Personnel Information

写真a

TAZAWA Kento


Job title

Assistant Professor

Mail Address

The inquiry by e-mail is 《here

Graduate School 【 display / non-display

  • Tokyo Medical and Dental University, Doctor's Course, Completed

Campus Career 【 display / non-display

  • 2013.04
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    2016.02
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Pulp Biology and Endodontics, Graduate Student
  • 2013.04
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    2017.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Pulp Biology and Endodontics, Graduate Student
  • 2017.10
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    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Pulp Biology and Endodontics, Visiting Lecturer
  • 2019.04
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    2022.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Pulp Biology and Endodontics, Assistant Professor
  • 2022.04
    -
    2024.09
    Tokyo Medical and Dental University, Tokyo Medical and Dental University, Division of Clinical Dentistry, Department of Conservative Dentistry, Operative Dentistry and Endodontics, Assistant Professor
  • 2022.04
    -
    Now
    Institute of Science Tokyo, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Oral Health Sciences, Pulp Biology and Endodontics, Assistant Professor
  • 2024.10
    -
    Now
    Institute of Science Tokyo, -, Institute of Science Tokyo Hospital, Department of Conservative Dentistry, Operative Dentistry and Endodontics, Assistant Professor

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Published Papers & Misc 【 display / non-display

  1. 福林冬花,田澤建人,八幡祥生. 2型糖尿病が歯髄壊死を認める歯における根尖性歯周炎の大きさ, エンドトキシン濃度, および細菌数に及ぼす影響 ザ・クインテッセンス. 2026.02; 45 (2): 198-200.

  2. Tazawa K, Chen D, Fujimura A, King PD, Sasaki H . Dental pulp lymphatic vessel dynamics during tooth development and pulp stimulation in rodents International Endodontic Journal. 2025.08; 58 (8): 1197-1210. ( PubMed )

  3. Ren C, Tazawa K, Kawashima N, Ohshima R, Okada Y, Wang S, Yu Z, Han P, Ohsugi Y, Katagiri S, Okiji T. Metformin attenuates alveolar bone destruction in mice with apical periodontitis and inhibits pro-inflammatory cytokine synthesis in lipopolysaccharide-stimulated RAW264.7 through the AMPK-mTOR-NF-κB pathway Frontiers in Immunology. 2025.07;

  4. Nyein Chan KO, Sonoko NODA, Yamato OKADA, Kento TAZAWA, Nobuyuki KAWASHIMA and Takashi OKIJI. Biocompatibility and pro-mineralization effects of premixed calcium silicatebased materials on human dental pulp stem cells: An in vitro and in vivo study Dental Materials Journal. 2024.09; 43 (5): 729-737.

  5. Wang S, Kawashima N, Han P, Nara SK, Yu Z, Tazawa K, Fujii M, Kieu TQ, Okiji T. MicroRNA-27a-5p downregulates expression of proinflammatory cytokines in lipopolysaccharide-stimulated human dental pulp cells via the NF-κB signaling pathway Int. J. Mol. Sci.. 2024.09; 25 9694.

  6. Kawashima N, Okiji T. Characteristics of inflammatory mediators in dental pulp inflammation and the potential for their control Front. Dent. Med . 2024.08; 5 1426887. ( DOI )

  7. Tazawa, K., & Sasaki, H. Three-dimensional cellular visualization in mouse apical periodontitis using combined whole-mount staining and optical tissue clearing Journal of oral biosciences. 2023.03; 65 (1): 132-135. ( DOI )

  8. Tazawa, K., Jadhav, R., Azuma, M. M., Fenno, J. C., McDonald, N. J., & Sasaki, H. Hypochlorous acid inactivates oral pathogens and a SARS-CoV-2-surrogate. BMC oral health BMC oral health. 2023.02; 23 (1): 111. ( DOI )

  9. Tazawa, K., Azuma Presse, M. M., Furusho, H., Stashenko, P., & Sasaki. Revisiting the role of IL-1 signaling in the development of apical periodontitis Frontiers in Dental Medicine. 2022.08; 3 985558. ( DOI )

  10. Thoai Quoc Kieu, Kento Tazawa, Nobuyuki Kawashima, Sonoko Noda, Mayuko Fujii, Keisuke Nara, Kentaro Hashimoto, Peifeng Han, Takashi Okiji. Kinetics of LYVE-1-positive M2-like macrophages in developing and repairing dental pulp in vivo and their pro-angiogenic activity in vitro. Scientific Reports. 2022.05; 12 (1): 5176. ( PubMed, DOI )

  11. Orikasa S, Kawashima N, Tazawa K, Hashimoto K, Sunada-Nara K, Noda S, Fujii M, Akiyama T, Okiji T. Hypoxia-inducible factor 1α induces osteo/odontoblast differentiation of human dental pulp stem cells via Wnt/β-catenin transcriptional cofactor BCL9 Scientific Reports. 2022.01; 12 (682):

