Personnel Information

写真a

MIZUNO Mitsuru


Job title

Assistant Professor
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Graduating School 【 display / non-display 】

  • Nihon University, 2010.03, Graduated

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Graduate School 【 display / non-display 】

  • Yokohama City University, Graduate School, Division of Medicine, Doctor's Course, 2014.03, Completed

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Campus Career 【 display / non-display 】

  • 2014.04
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    2016.03
    Tokyo Medical and Dental University， Research and Industry-University Alliance Organization， Center for Stem Cell and Regenerative Medicine， Project Researcher
  • 2014.04
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    2016.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Advanced Therapeutic Sciences， Applied Regenerative Medicine， Project Researcher
  • 2016.04
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    2017.03
    Tokyo Medical and Dental University， Research and Industry-University Alliance Organization， Center for Stem Cell and Regenerative Medicine， Assistant Professor
  • 2017.04
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    2018.10
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Center for Stem Cell and Regenerative Medicine， Assistant Professor
  • 2018.11
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    2020.09
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Center for Stem Cell and Regenerative Medicine， Assistant Professor
  • 2020.10
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    2022.02
    Tokyo Medical and Dental University， Institute of Research， Division of Advanced Research， Center for Stem Cell and Regenerative Medicine， Assistant Professor
  • 2022.03
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    2023.04
    Tokyo Medical and Dental University， Institute of Research， a， Center for Stem Cell and Regenerative Medicine， Assistant Professor
  • 2023.05
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    Now
    Tokyo Medical and Dental University， Institute of Research， a， Center for Stem Cell and Regenerative Medicine， Assistant Professor

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Qualification Acquired 【 display / non-display 】

  • Veterinarian

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Published Papers & Misc 【 display / non-display 】

  1. Mitsuru Mizuno, Yoshitaka Maeda, Sho Sanami, Takahisa Matsuzaki, Hiroshi Y Yoshikawa, Nobutake Ozeki, Hideyuki Koga, Ichiro Sekiya. Noninvasive total counting of cultured cells using a home-use scanner with a pattern sheet. iScience. 2024.03; 27 (3): 109170. ( PubMed, DOI )

  2. Mitsuru Mizuno, Koki Abe, Takashi Kakimoto, Hisashi Hasebe, Naoki Kagi, Ichiro Sekiya. Operator-derived particles and falling bacteria in biosafety cabinets. Regenarative Therapy. 2024.03; 25 264-272. ( PubMed, DOI )

  3. Mitsuru Mizuno, Koki Abe, Takashi Kakimoto, Keiichi Yano, Yukiko Ota, Kengo Tomita, Naoki Kagi, Ichiro Sekiya. Volatile organic compounds and ionic substances contamination in cell processing facilities during rest period; a preliminary assessment of exposure to cell processing operators. Regen Ther. 2023.12; 24 211-218. ( PubMed, DOI )

  4. Hisako Katano, Nobutake Ozeki, Mitsuru Mizuno, Kentaro Endo, Noriya Okanouchi 1,2, Jo Fujita, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya. Morphological analysis of three-dimensional MR images of patellofemoral joints in asymptomatic subjects Sci Rep. 2023.12;

  5. Mizuno M, Matsuda J, Watanabe K, Shimizu N, Sekiya I. Effect of disinfectants and manual wiping for processing the cell product changeover in a biosafety cabinet. Regenerative therapy. 2023.03; 22 169-175. ( PubMed, DOI )

  6. Ozeki N, Mizuno M, Yanada S, Okada T, Kubota R, Kushida Y, Furuoka H, Endo K, Katano H, Nakamura K, Ohya S, Koga H, Sekiya I. Autologous Synovial Mesenchymal Stem Cell Transplantation Suppresses Inflammation Caused by Synovial Harvesting and Promotes Healing in a Micro Minipig Repaired Meniscus Model. Transplantation proceedings. 2023.03; 55 (2): 470-480. ( PubMed, DOI )

