Personnel Information

写真a

MATSUZAWA Yu


Job title

Associate Professor

Laboratory Phone number

+81-3-5803-5375

Mail Address

matsuzawa.yu@tmd.ac.jp

Research Areas, Keywords

IBD, Paneth cell, autophagy, cell death, stress
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Graduating School 【 display / non-display 】

  • Nagoya City University, Faculty of Medicine, 2007.03, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School, Division of Medical Sciences, Doctor's Course, 2014.03, Accomplished credits for doctoral program

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Campus Career 【 display / non-display 】

  • 2016.06
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Gastroenterology and Hepatology， Visiting Lecturer
  • 2017.05
    -
    2023.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Gastroenterology and Hepatology， Visiting Lecturer
  • 2023.04
    -
    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Biomedical Sciences and Engineering， Division of Biomedical Laboratory Sciences， Department of Clinical and Diagnostic Laboratory Science， Associate Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Biomedical Laboratory Sciences， Department of Clinical and Diagnostic Laboratory Science， Associate Professor
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External Career 【 display / non-display 】

  • 2015.08
    -
    2023.03
    New York University School of Medicine, Department of Microbiology, Postdoctoral Fellow
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Research Areas 【 display / non-display 】

  • Experimental pathology

  • Molecular biology

  • Immunology

  • Gastroenterology

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Qualification Acquired 【 display / non-display 】

  • Doctor

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Published Papers & Misc 【 display / non-display 】

  1. The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death. 2022.10; 610 (7932): 547-554. ( PubMed, DOI )

  2. An intestinal organoid-based platform that recreates susceptibility to T-cell-mediated tissue injury. 2020.06; 135 (26): 2388-2401. ( PubMed, DOI )

  3. Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer. 2020.04; 130 (4): 2111-2128. ( PubMed, DOI )

  4. IFN-I and IL-22 mediate protective effects of intestinal viral infection. 2019.10; 4 (10): 1737-1749. ( PubMed, DOI )

  5. Yu Matsuzawa-Ishimoto, Yusuke Shono, Luis E Gomez, Vanessa M Hubbard-Lucey, Michael Cammer, Jessica Neil, M Zahidunnabi Dewan, Sophia R Lieberman, Amina Lazrak, Jill M Marinis, Allison Beal, Philip A Harris, John Bertin, Chen Liu, Yi Ding, Marcel R M van den Brink, Ken Cadwell. Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium. J. Exp. Med. 2017.12; 214 (12): 3687-3705. ( PubMed, DOI )

  6. Yu Matsuzawa-Ishimoto, Seungmin Hwang, Ken Cadwell. Autophagy and Inflammation. Annu. Rev. Immunol.. 2017.11; 36 73-101. ( PubMed, DOI )

  7. Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe. Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62. Autophagy. 2017.11; 14 (2): 1-43. ( PubMed, DOI )

  8. Chiaki Maeyashiki, Shigeru Oshima, Kana Otsubo, Masanori Kobayashi, Yoichi Nibe, Yu Matsuzawa, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells. Biochem. Biophys. Res. Commun. 2017.03; 484 (3): 636-641. ( PubMed, DOI )

  9. Masanori Kobayashi, Shigeru Oshima, Chiaki Maeyashiki, Yoichi Nibe, Kana Otsubo, Yu Matsuzawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development. Sci Rep. 2016.11; 6 36780. ( PubMed, DOI )

  10. Yu Matsuzawa, Shigeru Oshima, Yoichi Nibe, Masanori Kobayashi, Chiaki Maeyashiki, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62. Biochem Biophys Res Commun. 2015.01; 456 (1): 298-304. ( PubMed, DOI )

  11. Yu Matsuzawa, Shigeru Oshima, Masahiro Takahara, Chiaki Maeyashiki, Yasuhiro Nemoto, Masanori Kobayashi, Yoichi Nibe, Kengo Nozaki, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Averil Ma, Mamoru Watanabe. TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy. 2015; 11 (7): 1052-1062. ( PubMed, DOI )

