競争的資金等の研究課題 【 表示 / 非表示 】
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Analysis on detrimental interplay between pathogenic helper T cells, inflammatory an tigen-presenting cells and disease-associated microglia in chronic pathogenesis of m ultiple sclerosis
文部科学省/日本学術振興会
論文・総説 【 表示 / 非表示 】
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Zhang Chenyang, Raveney Ben, Takahashi Fumio, Yeh Tzu-wen, Hohjoh Hirohiko, Yamamura Takashi, Oki Shinji. Pathogenic Microglia Orchestrate Neurotoxic Properties of Eomes-Expressing Helper T Cells CELLS. 2023.03; 12 (6): ( PubMed, DOI )
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Amrita Widyagarini, Naoto Nishii, Yohei Kawano, Chenyang Zhang, Miyuki Azuma. VSIG4/CRIg directly regulates early CD8+ T cell activation through its counter-receptor in a narrow window Biochem Biophys Res Commun. 2022.07; 614 100-106. ( PubMed, DOI )
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Takahashi F, Zhang C, Hohjoh H, Raveney B, Yamamura T, Hayashi N, Oki S. Immune-mediated neurodegenerative trait provoked by multimodal derepression of long-interspersed nuclear element-1. iScience. 2022.05; 25 (5): 104278. ( PubMed, DOI )
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Ben J E Raveney, Wakiro Sato, Daiki Takewaki, Chenyang Zhang, Tomomi Kanazawa, Youwei Lin, Tomoko Okamoto, Manabu Araki, Yukio Kimura, Noriko Sato, Terunori Sano, Yuko Saito, Shinji Oki, Takashi Yamamura. Involvement of cytotoxic Eomes-expressing CD4 + T cells in secondary progressive multiple sclerosis Proc Natl Acad Sci U S A. 2021.03; 118 (11): ( PubMed, DOI )
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Chenyang Zhang, Ben J E Raveney, Hirohiko Hohjoh, Chiharu Tomi, Shinji Oki, Takashi Yamamura. Extrapituitary prolactin promotes generation of Eomes-positive helper T cells mediating neuroinflammation. Proc Natl Acad Sci U S A. 2019.10; 116 (42): 21131-21139. ( PubMed, DOI )
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Ohno T, Zhang C, Kondo Y, Kang S, Furusawa E, Tsuchiya K, Miyazaki Y, Azuma M. The immune checkpoint molecule VISTA regulates allergen-specific Th2-mediated immune responses Int Immune. 2018.02; 30 (1): 3-11. ( PubMed, DOI )
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Ohno Tatsukuni, Zhang Chenyang, Kondo Yuta, Kang Siwen, Furusawa Emi, Tsuchiya Kimitake, Miyazaki Yasunari, Azuma Miyuki. 免疫チェックポイント分子であるVISTAはアレルゲン特異的Th2介在免疫反応を調節する(The immune checkpoint molecule VISTA regulates allergen-specific Th2-mediated immune responses) International Immunology. 2018.01; 30 (1): 3-11. ( 医中誌 )
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Ohno T, Kondo Y, Zhang C, Kang S, Azuma M. Immune checkpoint molecule, VISTA regulates T cell-mediated skin inflammatory responses Invest Dermatol ;In press. 2016.10; 137 (6): 1384-1386. ( PubMed, DOI )
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Kang S, Zhang C, Ohno T, Azuma M. Unique B7-H1 expression on masticatory mucosae in the oral cavity and trans-coinhibition by B7-H1-expressing keratinocytes regulating CD4+ T-cell-mediated mucosal tissue inflammation Mucosal Immunol. 2016.10; 12 (3): 650-660. ( PubMed, DOI )
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Chenyang Zhang, Tatsukuni Ohno, Siwen Kang, Toshiro Takai, Miyuki Azuma. Repeated antigen painting and sublingual immunotherapy in mice convert sublingual dendritic cell subsets. Vaccine. 2014.09; 32 (43): 5669-5676. ( PubMed, DOI )
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Sunthamala N, Pientong C, Ohno T, Zhang C, Bhingare A, Kondo Y, Azuma M, Ekalaksananan T. HPV16 E2 protein promotes innate immunity by modulating immunosuppressive status. Biochemical and biophysical research communications. 2014.04; 446 (4): 977-82. ( PubMed, DOI )
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Bhingare AC, Ohno T, Tomura M, Zhang C, Aramaki O, Otsuki M, Tagami J, Azuma M. Dental pulp dendritic cells migrate to regional lymph nodes. Journal of dental research. 2014.03; 93 (3): 288-93. ( PubMed, DOI )
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Chenyang Zhang, Dapeng Wei, Zhijuan Luo, Yanjun Liu, Tingting Liao, Chongjie Zhang. Synthetic peptide coupled to KLH elicits antibodies against beta8 integrin. Hybridoma (Larchmt). 2010.08; 29 (4): 361-366. ( PubMed, DOI )
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東 みゆき、Yang Yue、張 晨陽、永井 重徳. 口腔粘膜の免疫寛容 臨床免疫・アレルギー科. 2022.01; 77 (1): 25-30.
