Personnel Information

写真a

TAKAHASHI Jun'Ichi


Job title

Assistant Professor
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Campus Career 【 display / non-display 】

  • 2017.04
    -
    2023.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Gastroenterology and Hepatology， Graduate Student
  • 2023.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Gastroenterology and Hepatology， Assistant Professor
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Published Papers & Misc 【 display / non-display 】

  1. Sho Anzai, Ami Kawamoto, Sayaka Nagata, Junichi Takahashi, Mao Kawai, Reiko Kuno, Sakurako Kobayashi, Satoshi Watanabe, Kohei Suzuki, Hiromichi Shimizu, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Shigeru Oshima, Mamoru Watanabe, Ryuichi Okamoto. TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells. Biochem. Biophys. Res. Commun.. 2020.04; 524 (3): 533-541. ( PubMed, DOI )

  2. Ryuichi Okamoto, Hiromichi Shimizu, Kohei Suzuki, Ami Kawamoto, Junichi Takahashi, Mao Kawai, Sayaka Nagata, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Mamoru Watanabe. Organoid-based regenerative medicine for inflammatory bowel disease. Regen Ther. 2020.03; 13 1-6. ( PubMed, DOI )

  3. Junichi Takahashi, Hady Yuki Sugihara, Shu Kato, Sayaka Nagata, Ryuichi Okamoto, Tomohiro Mizutani. Protocol to generate large human intestinal organoids using a rotating bioreactor. STAR Protocols. 2023.06; 4 (3): 102374. ( PubMed, DOI )

  4. Toshiaki Shibata, Daisuke Shinjo, Junichi Takahashi, Kiyohide Fushimi. Pandemic-resilient target setting in colorectal cancer screening for vulnerable older population. Cancer Medicine. 2023.01; 12 (1): 619-630. ( PubMed, DOI )

  5. Junichi Takahashi, Tomohiro Mizutani, Hady Yuki Sugihara, Sayaka Nagata, Shu Kato, Yui Hiraguri, Sayaka Takeoka, Mao Tsuchiya, Reiko Kuno, Sei Kakinuma, Mamoru Watanabe, Ryuichi Okamoto. Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoids. Cell Rep Methods. 2022.11; 2 (11): 100337. ( PubMed, DOI )

  6. Reiko Kuno, Go Ito, Ami Kawamoto, Yui Hiraguri, Hady Yuki Sugihara, Sayaka Takeoka, Sayaka Nagata, Junichi Takahashi, Mao Tsuchiya, Sho Anzai, Tomohiro Mizutani, Hiromichi Shimizu, Shiro Yui, Shigeru Oshima, Kiichiro Tsuchiya, Mamoru Watanabe, Ryuichi Okamoto. Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients. Biochem Biophys Rep. 2021.03; 25 100906. ( PubMed, DOI )

  7. Kohei Suzuki, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Toru Nakata, Satoru Fujii, Fumiaki Ishibashi, Ami Kawamoto, Sho Anzai, Reiko Kuno, Konomi Kuwabara, Junichi Takahashi, Minami Hama, Sayaka Nagata, Yui Hiraguri, Kento Takenaka, Shiro Yui, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto. Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties. J. Gastroenterol.. 2018.09; 53 (9): 1035-1047. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Junichi Takahashi, Tomohiro Mizutani, Ryuichi Okamoto. A suspension method for efficient induction and maturation of human intestinal organoids using a rotational bioreactor. 2023 RIKEN BDR-CuSTOM Joint Organoid Symposium 2023.02.17

  2. Junichi Takahashi, Tomohiro Mizutani, Ryuichi Okamoto. A suspension method for efficient induction and maturation of human intestinal organoids using a rotational bioreactor.. 2023 RIKEN BDR-CuSTOM Joint Organoid Symposium 2023.02.15

  3. Takahashi Junichi, Mizutani Tomohiro, Okamoto Ryuichi. A NOVEL SUSPENSION METHOD FOR EFFICIENT INDUCTION AND RAPID MATURATION OF HUMAN INTESTINAL ORGANOIDS USING A ROTATIONAL BIOREACTOR. DDW2022 2022.05

