Personnel Information

写真a

HOMMA Hidenori


Job title

Associate Professor

Mail Address

The inquiry by e-mail is 《here

Field Introduction URL

https://www.tmd.ac.jp/english/npat/

Graduating School 【 display / non-display

  • University of Tsukuba, Third Cluster of College, 2004.03, Graduated

Graduate School 【 display / non-display

  • University of Tsukuba, Doctor's Course, 2009.03, Completed

Campus Career 【 display / non-display

  • 2013.04
    -
    2021.05
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Neuropathology, Project Assistant Professor
  • 2021.06
    -
    2022.03
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Neuropathology, Project Junior Associate Professor
  • 2022.05
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, a, Department of Neuropathology, Associate Professor

External Career 【 display / non-display

  • 2009.04
    -
    2011.03
    National Institute of Information and Communications Technology,
  • 2011.04
    -
    2012
    Mie University, Visiting Lecturer
  • 2011.04
    -
    2012.07
    Mie University,
  • 2012.08
    -
    2013.03
    Mie University, Project Assistant Professor

Academic Society Affiliations 【 display / non-display

  • The Institute of Electronics, Information and Communication Engineers

  • Information Processing Society of Japan

 

Published Papers & Misc 【 display / non-display

  1. Jin Meihua, Shiwaku Hiroki, Tanaka Hikari, Obita Takayuki, Ohuchi Sakurako, Yoshioka Yuki, Jin Xiaocen, Kondo Kanoh, Fujita Kyota, Homma Hidenori, Nakajima Kazuyuki, Mizuguchi Mineyuki, Okazawa Hitoshi. Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation NATURE COMMUNICATIONS. 2021.11; 12 (1): ( DOI )

  2. Tanaka Hikari, Kondo Kanoh, Fujita Kyota, Homma Hidenori, Tagawa Kazuhiko, Jin Xiaocen, Jin Meihua, Yoshioka Yuki, Takayama Sumire, Masuda Hitomi, Tokuyama Rie, Nakazaki Yukoh, Saito Takashi, Saido Takaomi, Murayama Shigeo, Ikura Teikichi, Ito Nobutoshi, Yamamori Yu, Tomii Kentaro, Bianchi Marco E., Okazawa Hitoshi. HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology COMMUNICATIONS BIOLOGY. 2021.10; 4 (1): ( DOI )

  3. Jin Meihua, Jin Xiaocen, Homma Hidenori, Fujita Kyota, Tanaka Hikari, Murayama Shigeo, Akatsu Hiroyasu, Tagawa Kazuhiko, Okazawa Hitoshi. Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis COMMUNICATIONS BIOLOGY. 2021.08; 4 (1): ( DOI )

  4. Kanoh Kondo, Teikichi Ikura, Hikari Tanaka, Kyota Fujita, Sumire Takayama, Yuki Yoshioka, Kazuhiko Tagawa, Hidenori Homma, Su Liu, Ryosuke Kawasaki, Yong Huang, Nobutoshi Ito, Shin-Ichi Tate, Hitoshi Okazawa. Hepta-Histidine Inhibits Tau Aggregation. ACS Chem Neurosci. 2021.07; 12 (16): 3015-3027. ( PubMed, DOI )

  5. Hidenori Homma, Hikari Tanaka, Meihua Jin, Xiaocen Jin, Yong Huang, Yuki Yoshioka, Christian Jf Bertens, Kohei Tsumaki, Kanoh Kondo, Hiroki Shiwaku, Kazuhiko Tagawa, Hiroyasu Akatsu, Naoki Atsuta, Masahisa Katsuno, Katsutoshi Furukawa, Aiko Ishiki, Masaaki Waragai, Gaku Ohtomo, Atsushi Iwata, Takanori Yokota, Haruhisa Inoue, Hiroyuki Arai, Gen Sobue, Masaki Sone, Kyota Fujita, Hitoshi Okazawa. DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis. Life Sci Alliance. 2021.06; 4 (7): ( PubMed, DOI )

