Personnel Information

写真a

Tetuya Nagata


Job title

Professor

Birth date

1968

Mail Address

t-naga.nuro@tmd.ac.jp

Graduating School 【 display / non-display

  • Tohoku University, Faculty of Medicine, 1994.03, Graduated

Graduate School 【 display / non-display

  • Tohoku University, Graduate School, Division of Medical Sciences, Doctor's Course, 1999.03, Completed

Campus Career 【 display / non-display

  • 2014.11
    -
    2016.05
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Project Junior Associate Professor
  • 2016.06
    -
    2017.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Junior Associate Professor
  • 2017.04
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Junior Associate Professor
  • 2018.04
    -
    2019.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Associate Professor
  • 2019.04
    -
    2019.10
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Project Associate Professor
  • 2019.11
    -
    2022.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Associate Professor
  • 2022.04
    -
    2022.07
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Cognitive and Behavioral Medicine, Neurology and Neurological Science, Project Associate Professor
  • 2022.08
    -
    Now
    Tokyo Medical and Dental University, Institute of Research, a, TIDE Center, Professor

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External Career 【 display / non-display

  • 2003
    -
    2005
    Okayama University, Department of Neurology, Assistant Professor
  • 2005
    -
    2008
    Columbia University, Postdoctoral fellow
  • 2008
    -
    2009
    Okayama University, Department of Neurology, Assistant Professor
  • 2009
    -
    2014.10
    National Center of Neurology and Psychiatry, National Institute of Neuroscience, Director

Research Areas 【 display / non-display

  • Neurology

Qualification Acquired 【 display / non-display

  • Doctor

 

Published Papers & Misc 【 display / non-display

  1. Motohiro Suzuki, Satoru Ishibashi, Eri Iwasawa , Takahiro Oguma, Yasuhiro Saito, Fuying Li, Shinichi Otsu, Keiko Ichinose, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota. Effective silencing of miR-126 after ischemic stroke by means of intravenous α-tocopherol-conjugated heteroduplex oligonucleotide in mice. Scientific reports. 2021.07; 11 (1): 14237. ( PubMed, DOI )

  2. Yuki Kishimoto, Osamu Nakagawa, Akane Fujii, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota, Yoshiyuki Hari, Satoshi Obika. 2',4'-BNA/LNA with 9-(2-Aminoethoxy)-1,3-diaza-2-oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance*. Chemistry (Weinheim an der Bergstrasse, Germany). 2021.02; 27 (7): 2427-2438. ( PubMed, DOI )

  3. Yutaro Asami, Tetsuya Nagata, Kotaro Yoshioka, Taiki Kunieda, Kie Yoshida-Tanaka, C Frank Bennett, Punit P Seth, Takanori Yokota. Efficient Gene Suppression by DNA/DNA Double-Stranded Oligonucleotide In Vivo. Molecular therapy : the journal of the American Society of Gene Therapy. 2021.02; 29 (2): 838-847. ( PubMed, DOI )

  4. Nagata Tetsuya. BBB透過性ヘテロ二重鎖オリゴヌクレオチド(BBB-penetrating heteroduplex oligonucleotide) 臨床神経学. 2020.11; 60 (Suppl.): S255. ( ichushi )

  5. Ohyagi Masaki, Nagata Tetsuya, Ihara Kensuke, Nishi Rieko, Mabuchi Yo, Akazawa Chihiro, Yokota Takanori. DNA/RNAヘテロ二重鎖オリゴヌクレオチド技術を用いた多発性硬化症に対する新規治療戦略(New therapeutic strategy for multiple sclerosis by DNA/RNA heteroduplex oligonucleotide technology) 臨床神経学. 2020.11; 60 (Suppl.): S293. ( ichushi )

  6. Jia Chunyan, Yoshioka Kotaro, Mon Su Su Lei, Tanaka Kie, Nagata Tetsuya, Yokota Takanori. CNS疾患に対するヘテロ二重鎖オリゴヌクレオチド使用による治療指標の改善(Hetereoduplex oligonucleotides technology improves therapeutic index for CNS diseases) 臨床神経学. 2020.11; 60 (Suppl.): S323. ( ichushi )

  7. Yokota Takanori, Nagata Tetsuya, Dwyer Chrissa, Yoshida Kie, Yoshioka Kotaro, Seth Punit, Rigo Frank, Bennett Frank. BBB透過性ヘテロ二重鎖オリゴヌクレオチド(HDO)の開発(Development of BBB-penetrating heteroduplex oligonucleotides(HDO)) 臨床神経学. 2020.11; 60 (Suppl.): S314. ( ichushi )

  8. Yokoyama H, Hirai T, Nagata T, Enomoto M, Kaburagi H, Leiyo L, Motoyoshi T, Yoshii T, Okawa A, Yokota T. DNA Microarray Analysis of Differential Gene Expression in the Dorsal Root Ganglia of Four Different Neuropathic Pain Mouse Models. Journal of pain research. 2020; 13 3031-3043. ( PubMed, DOI )

  9. Yoshioka Kotaro, Su Su Lei Mon , Jia Chunyan, Yamada Hiroki, Asami Yutaro, Tanaka Kie, Wenying Piao, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. CNSを標的としたオーバーハングヘテロ二2本鎖核酸を用いた新しいアンチセンスオリゴヌクレオチド治療(A novel antisense oligonucleotide therapy by overhanging heteroduplex oligonucleotide targeting CNS) 臨床神経学. 2019.11; 59 (Suppl.): S408. ( ichushi )

