Miyake K, Ito J, Takahashi K, Nakabayashi J, Brombacher F, Shichino S, Yoshikawa S, Miyake S, Karasuyama H. Single-cell transcriptomics identifies the differentiation trajectory from inflammatory monocytes to pro-resolving macrophages in a mouse skin allergy model. Nature communications. 2024.02; 15 (1): 1666. ( PubMed, DOI )

Nelson M LaMarche, Samarth Hegde, Matthew D Park, Barbara B Maier, Leanna Troncoso, Jessica Le Berichel, Pauline Hamon, Meriem Belabed, Raphaël Mattiuz, Clotilde Hennequin, Theodore Chin, Amanda M Reid, Iván Reyes-Torres, Erika Nemeth, Ruiyuan Zhang, Oakley C Olson, Deborah B Doroshow, Nicholas C Rohs, Jorge E Gomez, Rajwanth Veluswamy, Nicole Hall, Nicholas Venturini, Florent Ginhoux, Zhaoyuan Liu, Mark Buckup, Igor Figueiredo, Vladimir Roudko, Kensuke Miyake, Hajime Karasuyama, Edgar Gonzalez-Kozlova, Sacha Gnjatic, Emmanuelle Passegué, Seunghee Kim-Schulze, Brian D Brown, Fred R Hirsch, Brian S Kim, Thomas U Marron, Miriam Merad. An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis. Nature. 2024.01; 625 (7993): 166-174. ( PubMed, DOI )

Strakosha M, Vega-Mendoza D, Kane J, Jain A, Sun L, Rockowitz S, Elkins M, Miyake K, Chou J, Karasuyama H, Geha RS, Leyva-Castillo JM. Basophils play a protective role in the recovery of skin barrier function from mechanical injury in mice. The Journal of investigative dermatology. 2024.01; 144 (8): 1784-1797.e4. ( PubMed, DOI )

Takahashi K, Miyake K, Ito J, Shimamura H, Suenaga T, Karasuyama H, Ohashi K. Topical application of a PDE4 inhibitor ameliorates atopic dermatitis through inhibition of basophil IL-4 production. The Journal of investigative dermatology. 2023.10; 144 (5): 1048-1057.e8. ( PubMed, DOI )

Nagashima N, Ugajin T, Miyake K, Walls AF, Namiki T, Yokozeki H, Karasuyama H, Okiyama N. Cutaneous basophil infiltration in atopic dermatitis is associated with abundant epidermal infiltration of helper T cells: A preliminary retrospective study. The Journal of dermatology. 2023.10; 51 (1): 130-134. ( PubMed, DOI )

Miyake K, Ito J, Nakabayashi J, Shichino S, Ishiwata K, Karasuyama H. Single cell transcriptomics clarifies the basophil differentiation trajectory and identifies pre-basophils upstream of mature basophils. Nature communications. 2023.05; 14 (1): 2694. ( PubMed, DOI )

Tchen John, Simon Quentin, Chapart Lea, Pellefigues Christophe, Karasuyama Hajime, Miyake Kensuke, Blank Ulrich, Benhamou Marc, Daugas Eric, Charles Nicolas. CT-M8 Mice: A New Mouse Model Demonstrates That Basophils Have a Nonredundant Role in Lupus-Like Disease Development Fronteirs in Immunology. 2022.06; 13 900532. ( PubMed, DOI )

Miyake Kensuke, Ito Junya, Karasuyama Hajime. Role of Basophils in a Broad Spectrum of Disorders Frontiers in Immunology. 2022.05; 13 902494. ( PubMed, DOI )

Kensuke Miyake, Sho Shibata, Soichiro Yoshikawa, Hajime Karasuyama. Basophils and their effector molecules in allergic disorders. Allergy. 2021.06; 76 (6): 1693-1706. ( PubMed, DOI )

Karasuyama H, Shibata S, Yoshikawa S, Miyake K. Basophils, a neglected minority in the immune system, have come into the limelight at last. International immunology. 2021.05; 33 (12): 809-813. ( PubMed, DOI )

Kensuke Miyake, Hajime Karasuyama. The Role of Trogocytosis in the Modulation of Immune Cell Functions. Cells. 2021.05; 10 (5): ( PubMed, DOI )

Anaïs Wanet, Mahmoud A Bassal, Sweta B Patel, Francisco Marchi, Samanta A Mariani, Nouraiz Ahmed, Haoran Zhang, Marta Borchiellini, Sisi Chen, Junyan Zhang, Annalisa Di Ruscio, Kensuke Miyake, Mindy Tsai, Anuya Paranjape, Shin-Young Park, Hajime Karasuyama, Timm Schroeder, Elaine Dzierzak, Stephen J Galli, Daniel G Tenen, Robert S Welner. E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates. Sci Immunol. 2021.02; 6 (56): ( PubMed, DOI )

Yamanishi Y, Mogi K, Takahashi K, Miyake K, Yoshikawa S, Karasuyama H. Skin-infiltrating basophils promote atopic dermatitis-like inflammation via IL-4 production in mice. Allergy. 2020.10; 75 (10): 2613-2622. ( PubMed, DOI )

