論文・総説 - 日比谷　秀爾

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  1. Shuji Hibiya, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Nobukatsu Horita, Sho Watanabe, Tomoaki Shirasaki, Ryu Nishimura, Natsuko Kimura, Tatsunori Nishimura, Noriko Gotoh, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids. J Crohns Colitis. 2017.05; 11 (5): 621-630. ( PubMed, DOI )

  2. Shuji Hibiya, Yusuke Matsuyama, Toshimitsu Fujii, Chiaki Maeyashiki, Eiko Saito, Kimiko Ito, Hiromichi Shimizu, Ami Kawamoto, Maiko Motobayashi, Kento Takenaka, Masakazu Nagahori, Masayuki Kurosaki, Tsunehito Yauchi, Kazuo Ohtsuka, Takeo Fujiwara, Ryuichi Okamoto, Mamoru Watanabe. 5-aminosalicylate-intolerant patients are at increased risk of colectomy for ulcerative colitis. Aliment Pharmacol Ther. 2021.01; 53 (1): 103-113. ( PubMed, DOI )

  3. Taku Kobayashi, Kei Moriya, Toshimitsu Fujii, Shigeki Bamba, Shinichiro Shinzaki, Akihiro Yamada, Takashi Hisabe, Shintaro Sagami, Shuji Hibiya, Takahiro Amano, Noritaka Takatsu, Katsutoshi Inagaki, Ken-Ichi Iwayama, Toshifumi Hibi. Early resolution of bowel urgency by budesonide foam enema results in improved quality of life in patients with ulcerative colitis: a multicenter prospective observational study. Intest Res. 2024.07; Online ahead of print ( PubMed, DOI )

  4. Hiromichi Shimizu, Yuko Aonuma, Shuji Hibiya, Ami Kawamoto, Kento Takenaka, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Ryuichi Okamoto. Long-term efficacy and safety of tofacitinib in patients with ulcerative colitis: 3-year results from a real-world study. Intest Res. 2024.07; 22 (3): 369-377. ( PubMed, DOI )

  5. Ami Kawamoto, Kento Takenaka, Shuji Hibiya, Yoshio Kitazume, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Kazuo Ohtsuka, Ryuichi Okamoto. Combination of leucine-rich alpha-2 glycoprotein and fecal markers detect Crohn's disease activity confirmed by balloon-assisted enteroscopy. Intest Res. 2023.11; Online ahead of print ( PubMed, DOI )

  6. Shuji Hibiya, Takashi Fujii, Toshimitsu Fujii, Shinji Suzuki, Mayumi Kondo, Shinya Ooka, Yohei Furumoto, Seishin Azuma, Kei Tanaka, Hitoshi Kurata, Shohei Tanaka, Masayuki Kurosaki, Kazuyoshi Nagayama, Fumihiko Kusano, Yasuhiro Iizuka, Takahiro Kawamura, Hidekazu Ikemiyagi, Shinya Sakita, Tsunehito Yauchi, Hideki Watanabe, Ami Kawamoto, Yusuke Matsuyama, Kazuo Ohtsuka, Ryuichi Okamoto. COVID-19 severity is associated with the risk of gastrointestinal bleeding. BMJ Open Gastroenterol. 2023.11; 10 (1): e001199. ( PubMed, DOI )

  7. Kento Takenaka, Ami Kawamoto, Yoshio Kitazume, Toshimitsu Fujii, Yumi Udagawa, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto. Transmural Remission Characterized by High Biologic Concentrations Demonstrates Better Prognosis in Crohn's Disease. J Crohns Colitis. 2023.06; 17 (6): 855-862. ( PubMed, DOI )

  8. Kento Takenaka, Yoshio Kitazume, Ami Kawamoto, Toshimitsu Fujii, Yumi Udagawa, Ryosuke Wanatabe, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Hiroyuki Sato, Akihiro Hirakawa, Mamoru Watanabe, Ryuichi Okamoto. Serum Leucine-Rich α2 Glycoprotein: A Novel Biomarker for Transmural Inflammation in Crohn's Disease. Am J Gastroenterol. 2023.06; 118 (6): 1028-1035. ( PubMed, DOI )

  9. Fujiwara S, Kawamoto A, Motobayashi M, Hibiya S, Takenaka K, Shimizu H, Saito E, Fujii T, Nagahori M, Kawata D, Umezawa N, Hosoya T, Yasuda S, Ohtsuka K, Okamoto R. Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab. DEN open. 2023.04; 3 (1): e196. ( PubMed, DOI )

  10. Eiko Saito, Kazuo Ohtsuka, Ami Kawamoto, Toshimitsu Fujii, Kento Takenaka, Shuji Hibiya, Hiromichi Shimizu, Masakazu Nagahori, Shohei Tomii, Ryuichi Okamoto. A case of venous stasis colitis possibly caused by eplerenone. Clin J Gastroenterol. 2023.02; 16 (1): 69-72. ( PubMed, DOI )

  11. Tsuchiya K, Nagahori M, Hanazawa R, Sasaki M, Sato H, Hirakawa A, Anzai T, Takahashi K, Kobayashi Y, Hibiya S, Takenaka K, Watanabe M. Serial daily recording of patient-reported outcomes (PRO2) might predict treatment change in the patients with Ulcerative Colitis. JOURNAL OF CROHNS & COLITIS. 2023.02; 17 (1): I316-I317.

