Conference Activities & Talks -

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  1. Jia Chunyan, Yoshioka Kotaro, Su Su Lei Mon , Katsuyama Maho, Tanaka-Yoshida Kie, Nagata Tetsuya, Yokota Takanori. Hetereoduplex oligonucleotiedeによるCSFを介した各種急性中枢神経毒性の軽減効果(Hetereoduplex oligonucleotiede mitigates various types of acute CNS toxicities via CSF route). 臨床神経学 2021.09.01

  2. Su Su Lei Mon , Yoshioka Kotaro, Jia Chunyan, Kunieda Taiki, Asami Yutaro, Yoshida-Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. オーバーハング2本鎖核酸の脳室内投与による効果増強と毒性の緩和(Overhanging duplex oligonucleotide enhances potency and mitigates toxicity intracerebroventricularly). 臨床神経学 2021.09.01

  3. Jia Chunyan, Yoshioka Kotaro, Mon Su Su Lei, Tanaka Kie, Nagata Tetsuya, Yokota Takanori. CNS疾患に対するヘテロ二重鎖オリゴヌクレオチド使用による治療指標の改善(Hetereoduplex oligonucleotides technology improves therapeutic index for CNS diseases). 臨床神経学 2020.11.01

  4. Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. オーバーハングしたヘテロ二重鎖オリゴヌクレオチドを用いたFAPのトランスフェリンを介した送達による治療(Treatment for FAP with overhanging heteroduplex oligonucleotides by transferrin-mediated delivery). 臨床神経学 2020.11.01

  5. Yoshioka Kotaro, Su Su Lei Mon , Jia Chunyan, Yamada Hiroki, Asami Yutaro, Tanaka Kie, Wenying Piao, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. CNSを標的としたオーバーハングヘテロ二2本鎖核酸を用いた新しいアンチセンスオリゴヌクレオチド治療(A novel antisense oligonucleotide therapy by overhanging heteroduplex oligonucleotide targeting CNS). 臨床神経学 2019.11.01

  6. 1. Yoshioka K, Kunieda T, Asami Y, Huijia G, Miyata H, Tanaka K, Sujino Y, Piao W, Kuwahara H, Nishina K, Iwata-Hara R, Nagata T, Wada T, Obika S, Yokota T. . Heteroduplex-oligonucleotides for highly efficient silencing of microRNA through a novel intracellular mechanism. 15th Annual Meeting of the Oligonucleotide Therapeutics Society 2019.10.16

  7. Mon Su Su Lei, Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. アンチセンスオリゴヌクレオチド二本鎖の新しい構造は脳室内経路を介した効果を改善する(A novel structure of duplex antisense oligonucleotides improves potency via intraventricular route). 臨床神経学 2018.12.01

  8. Yoshioka Kotaro, Kunieda Taiki, Asami Yutaro, Guo Huija, Enomoto Seiya, Miyata Haruka, Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. 新しい種類の二本鎖オリゴヌクレオチドはin vivoにおいてmicroRNAサイレンシングの効力を増強する(A new class of double-stranded oligonucleotide enhances in vivo potency of microRNA silencing). 臨床神経学 2018.12.01

  9. Kotaro Yoshioka, Taiki Kunieda, Yutaro Asami, Yumiko Sujino, Kie Tanaka, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Tetsuya Nagata and Takanori Yokota. Dual overhanging-duplex oligonucleotide improved efficacy and safety in gene therapy for FAP. XX Ⅲ World Congress of Neurology 2017.09.20 Kyoto, JPN

  10. Nishina Kazutaka, Yoshioka Kotaro, Nishina Tomoko, Kuwahara Hiroya, Nagata Tetsuya, Yokota Takanori. DNA/RNAヘテロ二本鎖構造に基づく新規オリゴヌクレオチド(Novel oligonucleotide based on DNA/RNA heteroduplex structures). 臨床神経学 2016.12.01

  11. Yoshioka Kotaro, Kunieda Taiki, Tanaka Kie, Piao Wenying, Kuwahara Hiroya, Nishina Kazutaka, Nagata Tetsuya, Yokota Takanori. 新型の二本鎖構造はFAPに対するアンチセンスオリゴヌクレオチドの効能を改善させる(A new type of double-stranded structure improved potency of antisense oligonucleotide for FAP). 臨床神経学 2016.12.01

  12. Li Fuying, Ishibashi Satoru, Yoshioka Kotaro, Wada Takehiko, Ichijo Masahiko, Iwasawa Eri, Song Jindong, Zhang Yongquan, Yokota Takanori. ヘテロ二重鎖オリゴヌクレオチドはマウス局所脳虚血において遺伝子発現を低下させる(Heteroduplex oligonucleotide reduced gene expression in focal ischemic brain in mice). 臨床神経学 2016.12.01

  13. 吉岡 耕太郎, 筋野 裕美子, 國枝 泰希, 下 剛典, 田中 規恵, 朴 文英, 桑原 宏哉, 仁科 一隆, 小比賀 聡, 横田 隆徳. Hetero-chimera-duplex-oligonucleotideによるエクソンスキッピング療法の開発(Development of exon-skipping therapy by hetero-chimera-duplex oligonucleotide). 臨床神経学 2015.12.01

  14. Kotaro Yoshioka, Yumiko Sujino, Kie Tanaka, Wenying Piao, Tomoko Nishina, Hiroya Kuwahara, Kazutaka Nishina, Takanori Yokota.. Hetero-chimera-duplex oligonucleotide (HCDO): A new class of oligonucleotide for enhancement of efficacy of microRNA inhibitor.. 10th annual meeting of the Oligonucleotide Therapeutics Society. 2014.10.12 San Diego.

  15. Kotaro Yoshioka, Kie Tanaka, Wenying Piao, Kazutaka Nishina, Takanori Yokota.. A new class of oligonucleotide drug; DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing.. 6th TMDU International Summer Program (ISP2014). 2014.08.26

  16. 吉岡 耕太郎, 渡邉 耕介, 日詰 正樹, 金澤 俊郎, 石橋 哲, 田中 宏明, 横田 隆徳, 水澤 英洋. 虚血性脳卒中患者における発作性心房細動に関する簡易スコア(A Simple Score For Paroxysmal Atrial Fibirillation in Ischemic Stroke Patients). 臨床神経学 2013.12.01

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