論文・総説 - 今井　穣

1. Minoru Imai, Tatsuki Shiota, Ken-ichiro Kataoka, Christine M Tarby, Wilna J Moree, Takaharu Tsutsumi, Masaki Sudo, Michele M Ramirez-Weinhouse, Daniel Comer, Chung-Ming Sun, Shinsuke Yamagami, Hiroko Tanaka, Takuya Morita, Takahiko Hada, Jonathan Greene, Doug Barnum, John Saunders, Peter L Myers, Yoshinori Kato, Noriaki Endo. Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives. Bioorganic & Medicinal Chemistry Letters. 2004.11; 14 (21): 5407-5411. ( PubMed, DOI )

2. Wilna J Moree, Ken-ichiro Kataoka, Michele M Ramirez-Weinhouse, Tatsuki Shiota, Minoru Imai, Masaki Sudo, Takaharu Tsutsumi, Noriaki Endo, Yumiko Muroga, Takahiko Hada, Hiroko Tanaka, Takuya Morita, Jonathan Greene, Doug Barnum, John Saunders, Yoshinori Kato, Peter L Myers, Christine M Tarby. Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives. Bioorganic & Medicinal Chemistry Letters. 2004.11; 14 (21): 5413-5416. ( PubMed, DOI )

3. Wilna J Moree, Ken-ichiro Kataoka, Michele M Ramirez-Weinhouse, Tatsuki Shiota, Minoru Imai, Takaharu Tsutsumi, Masaki Sudo, Noriaki Endo, Yumiko Muroga, Takahiko Hada, Dewey Fanning, John Saunders, Yoshinori Kato, Peter L Myers, Christine M Tarby. Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series. Bioorganic & Medicinal Chemistry Letters. 2008.03; 18 (6): 1869-1873. ( PubMed, DOI )

4. Tomomi Kosugi, Dale R Mitchell, Aiko Fujino, Minoru Imai, Mika Kambe, Shinji Kobayashi, Hiroaki Makino, Yohei Matsueda, Yasuhiro Oue, Kanji Komatsu, Keiichiro Imaizumi, Yuri Sakai, Satoshi Sugiura, Osami Takenouchi, Gen Unoki, Yuko Yamakoshi, Vicky Cunliffe, Julie Frearson, Richard Gordon, C John Harris, Heidi Kalloo-Hosein, Joelle Le, Gita Patel, Donald J Simpson, Brad Sherborne, Peter S Thomas, Naotaka Suzuki, Midori Takimoto-Kamimura, Ken-ichiro Kataoka. Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach. Journal of Medicinal Chemistry. 2012.08; 55 (15): 6700-6715. ( PubMed, DOI )

5. Takagi Masatoshi, Ogawa Chitose, Aoki-Nogami Yuki, Iehara Tomoko, Ishibashi Eri, Imai Minoru, Kihara Tetsuro, Nobori Kiyoshi, Hasebe Kazuhisa, Mizutani Shuki, Kimura Toshimi, Nagata Masashi, Yasuhara Masato, Yoshimura Kenichi, Yorozu Pariko, Hosoi Hajime, Koike Ryuji. Phase I clinical study of oral olaparib in pediatric patients with refractory solid tumors: study protocol BMC PEDIATRICS. 2019.01; 19 (1): 31. ( PubMed, DOI )

6. Takagi M, Ogawa C, Iehara T, Aoki-Nogami Y, Ishibashi E, Imai M, Kimura T, Nagata M, Yasuhara M, Masutani M, Yoshimura K, Tomizawa D, Ogawa A, Yonemori K, Morishita A, Miyamoto S, Takita J, Kihara T, Nobori K, Hasebe K, Miya F, Ikeda S, Shioda Y, Matsumoto K, Fujimura J, Mizutani S, Morio T, Hosoi H, Koike R. First phase 1 clinical study of olaparib in pediatric patients with refractory solid tumors. Cancer. 2022.05; 128 (15): 2949-2957. ( PubMed, DOI )

7. 今井穣, 影近弘之. 核内レチノイド受容体を標的とした新規制癌剤の創製 医学のあゆみ. 2014.06; 249 (11): 1189-1193.

8. 小池 竜司, 今井 穣, 石見 香, 新井 文子. 希少難治疾患の医師主導治験の問題点　慢性活動性Epstein-Barrウイルス感染症対象の治験の立案から開始まで 臨床薬理. 2019.11; 50 (Suppl.): S261. ( 医中誌 )

9. Mori Masaaki, Yoshizaki Kanako, Watabe Shinichi, Ishige Mika, Hinoki Akinari, Kondo Takuya, Taguchi Tomoaki, Hasegawa Hisaya, Hatata Tomoko, Tanuma Naoyuki, Kirino Kosuke, Hirakawa Akihiro, Naruto Takuya, Imai Minoru, Koike Ryuji, Hosoi Kenichiro, Kusuda Satoshi. Safety, efficacy and pharmacokinetics of palivizumab in off- label neonates, infants, and young children at risk for serious respiratory syncytial virus infection: a multicenter phase II clinical trial LANCET REGIONAL HEALTH-WESTERN PACIFIC. 2023.10; 39 100847. ( PubMed, DOI )