Personnel Information

写真a

YUI Naofumi


Job title

Visiting Lecturer

Research Areas, Keywords

nephrology, cell biology

Graduating School 【 display / non-display

  • Gunma University, Faculty of Medicine, 2000.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Graduate School, Division of Medical Sciences, Doctor's Course, 2010.03, Completed

Campus Career 【 display / non-display

  • 1900.01
    -
    2016.02
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Nephrology, Associate Professor
  • 2015.04
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Nephrology, Visiting Lecturer
  • 2016.05
    -
    2017.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Nephrology, Visiting Lecturer
  • 2017.05
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Nephrology, Visiting Lecturer
  • 2018.05
    -
    2019.04
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, -, -, Visiting Lecturer
  • 2019.05
    -
    2020.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, -, -, Visiting Lecturer
  • 2020.05
    -
    2021.04
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, -, -, Visiting Lecturer
  • 2021.05
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, -, -, Visiting Lecturer

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Research Areas 【 display / non-display

  • Nephrology

Qualification Acquired 【 display / non-display

  • Doctor

 

Published Papers & Misc 【 display / non-display

  1. Bouley R, Yui N, Terlouw A, Cheung PW, Brown D. Chlorpromazine Induces Basolateral Aquaporin-2 Accumulation via F-Actin Depolymerization and Blockade of Endocytosis in Renal Epithelial Cells. Cells. 2020.04; 9 (4): ( PubMed, DOI )

  2. Ando F, Mori S, Yui N, Morimoto T, Nomura N, Sohara E, Rai T, Sasaki S, Kondo Y, Kagechika H, Uchida S. AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus. Nature communications. 2018.04; 9 (1): 1411. ( PubMed, DOI )

  3. Zeniya M, Mori T, Yui N, Nomura N, Mandai S, Isobe K, Chiga M, Sohara E, Rai T, Uchida S. The proteasome inhibitor bortezomib attenuates renal fibrosis in mice via the suppression of TGF-β1. Scientific reports. 2017.10; 7 (1): 13086. ( PubMed, DOI )

  4. Li W, Jin WW, Tsuji K, Chen Y, Nomura N, Su L, Yui N, Arthur J, Cotecchia S, Paunescu TG, Brown D, Lu HAJ. Ezrin directly interacts with AQP2 and promotes its endocytosis. Journal of cell science. 2017.09; 130 (17): 2914-2925. ( PubMed, DOI )

  5. Yui N, Ando F, Sasaki S, Uchida S. Ser-261 phospho-regulation is involved in pS256 and pS269-mediated aquaporin-2 apical translocation. Biochemical and biophysical research communications. 2017.08; 490 (3): 1039-1044. ( PubMed, DOI )

  6. Yui N, Sasaki S, Uchida S. Aquaporin-2 Ser-261 phosphorylation is regulated in combination with Ser-256 and Ser-269 phosphorylation. Biochemical and biophysical research communications. 2017.01; 482 (4): 524-529. ( PubMed, DOI )

  7. Ando F, Sohara E, Morimoto T, Yui N, Nomura N, Kikuchi E, Takahashi D, Mori T, Vandewalle A, Rai T, Sasaki S, Kondo Y, Uchida S. Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway. Nature communications. 2016.11; 7 13636. ( PubMed, DOI )

  8. Yamaguchi Wakaba, Yui Naofumi, Nagao Toshikage, Oshikawa Gaku, Negi Mariko, Iimori Soichiro, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi. 長期ボルテゾミブおよびデキサメタゾン療法後に維持透析から離脱したBence-Jones蛋白質λ型多発性骨髄腫患者(Bence-Jones Protein λ-type Multiple Myeloma Patient Withdrawn from Maintenance Hemodialysis after Long-term Bortezomib and Dexamethasone Therapy) Internal Medicine. 2016.02; 55 (3): 263-268. ( ichushi )

  9. Yamaguchi W, Yui N, Nagao T, Oshikawa G, Negi M, Iimori S, Okado T, Rai T, Uchida S. Bence-Jones Protein λ-type Multiple Myeloma Patient Withdrawn from Maintenance Hemodialysis after Long-term Bortezomib and Dexamethasone Therapy. Internal medicine (Tokyo, Japan). 2016; 55 (3): 263-8. ( PubMed, DOI )

  10. Iimori S, Naito S, Noda Y, Nishida H, Kihira H, Yui N, Okado T, Sasaki S, Uchida S, Rai T. Anaemia management and mortality risk in newly visiting patients with chronic kidney disease in Japan: The CKD-ROUTE study. Nephrology (Carlton, Vic.). 2015.09; 20 (9): 601-8. ( PubMed, DOI )

