論文・総説 - 桑原　宏哉

1. Su Su Lei Mon, Kotaro Yoshioka, Chunyan Jia, Taiki Kunieda, Yutaro Asami, Kie Yoshida-Tanaka, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Tetsuya Nagata, Takanori Yokota. Highly efficient gene silencing in mouse brain by overhanging-duplex oligonucleotides via intraventricular route. FEBS Lett. 2020.05; 594 (9): 1413-1423. ( PubMed, DOI )

2. Masaki Ohyagi, Takashi Irioka, Takuya Ohkubo, Satoru Ishibashi, Yuko K Takahashi, Eiichiro Amano, Akira Machida, Hiroya Kuwahara, Takanori Yokota. Intrathecal IgG Synthesis and Persistent Inflammation Are Associated with White Matter Lesions in HIV-negative Patients with Cryptococcal Meningoencephalitis. Intern Med. 2019.11; 58 (21): 3077-3082. ( PubMed, DOI )

3. Kotaro Yoshioka, Taiki Kunieda, Yutaro Asami, Huijia Guo, Haruka Miyata, Kie Yoshida-Tanaka, Yumiko Sujino, Wenying Piao, Hiroya Kuwahara, Kazutaka Nishina, Rintaro Iwata Hara, Tetsuya Nagata, Takeshi Wada, Satoshi Obika, Takanori Yokota. Highly efficient silencing of microRNA by heteroduplex oligonucleotides. Nucleic Acids Res. 2019.08; 47 (14): 7321-7332. ( PubMed, DOI )

4. Satoshi Zeniya, Hiroya Kuwahara, Kaiichi Daizo, Akihiro Watari, Masuo Kondoh, Kie Yoshida-Tanaka, Hidetoshi Kaburagi, Ken Asada, Tetsuya Nagata, Masahiro Nagahama, Kiyohito Yagi, Takanori Yokota. Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system. J Control Release. 2018.05; 283 126-134. ( PubMed, DOI )

5. Hiroya Kuwahara, Jindong Song, Takahiro Shimoura, Kie Yoshida-Tanaka, Tadahaya Mizuno, Tatsuki Mochizuki, Satoshi Zeniya, Fuying Li, Kazutaka Nishina, Tetsuya Nagata, Shingo Ito, Hiroyuki Kusuhara, Takanori Yokota. Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo. Sci Rep. 2018.03; 8 (1): 4377. ( PubMed, DOI )

6. Y Anraku, H Kuwahara, Y Fukusato, A Mizoguchi, T Ishii, K Nitta, Y Matsumoto, K Toh, K Miyata, S Uchida, K Nishina, K Osada, K Itaka, N Nishiyama, H Mizusawa, T Yamasoba, T Yokota, K Kataoka. Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain. Nat Commun. 2017.10; 8 (1): 1001. ( PubMed, DOI )

7. Koya Ono, Ken Murata, Toshinari Arai, Tomoyuki Kino, Keisuke Onaka, Satoru Takahashi, Hirotaka Sato, Hiroya Kuwahara. Posterior reversible encephalopathy syndrome after iron administration in a patient with chronic severe anemia. Journal of the Neurological Sciences. 2016.08; 367 333-334. ( PubMed, DOI )

8. Masahiro Murakami, Kazutaka Nishina, Chie Watanabe, Kie Yoshida-Tanaka, Wenying Piao, Hiroya Kuwahara, Yuji Horikiri, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka, Masayuki Yoshida, Hidehiro Mizusawa, Takanori Yokota.. Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route. Scientific Reports. 2015.11; 5 17035. ( PubMed, DOI )

9. Kazutaka Nishina, Wenying Piao, Kie Yoshida-Tanaka, Yumiko Sujino, Tomoko Nishina, Tsuyoshi Yamamoto, Keiko Nitta, Kotaro Yoshioka, Hiroya Kuwahara, Hidenori Yasuhara, Takeshi Baba, Fumiko Ono, Kanjiro Miyata, Koichi Miyake, Punit P Seth, Audrey Low, Masayuki Yoshida, C Frank Bennett, Kazunori Kataoka, Hidehiro Mizusawa, Satoshi Obika, Takanori Yokota.. DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing. Nature Communications.. 2015.08; 6 7969. ( PubMed, DOI )

