論文・総説 - 小早川　拓也

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  1. Higashi-Kuwata N, Bulut H, Hayashi H, Tsuji K, Ogata-Aoki H, Kiso M, Takamune N, Kishimoto N, Hattori SI, Ishii T, Kobayakawa T, Nakano K, Shimizu Y, Das D, Saruwatari J, Hasegawa K, Murayama K, Sukenaga Y, Takamatsu Y, Yoshimura K, Aoki M, Furusawa Y, Okamura T, Yamayoshi S, Kawaoka Y, Misumi S, Tamamura H, Mitsuya H. An orally available P1'-5-fluorinated M(pro) inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier. PNAS nexus. 2025.01; 4 (1): pgae578. ( PubMed, DOI )

  2. Shinohara K, Kobayakawa T, Tsuji K, Takamatsu Y, Mitsuya H, Tamamura H. Naphthalen-1-ylethanamine-containing small molecule inhibitors of the papain-like protease of SARS-CoV-2. European journal of medicinal chemistry. 2024.12; 280 116963. ( PubMed, DOI )

  3. Kobayakawa T, Tsuji K, Tamamura H. Design, synthesis and evaluation of bioactivity of peptidomimetics based on chloroalkene dipeptide isosteres. Bioorganic & medicinal chemistry. 2024.08; 110 117811.

  4. Kobayakawa, T; Azuma, C; Yamamoto, K; Tsuji, K; Tamamura, H. | Convergent synthesis of peptidomimetic based on a chloroalkene dipeptide isostere and its application to inhibition against amyloid ß aggregation JOURNAL OF PEPTIDE SCIENCE. 2024.08; 30

  5. Tamamura, H; Higashi-Kuwata, N; Mitsuya, H; Tsuji, K; Ishii, T; Kobayakawa, T. Prevention of the spread of virus infection in global societies: anti-SARS-CoV-2 agents learned from HIV researches JOURNAL OF PEPTIDE SCIENCE. 2024.08; 30

  6. Ishii T, Kobayakawa T, Matsuda K, Nigorikawa K, Bolah P, Noborio A, Tsuji K, Ohashi N, Yoshimura K, Nomura W, Mitsuya H, Maeda K, Tamamura H. Discovery of Potent DAG-Lactone Derivatives as HIV Latency Reversing Agents. ACS infectious diseases. 2024.05; 10 (6): 2250-2261. ( PubMed, DOI )

  7. Kobayakawa Takuya, Yokoyama Masaru, Tsuji Kohei, Boku Sayaka, Kurakami Masaki, Fujino Masayuki, Ishii Takahiro, Miura Yutaro, Nishimura Soshi, Shinohara Kouki, Yamamoto Kenichi, Bolah Peter, Kotani Osamu, Murakami Tsutomu, Sato Hironori, Tamamura Hirokazu. Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins(タイトル和訳中) Chemical & Pharmaceutical Bulletin. 2024.01; 72 (1): 41-47. ( 医中誌 )

  8. Kobayakawa T, Takano H, Ishii T, Bolah P, Tsuji K, Ohashi N, Nomura W, Furuta T, Tamamura H. Effect of Two-Photon Excitation to 8-Azacoumarin Derivatives as Photolabile Protecting Groups. Chemical & pharmaceutical bulletin. 2024; 72 (3): 311-312. ( PubMed, DOI )

  9. Kobayakawa T, Yokoyama M, Tsuji K, Boku S, Kurakami M, Fujino M, Ishii T, Miura Y, Nishimura S, Shinohara K, Yamamoto K, Bolah P, Kotani O, Murakami T, Sato H, Tamamura H. Development of Small-Molecule Anti-HIV-1 Agents Targeting HIV-1 Capsid Proteins. Chemical & pharmaceutical bulletin. 2024; 72 (1): 41-47. ( PubMed, DOI )

  10. Tsuji Kohei, Kobayakawa Takuya, Ishii Takahiro, Higashi-Kuwata Nobuyo, Azuma Chika, Shinohara Kouki, Miura Yutaro, Yamamoto Kenichi, Nishimura Soshi, Hattori Shin-ichiro, Bulut Haydar, Mitsuya Hiroaki, Tamamura Hirokazu. Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement(タイトル和訳中) Chemical & Pharmaceutical Bulletin. 2023.12; 71 (12): 879-886. ( 医中誌 )