Yoshikawa S, Miyake K, Kamiya A, Karasuyama H. The role of basophils in acquired protective immunity to tick infestation. Parasite immunology. 2020.10; 43 (5): e12804. ( PubMed, DOI )

Karasuyama Hajime, Miyake Kensuke, Yoshikawa Soichiro. Immunobiology of Acquired Resistance to Ticks FRONTIERS IN IMMUNOLOGY. 2020.10; 11 601504. ( PubMed, DOI )

Yang Yue, Nagai Shigenori, Kang Siwen, Xia Yulong, Kawano Yohei, Miyake Kensuke, Karasuyama Hajime, Azuma Miyuki. Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting International Immunology. 2020.08; 32 (8): 509-518. ( 医中誌 )

Yue Yang, Shigenori Nagai, Siwen Kang, Yulong Xia, Yohei Kawano, Kensuke Miyake, Hajime Karasuyama, Miyuki Azuma. Tolerogenic properties of CD206+ macrophages appeared in the sublingual mucosa after repeated antigen-painting. Int. Immunol.. 2020.03; ( PubMed, DOI )

Soichiro Yoshikawa, Masatsugu Oh-Hora, Ryota Hashimoto, Toshihisa Nagao, Louis Peters, Mayumi Egawa, Takuya Ohta, Kensuke Miyake, Takahiro Adachi, Yohei Kawano, Yoshinori Yamanishi, Hajime Karasuyama. Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils. Sci Signal. 2019.04; 12 (576): ( PubMed, DOI )

Toshihisa Nagao, Yoshinori Yamanishi, Kensuke Miyake, Mio Teranishi, Saori Takahashi, Soichiro Yoshikawa, Yohei Kawano, Hajime Karasuyama. Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice. Int. Immunol.. 2019.02; 31 (1): 41-49. ( PubMed, DOI )

Sho Shibata, Kensuke Miyake, Tomoya Tateishi, Soichiro Yoshikawa, Yoshinori Yamanishi, Yasunari Miyazaki, Naohiko Inase, Hajime Karasuyama. Basophils trigger emphysema development in a murine model of COPD through IL-4-mediated generation of MMP-12-producing macrophages Proc. Natl. Acad. Sci. U.S.A.. 2018.12; 115 (51): 13057-13062. ( PubMed, DOI )

Hajime Karasuyama, Kensuke Miyake, Soichiro Yoshikawa, Yohei Kawano, Yoshinori Yamanishi. How do basophils contribute to T(h)2 cell differentiation and allergic responses? Int. Immunol.. 2018.09; 30 (9): 391-396. ( PubMed, DOI )

Hajime Karasuyama, Kensuke Miyake, Soichiro Yoshikawa, Yoshinori Yamanishi. Multifaceted roles of basophils in health and disease. J. Allergy Clin. Immunol.. 2018.08; 142 (2): 370-380. ( PubMed, DOI )

Yuya Tabakawa, Takuya Ohta, Soichiro Yoshikawa, Elisabeth J Robinson, Kayoko Yamaji, Kenji Ishiwata, Yohei Kawano, Kensuke Miyake, Yoshinori Yamanishi, Hiroshi Ohtsu, Takahiro Adachi, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama. Histamine Released From Skin-Infiltrating Basophils but Not Mast Cells Is Crucial for Acquired Tick Resistance in Mice. Front. Immunol.. 2018.07; 9 1540. ( PubMed, DOI )

Takuya Ohta, Soichiro Yoshikawa, Yuya Tabakawa, Kayoko Yamaji, Kenji Ishiwata, Hiroshi Shitara, Choji Taya, Masatsugu Oh-hora, Yohei Kawano, Kensuke Miyake, Yoshinori Yamanishi, Hiromichi Yonekawa, Naohiro Watanabe, Hirotaka Kanuka, Hajime Karasuyama. Skin CD4(+) Memory T Cells Play an Essential Role in Acquired Anti-Tick Immunity through Interleukin-3-Mediated Basophil Recruitment to Tick-Feeding Sites Front. Immunol.. 2017.10; 8 1348. ( PubMed, DOI )

Kensuke Miyake, Hajime Karasuyama. Emerging roles of basophils in allergic inflammation. Allergol. Int.. 2017.07; 66 (3): 382-391. ( PubMed, DOI )

Yoshinori Yamanishi, Kensuke Miyake, Misako Iki, Hidemitsu Tsutsui, Hajime Karasuyama. Recent advances in understanding basophil-mediated Th2 immune responses Immunol. Rev.. 2017.07; 278 (1): 237-245. ( PubMed, DOI )

Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Trogocytosis of peptide-MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils. Proc. Natl. Acad. Sci. U.S.A.. 2017.01; 114 (5): 1111-1116. ( PubMed, DOI )

Kayo Horiguchi, Soichiro Yoshikawa, Asuka Saito, Salma Haddad, Takuya Ohta, Kensuke Miyake, Yoshinori Yamanishi, Hajime Karasuyama. Real-time imaging of mast cell degranulation in vitro and in vivo. Biochem. Biophys. Res. Commun.. 2016.10; 479 (3): 517-522. ( PubMed, DOI )

