論文・総説 - 梅澤　佳央

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  1. Nogami, A; Amemiya, HJ; Fujiwara, H; Umezawa, Y; Tohda, S; Nagao, T. Targeting USP14/UCHL5: A Breakthrough Approach to Overcoming Treatment-Resistant FLT3-ITD-Positive AML INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024.10; 25 (19): ( PubMed, DOI )

  2. Satoshi Kaito, Yuho Najima, Daichi Sadato, Chizuko Hirama, Yuya Kishida, Akihito Nagata, Tatsuya Konishi, Yuta Yamada, Shuhei Kurosawa, Kota Yoshifuji, Shuichi Shirane, Naoki Shingai, Takashi Toya, Hiroaki Shimizu, Kyoko Haraguchi, Takeshi Kobayashi, Hironori Harada, Yoshiki Okuyama, Yuka Harada, Noriko Doki. Azacitidine and gemtuzumab ozogamicin as post-transplant maintenance therapy for high-risk hematologic malignancies. Bone Marrow Transplant. 2024.08; 59 (8): 1169-1175. ( PubMed, DOI )

  3. Akiyama H, Kantarjian H, Jabbour E, Issa G, Haddad FG, Short NJ, Hu S, Ishizawa J, Andreeff M, Sasaki K. Outcome of 3q26.2/MECOM rearrangements in chronic myeloid leukemia. International journal of hematology. 2024.08; 120 (2): 203-211. ( PubMed, DOI )

  4. Megumi Akiyama, Masashi Kanayama, Yoshihiro Umezawa, Toshikage Nagao, Yuta Izumi, Masahide Yamamoto, Toshiaki Ohteki. An early regulatory mechanism of hyperinflammation by restricting monocyte contribution. Front Immunol. 2024.07; 15 1398153. ( PubMed, DOI )

  5. Pourebrahim R, Montoya RH, Akiyama H, Ostermann L, Khazaei S, Muftuoglu M, Baran N, Zhao R, Lesluyes T, Liu B, Khoury JD, Gagea M, Van Loo P, Andreeff M. Age-specific induction of mutant p53 drives clonal hematopoiesis and acute myeloid leukemia in adult mice. Cell reports. Medicine. 2024.05; 5 (5): 101558. ( PubMed, DOI )

  6. Umezawa Y, Yoshifuji K, Tanaka K, Nogami A, Nagano K, Tsuji A, Nagao T, Yamamoto M, Kajiwara M, Tohda S, Mori T. Impact of BK polyomavirus viremia on the outcomes of allogeneic hematopoietic stem cell transplantation. Annals of hematology. 2024.05; 103 (5): 1737-1744. ( PubMed, DOI )

  7. Akiyama H, Zhao R, Ostermann LB, Li Z, Tcheng M, Yazdani SJ, Moayed A, Pryor ML 2nd, Slngh S, Baran N, Ayoub E, Nishida Y, Mak PY, Ruvolo VR, Carter BZ, Schimmer AD, Andreeff M, Ishizawa J. Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia. Leukemia. 2024.04; 38 (4): 729-740. ( PubMed, DOI )

  8. Asuka Kono, Manabu Wakamatsu, Yoshihiro Umezawa, Hideki Muramatsu, Hiroki Fujiwara, Dan Tomomasa, Kento Inoue, Keiichiro Hattori, Tetsuo Mitsui, Hidetoshi Takada, Yoshiyuki Minegishi, Yoshiyuki Takahashi, Masahide Yamamoto, Takehiko Mori, Hirokazu Kanegane. Successful treatment of DOCK8 deficiency by allogeneic hematopoietic cell transplantation from alternative donors. Int J Hematol. 2023.10; 118 (4): 519-525. ( PubMed, DOI )

  9. Tomoyasu Jo, Satoshi Yoshihara, Yoshiki Okuyama, Keiko Fujii, Tomoko Henzan, Kaoru Kahata, Rie Yamazaki, Wataru Takeda, Yoshihiro Umezawa, Kentaro Fukushima, Takashi Ashida, Minami Yamada-Fujiwara, Ryo Hanajiri, Noboru Yonetani, Yuma Tada, Yuji Shimura, Hidekazu Nishikii, Norio Shiba, Naoya Mimura, Jun Ando, Takayuki Sato, Yasuhiro Nakashima, Junko Ikemoto, Keita Iwaki, Shin-Ichiro Fujiwara, Masaki Ri, Tokiko Nagamura-Inoue, Ryuji Tanosaki, Yasuyuki Arai. Risk factors for CAR-T cell manufacturing failure among DLBCL patients: A nationwide survey in Japan. Br J Haematol. 2023.07; 202 (2): 256-266. ( PubMed, DOI )

