論文・総説 - 三宅　健介

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  1. Junya Ito, Kensuke Miyake, Tomoki Chiba, Kazufusa Takahashi, Yutaro Uchida, Perry J Blackshear, Hiroshi Asahara, Hajime Karasuyama. Tristetraprolin-mediated mRNA destabilization regulates basophil inflammatory responses. Allergol Int. 2025.04; 74 (2): 263-273. ( PubMed, DOI )

  2. Hitoshi Urakami, Soichiro Yoshikawa, Kei Nagao, Kensuke Miyake, Yuki Fujita, Ayaka Komura, Miho Nakashima, Ryusuke Umene, Shuhei Sano, Zheyu Hu, Emi Nishii, Atsushi Fujimura, Takeshi Y Hiyama, Keiji Naruse, Hajime Karasuyama, Tsuyoshi Inoue, Mitsutoshi Tominaga, Kenji Takamori, Shin Morizane, Sachiko Miyake. -adrenergic receptor in skin allergic inflammation. J Allergy Clin Immunol. 2025.03; 155 (3): 865-879. ( PubMed, DOI )

  3. Miyake K, Ito J, Karasuyama H. Novel insights into the ontogeny of basophils. Frontiers in allergy. 2024.05; 5 1402841. ( PubMed, DOI )

  4. Tchen J, Simon Q, Chapart L, Thaminy MK, Vibhushan S, Saveanu L, Lamri Y, Saidoune F, Pacreau E, Pellefigues C, Bex-Coudrat J, Karasuyama H, Miyake K, Hidalgo J, Fallon PG, Papo T, Blank U, Benhamou M, Hanouna G, Sacre K, Daugas E, Charles N. PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus. Nature communications. 2024.04; 15 (1): 3389. ( PubMed, DOI )

  5. Leyva-Castillo JM, Vega-Mendoza D, Strakosha M, Deng L, Choi S, Miyake K, Karasuyama H, Chiu IM, Phipatanakul W, Geha RS. Basophils are important for the development of allergic skin inflammation. The Journal of allergy and clinical immunology. 2024.02; 153 (5): 1344-1354.e5. ( PubMed, DOI )

  6. Miyake K, Ito J, Takahashi K, Nakabayashi J, Brombacher F, Shichino S, Yoshikawa S, Miyake S, Karasuyama H. Single-cell transcriptomics identifies the differentiation trajectory from inflammatory monocytes to pro-resolving macrophages in a mouse skin allergy model. Nature communications. 2024.02; 15 (1): 1666. ( PubMed, DOI )

  7. Nelson M LaMarche, Samarth Hegde, Matthew D Park, Barbara B Maier, Leanna Troncoso, Jessica Le Berichel, Pauline Hamon, Meriem Belabed, Raphaël Mattiuz, Clotilde Hennequin, Theodore Chin, Amanda M Reid, Iván Reyes-Torres, Erika Nemeth, Ruiyuan Zhang, Oakley C Olson, Deborah B Doroshow, Nicholas C Rohs, Jorge E Gomez, Rajwanth Veluswamy, Nicole Hall, Nicholas Venturini, Florent Ginhoux, Zhaoyuan Liu, Mark Buckup, Igor Figueiredo, Vladimir Roudko, Kensuke Miyake, Hajime Karasuyama, Edgar Gonzalez-Kozlova, Sacha Gnjatic, Emmanuelle Passegué, Seunghee Kim-Schulze, Brian D Brown, Fred R Hirsch, Brian S Kim, Thomas U Marron, Miriam Merad. An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis. Nature. 2024.01; 625 (7993): 166-174. ( PubMed, DOI )

  8. Strakosha M, Vega-Mendoza D, Kane J, Jain A, Sun L, Rockowitz S, Elkins M, Miyake K, Chou J, Karasuyama H, Geha RS, Leyva-Castillo JM. Basophils play a protective role in the recovery of skin barrier function from mechanical injury in mice. The Journal of investigative dermatology. 2024.01; 144 (8): 1784-1797.e4. ( PubMed, DOI )

  9. Takahashi K, Miyake K, Ito J, Shimamura H, Suenaga T, Karasuyama H, Ohashi K. Topical application of a PDE4 inhibitor ameliorates atopic dermatitis through inhibition of basophil IL-4 production. The Journal of investigative dermatology. 2023.10; 144 (5): 1048-1057.e8. ( PubMed, DOI )