三宅 健介, 伊藤 潤哉, 烏山 一. 【アトピー性皮膚炎のサイトカイン病態と治療の最前線】アトピー性皮膚炎病態における好塩基球の役割 臨床免疫・アレルギー科. 2024.08; 82 (2): 154-161. ( 医中誌 )

三宅 健介, 伊藤 潤哉, 烏山 一. 【ヒト疾患と免疫細胞サブセット　解像度をあげて見えてきた病態を規定する疾患のキープレーヤーと治療戦略】(第1章)自然免疫系　皮膚アレルギー炎症における好塩基球の役割 実験医学. 2024.08; 42 (12): 1812-1819. ( 医中誌 )

伊藤 潤哉, 三宅 健介, 烏山 一. 1細胞RNAシーケンス解析による好塩基球分化機構の解明 臨床免疫・アレルギー科. 2024.05; 81 (5): 497-503. ( 医中誌 )

三宅 健介, 伊藤 潤哉, 烏山 一. 好塩基球分化とその機能に関する新知見 日本薬理学雑誌. 2024.01; 159 (1): 32-38. ( PubMed, DOI, 医中誌 )

三宅 健介, 吉川 宗一郎, 烏山 一. 【蕁麻疹・血管性浮腫】蕁麻疹と好塩基球 皮膚科. 2023.02; 3 (2): 130-137. ( 医中誌 )

三宅 健介, 烏山 一. 【ファゴサイトーシスとトロゴサイトーシス】免疫細胞におけるトロゴサイトーシスの役割 臨床免疫・アレルギー科. 2022.02; 77 (2): 168-175. ( 医中誌 )

三宅 健介, 烏山 一. 【肺免疫から肺疾患を考える】アレルギー疾患や寄生虫感染症における好塩基球の役割 呼吸器内科. 2021.12; 40 (6): 535-542. ( 医中誌 )

三宅 健介, 烏山 一. いま知りたい!!かじる?呑み込む?貪食の多様性　トロゴサイトーシスとエフェロサイトーシス　トロゴサイトーシスによる免疫細胞機能の調節 実験医学. 2021.09; 39 (14): 2229-2232. ( 医中誌 )

三宅 健介, 烏山 一. 【アレルギーとリンパ球・マスト細胞・好塩基球-最新の知見-】アレルギー炎症における好塩基球の役割 アレルギーの臨床. 2021.02; 41 (2): 117-120. ( 医中誌 )

三宅 健介, 吉川 宗一郎, 柴田 翔, 烏山 一. 【血液疾患と血球分化】好塩基球の分化および活性化による2型免疫反応 血液内科. 2021.01; 82 (1): 54-61. ( 医中誌 )

三宅 健介, 吉川 宗一郎, 柴田 翔, 山西 吉典, 烏山 一. 【アレルギーのエフェクター細胞研究の進展】好塩基球 臨床免疫・アレルギー科. 2020.01; 73 (1): 6-13. ( 医中誌 )

三宅　健介, 烏山　一 . 好塩基球による、トロゴサイトーシスを介した新たな抗原提示メカニズム 感染・炎症・免疫. 2019.04; 49 (1): 61-64.

三宅 健介, 吉川 宗一郎, 山西 吉典, 烏山 一. Th2型免疫応答における好塩基球の役割 臨床免疫・アレルギー科. 2019.02; 71 (2): 177-184.

三宅 健介, 吉川 宗一郎, 山西 吉典, 烏山 一. Th2型免疫応答における好塩基球の役割 臨床免疫・アレルギー科. 2019.02; 71 (2): 177-184. ( 医中誌 )

三宅健介, 山西吉典, 烏山　一. トロゴサイトーシスを介した好塩基球による抗原提示機構 臨床免疫・アレルギー科. 2018.12; 70 (6): 623-630. ( 医中誌 )

三宅健介. 免疫学のABC(第8回)　顆粒球の作用と役割 分子リウマチ治療. 2018.07; 11 (3): 148-151. ( 医中誌 )

三宅健介, 烏山　一. 好塩基球（解説） 鼻アレルギー フロンティア. 2018.02; 18 (1): 22-23. ( 医中誌 )

三宅 健介, 烏山 一. 免疫学　Th2分化における好塩基球の役割 医学のあゆみ. 2017.09; 262 (13): 1183-1184. ( 医中誌 )

三宅健介, 烏山 一. 好塩基球 鼻アレルギーフロンティア. 2017.01; 18 (1): 22-23.

三宅健介, 烏山 一. Th2分化における好塩基球の役割 医学のあゆみ. 2017.01; 262 (13): 1183-1184.

三宅　健介、烏山　一 . アレルギーにおける好塩基球の役割（解説） 臨床免疫・アレルギー科. 2017.01; 67 (1): 74-81.

三宅 健介, 烏山 一. アレルギーにおける好塩基球の役割 臨床免疫・アレルギー科. 2017.01; 67 (1): 74-81. ( 医中誌 )

三宅　健介、烏山　一. 皮膚・粘膜における好塩基球の役割 医学のあゆみ. 2015.05; 253 (5): 410-420.