  11. Tsuji K, Ishii T, Kobayakawa T, Higashi-Kuwata N, Shinohara K, Azuma C, Miura Y, Nakano H, Wada N, Hattori SI, Bulut H, Mitsuya H, Tamamura H. Structure-Activity Relationship Studies of SARS-CoV-2 Main Protease Inhibitors Containing 4-Fluorobenzothiazole-2-carbonyl Moieties. Journal of medicinal chemistry. 2023.09; 66 (19): 13516-13529. ( PubMed, DOI )

  12. Ishii T, Kobayakawa T, Matsuda K, Tsuji K, Ohashi N, Nakahata S, Noborio A, Yoshimura K, Mitsuya H, Maeda K, Tamamura H. Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity. European journal of medicinal chemistry. 2023.08; 256 115449. ( PubMed, DOI )

  13. Kohei Tsuji, Kofi Baffour-Awuah Owusu, Yutaro Miura, Takahiro Ishii, Kouki Shinohara, Takuya Kobayakawa, Akino Emi, Takashi Nakano, Youichi Suzuki, Hirokazu Tamamura . Dimerized fusion inhibitor peptides targeting the HR1–HR2 interaction of SARS-CoV-2 RSC Advances. 2023.03; 13 8779-8793.

  14. Higashi-Kuwata N, Tsuji K, Hayashi H, Bulut H, Kiso M, Imai M, Ogata-Aoki H, Ishii T, Kobayakawa T, Nakano K, Takamune N, Kishimoto N, Hattori SI, Das D, Uemura Y, Shimizu Y, Aoki M, Hasegawa K, Suzuki S, Nishiyama A, Saruwatari J, Shimizu Y, Sukenaga Y, Takamatsu Y, Tsuchiya K, Maeda K, Yoshimura K, Iida S, Ozono S, Suzuki T, Okamura T, Misumi S, Kawaoka Y, Tamamura H, Mitsuya H. Identification of SARS-CoV-2 M(pro) inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2. Nature communications. 2023.02; 14 (1): 1076. ( PubMed, DOI )

  15. Tsuji K, Kobayakawa T, Ishii T, Higashi-Kuwata N, Azuma C, Shinohara K, Miura Y, Yamamoto K, Nishimura S, Hattori SI, Bulut H, Mitsuya H, Tamamura H. Exploratory Studies of Effective Inhibitors against the SARS-CoV-2 Main Protease by Halogen Incorporation and Amide Bond Replacement. Chemical & pharmaceutical bulletin. 2023; 71 (12): 879-886. ( PubMed, DOI )

  16. Matsuura K, Yamaura M, Sakawaki H, Himeno A, Pisil Y, Kobayakawa T, Tsuji K, Tamamura H, Matsushita S, Miura T. Sensitivity to a CD4 mimic of a consensus clone of monkey-adapted CCR5-tropic SHIV-MK38C. Virology. 2022.12; 578 171-179. ( PubMed, DOI )

  17. Kitamura H, Sukegawa S, Matsuda K, Tanimoto K, Kobayakawa T, Takahashi K, Tamamura H, Tsuchiya K, Gatanaga H, Maeda K, Takeuchi H. 4-phenylquinoline-8-amine induces HIV-1 reactivation and apoptosis in latently HIV-1 infected cells. Biochemical and biophysical research communications. 2022.12; 641 139-147. ( PubMed, DOI )

  18. Matsumoto K, Kuwata T, Tolbert WD, Richard J, Ding S, Prévost J, Takahama S, Judicate GP, Ueno T, Nakata H, Kobayakawa T, Tsuji K, Tamamura H, Smith AB 3rd, Pazgier M, Finzi A, Matsushita S. Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates. Journal of virology. 2022.12; 97 (1): e0163822. ( PubMed, DOI )

  19. Tsuji K, Ishii T, Kobayakawa T, Higashi-Kuwata N, Azuma C, Nakayama M, Onishi T, Nakano H, Wada N, Hori M, Shinohara K, Miura Y, Kawada T, Hayashi H, Hattori SI, Bulut H, Das D, Takamune N, Kishimoto N, Saruwatari J, Okamura T, Nakano K, Misumi S, Mitsuya H, Tamamura H. Potent and biostable inhibitors of the main protease of SARS-CoV-2. iScience. 2022.11; 105365. ( PubMed, DOI )