  10. Akiyama H, Carter BZ, Andreeff M, Ishizawa J. Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia. Cells. 2023.04; 12 (8): ( PubMed, DOI )

  11. Yoshihiro Umezawa, Koji Sasaki. Dose optimization of tyrosine kinase inhibitor therapy in chronic myeloid leukemia. Int J Hematol. 2023.01; 117 (1): 24-29. ( PubMed, DOI )

  12. Kimura Shunichi, Shimizu Hiroaki, Miyazaki Takuya, Sakurai Masatoshi, Tanoue Susumu, Kayamori Kensuke, Ohwada Chikako, Yoshimura Kazuki, Nakasone Hideki, Ohashi Takuma, Shono Katsuhiro, Tachibana Takayoshi, Hatano Kaoru, Okada Keigo, Kimura Yuta, Seo Sachiko, Doki Noriko, Tanaka Masatsugu, Hatta Yoshihiro, Takahashi Satoshi, Kanda Yoshinobu. Impact of standard-dose dipeptidyl peptidase-4 inhibitors on the incidence of graft-versus-host disease after allogeneic hematopoietic cell transplantation BONE MARROW TRANSPLANTATION. 2022.12; ( PubMed, DOI )

  13. Satoru Aoyama, Shunichiro Yasuda, Huixin Li, Daisuke Watanabe, Yoshihiro Umezawa, Keigo Okada, Ayako Nogami, Osamu Miura, Norihiko Kawamata. A novel chimeric antigen receptor (CAR) system using an exogenous protease, in which activation of T cells is controlled by expression patterns of cell‑surface proteins on target cells. International Journal of Molecular Medicine. 2022.04; 49 (4): ( PubMed, DOI )

  14. Aya Usami, Kota Yokoyama, Junichi Tsuchiya, Yoshihiro Umezawa, Kazuma Toda, Ukihide Tateishi, Ryoichi Yoshimura. F]FDG Avidity and Low EOB Uptake Proportional to the Irradiation Dose. Diagnostics (Basel). 2022.02; 12 (2): ( PubMed, DOI )

  15. Shunichiro Yasuda, Satoru Aoyama, Ryoto Yoshimoto, Huixin Li, Daisuke Watanabe, Hiroki Akiyama, Kouhei Yamamoto, Takeo Fujiwara, Yuho Najima, Noriko Doki, Emiko Sakaida, Yoko Edahiro, Misa Imai, Marito Araki, Norio Komatsu, Osamu Miura, Norihiko Kawamata. MPL overexpression induces a high level of mutant-CALR/MPL complex: a novel mechanism of ruxolitinib resistance in myeloproliferative neoplasms with CALR mutations. Int J Hematol. 2021.10; 114 (4): 424-440. ( PubMed, DOI )

  16. Mai Kuboki, Yoshihiro Umezawa, Yotaro Motomura, Keigo Okada, Ayako Nogami, Toshikage Nagao, Osamu Miura, Masahide Yamamoto. Severe Motor Weakness Due to Disturbance in Peripheral Nerves Following Tisagenlecleucel Treatment. In Vivo. 2021.09; 35 (6): 3407-3411. ( PubMed, DOI )

  17. Shunichiro Yasuda, Yuho Najima, Tatsuya Konishi, Yuta Yamada, Akihito Nagata, Toshiaki Takezaki, Satoshi Kaito, Shuhei Kurosawa, Masahiro Sakaguchi, Kaito Harada, Naoki Shingai, Kosuke Yoshioka, Kyoko Inamoto, Junichi Mukae, Takashi Toya, Aiko Igarashi, Hiroaki Shimizu, Takeshi Kobayashi, Kazuhiko Kakihana, Hisashi Sakamaki, Norihiko Kawamata, Kazuteru Ohashi, Noriko Doki. Outcome of allogeneic hematopoietic stem cell transplantation for T-cell lymphoblastic leukemia/lymphoma: A single-center study. Leuk Res. 2021.09; 108 106627. ( PubMed, DOI )

  18. Nishida Y, Zhao R, Heese LE, Akiyama H, Patel S, Jaeger AM, Jacamo RO, Kojima K, Ma MCJ, Ruvolo VR, Chachad D, Devine W, Lindquist S, Davis RE, Porco JA Jr, Whitesell L, Andreeff M, Ishizawa J. Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML. Leukemia. 2021.09; 35 (9): 2469-2481. ( PubMed, DOI )

