Personnel Information

写真a

MANDAI Shintaro


Job title

Assistant Professor

Graduating School 【 display / non-display

  • Tokyo Medical and Dental University, Faculty of Medicine, 2008.03, Graduated

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Doctor's Course, 2018.03, Completed

Campus Career 【 display / non-display

  • 2018.04
    -
    2019.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Nephrology, Visiting Lecturer
  • 2019.04
    -
    2020.03
    Tokyo Medical and Dental University, Medical Hospital, Central Clinical Facilities, Hemopurification, Project Assistant Professor
  • 2020.04
    -
    2021.09
    Tokyo Medical and Dental University, Medical Hospital, Central Clinical Facilities, Hemopurification, Assistant Professor
  • 2021.10
    -
    Now
    Tokyo Medical and Dental University, Tokyo Medical and Dental University, Division of Integrated Facilities, Hemopurification, Assistant Professor

Research Areas 【 display / non-display

  • Molecular biology

  • Cell biology

  • Nephrology

  • General internal medicine

 

Published Papers & Misc 【 display / non-display

  1. Takaaki Koide, Shintaro Mandai*, Reo Kitaoka, Hisazumi Matsuki, Motoko Chiga, Kouhei Yamamoto, Kotaro Yoshioka, Yohsuke Yagi, Soichiro Suzuki, Tamami Fujiki, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Tatemitsu Rai, Takanori Yokota, Shinichi Uchida. Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease. Circ Res. 2023.01; ( PubMed, DOI )

  2. Nakano Y, Mandai S*, Genma T, Akagi Y, Fujiki T, Ando F, Susa K, Mori T, Iimori S, Naito S, Sohara E, Uchida S, Fushimi K, Rai T*.. Nationwide mortality associated with perioperative acute dialysis requirement in major surgeries. Int J Surg. 2022.08; 104 106816. ( PubMed, DOI )

  3. Hara Y, Ando F, Oikawa D, Ichimura K, Yanagawa H, Sakamaki Y, Nanamatsu A, Fujiki T, Mori S, Suzuki S, Yui N, Mandai S, Susa K, Mori T, Sohara E, Rai T, Takahashi M, Sasaki S, Kagechika H, Tokunaga F, Uchida S.. LRBA is essential for urinary concentration and body water homeostasis. Proc Natl Acad Sci U S A. 2022.07; 119 (30): e2202125119. ( PubMed, DOI )

  4. Mandai S*, Ando F, Mori T, Susa K, Iimori S, Naito S, Sohara E, Uchida S, Fushimi K, Rai T*.. Burden of kidney disease on the discrepancy between reasons for hospital admission and death: An observational cohort study. PLoS One. 2021.11; 16 (11): e0258846. ( PubMed, DOI )

  5. Nanamatsu A, Mori T, Ando F, Furusho T, Mandai S, Susa K, Sohara E, Rai T, Uchida S.. Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A). Hypertension. 2021.06; 77 (6): 1953-1963. ( PubMed, DOI )

  6. Mandai S, Yamada T, Uchihara T, Iida T, Ito T, Sato H, Sato K, Chida Y, Hirokawa K, Noda Y. Severe Dialysis-Related Amyloidosis Spared the Brain: An Autopsy Case of a Patient Receiving Hemodialysis for 41 Years. Journal of neuropathology and experimental neurology. 2021.03; ( PubMed, DOI )

  7. Hashimoto H, Shikuma S, Mandai S*, Adachi S, Uchida S.. Calcium-based phosphate binder use is associated with lower risk of osteoporosis in hemodialysis patients SCIENTIFIC REPORTS. 2021.01; 11 (1): 1648. ( PubMed, DOI )

  8. Noda S, Mandai S*, Oda T, Shinoto T, Sato H, Sato K, Hirokawa K, Noda Y, Uchida S.. Asymptomatic sinusitis as an origin of infection-related glomerulonephritis manifesting steroid-resistant nephrotic syndrome: A case report. Medicine (Baltimore). 2020.06; 99 (25): e20572. ( PubMed, DOI )