  6. Tanaka Hikari, Homma Hidenori, Fujita Kyota, Kondo Kanoh, Yamada Shingo, Jin Xiaocen, Waragai Masaaki, Ohtomo Gaku, Iwata Atsushi, Tagawa Kazuhiko, Atsuta Naoki, Katsuno Masahisa, Tomita Naoki, Furukawa Katsutoshi, Saito Yuko, Saito Takashi, Ichise Ayaka, Shibata Shinsuke, Arai Hiroyuki, Saido Takaomi, Sudol Marius, Muramatsu Shin-ichi, Okano Hideyuki, Mufson Elliott J., Sobue Gen, Murayama Shigeo, Okazawa Hitoshi. YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology NATURE COMMUNICATIONS. 2020.01; 11 (1): ( DOI )

  7. Fujita Kyota, Chen Xigui, Homma Hidenori, Tagawa Kazuhiko, Okazawa Hitoshi. Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology(和訳中) 臨床神経学. 2019.11; 59 (Suppl.): S213. ( ichushi )

  8. Fujita Kyota, Mao Ying, Uchida Shigenori, Chen Xigui, Shiwaku Hiroki, Tamura Takuya, Ito Hikaru, Homma Hidenori, Tagawa Kazuhiko, Okazawa Hitoshi. Developmental YAPdeltaC determines adult pathology in a mouse model of spinocerebellar ataxia type 1(和訳中) 臨床神経学. 2018.12; 58 (Suppl.): S200. ( ichushi )

  9. Tanaka Hikari, Kondo Kanoh, Chen Xigui, Homma Hidenori, Tagawa Kazuhiko, Kerever Aurelian, Aoki Shigeki, Saito Takashi, Saido Takaomi, Muramatsu Shin-ichi, Fujita Kyota, Okazawa Hitoshi. The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology MOLECULAR PSYCHIATRY. 2018.10; 23 (10): 2090-2110. ( PubMed, DOI )

  10. Fujita K, Homma H, Kondo K, Ikuno M, Yamakado H, Tagawa K, Murayama S, Takahashi R, Okazawa H. Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology. eNeuro. 2018.07; 5 (4): ( PubMed, DOI )

  11. Kyota Fujita, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Mutsuki Amano, Ayumu Saito, Seiya Imoto, Hiroyasu Akatsu, Yoshio Hashizume, Kozo Kaibuchi, Satoru Miyano, Hitoshi Okazawa. Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. Nat Commun. 2018.01; 9 (1): 433. ( PubMed, DOI )

  12. Kyota Fujita, Ying Mao, Shigenori Uchida, Xigui Chen, Hiroki Shiwaku, Takuya Tamura, Hikaru Ito, Kei Watase, Hidenori Homma, Kazuhiko Tagawa, Marius Sudol, Hitoshi Okazawa. Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1. Nat Commun. 2017.11; 8 (1): 1864. ( PubMed, DOI )

  13. Fujita K., Motoki K., Tagawa K., Chen X., Hama H., Nakajima K., Homma H., Tamura T., Miyawaki A., Okazawa H.. HMGB1 triggers neurite degeneration via TLR4-MARCKS, and is a potential therapeutic target for alzheimer's disease JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 64-65. ( DOI )

  14. Chen X., Mao Y., Xu M., Fujita K., Motoki K., Sasabe T., Homma H., Tagawa K., Tamura T., Okazawa H.. Targeting tead/yap-transcription-dependent necrosis, triad, ameliorates Huntington's disease pathology JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017.10; 381 219. ( DOI )

  15. Mao Y, Chen X, Xu M, Fujita K, Motoki K, Sasabe T, Homma H, Murata M, Tagawa K, Tamura T, Kaye J, Finkbeiner S, Blandino G, Sudol M, Okazawa H. Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology. Human molecular genetics. 2016.11; 25 (21): 4749-4770. ( PubMed, DOI )

  16. Imamura, T., Fujita, K., Tagawa, K., Ikura, T., Chen, X., Homma, H., Tamura, T., Mao, Y., Taniguchi, JB., Motoki, K., Nakabayashi, M., Ito, N., Yamada, K., Tomii, K., Okano, H., Kaye, J., Finkbeiner, S., Okazawa, H.. Identification of hepta-histidine as a candidate drug for Huntington’s disease by in silico-in vitro-in vivo-integrated screens of chemical libraries. Scientific Reports.. 2016.09; 6 33861.