  12. Tazawa K, Azuma MM, Furusho H, Stashenko P, Sasaki H. Revisiting the role of IL-1 signaling in the development of apical periodontitis Frontiers in Dental Medicine. 2022;

  13. Kuramoto M, Kawashima N, Tazawa K, Nara K, Fujii M, Noda S, Hashimoto K, Nozaki K, Okiji T. Mineral trioxide aggregate suppresses pro-inflammatory cytokine expression via the calcineurin/nuclear factor of activated T cells/early growth response 2 pathway in lipopolysaccharide-stimulated macrophages. International endodontic journal. 2020.12; 53 (12): 1653-1665. ( PubMed, DOI )

  14. Tazawa K, Kawashima N, Kuramoto M, Noda S, Fujii M, Nara K, Hashimoto K, Okiji T. Transient receptor potential ankyrin 1 (TRPA1) is up-regulated in response to lipopolysaccharide via P38/ mitogen-activated protein kinase (MAPK) in dental pulp cells and promotes mineralization. American Journal of Pathology. 2020.12; 190 (12): 2417-2426.

  15. Fujii M, Kawashima N, Tazawa K, Hashimoto K, Nara K, Noda S, Nagai S, Okiji T.. Hypoxia-inducible factor 1α promotes interleukin 1β and tumour necrosis factor α expression in lipopolysaccharide-stimulated human dental pulp cells. International Endodontic Journal. 2020.01; ( DOI )

  16. Nara K, Kawashima N, Noda S, Fujii M, Hashimoto K, Tazawa K, Okiji T. Anti-inflammatory roles of microRNA 21 in lipopolysaccharide-stimulated human dental pulp cells. Journal of Cellular Physiology.. 2019.11; 234 (11): 21331-21341. ( PubMed, DOI )

  17. Fujii M, Kawashima N, Tazawa K, Hashimoto K, Nara K, Noda S, Kuramoto M, Orikasa S, Nagai S, Okiji T . HIF1α inhibits LPS-mediated induction of IL-6 synthesis via SOCS3-dependent CEBPβ suppression in human dental pulp cells Biochemical and Biophysical Research Communications . 2019.11; ( DOI )

  18. Bakhit A, Kawashima N, Hashimoto K, , Noda S, Nara K, , Kuramoto M, Tazawa K, Okiji T. Strontium ranelate promotes odonto-/osteogenic differentiation/mineralization of dental papillae cells in vitro and mineralized tissue formation of the dental pulp in vivo. Scientific Reports. 2018.06; ( PubMed, DOI )

  19. Tazawa K, Ikeda H, Kawashima N, Okiji T. Transient receptor potential melastatin (TRPM) 8 is expressed in freshly isolated native human odontoblasts. Archives of Oral Biology. 2017.03; 75 55-61. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. Alghamdi F, Tazawa K, Chunmei R, Oshima R, Ishidori M, Kawashima N, Okiji T. Metformin suppresses the expansion of periapical lesions and RANKL-dependent osteoclastogenesis. 第25回日本歯科医学会学術大会 2025.09 横浜

  2. Ren C, Tazawa K, Kawashima N, Okiji T, Yahata Y. Metformin Reduces Inflammation and Bone Loss in Apical Periodontitis. Interface Summer Seminar 2025 2025.08.01 仙台

  3. Ren C, Tazawa K, Kawashima N, Oshima R, Okada Y, Wang S, Yu Z, Ohsugi Y, Katagiri S, Okiji T. Metformin reduces inflammation and bone loss in apical periodontitis. International Association for Dental Research 2025.06 Barcelona

  4. Ren C, Tazawa K, Kawashima N, Okiji T . Metformin down-regulates alveolar bone destruction in experimentally-induced mice periapical lesions. TMDU-SPRING Retreat 2024 研究成果報告会 2024.09.11 浜松

  5. Ren C, Tazawa K, Kawashima N, Okiji T. Metformin down-regulates alveolar bone destruction in experimentally-induced mice periapical lesions. 第45回日本歯内療法学会学術大会 2024.07.20 大阪

  6. Chunmei R, Tazawa K, Kawashima N, Okiji T. Metformin suppresses pro-inflammatory cytokine expression in LPS-stimulated human dental pulp stem cells . 第44回日本歯内療法学会学術大会 2023.07.09 東京

  7. Thoai KQ, Tazawa K, Kawashima N, Noda S, Fujii M, Sunada-Nara K, Hashimoto K, Han P & Okiji T. LYVE-1+ M2-macrophages: identification in dental-pulp and their pro-angiogenic activity in-vitro. IADR/APR General Session & Exhibition 2022.06.20 VIRTUAL EXPERIENCE