三宅　健介、烏山　一. 最近明らかになってきた好塩基球の役割 臨床免疫・アレルギー科. 2015.02; 63 (2): 164-169. ( 医中誌 )

Junya Ito, Kensuke Miyake, Kazufusa Takahashi, Shigeyuki Shichino, Hajime Karasuyama. FoxO1 regulates the number of basophils in the peripheral tissues and basophil-dependent allergic inflammation. The 52nd Annual Meeting of the Japanese Society for Immunology 2024.01.17 Chiba, Japan

Kensuke Miyake. Pro-Resolving Roles for Basophils and Monocyte-Derived Macrophages in IgE-Mediated Skin Allergy. 2024 Food Allergy Conference GRC 2024.01.11 Ventura, CA

Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Jun Nakabayashi, Shigeyuki Shichino, Hajime Karasuyama. Classical monocyte differentiate into pro-resolving macrophages with high efferocytic capacity in basophil-dependent skin allergy. The 46th Annual Meeting of the Molecular Biology Society of Japan 2023.12.08 Kobe, Japan

Junya Ito, Kensuke Miyake, Kazufusa Takahashi, Shigeyuki Shichino, Hajime Karasuyama. Transcriptomic and functional analyses uncover an immature subpopulation of basophils in the bone marrow and FoxO1 as a transcription factor involved in the regulation of basophil responsiveness. 51st Annual Meeting of Japanese Society for Immunology 2022.12.08 Kumamato, Japan

Kazufusa Takahashi, Kensuke Miyake, Junya Ito, Hinano Shimamura, Hajime Karasuyama. Difamilast, a selective phosphodiesterase 4 inhibitor, suppresses IL-4 production by basophils and ameliorates atopic dermatitis in a murine model. 51st Annual Meeting of Japanese Society for Immunology 2022.12.08 Kumamato, Japan

Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Jun Nakabayashi, Shigeyuki Shichino, Hajime Karasuayma. M2 macrophages generated in the termination phase of skin allergic inflammation display high efferocytic capacity and promote resolution of inflammation. 51st Annual Meeting of Japanese Society for Immunology 2022.12.07 Kumamato, Japan

Hitoshi Urakami, Yuki Fujita, Kei Nagao, Kensuke Miiyake, Hajime Karasuyama, Sachiko Miyake, Soichiro Yoshikawa. Chronic psychological stress exacerbates IgE-dependent chronic allergic inflammation by supressing M2 macrophage-mediated efferocytosis. 51st Annual Meeting of Japanese Society for Immunology 2022.12.07 Kumamato, Japan

Nagashima Natsumi, Ugajin Tsukasa, Miyake Kensuke, Karasuyama Hajime, Namiki Takeshi, Okiyama Naoko. The clinical and histological characteristics of 'basophil-high' atopic dermatitis(タイトル和訳中). 日本研究皮膚科学会年次学術大会・総会プログラム 2022.10.01

Urakami Hitoshi, Fujita Yuki, Komura Ayaka, Nagao Kei, Matsui Keigo, Hino Shota, Miyake Kensuke, Karasuyama Hajime, Yoshikawa Soichiro, Kamiya Atsunori, Morizane Shin. Psychological stress exacerbates skin allergic inflammation by dysfunction of anti-inflammatory M2 macrophages via β2-adrenergic receptor(タイトル和訳中). 日本研究皮膚科学会年次学術大会・総会プログラム 2022.10.01

Nagashima Natsumi, Ugajin Tsukasa, Miyake Kensuke, Karasuyama Hajime, Namiki Takeshi, Okiyama Naoko. "好塩基球の多い"アトピー性皮膚炎の臨床的および組織学的特徴(The clinical and histological characteristics of 'basophil-high' atopic dermatitis). 日本研究皮膚科学会年次学術大会・総会プログラム 2022.10.01

Nagashima Natsumi, Ugajin Tsukasa, Miyake Kensuke, Karasuyama Hajime, Namiki Takeshi, Okiyama Naoko. "好塩基球の多い"アトピー性皮膚炎の臨床的および組織学的特徴(The clinical and histological characteristics of 'basophil-high' atopic dermatitis). 日本研究皮膚科学会年次学術大会・総会プログラム 2022.10.01

Miyake K. Takahashi K, Ito J, Nakabayashi J, Shichino S, Yoshikawa S, Karasuyama H.. Basophils promote the generation of highly phagocytic M2 macrophages which dampen excess inflammation at the resolution phase of allergic inflammation.. 50th Annual Meeting of Japanese Society for Immunology 2021.12.11 Nara, Japan

Ma N, Kishimoto I, Kambe N, Nakashima C, Otsuka A, Miyake K, Karasuyama H, Tanizaki H.. Basophil dynamics during the activate phase of urticaria using an Oxazolone-induced contact hypersensitivity mouse model.. 50th Annual Meeting of Japanese Society for Immunology 2021.12.10 Nara, Japan

