Personnel Information

写真a

NAGATA Mizuki


Job title

Assistant Professor
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Dentistry, 2012.03, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Doctor's Course, 2017.03, Completed

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Campus Career 【 display / non-display 】

  • 2013.04
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    2017.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Periodontology， Graduate Student
  • 2022.05
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    2023.04
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Bio-Matrix， Department of Periodontology， Visiting Lecturer
  • 2023.05
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    2024.04
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Bio-Matrix， Department of Periodontology， Visiting Lecturer
  • 2024.05
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    2024.06
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Bio-Matrix， Department of Periodontology， Visiting Lecturer
  • 2024.07
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    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Bio-Matrix， Periodontology， Assistant Professor
  • 2024.10
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    2025.01
    Institute of Science Tokyo， -， Graduate Schools， Bio-Matrix， Department of Periodontology， Assistant Professor
  • 2025.02
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    Now
    Institute of Science Tokyo， -， Institute of Science Tokyo Hospital， Department of Conservative Dentistry， Periodontics， Assistant Professor

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Published Papers & Misc 【 display / non-display 】

  1. Nagata M, Gadhvi GT, Komori T, Arai Y, Manabe H, Chu AKY, Kaur R, Ali M, Yang Y, Tsutsumi-Arai C, Nakai Y, Matsushita Y, Tokavanich N, Zheng WJ, Welch JD, Ono N, Ono W. Wnt-directed CXCL12-expressing apical papilla progenitor cells drive tooth root formation. Nat Commun. 2025.07; 16 (1): 5510. ( PubMed, DOI )

  2. Nagata M, Gadhvi GT, Komori T, Arai Y, Tsutsumi-Arai C, Chu AKY, Nye SN, Yang Y, Orikasa S, Takahashi A, Carlsson P, Zheng WJ, Welch JD, Ono N, Ono W. A Hedgehog-Foxf axis coordinates dental follicle-derived alveolar bone formation. Nat Commun. 2025.07; 16 (1): 6061. ( PubMed, DOI )

  3. Tokavanich N, Chan B, Strauss K, Andrade CDC, Arai Y, Nagata M, Foretz M, Brooks DJ, Ono N, Ono W, Wein MN. Control of alveolar bone development, homeostasis, and socket healing by salt inducible kinases. Journal of Bone and Mineral Research. 2025.05; 40 (5): 656-670. ( PubMed, DOI )

  4. Li XX, Wang MT, Wu ZF, Sun Q, Ono N, Nagata M, Zang XL, Ono W. Etiological Mechanisms and Genetic/Biological Modulation Related to PTH1R in Primary Failure of Tooth Eruption. Calcif Tissue Int. 2024.08; 115 (2): 101-116. ( PubMed, DOI )

  5. Yuki Matsushita, Hiroaki Manabe, Takahiro Ohyama, Shogo Nakamura, Mizuki Nagata, Wanida Ono, Noriaki Ono. Hes1 marks peri-condensation mesenchymal cells that generate both chondrocytes and perichondrial cells in early bone development. J Biol Chem. 2023.06; 299 (6): 104805. ( PubMed, DOI )

  6. Yuki Matsushita, Jialin Liu, Angel Ka Yan Chu, Chiaki Tsutsumi-Arai, Mizuki Nagata, Yuki Arai, Wanida Ono, Kouhei Yamamoto, Thomas L Saunders, Joshua D Welch, Noriaki Ono. Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis. Nat Commun. 2023.04; 14 (1): 2383. ( PubMed, DOI )

  7. Yuki Matsushita, Angel Ka Yan Chu, Chiaki Tsutsumi-Arai, Shion Orikasa, Mizuki Nagata, Sunny Y Wong, Joshua D Welch, Wanida Ono, Noriaki Ono. The fate of early perichondrial cells in developing bones. Nat Commun. 2022.11; 13 (1): 7319. ( PubMed, DOI )

  8. Mizuki Nagata, Jeryl D English, Noriaki Ono, Wanida Ono. Diverse stem cells for periodontal tissue formation and regeneration. Genesis. 2022.09; 60 (8-9): e23495. ( PubMed, DOI )

  9. Mizuki Nagata, Angel Ka Yan Chu, Noriaki Ono, Joshua D Welch, Wanida Ono. Single-Cell Transcriptomic Analysis Reveals Developmental Relationships and Specific Markers of Mouse Periodontium Cellular Subsets. Front Dent Med. 2021.08; 2 ( PubMed, DOI )

  10. Shawn A Hallett, Yuki Matsushita, Wanida Ono, Naoko Sakagami, Koji Mizuhashi, Nicha Tokavanich, Mizuki Nagata, Annabelle Zhou, Takao Hirai, Henry M Kronenberg, Noriaki Ono. Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment. Elife. 2021.07; 10 ( PubMed, DOI )

  11. Mizuki Nagata, Noriaki Ono, Wanida Ono. Unveiling diversity of stem cells in dental pulp and apical papilla using mouse genetic models: a literature review. Cell Tissue Res. 2021.02; 383 (2): 603-616. ( PubMed, DOI )

