Personnel Information

写真a

NODA Sonoko


Job title

Visiting Lecturer
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Dentistry, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Doctor's Course, Completed

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Campus Career 【 display / non-display 】

  • 2015.04
    -
    2019.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Oral Health Sciences， Pulp Biology and Endodontics， Graduate Student
  • 2021.04
    -
    2021.09
    Tokyo Medical and Dental University， (Old Organization)Dental Hospital， Hospital Departments， Clinics for Conservation of Oral and Maxillofacial Function， Operative Dentistry and Endodontics， Project Assistant Professor
  • 2021.10
    -
    2023.03
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Dentistry， Department of Conservative Dentistry， Operative Dentistry and Endodontics， Project Assistant Professor
  • 2023.05
    -
    2024.04
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Oral Health Sciences， Department of Pulp Biology and Endodontics， Visiting Lecturer
  • 2024.05
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Oral Health Sciences， Department of Pulp Biology and Endodontics， Visiting Lecturer
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Published Papers & Misc 【 display / non-display 】

  1. Noda s, Kawashima N, Yamamoto M, Hashimoto K, Nara N, Sekiya I, Okiji T. Effect of cell culture density on dental pulp-derived mesenchymal stem cells with reference to osteogenic differentiation Scientific Reports. 2019.04; 9 (1): 5430. ( DOI )

  2. Nyein Chan KO, Sonoko NODA, Yamato OKADA, Kento TAZAWA, Nobuyuki KAWASHIMA and Takashi OKIJI. Biocompatibility and pro-mineralization effects of premixed calcium silicatebased materials on human dental pulp stem cells: An in vitro and in vivo study Dental Materials Journal. 2024.09; 43 (5): 729-737.

  3. Alchawoosh A, Hashimoto K, Kawashima N, Noda S, Nozaki K, Okiji T. Hydraulic calcium silicate-based root canal sealers mitigate proinflammatory cytokine synthesis and promote osteogenesis in vitro Journal of Dental Sciences. 2023; ( DOI )

  4. Kieu TQ, Tazawa K, Kawashima N, Noda S, Fujii M, Nara K, Hashimoto K, Han P, Okiji T. Kinetics of LYVE-1-positive M2-like macrophages in developing and repairing dental pulp in vivo and their pro-angiogenic activity in vitro. Scientific reports. 2022.03; 12 (1): 5176. ( PubMed, DOI )

  5. Orikasa S, Kawashima N, Tazawa K, Hashimoto K, Sunada-Nara K, Noda S, Fujii M, Akiyama T, Okiji T. Hypoxia-inducible factor 1α induces osteo/odontoblast differentiation of human dental pulp stem cells via Wnt/β-catenin transcriptional cofactor BCL9 Scientific Reports. 2022.01; 12 (682):

  6. Okada Y, Kawashima N, Nod S, Murano H, Han P, Hashimoto K, Kaneko T, Okiji T. VEGFA promotes odonto/osteoblastic differentiation in dental pulp stem cells via ERK/p38 signaling Journal of Dental Sciences. 2022; in press ( DOI )

  7. Thein HSS, Hashimoto K, Kawashima N, Noda S, Okiji T . Evaluation of the anti-inflammatory effects of surface-reaction-type pre-reacted glass-ionomer filler containing root canal sealer in lipopolysaccharide-stimulated RAW264.7 macrophages Dental Materials Journal. 2021;

  8. Kuramoto M, Kawashima N, Tazawa K, Nara K, Fujii M, Noda S, Hashimoto K, Nozaki K, Okiji T. Mineral trioxide aggregate suppresses pro-inflammatory cytokine expression via the calcineurin/nuclear factor of activated T cells/early growth response 2 pathway in lipopolysaccharide-stimulated macrophages. International endodontic journal. 2020.12; 53 (12): 1653-1665. ( PubMed, DOI )

  9. Fujii M, Kawashima N, Tazawa K, Hashimoto K, Nara K, Noda S, Nagai S, Okiji T.. Hypoxia-inducible factor 1α promotes interleukin 1β and tumour necrosis factor α expression in lipopolysaccharide-stimulated human dental pulp cells. International Endodontic Journal. 2020.01; ( DOI )

  10. Tazawa K, Kawashima N, Kuramoto M, Noda S, Fujii M, Nara K, Hashimoto K, Okiji T. Transient Receptor Potential Ankyrin 1 (TRPA1) is Up-Regulated in Response to Lipopolysaccharide via P38/ Mitogen-Activated Protein Kinase (MAPK) in Dental Pulp Cells and Promotes Mineralization. The American Journal of Pathology. 2020;