Miyake K.. Single-cell RNA-seq analysis provides novel insights into the mechanism underlying the termination of basophil-elicited allergic inflammation in the skin.. 50th Annual Meeting of Japanese Society for Immunology 2021.12.10 Nara, Japan

Urakami H, Fujita Y, Komura A, Nagao K, Okutani R, Miyake K, Karasuyama H, Yoshikawa S.. Chronic psychological stress exacerbates IgE-dependent chronic allergic inflammation via symphathetic nerve.. 50th Annual Meeting of Japanese Society for Immunology 2021.12.10 Nara, Japan

Takahashi K, Miyake K, Karasuyama H.. Sphingosine kinase 1 contributes to IgE-dependent basophil activation and the development of basophil-dependent delayed-onset skin allergic inflammation.. 50th Annual Meeting of Japanese Society for Immunology 2021.12.10 Nara, Japan

Ito J, Miyake K, Nakabayashi J, Shichino S, Karasuyama H.. Single-cell RNA-seq analysis identified a novel subpopulation of basophils with immature phenotypes and unique functionality.. 50th Annual Meeting of Japanese Society for Immunology 2021.12.09 Nara, Japan

Miyake K, Karasuyama H. Basophils gain the capacity of antigen presentation via trogocytosis-mediated transfer of peptide-MHC class II complexes from DCs.. 第44回日本分子生物学会年会（MBSJ2021） 2021.12.02

Kensuke Miyake、Kazufusa Takahashi、Junya Ito、Jun Nakabayashi、Shigeyuki Shichino、Soichiro Yoshikawa、Hajime Karasuyama. Basophil-derived IL-4 induces the generation of M2 macrophages which dampen skin chronic allergic inflammation via the efferocytic clearance of dead cells. 第70回日本アレルギー学会学術大会 2021.10.10

Kensuke Miyake, Hajime Karasuyama. Basophils present antigens to T cells via trogocytosis-mediated acquisition of MHC class II. 第43回日本分子生物学会年会（MBSJ2020） 2020.12.04 on line meeting

Miyake Kensuke, Ito Junya, Takahashi Kazufusa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. Regulation of immune cells　Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation. アレルギー 2020.10.01

Ito Junya, Miyake Kensuke, Shichino Shigeyuki, Yamanishi Yoshinori, Karasuyama Hajime. Identification of two distinct subpopulations among basophils in the bone marrow. アレルギー 2020.10.01

Kensuke Miyake, Junya Ito, Kazufusa Takahashi, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation. JSA/WAO Joint Congress 2020 2020.09.17 On line meeting

Miyake K, Yoshikawa S, Yamanishi Y, Karasuyama H. Monocyte-derived M2-like macrophages induced by activated basophils dampen IL-1α-mediated aggravation of allergic inflammation. The 48th Annual Meeting of The Japanese Society for Immunology 2019.12.13 Hamamatsu, Japan

Ito J, Miyake K, Shichino S, Yamanishi Y, Karasuyama H. Identification of immature-type basophils that are distinguishable from mature ones in terms of surface phenotype and activation property. The 48th Annual Meeting of The Japanese Society for Immunology 2019.12.13 Hamamatsu, Japan

Mogi K, Takahashi K, Miyake K, Yoshikawa S, Karasuyama H, Yamanishi Y. Basophil-derived IL-4 promotes disease progression in a hapten-elicited murine model of atopic dermatitis. The 48th Annual Meeting of The Japanese Society for Immunology 2019.12.13 Hamamatsu, Japan

Yoshikawa S, Oh-hora M, Hashimoto R, Miyake K, Adachi T, Kawano Y, Yamanish Y, Kamiya A, Karasuyama H. Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated basophils. 17th IUIS 2019 (International Congress of Immunology) 2019.10.23 Beijing, China

Miyake K, Yoshikawa S, Yamanishi Y, Karasuyama H. Basophils promote the differentiation of monocytes into M2-like macrophages which dampen IL-1α-mediated aggravation of allergic inflammation. 17th IUIS 2019 (International Congress of Immunology) 2019.10.21 Beijing, China

Miyake K, Shiozawa N, Nagao T, Yoshikawa S, Yamanishi Y, Karasuyama H. Basophils exert antigen presentation through trogocytosis of peptide-MHC class II complexes from DCs. 8th NIF Winter School on Advanced Immunology 2019.01.20 Singapore

Miyake K, Fukui A, Yoshikawa S, Yamanishi Y, Karasuyama H. Basophils promote monocyte differentiation to M2-like macrophages that display enhanced capacity of allergen clearance. The 47th Annual Meeting of The Japanese Society for Immunology 2018.12.11 Fukuoka, Japan

Nagao Toshihisa, Yamanishi Yoshinori, Miyake Kensuke, Teranishi Mio, Yoshikawa Soichiro, Kawano Yohei, Karasuyama Hajime. Aggregation makes a protein allergenic at the challenge phase of basophil-mediated allergy in mice. The 47th Annual Meeting of The Japanese Society for Immunology 2018.12.11 Fukuoka, Japan

Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC class II complexes from dendritic cells (DCs). The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