  10. Nagashima N, Ugajin T, Miyake K, Walls AF, Namiki T, Yokozeki H, Karasuyama H, Okiyama N. Cutaneous basophil infiltration in atopic dermatitis is associated with abundant epidermal infiltration of helper T cells: A preliminary retrospective study. The Journal of dermatology. 2023.10; 51 (1): 130-134. ( PubMed, DOI )

  11. Miyake K, Ito J, Nakabayashi J, Shichino S, Ishiwata K, Karasuyama H. Single cell transcriptomics clarifies the basophil differentiation trajectory and identifies pre-basophils upstream of mature basophils. Nature communications. 2023.05; 14 (1): 2694. ( PubMed, DOI )

  12. Tchen John, Simon Quentin, Chapart Lea, Pellefigues Christophe, Karasuyama Hajime, Miyake Kensuke, Blank Ulrich, Benhamou Marc, Daugas Eric, Charles Nicolas. CT-M8 Mice: A New Mouse Model Demonstrates That Basophils Have a Nonredundant Role in Lupus-Like Disease Development Fronteirs in Immunology. 2022.06; 13 900532. ( PubMed, DOI )

  13. Miyake Kensuke, Ito Junya, Karasuyama Hajime. Role of Basophils in a Broad Spectrum of Disorders Frontiers in Immunology. 2022.05; 13 902494. ( PubMed, DOI )

  14. Kensuke Miyake, Sho Shibata, Soichiro Yoshikawa, Hajime Karasuyama. Basophils and their effector molecules in allergic disorders. Allergy. 2021.06; 76 (6): 1693-1706. ( PubMed, DOI )

  15. Karasuyama H, Shibata S, Yoshikawa S, Miyake K. Basophils, a neglected minority in the immune system, have come into the limelight at last. International immunology. 2021.05; 33 (12): 809-813. ( PubMed, DOI )

  16. Kensuke Miyake, Hajime Karasuyama. The Role of Trogocytosis in the Modulation of Immune Cell Functions. Cells. 2021.05; 10 (5): ( PubMed, DOI )

  17. Anaïs Wanet, Mahmoud A Bassal, Sweta B Patel, Francisco Marchi, Samanta A Mariani, Nouraiz Ahmed, Haoran Zhang, Marta Borchiellini, Sisi Chen, Junyan Zhang, Annalisa Di Ruscio, Kensuke Miyake, Mindy Tsai, Anuya Paranjape, Shin-Young Park, Hajime Karasuyama, Timm Schroeder, Elaine Dzierzak, Stephen J Galli, Daniel G Tenen, Robert S Welner. E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates. Sci Immunol. 2021.02; 6 (56): ( PubMed, DOI )

  18. Yamanishi Y, Mogi K, Takahashi K, Miyake K, Yoshikawa S, Karasuyama H. Skin-infiltrating basophils promote atopic dermatitis-like inflammation via IL-4 production in mice. Allergy. 2020.10; 75 (10): 2613-2622. ( PubMed, DOI )

  19. Yoshikawa S, Miyake K, Kamiya A, Karasuyama H. The role of basophils in acquired protective immunity to tick infestation. Parasite immunology. 2020.10; 43 (5): e12804. ( PubMed, DOI )

  20. Karasuyama Hajime, Miyake Kensuke, Yoshikawa Soichiro. Immunobiology of Acquired Resistance to Ticks FRONTIERS IN IMMUNOLOGY. 2020.10; 11 601504. ( PubMed, DOI )

  21. Yang Yue, Nagai Shigenori, Kang Siwen, Xia Yulong, Kawano Yohei, Miyake Kensuke, Karasuyama Hajime, Azuma Miyuki. Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting International Immunology. 2020.08; 32 (8): 509-518. ( 医中誌 )

  22. Yue Yang, Shigenori Nagai, Siwen Kang, Yulong Xia, Yohei Kawano, Kensuke Miyake, Hajime Karasuyama, Miyuki Azuma. Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting. Int. Immunol.. 2020.03; ( PubMed, DOI )

  23. Soichiro Yoshikawa, Masatsugu Oh-Hora, Ryota Hashimoto, Toshihisa Nagao, Louis Peters, Mayumi Egawa, Takuya Ohta, Kensuke Miyake, Takahiro Adachi, Yohei Kawano, Yoshinori Yamanishi, Hajime Karasuyama. Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils. Sci Signal. 2019.04; 12 (576): ( PubMed, DOI )

  24. Toshihisa Nagao, Yoshinori Yamanishi, Kensuke Miyake, Mio Teranishi, Saori Takahashi, Soichiro Yoshikawa, Yohei Kawano, Hajime Karasuyama. Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice. Int. Immunol.. 2019.02; 31 (1): 41-49. ( PubMed, DOI )