  11. Nara K, Kawashima N, Noda S, Fujii M, Hashimoto K, Tazawa K, Okiji T. Anti-inflammatory roles of microRNA 21 in lipopolysaccharide-stimulated human dental pulp cells. Journal of Cellular Physiology.. 2019.11; 234 (11): 21331-21341. ( PubMed, DOI )

  12. Fujii M, Kawashima N, Tazawa K, Hashimoto K, Nara K, Noda S, Kuramoto M, Orikasa S, Nagai S, Okiji T . HIF1α inhibits LPS-mediated induction of IL-6 synthesis via SOCS3-dependent CEBPβ suppression in human dental pulp cells Biochemical and Biophysical Research Communications . 2019.11; ( DOI )

  13. Bakhit A, Kawashima N, Hashimoto K, , Noda S, Nara K, , Kuramoto M, Tazawa K, Okiji T. Strontium ranelate promotes odonto-/osteogenic differentiation/mineralization of dental papillae cells in vitro and mineralized tissue formation of the dental pulp in vivo. Scientific Reports. 2018.06; ( PubMed, DOI )

  14. Hashimoto K, Kawashima N, Ichinose S, Nara K, Sonoko Noda S, Takashi Okiji T. EDTA treatment for NaOCl-treated dentin recovers disturbed attachment and induces differentiation of mouse dental papillae cells Journal of Endodontics. 2017.11;

  15. Kawashima N, Noda S, Yamamoto M, Okiji T. Properties of dental pulp-derived mesenchymal stem cells and the effects of culture conditions Journal of Endodontics. 2017;

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Conference Activities & Talks 【 display / non-display 】

  1. ラット臼歯歯髄へのMO貼付に伴う視床におけるSostdc1 mRNA発現の低下. 日本歯科保存学会2023年度秋季学術大会（第159回） 2023.11.11 浜松

  2. Han P, Sunada-Nara K, Kawashima N, Wang S, Thoai KQ, Yu Z, Okiji T . MicroRNA-146b suppresses proinflammatory mediators synthesis in lipopolysaccharide-stimulated dental pulp cells. 2022 IADR/APR General Session & Exhibition 2022.06.20 VIRTUAL EXPERIENCE

  3. Thoai　KQ, Tazawa K, Kawashima N, Noda S, Fujii M, Sunada-Nara K, Hashimoto K, Han P & Okiji T. LYVE-1+ M2-macrophages: identification in dental-pulp and their pro-angiogenic activity in-vitro. IADR/APR General Session & Exhibition 2022.06.20 VIRTUAL EXPERIENCE

  4. Okada Y, Kawashima N, Noda S, Murano H, Zaw ZCT, Han P, Hashimoto K, Okiji T. Vascular endothelial growth factor promotes migration and osteo/odontoblastic differentiation of SHEDs via ERK signaling. The International Scientific Meeting of 30th Anniversary of Korean Academy of Endodontics & the 19th JEA-KAE Joint Scientific Meeting 2021.10.29 Seoul, Korea

  5. Sunada-Nara K, Kawashima N, Fujii M, Noda S, Hashimoto K, Okiji T. MicroRNA -146b downregulates proinflammatory cytokine expression in LPS-stimulated human pulp cells.. 2021 IADR/AADR/CADR General Session 2021.07.22 Virtual Meeting

  6. Fujii M, Kawashima N, Nara K, Noda S, Hashimoto K, Okiji T.. Hypoxia-induced microRNA-210 regulates inflammatory cytokine expression in lipopolysaccharide-stimulated dental-pulp cells. 2021 IADR/AADR/CADR General Session 2021.07.22 Virtual Meeting

  7. Kieu Quoc T, Tazawa K, Kawashima N, Nara K, Fujii M, Noda S, Hashimoto K, Okiji T. Lyve-1+ Pulpal Macrophages: M2-polarization and Response to Cavity Preparation. The 68th Annual Meeting of Japanese Assosiation for Dental Research 2020.11.07 Vertual Meeting

  8. Tazawa Kento, Kawashima Nobuyuki, Kuramoto Masashi, Nara Keisuke, Fujii Mayuko, Noda Sonoko, Hashimoto Kentaro, Okiji Takashi. TRPA1 is upregulated in response to LPS via p38/MAPK and promotes mineralization in dental pulp cells. 2019年度バランスユニット若手ワークショップ 2020.02.07 Tokyo