  20. Tsuji K, Ishii T, Kobayakawa T, Higashi-Kuwata N, Azuma C, Nakayama M, Onishi T, Nakano H, Wada N, Hori M, Shinohara K, Miura Y, Kawada T, Hayashi H, Hattori SI, Bulut H, Das D, Takamune N, Kishimoto N, Saruwatari J, Okamura T, Nakano K, Misumi S, Mitsuya H, Tamamura H. Potent and biostable inhibitors of the main protease of SARS-CoV-2. iScience. 2022.11; 105365. ( PubMed, DOI )

  21. Tsuji K, Kobayakawa T, Konno K, Masuda A, Takahashi K, Ohashi N, Yoshimura K, Kuwata T, Matsushita S, Harada S, Tamamura H. Exploratory studies on soluble small molecule CD4 mimics as HIV entry inhibitors. Bioorganic & medicinal chemistry. 2022.01; 56 116616. ( PubMed, DOI )

  22. Tsuji Kohei, Ishii Takahiro, Kobayakawa Takuya, Ohashi Nami, Nomura Wataru, Tamamura Hirokazu. Fluorescence resonance energy transfer-based screening for protein kinase C ligands using 6-methoxynaphthalene-labeled 1,2-diacylglycerol-lactones ORGANIC & BIOMOLECULAR CHEMISTRY. 2021.07; 19 (38): 8264-8271. ( PubMed, DOI )

  23. Kobayakawa T, Azuma C, Watanabe Y, Sawamura S, Taniguchi A, Hayashi Y, Tsuji K, Tamamura H. Development of Methods for Convergent Synthesis of Chloroalkene Dipeptide Isosteres and Its Application. The Journal of organic chemistry. 2021.04; 86 (7): 5091-5101. ( PubMed, DOI )

  24. Kobayakawa T, Yokoyama M, Tsuji K, Fujino M, Kurakami M, Boku S, Nakayama M, Kaneko M, Ohashi N, Kotani O, Murakami T, Sato H, Tamamura H. Small-Molecule Anti-HIV-1 Agents Based on HIV-1 Capsid Proteins. Biomolecules. 2021.02; 11 (2): ( PubMed, DOI )

  25. Kobayakawa T, Tsuji K, Konno K, Himeno A, Masuda A, Yang T, Takahashi K, Ishida Y, Ohashi N, Kuwata T, Matsumoto K, Yoshimura K, Sakawaki H, Miura T, Harada S, Matsushita S, Tamamura H. Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors. Journal of medicinal chemistry. 2021.01; ( PubMed, DOI )

  26. Kouki Matsuda, Takuya Kobayakawa, Ryusho Kariya, Kiyoto Tsuchiya, Kohei Tsuji, Takahiro Ishii, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Seiji Okada, Hiroaki Mitsuya, Hirokazu Tamamura & Kenji Maeda. A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators. Frontiers in Microbiology. 2021; 12 636276. ( PubMed, DOI )

  27. Takuya Kobayakawa, Hirokazu Tamamura. Chloroalkene dipeptide isosteres as peptidomimetics. Methods in enzymology. 2021; 656 191-239. ( PubMed, DOI )

  28. Kobayakawa Takuya, Ebihara Kento, Tsuji Kohei, Kawada Takuma, Fujino Masayuki, Honda Yuzuna, Ohashi Nami, Murakami Tsutomu, Tamamura Hirokazu. Bivalent HIV-1 fusion inhibitors based on peptidomimetics BIOORGANIC & MEDICINAL CHEMISTRY. 2020.12; 28 (24): 115812. ( PubMed, DOI )

  29. Tsuji K, Wang R, Kobayakawa T, Owusu KB, Fujino M, Kaneko M, Yamamoto N, Murakami T, Tamamura H. Potent leads based on CA-19L, an anti-HIV active HIV-1 capsid fragment. Bioorganic & medicinal chemistry. 2020.12; 30 115923. ( PubMed, DOI )

  30. Kohei Tsuji, Kofi Baffour-Awuah Owusu, Takuya Kobayakawa, Rongyi Wang, Masayuki Fujino, Moemi Kaneko, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura. Exploratory studies on CA-15L, an anti-HIV active HIV-1 capsid fragment. Bioorg. Med. Chem. 2020.06; 28 (11): 115488. ( PubMed, DOI )

  31. Takuya Kobayakawa, Hikaru Takano, Takahiro Ishii, Kohei Tsuji, Nami Ohashi, Wataru Nomura, Toshiaki Furuta, Hirokazu Tamamura. Synthesis of hydrophilic caged DAG-lactones for chemical biology applications. Org. Biomol. Chem. 2020.05; 18 (22): 4217-4223 . ( PubMed, DOI )