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東 みゆき, 楊 げつ, 張 晨陽, 永井 重徳. 【免疫寛容】口腔粘膜の免疫寛容 臨床免疫・アレルギー科. 2022.01; 77 (1): 25-30. ( 医中誌 )
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Ting-Ting Liao, Chen-Yang Zhang, Xiao-Mei Jiang, Da-Peng Wei, Chong-Jie Zhang. [Preparation and identification of a monoclonal antibody against recombinant human L-type pyruvate kinase N]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2010.07; 41 (4): 571-574. ( PubMed )
講演・口頭発表等 【 表示 / 非表示 】
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Amrita Widyagarini, Yohei Kawano, Chenyang Zhang, Miyuki Azuma. VSIG4/CRIg, a new B7 family ligand, directly regulates early CD8+ T cell activation through its counter-receptor in a narrow window. 第51回日本免疫学会 2022.12.07 熊本
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Zhang Chenyang, Sultana Farzana, Nagai Shigenori, Azuma Miyuki. T cell function and diseases-1(Disease models and SARS-CoV-2)(Elevated expression of a novel immune checkpoint molecule, ILDR2 in inflammatory brain). 日本免疫学会総会・学術集会記録 2022.11.01
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Widyagarini Amrita, Kawano Yohei, Zhang Chenyang, Azuma Miyuki. Tolerance and Immune suppression-2(VSIG4/CRIg, a new B7 family ligand, Directly regulates early CD8+ T cell activation through its counter-receptor in a narrow window). 日本免疫学会総会・学術集会記録 2022.11.01
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Yeh Tzu wen, Zhang Chenyang, Raveney Ben, Takahashi Fumio, Prinz Marco, Yamamura Takashi, Oki Shinji. T cell function and diseases-1(Disease models and SARS-CoV-2)(Induction of Eomes-expressing Th cells via upregulation of type I interferon). 日本免疫学会総会・学術集会記録 2022.11.01
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Widyagarini Amrita, 張 晨陽, 東 みゆき. 新規B7ファミリー免疫チェックポイントリガンドVSIG4は、カウンターレセプターを介して早期のCD8+T細胞活性化を抑制する(VSIG4, a new B7 family immune checkpoint ligand, directly regulates early CD8 + T cell activation through its counter-receptor). Journal of Oral Biosciences Supplement 2022.09.01
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張 晨陽, 奥原 滋, 永井 重徳, 東 みゆき. 新規免疫チェックポイント分子ILDR2の発現(The expression of novel immune checkpoint molecule ILDR2). Journal of Oral Biosciences Supplement 2022.09.01
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Nagatomo Yuto, Zhang Chenyang, Widyagarini Amrita, Azuma Miyuki. マウスSCC腫瘍細胞における細胞表面ILDR2の誘導は抗腫瘍T細胞応答を制御する(The induction of cell surface ILDR2 in murine SCC tumor cells regulates antitumor T-cell responses). 日本免疫学会総会・学術集会記録 2021.11.01
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Li Huixin, Yasuda Shunichiro, Aoyama Satoru, Zhang Chenyang, Kawano Yohei, Efa Bemard Bahaah Akwasi, Azuma Miyuki, Kawamata Norihiko. CD80は慢性骨髄性白血病幹細胞のマーカーとなり得、BCR-ABLシグナル伝達によって制御されている(CD80 can be the marker of chronic myeloid leukemia stem cells and regulated by BCR-ABL signaling). 日本血液学会学術集会 2021.09.01
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L Huixin, S Yasuda, S Aoyama, C Zhang, Y Kawano, M Azuma, N Kawamata . CD80 can be the marker of chronic myeloid leukemia stem cells and regulated by BCR-ABL signaling. AACR Annual Meeting 2021 2021.04.10 U.S.A (Web)
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Zhang Chenyang, Raveney Ben J.E., Yamamura Takashi, Oki Shinji. 臓器特異的自己免疫疾患 小膠細胞由来I型インターフェロンは異所性のプロラクチン産生を誘導して慢性神経炎を促進する(Organ-specific autoimmune diseases Microglia-derived type I interferons promote chronic neuroinflammation by inducing ectopic prolactin production). 日本免疫学会総会・学術集会記録 2019.11.01