  9. Mandai S, Sato H, Iimori S, Naito S, Tanaka H, Ando F, Susa K, Isobe K, Mori T, Nomura N, Sohara E, Okado T, Uchida S, Fushimi K, Rai T. Nationwide in-hospital mortality following major fractures among hemodialysis patients and the general population: An observational cohort study. Bone. 2020.01; 130 115122. ( PubMed, DOI )

  10. Mandai S, Mori T, Nomura N, Furusho T, Arai Y, Kikuchi H, Sasaki E, Sohara E, Rai T, Uchida S.. WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4. Scientific Reports. 2018.06; 8 (1): 9101. ( PubMed, DOI )

  11. Mandai S, Sato H, Iimori S, Naito S, Mori T, Takahashi D, Zeniya M, Nomura N, Sohara E, Okado T, Uchida S, Fushimi K, Rai T.. Dialysis Case Volume Associated With In-Hospital Mortality in Maintenance Dialysis Patients. Kidney International Reports. 2018.03; 3 (2): 356-363. ( PubMed, DOI )

  12. Mandai S, Furukawa S, Kodaka M, Hata Y, Mori T, Nomura N, Ando F, Mori Y, Takahashi D, Yoshizaki Y, Kasagi Y, Arai Y, Sasaki E, Yoshida S, Furuichi Y, Fujii NL, Sohara E, Rai T, Uchida S.. Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy. Scientific Reports. 2017.04; 7 46369. ( PubMed, DOI )

  13. Mandai S, Kanda E, Iimori S, Naito S, Noda Y, Kikuchi H, Akazawa M, Oi K, Toda T, Sohara E, Okado T, Sasaki S, Rai T, Uchida S.. Association of serum chloride level with mortality and cardiovascular events in chronic kidney disease: the CKD-ROUTE study. Clin. Exp. Nephrol.. 2017.02; 21 (1): 104-111. ( PubMed, DOI )

  14. Takehara E, Mandai S*, Shikuma S, Akita W, Chiga M, Mori T, Oda T, Kuwahara M, Uchida S.. Post-infectious Proliferative Glomerulonephritis with Monoclonal Immunoglobulin G Deposits Associated with Complement Factor H Mutation. Intern. Med.. 2017.04; 56 (7): 811-817. ( PubMed, DOI )

  15. Mandai S, Mori T, Sohara E, Rai T, Uchida S.. Generation of Hypertension-Associated STK39 Polymorphism Knockin Cell Lines With the Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 System. Hypertension. 2015.12; 66 (6): 1199-1206. ( PubMed, DOI )

  16. Mandai S*, Kasagi Y, Kusaka K, Shikuma S, Akita W, Kuwahara M.. Helicobacter cinaedi kidney cyst infection and bacteremia in a patient with autosomal dominant polycystic kidney disease J Infect Chemother. 2014.11; 20 (11): 732-734. ( PubMed, DOI )

  17. Mandai S*, Kuwahara M, Kasagi Y, Kusaka K, Tanaka T, Shikuma S, Akita W, Sasaki S.. Lower serum sodium level predicts higher risk of infection-related hospitalization in maintenance hemodialysis patients: an observational cohort study BMC Nephrol. 2013.12; 14 276. ( PubMed, DOI )

  18. Mandai S*, Kanda E, Arai Y, Hirasawa S, Hirai T, Aki S, Inaba N, Aoyagi M, Tanaka H, Ikeda T, Tamura T, Sasaki S.. Anti-centromere antibody is an independent risk factor for chronic kidney disease in patients with primary biliary cirrhosis Clin Exp Nephrol. 2013.06; 17 (3): 405-410. ( PubMed, DOI )

  19. Mandai S*, Aoyagi M, Nagahama K, Arai Y, Hirasawa S, Aki S, Inaba N, Tanaka H, Tsuura Y, Tamura T, Sasaki S.. Post-staphylococcal infection Henoch-Schönlein purpura nephritis: a case report and review of the literature Ren Fail. 2013.07; 35 (6): 869-874. ( PubMed, DOI )