  8. Han P, Sunada-Nara K, Kawashima N, Wang S, Thoai KQ, Yu Z, Okiji T . MicroRNA-146b suppresses proinflammatory mediators synthesis in lipopolysaccharide-stimulated dental pulp cells. 2022 IADR/APR General Session & Exhibition 2022.06.20 VIRTUAL EXPERIENCE

  9. Tazawa K, Chen D, King, P, Sasaki H. Challenge to identify lymphatic vessels in mouse dental pulp. School of Dentistry Research Day 2022 2022.02.17 Ann arbor, USA

  10. Tazawa K, Chen D, Azuma M, King P, Sasaki H. Functioning lymphatic vessels exist in mouse dental pulp. 2021 IADR /AADR /CADR General Session 2021.07.22 Virtual Meeting

  11. 折笠紫音. 低酸素誘導因子1αはWnt/β-catenin転写補助因子BCL9を介してヒト歯髄幹細胞の骨芽・象牙芽細胞分化を誘導する. 令和2年度バランスユニット若手研究者ワークショップ 2021.03.09 Web開催

  12. Kieu Quoc T, Tazawa K, Kawashima N, Nara K, Fujii M, Noda S, Hashimoto K, Okiji T. Lyve-1+ Pulpal Macrophages: M2-polarization and Response to Cavity Preparation. The 68th Annual Meeting of Japanese Assosiation for Dental Research 2020.11.07 Vertual Meeting

  13. 田澤建人, 川島伸之, 倉本将司, 奈良圭介, 藤井真由子, 野田園子, 橋本健太郎, 興地隆史. TRPA1チャネルはLPS刺激に応答しP38/MAPKを介して発現上昇し,歯髄細胞の石灰化を促進する. 令和元年度バランスユニット若手研究者ワークショップ 2020.02.07 東京

  14. Orikasa S, Kawashima N, Fujii M, Yamamoto M, Hashimoto K, Tazawa K, Okiji T. Hypoxic condition induces hypoxia-inducible factor 1α and upregulates Wnt/β-catenin transcriptional cofactors, Bcl9 and Bcl9l, in mouse dental papillae cells. The 21st KACD-JSCD Joint Scientific Meeting 2019.11.09 Seoul, Korea

  15. Mayuko F, Nobuyuki K, Shion O, Sonoko N, Keisuke N, Kentaro H, Kento T, Shigenori N, Takashi O. HIF1a inhibits LPS-mediated induction of IL-6 synthesis via SOCS3-dependent CEBPb suppression in human dental pulp cells. The 21th KACD-JSCD Joint Scientific Meeting 2019.11.09 Soul, South korea

  16. 倉本将司,川島伸之,田澤建人,奈良圭介,藤井真由子,野田園子,橋本健太郎,興地隆史. MTAはマクロファージからの炎症性メディエーター産生をcalcineurin/NFATシグナルを介して抑制する. 日本歯科保存学会2019年度秋季学術大会(第151回) 2019.11.08 博多

  17. Noda S, Kawashima N, Hashimoto K, Nara K, Kuramoto M, Tazawa K, Okiji T. In Vivo Mineralization and In Vitro Differentiation of Dense-Cultured DPSCs. 96th General Session & Exhibition of the IADR 2018.07.25 London, England

  18. Ikeda H, Aierken S, Tazawa K, Suda H, Okiji T. Quantitative analysis of changes in human enamel permeability after acid-etching/ whitening procedures. International Association for Dental Ressearch. Pulp Biology and Regeneration (PBRG) Symposium 2016.06.26 Nagoya

  19. Tazawa K, Ikeda H, Kawashima N, Ozawa M, Suda H, Okiji T. Expression of TRPM8 in freshly isolated human odontoblasts. 94th General Session and Exhibition of the IADR 2016.06.22 Seoul, Korea

  20. A.SAILIMAN, H. IKEDA, K. TAZAWA, J. GU, and H. SUDA. Permeability of Capsaicin through Human Enamel.. The 62nd Annual Meeting of Japanese Association for Dental Research 2014.12.05

  21. Tazawa K, Ikeda H, Suda H. Dynamic Changes in Lymphatic Network by Inflammation of Rat Pulp. The 62nd Annual Meeting of Japanese Association for Dental Research 2014.12.04

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Awards & Honors 【 display / non-display

  • The 2019th Japan Endodontic Association Best paper award,Japan Endodontic Association,2020.06

  • The 2019th Best performance award of Balance unit workshop for young researchers,2020.02

  • The 2018th Outstanding performance award of Balance unit workshop for young researchers,2019.01

Others 【 display / non-display

  • TRP channel meeting (Tazawa K, Ikeda H),2016.06

 

Social Contribution 【 display / non-display

  • Michigan Friday Japanese scholars forum,Michigan state USA,2021.09.01 - 2022.09.30