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Oki Shinji, Zhang Chenyang, Yamamura Takashi, Raveney Ben J.E.. 全身性自己免疫疾患 NR4A2はin vivoでの自己反応性Th反応の進行をコントロールする(Systemic autoimmune diseases-1 NR4A2 controls the development of self-reactive Th responses in vivo). 日本免疫学会総会・学術集会記録 2018.12.01
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Zhang Chenyang, Raveney Ben J.E., Oki Shinji, Yamamura Takashi. 組織特異的免疫疾患 下垂体外prolactinは慢性神経炎症を媒介するEomes陽性ヘルパーT細胞の産生を促進する(Tissue-specific immune diseases-1 Extrapituitary prolactin promotes the generation of Eomes-positive helper T cells mediating chronic neuroinflammation). 日本免疫学会総会・学術集会記録 2018.12.01
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Yamamura Takashi, Raveney Ben J.E., Zhang Chenyang, Oki Shinji. 神経免疫とエフェクターT細胞 急性神経炎症から慢性神経炎症への切り替え Eomes発現Th細胞の役割(Neuroimmunology and effector T cells The switch from acute to chronic neuroinflammation: Role of Eomes-expressing Th cells). 日本免疫学会総会・学術集会記録 2018.12.01
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Tomi Chiharu, Raveney Ben, Zhang Chenyang, Yamamura Takashi, Oki Shinji. 全身性自己免疫疾患(1) ループス易発症マウスにおける自己反応性ヘルパーT細胞の病原特性に対するNR4A2の役割(Systemic autoimmune disease(1) Roles of NR4A2 for pathogenic properties of autoreactive T helper cells in lupus-prone mice). 日本免疫学会総会・学術集会記録 2017.12.01
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ZHANG Chenyang, RAVENEY Benjamin, TOMI Chiharu, OKI Shinji, YAMAMURA Takashi. 組織特異的免疫疾患(I) 抗原提示細胞は慢性神経炎症下のprolactin異所性発現を通してヘルパーT細胞におけるEomes発現を促進する(Tissue-specific immune diseases(I) Antigen-presenting cells promote Eomes expression in helper T cells through ectopic expression of prolactin under chronic neuroinflammation). 日本免疫学会総会・学術集会記録 2017.12.01
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Azuma M, Kang S, Ohno T, Zhang C. Unique Sublingual Dendritic Cell State Induces Tolerance by Sublingual Immunotherapy.. IADR2016 2016.06.22 Seoul, Korea
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Azuma M, Zhang C, Kang S, Ohno T. Protective roles of PD-1:PD-1 pathway in a murine model of pollen allergy. Fundamental Immunology and Its Therapeutic Potential 2015 2015.04.14 NY.USA
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Kang S, Zhang C, Ohno T, Azuma M. Constitutive expression of co-inhibitory molecule B7-H1(CD274)in masticatory mucosa. 第43回日本免疫学会 2014.12.12 京都
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Kondo Y, Ohno T, Zhang C, Yagita H, Harada K, Azuma M. Anti-tumor effects of mAb against a new immune-checkpoint molecule VISTA/PD-1H. 第43回日本免疫学会 2014.12.12 京都
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Worawalun H, Zhang C, OhnoT, Kang S, Takai T, AzumaM. Repeated antigen painting and sublingual immunotherapy convert sublingual dendritic cell subsets. 第43回日本免疫学会 2014.12.12 京都
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Zhang C, Kang S, Ohno T, Azuma M. PD-1 and/or B7-H1 deficiency in a Japanese Cedar Pollinosis model. 第43回日本免疫学会 2014.12.10 京都
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近藤 雄太、大野 建州、張 晨陽、八木田 秀雄、原田 清、東 みゆき. Anti-tumor effects of mAb against a new immune-checkpoint molecule VISTA. 第73回日本癌学会 2014.09.25 横浜
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Zhang C, Ohno T, Kang S, Bhingare AC, Takai T, Azuma M. Repeated antigen painting and sublingual immunotherapy convert sublingual dendritic cell populations. 13th International Symposium on Dendritic cells 2014.09.14 Tours, France