  7. Mitsuru Mizuno, Kouichirou Yori, Toshikazu Takeuchi, Tetsuya Yamaguchi, Ken Watanabe, Yasuhiro Tomaru, Norio Shimizu, Ichiro Sekiya. Cross-contamination risk and decontamination during changeover after cell-product processing. Regenerative Therapy. 2022.12; 22 30-38. ( PubMed, DOI )

  8. Shunichi Fujii, Kentaro Endo, Nobutake Ozeki, Yuriko Sakamaki, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Comparison of adhesion of thawed and cultured synovial mesenchymal stem cells to the porcine meniscus and the relevance of cell surface microspike BMC Molecular and Cell Biology. 2022.12; 23 (1): 53. ( PubMed, DOI )

  9. Mitsuru Mizuno, Yoshimi Sugahara, Daisuke Iwayama, Noe Miyashita, Hisako Katano, Ichiro Sekiya. Stress and motivation of cell processing operators: A pilot study of an online questionnaire survey. Regenerative Therapy. 2022.11; 21 547-552. ( PubMed, DOI )

  10. Takahiro Tanimoto, Kentaro Endo, Yuriko Sakamaki, Nobutake Ozeki, Hisako Katanom, Mitsuru Mizuno, Hideyuki Koga, Ichiro Sekiya .. Human synovial mesenchymal stem cells show time-dependent morphological changes and increased adhesion to degenerated porcine cartilage. Scientific Reports. 2022.10; 12 (1): 16619. ( PubMed, DOI )

  11. Mituru Mizuno, Nobutake Ozeki, Ichiro Sekiya. Safety of using cultured cells with trisomy 7 in cell therapy for treating osteoarthritis. Regenerative Therapy. 2022.06; 17 (21): 81-86. ( PubMed, DOI )

  12. Mituru Mizuno,Takahisa Matsuzaki, Nobutake Ozeki, Hisako Katano, Hideyuki Koga, Takanori Takebe, Hiroshi Yoshikawa, Ichiro Sekiya. Cell membrane fluidity and ROS resistance define DMSO tolerance of cryopreserved synovial MSCs and HUVECs. Stem Cell Research & Therapy. 2022.05; 13 (1): 177. ( PubMed, DOI )

  13. Sekiya I, Koga H, Katano H, Mizuno M, Kohno Y, Otabe K, Ozeki N. . Second-look arthroscopy after meniscus repair and synovial mesenchymal stem cell transplantation to treat degenerative flaps and radial tears of the medial meniscus: J Orthop Sci. 2022.05; 27 (4): 821-834. ( PubMed, DOI )

  14. Yuji Kohno, Hideyuki Koga, Nobutake Ozeki, Junpei Matsuda, Mitsuru Mizuno, Hisako Katano, Ichiro Sekiya. Biomechanical analysis of a centralization procedure for extruded lateral meniscus after meniscectomy in porcine knee joints. Journal Orthopaedic Research. 2022.05; 40 (5): 1097-1103. ( PubMed, DOI )

  15. Yuji Kohno, Mitsuru Mizuno, Kentaro Endo, Nobutake Ozeki, Hisako Katano, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Hideyuki Koga, Ichiro Sekiya. Yields of mesenchymal stromal cells from synovial fluid reflect those from synovium in patients with rheumatoid arthritis Tissue and Cell. 2022.04; 75 101727. ( PubMed, DOI )

  16. Mitsuru Mizuno, Kentaro Endo, Hisako Katano, Naoki Amano, Masaki Nomura, Yoshinori Hasegawa, Nobutake Ozeki, Hideyuki Koga, Naoko Takasu, Osamu Ohara, Tomohiro Morio, Ichiro Sekiya. Transplantation of human autologous synovial mesenchymal stem cells with trisomy 7 into the knee joint and 5 years of follow-up. Stem Cells Transl Med. 2021.11; 10 (11): 1530-1543. ( PubMed, DOI )