Toshihisa Nagao, Mio Teranishi, Kensuke Miyake, Soichiro Yoshikawa, Yohei Kawano, Yoshinori Yamanishi, Hajime Karasuyama.. Sugar modification of carrier protein confers ability on allergen to induce IgE- and basophil-mediated allergic inflammation. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.14 Sendai, Japan

Yoshinori Yamanishi, Misako Iki, Kensei Tanaka, Hayato Deki, Mio Fujimaki, Kensuke Miyake, Soichiro Yoshikawa, Yohei Kawano, Shingo Sato, Hajime Karasuyama. Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.13 Sendai, Japan

Sho Shibata, Kensuke Miyake, Soichiro Yoshikawa, Yohei Kawano, Yoshinori Yamanishi, Hajime Karasuyama. Monocyte-derived macrophages in the lung contribute to the development of pulmonary emphysema through MMP12 production in a mouse model of COPD. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.12 Sendai, Japan

Soichiro Yoshikawa, Masatsugu Oh-hora, Kensuke Miyake, Yohei Kawano, Yoshinori Yamanishi, Hajime Karasuyama. Prolonged Ca2+ influx via STIM2 is essential for cytokine-induced IL-4 production in basophil. The 46th Annual Meeting of The Japanese Society for Immunology 2017.12.12 Sendai, Japan

SHIBATA Sho, MIYAKE Kensuke, YOSHIKAWA Soichiro, KAWANO Yohei, YAMANISHI Yoshinori, KARASUYAMA Hajime. COPDマウスモデルにおいて肺の単球由来マクロファージはMMP-12産生を通して肺気腫の発生に関与する(Allergy: Lower airway allergic inflammation　Monocyte-derived macrophages in the lung contribute to the development of pulmonary emphysema through MMP-12 production in a mouse model of COPD). 日本免疫学会総会・学術集会記録 2017.12.01

NAGAO Toshihisa, TERANISHI Mio, MIYAKE Kensuke, YOSHIKAWA Soichiro, KAWANO Yohei, YAMANISHI Yoshinori, KARASUYAMA Hajime. 顆粒球及びマスト細胞　担体タンパク質の糖修飾によりアレルゲンはIgEおよび好塩基球媒介性のアレルギー性炎症誘発能を獲得する(Granulocyte & Mast cells　Sugar modification of carrier protein confers ability on allergen to induce IgE- and basophil-mediated allergic inflammation). 日本免疫学会総会・学術集会記録 2017.12.01

Miyake Kensuke, Shiozawa Nozomu, Nagao Toshihisa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 顆粒球及びマスト細胞　好塩基球はトロゴサイトーシスを介して樹状細胞(DC)由来のペプチドMHCクラスII複合体を獲得し抗原を提示する(Granulocyte & Mast cells　Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC class II complexes from dendritic cells(DCs)). 日本免疫学会総会・学術集会記録 2017.12.01

Yamanishi Yoshinori, Iki Misako, Tanaka Kensei, Deki Hayato, Fujimaki Mio, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Sato Shingo, Karasuyama Hajime. アレルギー(3)　アレルギー性皮膚炎、食物アレルギー、アレルギー性結膜炎　IgE媒介性遅発性アレルギー性炎症において好塩基性tryptase mMCP-11は極めて重要な役割を果たす(Allergy: Allergic dermatitis, food allergy and allergic conjunctivitis　Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation). 日本免疫学会総会・学術集会記録 2017.12.01

Yoshikawa Soichiro, Oh-hora Masatsugu, Miyake Kensuke, Kawano Yohei, Yamanashi Yoshinori, Karasuyama Hajime. アレルギー(2)　上気道アレルギー性炎症とアレルギー反応　好塩基球におけるSTIM2を介した長期間にわたるCa2+の流入はサイトカイン誘導IL-4産生にとって不可欠である(Allergy: Upper airway allergic inflammation and allergic responses　Prolonged Ca2+ influx via STIM2 is essential for cytokine-induced IL-4 production in basophil). 日本免疫学会総会・学術集会記録 2017.12.01

SHIBATA Sho, MIYAKE Kensuke, YOSHIKAWA Soichiro, KAWANO Yohei, YAMANISHI Yoshinori, KARASUYAMA Hajime. COPDマウスモデルにおいて肺の単球由来マクロファージはMMP-12産生を通して肺気腫の発生に関与する(Allergy: Lower airway allergic inflammation　Monocyte-derived macrophages in the lung contribute to the development of pulmonary emphysema through MMP-12 production in a mouse model of COPD). 日本免疫学会総会・学術集会記録 2017.12.01

NAGAO Toshihisa, TERANISHI Mio, MIYAKE Kensuke, YOSHIKAWA Soichiro, KAWANO Yohei, YAMANISHI Yoshinori, KARASUYAMA Hajime. 顆粒球及びマスト細胞　担体タンパク質の糖修飾によりアレルゲンはIgEおよび好塩基球媒介性のアレルギー性炎症誘発能を獲得する(Granulocyte & Mast cells　Sugar modification of carrier protein confers ability on allergen to induce IgE- and basophil-mediated allergic inflammation). 日本免疫学会総会・学術集会記録 2017.12.01