  32. Maeda Kenji, Matsuda Kouki, Islam Saiful, Kobayakawa Takuya, Tsuchiya Kiyoto, Hattori Shin-ichiro, Gatanaga Hiroyuki, Oka Shinichi, Yoshimura Kazuhisa, Tamamura Hirokazu, Mitsuya Hiroaki, Satou Yorifumi. HIV持続潜伏感染に関する最先端研究(Treatment of HIV-1-reservoirs using latency-reversing agents(LRAs) toward HIV cure) 日本エイズ学会誌. 2019.11; 21 (4): 314. ( 医中誌 )

  33. Takuya Kobayakawa, Kento Ebihara, Yuzuna Honda, Masayuki Fujino, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura. Dimeric C34 Derivatives Linked through Disulfide Bridges as New HIV-1 Fusion Inhibitors. Chembiochem. 2019.08; 20 (16): 2101-2108. ( PubMed, DOI )

  34. Kenji Maeda, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura, Hiroaki Takeuchi. Discovery and Development of anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication. Current topics in medicinal chemistry. 2019.07; 19 (18): 1621-1649. ( PubMed, DOI )

  35. Maxwell M Sakyiamah, Wataru Nomura, Takuya Kobayakawa, Hirokazu Tamamura. Development of a NanoBRET-Based Sensitive Screening Method for CXCR4 Ligands. Bioconjug. Chem.. 2019.05; 30 (5): 1442-1450. ( PubMed, DOI )

  36. Maxwell M. Sakyiamah, Takuya Kobayakawa, Masayuki Fujino, Makoto Konno, Tetsuo Narumi, Tomohiro Tanaka, Wataru Nomura, Naoki Yamamoto, Tsutomu Murakami, Hirokazu Tamamura. Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands BIOORGANIC & MEDICINAL CHEMISTRY. 2019.03; 27 (6): 1130-1138. ( PubMed, DOI )

  37. Takuya Kobayakawa, Kiju Konno, Nami Ohashi, Kohei Takahashi, Ami Masuda, Kazuhisa Yoshimura, Shigeyoshi Harada, Hirokazu Tamamura. Soluble-type small-molecule CD4 mimics as HIV entry inhibitors. Bioorg. Med. Chem. Lett.. 2019.03; 29 (5): 719-723. ( PubMed, DOI )

  38. Kouki Matsuda, Takuya Kobayakawa, Kiyoto Tsuchiya, Shin-Ichiro Hattori, Wataru Nomura, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Shinichi Oka, Yasuyuki Endo, Hirokazu Tamamura, Hiroaki Mitsuya, Kenji Maeda. Benzolactam-related compounds promote apoptosis of HIV-infected human cells via protein kinase C-induced HIV latency reversal. J. Biol. Chem.. 2019.01; 294 (1): 116-129. ( PubMed, DOI )

  39. Wataru Nomura, Daisuke Matsumoto, Taisuke Sugii, Takuya Kobayakawa, Hirokazu Tamamura. Efficient and Orthogonal Transcription Regulation by Chemically Inducible Artificial Transcription Factors. Biochemistry. 2018.11; 57 (45): 6452-6459. ( PubMed, DOI )

  40. Takuya Kobayakawa, Nami Ohashi, Yuki Hirota, Kohei Takahashi, Yuko Yamada, Tetsuo Narumi, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada, Hirokazu Tamamura. Flexibility of small molecular CD4 mimics as HIV entry inhibitors. Bioorg. Med. Chem.. 2018.11; 26 (21): 5664-5671. ( PubMed, DOI )

  41. Kei Toyama, Wataru Nomura, Takuya Kobayakawa, Hirokazu Tamamura. Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR. Bioconjug. Chem.. 2018.06; 29 (6): 2050-2057. ( PubMed, DOI )

  42. Wataru Nomura, Daisuke Matsumoto, Taisuke Sugii, Takuya Kobayakawa. Chemically-controlled orthogonal regulation of multiple endogenous genes FASEB Journal. 2018.04; 32 (1):

  43. Takuya Kobayakawa, Yudai Matsuzaki, Kentaro Hozumi, Wataru Nomura, Motoyoshi Nomizu, Hirokazu Tamamura. Synthesis of a Chloroalkene Dipeptide Isostere-Containing Peptidomimetic and Its Biological Application. ACS Medicinal Chemistry Letters. 2018.01; 9 (1): 6-10. ( PubMed, DOI )

