Personnel Information

写真a

TORII Satoru


Job title

Associate Professor

Laboratory Phone number

+81-3-5803-4797

Laboratory Fax number

+81-3-5803-4821

Mail Address

The inquiry by e-mail is 《here》

Research Areas, Keywords

autophagy, apoptosis, signal transduction, Parkinson's disease

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Graduating School 【 display / non-display 】

  • Kyoto University, Faculty of Science, 2001.03, Graduated

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Graduate School 【 display / non-display 】

  • Kyoto University, Master's Course, 2003.03, Completed

  • Kyoto University, Doctor's Course, 2006.03, Completed

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Campus Career 【 display / non-display 】

  • 2014.04
    -
    2016.12
    Tokyo Medical and Dental University， Medical Research Institute， Pathophysiology， Pathological Cell Biology， Project Junior Associate Professor
  • 2017.01
    -
    2017.03
    Tokyo Medical and Dental University， Medical Research Institute， Pathophysiology， Pathological Cell Biology， Junior Associate Professor
  • 2017.04
    -
    2020.12
    Tokyo Medical and Dental University， Medical Research Institute， Pathophysiology， Pathological Cell Biology， Junior Associate Professor
  • 2021.01
    -
    2022.04
    Tokyo Medical and Dental University， Medical Research Institute， Pathophysiology， Pathological Cell Biology， Associate Professor
  • 2022.05
    -
    2024.03
    Tokyo Medical and Dental University， Medical Research Institute， Division of Advanced Pathophysiological Science， Department of Pathological Cell Biology， Associate Professor
  • 2024.04
    -
    Now
    Tokyo Medical and Dental University， TMDU Advanced Research Institute (TMDU-ARIS)， Project Research Division， Pathological Cell Biology Laboratory， Associate Professor

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External Career 【 display / non-display 】

  • 2006.07
    -
    2014.03
    , Assistant Professor
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Research Areas 【 display / non-display 】

  • Cell biology

  • Neuroscience-general

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Published Papers & Misc 【 display / non-display 】

  1. Hasegawa T, Nakashima M, Torii S, Honda S and Shimizu S. Photo-protective role of alternative autophagy in human keratinocytes Autophagy Reports. 2024.08;

  2. Hasegawa T, Noguchi S, Nakashima M, Miyai M, Goto M, Matsumoto Y, Torii S, Honda S, Shimizu S. Alternative autophagy dampens UVB-induced NLRP3 inflammasome activation in human keratinocytes. The Journal of biological chemistry. 2024.03; 300 (4): 107173. ( PubMed, DOI )

  3. Chang S, Torii S, Inamo J, Ishikawa K, Kochi Y, Shimizu S. Uncovering the Localization and Function of a Novel Read-Through Transcript 'TOMM40-APOE'. Cells. 2023.12; 13 (1): ( PubMed, DOI )

  4. Sakurai HT, Arakawa S, Yamaguchi H, Torii S, Honda S, Shimizu S. An Overview of Golgi Membrane-Associated Degradation (GOMED) and Its Detection Methods. Cells. 2023.12; 12 (24): ( PubMed, DOI )

  5. Torii S, Arakawa S, Sato S, Ishikawa KI, Taniguchi D, Sakurai HT, Honda S, Hiraoka Y, Ono M, Akamatsu W, Hattori N, Shimizu S. Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2. EMBO molecular medicine. 2023.08; 15 (9): e17451. ( PubMed, DOI )

  6. Yanagi T, Kikuchi H, Susa K, Takahashi N, Bamba H, Suzuki T, Nakano Y, Fujiki T, Mori Y, Ando F, Mandai S, Mori T, Takeuchi K, Honda S, Torii S, Shimizu S, Rai T, Uchida S, Sohara E. Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression. Genes to cells. 2022.11; 28 (1): 5-14. ( PubMed, DOI )

  7. Kasai S, Li X, Torii S, Yasumoto KI, Sogawa K. Direct protein-protein interaction between Npas4 and IPAS mutually inhibits their critical roles in neuronal cell survival and death. Cell death discovery. 2021.10; 7 (1): 300. ( PubMed, DOI )