  12. Kengo Iwasaki, Keiko Akazawa, Mizuki Nagata, Motohiro Komaki, Yihao Peng, Makoto Umeda, Tetsuro Watabe, Ikuo Morita. Angiogenic Effects of Secreted Factors from Periodontal Ligament Stem Cells. Dent J (Basel). 2021.01; 9 (1): ( PubMed, DOI )

  13. Shogo Maekawa, Mizuki Nagata, Yuki Matsushita, R Shane Tubbs, Joe Iwanaga. An unusual anatomical variation of the inferior alveolar nerve. Anat Cell Biol. 2020.12; 53 (4): 519-521. ( PubMed, DOI )

  14. Shinta Suzuki, Akira Aoki, Sayaka Katagiri, Shogo Maekawa, Kenichiro Ejiri, Sophannary Kong, Mizuki Nagata, Yoko Yamaguchi, Mitsuhiro Ohshima, Yuichi Izumi. Detection of hepatocyte growth factor in oral rinses using water for possible periodontal diagnosis. J Oral Sci. 2020.06; 62 (3): 250-255. ( PubMed, DOI )

  15. Joe Iwanaga, Mahindra Kumar Anand, Mitesh N Jain, Mizuki Nagata, Yuki Matsushita, Soichiro Ibaragi, Jingo Kusukawa, R Shane Tubbs. Microsurgical Anatomy of the Superior Wall of the Mandibular Canal and Surrounding Structures: Suggestion for New Classifications for Dental Implantology. Clin Anat. 2020.03; 33 (2): 223-231. ( PubMed, DOI )

  16. Nicha Tokavanich, Aditi Gupta, Mizuki Nagata, Akira Takahashi, Yuki Matsushita, Marilia Yatabe, Antonio Ruellas, Lucia Cevidanes, Koutaro Maki, Tetsutaro Yamaguchi, Noriaki Ono, Wanida Ono. A three-dimensional analysis of primary failure of eruption in humans and mice. Oral Dis. 2020.03; 26 (2): 391-400. ( PubMed, DOI )

  17. M Nagata, N Ono, W Ono. Mesenchymal Progenitor Regulation of Tooth Eruption: A View from PTHrP. J Dent Res. 2020.02; 99 (2): 133-142. ( PubMed, DOI )

  18. Yuki Matsushita, Mizuki Nagata, Kenneth M Kozloff, Joshua D Welch, Koji Mizuhashi, Nicha Tokavanich, Shawn A Hallett, Daniel C Link, Takashi Nagasawa, Wanida Ono, Noriaki Ono. A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration. Nat Commun. 2020.01; 11 (1): 332. ( PubMed, DOI )

  19. Shigeki Nishimori, Maureen J O'Meara, Christian D Castro, Hiroshi Noda, Murat Cetinbas, Janaina da Silva Martins, Ugur Ayturk, Daniel J Brooks, Michael Bruce, Mizuki Nagata, Wanida Ono, Christopher J Janton, Mary L Bouxsein, Marc Foretz, Rebecca Berdeaux, Ruslan I Sadreyev, Thomas J Gardella, Harald Jüppner, Henry M Kronenberg, Marc N Wein. Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling. J Clin Invest. 2019.12; 129 (12): 5187-5203. ( PubMed, DOI )

  20. Kengo Iwasaki, Motohiro Komaki, Keiko Akazawa, Mizuki Nagata, Naoki Yokoyama, Tetsuro Watabe, Ikuo Morita. Spontaneous differentiation of periodontal ligament stem cells into myofibroblast during ex vivo expansion. J Cell Physiol. 2019.11; 234 (11): 20377-20391. ( PubMed, DOI )

  21. Kengo Iwasaki, Mizuki Nagata, Keiko Akazawa, Tetsuro Watabe, Ikuo Morita. Changes in characteristics of periodontal ligament stem cells in spheroid culture. J Periodontal Res. 2019.08; 54 (4): 364-373. ( PubMed, DOI )

  22. Koji Mizuhashi, Mizuki Nagata, Yuki Matsushita, Wanida Ono, Noriaki Ono. Growth Plate Borderline Chondrocytes Behave as Transient Mesenchymal Precursor Cells. J Bone Miner Res. 2019.08; 34 (8): 1387-1392. ( PubMed, DOI )

  23. Akira Takahashi, Mizuki Nagata, Aditi Gupta, Yuki Matsushita, Tetsutaro Yamaguchi, Koji Mizuhashi, Koutaro Maki, Antonio C Ruellas, Lucia S Cevidanes, Henry M Kronenberg, Noriaki Ono, Wanida Ono. Autocrine regulation of mesenchymal progenitor cell fates orchestrates tooth eruption. Proc Natl Acad Sci U S A. 2019.01; 116 (2): 575-580. ( PubMed, DOI )

