Personnel Information

写真a

NUMOTO Nobutaka


Job title

Assistant Professor

Birth date

1975

Graduating School 【 display / non-display

  • Kyoto University, Faculty of Science, 1999.03, Graduated

Graduate School 【 display / non-display

  • Kyoto University, Graduate School, Division of Natural Science, Master's Course, 2001.03, Completed

  • Kyoto University, Graduate School, Division of Natural Science, Doctor's Course, 2004.03, Accomplished credits for doctoral program

Degree 【 display / non-display

  • Ph.D., Kyoto University

Campus Career 【 display / non-display

  • 2012.10
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Advanced Molecular Medicine, Structural Biology, Assistant Professor
  • 2012.10
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Life Science and Technology, Life Science and Technology, Structural Biology, Assistant Professor

Research Areas 【 display / non-display

  • Structural biochemistry

 

Published Papers & Misc 【 display / non-display

  • Akihiro Nishiguchi, Nobutaka Numoto, Nobutoshi Ito, Takachika Azuma, Masayuki Oda. Three-dimensional structure of a high affinity anti-(4-hydroxy-3-nitrophenyl)acetyl antibody possessing a glycine residue at position 95 of the heavy chain. Mol. Immunol.. 2019.10; 114 545-552. ( PubMed, DOI )

  • Yuhi Hosoe, Nobutaka Numoto, Satomi Inaba, Shuhei Ogawa, Hisayuki Morii, Ryo Abe, Nobutoshi Ito, Masayuki Oda. Structural and functional properties of Grb2 SH2 dimer in CD28 binding. Biophys Physicobiol. 2019.02; 16 80-88. ( PubMed, DOI )

  • Yurina Miyashita, Nobutaka Numoto, Sundaram Arulmozhiraja, Shogo Nakano, Naoya Matsuo, Kanade Shimizu, Osamu Shibahara, Michiko Fujihara, Hiroki Kakuta, Sohei Ito, Teikichi Ikura, Nobutoshi Ito, Hiroaki Tokiwa. Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor α (RXRα). FEBS Lett.. 2019.01; 593 (2): 242-250. ( PubMed, DOI )

  • Numoto N, Kamiya N, Bekker GJ, Yamagami Y, Inaba S, Ishii K, Uchiyama S, Kawai F, Ito N, Oda M. Structural Dynamics of PET-degrading Cutinase-like Enzyme from Saccharomonospora viridis AHK190 in Substrate-bound States Elucidates Ca2+ Driven Catalytic Cycle. Biochemistry. 2018.09; 57 (36): 5289-5300. ( PubMed, DOI )

  • Rocio Otero, Michiyasu Ishizawa, Nobutaka Numoto, Teikichi Ikura, Nobutoshi Ito, Hiroaki Tokiwa, Antonio Mouriño, Makoto Makishima, Sachiko Yamada. 25 S-Adamantyl-23-yne-26,27-dinor-1α,25-dihydroxyvitamin D3: Synthesis, Tissue Selective Biological Activities, and X-ray Crystal Structural Analysis of Its Vitamin D Receptor Complex. J. Med. Chem.. 2018.08; 61 (15): 6658-6673. ( PubMed, DOI )

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Books etc 【 display / non-display

  • Nobutaka Numoto. Crystallography in Japan (II). Crystallographic Society of Japan, 2014.07 (ISBN : 978-4-9903861-2-2)

Conference Activities & Talks 【 display / non-display

  • Daisuke Imai, Nobutaka Numoto, Sundaram Arulmozhiraja, Shogo Masuda, Hiroki Kakuta, Hiroaki Tokiwa, Nobutoshi Ito. Structural analysis of NEt-3IB/NEt-4IB-bound Retinoid X Receptor α. 16th Conference of the Asian Crystallographic Association 2019.12.18 Singapore

  • Nobutaka Numoto, Yoshihiro Fukumori, Kunio Miki, Nobutoshi Ito. Allosteric structural change of giant hemoglobin. Annual Meeting 2019 and General Assembly of Crystallographic Society of Japan 2019.11.20 Kanazawa

  • Shotaro Yasukochi, Nobutaka Numoto, Kiminori Hori, Natsuko Tenno, Takeshi Tenno, Nobutoshi Ito, Hidekazu Hiroaki. Crystal structure of human Dishevelled1 PDZ with its inhibitor. The 57th Annual Meeting of the BSJ 2019.09.24 Miyazaki

  • Nobutaka Numoto, Yoshihiro Fukumori, Kunio Miki, Nobutoshi Ito. Time-resolved structure analysis of allosteric intermediate of the giant hemoglobin. The 57th Annual Meeting of the BSJ 2019.09.24 Miyazaki

  • Akihiro Nishiguchi, Nobutaka Numoto, Nobutoshi Ito, Takachika Azuma, Masayuki Oda. Antigen recognition mechanism of an affinity-matured single chain Fv antibody against anti-(4-hydroxy-3-nitrophenyl)acetyl. The 92nd Annual Meeting of the Japanese Biochemical Society 2019.09.18 Yokohama

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External class subject 【 display / non-display

  • ,Tokyo University of Agriculture and Technology