  10. Uehara T, Choong CJ, Nakamori M, Hayakawa H, Nishiyama K, Kasahara Y, Baba K, Nagata T, Yokota T, Tsuda H, Obika S, Mochizuki H. Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting α-synuclein as a novel therapy for Parkinson's disease. Scientific reports. 2019.05; 9 (1): 7567. ( PubMed, DOI )

  11. Yoshiaki Masaki, Keishi Yamamoto, Takeshi Inde, Keita Yoshida, Atsuya Maruyama, Tetsuya Nagata, Jun Tanihata, Shin'ichi Takeda, Mitsuo Sekine, Kohji Seio. Synthesis of 2'-O-(N-methylcarbamoylethyl) 5-methyl-2-thiouridine and its application to splice-switching oligonucleotides. Bioorg. Med. Chem. Lett.. 2018.12; ( PubMed, DOI )

  12. Nagata Tetsuya. DNA/RNAヘテロ2本鎖核酸の最近の進歩(Recent progress of DNA/RNA heteroduplex oligonucleotide) 臨床神経学. 2018.12; 58 (Suppl.): S47. ( ichushi )

  13. Kenji Rowel Q Lim*, Yusuke Echigoya*, Tetsuya Nagata*, Mutsuki Kuraoka, Masanori Kobayashi, Yoshitsugu Aoki, Terence Partridge, Rika Maruyama, Shin'ichi Takeda, Toshifumi Yokota *Equal Contribution . Efficacy of Multi-exon Skipping Treatment in Duchenne Muscular Dystrophy Dog Model Neonates. Mol. Ther.. 2018.10; ( PubMed, DOI )

  14. Naoki Watanabe*, Tetsuya Nagata*, Youhei Satou, Satoru Masuda, Takashi Saito, Hidetoshi Kitagawa, Hirofumi Komaki, Kazuchika Takagaki, Shin'ichi Takeda *Equal Contribution. NS-065/NCNP-01: An Antisense Oligonucleotide for Potential Treatment of Exon 53 Skipping in Duchenne Muscular Dystrophy. Mol Ther Nucleic Acids. 2018.09; 13 442-449. ( PubMed, DOI )

  15. Uehara T., Choong C. J., Hayakawa H., Kasahara Y., Nagata T., Yokota T., Baba K., Nakamori M., Obika S., Mochizuki H.. Antisense oligonucleotides containing amido-bridged nucleic acid reduce SNCA expression and improve motor function in Parkinson's disease animal models JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 1044-1045. ( DOI )

  16. Yoshioka K., Kunieda T., Asami Y., Sujino Y., Tanaka K., Piao W., Kuwahara H., Nishina K., Nagata T., Yokota T.. Dual overhanging-duplex oligonucleotide improved efficacy and safety in gene therapy for FAP JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 140. ( DOI )

  17. Hitoshi Suzuki, Yoshitsugu Aoki, Toshiki Kameyama, Takashi Saito, Satoru Masuda, Jun Tanihata, Tetsuya Nagata, Akila Mayeda, Shin'ichi Takeda, Toshifumi Tsukahara. Endogenous Multiple Exon Skipping and Back-Splicing at the DMD Mutation Hotspot. Int J Mol Sci. 2016.10; 17 (10): ( PubMed, DOI )

  18. Mutsuki Kuraoka, En Kimura, Tetsuya Nagata, Takashi Okada, Yoshitsugu Aoki, Hisateru Tachimori, Naohiro Yonemoto, Michihiro Imamura, Shin'ichi Takeda. Serum Osteopontin as a Novel Biomarker for Muscle Regeneration in Duchenne Muscular Dystrophy. Am. J. Pathol.. 2016.05; 186 (5): 1302-1312. ( PubMed, DOI )

  19. Koichi Kimura, Hiroyuki Morita, Masao Daimon, Masaru Horio, Takayuki Kawata, Tomoko Nakao, Megumi Hirokawa, Ruriko Kitao, Daisuke Watanabe, Tetsuo Komori, Tetsuya Nagata, Shin'ichi Takeda, Hirofumi Komaki, Kazuhiko Segawa, Takashi Nakajima, Katsu Takenaka, Issei Komuro. Utility of Cystatin C for Estimating Glomerular Filtration Rate in Patients With Muscular Dystrophy. Int Heart J. 2016.05; 57 (3): 386-388. ( PubMed, DOI )

  20. Masaki Y, Inde T, Nagata T, Tanihata J, Kanamori T, Seio K, Takeda S, Sekine M. Enhancement of exon skipping in mdx52 mice by 2'-O-methyl-2-thioribothymidine incorporation into phosphorothioate oligonucleotides Med Chem Commun. 2015.04; 6 630-633. ( DOI )

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Conference Activities & Talks 【 display / non-display

  1. Tetsuya Nagata. BBB-penetrating heteroduplex oligonucleotide. 61st Annual Meeting of the Japanese Society of Neurology 2020.09.02 Okayama

Patents 【 display / non-display

  • α-SYNUCLEIN EXPRESSION INHIBITOR

    Patent Number: US11234995

Others 【 display / non-display

  • How a two-faced molecule can silence problematic genes,2022.02

    AAAS EurekAlert! The Global Source for Science News

  • From blood to brain: Delivering nucleic acid therapy to the CNS,2021.08

    AAAS EurekAlert! The Global Source for Science News