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Bhingare AC, Ohno T, Tomura M, Zhang C, Azuma M. Demonstration of dental pulp DC migration to regional Lymph nodes using photoconvertible fluorescent protein transduced mice. 13th International Symposium on Dendritic cells 2014.09.14 Tours, France
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Chenyang Zhang, Farzana Sultana, Shigenori Nagai, Miyuki Azuma. Elevated expression of a novel immune checkpoint molecule, ILDR2 in inflammatory brain. 第51回日本免疫学会 2022.12.07 熊本
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Tzu Wen Yeh, Chenyang Zhang, Ben Raveney, Fumio Takahashi, Marco Prinz, Takashi Yamamura, Shinji Ok. Induction of Eomes-expressing Th cells via upregulation of type I interferon. 第51回日本免疫学会 2022.12.07 熊本
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Farzana Sultana, Chenyang Zhang, Shigeru Okuhara, Sigenori Nagai, Miyuki Azuma. A novel immune checkpoint molecule, ILDR2 is upregulated in the inflammatory by brain.. 第87回口腔病学会 2022.12.02 東京
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大木 伸司, 張 晨陽, 北條 浩彦, レイバニー・ベン , 山村 隆, 林 宣宏, 高橋 文緒. その他 神経変性疾患の病態形成に関わる免疫依存性神経細胞障害の分子機序. 神経免疫学 2022.10.01
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張 晨陽、奥原 滋、 永井 重徳、 東 みゆき. 新規免疫チェクポイント分子ILDR2の発現. 第64回歯科基礎医学会学術大会 2022.09.18 徳島
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Widyagarini Amrita, 張 晨陽、 東 みゆき. 新規B7ファミリー免疫チェックポイントリガンドVSIG4は、カウンターレセプターを介して早期のCD8+T細胞活性化を抑制する. 第64回歯科基礎医学会 2022.09.18
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Yuto Nagatomo, Chenyang Zhang, Amrita Widyagarini, Miyuki Azuma. The induction of cell surface ILDR2 in murine SCC tumor cells regulates antitumor T-cell responses. 第50回日本免疫学会 2021.12.08 奈良 (ハイブリット開催)
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長友 優斗、張 晨陽、東 みゆき. 新規免疫チェックポイント分子ILDR2の抗腫瘍免疫応答における影響. 第25回日本がん免疫学会 2021.07.01 和歌山
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長友 優斗, 張 晨陽, 東 みゆき. 新規免疫チェックポイント分子ILDR2の抗腫瘍免疫応答における影響. 日本がん免疫学会総会プログラム・抄録集 2021.05.01
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大木 伸司, 張 晨陽, 山村 隆. 神経変性病態における免疫依存性神経細胞障害機序の解明. 神経免疫学 2020.10.01
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大木 伸司, 張 晨陽, 山村 隆. 神経変性病態に伴う慢性炎症環境の分子機序の解明. 神経免疫学 2020.10.01
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Kang S, Zhang C, Ohno T, Azuma M. Unique B7-H1 expression on masticatory mucosae and trans-coinhibition by B7-H1-expressing keratinocytes in CD4+ T-cell-mediated mucosal inflammation. The 5th Tri-University Consortium on Oral Science and Education 2016.10.27 Peking University, China
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Kang S, Zhang C, Ohno T, Azuma M. Unique B7-H1 expression on masticatory mucosae and trans-coinhibition by B7-H1-expressing keratinocytes in CD4+ T-cell-mediated mucosal inflammation. The 5th Tri-University Consortium on Oral Science and Education 2016.10.27 Peking University, China
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Azuma M, Kang S, Ohno T, Zhang C. Unique Sublingual Dendritic Cell State Induces Tolerance by Sublingual Immunotherapy.. IADR2016 2016.06.22 Seoul, Korea
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Azuma M, Kang S, Ohno T, Zhang C. Unique Sublingual Dendritic Cell State Induces Tolerance by Sublingual Immunotherapy.. IADR2016 2016.06.22 Seoul, Korea