基本情報

写真a

張 晨陽(チョウ シンヨウ)

ZHANG CHENYANG


職名

助教

出身大学院 【 表示 / 非表示

  • 東京医科歯科大学  分子免疫学  博士課程  2014年09月  修了

取得学位 【 表示 / 非表示

  • 博士(歯学)  東京医科歯科大学

経歴(学内) 【 表示 / 非表示

  • 2020年06月
    -
    現在
    東京医科歯科大学 大学院医歯学総合研究科 医歯学系専攻 口腔機能再構築学講座 分子免疫学 助教

所属学協会 【 表示 / 非表示

  • 日本多発性硬化症協会

  • 日本神経免疫学会

  • 日本癌学会

  • 日本免疫学会

研究分野 【 表示 / 非表示

  • 神経免疫学

  • 免疫学

 

競争的資金等の研究課題 【 表示 / 非表示

  • Analysis on detrimental interplay between pathogenic helper T cells, inflammatory an tigen-presenting cells and disease-associated microglia in chronic pathogenesis of m ultiple sclerosis

    文部科学省/日本学術振興会

論文・総説 【 表示 / 非表示

  1. Amrita Widyagarini, Naoto Nishii, Yohei Kawano, Chenyang Zhang, Miyuki Azuma. VSIG4/CRIg directly regulates early CD8+ T cell activation through its counter-receptor in a narrow window Biochem Biophys Res Commun. 2022.07; 614 100-106. ( PubMed, DOI )

  2. Fumio Takahashi, Chenyang Zhang, Hirohiko Hohjoh, Ben Raveney, Takashi Yamamura, Nobuhiro Hayashi, Shinji Oki. Immune-mediated neurodegenerative trait provoked by multimodal derepression of long-interspersed nuclear element-1. iScience. 2022.05; 25 (5): 104278. ( PubMed, DOI )

  3. Ben J E Raveney, Wakiro Sato, Daiki Takewaki, Chenyang Zhang, Tomomi Kanazawa, Youwei Lin, Tomoko Okamoto, Manabu Araki, Yukio Kimura, Noriko Sato, Terunori Sano, Yuko Saito, Shinji Oki, Takashi Yamamura. Involvement of cytotoxic Eomes-expressing CD4 + T cells in secondary progressive multiple sclerosis Proc Natl Acad Sci U S A. 2021.03; 118 (11): ( PubMed, DOI )

  4. Chenyang Zhang, Ben J E Raveney, Hirohiko Hohjoh, Chiharu Tomi, Shinji Oki, Takashi Yamamura. Extrapituitary prolactin promotes generation of Eomes-positive helper T cells mediating neuroinflammation. Proc Natl Acad Sci U S A. 2019.10; 116 (42): 21131-21139. ( PubMed, DOI )

  5. Ohno T, Zhang C, Kondo Y, Kang S, Furusawa E, Tsuchiya K, Miyazaki Y, Azuma M. The immune checkpoint molecule VISTA regulates allergen-specific Th2-mediated immune responses Int Immune. 2018.02; 30 (1): 3-11. ( PubMed, DOI )

  6. Ohno T, Kondo Y, Zhang C, Kang S, Azuma M. Immune checkpoint molecule, VISTA regulates T cell-mediated skin inflammatory responses Invest Dermatol ;In press. 2016.10; ( DOI )

  7. Kang S, Zhang C, Ohno T, Azuma M. Unique B7-H1 expression on masticatory mucosae in the oral cavity and trans-coinhibition by B7-H1-expressing keratinocytes regulating CD4+ T-cell-mediated mucosal tissue inflammation Mucosal Immunol. 2016.10; 12 ( DOI )

  8. Chenyang Zhang, Tatsukuni Ohno, Siwen Kang, Toshiro Takai, Miyuki Azuma. Repeated antigen painting and sublingual immunotherapy in mice convert sublingual dendritic cell subsets. Vaccine. 2014.09; 32 (43): 5669-5676. ( PubMed, DOI )

  9. 東 みゆき、Yang Yue、張 晨陽、永井 重徳. 口腔粘膜の免疫寛容 臨床免疫・アレルギー科. 2022.01; 77 (1): 25-30.

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講演・口頭発表等 【 表示 / 非表示

  1. Tzu Wen Yeh, Chenyang Zhang, Ben Raveney, Fumio Takahashi, Marco Prinz, Takashi Yamamura, Shinji Ok. Induction of Eomes-expressing Th cells via upregulation of type I interferon. 第51回日本免疫学会 2022.12.07 熊本

  2. Chenyang Zhang, Farzana Sultana, Shigenori Nagai, Miyuki Azuma. Elevated expression of a novel immune checkpoint molecule, ILDR2 in inflammatory brain. 第51回日本免疫学会 2022.12.07 熊本

  3. Amrita Widyagarini, Yohei Kawano, Chenyang Zhang, Miyuki Azuma. VSIG4/CRIg, a new B7 family ligand, directly regulates early CD8+ T cell activation through its counter-receptor in a narrow window. 第51回日本免疫学会 2022.12.07 熊本