  20. Mandai S*, Arai Y, Hirasawa S, Hirai T, Aki S, Inaba N, Aoyagi M, Tanaka H, Tamura T, Sasaki S.. Anti-centromere antibody-positive subjects presenting with hypertensive emergency and renal dysfunction in the absence of skin manifestations: a variant of systemic sclerosis or a novel entity? Intern Med. 2012.06; 51 (12): 1567-1572. ( PubMed )

  21. Mandai S*, Nagahama K, Tsuura Y, Hirai T, Yoshioka W, Takahashi D, Aki S, Aoyagi M, Tanaka H, Tamura T.. Recovery of renal function in a dialysis-dependent patient with microscopic polyangiitis and both myeloperoxidase anti-neutrophil cytoplasmic antibodies and anti-glomerular basement membrane antibodies Intern Med. 2011.08; 50 (15): 1599-1603. ( PubMed )

  22. Nakano Y, Susa K, Yanagi T, Hiraoka Y, Suzuki T, Mori T, Ando F, Mandai S, Fujiki T, Rai T, Uchida S, Sohara E.. Generation of NPHP1 knockout human pluripotent stem cells by a practical biallelic gene deletion strategy using CRISPR/Cas9 and ssODN. In Vitro Cell Dev Biol Anim. 2022.02; 58 (2): 85-95. ( PubMed, DOI )

  23. Fujimaru T, Kawanishi K, Mori T, Mishima E, Sekine A, Chiga M, Mizui M, Sato N, Yanagita M, Ooki Y, Nagahama K, Ohnuki Y, Hamano N, Watanabe S, Mochizuki T, Nagatsuji K, Tanaka K, Tsukamoto T, Tsushima H, Shimamoto M, Tsuji T, Kuyama T, Kawamoto S, Maki K, Katsuma A, Oishi M, Yamamoto K, Mandai S, Kikuchi H, Ando F, Mori Y, Susa K, Iimori S, Naito S, Rai T, Hoshino J, Ubara Y, Miyazaki M, Nagata M, Uchida S, Sohara E. Genetic Background and Clinicopathologic Features of Adult-onset Nephronophthisis. Kidney international reports. 2021.05; 6 (5): 1346-1354. ( PubMed, DOI )

  24. Takahashi N, Kikuchi H, Usui A, Furusho T, Fujimaru T, Fujiki T, Yanagi T, Matsuura Y, Asano K, Yamamoto K, Ando F, Susa K, Mandai S, Mori T, Rai T, Uchida S, Arita M, Sohara E. Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD<sub>2</sub> in the kidney. Clinical and experimental nephrology. 2021.02; ( PubMed, DOI )

  25. Mori T, Chiga M, Fujimaru T, Kawamoto R, Mandai S, Nanamatsu A, Nomura N, Ando F, Susa K, Sohara E, Rai T, Uchida S.. Phenotypic differences of mutation-negative cases in Gitelman syndrome clinically diagnosed in adulthood HUMAN MUTATION. 2020.12; 42 (3): 300-309. ( PubMed, DOI )

  26. Arai Y, Asano K, Mandai S, Ando F, Susa K, Mori T, Nomura N, Rai T, Tanaka M, Uchida S, Sohara E.. WNK1-TAK1 signaling suppresses lipopolysaccharide-induced cytokine production and classical activation in macrophages BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2020.12; 533 (4): 1290-1297. ( PubMed, DOI )

  27. Sekine A, Hoshino J, Fujimaru T, Suwabe T, Mizuno H, Kawada M, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Mandai S, Chiga M, Kikuchi H, Ando F, Mori T, Sohara E, Uchida S, Sawa N, Takaichi K, Ubara Y. Genetics May Predict Effectiveness of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease. American journal of nephrology. 2020.08; 1-7. ( PubMed, DOI )