  8. Daniel J Klionsky, etc.. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021.02; 1-382. ( PubMed, DOI )

  9. Sato S, Noda S, Torii S, Amo T, Ikeda A, Funayama M, Yamaguchi J, Fukuda T, Kondo H, Tada N, Arakawa S, Watanabe M, Uchiyama Y, Shimizu S, Hattori N. Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice. Human molecular genetics. 2021.02; 30 (6): 443-453. ( PubMed, DOI )

  10. Satoru Torii, Shinya Honda, Michiko Murohashi, Hirofumi Yamaguchi, Shigeomi Shimizu. Autophagy involvement in oncogenesis. Cancer Science. 2020.11; 111 (11): 3993-3999. ( PubMed, DOI )

  11. Torii Satoru, Honda Shinya, Murohashi Michiko, Yamaguchi Hirofumi, Shimizu Shigeomi. 癌発生におけるオートファジーの関与(Autophagy involvement in oncogenesis) Cancer Science. 2020.11; 111 (11): 3993-3999. ( ichushi )

  12. Hirofumi Yamaguchi, Shinya Honda, Satoru Torii, Kimiko Shimizu, Kaoru Katoh, Koichi Miyake, Noriko Miyake, Nobuhiro Fujikake, Hajime Tajima Sakurai, Satoko Arakawa, Shigeomi Shimizu. Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration. Nature Communications. 2020.10; 11 (1): 5311. ( PubMed, DOI )

  13. Satoru Torii, Shigeomi Shimizu. Involvement of phosphorylation of ULK1 in alternative autophagy Autophagy. 2020.06; 16 (8): 1532-1533. ( PubMed, DOI )

  14. Satoru Torii, Hirofumi Yamaguchi, Akira Nakanishi, Satoko Arakawa, Shinya Honda, Kenta Moriwaki, Hiroyasu Nakano, Shigeomi Shimizu. Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy Nature Communications. 2020.04; 11 (1): 1754. ( PubMed, DOI )

  15. Hironori Kato, Kohki Okabe, Masato Miyake, Kazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, Masaya Ono, Yusuke Saito, Takashi Sugiyama, Takashi Funatsu, Katsuaki Sato, Shigeomi Shimizu, Seiichi Oyadomari, Hidenori Ichijo, Hisae Kadowaki, Hideki Nishitoh. ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue. Life Science Alliance. 2020.03; 3 (3): ( PubMed, DOI )

  16. Satoru Torii, Shuya Kasai, Tatsushi Yoshida, Ken-Ichi Yasumoto, Shigeomi Shimizu. Mitochondrial E3 Ubiquitin Ligase Parkin: Relationships with Other Causal Proteins in Familial Parkinson's Disease and Its Substrate-Involved Mouse Experimental Models. International Journal of Molecular Sciences. 2020.02; 21 (4): ( PubMed, DOI )

  17. Kana Otsubo, Chiaki Maeyashiki, Yoichi Nibe, Akiko Tamura, Emi Aonuma, Hiroki Matsuda, Masanori Kobayashi, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Satoru Torii, Eisuke Itakura, Mamoru Watanabe, Shigeru Oshima. Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells. FEBS Letters. 2020.01; 594 (10): 1586-1595. ( PubMed, DOI )

  18. Shinya Honda, Satoko Arakawa, Hirofumi Yamaguchi, Satoru Torii, Hajime Tajima Sakurai, Masatsune Tsujioka, Michiko Murohashi, Shigeomi Shimizu. Association Between Atg5-independent Alternative Autophagy and Neurodegenerative Diseases. Journal of Molecular Biology. 2020.01; 432 (8): 2622-2632. ( PubMed, DOI )

  19. Naoto Muraoka, Kaori Nara, Fumiya Tamura, Hidenori Kojima, Hiroyuki Yamakawa, Taketaro Sadahiro, Kazutaka Miyamoto, Mari Isomi, Sho Haginiwa, Hidenori Tani, Shota Kurotsu, Rina Osakabe, Satoru Torii, Shigeomi Shimizu, Hideyuki Okano, Yukihiko Sugimoto, Keiichi Fukuda, Masaki Ieda. Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming. Nature Communications. 2019.02; 10 (1): 674. ( PubMed, DOI )

  20. Meruna Nagata, Satoko Arakawa, Hirofumi Yamaguchi, Satoru Torii, Hazuki Endo, Masatsune Tsujioka, Shinya Honda, Yuya Nishida, Akimitsu Konishi, Shigeomi Shimizu. Dram1 regulates DNA damage-induced alternative autophagy. Cell Stress. 2018.03; 2 (3): 55-65. ( PubMed, DOI )