  17. Misaki Yagi, Mitsuru Mizuno, Ryota Fujisawa, Hisako Katano, Kentaro Endo, Nobutake Ozeki, Yuriko Sakamaki, Hideyuki Koga, Ichiro Sekiya. Optimal Pore Size of Honeycomb Polylactic Acid Films for In Vitro Cartilage Formation by Synovial Mesenchymal Stem Cells. Stem Cells Int. 2021.08; 2021 9239728. ( PubMed, DOI )

  18. Ichiro Sekiya, Hisako Katano, Mitsuru Mizuno, Hideyuki Koga, Jun Masumoto, Makoto Tomita, Nobutake Ozeki. Alterations in cartilage quantification before and after injections of mesenchymal stem cells into osteoarthritic knees. Sci Rep. 2021.07; 11 (1): 13832. ( PubMed, DOI )

  19. Nobutake Ozeki, Yusuke Nakagawa, Mitsuru Mizuno, Yuji Kohno, Hisako Katano, Hideyuki Koga, Ichiro Sekiya. Ultrasound-Guided Harvesting of Synovium for Regenerative Medicine of Cartilage and Meniscus Using Synovial Mesenchymal Stem Cells. Arthrosc Tech. 2021.07; 10 (7): e1723-e1727. ( PubMed, DOI )

  20. Kiyotaka Horiuchi, Nobutake Ozeki, Kentaro Endo, Mitsuru Mizuno, Hisako Katano, Masako Akiyama, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Thawed cryopreserved synovial mesenchymal stem cells show comparable effects to cultured cells in the inhibition of osteoarthritis progression in rats. Sci Rep. 2021.05; 11 (1): 9683. ( PubMed, DOI )

  21. Ozeki Nobutake, Kohno Yuji, Kushida Yoshihisa, Watanabe Naoto, Mizuno Mitsuru, Katano Hisako, Masumoto Jun, Koga Hideyuki, Sekiya Ichiro. Synovial mesenchymal stem cells promote the meniscus repair in a novel pig meniscus injury model JOURNAL OF ORTHOPAEDIC RESEARCH. 2021.01; 39 (1): 177-183. ( PubMed, DOI )

  22. Horiuchi Kiyotaka, Mizuno Mitsuru, Katano Hisako, Endo Kentaro, Ozeki Nobutake, Tsuji Kunikazu, Koga Hideyuki, Sekiya Ichiro.. Optimal initial cell density that yields the highest number of primary synovial mesenchymal stem cells in a clinical setting. J Med Dent Sci.. 2021.01; 68 17-26. ( DOI )

  23. Yoshihisa Kushida, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Kunikazu Tsuji, Hideyuki Koga, Koichiro Kishima, Yoshio Soma, Ichiro Sekiya. Two- and three-dimensional optical coherence tomography to differentiate degenerative changes in a rat meniscectomy model. J Orthop Res. 2020.12; 38 (12): 2592-2600. ( PubMed, DOI )

  24. Watanabe Naoto, Endo Kentaro, Komori Keiichiro, Ozeki Nobutake, Mizuno Mitsuru, Katano Hisako, Kohno Yuji, Tsuji Kunikazu, Koga Hideyuki, Sekiya Ichiro. Mesenchymal Stem Cells in Synovial Fluid Increase in Knees with Degenerative Meniscus Injury after Arthroscopic Procedures through the Endogenous Effects of CGRP and HGF. STEM CELL REVIEWS AND REPORTS. 2020.12; 16 (6): 1305-1315. ( PubMed, DOI )

  25. Mizuno M, Endo K, Katano H, Tsuji A, Kojima N, Watanabe K, Shimizu N, Morio T, Sekiya I. The environmental risk assessment of cell-processing facilities for cell therapy in a Japanese academic institution. PloS one. 2020.08; 15 (8): e0236600. ( PubMed, DOI )

  26. So Suzuki, Mitsuru Mizuno, Yuriko Sakamaki, Ayako Mimata, Kentaro Endo, Yuji Kohno, Nobutake Ozeki, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Morphological changes in synovial mesenchymal stem cells during their adhesion to the meniscus. Lab. Invest.. 2020.07; 100 (7): 916-927. ( PubMed, DOI )