  25. Sho Shibata, Kensuke Miyake, Tomoya Tateishi, Soichiro Yoshikawa, Yoshinori Yamanishi, Yasunari Miyazaki, Naohiko Inase, Hajime Karasuyama. Basophils trigger emphysema development in a murine model of COPD through IL-4-mediated generation of MMP-12-producing macrophages Proc. Natl. Acad. Sci. U.S.A.. 2018.12; 115 (51): 13057-13062. ( PubMed, DOI )

  26. Hajime Karasuyama, Kensuke Miyake, Soichiro Yoshikawa, Yohei Kawano, Yoshinori Yamanishi. How do basophils contribute to T(h)2 cell differentiation and allergic responses? Int. Immunol.. 2018.09; 30 (9): 391-396. ( PubMed, DOI )

  27. Hajime Karasuyama, Kensuke Miyake, Soichiro Yoshikawa, Yoshinori Yamanishi. Multifaceted roles of basophils in health and disease. J. Allergy Clin. Immunol.. 2018.08; 142 (2): 370-380. ( PubMed, DOI )

  28. Yuya Tabakawa, Takuya Ohta, Soichiro Yoshikawa, Elisabeth J Robinson, Kayoko Yamaji, Kenji Ishiwata, Yohei Kawano, Kensuke Miyake, Yoshinori Yamanishi, Hiroshi Ohtsu, Takahiro Adachi, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama. Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice. Front. Immunol.. 2018.07; 9 1540. ( PubMed, DOI )

  29. Takuya Ohta, Soichiro Yoshikawa, Yuya Tabakawa, Kayoko Yamaji, Kenji Ishiwata, Hiroshi Shitara, Choji Taya, Masatsugu Oh-hora, Yohei Kawano, Kensuke Miyake, Yoshinori Yamanishi, Hiromichi Yonekawa, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama. Skin CD4(+) Memory T Cells Play an Essential Role in Acquired Anti-Tick Immunity through Interleukin-3-Mediated Basophil Recruitment to Tick-Feeding Sites Front. Immunol.. 2017.10; 8 1348. ( PubMed, DOI )

  30. Kensuke Miyake, Hajime Karasuyama. Emerging roles of basophils in allergic inflammation. Allergol. Int.. 2017.07; 66 (3): 382-391. ( PubMed, DOI )

  31. Yoshinori Yamanishi, Kensuke Miyake, Misako Iki, Hidemitsu Tsutsui, Hajime Karasuyama. Recent advances in understanding basophil-mediated Th2 immune responses Immunol. Rev.. 2017.07; 278 (1): 237-245. ( PubMed, DOI )

  32. Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Trogocytosis of peptide-MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils. Proc. Natl. Acad. Sci. U.S.A.. 2017.01; 114 (5): 1111-1116. ( PubMed, DOI )

  33. Kayo Horiguchi, Soichiro Yoshikawa, Asuka Saito, Salma Haddad, Takuya Ohta, Kensuke Miyake, Yoshinori Yamanishi, Hajime Karasuyama. Real-time imaging of mast cell degranulation in vitro and in vivo. Biochem. Biophys. Res. Commun.. 2016.10; 479 (3): 517-522. ( PubMed, DOI )

  34. 三宅健介、伊藤潤哉. RNA結合タンパク質による好塩基球およびアトピー性皮膚炎の制御 臨床皮膚科. 2025.04; 79 (5): 55-59.

  35. 三宅 健介, 伊藤 潤哉, 烏山 一. 【アトピー性皮膚炎のサイトカイン病態と治療の最前線】アトピー性皮膚炎病態における好塩基球の役割 臨床免疫・アレルギー科. 2024.08; 82 (2): 154-161. ( 医中誌 )

  36. 三宅 健介, 伊藤 潤哉, 烏山 一. 【ヒト疾患と免疫細胞サブセット　解像度をあげて見えてきた病態を規定する疾患のキープレーヤーと治療戦略】(第1章)自然免疫系　皮膚アレルギー炎症における好塩基球の役割 実験医学. 2024.08; 42 (12): 1812-1819. ( 医中誌 )

  37. 伊藤 潤哉, 三宅 健介, 烏山 一. 1細胞RNAシーケンス解析による好塩基球分化機構の解明 臨床免疫・アレルギー科. 2024.05; 81 (5): 497-503. ( 医中誌 )