  19. Konishi Tatsuya, Kusakabe Shinsuke, Hino Akihisa, Inamoto Kyoko, Yoshifuji Kota, Kiridoshi Yuko, Takeshita Kozue, Sasajima Satoshi, Toya Takashi, Igarashi Aiko, Najima Yuho, Kobayashi Takeshi, Doki Noriko, Motooka Daisuke, Nakamura Shota, Suyama Masahiro, Suda Wataru, Shiota Atsushi, Atarashi Koji, Hattori Masahira, Honda Kenya, Yokota Takafumi, Ohashi Kazuteru, Shibayama Hirohiko, Fukushima Kentaro, Kakihana Kazuhiko. Low diversity of gut microbiota in the early phase of post-bone marrow transplantation increases the risk of chronic graft-versus-host disease BONE MARROW TRANSPLANTATION. 2021.07; 56 (7): 1728-1731. ( DOI )

  20. Kota Yoshifuji, Takashi Toya, Noriyo Yanagawa, Fumikazu Sakai, Akihito Nagata, Noritaka Sekiya, Kazuteru Ohashi, Noriko Doki. CT classification of acute myeloid leukemia with pulmonary infiltration Japanese Journal of Radiology. 2021.06; 39 (11): 1049-1058. ( PubMed, DOI )

  21. 田畑 真梨子, 佐藤 悠佑, 木暮 泰寛, McClure Marni B., 斎藤 優樹, 新垣 清登, 吉藤 康太, 古屋 淳史, 河野 隆志, 白石 友一, 久米 春喜, 片岡 圭亮. がん分子標的治療薬・がん免疫治療薬への抵抗性に関わる分子機構とその克服　遺伝性淡明細胞型腎細胞癌における腫瘍内または腫瘍間の遺伝的、免疫的不均一性 日本癌学会総会記事. 2020.10; 79回 S4-3. ( 医中誌 )

  22. 古屋 淳史, 斎藤 優樹, 亀田 拓郎, 木暮 泰寛, McClure Marni B., 新垣 清登, 吉藤 康太, 田畑 真梨子, 下田 和哉, 片岡 圭亮. がんの一細胞生物学　マルチオミクス単一細胞解析によるHTLV-1感染状態およびATLにおける細胞動態の網羅的解明 日本癌学会総会記事. 2020.10; 79回 S12-3. ( 医中誌 )

  23. Kota Yoshifuji, Yoshihiro Umezawa, Ayako Ichikawa, Ken Watanabe, Osamu Miura, Masahide Yamamoto. Methotrexate-associated Classical Hodgkin Lymphoma Shows Distinct Clinicopathological Features but Comparable Clinical Outcomes With Sporadic Cases. In Vivo. 2019.09; 33 (5): 1599-1604. ( PubMed, DOI )

  24. Masahide Yamamoto, Keisuke Tanaka, Yoshihiro Umezawa, Toshikage Nagao, Shigeo Toyota, Osamu Miura. Soluble Interleukin-2 Receptor Level at Diagnosis Predicts Prognosis of Patients With Follicular Lymphoma Irrespective of Initial Management Strategy. Anticancer Res.. 2019.09; 39 (9): 5115-5122. ( PubMed, DOI )

  25. Akiyama Hiroki, Umezawa Yoshihiro, Ishida Shinya, Okada Keigo, Nogami Ayako, Miura Osamu. Inhibition of USP9X induces apoptosis in FLT3-ITD-positive AML cells cooperatively by inhibiting the mutant kinase through aggresomal translocation and inducing oxidative stress CANCER LETTERS. 2019; 453 84-94. ( PubMed, DOI )

  26. Ayako Nogami, Keigo Okada, Shinya Ishida, Hiroki Akiyama, Yoshihiro Umezawa, Osamu Miura. Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD-Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway. Transl Oncol. 2018.11; 12 (2): 336-349. ( PubMed, DOI )

  27. Shinya Ishida, Hiroki Akiyama, Yoshihiro Umezawa, Keigo Okada, Ayako Nogami, Gaku Oshikawa, Toshikage Nagao, Osamu Miura. Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2. Oncotarget. 2018.06; 9 (42): 26834-26851. ( PubMed, DOI )

  28. Keigo Okada, Ayako Nogami, Shinya Ishida, Hiroki Akiyama, Cheng Chen, Yoshihiro Umezawa and Osamu Miura. FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway Oncotarget. 2017.12; 9 8870-8886.

  29. Yoshihiro Umezawa, Hiroki Akiyama, Keigo Okada, Shinya Ishida, Ayako Nogami, Gaku Oshikawa, Tetsuya Kurosu, Osamu Miura. Molecular mechanisms for enhancement of stromal cell-derived factor 1-induced chemotaxis by platelet endothelial cell adhesion molecule 1 (PECAM-1). Journal of Biological Chemistry. 2017.12; 292 (48): 19639-19655.