10. Hiroya Kuwahara, Kazutaka Nishina, Takanori Yokota.. Blood-brain barrier: a novel therapeutic target in multiple sclerosis. Clinical and Experimental Neuroimmunology.. 2015.05; 6 (2): 129-138. ( DOI )

11. Tomoko Nishina, Junna Numata, Kazutaka Nishina, Kie Yoshida-Tanaka, Keiko Nitta, Wenying Piao, Rintaro Iwata, Shingo Ito, Hiroya Kuwahara, Takeshi Wada, Hidehiro Mizusawa, Takanori Yokota.. Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol. Mol Ther Nucleic Acids.. 2015.01; 4 e220. ( PubMed, DOI )

12. Kuwahara Hiroya, Tsuchiya Kuniaki, Kobayashi Zen, Inaba Akira, Akiyama Haruhiko, Mizusawa Hidehiro.. Cryptococcal meningitis accompanying lymphocytic inflammation predominantly in cerebral deep white matter: a possible manifestation of immune reconstitution inflammatory syndrome. Neuropathology.. 2014.02; 34 (1): 45-48. ( PubMed, DOI )

13. Hirai Takashi, Enomoto Mitsuhiro, Kaburagi Hidetoshi, Sotome Shinichi, Yoshida-Tanaka Kie, Ukegawa Madoka, Kuwahara Hiroya, Yamamoto Mariko, Tajiri Mio, Miyata Haruka, Hirai Yukihiko, Tominaga Makoto, Shinomiya Kenichi, Mizusawa Hidehiro, Okawa Atsushi, Yokota Takanori.. Intrathecal AAV serotype 9-mediated delivery of shRNA against TRPV1 attenuates thermal hyperalgesia in a mouse model of peripheral nerve injury. Molecular Therapy.. 2014.02; 22 (2): 409-419. ( PubMed, DOI )

14. Kuwahara Hiroya, Suzuki Shigeharu, Matsumura Ken, Watanabe Mutsufusa, Yakushiji Fumiatsu, Fujigasaki Hiroto.. Ocular flutter, generalized myoclonus, and truncal ataxia in a patient with Graves' ophthalmopathy. Journal of Neurology.. 2013.11; 260 (11): 2906-2907. ( PubMed, DOI )

15. Machida Akira, Kuwahara Hiroya, Mayra Azat, Kubodera Takayuki, Hirai Takashi, Sunaga Fumiko, Tajiri Mio, Hirai Yukihiko, Shimada Takashi, Mizusawa Hidehiro, Yokota Takanori.. Intraperitoneal administration of AAV9-shRNA inhibits target gene expression in the dorsal root ganglia of neonatal mice. Molecular Pain.. 2013.07; 9 36. ( PubMed, DOI )

16. Hiroya Kuwahara.. Persistent hemichorea. New England Journal of Medicine. 2013.05; 368 (20): e26. ( PubMed, DOI )

17. Piao Wenying, Nishina Kazutaka, Yoshida-Tanaka Kie, Kuwahara Hiroya, Nishina Tomoko, Sakata Mina, Mizusawa Hidehiro, Yokota Takanori. Efficient in vivo delivery of antisense oligonucleotide to choroid plexus. J Med Dent Sci. 2013.03; 60 (1): 9-16. ( PubMed )

18. Kuwahara Hiroya, Matsumura Ken, Watanabe Mutsufusa, Fujigasaki Hiroto. Intravenous t-PA for the occlusion of an accessory MCA. Intern Med. 2013.01; 52 (1): 163. ( PubMed )

19. Hirai Takashi, Enomoto Mitsuhiro, Machida Akira, Yamamoto Mariko, Kuwahara Hiroya, Tajiri Mio, Hirai Yukihiko, Sotome Shinichi, Mizusawa Hidehiro, Shinomiya Kenichi, Okawa Atsushi, Yokota Takanori. Intrathecal shRNA-AAV9 inhibits target protein expression in the spinal cord and dorsal root ganglia of adult mice. Hum Gene Ther Methods. 2012.04; 23 (2): 119-127. ( PubMed, DOI )

20. Kuwahara Hiroya, Yokota Takanori. Delivery of siRNA into the blood-brain barrier: recent advances and future perspective. Ther Deliv. 2012.04; 3 (4): 417-420. ( PubMed )