論文・総説 - 水谷　知裕

21. Mizutani T, Clevers H. Primary Intestinal Epithelial Organoid Culture. Methods in molecular biology (Clifton, N.J.). 2020; 2171 185-200. ( PubMed, DOI )

22. Joosten SPJ, Mizutani T, Spaargaren M, Clevers H, Pals ST. MET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug Resistance. Gastroenterology. 2019.10; 157 (4): 1153-1155.e1. ( PubMed, DOI )

23. Sander PJ Joosten, Tomohiro Mizutani, Marcel Spaargaren, Hans Clevers, Steven T Pals. MET signaling overcomes epidermal growth factor receptor inhibition in normal and colorectal cancer stem cells causing drug resistance. Gastroenterology. 2019.06; 157 1153-1155.

24. Fumiaki Ishibashi, Hiromichi Shimizu, Toru Nakata, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Sho Anzai, Reiko Kuno, Sayaka Nagata, Go Ito, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto. Contribution of ATOH1+ Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium. [Epub ahead of print] Stem Cell Reports. 2017.12; 10 (1): 27-42. ( PubMed, DOI )

25. Jarno Drost, Ruben van Boxtel, Francis Blokzijl, Tomohiro Mizutani, Nobuo Sasaki, Valentina Sasselli, Joep de Ligt, Sam Behjati, Judith E Grolleman, Tom van Wezel, Serena Nik-Zainal, Roland P Kuiper, Edwin Cuppen, Hans Clevers. Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer Science. 2017.09; 358 (6360): 234-238. ( PubMed, DOI )

26. Tomohiro Mizutani, Yoshiyuki Tsukamoto, Hans Clevers. Oncogene-inducible organoids as a miniature platform to assess cancer characteristics. J. Cell Biol. 2017.06; 216 (6): 1505-1507. ( PubMed, DOI )

27. Toru Nakata, Hiromichi Shimizu, Sayaka Nagata, Go Ito, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Reiko Kuno, Sho Anzai, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe, Ryuichi Okamoto. Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine. Data Brief. 2017.02; 10 551-556. ( PubMed, DOI )

28. Toru Nakata, Hiromichi Shimizu, Sayaka Nagata, Go Ito, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Reiko Kuno, Sho Anzai, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe, Ryuichi Okamoto. Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors. Biochem. Biophys. Res. Commun. 2017.01; 482 (4): 1296-1303. ( PubMed, DOI )

29. Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Tatsuro Murano, Go Ito, Hiromichi Shimizu, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Akihiro Araki, Kazuo Ohtsuka, Ryuichi Okamoto, Mamoru Watanabe. PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells. Sci Rep. 2016.11; 6 36795. ( PubMed, DOI )

30. Taichi Matsumoto, Wakana Mochizuki, Yoichi Nibe, Shintaro Akiyama, Yuka Matsumoto, Kengo Nozaki, Masayoshi Fukuda, Ayumi Hayashi, Tomohiro Mizutani, Shigeru Oshima, Mamoru Watanabe, Tetsuya Nakamura. Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism. PLoS ONE. 2016.08; 11 (8): e0162049. ( PubMed, DOI )

31. Kengo Nozaki, Wakana Mochizuki, Yuka Matsumoto, Taichi Matsumoto, Masayoshi Fukuda, Tomohiro Mizutani, Mamoru Watanabe, Tetsuya Nakamura. Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes. J. Gastroenterol. 2016.03; 51 (3): 206-213. ( PubMed, DOI )

32. Nobukatsu Horita, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Shuji Hibiya, Masayoshi Fukuda, Yoshihito Kano, Tomohiro Mizutani, Yasuhiro Nemoto, Shiro Yui, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt. Biochem Biophys Res Commun. 2014.10; 454 (4): 493-499. ( PubMed, DOI )

33. Masayoshi Fukuda, Tomohiro Mizutani, Wakana Mochizuki, Taichi Matsumoto, Kengo Nozaki, Yuriko Sakamaki, Shizuko Ichinose, Yukinori Okada, Toshihiro Tanaka, Mamoru Watanabe, Tetsuya Nakamura. Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon. Genes Dev. 2014.08; 28 (16): 1752-1757. ( PubMed, DOI )

34. Hiromichi Shimizu, Ryuichi Okamoto, Go Ito, Satoru Fujii, Toru Nakata, Kohei Suzuki, Tatsuro Murano, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe. Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine. PeerJ. 2014.05; 2 (1): e370. ( PubMed, DOI )

35. Go Ito, Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Tomohiro Mizutani, Shiro Yui, Junko Akiyama-Morio, Yasuhiro Nemoto, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells. PLoS ONE. 2013.11; 8 (11): e79693. ( PubMed, DOI )

36. Tomohiro Mizutani, Tetsuya Nakamura, Ryo Morikawa, Masayoshi Fukuda, Wakana Mochizuki, Yuhki Yamauchi, Kengo Nozaki, Shiro Yui, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Mamoru Watanabe. Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro. Biochem. Biophys. Res. Commun.. 2012.03; 419 (2): 238-243. ( PubMed, DOI )

37. Shiro Yui, Tetsuya Nakamura, Toshiro Sato, Yasuhiro Nemoto, Tomohiro Mizutani, Xiu Zheng, Shizuko Ichinose, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Hans Clevers, Mamoru Watanabe. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nat. Med.. 2012.03; 18 (4): 618-623. ( PubMed, DOI )

38. 岡本 隆一, 水谷 知裕, 藤井 悟, 清水 寛路. 細胞を用いた再生医療の現状と今後の展望 臨床への展開(Vol.13) 炎症性腸疾患と再生医療 医学のあゆみ. 2025.03; 292 (11): 924-928. ( DOI )

39. 岡本 隆一, 水谷 知裕, 藤井 悟, 清水 寛路. 細胞を用いた再生医療の現状と今後の展望　臨床への展開(Vol.13)　炎症性腸疾患と再生医療 医学のあゆみ. 2025.03; 292 (11): 924-928. ( 医中誌 )

40. 水谷 知裕. 特集：炎症性腸疾患_病態における腸上皮の役割 Medical Practice. 2024.11; 41 (11): 1662-1666.