  30. Yoshihiro Umezawa, Tetsuya Kurosu, Hiroki Akiyama, Nang Wu, Ayako Nogami, Toshikage Nagao, Osamu Miusa. Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells. Oncotarget. 2016.06; ( PubMed )

  31. Hiroki Akiyama, Masahide Yamamoto, Chizuko Sakashita, Yoshihiro Umezawa, Tetsuya Kurosu, Naomi Murakami, Osamu Miura. Therapy-related Leukemia with Inv(16)(p13.1q22) and Type D CBFB/MYH11 Developing after Exposure to Irinotecan-containing Chemoradiotherapy. Intern. Med.. 2015; 54 (6): 651-655. ( PubMed, DOI )

  32. Tomoyasu Jo, Tomoko Henzan, Daisuke Tomizawa, Satoru Yoshihara, Kaoru Kahata, Minami Yamada-Fujiwara, Yoshiki Okuyama, Norio Shiba, Keiko Fujii, Yoshihiro Umezawa, Rie Yamazaki, Wataru Takeda, Ryo Hanajiri, Kentaro Fukushima, Naoya Mimura, Junko Ikemoto, Keita Iwaki, Noboru Yonetani, Shin-Ichiro Fujiwara, Masaki Ri, Tokiko Nagamura-Inoue, Ryuji Tanosaki, Yasuyuki Arai. Manufacturing results of tisagenlecleucel for acute lymphoblastic leukemia: a survey by the CAR-T cell therapy taskforce of the Japan Society of Transfusion Medicine and Cell Therapy. Rinsho Ketsueki. 2023; 64 (5): 331-337. ( PubMed, DOI )

  33. 斉藤　真貴子, 梅澤　佳央. AMLに対するIDH1/2阻害薬の臨床効果 血液内科. 2022.12; 85 (6): 803-807.

  34. 田畑 真梨子, 佐藤 悠佑, 木暮 泰寛, Mcclure Marni B., 熊手 祐二, 斎藤 優樹, 新垣 清登, 吉藤 康太, 古屋 淳史, 白石 友一, 久米 春喜, 片岡 圭亮. 遺伝性淡明細胞型腎細胞癌における腫瘍内または腫瘍間の遺伝的、免疫的不均一性 日本泌尿器科学会総会. 2020.12; 108回 804. ( 医中誌 )

  35. 熊谷 拓磨, 土岐 典子, 小林 武, 山田 倫, 比島 恒和, 安達 弘人, 小沼 亮介, 藤田 昌宏, 和田 敦司, 岸田 侑也, 小西 達矢, 永田 啓人, 山田 裕太, 海渡 智史, 吉藤 康太, 迎 純一, 秋山 めぐみ, 稲本 恭子, 遠矢 嵩, 五十嵐 愛子, 名島 悠峰, 垣花 和彦, 坂巻 壽, 大橋 一輝. 同種骨髄移植後空胞性脊髄症を発症した急性リンパ性白血病 臨床血液. 2020.11; 61 (11): 1625-1627. ( 医中誌 )

  36. 内田 智之, 土岐 典子, 岸田 侑也, 永田 啓人, 山田 裕太, 小西 達矢, 海渡 智史, 黒澤 修兵, 吉藤 康太, 白根 脩一, 稲本 恭子, 遠矢 嵩, 五十嵐 愛子, 名島 悠峰, 武藤 秀治, 小林 武, 垣花 和彦, 坂巻 壽, 大橋 一輝. Ph陽性ALLに対する同種造血幹細胞移植後のTKIによる維持療法 臨床血液. 2020.01; 61 (1): 11-19. ( 医中誌 )

  37. 野上　彩子、山本　正英、山本　浩平、伊藤　雅文、梅澤　佳央、東田　修二、三浦　修 、福田　哲也. 汎血球減少の長期経過後に明らかとなった辺縁帯リンパ腫様の骨髄原発リンパ腫 臨床血液. 2020; 61 (10): 1469-1475. ( PubMed, DOI )

  38. 岸田 侑也, 小林 武, 藤田 昌宏, 熊谷 拓磨, 吉藤 康太, 秋山 めぐみ, 稲木 恭子, 遠矢 嵩, 五十嵐 愛子, 名島 悠峰, 土岐 典子, 垣花 和彦, 坂巻 壽, 大橋 一輝. 多種類の栄養欠乏症により汎血球減少と皮膚色素斑を生じ血液悪性疾患との鑑別を要した1例 臨床血液. 2019.10; 60 (10): 1503. ( 医中誌 )

  39. Umezawa Y, Kawamata N. Novel therapies for acute myeloid leukemia based on genomic aberrations. Rinsho Ketsueki. 2019; 60 (6): 594-599. ( PubMed, DOI )

  40. 山下 知子, 梅澤　佳央, 渡邉　健, 福田　哲也, 川又　紀彦, 三浦　修, 山本　正英 . 中枢神経リンパ腫に対するブスルファンを含む前処置を用いた自家造血幹細胞移植の検討 日本造血細胞移植学会誌. 2018.10; 7 (4): 145-151. ( DOI )

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