  44. Kei Toyama, Takuya Kobayakawa, Wataru Nomura, Hirokazu Tamamura. Inhibition of EGFR Activation by Bivalent Ligands Based on a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR. Chem. Pharm. Bull.. 2018; 66 (11): 1083-1089. ( PubMed, DOI )

  45. Takuya Kobayakawa, Hirokazu Tamamura. Stereoselective synthesis of Xaa-Yaa type (Z)-chloroalkene dipeptide isosteres via efficient utilization of organocopper reagents mediated allylic alkylation Tetrahedron. 2017.07; 73 (30): 4464-4471. ( DOI )

  46. Takuya Kobayakawa. Synthetic Studies on Chloroalkene Dipeptide Isosteres as Peptidomimetics 国立大学法人 東京医科歯科大学. 2017.03;

  47. Takuya Kobayakawa, Hirokazu Tamamura. Efficient synthesis of Xaa-Gly type (Z)-chloroalkene dipeptide isosteres via organocuprate mediated reduction Tetrahedron. 2016.08; 72 (32): 4968-4971. ( DOI )

  48. Kobayakawa Takuya, Tamamura Hirokazu. Development of synthetic methodology of chloroalkene-type dipeptide isosteres for peptidomimetics ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2016.08; 252

  49. Takuya Kobayakawa, Tetsuo Narumi, Hirokazu Tamamura. Stereoselective Synthesis of Chloroalkene Dipeptide Isosteres Utilizing Organocopper Reagents PEPTIDE SCIENCE 2015. 2016.03; 97-98.

  50. Takuya Kobayakawa, Tetsuo Narumi, Hirokazu Tamamura. Remote Stereoinduction in the Organocuprate-Mediated Allylic Alkylation of Allylic gem-Dichlorides: Highly Diastereoselective Synthesis of (Z)-Chloroalkene Dipeptide Isosteres. Organic Letters. 2015.05; 17 (10): 2302-2305. ( PubMed, DOI )

  51. Takuya Kobayakawa, Tetsuo Narumi, Hirokazu Tamamura. Development of Efficient Synthetic Methodologies of Chloroalkene Dipeptide Isosteres PEPTIDE SCIENCE 2014. 2015.03; 13-14.

  52. Tetsuo Narumi, Haruo Aikawa, Tomohiro Tanaka, Chie Hashimoto, Nami Ohashi, Wataru Nomura, Takuya Kobayakawa, Hikaru Takano, Yuki Hirota, Tsutomu Murakami, Naoki Yamamoto, Hirokazu Tamamura. Low-molecular-weight CXCR4 ligands with variable spacers. ChemMedChem. 2013.01; 8 (1): 118-124. ( PubMed, DOI )

  53. Tetsuo Narumi, Takuya Kobayakawa, Haruo Aikawa, Shunsuke Seike, Hirokazu Tamamura. Stereoselective formation of trisubstituted (Z)-chloroalkenes adjacent to a tertiary carbon stereogenic center by organocuprate-mediated reduction/alkylation. Organic Letters. 2012.09; 14 (17): 4490-4493. ( PubMed, DOI )

  54. 小早川 拓也. 医薬化学　SARS-CoV-2パパイン様プロテアーゼに対する共有結合性阻害薬の開発 ファルマシア. 2024.03; 60 (3): 235. ( 医中誌 )

  55. Kobayakawa Takuya, Amano Masayuki, Nakayama Miyuki, Tsuji Kohei, Ishii Takahiro, Miura Yutaro, Shinohara Kouki, Yamamoto Kenichi, Matsuoka Masao, Tamamura Hirokazu. Development of anti-HBV agents targeting HBV capsid proteins RSC MEDICINAL CHEMISTRY. 2023.08; 14 (10): 1973-1980. ( PubMed, DOI )

  56. 小早川 拓也. ペプチドミメティックを活用したアミロイドβ凝集機構の解明と創薬展開 医科学応用研究財団研究報告. 2023.02; 40 295-299. ( 医中誌 )

  57. Kobayakawa Takuya, Yokoyama Masaru, Tsuji Kohei, Fujino Masayuki, Kurakami Masaki, Onishi Takato, Boku Sayaka, Ishii Takahiro, Miura Yutaro, Shinohara Kouki, Kishihara Yuki, Ohashi Nami, Kotani Osamu, Murakami Tsutomu, Sato Hironori, Tamamura Hirokazu. Low-molecular-weight anti-HIV-1 agents targeting HIV-1 capsid proteins RSC ADVANCES. 2023.01; 13 (3): 2156-2167. ( PubMed, DOI )

