Personnel Information

写真a

SHIMIZU Kazuhide


Job title

Assistant Professor
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Department of Functional Neurosurgery, 2018.03, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Doctor's Course, 2018.03, Completed

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Degree 【 display / non-display 】

  • Ph.D, Tokyo Medical and Dental University

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Campus Career 【 display / non-display 】

  • 2014.04
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurosurgery， Graduate Student
  • 2017.06
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    2019.09
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Hospital Departments， Department of Neurology, Neurosurgery,Psychiatry and Anesthesiology， Neurosurgery， Assistant Professor
  • 2019.11
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    2022.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Cognitive and Behavioral Medicine， Department of Neurosurgery， Visiting Lecturer
  • 2022.04
    -
    2022.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Endovascular Surgery， Assistant Professor
  • 2022.10
    -
    2023.03
    Tokyo Medical and Dental University， Tokyo Medical and Dental University， Division of Clinical Medicine， Department of Neurology, Neurosurgery, Psychiatry, and Anesthesiology， Neurosurgery， Assistant Professor
  • 2023.04
    -
    2024.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Cognitive and Behavioral Medicine， Neurosurgery， Assistant Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo， -， Graduate Schools， Cognitive and Behavioral Medicine， Department of Neurosurgery， Assistant Professor

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External Career 【 display / non-display 】

  • 2014.04
    -
    2017.05
    Tokyo Medical and Dental University Hospital, Department of Neurosurgery,
  • 2017.06
    -
    2019.09
    Tokyo Medical and Dental University Hospital, Department of Neurosurgery, Assistant Professor
  • 2019.09
    -
    2022.03
    Massachusetts General Hospital, Department of Neurosurgery, Postdoctoral research fellow
  • 2019.10
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    2022.03
    Massachusetts General Hospital, Harvard Medical School, Department of Neurosurgery, Post-doctoral Research Fellow
  • 2022.04
    -
    2022.06
    Tokyo Medical and Dental University Hospital, Department of Endovascular Surgery, Assistant Professor
  • 2022.07
    -
    2024.09
    Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Department of Functional Neurosurgery,, Assistant Professor
  • 2024.10
    -
    Now
    Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Department of Functional Neurosurgery, Assistant Professor

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Academic Activity 【 display / non-display 】

  • 2026.01
    -
    Now
    Springer Nature Reviewing Editor
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Research Areas 【 display / non-display 】

  • Biomedical engineering

  • Neurosurgery

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Research Theme 【 display / non-display 】

  • Intraoperative real-time non-invasive cerebral blood flow analysis by Laser Speckle Contrast Imaging, 2021.11 - 2026.03

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Published Papers & Misc 【 display / non-display 】

  1. Kazuhide Shimizu, Masayuki Nitta, Takashi Komori, Takashi Maruyama, Takayuki Yasuda, Yu Fujii, Ken Masamune, Takakazu Kawamata, Taketoshi Maehara, Yoshihiro Muragaki. Intraoperative Photodynamic Diagnosis Using Talaporfin Sodium Simultaneously Applied for Photodynamic Therapy against Malignant Glioma: A Prospective Clinical Study. Frontiers in Neurology. 2018.01; 9 24. ( PubMed, DOI )

  2. Educational Impact of an Annotation System Integrated with an Exoscope for Cerebral Aneurysm Surgery: Case Description. 2025; 136 165-169. ( PubMed, DOI )

  3. Yamamura T, Tamura K, Kobayashi D, Inaji M, Toyama Y, Wakimoto H, Kiyokawa J, Hara S, Tanaka Y, Nariai T, Shimizu K, Ishii K, Maehara T. Loss of methylthioadenosine phosphorylase immunoreactivity correlates with poor prognosis and elevated uptake of (11)C-methionine in IDH-mutant astrocytoma. Journal of neuro-oncology. 2024.04; 168 (2): 355-365. ( PubMed, DOI )

  4. Kaneko S, Inaji M, Shimizu K, Orihara A, Hashimoto Fujimoto S, Maehara T. Clinical utility and safety of a trapezoid-shaped electrode placement for evaluating the mesio-basal temporal lobe during epilepsy surgery. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2024.03; 121 28-33. ( PubMed, DOI )

  5. Arai Y, Inaji M, Shimizu K, Kondo S, Hashimoto-Fujimoto S, Kiyokawa J, Kawano Y, Yamamoto S, Maehara T. Long-term efficacy and safety of perampanel as an add-on therapy in patients with epilepsy. Epilepsy research. 2024.02; 200 107307. ( PubMed, DOI )

