 2022.06.04 東京都

22. 小林 美穂. 口腔がん細胞が放出するエクソソームによる血管不安定化機構. 第7回 日本血管生物医学会若手研究会 2022.03.05 淡路島（オンライン ハイブリッド）

23. Tetsuro Watabe. Roles of signaling and transcriptional networks during maintenance of vascular systems. 第44回日本分子生物学会 2021.12.02 Yokohama

24. Tetsuro Watabe. Roles of TGF-β family signals during progression of oral cancer.. 13th BMP Conference 2021.11.06 オンライン

25. Yasuhiro Yoshimatsu, Kentaro Maeda, Naoya Takahashi, Ikumi Wakabayashi, Shiori Kimuro, Kazuki Takahashi, Miho Kobayashi, Katarzyna A. Inoue, Masanori Hirashima, Kohei Miyazono, Tetsuro Watabe . Role of an ETS family transcription factor in endothelial mesenchymal transition (EndoMT)-driven EMT. 第80回日本癌学会学術総会 2021.10.01

26. Katarzyna A. Inoue, Kazuki Takahashi, Sakakitani Shintaro, Daizo Koinuma, Akinari Sugauchi, Maki Saito, Atsushi Kaida, Yasuhiro Yoshimatsu, Toshihiro Uchihashi, Masahiko Miura, Kohei Miyazono, Tetsuro Watabe. Activation of epithelial-mesenchymal transition program in oral cancer cells under TGF-β-induced cell cycle arrest. TGF-β Superfamily Conference: Signaling in Development and Disease (FASEB) 2021.07.20

27. Miho Kobayashi、Kashio Fujiwara、Ikumi Wakabayashi、Yasuhiro Suzuki、Masanori Nakayama、Yasufumi Sato、Tetsuro Watabe. Novel anti-angiogenic mechanism of VASH1 through the modification of microtubules. CVMW2020心血管代謝週間（第28回日本血管生物医学会学術集会） 2021.03.12 Web

28. Miho KOBAYASHI, Ikumi Wakabayashi, Yasuhiro Suzuki, Kashio Fujiwara, Masanori Nakayama, Yasufumi Sato, Tetsuro Watabe. Vasohibin-1 induced post-translational modification of microtubules mediates VEGF-signaling in angiogenesis. 第42回日本分子生物学会年会（MBSJ2020） 2020.12.03 WEB

29. Katarzyna A. Inoue, Shintaro Sakakitani, Kazuki Takahashi, Hiroyuki Harada, Tetsuro Watabe. Novel approach for treatment of oral squamous cell carcinoma. 第79回日本癌学会学術総会 2020.10.03 広島

30. Kazuki Takahashi, Katarzyna A. Inoue, Atsushi Kaida, Akinari Sugauchi, Toshihiro Uchihashi, Yasuhiro Yoshimatsu, Susumu Tanaka, Masahiko Miura, Mikihiko Kogo, Tetsuro Watabe. TGF-β-induced cell cycle arrest is associated with increased migration and metastasis of oral squamous carcinoma cells. 第79回日本癌学会学術総会 2020.10 広島

31. Yasuhiro Yoshimatsu, Ikumi Wakabayashi, Shiori Kimuro, Naoya Takahashi, Kazuki Takahashi, Miho Kobayashi, Katarzyna A. Inoue, Kohei Miyazono, Tetsuro Watabe. Endothelial-derived TGF-β signals activated during ednothelial-to-mesenchymal transition induce EMT of oral cancer cells. 第79回日本癌学会学術総会 2020.10

32. Katarzyna A. Inoue, Kazuki Takahashi, Maki Saito, Atsushi Kaida, Akinari Sugauchi, Toshihiro Uchihashi, Yasuhiro Yoshimatsu, Susumu Tanaka, Masahiko Miura, Mikihiko Kogo, Tetsuro Watabe. Oral squamous carcinoma cells under TGF-β-induced cell cycle arrest represent highly motile and invasive population. AACR Virtual Special Conference: Tumor Heterogeneity: From Single Cells to Clinical Impact 2020.09.17