  27. Rei Kubota, Hideyuki Koga, Nobutake Ozeki, Junpei Matsuda, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Ichiro Sekiya. The effect of a centralization procedure for extruded lateral meniscus on load distribution in porcine knee joints at different flexion angles. BMC Musculoskelet Disord. 2020.04; 21 (1): 205. ( PubMed, DOI )

  28. Nobutake Ozeki, Hideyuki Koga, Junpei Matsuda, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Tomoyuki Saito, Takeshi Muneta, Ichiro Sekiya. Biomechanical analysis of the centralization procedure for extruded lateral menisci with posterior root deficiency in a porcine model. J Orthop Sci.. 2020.01; 25 (1): 161-166. ( PubMed, DOI )

  29. Mitsuru Mizuno, Hisako Katano, Yuri Shimozaki, Sho Sanami, Nobutake Ozeki, Hideyuki Koga, Ichiro Sekiya. Time-lapse image analysis for whole colony growth curves and daily distribution of the cell number per colony during the expansion of mesenchymal stem cells. Sci Rep. 2019.11; 9 (1): 16835. ( PubMed, DOI )

  30. Naoto Watanabe, Mitsuru Mizuno, Junpei Matsuda, Naoko Nakamura, Koji Otabe, Hisako Katano, Nobutake Ozeki, Yuji Kohno, Tsuyoshi Kimura, Kunikazu Tsuji, Hideyuki Koga, Akio Kishida, Ichiro Sekiya. Comparison of High-Hydrostatic-Pressure Decellularized Versus Freeze-Thawed Porcine Menisci. J. Orthop. Res.. 2019.11; 37 (11): 2466-2475. ( PubMed, DOI )

  31. Ichiro Sekiya, Hideyuki Koga, Koji Otabe, Yusuke Nakagawa, Hisako Katano, Nobutake Ozeki, Mitsuru Mizuno, Masafumi Horie, Yuji Kohno, Kenta Katagiri, Naoto Watanabe, Takeshi Muneta. Additional Use of Synovial Mesenchymal Stem Cell Transplantation Following Surgical Repair of a Complex Degenerative Tear of the Medial Meniscus of the Knee: A Case Report. Cell Transplant. 2019.11; 28 (11): 1445-1454. ( PubMed, DOI )

  32. Akinobu Hyodo, Nobutake Ozeki, Yuji Kohno, So Suzuki, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Makoto Tomita, Yusuke Nakagawa, Hideyuki Koga, Shinji Kiuchi, Kenji Suzuki, Yoshinori Itai, Jun Masumoto, Ichiro Sekiya. Projected Cartilage Area Ratio Determined by 3-Dimensional MRI Analysis: Validation of a Novel Technique to Evaluate Articular Cartilage. JB JS Open Access. 2019.10; 4 (4): e0010. ( PubMed, DOI )

  33. Shimpei Kondo, Yusuke Nakagawa, Mitsuru Mizuno, Kenta Katagiri, Kunikazu Tsuji, Shinji Kiuchi, Hideo Ono, Takeshi Muneta, Hideyuki Koga, Ichiro Sekiya. Transplantation of Aggregates of Autologous Synovial Mesenchymal Stem Cells for Treatment of Cartilage Defects in the Femoral Condyle and the Femoral Groove in Microminipigs. Am J Sports Med. 2019.08; 47 (10): 2338-2347. ( PubMed, DOI )

  34. Ryota Fujisawa, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Cryopreservation in 95% serum with 5% DMSO maintains colony formation and chondrogenic abilities in human synovial mesenchymal stem cells. BMC Musculoskelet Disord. 2019.07; 20 (1): 316. ( PubMed, DOI )

  35. Kaori Nakamura, Kunikazu Tsuji, Mitsuru Mizuno, Hideyuki Koga, Takeshi Muneta, Ichiro Sekiya. Initial cell plating density affects properties of human primary synovial mesenchymal stem cells. J. Orthop. Res.. 2019.06; 37 (6): 1358-1367.