  6. Exomap1 mouse: A transgenic model for in vivo studies of exosome biology. 2023.12; 2 ( PubMed, DOI )

  7. Shimizu K, Kahramanian A, Jabbar MADA, Turna Demir F, Gokyer D, Uthamacumaran A, Rajan A, Saad MA, Gorham J, Wakimoto H, Martuza RL, Rabkin SD, Hasan T, Wakimoto H. Photodynamic augmentation of oncolytic virus therapy for central nervous system malignancies. Cancer letters. 2023.08; 572 216363. ( PubMed, DOI )

  8. Sabari JK, Velcheti V, Shimizu K, Strickland MR, Heist RS, Singh M, Nayyar N, Giobbie-Hurder A, Digumarthy SR, Gainor JF, Rajan AP, Nieblas-Bedolla E, Burns AC, Hallin J, Olson P, Christensen JG, Kurz SC, Brastianos PK, Wakimoto H. Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRASG12C-Mutant Non-Small Cell Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2022.08; 28 (15): 3318-3328. ( PubMed, DOI )

  9. Shimizu K, Tamura K, Hara S, Inaji M, Tanaka Y, Kobayashi D, Sugawara T, Wakimoto H, Nariai T, Ishii K, Sakuma I, Maehara T. Correlation of Intraoperative 5-ALA-Induced Fluorescence Intensity and Preoperative (11)C-Methionine PET Uptake in Glioma Surgery. Cancers. 2022.03; 14 (6): ( PubMed, DOI )

  10. Kobayashi T, Nitta M, Shimizu K, Saito T, Tsuzuki S, Fukui A, Koriyama S, Kuwano A, Komori T, Masui K, Maehara T, Kawamata T, Muragaki Y. Therapeutic Options for Recurrent Glioblastoma-Efficacy of Talaporfin Sodium Mediated Photodynamic Therapy. Pharmaceutics. 2022.02; 14 (2): ( PubMed, DOI )

  11. Anatomy-oriented stereotactic approach to cerebrospinal fluid collection in mice. 2022.01; 1774 147706. ( PubMed, DOI )

  12. Orihara A, Hara K, Hara S, Shimizu K, Inaji M, Hashimoto S, Maehara T. Effects of sevoflurane anesthesia on intraoperative high-frequency oscillations in patients with temporal lobe epilepsy. Seizure. 2020.11; 82 44-49. ( PubMed, DOI )

  13. Shimizu K, Hara S, Hori M, Tanaka Y, Maehara T, Aoki S, Tazawa T, Nariai T. Transient Global Amnesia: A Diffusion and Perfusion MRI study. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2020.11; 30 (6): 828-832. ( PubMed, DOI )

  14. Shimizu Kazuo, Shimizu Kazuhide, Okamura Ritsuko, Igarashi Takehito, Nagaoka Ryuta, Sanada Marie, Sugitani Iwao, Fukumori Tatsuya, Yamada Tetsu. 甲状腺・副甲状腺疾患に対する吊り上げ法を用いた内視鏡補助下甲状腺手術(VANS)　VANS法に関するA to Z(Video-assisted neck surgery(VANS) using a gasless lifting procedure for thyroid and parathyroid diseases: "The VANS method from A to Z") Surgery Today. 2020.10; 50 (10): 1126-1137. ( ichushi )

  15. Hara S, Shimizu K, Nariai T, Kishino M, Kudo T, Umemoto T, Inaji M, Maehara T. De Novo Renal Artery Stenosis Developed in Initially Normal Renal Arteries during the Long-Term Follow-Up of Patients with Moyamoya Disease. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 2020.08; 29 (8): 104786. ( PubMed, DOI )

  16. Shimizu K, Shimizu K, Okamura R, Igarashi T, Nagaoka R, Sanada M, Sugitani I, Fukumori T, Yamada T. Video-assisted neck surgery (VANS) using a gasless lifting procedure for thyroid and parathyroid diseases: "The VANS method from A to Z". Surgery today. 2019.11; 50 (10): 1126-1137. ( PubMed, DOI )

  17. Takahashi S, Shimizu K, Inaji M, Hashimoto S, Yamamoto S, Maehara T. Effectiveness of perampanel as a first add-on antiepileptic drug for the treatment of partial epilepsy. Epilepsy & behavior : E&B. 2019.11; 100 (Pt A): 106492. ( PubMed, DOI )

  18. Comparative analysis of 5-ALA-induced fluorescence intensity and 11C-Methionine PET uptake in glioma surgery 2019; 11070 ( DOI )