  4. Kawai M, Hama M, Nagata S, Kawamoto A, Suzuki K, Shimizu H, Anzai S, Takahashi J, Kuno R, Takeoka S, Hiraguri Y, Yui S, Okamoto R, Watanabe M. Functional analysis of isoflavones using patient-derived intestinal organoids. AOCC2019 2019.06.14 Taipei（Taiwan）

  5. Ryuichi Okamoto, Mao Kawai, Minami Hama, Sayaka Nagata, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Sho Anzai, Junichi Takahashi, Reiko Kuno, Sayaka Takeoka, Yui Hiraguri, Shiro Yui, Mamoru Watanabe. 【The 6th JSGE International Topic Conference　Lifestyle-related Diseases in Gastroenterology】Gastrointestinal tract（role of gut microbiome and diet）. 第105回 日本消化器病学会総会 2019.05.10 ホテル日航金沢（石川県金沢市）

  6. Ishibashi F, Kuwabara K, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Ectopic expression of reg3a in the mice distal Colon is mediated by interactions between notch and Il-22 signaling pathways, and promotes tissue repair By the augmentation of EGFR signaling. UEGW 2018 2018.10.22 Vienna（Austria）

  7. Kuwabara K, Ishibashi F, Kawamoto A, Anzai S, Takahashi J, Nagata S, Shimizu H, Yui S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Long-lived secretory cells residing in the Mouse proximal colon serve as reserve stem cells Under DNA damage-induced mucosal injury. UEGW 2018 2018.10.22 Vienna（Austria）

  8. Suzuki K, Takahashi J, Hiraguri Y, Yui S, Shimizu H, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M. . Crohn’s disease patient-derived small intestinal organoids reveal diseasestatus related modification of stem cell properties.. 5th TERMIS World Congress 2018 2018.09.07 Kyoto（JAPAN）

  9. Suzuki K, Murano T, Hiraguri Y, Takahashi J, Shimizu H,Anzai S, Kuwabara K, Kawamoto A, Ishibashi F, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Watanabe M, Okamoto R... Crohn’s disease patient-derived small intestinal organoids reveal disease-status related modification of stem cell properties.. 5th TERMIS World Congress 2018 2018.09.06 Kyoto（JAPAN）

  10. Ishibashi F, Shimizu H, Kawamoto A, Suzuki K, Anzai S, Kuwabara K, Takahashi J, Nagata S, Oshima S, Tsuchiya K, Nakamura T, Watanabe M, Okamoto R. Mouse colonic secretory cells de-differentiate into intestinal stem cells and promote mucosal repair through activation of NF-KB signalin. ISSCR2018 2018.06.20 Melbourne

  11. Suzuki K, Kuwabara K, Takahashi J, Anzai S, Kuno R, Kawamoto A, Ishibashi F, Nagata S, Hiraguri Y, Yui S, Tsuchiya K, Nakamura T, Ohtsuka K, Okamoto R, Watanabe M.. Single-cell level analysis of organoids derived from CD patients reveals disease-status related modifications of small intestinal stem cells. DDW2018 2018.06.04 Washington D.C (USA）

  12. A. Kawamoto G. Ito T. Nakata S. Fujii K. Suzuki F. Ishibashi H. Shimizu S. Nagata S. Anzai R. Kuno K. Kuwabara M. Kawai J. Takahashi M. Hama K. Tsuchiya T. Nakamura R. Okamoto M. Watanabe. The ubiquitin-like protein ubiquitin d is up-regulated by synergy of notch and pro-inflammatory cytokines in the inflamed intestinal epithelia of ibd patients.. UEGW2017 (欧州消化器病学会週間2017） 2017.11.01 Barcelona(Spain)

  13. F. Ishibashi H. Shimizu A. Kawamoto G. Ito T. Nakata S. Fujii K. Suzuki R. Kuno S. Anzai K. Kuwabara M. Kawai J. Takahashi M. Hama S. Nagata K. Tsuchiya T. Nakamura R. Okamoto M. Watanabe. Reprogrammed Atoh1+ intestinal epithelial cells contribute to regenerate damaged colonic mucosa in DSS-induced colitis. UEGW2017 (欧州消化器病学会週間2017） 2017.11.01 Barcelona(Spain)

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Others 【 display / non-display 】

  • The future of replacement organs is (quite possibly) here: robust human intestinal organoids created in a lab，2022.12

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