  36. Naritomi M, Mizuno M, Katano H, Ozeki N, Otabe K, Komori K, Fujii S, Ichinose S, Tsuji K, Koga H, Muneta T, Sekiya I. Petaloid recombinant peptide enhances in vitro cartilage formation by synovial mesenchymal stem cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2019.06; 37 (6): 1350-1357. ( PubMed, DOI )

  37. Nakamura Kaori, Tsuji Kunikazu, Mizuno Mitsuru, Koga Hideyuki, Muneta Takeshi, Sekiya Ichiro. Initial cell plating density affects properties of human primary synovial mesenchymal stem cells JOURNAL OF ORTHOPAEDIC RESEARCH. 2019.06; 37 (6): 1358-1367. ( DOI )

  38. Akari Sasaki, Mitsuru Mizuno, Manabu Mochizuki, Ichiro Sekiya. Mesenchymal stem cells for cartilage regeneration in dogs. World J Stem Cells. 2019.05; 11 (5): 254-269. ( PubMed, DOI )

  39. Akari Sasaki, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Koji Otabe, Kunikazu Tsuji, Hideyuki Koga, Manabu Mochizuki, Ichiro Sekiya. Canine mesenchymal stem cells from synovium have a higher chondrogenic potential than those from infrapatellar fat pad, adipose tissue, and bone marrow. PLoS ONE. 2018.08; 13 (8): e0202922. ( PubMed, DOI )

  40. Katano H, Koga H, Ozeki N, Otabe K, Mizuno M, Tomita M, Muneta T, Sekiya I.. Trends in isolated meniscus repair and meniscectomy in Japan, 2011-2016. PLoS ONE. 2018.07; 23 (4): 676-681. ( PubMed, DOI )

  41. Ogata Yusuke, Mabuchi Yo, Shinoda Kosuke, Horiike Yuta, Mizuno Mitsuru, Otabe Koji, Suto Eriko Grace, Suzuki Nobuharu, Sekiya Ichiro, Akazawa Chihiro. Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage Regenerative Therapy. 2018.06; 8 20-28. ( DOI )

  42. Ogata Yusuke, Mabuchi Yo, Shinoda Kosuke, Horiike Yuta, Mizuno Mitsuru, Otabe Koji, Suto Eriko Grace, Suzuki Nobuharu, Sekiya Ichiro, Akazawa Chihiro. Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage(和訳中) Regenerative Therapy. 2018.06; 8 20-28. ( ichushi )

  43. Mitsuru Mizuno, Hisako Katano, Yo Mabuchi, Yusuke Ogata, Shizuko Ichinose, Shizuka Fujii, Koji Otabe, Keiichiro Komori, Nobutake Ozeki, Hideyuki Koga, Kunikazu Tsuji, Chihiro Akazawa, Takeshi Muneta, Ichiro Sekiya. Specific markers and properties of synovial mesenchymal stem cells in the surface, stromal, and perivascular regions. Stem Cell Research & Therapy. 2018.05; 9 (1): 123. ( PubMed, DOI )

  44. Sekiya Ichiro, Koga Hideyuki, Otabe Koji, Nakagawa Yusuke, Katano Hisako, Ozeki Nobutake, Mizuno Mitsuru, Horie Masafumi, Muneta Takeshi. Regenerative medicine in Knee 変性半月板断裂に対する修復+滑膜幹細胞移植の2年成績(Regenerative medicine in Knee Transplantation of synovial stem cells onto degenerative torn meniscus: a 2-year follow-up study) JOSKAS. 2018.05; 43 (4): 171. ( ichushi )

  45. Ken Watanabe, Koji Otabe, Norio Shimizu, Keiichirou Komori, Mitsuru Mizuno, Hisako Katano, Hideyuki Koga, Ichiro Sekiya. High-sensitivity virus and mycoplasma screening test reveals high prevalence of parvovirus B19 infection in human synovial tissues and bone marrow. Stem Cell Res Ther. 2018.03; 9 (1): 80. ( PubMed, DOI )