  58. Rongyi Wang, Kohei Tsuji, Takuya Kobayakawa, Yishan Liu, Kazuhisa Yoshimura, Shuzo Matsushita, Shigeyoshi Harada, Hirokazu Tamamura. Hybrids of small CD4 mimics and gp41-related peptides as dual-target HIV entry inhibitors BIOORGANIC & MEDICINAL CHEMISTRY. 2022.12; 76 117083. ( PubMed, DOI )

  59. Tsuji Kohei, Wang Rongyi, Owusu B. -A. Kofi, Kobayakawa Takuya, Murakami Tsutomu, Tamamura Hirokazu. Exploration of novel class anti-HIV-1 agents derived from a viral capsid protein JOURNAL OF PEPTIDE SCIENCE. 2022.08; 28

  60. 石井 貴大, 小早川 拓也, 松田 幸樹, 辻 耕平, 吉村 和久, 満屋 裕明, 前田 賢次, 玉村 啓和. HIV感染症の根治へ向けたDAG-ラクトン誘導体の構造活性相関研究 日本薬学会年会要旨集. 2021.03; 141年会 29V03-pm04S. ( 医中誌 )

  61. 小早川 拓也. Aβ凝集阻害を指向したペプチドミメティックの開発 上原記念生命科学財団研究報告集. 2020.12; 34 1-4. ( 医中誌 )

  62. 村上 努, 小早川 拓也, 倉上 真樹, 横山 勝, 小谷 治, 辻 耕平, 佐藤 裕徳, 玉村 啓和. カプシド二量体化を標的とした新規抗HIV-1低分子化合物の解析 日本エイズ学会誌. 2020.11; 22 (4): 461. ( 医中誌 )

  63. 玉村啓和, 小早川拓也, 辻耕平. 環状ペプチドで標的細胞へターゲティングする 「Drug Delivery System」特集“中分子創薬とDDS”. 2020.07; 35 (3): 170-180.

  64. 玉村 啓和, 小早川 拓也, 辻 耕平. 【中分子創薬とDDS】環状ペプチドで標的細胞へターゲティングする Drug Delivery System. 2020.07; 35 (3): 170-180. ( 医中誌 )

  65. 松田 幸樹, 服部 真一朗, 土屋 亮人, 小早川 拓也, 潟永 博之, 吉村 和久, 岡 慎一, 遠藤 泰之, 玉村 啓和, 満屋 裕明, 前田 賢次. HIV再活性化に伴うアポトーシス誘導能を用いたHIVリザーバー除去に資する新たなShock&Kill療法の可能性 日本エイズ学会誌. 2019.11; 21 (4): 474. ( 医中誌 )

  66. 村上 努, 海老原 健人, 小早川 拓也, 藤野 真之, 児玉 栄一, 玉村 啓和. 二量体化HIV-1膜融合阻害剤の作用機構 日本エイズ学会誌. 2019.11; 21 (4): 427. ( 医中誌 )

  67. 小早川拓也, 玉村啓和. クロロアルケン骨格を基盤としたペプチドミメティック化学への展開 有機合成化学協会誌 総合論文. 2019.09; 77 (9): 904-911.

  68. 小早川拓也, 玉村啓和. ペプチドミメティック 有機合成化学協会誌 十字路. 2019.09; 77 (9): 923.

  69. 小早川拓也. オキセタニル骨格を活用したペプチドミメティック化学への展開 有機合成化学協会誌 Review de Debut. 2019.07; 77 (7): 720-721.

  70. 村上 努, 海老原 健人, 藤野 真之, 本田 柚子奈, 小早川 拓也, 野村 渉, 玉村 啓和. 二量体化に基づいた新規抗HIV-1膜融合阻害薬の創出 日本エイズ学会誌. 2018.11; 20 (4): 523. ( 医中誌 )

  71. 松田 幸樹, 服部 真一朗, 土屋 亮人, 小早川 拓也, 大橋 南美, 野村 渉, 原田 恵嘉, 佐藤 賢文, 吉村 和久, 玉村 啓和, 満屋 裕明, 前田 賢次. HIV潜伏感染細胞を標的とした新規治療薬開発に有効なin vitro評価系の開発 日本エイズ学会誌. 2017.11; 19 (4): 403. ( 医中誌 )

  72. 小早川 拓也. 有機銅試薬によるクロロアルケン類の立体選択的合成法の開発とその応用 国立大学法人 東京医科歯科大学. 2014.03;

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