Miyake Kensuke, Shiozawa Nozomu, Nagao Toshihisa, Yoshikawa Soichiro, Yamanishi Yoshinori, Karasuyama Hajime. 顆粒球及びマスト細胞　好塩基球はトロゴサイトーシスを介して樹状細胞(DC)由来のペプチドMHCクラスII複合体を獲得し抗原を提示する(Granulocyte & Mast cells　Basophils exert antigen presentation via trogocytosis-mediated acquisition of peptide-MHC class II complexes from dendritic cells(DCs)). 日本免疫学会総会・学術集会記録 2017.12.01

Yamanishi Yoshinori, Iki Misako, Tanaka Kensei, Deki Hayato, Fujimaki Mio, Miyake Kensuke, Yoshikawa Soichiro, Kawano Yohei, Sato Shingo, Karasuyama Hajime. アレルギー(3)　アレルギー性皮膚炎、食物アレルギー、アレルギー性結膜炎　IgE媒介性遅発性アレルギー性炎症において好塩基性tryptase mMCP-11は極めて重要な役割を果たす(Allergy: Allergic dermatitis, food allergy and allergic conjunctivitis　Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation). 日本免疫学会総会・学術集会記録 2017.12.01

Yoshikawa Soichiro, Oh-hora Masatsugu, Miyake Kensuke, Kawano Yohei, Yamanashi Yoshinori, Karasuyama Hajime. アレルギー(2)　上気道アレルギー性炎症とアレルギー反応　好塩基球におけるSTIM2を介した長期間にわたるCa2+の流入はサイトカイン誘導IL-4産生にとって不可欠である(Allergy: Upper airway allergic inflammation and allergic responses　Prolonged Ca2+ influx via STIM2 is essential for cytokine-induced IL-4 production in basophil). 日本免疫学会総会・学術集会記録 2017.12.01

Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Moe Kawawa, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Basophils gain the capacity of antigen presentation by acquiring MHC class II molecules from dendritic cells through trogocytosis. The 45th Annual Meeting of The Japanese Society for Immunology 2016.12.06 Okinawa, Japan

Nagao, T., Takahashi, S., Kawawa, M., Miyake, K., Yoshikawa, S., Yamanishi, Y., Karasuyama, H.. Sugar modification of carrier protein in allergen determines the magnitude of IgE- and basophil-mediated allergic inflammation. 16th International Congress of Immunology 2016.08.23 Melbourne, Australia

Miyake K., Shiozawa N., Nagao T., Yoshikawa S., Yamanishi Y., Karasuyama H.. Basophils gain the capacity of antigen presentation through the import of MHC class II molecules from dendritic cells. 16th International Congress of Immunology 2016.08.23 Melbourne, Australia

Kensuke Miyake, Nozomu Shiozawa, Toshihisa Nagao, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. Basophils acquire MHC class II molecules from DCs and exert antigen presenting capacity. The 44th Annual Meeting of The Japanese Society for Immunology 2015.11.18 Sapporo, Japan

Nagao T, Takahashi S, Kawawa M, Miyake K, Yoshikawa S, Sato S, Yamanishi Y, Karasuyama H.. Molecular properties of carrier protein in allergen are critical for the development of IgE-mediated chronic allergic inflammation in the skin: what makes a foreign material to be an allergen?. The 44th Annual Meeting of The Japanese Society for Immunology 2015.11.18 Sapporo, Japan

Kensuke Miyake, Toshihisa Nagao, Yuto Yahagi, Soichiro Yoshikawa, Yoshinori Yamanishi, Hajime Karasuyama. GM-CSF can promote MHC class II expression and ability of antigen presentation in basophils. The 64th Meeting of Japanese Society of Allergology 2015.05.26 Tokyo, Japan

MIYAKE Kensuke, NAGAO Toshihisa, YAHAGI Yuto, NUMAZAKI Takumi, YOSHIKAWA Soichiro, YAMANISHI Yoshinori, KARASUYAMA Hajime. GM-CSF-elicited basophils have increased capacity for antigen presentation.. The 43rd Annual Meeting of The Japanese Society for Immunology 2014.12.10 Kyoto, Japan

三宅健介. 1細胞解析によって解明された好塩基球の炎症制御機構. 順天堂大学アトピー疾患研究センター・国立成育医療研究センター　合同シンポジウム 2024.12.01 順天堂大学

伊藤潤哉、三宅健介、千葉朋希、浅原弘嗣、烏山一. RNA結合タンパク質Tristetraprolin（TTP）は好塩基球の活性化を抑制する. 第73回日本アレルギー学会学術大会 2024.10.19

三宅健介. シングルセルRNAシーケンス解析の活用による好塩基球の皮膚アレルギー制御機構の解明. 第73回日本アレルギー学会学術大会 2024.10.18 京都、日本

三宅健介. アレルギーにおける好塩基球の役割～アトピー性皮膚炎における役割を中心に～. 第73回日本アレルギー学会学術大会 2024.10.18 京都、日本

三宅　健介. Single-cell transcriptomics identifies the differentiation trajectory from inflammatory monocytes to pro-resolving macrophages in a mouse skin allergy model. 第19回血液学若手研究者勉強会（麒麟塾） 2024.06.29 東京