  4. L Huixin, S Yasuda, S Aoyama, C Zhang, Y Kawano, M Azuma, N Kawamata . CD80 can be the marker of chronic myeloid leukemia stem cells and regulated by BCR-ABL signaling. AACR Annual Meeting 2021 2021.04.10 U.S.A (Web)

  5. Azuma M, Kang S, Ohno T, Zhang C. Unique Sublingual Dendritic Cell State Induces Tolerance by Sublingual Immunotherapy.. IADR2016 2016.06.22 Seoul, Korea

  6. Azuma M, Zhang C, Kang S, Ohno T. Protective roles of PD-1:PD-1 pathway in a murine model of pollen allergy. Fundamental Immunology and Its Therapeutic Potential 2015 2015.04.14 NY.USA

  7. Kang S, Zhang C, Ohno T, Azuma M. Constitutive expression of co-inhibitory molecule B7-H1(CD274)in masticatory mucosa. 第43回日本免疫学会 2014.12.12 京都

  8. Kondo Y, Ohno T, Zhang C, Yagita H, Harada K, Azuma M. Anti-tumor effects of mAb against a new immune-checkpoint molecule VISTA/PD-1H. 第43回日本免疫学会 2014.12.12 京都

  9. Worawalun H, Zhang C, OhnoT, Kang S, Takai T, AzumaM. Repeated antigen painting and sublingual immunotherapy convert sublingual dendritic cell subsets. 第43回日本免疫学会 2014.12.12 京都

  10. Zhang C, Kang S, Ohno T, Azuma M. PD-1 and/or B7-H1 deficiency in a Japanese Cedar Pollinosis model. 第43回日本免疫学会 2014.12.10 京都

  11. 近藤 雄太、大野 建州、張 晨陽、八木田 秀雄、原田 清、東 みゆき. Anti-tumor effects of mAb against a new immune-checkpoint molecule VISTA. 第73回日本癌学会 2014.09.25 横浜

  12. Zhang C, Ohno T, Kang S, Bhingare AC, Takai T, Azuma M. Repeated antigen painting and sublingual immunotherapy convert sublingual dendritic cell populations. 13th International Symposium on Dendritic cells 2014.09.14 Tours, France

  13. Bhingare AC, Ohno T, Tomura M, Zhang C, Azuma M. Demonstration of dental pulp DC migration to regional Lymph nodes using photoconvertible fluorescent protein transduced mice. 13th International Symposium on Dendritic cells 2014.09.14 Tours, France

  14. Farzana Sultana, Chenyang Zhang, Shigeru Okuhara, Sigenori Nagai, Miyuki Azuma. A novel immune checkpoint molecule, ILDR2 is upregulated in the inflammatory by brain.. 第87回口腔病学会 2022.12.02 東京

  15. 張 晨陽、奥原 滋、 永井 重徳、 東 みゆき. 新規免疫チェクポイント分子ILDR2の発現. 第64回歯科基礎医学会学術大会 2022.09.18 徳島

  16. Widyagarini Amrita, 張 晨陽、 東 みゆき. 新規B7ファミリー免疫チェックポイントリガンドVSIG4は、カウンターレセプターを介して早期のCD8T細胞活性化を抑制する. 第64回歯科基礎医学会 2022.09.18

  17. Yuto Nagatomo, Chenyang Zhang, Amrita Widyagarini, Miyuki Azuma. The induction of cell surface ILDR2 in murine SCC tumor cells regulates antitumor T-cell responses. 第50回日本免疫学会 2021.12.08 奈良 (ハイブリット開催)

  18. 長友 優斗、張 晨陽、東 みゆき. 新規免疫チェックポイント分子ILDR2の抗腫瘍免疫応答における影響. 第25回日本がん免疫学会 2021.07.01 和歌山

  19. Kang S, Zhang C, Ohno T, Azuma M. Unique B7-H1 expression on masticatory mucosae and trans-coinhibition by B7-H1-expressing keratinocytes in CD4+ T-cell-mediated mucosal inflammation. The 5th Tri-University Consortium on Oral Science and Education 2016.10.27 Peking University, China

  20. Kang S, Zhang C, Ohno T, Azuma M. Unique B7-H1 expression on masticatory mucosae and trans-coinhibition by B7-H1-expressing keratinocytes in CD4+ T-cell-mediated mucosal inflammation. The 5th Tri-University Consortium on Oral Science and Education 2016.10.27 Peking University, China

  21. Azuma M, Kang S, Ohno T, Zhang C. Unique Sublingual Dendritic Cell State Induces Tolerance by Sublingual Immunotherapy.. IADR2016 2016.06.22 Seoul, Korea

  22. Azuma M, Kang S, Ohno T, Zhang C. Unique Sublingual Dendritic Cell State Induces Tolerance by Sublingual Immunotherapy.. IADR2016 2016.06.22 Seoul, Korea

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