  46. Yuji Kohno, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Koji Otabe, Hideyuki Koga, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Ichiro Sekiya. Comparison of mesenchymal stem cells obtained by suspended culture of synovium from patients with rheumatoid arthritis and osteoarthritis. BMC Musculoskelet Disord. 2018.03; 19 (1): 78. ( PubMed, DOI )

  47. Kondo S, Muneta T, Nakagawa Y, Koga H, Watanabe T, Tsuji K, Sotome S, Okawa A, Kiuchi S, Ono H, Mizuno M, Sekiya I.. Transplantation of Autologous Synovial Mesenchymal Stem Cells Promotes Meniscus Regeneration in Aged Primates Journal of Orthopaedic Research. 2017.06; 35 (6): 1274-1282. ( PubMed, DOI )

  48. Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yuji Kohno, Shizuka Fujii, Nobutake Ozeki, Masafumi Horie, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta, Ichiro Sekiya. Complete human serum maintains viability and chondrogenic potential of human synovial stem cells: suitable conditions for transplantation. Stem Cell Research & Therapy. 2017.06; 8 (1): 144. ( PubMed, DOI )

  49. Yuji Kohno, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Keiichiro Komori, Shizuka Fujii, Koji Otabe, Masafumi Horie, Hideyuki Koga, Kunikazu Tsuji, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Takeshi Muneta, Ichiro Sekiya. Yields and chondrogenic potential of primary synovial mesenchymal stem cells are comparable between rheumatoid arthritis and osteoarthritis patients. Stem Cell Res Ther. 2017.05; 8 (1): 115. ( PubMed, DOI )

  50. Mikio Shioda, Takeshi Muneta, Kunikazu Tsuji, Mitsuru Mizuno, Keiichiro Komori, Hideyuki Koga, Ichiro Sekiya. TNFα promotes proliferation of human synovial MSCs while maintaining chondrogenic potential. PLoS ONE. 2017.05; 12 (5): e0177771. ( PubMed, DOI )

  51. Katagiri Kenta, Yu Matsukura, Takeshi Muneta, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Ichiro Sekiya.. Fibrous synovium releases higher numbers of mesenchymal stem cells than adipose synovium in a suspended synovium culture model. Arthroscopy. 2017.04; 33 (4): 800-810. ( PubMed )

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Conference Activities & Talks 【 display / non-display 】

  1. Akinobu Hyodo. Nobutake Ozeki, Hayato Aoki, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kenji Suzuki, Jun Masumoto, Ichiro Sekiya.. Radial Projected Femoral Cartilage Area By Automatic Cartilage Segmentation For The Knee MRI.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.11 Phoenix,USA

  2. Yoshihisa Kushida, Nobutake Ozeki, Hisako Katano, Mitsuru Mizuno, Ichiro Sekiya.. 2D And 3D Optical Coherence Tomography To Differentiate Degenerative Changes In A Rat Meniscectomy Model.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.11 Phoenix,USA

  3. So Suzuki, Mitsuru Mizuno, Yuji Kohno, Nobutake Ozeki, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Quantitative Morphological Analysis Of Synovial Mesenchymal Stem Cells During Adhesion To The Meniscus.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.10 Phoenix,USA

  4. Naoto Watanabe, Mitsuru Mizuno, Junpei Matsuda, Naoko Nakamura, Tsuyoshi Kimura, Kunikazu Tsuji, Akio Kishida, Ichiro Sekiya.. The Amount Of Collagen Is Not Related To Mechanical Properties Of High Hydrostatic Pressure-decellularized Meniscus And Freeze-thawed Meniscus.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.09 Phoenix,USA

  5. Hayato Aoki, Nobutake Ozeki, Akinobu Hyodo, Yuji Kohno, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kenji Suzuki, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya.. Learning Times And Segmentation Accuracy Of U-net Convolutional Neural Networks On Automatic Segmentation For Mri Of Knee.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.09 Phoenix,USA