  21. Shuya Kasai, Mary Jane Elizabeth Richardson, Satoru Torii, Ken-Ichi Yasumoto, Hiroki Shima, Kazuhiko Igarashi, Ken Itoh, Kazuhiro Sogawa, Kazutaka Murayama. Increase in pro-apoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2. FEBS Journal. 2017.10; 284 (23): 4115-4127. ( PubMed, DOI )

  22. Hidefumi Iwashita , Satoru Torii, Noriyoshi Nagahora, Munetaka Ishiyama, Kosei Shioji, Kazumi Sasamoto, Shigeomi Shimizu, and Kentaro Okuma. Live Cell Imaging of Mitochondrial Autophagy with a Novel Fluorescent Small Molecule ACS Chem. Biol.. 2017.09; 12 (10): 2546-2551. ( DOI )

  23. Satoko Arakawa, Shinya Honda, Satoru Torii, Masatsune Tsujioka, Shigeomi Shimizu. Monitoring of Atg5-Independent Mitophagy. Methods in Molecular Biology. 2017.04; 1759 125-132. ( PubMed, DOI )

  24. Yuichiro Watanabe, Shinya Honda, Akimitsu Konishi, Satoko Arakawa, Michiko Murohashi, Hirofumi Yamaguchi, Satoru Torii, Minoru Tanabe, Shinji Tanaka, Eiji Warabi, Shigeomi Shimizu. Autophagy controls centrosome number by degrading Cep63. Nature Communications. 2016.11; 7 13508. ( PubMed, DOI )

  25. Satoru Torii, Tatsushi Yoshida, Satoko Arakawa, Shinya Honda, Akira Nakanishi, Shigeomi Shimizu. Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress-induced autophagy. EMBO Reports. 2016.11; 17 (11): 1552-1564. ( PubMed, DOI )

  26. S Kasai, S Torii, A Kakita, K Sogawa. Inhibitory PAS domain protein is a substrate of PINK1 and Parkin and mediates cell death in a Parkinson's disease model. Cell Death Disease. 2015.09; 6 e1886. ( PubMed, DOI )

  27. S Torii, S Kasai, A Suzuki, Y Todoroki, K Yokozawa, K-I Yasumoto, N Seike, H Kiyonari, Y Mukumoto, A Kakita, K Sogawa. Involvement of inhibitory PAS domain protein in neuronal cell death in Parkinson's disease. Cell Death Discovery. 2015.08; 1 15015. ( PubMed, DOI )

  28. Satoru Torii, Kohei Sakaki, Miki Otomo, Kyohei Saka, Ken-ichi Yasumoto, Kazuhiro Sogawa. Nucleocytoplasmic shuttling of IPAS by its unique nuclear import and export signals unshared with other HIF-3α splice variants. Journal of Biochemistry. 2013.12; 154 (6): 561-567. ( PubMed, DOI )

  29. Yusuke Hiwatashi, Kohei Kanno, Chikahisa Takasaki, Kenji Goryo, Takuya Sato, Satoru Torii, Kazuhiro Sogawa, Ken-ichi Yasumoto. PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation. Experimental Cell Research. 2011.12; 317 (20): 2789-2799. ( PubMed, DOI )

  30. S Torii, Y Goto, T Ishizawa, H Hoshi, K Goryo, K Yasumoto, H Fukumura, K Sogawa. Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. Cell Death and Differentiation. 2011.11; 18 (11): 1711-1725. ( PubMed, DOI )

  31. Kenji Goryo, Satoru Torii, Ken-Ichi Yasumoto, Kazuhiro Sogawa. Tumour necrosis factor-α suppresses the hypoxic response by NF-κB-dependent induction of inhibitory PAS domain protein in PC12 cells. Journal of Biochemistry. 2011.09; 150 (3): 311-318. ( PubMed, DOI )

  32. Satoru Torii, Atsushi Kurihara, Xian Yu Li, Ken-ichi Yasumoto, Kazuhiro Sogawa. Inhibitory effect of extracellular histidine on cobalt-induced HIF-1alpha expression. Journal of Biochemistry. 2011.02; 149 (2): 171-176. ( PubMed, DOI )