  17. Imamura T, Fujita K, Tagawa K, Ikura T, Chen X, Homma H, Tamura T, Mao Y, Taniguchi JB, Motoki K, Nakabayashi M, Ito N, Yamada K, Tomii K, Okano H, Kaye J, Finkbeiner S, Okazawa H. Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Scientific reports. 2016.09; 6 33861. ( PubMed, DOI )

  18. Taniguchi, JB., Kondo, K., Fujita, K., Chen, X., Homma, H., Sudo, T., Mao, Y., Watase, K., Tanaka, T., Tagawa, K., Tamura, T., Muramatsu, SI., Okazawa, H.. RpA1 ameliorates symptoms of mutant Ataxin-1 knock-in mice and enhances DNA damage repair. Hum. Mol. Genet.. 2016.08; ( PubMed, DOI )

  19. Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, Homma H, Tamura T, Watanabe H, Katsuno M, Matsumi C, Kajikawa M, Saito T, Saido T, Sobue G, Miyawaki A, Okazawa H. HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. Scientific reports. 2016.08; 6 31895. ( PubMed, DOI )

  20. Mao, Y., Tamura, T., Yuki, Y., Abe, D., Tamada, Y., Imoto, S., Tanaka, H., Homma, H., Tagawa, K., Miyano, S., and Okazawa, H. The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing. Cell Death & Disease. 2016.04; 7 e2207. ( PubMed, DOI )

  21. Chen, X., Kondo, k., Motoki, k., Homma, H., Okazawa, H.. Fasting activates macroautophagy in neurons of Alzheimer’s disease mouse model but is insufficient to degrade amyloid-beta Scientific Reports. 2015.07; (12115 (2015)): ( DOI )

  22. Hikaru Ito, Kyota Fujita, Kazuhiko Tagawa, Xigui Chen, Hidenori Homma, Toshikazu Sasabe, Jun Shimizu, Shigeomi Shimizu, Takuya Tamura, Shin-ichi Muramatsu, Hitoshi Okazawa. HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice. EMBO Mol Med. 2015.01; 7 (1): 78-101. ( PubMed, DOI )

  23. Tagawa, K., Homma, H., Saito, A., Fujita, K., Chen, X., Imoto, S., Oka, T., Ito, H., Motoki, K., Yoshida, C., Hatsuta, H., Murayama, S., Iwatsubo, T., Miyano, S., Okazawa, H.. Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain. Hum Mol Genet. 2014.09; ( PubMed, DOI )

  24. Ito, H., Shiwaku, H., Yoshida, C., Homma, H., Luo, H., Chen, X., Fujita, K., Musante, L., Fischer, U., Frints, S G M., Romano, C., Ikeuchi, Y., Shimamura, T., Imoto, S., Miyano, S., Muramatsu, S-I., Kawauchi, T., Hoshino, M., Sudol, M., Arumughan, A., Wanker, E E., Rich, T., Schwartz, C., Matsuzaki, F., Bonni, A., Kalscheuer, V M., Okazawa, H.. In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells. Mol Psychiatry. 2014.07; ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Tanaka Hikari, Kondo Kanoh, Chen Xigui, Homma Hidenori, Tagawa Kazuhiko, Saido Takaomi, Muramatsu Shin-ichi, Fujita Kyota, Okazawa Hitoshi. 超早期アルツハイマー病においてSRRM2リン酸化はシナプス病理を誘発する(Phosphorylation of SRRM2 leads to synaptic pathology at ultra-early phase of Alzheimer's disease). 臨床神経学 2020.11.01

  2. Fujita Kyota, Chen Xigui, Homma Hidenori, Tagawa Kazuhiko, Okazawa Hitoshi. Tyro3を治療標的とすることでタウを介したシナプス病理によりPGRN変異体FTLD-TDPモデルに改善を認めた(Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology). 臨床神経学 2019.11.01

  3. Hikari Tanaka, Kanoh Kondo, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Aurelian Kerever, Shigeki Aoki, Takashi Saito, Takaomi Saido, Shin-ichi Muramatsu, Kyota Fujita, Hitoshi Okazawa. The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology. NEURO2019 2019.07.27 Toki Messe(Niigata)

  4. Kyota Fujita, Xigui Chen, Hidenori Homma, Kazuhiko Tagawa, Hitoshi Okazawa. Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. 60th annual meeting of the japanese society of neurology 2019.05.22 Osaka International Convention Center(Osaka)

  5. Fujita Kyota, Mao Ying, Uchida Shigenori, Chen Xigui, Shiwaku Hiroki, Tamura Takuya, Ito Hikaru, Homma Hidenori, Tagawa Kazuhiko, Okazawa Hitoshi. 発達期のYAPdeltaCは脊髄小脳失調症1型モデルマウスにおける成体の病理を決定する(Developmental YAPdeltaC determines adult pathology in a mouse model of spinocerebellar ataxia type 1). 臨床神経学 2018.12.01