  12. Shuji Hibiya, Kazuo Ohtsuka, Kento Takenaka, Ami Kawamoto, Yusuke Matsuyama, Yumi Udagawa, Maiko Motobayashi, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Ryuichi Okamoto, Mamoru Watanabe. Mucosal healing of small intestinal stricture is associated with improved prognosis post-dilation in Crohn's disease. BMC Gastroenterol. 2022.05; 22 (1): 218. ( PubMed, DOI )

  13. Hiromichi Shimizu, Toshimitsu Fujii, Kenji Kinoshita, Ami Kawamoto, Shuji Hibiya, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto. Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus. BMC Gastroenterol. 2021.12; 21 (1): 494. ( PubMed, DOI )

  14. Hiromichi Shimizu, Toshimitsu Fujii, Shuji Hibiya, Maiko Motobayashi, Kohei Suzuki, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe. Rapid prediction of 1-year efficacy of tofacitinib for treating refractory ulcerative colitis. Intest Res. 2020.06; Online ahead of print.. ( PubMed, DOI )

  15. Kento Takenaka, Toshimitsu Fujii, Kohei Suzuki, Hiromichi Shimizu, Maiko Motobayashi, Shuji Hibiya, Eiko Saito, Masakazu Nagahori, Mamoru Watanabe, Kazuo Ohtsuka. Small Bowel Healing Detected by Endoscopy in Patients With Crohn's Disease After Treatment With Antibodies Against Tumor Necrosis Factor. Clin. Gastroenterol. Hepatol.. 2019.08; ( PubMed, DOI )

  16. Sho Watanabe, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Nobuhiro Katsukura, Shuji Hibiya, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Mutation by CRISPR System Enhances the Malignant Potential of Colon Cancer. Mol. Cancer Res.. 2019.04; ( PubMed, DOI )

  17. Ryu Nishimura, Tomoaki Shirasaki, Kiichiro Tsuchiya, Yoshihide Miyake, Yusuke Watanabe, Shuji Hibiya, Sho Watanabe, Tetsuya Nakamura, Mamoru Watanabe. Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids. J. Gastroenterol.. 2019.01; ( PubMed, DOI )

  18. Ryohei Hayashi, Kiichiro Tsuchiya, Keita Fukushima, Nobukatsu Horita, Shuji Hibiya, Keisuke Kitagaki, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Shinji Fukuda, Hiroshi Ohno, Ryuichi Okamoto, Tetsuya Nakamura, Shinji Tanaka, Kazuaki Chayama, Mamoru Watanabe. Reduced Human α-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease. Inflamm. Bowel Dis.. 2016.05; 22 (5): 1119-1128. ( PubMed, DOI )

  19. Keita Fukushima, Kiichiro Tsuchiya, Yoshihito Kano, Nobukatsu Horita, Shuji Hibiya, Ryohei Hayashi, Keisuke Kitagaki, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Shigeru Oshima, Takashi Nagaishi, Okamoto Ryuichi, Tetsuya Nakamura, Mamoru Watanabe. Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. Cancer Sci. 2015.05; 106 (8): 1000-1007. ( PubMed, DOI )

  20. Nobukatsu Horita, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Shuji Hibiya, Masayoshi Fukuda, Yoshihito Kano, Tomohiro Mizutani, Yasuhiro Nemoto, Shiro Yui, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt. Biochem Biophys Res Commun. 2014.10; 454 (4): 493-499. ( PubMed, DOI )

  21. Tatsuro Murano, Ryuichi Okamoto, Go Ito, Toru Nakata, Shuji Hibiya, Hiromichi Shimizu, Satoru Fujii, Yoshihito Kano, Tomohiro Mizutani, Shiro Yui, Junko Akiyama-Morio, Yasuhiro Nemoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells. Biochem Biophys Res Commun. 2014.01; 443 (3): 840-846. ( PubMed, DOI )

  22. Yoshihito Kano, Kiichiro Tsuchiya, Xiu Zheng, Nobukatsu Horita, Keita Fukushima, Shuji Hibiya, Yuhki Yamauchi, Tatsunori Nishimura, Kunihiko Hinohara, Noriko Gotoh, Shinji Suzuki, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein. Biochem. Biophys. Res. Commun.. 2013.03; 432 (1): 175-181. ( PubMed, DOI )

  23. 日比谷 秀爾, 大塚 和朗, 岡本 隆一. 治療法の再整理とアップデートのために 専門家による私の治療 小腸腫瘍 日本医事新報. 2025.01; (5255): 46-47.