  38. 三宅 健介, 伊藤 潤哉, 烏山 一. 好塩基球分化とその機能に関する新知見 日本薬理学雑誌. 2024.01; 159 (1): 32-38. ( PubMed, DOI, 医中誌 )

  39. 三宅 健介, 吉川 宗一郎, 烏山 一. 【蕁麻疹・血管性浮腫】蕁麻疹と好塩基球 皮膚科. 2023.02; 3 (2): 130-137. ( 医中誌 )

  40. 三宅 健介, 烏山 一. 【ファゴサイトーシスとトロゴサイトーシス】免疫細胞におけるトロゴサイトーシスの役割 臨床免疫・アレルギー科. 2022.02; 77 (2): 168-175. ( 医中誌 )

  41. 三宅 健介, 烏山 一. 【肺免疫から肺疾患を考える】アレルギー疾患や寄生虫感染症における好塩基球の役割 呼吸器内科. 2021.12; 40 (6): 535-542. ( 医中誌 )

  42. 三宅 健介, 烏山 一. いま知りたい!!かじる?呑み込む?貪食の多様性　トロゴサイトーシスとエフェロサイトーシス　トロゴサイトーシスによる免疫細胞機能の調節 実験医学. 2021.09; 39 (14): 2229-2232. ( 医中誌 )

  43. 三宅 健介, 烏山 一. 【アレルギーとリンパ球・マスト細胞・好塩基球-最新の知見-】アレルギー炎症における好塩基球の役割 アレルギーの臨床. 2021.02; 41 (2): 117-120. ( 医中誌 )

  44. 三宅 健介, 吉川 宗一郎, 柴田 翔, 烏山 一. 【血液疾患と血球分化】好塩基球の分化および活性化による2型免疫反応 血液内科. 2021.01; 82 (1): 54-61. ( 医中誌 )

  45. 三宅 健介, 吉川 宗一郎, 柴田 翔, 山西 吉典, 烏山 一. 【アレルギーのエフェクター細胞研究の進展】好塩基球 臨床免疫・アレルギー科. 2020.01; 73 (1): 6-13. ( 医中誌 )

  46. 三宅　健介, 烏山　一 . 好塩基球による、トロゴサイトーシスを介した新たな抗原提示メカニズム 感染・炎症・免疫. 2019.04; 49 (1): 61-64.

  47. 三宅 健介, 吉川 宗一郎, 山西 吉典, 烏山 一. Th2型免疫応答における好塩基球の役割 臨床免疫・アレルギー科. 2019.02; 71 (2): 177-184.

  48. 三宅 健介, 吉川 宗一郎, 山西 吉典, 烏山 一. Th2型免疫応答における好塩基球の役割 臨床免疫・アレルギー科. 2019.02; 71 (2): 177-184. ( 医中誌 )

  49. 三宅健介, 山西吉典, 烏山　一. トロゴサイトーシスを介した好塩基球による抗原提示機構 臨床免疫・アレルギー科. 2018.12; 70 (6): 623-630. ( 医中誌 )

  50. 三宅健介. 免疫学のABC(第8回)　顆粒球の作用と役割 分子リウマチ治療. 2018.07; 11 (3): 148-151. ( 医中誌 )

  51. 三宅健介, 烏山　一. 好塩基球（解説） 鼻アレルギー フロンティア. 2018.02; 18 (1): 22-23. ( 医中誌 )

  52. 三宅 健介, 烏山 一. 免疫学　Th2分化における好塩基球の役割 医学のあゆみ. 2017.09; 262 (13): 1183-1184. ( 医中誌 )

  53. 三宅健介, 烏山 一. 好塩基球 鼻アレルギーフロンティア. 2017.01; 18 (1): 22-23.

  54. 三宅健介, 烏山 一. Th2分化における好塩基球の役割 医学のあゆみ. 2017.01; 262 (13): 1183-1184.

  55. 三宅　健介、烏山　一 . アレルギーにおける好塩基球の役割（解説） 臨床免疫・アレルギー科. 2017.01; 67 (1): 74-81.

  56. 三宅 健介, 烏山 一. アレルギーにおける好塩基球の役割 臨床免疫・アレルギー科. 2017.01; 67 (1): 74-81. ( 医中誌 )

  57. 三宅　健介、烏山　一. 皮膚・粘膜における好塩基球の役割 医学のあゆみ. 2015.05; 253 (5): 410-420.

  58. 三宅　健介、烏山　一. 最近明らかになってきた好塩基球の役割 臨床免疫・アレルギー科. 2015.02; 63 (2): 164-169. ( 医中誌 )

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