  6. 2. 藤田 慶大、Ying Mao、陳 西貴、山西 恵美子、本間 秀典、田川 一彦、岡澤 均. ハンチントン病における新規ネクローシスTRIADの分子病態. 第41回日本神経科学大会 2018.07.28

  7. 3. Kazuhiko Tagawa, Kyota Fujita Ying Mao, Shigenori Uchida, Xigui Chen, Kei Watase, Hidenori Homma, Marius Sudol, Hitoshi Okazawa. Developmental YAPdeltaC determines adult pathology in a model of spinocerebellar ataxia type 1. 第41回日本神経科学大会 2018.07.28

  8. 4. Hikari Tanaka, Ying Mao, Takuya Tamura, Yoshie Yuki, Daisu Abe, Hidenori Homma, Kazuhiko Tagawa, Hitoshi Okazawa. The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing. 第41回日本神経科学大会 2018.07.28

  9. 5. Kanoh Kondo, Xigui Chen, Kazumi Motoki, Hidenori Homma, Hitoshi Okazawa. In vivo imaging of intracellular organelle in neurons of Alzheimer's disease and other neurodegenerative disease model.. 第41回日本神経科学大会 2018.07.27

  10. 6. 藤田 慶大、毛 瀅、内田 成則、陳 西貴、塩飽 裕紀、田村 拓也、伊藤 日加瑠、本間 秀典、田川 一彦、岡澤 均. Developmental YAPdeltaC determines adult pathology in a mouse model of spinocerebellarataxia type 1.. 第59回日本神経学会学術大会 2018.05.23

  11. Juliana Bosso Taniguchi, Kanoh Kondo, Kyota Fujita, Xigui Chen, Hidenori Homma , Ying Mao , Kazuhiko Tagawa , Hitoshi Okazawa.. RPA1 AMELIORATES SYMPTOMS OF MUTANT ATAXIN-1 KNOCK-IN MICE AND ENHANCE DNA DAMAGE REPAIR. XXIII World Congress of Neurology (WCN 2017) 合同開催:第58回日本神経学会学術大会・第23回世界神経学会議 2017.09.17 Kyoto International Conference Center (日本、京都)

  12. Kyota Fujita, Kazumi Motoki, Kazuhiko Tagawa, Xigui Chen, Hiroshi Hama, Kazuyuki Nakajima, Hidenori Homma, Takuya Tamura, Atsushi Miyawaki, Hitoshi Okazawa.. HMGB1 TRIGGERS NEURITE DEGENERATION VIA TLR4-MARCKS, AND IS A POTENTIAL THERAPEUTIC TARGET FOR ALZHEIMER’S DISEASE. XXIII World Congress of Neurology (WCN 2017) 合同開催:第58回日本神経学会学術大会・第23回世界神経学会議 2017.09.17 Kyoto International Conference Center (日本、京都)

  13. 7. Juliana Bosso Taniguchi, Kanoh Kondo, Kyota Fujita, Xigui Chen, Hidenori Homma, Ying Mao, Kazuhiko Tagawa, Hitoshi Okazawa. “RPA1 AMELIORATES SYMPTOMS OF MUTANT ATAXIN-1 KNOCK-IN MICE AND ENHANCE DNA DAMAGE REPAIR. RPA1 AMELIORATES SYMPTOMS OF MUTANT ATAXIN-1 KNOCK-IN MICE AND ENHANCE DNA DAMAGE REPAIR. XXIII World Congress of Neurology (WCN 2017) 合同開催:第58回日本神経学会学術大会・第23回世界神経学会議 2017.09.17

  14. Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology. 9. Mao Ying, Xigui Chen, Xu Min, Kyota Fujita, Kazumi Motoki, Toshikazu Sasabe, Hidenori Homma, Miho Murata, Kazuhiko Tagawa, Takuya Tamura, Kaye Julia, Steven Finkbeiner, Giovanni Blandino, Marius Sudol, Kanoh Kondo, Hitoshi Okazawa. XXIII World Congress of Neurology (WCN 2017) 合同開催:第58回日本神経学会学術大会・第23回世界神経学会議 2017.09.17