  24. Kengo Iwasaki, Keiko Akazawa, Mizuki Nagata, Motohiro Komaki, Izumi Honda, Chikako Morioka, Naoki Yokoyama, Hirohito Ayame, Kazumasa Yamaki, Yuichi Tanaka, Tsuyoshi Kimura, Akio Kishida, Tetsuro Watabe, Ikuo Morita. The Fate of Transplanted Periodontal Ligament Stem Cells in Surgically Created Periodontal Defects in Rats. Int J Mol Sci. 2019.01; 20 (1): ( PubMed, DOI )

  25. Nagata M, Iwasaki K, Akazawa K, Komaki M, Yokoyama N, Izumi Y, Morita I. Conditioned Medium from Periodontal Ligament Stem Cells Enhances Periodontal Regeneration. Tissue Eng Part A. 2017.05; 23 (9-10): 367-377. ( PubMed, DOI )

  26. Keiko Akazawa, Kengo Iwasaki, Mizuki Nagata, Naoki Yokoyama, Hirohito Ayame, Kazumasa Yamaki, Yuichi Tanaka, Izumi Honda, Chikako Morioka, Tsuyoshi Kimura, Motohiro Komaki, Akio Kishida, Yuichi Izumi, Ikuo Morita. Cell transfer technology for tissue engineering. Inflamm Regen. 2017; 37 21. ( PubMed, DOI )

  27. Nagata M, Nagata M, Kanie T, Shima K. Clinical and Histologic Aspects of Cervical Cemental Tear as a Risk for Periodontal Diseases. Clinical Advances in Periodontics. 2016.11; 6 (4): 167-174.

  28. Keiko Akazawa, Kengo Iwasaki, Mizuki Nagata, Naoki Yokoyama, Hirohito Ayame, Kazumasa Yamaki, Yuichi Tanaka, Izumi Honda, Chikako Morioka, Tsuyoshi Kimura, Motohiro Komaki, Akio Kishida, Yuichi Izumi, Ikuo Morita. Double-layered cell transfer technology for bone regeneration. Sci Rep. 2016.09; 6 33286. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Nagata M, Ono N, Ono W. CXCL12+ apical papilla mesenchymal progenitor cells drive tooth root formation . 2025 Internatonal Association for Dental Research (IADR) General Session 2025.06.28 Barcelona, Spain

  2. Nagata M. Wnt-directed CXCL12-expressing apical papilla mesenchymal progenitor cells drive tooth root formation. The 2024 Rolanette and Berdon Lawrence Bone Disease Program of Texas, Bone Research Conference 2024.04.19 Houston, USA

  3. Nagata M. Wnt-directed CXCL12-expressing apical papilla mesenchymal progenitor cells drive tooth root formation. Gordon Research Conference, Bone and Teeth 2024.01.30 Galveston, USA

  4. Mizuki Nagata. The mesenchymal cells derived from dental follicle contribute to periodontal regeneration . University of Texas Health Science Center at Houston School of Dentistry 13th Annual Research Showcase 2023.10.31 Houston, USA

  5. Mizuki Nagata. Dental Follicle Regulates Periodontium Formation via a Hedgehog-Dependent Mechanism. American Association for Dental, Oral & Craniofacial Research (AADOCR) Annual Meeting 2023.03.18 Portland, USA

  6. Mizuki Nagata. Single-cell Transcriptomic Analysis Reveals Developmental Relationships and Specific Markers of Mouse Periodontium Cellular Subsets. 3rd Annual GCC Single Cell Omics Symposium 2022.10.26

  7. Nagata M, Ono N, Ono W. PTHrP-expressing Dental Follicle Regulates Alveolar Bone Formation in a Hedgehog Signaling-Dependent Mechanism. The American Society for Bone and Mineral Research (ASBMR) 2022 Annual Meeting 2022.09.12 Austin, USA

  8. Nagata M, Chu AKY, Welch JD, Ono W. Single-cell transcriptomes reveal mesenchymal cellular diversity in mouse periodontium. International Association for Dental Research (IADR) General Session 2021.07.24

  9. Nagata M, Ono N, Ono W. Hedgehog signaling regulates fates of dental follicle mesenchymal progenitor cells. American Association for Dental Research and International Association for Dental Research (AADR/IADR) 2019.06.22

  10. Maekawa S, Suzuki S, Aoki A, Katagiri S, Ikeda Y, Ejiri K, Kong S, Nagata M, Yamaguchi Y, Ohshima M, Izumi Y. A new screening system for periodontitis using Hepatocyte growth factor. 104th Annual Meeting of American Academy of Periodontology 2018.10.29 Vancouver

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Awards & Honors 【 display / non-display 】

  • Best Poster Award for the Postdoc Category (Nagata M)，The 2024 Rolanette and Berdon Lawrence Bone Disease Program of Texas, Bone Research Conference，2024.04

  • Travel award for selected abstracts (Nagata M)，Gordon Research Conference, Bone and Teeth，2024.01

  • Sunstar Young Investigator Award (Nagata M)，The Japanese Society of Periodontology，2016.10

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