  19. Ohnaka K, Shimizu K, Kobayashi D, Inaji M, Maehara T. Dysembryoplastic Neuroepithelial Tumor with Extension to the Basal Cistern: A Case Report Epilepsy & Seizure. 2018.11; ( DOI )

  20. Ohnaka Keisuke, Shimizu Kazuhide, Kobayashi Daisuke, Inaji Motoki, Maehara Taketoshi. 基底槽に伸展した胚芽異形成性神経上皮腫瘍　1症例報告(Dysembryoplastic Neuroepithelial Tumor with Extension to the Basal Cistern: A Case Report) Epilepsy & Seizure. 2018; 10 (1): 87-94. ( ichushi )

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Conference Activities & Talks 【 display / non-display 】

  1. Intraoperative 5-ALA Fluorescence Visibility in Glioma Surgery Using Exoscope: Comparison with Microscope and Implications for Automated Detection. 2025.11.21

  2. Kazuhide Shimizu, Andranik Kahramanian, Taketoshi Maehara, Hiroaki Wakimoto. Photodynamic Oncolytic Virus Therapy for Central Nervous System Malignancies. 28th Society for Neuro-Oncology Annual Meeting 2023.11.17

  3. Kazuhide Shimizu, Yoji Tanaka, Daisu Abe, Motoki Inaji, Taketoshi Maehara. Intraoperative Evaluation of Cerebral Blood Flow Using Laser Speckle Contrast Imaging (LSCI). 2023 Joint Neurosurgical Convention 2023.02.07

  4. Kazuhide Shimizu, Andranik Kahramanian, Hiroaki Wakimoto. Photodynamic oncolytic virotherapy incorporating genetically engineeredphotosensitizer KillerRed for the treatment of central nervous system malignancies. The 26th Society for Neuro-Oncology Annual Meeting 2021.11.18

  5. 1. Shimizu K., Inaji M., Tanaka Y., Tamura K., Sugawara T., Ishii K., Nariai T., Maehara T.. .: Comparative analysis of 5-ALA-induced fluorescence intensity and 11C-Methionine PET uptake in glioma surgery. 第34回日本脳神経外科国際学会フォーラム 2019.07.26

  6. Kazuhide Shimizu, Kaoru Tamura, Takashi Sugawara, Motoki Inaji, Yoji Tanaka, Tadashi Nariai, Taketoshi Maehara. Intraoperative 5-ALA-induced fluorescence intensity as an indicator for 11C-Methionine Positron Emission Tomography uptake in astrocytomas. The 34th Japan Neurosurgical English Forum (JNEF) 2019.07.26

  7. 1. Shimizu K., Inaji M., Tanaka Y., Tamura K., Sugawara T., Ishii K.,Nariai T., Maehara T.. Comparative analysis of 5-ALA-induced fluorescence intensity and 11C-Methionine PET uptake in glioma surgery. 17th International Photodynamic Association World Congress 2019.06.30

  8. Kazuhide Shimizu, Motoki Inaji, Yoji Tanaka, Kaoru Tamura, Takashi Sugawara, Kenji Ishii, Tadashi Nariai, Taketoshi Maehara. Comparative analysis of 5-ALA-induced fluorescence intensity and 11C-Methionine PET uptake in glioma surgery. 17th International Photodynamic Association World Congress 2019.06.30

  9. Shimizu K, Hara S, Tazawa T, Hori M, Tanaka Y, Maehara T, Aoki S, Nariai T. Neurite orientation dispersion and density imaging (NODDI) study in patients with transient global amnesia (TGA). Neuroscience 2017 2017.11.15

  10. Kazuhide Shimizu, Shoko Hara, Toshiaki Tazawa, Masaaki Hori, Yoji Tanaka, Taketoshi Maehara, Shigeki Aoki, Tadashi Nariai. Neurite orientation dispersion and density imaging (NODDI) study in patients with transient global amnesia (TGA). Neuroscience 2017 2017.11.15

  11. SHIMIZU Kazuhide, TANAKA Yoji, KOBAYASHI Daisuke, AKASHI Takumi, MAEHARA Taketoshi. Ki-67 Labelling Index Decreased Post Gamma Knife Radiosurgery in a Recurrent Pituitary Adenoma. The 4th Biennial Congress of the Asian Leksell Gamma Knife Society 2015.02.21

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Social Contribution 【 display / non-display 】

  • Springer Nature Reviewing Editor，2026.01.18 - Now

  • The 6th Asian Congress of Microvascular Decompression Surgery, Chair (Poster I, Hemifacial Spasm),，2025.09.20

  • The 6th Asian Congress of Microvascular Decompression Surgery, Secretary-General，2025.09.19 - 2025.09.20

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