  11. Yoshizaki Yuki, Yui Naofumi, Okado Tomokazu, Ishigami Junichi, Iimori Soichiro, Oi Katusyuki, Sohara Eisei, Sasaki Sei, Rai Tatemitsu, Uchida Shinichi. 慢性腎疾患における後腹膜線維化症(Retroperitoneal Fibrosis in Chronic Kidney Disease) General Medicine. 2015.06; 16 (2): 103-106. ( ichushi )

  12. Oi Katsuyuki, Okado Tomokazu, Togo Hisako, Iimori Soichiro, Yui Naofumi, Sohara Eisei, Kanda Eiichiro, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. 血液透析関連chronic portal-systemic shunt encephalopathy(CPSE)で、血液透析時に血中アンモニア濃度が正反対の変化を示した2症例 症例報告と文献レビュー(Two Cases of Hemodialysis-associated Chronic Portal-systemic Shunt Encephalopathy(CPSE) with Opposite Changes in the Blood Ammonia Concentrations during Hemodialysis: A Case Report and Literature Review) Internal Medicine. 2015.06; 54 (11): 1375-1380. ( ichushi )

  13. Oi K, Okado T, Togo H, Iimori S, Yui N, Sohara E, Kanda E, Rai T, Sasaki S, Uchida S. Two Cases of Hemodialysis-associated Chronic Portal-systemic Shunt Encephalopathy (CPSE) with Opposite Changes in the Blood Ammonia Concentrations during Hemodialysis: A Case Report and Literature Review. Internal medicine (Tokyo, Japan). 2015; 54 (11): 1375-80. ( PubMed, DOI )

  14. Sasaki S, Yui N, Noda Y. Actin directly interacts with different membrane channel proteins and influences channel activities: AQP2 as a model. Biochimica et biophysica acta. 2014.02; 1838 (2): 514-20. ( PubMed, DOI )

  15. Nomura N, Kamiya K, Ikeda K, Yui N, Chiga M, Sohara E, Rai T, Sakaki S, Uchida S. Treatment with 17-allylamino-17-demethoxygeldanamycin ameliorated symptoms of Bartter syndrome type IV caused by mutated Bsnd in mice. Biochemical and biophysical research communications. 2013.11; 441 (3): 544-9. ( PubMed, DOI )

  16. Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD Jr, Hallows KR, Brown D, Bouley R, Vilardaga JP. Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin. The Journal of biological chemistry. 2013.09; 288 (39): 27849-60. ( PubMed, DOI )

  17. Yui N, Lu HA, Chen Y, Nomura N, Bouley R, Brown D. Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel. American journal of physiology. Cell physiology. 2013.01; 304 (1): C38-48. ( PubMed, DOI )

  18. Yui N, Lu HJ, Bouley R, Brown D. AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cells. Biology open. 2012.02; 1 (2): 101-8. ( PubMed, DOI )

  19. Yui N, Okutsu R, Sohara E, Rai T, Ohta A, Noda Y, Sasaki S, Uchida S. FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells. American journal of physiology. Cell physiology. 2009.12; 297 (6): C1389-96. ( PubMed, DOI )

  20. Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S. Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Human molecular genetics. 2009.10; 18 (20): 3978-86. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Naofumi Yui, Sei Sasaki, Shinichi Uchida. Regulated Ser-261 Dephosphorylation Combined with Ser-256 and Ser-269 Phosphorulation in the C-terminus of Aquaporin-2 Water Channel. American Society of Nephrology 2016.11.18 Chicago

  2. Yui Naofumi, Sasaki Sei, Uchida Shinichi. Dephosphorylation at Ser-261 is a determinant for the regulated AQP2 apical accumulation. Th 48th Annual Meeting of American Society of Nephrology 2015.11 San Diego, USA

  3. Naofumi Yui, Sei Sasaki, Shinichi Uchida. Increased Phosphorylation of Ser-269 Is Not Sufficient for Regulated AQP2 Apical Accumulation. American Society of Nephrology 2014.11.15 Philadelphia

  4. Wakaba Yamaguchi, Naofumi Yui, Toshikage Nagao, Haruna Azetsu, Soichiro Iimori, Eisei Sohara, Tomokazu Okado, Tatemitsu Rai, Sei Sasaki, Shinichi Uchida . BJP lambda-Type Multiple Myeloma Successfully Withdrawn from Maintenance Hemodialysis after Long-Term Continuous Bortezomib and Dexamethasone Therapy. American Society of Nephrology 2014.11.13 Philadelphia