  33. Yosuke Tomokuni, Kenji Goryo, Ayako Katsura, Satoru Torii, Ken-ichi Yasumoto, Klaus Kemnitz, Mamiko Takada, Hiroshi Fukumura, Kazuhiro Sogawa. Loose interaction between glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase revealed by fluorescence resonance energy transfer-fluorescence lifetime imaging microscopy in living cells. FEBS Journal. 2010.03; 277 (5): 1310-1318. ( PubMed, DOI )

  34. Takayuki Satoh, Satoru Torii, Kei Nakayama, Eisuke Nishida. CrkL is a novel target of Sprouty2 in fibroblast growth factor signaling. Genes to Cells. 2010.03; 15 (3): 161-168. ( PubMed, DOI )

  35. Satoru Torii, Norikazu Okamura, Yohei Suzuki, Toshiyuki Ishizawa, Ken-Ichi Yasumoto, Kazuhiro Sogawa. Cyclic AMP represses the hypoxic induction of hypoxia-inducible factors in PC12 cells. Journal of Biochemistry. 2009.12; 146 (6): 839-844. ( PubMed, DOI )

  36. Ayako Katsura, Kota Kimura, Kentaro Hosoi, Yosuke Tomokuni, Masanori Nesori, Kenji Goryo, Keiko Numayama-Tsuruta, Satoru Torii, Ken-Ichi Yasumoto, Osamu Gotoh, Mamiko Takada, Hiroshi Fukumura, Kazuhiro Sogawa. Transactivation activity of LBP-1 proteins and their dimerization in living cells. Genes to Cells. 2009.10; 14 (10): 1183-1196. ( PubMed, DOI )

  37. Satoru Torii, Kentaro Kobayashi, Masayuki Takahashi, Kasumi Katahira, Kenji Goryo, Natsuki Matsushita, Ken-Ichi Yasumoto, Yoshiaki Fujii-Kuriyama, Kazuhiro Sogawa. Magnesium deficiency causes loss of response to intermittent hypoxia in paraganglion cells. Journal of Biological Chemistry. 2009.07; 284 (28): 19077-19089. ( PubMed, DOI )

  38. Ken-ichi Yasumoto, Yusuke Kowata, Atsushi Yoshida, Satoru Torii, Kazuhiro Sogawa. Role of the intracellular localization of HIF-prolyl hydroxylases. Biochimica et Biophysica Acta -Molecular Cell Research. 2009.05; 1793 (5): 792-797. ( PubMed, DOI )

  39. Satoru Torii, Takuya Yamamoto, Yoshiki Tsuchiya, Eisuke Nishida. ERK MAP kinase in G cell cycle progression and cancer. Cancer Science. 2006.08; 97 (8): 697-702. ( PubMed, DOI )

  40. Kunio Kondoh, Satoru Torii, Eisuke Nishida. Control of MAP kinase signaling to the nucleus. Chromosoma. 2005.07; 114 (2): 86-91. ( PubMed, DOI )

  41. Satoru Torii, Kei Nakayama, Takuya Yamamoto, Eisuke Nishida. Regulatory mechanisms and function of ERK MAP kinases. Journal of Biochemistry. 2004.11; 136 (5): 557-561. ( PubMed, DOI )

  42. Satoru Torii, Morioh Kusakabe, Takuya Yamamoto, Momoko Maekawa, Eisuke Nishida. Sef is a spatial regulator for Ras/MAP kinase signaling. Developmental Cell. 2004.07; 7 (1): 33-44. ( PubMed, DOI )

  43. Hiroshi Hanafusa, Satoru Torii, Takayuki Yasunaga, Kunihiro Matsumoto, Eisuke Nishida. Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty. Journal of Biological Chemistry. 2004.05; 279 (22): 22992-22995. ( PubMed, DOI )

  44. Hiroshi Hanafusa, Satoru Torii, Takayuki Yasunaga, Eisuke Nishida. Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Nature Cell Biology. 2002.11; 4 (11): 850-858. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. 鳥居暁. 家族性パーキンソン病(PARK22)変異による発症メカニズムの解明と治癒化合物の開発研究. 2023年度難治疾患研究所研究発表会 2024.03.12 東京都文京区湯島