  28. Furusho T, Sohara E, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Zeniya M, Mori T, Susa K, Isobe K, Nomura N, Yamamoto K, Okado T, Rai T, Uchida S.. Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease. Kidney Int.. 2020.04; 97 (4): 713-727. ( PubMed, DOI )

  29. Sekine A, Fujimaru T, Hoshino J, Suwabe T, Oguro M, Mizuno H, Kawada M, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Mandai S, Chiga M, Kikuchi H, Ando F, Mori T, Sohara E, Uchida S, Sawa N, Takaichi K, Ubara Y.. Genotype-Clinical Correlations in Polycystic Kidney Disease with No Apparent Family History. Am. J. Nephrol.. 2019; 49 (3): 233-240. ( PubMed, DOI )

  30. Kikuchi H, Sasaki E, Nomura N, Mori T, Minamishima YA, Yoshizaki Y, Takahashi N, Furusho T, Arai Y, Mandai S, Yamashita T, Ando F, Maejima Y, Isobe K, Okado T, Rai T, Uchida S, Sohara E. Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease. Kidney International. 2018.11; ( PubMed, DOI )

  31. Fujimaru T, Mori T, Sekine A, Mandai S, Chiga M, Kikuchi H, Ando F, Mori Y, Nomura N, Iimori S, Naito S, Okado T, Rai T, Hoshino J, Ubara Y, Uchida S, Sohara E.. Kidney enlargement and multiple liver cyst formation implicate mutations in PKD1/2 in adult sporadic polycystic kidney disease CLINICAL GENETICS. 2018.07; 94 (1): 125-131. ( DOI )

  32. Nomura N, Shoda W, Wang Y, Mandai S, Furusho T, Takahashi D, Zeniya M, Sohara E, Rai T, Uchida S.. Role of ClC-K and barttin in low potassium-induced sodium chloride cotransporter activation and hypertension in mouse kidney BIOSCIENCE REPORTS. 2018.02; 38 (1): ( PubMed, DOI )

  33. Ito Y, Sekine A, Takada D, Yabuuchi J, Kogure Y, Ueno T, Sumida K, Yamanouchi M, Hayami N, Suwabe T, Hoshino J, Sawa N, Takaichi K, Kinowaki K, Fujii T, Ohashi K, Kikuchi H, Mandai S, Chiga M, Mori T, Sohara E, Uchida S, Ubara Y.. Renal histology and MRI findings in a 37-year-old Japanese patient with autosomal recessive polycystic kidney disease CLINICAL NEPHROLOGY. 2017.11; 88 (5): 292-298. ( PubMed, DOI )

  34. Zeniya M, Mori T, Yui N, Nomura N, Mandai S, Isobe K, Chiga M, Sohara E, Rai T, Uchida S.. The proteasome inhibitor bortezomib attenuates renal fibrosis in mice via the suppression of TGF-beta 1 SCIENTIFIC REPORTS. 2017.10; 7 (1): 13086. ( PubMed, DOI )

  35. Yoshizaki Y, Mori T, Ishigami-Yuasa M, Kikuchi E, Takahashi D, Zeniya M, Nomura N, Mori Y, Araki Y, Ando F, Mandai S, Kasagi Y, Arai Y, Sasaki E, Yoshida S, Kagechika H, Rai T, Uchida S, Sohara E.. Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy SCIENTIFIC REPORTS. 2017.06; 7 (1): 3945. ( PubMed, DOI )

  36. Sasaki E, Susa K, Mori T, Isobe K, Araki Y, Inoue Y, Yoshizaki Y, Ando F, Mori Y, Mandai S, Zeniya M, Takahashi D, Nomura N, Rai T, Uchida S, Sohara E.. KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3 MOLECULAR AND CELLULAR BIOLOGY. 2017.04; 37 (7): ( PubMed, DOI )