  12. Masahiro Takahara, Yasuhiro Nemoto, Shigeru Oshima, Yu Matsuzawa, Takanori Kanai, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuhide Yamamoto, Mamoru Watanabe. IL-7 promotes long-term in vitro survival of unique long-lived memory subset generated from mucosal effector memory CD4+ T cells in chronic colitis mice. Immunol Lett. 2013; 156 (1-2): 82-93. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Yu Matsuzawa, Ken Cadwell. Examining the mechanism by which γδ T cells secret API5. The 52nd Annual Meeting of the Japanese Society for Immunology 2024.01.18 Makuhari, Japan

  2. Otsubo K, Maeyashiki C, Aonuma E, Matsuda H, Nibe Y, Kobayashi M, Matsuzawa Y, Watanabe M, Oshima S. Long-chain fatty acid regulates autophagy and polyubiquitination in intestinal epithelial cells. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.30 Tahoe(USA)

  3. Matsuda H, Nibe Y, Aonuma E, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Watanabe M, Oshima S. K33-linked polyubiquitin is recruited by SQSTM1/p62.. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.30 Tahoe(USA)

  4. Nibe Y, Matsuda H, Aonuma E, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Nakada S, Mamoru Watanabe M, Oshima S. Novel polyubiquitin imaging system, PolyUb-FC, visualized atypical polyubiquitin chain in living cells.. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.30 Tahoe(USA)

  5. Aonuma E, Nibe Y, Matsuda H, Otsubo K, Maeyashiki C, Kobayashi M, Matsuzawa Y, Watanabe M, Oshima S. Necroptosis stimulation regulates SQSTM1/p62-LC3 complex formation and polyubiquitination. Keystone Symposia - Ubiquitin Signaling (A8) 2018.01.29 Tahoe(USA)

  6. Kana Otsubo, Shigeru Oshima, Chiaki Maeyashiki, Emi Aonuma, Hiroki Matsuda, Masanori Kobayashi, Yoichi Nibe, Yu Matsuzawa, Mamoru Watanabe. HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells. The 8th International Symposium on Autophagy 2017.05.29 Nara Kasugano International Forum 甍 IRAKA(Japan)

  7. Yoichi Nibe, Shigeru Oshima, Emi Aonuma, Hiroki Matsuda, Kana Otsubo, Chiaki Maeyashiki, Masanori Kobayashi, Yu Matsuzawa, Shinichiro Nakada, Mamoru Watanabe. Novel polyubiquitin imaging reveals that atypical polyubiquitin contribute to autophagy via p62.. The 8th International Symposium on Autophagy 2017.05.29 Nara Kasugano International Forum 甍 IRAKA(Japan)

  8. Matsuzawa Y, Gomez L, Cadwell K. Autophagy protein ATG16L1 confers tolerance to a commensal virus by preventing cell death in the intestinal epithelium. DDW2017 2017.05.09 Chicago (USA)

  9. 大島　茂、前屋舗千明、仁部洋一、小林正典、松沢　優、鬼澤道夫、Averil Ma、渡辺　守. TNFAIP3 によるネクロプトーシス制御機構の解明. 第24回日本Cell Death学会学術集会 2015.07.11 大阪

  10. Matsuzawa Y, Oshima S, Ma Averil , Watanabe M. A Crohn's disease susceptibility gene A20 promotes autophagy by restricting mTOR in CD4 T cells.. GI Research Academy 2015 2015.06.12 東京

  11. Yu Matsuzawa, Shigeru Oshima, Masanori Kobayashi, Yoichi Nibe, Chiaki Maeyashiki, Averil I. Ma, Mamoru Watanabe. A Crohn's Disease Susceptibility Gene A20 Regulates Autophagy Dynamics in CD4 T Cells. DDW 2015 2015.05.17 Washington, D.C.

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Awards & Honors 【 display / non-display 】

  • 2019 Young Investigator Award，Crohn's & Colitis Congress，2019.01

  • Research Fellowship Award 2018，Crohn's & Colitis Foundation，2018.01

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Campus class subject 【 display / non-display 】

  • Physiological Laboratory Medicine (Ⅰ)，2023 - Now

  • Medical Genetics, Laboratory，2023 - Now

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