  24. 竹中 健人, 河本 亜美, 日比谷 秀爾, 大塚 和朗, 岡本 隆一. 小腸疾患に対する最新の内視鏡臨床、バルーン内視鏡を用いたクローン病モニタリング 臨牀消化器内科. 2024.11; 39 (12): 1529-1536.

  25. 大塚 和朗, 竹中 健人, 日比谷 秀爾, 河本 亜美, 齊藤 詠子, 田村 皓子, 張 肇豐, 岡本 隆一. 【小腸画像診断のトピックス】新しい小腸画像診断のトピックス 像強調観察 シングルバルーン内視鏡(NBI,TXI,RDI) 胃と腸. 2023.11; 58 (11): 1531-1536.

  26. 大塚 和朗, 竹中 健人, 日比谷 秀爾, 河本 亜美, 齊藤 詠子, 岡本 隆一. 【進化し続けるIEE】IEEを使いこなす 小腸内視鏡/カプセル内視鏡 バルーン内視鏡 IEEをどう活用するか 消化器内視鏡. 2023.03; 35 (3): 369-372. ( DOI 医中誌 )

  27. 大塚 和朗, 竹中 健人, 日比谷 秀爾, 福田 将義, 岡本 隆一. 【内視鏡データリファレンスブック2022】臓器別　十二指腸・小腸　小腸腫瘍 消化器内視鏡. 2022.04; 34 (4): 678-682. ( 医中誌 )

  28. 藤井 俊光, 日比谷 秀爾, 岡本 隆一, 渡辺 守. 【炎症性腸疾患update-診断・治療の最新知見-】炎症性腸疾患の治療　薬物治療　5-ASA製剤 日本臨床. 2022.03; 80 (3): 433-438. ( 医中誌 )

  29. 大塚 和朗, 竹中 健人, 齊藤 詠子, 日比谷 秀爾, 河本 亜美, 森川 亮, 藤井 俊光, 清水 寛路, 長堀 正和, 岡本 隆一 . 【炎症性腸疾患の粘膜治癒を再考する】Crohn病における小腸粘膜治癒評価の意義　バルーン内視鏡の立場から 胃と腸. 2022.02; 57 (2): 173-181. ( 医中誌 )

  30. 日比谷 秀爾, 藤井 俊光, 岡本 隆一. 【炎症性腸疾患診療の新たな展開】鑑別すべき腸疾患 臨牀と研究. 2021.05; 98 (5): 569-572. ( 医中誌 )

  31. 日比谷秀爾、藤井俊光、岡本隆一、渡辺守. 潰瘍性大腸炎における5-ASA不耐は予後不良である INTESTINE. 2021.05; 25 (1): 115-118.

  32. 大塚 和朗, 竹中 健人, 日比谷 秀爾. シングルバルーン内視鏡のコツ 消化器内視鏡. 2021.02; 33 (2): 374-375.

  33. 大塚和朗、竹中健人、藤井俊光、齊藤詠子、本林麻衣子、清水寛路、日比谷秀爾、長堀正和、土屋輝一郎、渡辺　守. 重症度評価と粘膜治癒の意義 消化器内視鏡. 2020.02; 32 (2): 256-261.

  34. 日比谷秀爾、土屋輝一郎、渡辺　守. 【特集： IBD関連大腸腫瘍の診断・治療update】長期炎症による大腸上皮培養細胞形質変化 INTESTINE. 2018.01; 22 (1): 91-94.

  35. 日比谷秀爾. 【トピックスワールドコングレスレポート】No.31_第24回欧州消化器病週間 ： 24th United European Gastroenterology Week (UEGW) 2016　（ 2016年10月15～19日,ウィーン,オーストリア） IBD Research. 2016.12; 10 (4): 241-244.

  36. 日比谷秀爾、土屋輝一郎、渡辺　守. 【話題の疾患と治療】炎症性腸疾患と発癌 感染・炎症・免疫. 2016.10; 46 (3): 246-248.

  37. 土屋輝一郎, 福島啓太, 日比谷秀爾, 加納嘉人. 【特集　下部消化管：炎症からの発癌】炎症発癌の基礎研究（３）炎症発癌の癌形質獲得機構 INTESTINE. 2015.08; 19 (4): 342-347.

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