33. Tetsuro Watabe. Roles of TGF-β family signals during formation and maintenance of blood and lymphatic vascular systems.. International Vascular Biology Meeting 2020 2020.09.11 Seoul, Korea

34. Miho Kobayashi,Ikumi Wakabayashi,Yasuhiro Suzuki,Yasufumi Sato,Tetsuro Watabe. Vasohibin-1 Inhibits Angiogenesis via the Increase of Detyrosinated α-Tubulin. The 21st International Vascular Biology Meeting (IVBM2020) 2020.09.09 Korea (WEB hybrid)

35. Katarzyna Inoue, Rina Takayama, Kazuki Takahashi, Tetsuro Watabe. Characterization of exosomes secreted from oral squamous carcinoma cells during epithelial to mesenchymal transition. Proteoglycans 2019 2019.10.01 Kanazawa, Japan

36. Tetsuro Watabe. Roles of TGF-β family signals during the formation and maintenance of vascular systems.. Joint Vascular Biology Meeting 2019.09.20 Sydney,Australia

37. Tetsuro Watabe. TGF-β-induced cell cycle arrest is associated with increased migration and metastasis of oral squamous carcinoma cells.. TGF-β Signaling Meeting 2019.08.24 Leiden,The Netherlands

38. 濵 洋平，水口俊介，佐々木啓一，前田健康，羽村　章，一戸達也，興地隆史，渡部徹郎. 健康長寿を育む歯学教育コンソーシアム -第５報- ５年間を終えて今後の展望. 第38回日本歯科医学教育学会学術大会 2019.07.19 博多

39. Kazuki Takahashi, Katarzyna A. Inoue, Yasuhiro Yoshimatsu, Atsushi Kaida, Kei Takahashi, Shimpei Kubota, Akinari Sugauchi, Toshihiro Uchihashi, Susumu Tanaka, Mikihiko Kogo, Masahiko Miura, Kohei Miyazono and Tetsuro Watabe. . TGF-β-induced cell cycle arrest is associated with increased migration and metastasis of oral squamous carcinoma cells. AACR-JCA Joint Conference 2019.02.09 Maui,Hawaii

40. Tetsuro Watabe. TGF-β family signals in the formation and maintenance of lymphatic systems.. The 41st Annual Meeting of the Molecular Biology Society of Japan 2018.11.28 Yokohama,Japan

41. Tetsuro Watabe. BMP family signals in the formation and maintenance of vascular systems.. 12th International BMP Conference 2018.10.27 Tokyo,Japan

42. Tetsuro Watabe. Roles of TGF-β family signals during the formation and maintenance of vascular systems.. Kitasato Research Forum 2018 2018.07.09 Tokyo

43. Tetsuro Watabe. TGF-β family signals in the formation and maintenance of vascular systems.. International Vascular Biology Meeting 2018 2018.06.03 Helsinki,Finland

44. Tetsuro Watabe. TGF-β signals induce endothelial-to-mesenchymal transition of lymphatic endothelial cells by decreasing PROX1 expression. Lymphatics Gordon Research Conference 2018.03.11 Lucca(Barga)、IT

45. Tetsuro Watabe. Roles of signaling networks during tumor angiogenesis. CardioVascular and Metabolic Week 2017 2017.12.08 Osaka

46. Katarzyna A. Inoue, Kazuki Takahashi, Takumi Matsuda, Yasuhiro Yoshimatsu, Miki Yokoyama and Tetsuro Watabe. Exosomes secreted by oral squamous carcinoma cells undergoing TGF-β-induced epithelial to mesenchymal transition. ConBio2017 2017.12.06 神戸市