  15. 8. Kyota Fujita, Kazumi Motoki, Kazuhiko Tagawa, Xigui Chen, Hiroshi Hama, Kazuyuki Nakajima, Hidenori Homma, Takuya Tamura, Atsushi Miyawaki, Hitoshi Okazawa. HMGB1 TRIGGERS NEURITE DEGENERATION VIA TLR4-MARCKS, AND IS A POTENTIAL THERAPEUTIC TARGET FOR ALZHEIMER’S DISEASE.. XXIII World Congress of Neurology (WCN 2017) 合同開催:第58回日本神経学会学術大会・第23回世界神経学会議 2017.09.17

  16. Xigui Chen, Mao Ying, Xu Min, Kyota Fujita, Kazumi Motoki, Toshikazu Sasabe, Hidenori Homma, Miho Murata, Kazuhiko Tagawa, Takuya Tamura, Kaye Julia, Steven Finkbeiner, Giovanni Blandino, Marius Sudol, Kanoh Kondo, Hitoshi Okazawa.. Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology. 第40回日本神経科学大会 2017.07.22 Kyoto International Conference Center (日本、京都)

  17. 10. Mao Ying, Xigui Chen, Xu Min, Kyota Fujita, Kazumi Motoki, Toshikazu Sasabe, Hidenori Homma, Miho Murata, Kazuhiko Tagawa, Takuya Tamura, Kaye Julia, Steven Finkbeiner, Giovanni Blandino, Marius Sudol, Kanoh Kondo, Hitoshi Okazawa. Targeting TEAD/YAP-transcription-dependent necrosis, TRIAD, ameliorates Huntington's disease pathology. 第40回日本神経科学大会 2017.07.22

  18. Juliana Bosso Taniguchi, Kanoh Kondo, Kyota Fujita, Chen Xigui, Hidenori Homma, Takeaki Sudo,Ying Mao, Kei Watase, Toshihiro Tanaka, Kazuhiko Tagawa, Takuya Tamura, Shin-Ichi Muramatsu, Hitoshi Okazawa.. RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair. 第40回日本神経科学大会 2017.07.20 幕張メッセ(幕張市)

  19. Kyota Fujita, Kazumi Motoki, Kazuhiko Tagawa, Xigui Chen, Hiroshi Hama, Kazuyuki Nakajima, Hidenori Homma, Takuya Tamura, Masahisa Katsuno, Takashi Saito, Takaomi Saido, Gen Sobue, Atsushi Miyawaki, Hitoshi Okazawa. . HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. 第40回日本神経科学大会 2017.07.20 幕張メッセ(幕張市)

  20. 11. Kyota Fujita, Kazumi Motoki, Kazuhiko Tagawa, Xigui Chen, Hiroshi Hama, Kazuyuki Nakajima, Hidenori Homma, Takuya Tamura, Masahisa Katsuno, Takashi Saito, Takaomi Saido, Gen Sobue, Atsushi Miyawaki, Hitoshi Okazawa. HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. 第40回日本神経科学大会 2017.07.20

  21. 12. Juliana Bosso Taniguchi, Kanoh Kondo, Kyota Fujita, Chen Xigui, Hidenori Homma, Takeaki Sudo,Ying Mao, Kei Watase, Toshihiro Tanaka, Kazuhiko Tagawa, Takuya Tamura, Shin-Ichi Muramatsu, Hitoshi Okazawa. RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair. 2017.07.20

  22. 13. Xigui Chen, Kanoh Kondo, Kazumi Motoki, Hidenori Homma, Hitoshi Okazawa. Fasting activates macroautophagy in neurons of Alzheimer’s disease mice but is insufficient to degrade amyloid-beta. 2016.07.21

  23. 14. Ying Mao, Takuya Tamura, Yoshie Yuki, Daisu Abe, Yoshinori Tamada, Seiya Imoto, Hikari Tanaka, Hidenori Homma, Kazuhiko Tagawa, Satoru Miyano, Hitoshi Okazawa. The hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing. 第39回日本神経科学大会 2016.07.20

  24. Xigui Chen, Kanoh Kondo, Kazumi Motoki, Hidenori Homma, Hitoshi Okazawa. Fasting activates macroautophagy in neurons of AD mice but is insufficient to degrade amyloid-beta. 第57回日本神経学会学術大会 2016.05.19 神戸国際展示場(兵庫県神戸市)

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