Personnel Information

写真a

KAGECHIKA Hiroyuki


Job title

Professor

Homepage URL

http://www.tmd.ac.jp/i-mde/www/en/biomolecular/index3.html

Research Areas, Keywords

Medicinal chemistry, Chemical biology, Organic chemistry

Graduating School 【 display / non-display

  • The University of Tokyo, Faculty of Pharmaceutical Science, 1983.03, Graduated

Graduate School 【 display / non-display

  • The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Master's Course, 1985.03, Completed

  • The University of Tokyo, Graduate School, Division of Pharmaceutical Sciences, Doctor's Course, 1985.08, Unfinished Course

Campus Career 【 display / non-display

  • 2012.04
    -
    2016.02
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Biomolecular Chemistry, Organic and Medicinal Chemistry, Professor
  • 2012.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Life Science and Technology, Life Science and Technology, Organic and Medicinal Chemistry, Professor
  • 1985.09
    -
    Now
    Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Biomolecular Chemistry, Organic and Medicinal Chemistry, Professor
  • 2004.05
    -
    2012.03
    Tokyo Medical and Dental University, Biomedical Science PhD Program / Graduate School of Biomedical Science, Professor
 

Published Papers & Misc 【 display / non-display

  • Ishigami-Yuasa, M.; Ekimoto, H.; Kagechika, H.. Class IIb HDAC inhibition enhances the inhibitory effect of Am80, a synthetic retinoid, in prostate cancer Biol. Pharm. Bull.. 2019.03; 42 (3): 448-452. ( DOI )

  • Urushibara, K.; Masu, H.; Mori, H.; Azumaya, I.; Hirano, T.; Kagechika,H.; Tanatani, A. . Synthesis and Conformational Analysis of Alternately N-Alkylated Aromatic Amide Oligomers J. Org. Chem.. 2018.11; 83 (23): 14338-14349. ( DOI )

  • Timalsina, S.; Arimoto-Matsuzaki, K.; Kitamura, M.; Xu, X.; Wenzhe, Q.; Ishigami-Yuasa, M.; Kagechika, H.; Hata, Y.. Chemical compounds that suppress hypoxia-induced stress granule formation enhance cancer drug sensitivity of human cervical cancer HeLa cells. J. Biochem.. 2018.10; 164 381-391. ( DOI )

  • Kazui, Y.; Fujii, S.; Yamada, A.; Ishigami-Yuasa, M.; Kagechika, H.; Tanatani, A.. Structure-Activity Relationship of Novel Androgen Receptor Antagonists Bearing a (Benzoylaminophenoxy)phenol Pharmacophore. Bioorg. Med. Chem.. 2018.10; 26 5118-5127. ( DOI )

  • Loppi, S.; Kolosowska, N.; Kärkkäinen, O.; Korhonen, P.; Huuskonen, M.; Grubman, A.; Dhungana, H.; Wojciechowski, S.; Pomeshchik, Y.; Giordano, M.; Kagechika, H.; White, A.; Auriola, S.; Koistinaho, J.; Landreth, G.; Hanhineva, K.; Kanninen, K.; Malm, T.. HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, preventsischemia-induced neuronal damag Brain Behav. Immunol.. 2018.09; 73 670-681. ( DOI )

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Conference Activities & Talks 【 display / non-display

  • 諸墨樹、森修一、影近弘之. カルボランを疎水性骨格として有する核内受容体LRH-1機能制御剤の創製. 日本薬学会第139年会 2019.03.20 東京

  • Hiroyuki Kagechika, Shinya Fujii, Tomoya Hirano, Shinya Mori, Aya Tanatani. Development of Functional Molecules Based on Unique Scaffolds. EPFL/TMDU/UTokyo Joint Symposium 2018 2018.09.19 Lausanne, Switzland

  • Soyoung Park, Junya Uchida, Ko Urushibara, Hiroyuki Kagechika, Takashi Kato, AyaTanatani. Self-assembly of Liquid-Crystalline Squaramides. 27th International Liquid Crystal Conference 2018.06.22 京都

  • Hidetomo Yokoo, Tomoya Hirano, Ayumi Ohsaki, Hiroyuki Kagechika. Development of novel environment-dependent fluorophore derived from fluorescent natural compounds. Gordon Research Conference, Bioanalytical Sensors 2018.06.22 Newport, RI, USA

  • Tomoya Hirano, Chihiro Komatsu, Yuki Noji, Hiroyuki Kagechika. Development of photofunctional compounds that function under specific range of pH with “OFF-ON-OFF” type of change. Gordon Research Conference, Bioanalytical Sensors 2018.06.22 Newport, RI, USA

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Patents 【 display / non-display

  • LONG-TERM MEMORY INDUCING AGENT

    Patent Number: 10266482

  • Myogenesis Promotor, Muscle Atrophy Inhibitor, Medical Composition and Taz Activator

    Patent Number: 10653672

Awards & Honors 【 display / non-display

  • The Vitamin Society of Japan Award,Vitamin Society of Japan,2016.06