  9. Mayuko F, Nobuyuki K, Shion O, Sonoko N, Keisuke N, Kentaro H, Kento T, Shigenori N, Takashi O. HIF1a inhibits LPS-mediated induction of IL-6 synthesis via SOCS3-dependent CEBPb suppression in human dental pulp cells. The 21th KACD-JSCD Joint Scientific Meeting 2019.11.09 Soul, South korea

  10. 倉本将司，川島伸之，田澤建人，奈良圭介，藤井真由子，野田園子，橋本健太郎，興地隆史. MTAはマクロファージからの炎症性メディエーター産生をcalcineurin/NFATシグナルを介して抑制する. 日本歯科保存学会２０１９年度秋季学術大会（第１５１回） 2019.11.08 博多

  11. Noda S, Kawashima N, Hashimoto K, Nara K, Kuramoto M, Tazawa K, Okiji T. In Vivo Mineralization and In Vitro Differentiation of Dense-Cultured DPSCs. 96th General Session & Exhibition of the IADR 2018.07.25 London, England

  12. Kawashima N, Noda S, Yamamoto M, Okiji T. Hard-tissue forming properties of dental pulp derived-mesenchymal stem cells. 2017 Faculty Annual Scientific Meeting of Hong Kong University 2017.12.14 Prince Philip Dental Hospital, Hong Kong University, Hong Kong

  13. ラネル酸ストロンチウムによるマウス歯乳頭細胞の増殖および石灰化はカルシウム感知受容体を介して誘導される. 第147回日本歯科保存学会2017年度秋季学術大会 2017.10.27 マリオス　盛岡

  14. 倉本将司、川島伸之、野崎浩佑、Bakhit AY、奈良圭介、藤井真由子、橋本健太郎、野田園子、興地隆史. Mineral trioxide aggregateはLPS刺激マクロファージの機能をcalcium-sensing receptor を介して調節する. 第146回日本歯科保存学会2017年春季学術大会 2017.06.08 リンクステーションホール青森、青森

  15. Noda S, Kawashima N, Hashimoto K, Aramaki O, Yamamoto M, Okiji T. Dense culture conditions induced human dental pulp stem cell differentiation. 95th Generel Session & Exhibition of the IADR 2017.03.22 San Francisco, CA

  16. Kawashima N, Noda S, Hashimoto K, Saito M, Okiji T. Meis2 induces odonto-/osteoblastic differentiation and mineralization . 95th General Session & Exhibition of the IADR 2017.03.22 San Francisco, CA

  17. Nara K, Kawashima N, Noda S, Hashimoto K, Okiji T. MicroRNA21 down-regulates the expression of inflammatory mediators in LPS-stimulated human dental pulp cells via an NF-κB dependent mechanism. 2016 Autumn Scientific Meeting (the 146th) and Joint Scientific Meeting of KACD-JACD (the 18th) 2016.10.23 Seoul, Korea

  18. Nara K, Kawashima N, Noda S, Hashimoto K, Bakhit A, Okiji T. Increase of miR21 expression in dental pulp cells and tissues in response to LPS stimulation. IADR Pulp Biology and Regeneration Group Satellite Symposium 2016 2016.06.28 Nagoya, Japan

  19. Noda S, Kawashima N, Hashimoto K, Aramaki O, Yamamoto M, Okiji T. Effects of confluent culture condition on dental pulp stem cell surface markers, proliferation, gene expression. IADR Pulp Biology and Regeneration Group Satellite Symposium 2016 2016.06.28 Nagoya

  20. Hashimoto K, Kawashima N, Nara K, Noda S, Saito M, Okiji T. Recovery effects of EDTA treatment on the attachment and differentiation of mouse dental pulp cells cultured on NaOCl-treated dentin. IADR Pulp Biology and Regeneration Group Satellite Symposium 2016 2016.06.28 Nagoya, Japan

  21. Kawashima N, Noda S, Hashimoto K, Yamamoto M, Okiji T. Properties of dental pulp derived-mesenchymal stem cells and effects of culture conditions . IADR Pulp Biology and Regeneration Group Satellite Symposium 2016 2016.06.26

  22. Bakhit A, Kawashima N, Yamamoto M, Hashimoto K, Noda S, Nara K, Okiji T. Effects of strontium ranelate on the mouse dental papillae cells (MDPs). IADR Pulp Biology and Regeneration Group Satellite Symposium 2016 2016.06.22 Nagoya

  23. Bakhit A, Kawashima N, Hashimoto K, Noda S, Nara K, Okiji T. Cytotoxic effects of new calcium silicate-based sealers on an osteoblastic cell line. 第142回2015年度日本歯科保存学会秋季学術大会 2015.11.12 文京シビックホール・文京区

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