  2. Satoru Torii. Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson’s disease caused by CHCHD2. 東京医科歯科大学 YouTube 英語研究広報動画 2024.01.25 東京都文京区湯島

  3. 鳥居暁, 荒川聡子, 佐藤栄人, 石川景一, 谷口大祐, 桜井一, 本田真也, 平岡優一, 尾野雅哉, 赤松和土, 服部信孝, 清水重臣. Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson’s disease caused by CHCHD2 gene mutations. 第46回日本分子生物学会年会 2023.12.08

  4. Satoru Torii. Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson’s disease caused by CHCHD2.. The 18th international Symposium of the institute Network for Biomedical Science 2023.10.06 東京都文京区湯島

  5. 鈴木 行人, 高久 智生, 渡邊 直紀, 越智 清純, 鳥居 暁, 山田 和宏, 河村 踊子, 清水 重臣, 小松 則夫, 安藤 美樹. MAPK活性化とDrp1リン酸化により誘導されるCML細胞のAI検出可能なミトコンドリアの変化. 日本血液学会学術集会 2023.10.01

  6. 鈴木 行人, 高久 智生, 渡邊 直紀, 越智 清純, 鳥居 暁, 山田 和宏, 河村 踊子, 清水 重臣, 小松 則夫, 安藤 美樹. AIにより駆動するゴーストサイトメトリーはミトコンドリアの変化を捉えて非標識白血病細胞を判別する(AI-Driven Ghost Cytometry Enables Label-Free Identification of Leukemia Cells Through Mitochondrial Alterations). 日本癌学会総会記事 2023.09.01

  7. 鈴木 行人, 高久 智生, 渡邊 直紀, 越智 清純, 鳥居 暁, 山田 和宏, 河村 踊子, 清水 重臣, 小松 則夫, 安藤 美樹. MAPK活性化とDrp1リン酸化により誘導されるCML細胞のAI検出可能なミトコンドリアの変化. 日本血液学会学術集会 2022.10.01

  8. 鳥居　暁、山口啓史、中西啓、荒川聡子、本田真也、森脇健太、 中野裕康、清水重臣. 新規オートファジーに必須なUlk1のリン酸化とネクロプトーシス実行因子RIPK3の関与. 第１回 細胞死コロキュアム 2020.11.11 Web開催

  9. Satoru Torii, Hirofumi Yamaguchi, Akira Nakanishi, Satoko Arakawa, Shinya Honda, Kenta Moriwaki, Hiroyasu Nakano, and Shigeomi Shimizu . Regulation of phosphorylation of Ulk1 in alternative autophagy. The 15th International Symposium of the Institute Network for Biomedical Sciences 2020.11.05

  10. Torii S, Shimizu S.. Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy. 東京医科歯科大学YouTube英語研究広報動画 2020.10.29 東京都文京区湯島

  11. Satoru Torii. Regulation of DNA damage-induced apoptosis by autophagy. 湯島若手塾 2019.03.18 東京都文京区湯島

  12. Satoru Torii, Tatsushi Yoshida, Satoko Arakawa, Shinya Honda, Shigeomi Shimizu. The role of PPM1D in regulating DNA damage-induced autophagy. Workshop on Frontiers in Phophatase Research and Drug 2018.10.23

  13. Satoru Torii, Tatsushi Yoshida, Satoko Arakawa, Shinya Honda, Shigeomi Shimizu. Regulation of DNA damage-induced apoptosis by autophagy. Australia-Japan Meeting on Cell Death 2018.05.22 Tokyo, Japan

  14. 鳥居 暁　吉田達士　荒川聡子　本田真也　清水重臣. Regulation of DNA damage-induced apoptosis by autophagy. ConBio2017 生命科学系学会合同年次大会 2017.12.06 神戸

  15. Satoru Torii, Tatsushi Yoshida, Satoko Arakawa, Shinya Honda, Shigeomi Shimizu. The role of PPM1D in regulating DNA damage-induced autophagy. The 8th International Symposium on Autophagy (ISA) 2017.05.29 Nara

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Others 【 display / non-display 】

  • New insights into the development of Parkinson's disease in the brain，2023.09

  • How Cells Decide the Way They Want to Recycle Their Content，2020.05

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Campus class subject 【 display / non-display 】

  • Molecular and Cellular Biology，2021 - Now

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