三宅健介. アトピー性皮膚炎における好塩基球の役割. 第123回日本皮膚科学会総会 2024.06.06 京都、日本

高澤 聖子, 三宅 健介, 杉原 潤, 柴田 翔, 立石 知也, 烏山 一, 宮崎 泰成. 増悪と抑制を司るアレルギーメディエーター　好塩基球由来IL-4は急性呼吸促迫症候群モデルの肺炎症を抑制する. 第72回日本アレルギー学会学術集会 2023.10.22 東京

高澤 聖子, 三宅 健介, 杉原 潤, 柴田 翔, 立石 知也, 烏山 一, 宮崎 泰成. 喘息　動物モデル　好塩基球由来IL-4は急性呼吸促迫症候群モデルの肺炎症を抑制する. 第63回日本呼吸器学会学術講演会 2023.04.29 東京

三宅 健介, 高橋 和総, 伊藤 潤哉, 島村 雛乃, 烏山 一. 新規PDE4阻害薬のジファミラストは好塩基球のIL-4産生を抑制し,アトピー性皮膚炎モデルへの治療効果を示す. 第52回日本皮膚免疫アレルギー学会総会学術大会 2022.12.16 オンライン

三宅健介、伊藤潤哉、髙橋和総、中林潤、七野成之、烏山一. 炎症後期に出現するM2マクロファージは高い死細胞貪食能を持ち、好塩基球依存的皮膚アレルギー炎症の収束に寄与する. 第96回日本薬理学会年会 2022.11.30 横浜、日本

吉川 宗一郎, 浦上 仁志, 藤田 悠紀, 長尾 圭, 日野 翔太, 松井 奎吾, 三宅 健介, 烏山 一, 森実 実, 神谷 厚範, 三宅 幸子. 精神的ストレスによるアレルギー皮膚炎症増悪メカニズムの解明. 第34回日本神経免疫学会 2022.10.20 長崎、日本

高橋 和総, 三宅 健介, 烏山 一. 新規PDE4阻害薬ジファミラストは好塩基球活性化を阻害し、アトピー性皮膚炎モデルに対し治療効果を示す. 第71回日本アレルギー学会学術集会 2022.08.01 東京、日本

長島 夏実, 宇賀神 つかさ, 三宅 健介, 烏山 一, 並木 剛. 好塩基球浸潤による成人アトピー性皮膚炎患者層別化の検討. 第121回日本皮膚科学会総会 2022.06.02 京都、日本

三宅 健介. 好塩基球・M2マクロファージによる皮膚慢性アレルギー炎症抑制機構の解明. 先進医薬研究振興財団研究成果報告集 2022.03.01

高橋 和総、三宅 健介、須田 真未、大橋 健一、烏山 一. 好塩基球由来IL-4はマクロファージのCCL24産生を促し，好酸球浸潤を誘導する. 第70回日本アレルギー学会学術大会 2021.10.10

伊藤 潤哉、三宅 健介、中林 潤、七野 成之、烏山 一. 成熟好塩基球とは異なる活性化能を呈する未熟好塩基球の新規同定. 第70回日本アレルギー学会学術大会 2021.10.08 横浜、日本

柴田 翔、三宅 健介、立石 知也、烏山 一、宮崎 泰成. マウス，ヒトにおいて好中球エラスターゼは好塩基球からのIL-4分泌を促進する. 第70回日本アレルギー学会学術大会 2021.10.08 横浜、日本

岸本 泉、馬 尼、谷崎 英昭、中嶋 千紗、大塚 篤司、三宅 健介、烏山 一、神戸 直智. 蕁麻疹の活動期に見られる好塩基球減少に関する動物モデルからの検証. 第70回日本アレルギー学会学術大会 2021.10.08

三宅　健介. 好塩基球は炎症抑制型のM2マクロファージを誘導することで、アレルギー炎症の悪化を妨げる. 2019年先端モデル動物支援若手技術支援講習会 2019.09.06 茅野

柴田 翔, 立石 知也, 小林 正嗣, 大久保 憲一, 明石 巧, 三宅 健介, 山西 吉典, 烏山 一, 宮崎 泰成. 慢性閉塞性肺疾患(COPD)患者の肺組織に好塩基球が浸潤している. 第68回日本アレルギー学会学術大会 2019.06.15 東京

三宅　健介, 　烏山　一. GM-CSFによって分化誘導された好塩基球は抗原提示能を示す. CREST「免疫機構」領域　第三回シンポジウム 2014.10.08 東京、日本

三宅　健介,　吉川　宗一郎,　矢作　雄人,　烏山　一. GM-CSFによって誘導した骨髄由来好塩基球は抗原提示能を有する. 第26回日本アレルギー学会春季臨床大会 2014.05.09 京都、日本

三宅　健介,吉川　宗一郎,大洞　将嗣,烏山　一. STIM1を介したストア作動性カルシウム流入は 好塩基球の脱顆粒および炎症局所への浸潤に重要である. 第63回日本アレルギー学会秋季学術大会 2013.11.28