47. Tetsuro Watabe, Kazuki Takahashi, Takumi Matsuda, Yasuhiro Yoshimatsu, Atsushi Kaida, Masahiko Miura and Katarzyna A. Inoue. Relationship between cell cycle arrest and epithelial to mesenchymal transition (EMT) induced by TGF-β in oral squamous carcinoma cell. ERATO/AMED-CREST/PRESTO Joint International Symposium 2017.12.04 Kyoto

48. H. Morisaki, I. Yamanaka, T. Ohata, T. Kosho, K. Wakui, Y. Fukushima, M. Masuno, K. Takahashi, T. Watabe, T. Morisaki. TMEPAI mutation causes MFS/LDS-like phenotypes in 2 Japanese families.. The American Society of Human Genetics 2017 2017.10.17 Orlando

49. Tetsuro Watabe. Roles of TGF-βfamily signals during endothelial-to- mesenchymal transition. the TGFbeta meeting in Uppsala 2017 2017.09.02 Sweden

50. Tetsuro Watabe. Targeting signaling networks in tumor microenvironment. 1st International Cancer Precision Medical Conference 2017.06.29 Tokyo

51. Teturo Watabe. Roles of signaling and transcriptional networks in the formation and maintenance of lymphatic vessels. Kitasato Research Forum 2017 on Vascular Biology 2017.05.31 Kitasato University School of Medicine

52. Ershu Ren, Ippei Watari, Hsu Jui-Chin, Mariko Mizumachi-Kubono, Katarzyna Anna Podyma-Inoue, Tetsuro Watabe, Takashi Ono. Unilateral nasal obstruction effects gustatory function in rats. The 39 th Annual Scientific Conference on Dental Research 2017.03.31 Ho Chi Minh city, Vietnam

53. 高橋 和樹、井上 カタジナアンナ、吉松 康裕、原田 浩徳、渡部 徹郎. 口腔がんの悪性化におけるTGF-βシグナルの役割. 第39回日本分子生物学会年会 2016.12 横浜市

54. Tetsuro Watabe. Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis. 11th International BMP Conference 2016.10.28 Boston

55. Katarzyna A. Podyma-Inoue, Miki Yokoyama and Tetsuro Watabe. Characterization of extracellular vesicles isolated from osteoblastic cells lines. 第89回日本生化学会大会 2016.09 仙台市

56. Tetsuro Watabe. Roles of TGF-ß signals in endothelial-to-mesenchymal transition (EndMT) of lymphatic endothelial cells. Gordon Research Conference Lymphatics 2016.03.23 Ventura, USA

57. Tetsuro Watabe, Yuichi Akatsu, Yasuhiro Yoshimatsu, Kohei Miyazono. Dual targeting of vascular endothelial growth factor and bone morphogenetic protein-9/10 impairs tumor growth through inhibition of angiogenesis. 10th AACR-JCA Joint Conference 2016.02.17 Maui, Hawaii, USA

58. Katarzyna A. Podyma-Inoue, Anupama R. Rajapakshe, Takuya Moriwaki, Tetsuro Watabe and Miki Yokoyama. Heparan sulfate proteoglycan and intracellular transport; clues from proteomic analysis of transport vesicles. 第88回日本生化学会大会 2015.12 神戸

59. Tetsuro Watabe. Roles of signaling networks during the formation and maintenance of vascular systems. Asia-Australia Vascular Biology Meeting 2015.10 Busan, Korea

60. Tetsuro Watabe. Roles of signal networks during the formation of vascular systems. KAIST Vascular Biology Meeting 2015.10 Daejeon, Korea

61. Tetsuro Watabe. Roles of Signaling and Transcriptional Networks during Endothelial-to-Mesenchymal Transition. 10th World Congress for Microcirculation 2015.09 Kyoto

62. Roles of signaling networks during endothelial-mesenchymal transition. TGF-β Meeting in Uppsala 2015.08 Uppsala, Sweden