  37. Arai Y, Takahashi D, Asano K, Tanaka M, Oda M, Ko SBH, Ko MSH, Mandai S, Nomura N, Rai T, Uchida S, Sohara E. Salt suppresses IFNγ inducible chemokines through the IFNγ-JAK1-STAT1 signaling pathway in proximal tubular cells. Scientific reports. 2017.04; 7 46580. ( PubMed, DOI )

  38. Mori T, Hosomichi K, Chiga M, Mandai S, Nakaoka H, Sohara E, Okado T, Rai T, Sasaki S, Inoue I, Uchida S.. Comprehensive genetic testing approach for major inherited kidney diseases, using next-generation sequencing with a custom panel CLINICAL AND EXPERIMENTAL NEPHROLOGY. 2017.02; 21 (1): 63-75. ( PubMed, DOI )

  39. Kikuchi H, Kanda E, Mandai S, Akazawa M, Iimori S, Oi K, Naito S, Noda Y, Toda T, Tamura T, Sasaki S, Sohara E, Okado T, Rai T, Uchida S.. Combination of low body mass index and serum albumin level is associated with chronic kidney disease progression: the chronic kidney disease-research of outcomes in treatment and epidemiology (CKD-ROUTE) study CLINICAL AND EXPERIMENTAL NEPHROLOGY. 2017.02; 21 (1): 55-62. ( PubMed, DOI )

  40. Kuwahara M, Mandai S, Kasagi Y, Kusaka K, Tanaka T, Shikuma S, Akita W.. Responsiveness to erythropoiesis-stimulating agents and renal survival in patients with chronic kidney disease. Clin Exp Nephrol. 2015.08; 19 (4): 598-605. ( PubMed, DOI )

  41. Kuwahara M, Hasumi S, Mandai S, Tanaka T, Shikuma S, Akita W, Mori Y, Sasaki S.. Effects of three kinds of erythropoiesis-stimulating agents on renal anemia in Japanese non-dialysis chronic kidney disease patients. Clin Exp Nephrol. 2014.10; 18 (5): 755-762. ( PubMed, DOI )

  42. Kuwahara M, Hasumi S, Mandai S, Tanaka T, Shikuma S, Akita W, Mori Y, Sasaki S.. Rate of ankle-brachial index decline predicts cardiovascular mortality in hemodialysis patients. Ther Apher Dial. 2014.02; 18 (1): 9-18. ( PubMed, DOI )

  43. Ohta E, Akazawa M, Noda Y, Mandai S, Naito S, Ohta A, Sohara E, Okado T, Rai T, Uchida S, Sasaki S.. Severe hyperparathyroidism in a pre-dialysis chronic kidney disease patient treated with a very low protein diet. J Bone Miner Metab. 2012.03; 30 (2): 238-242. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Shintaro Mandai, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Shinichi Uchida, Kiyohide Fushimi, Tatemitsu Rai. Burden of Kidney Disease on Discrepancy between Reasons for Admission and Death:A Nationwide Cohort Study of Japanese Adults. 2021.06.20

  2. Shintaro Mandai. WNK1 kinase: a novel potential player in skeletal muscle hypertrophy and sarcopenia induced by chronic kidney disease. The 43th Annual Meeting of the Molecular Biology Society of Japan (MBSJ2020) 2020.12.03 web

  3. Mandai S, Kanda E, Iimori S, Naito S, Sohara E, Okado T, Sasaki S, Rai T, Uchida S. Association of Serum Chloride Level with Mortality and Cardiovascular Events in Chronic Kidney Disease: The CKD-ROUTE Study. The 48th Annual Meeting of American Society of Nephrology 2015.11.05 San Diego

  4. Mandai S, Mori T, Sohara E, Rai T, Uchida S. Generation of Hypertension-Associated STK39 Polymorphism Knockin Cell Lines with the CRISPR/Cas9 System. The 48th Annual Meeting of American Society of Nephrology 2015.11.05 San Diego

Others 【 display / non-display

  • 【Press release】Urgent dialysis during hospitalization for surgery predicts poor outcomes,2022.09

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