  6. Nobutake Ozeki, Hideyuki Koga, Hayato Aoki, Akinobu Hyodo, Hiroki Katagiri, Yusuke Nakagawa, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Kenji Suzuki, Jun Masumoto, Ichiro Sekiya.. 3D MRI Analysis For Cartilage In Anterior Cruciate Ligament Deficient Knee.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.08 Phoenix,USA

  7. Rei Kubota, Hideyuki Koga, Nobutake Ozeki, Yuji Kohno, Junpei Matsuda, Yoshihisa Kushida, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Ichiro Sekiya.. The Effect Of Centralization Procedure For Extruded Lateral Meniscus On Load Distributionin Porcine Knee Joints At 30-90 Degrees Of Flexion.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.08 Phoenix,USA

  8. Kiyotaka Horiuchi, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Comparison Between Cultured Mscs And Non-cultured Mscs After Cryopreservation For Intra-articular Injections Into The Knee In A Rat Oa Model.. Orthopaedic Research Society 2020 Annual Meeting 2020.02.08 Phoenix,USA

  9. Akinobu Hyodo,Nobutake Ozeki, Yuji Kohno, So Suzuki, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Makoto Tomita, Yusuke Nakagawa, Hideyuki Koga, Shinji Kiuchi, Kenji Suzuki, Yoshinori Itai, Jun Masumoto, Ichiro Sekiya.. Projected cartilage area ratio determined by 3D MRI analysis: a validation of a novel technique to evaluate articular cartilage.. 13th International Workshop on Osteoarthritis Imaging 2019.06.26 Charlottetown, Canada

  10. Yoshihisa Kushida, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Quantification Of Cartilage Volume By 3D Color Optical Coherence Tomography In A Meniscectomized Rat Model.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.05 Austin,USA

  11. Yoshihisa Kushida, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Use Of 3D MRI And 3D T2 Mapping Images For Evaluation Of The Natural Course Of Cartilage Repair In The Knees Of Micromini Pigs.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.05 Austin,USA

  12. Yuji Kohno, Mitsuru Mizuno, Otabe Koji, Nobutake Ozeki, Hisako Katano, Keiichiro Komori, Kunikazu Tsuji, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Hideyuki Kog, Ichiro Sekiya.. Yields Of MSCs From Synovial Fluid Reflect Yields Of MSCs From The Synovium Of RA Knees.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.05 Austin,USA

  13. Naoto Watanabe, Nobutake Ozeki, Mitsuru Mizuno, Keiichiro Komori, Yuji Kohno, Hisako Katano, Koji Otabe, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Quantitative Analysis Of Mesenchymal Stem Cells (MSCs) In Synovial Fluid Two Weeks After Synovial Removal And Meniscus Repair, Followed By Transplantation Of Synovial MSCs.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.05 Austin,USA

  14. Naoto Watanabe, Mitsuru Mizuno, Junpei Matsuda, Naoko Nakamura, Koji Otabe, Hisako Katano, Nobutake Ozeki, Yuji Kohno, Tsuyoshi Kimura, Kunikazu Tsuji, Hideyuki Koga, Akio Kishida, Ichiro Sekiya.. Comparison Of Decellularized Meniscus By High Hydrostatic Pressure With Freeze-thawed Meniscus.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.05 Austin,USA

  15. Mitsuru Mizuno, Hisako Katano, Yuri Shimozaki, Sho Sanami, Koji Otabe, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Time Lapse Imaging Analysis On Colony Proliferation Process Of Primary Synovial Mscs.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.05 Austin,USA

  16. So Suzuki, Mitsuru Mizuno, Yoshihisa Kushida, Yuji Kohno, Nobutake Ozeki, Koji Otabe, Shizuko Ichinose, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Morphological Alterations Of Synovial Mesenchymal Stem Cells During Adhesion To The Meniscus.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.05 Austin,USA

  17. Ryota Fujisawa, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Shizuka Fujii, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Cryopreservation In 95% Serum With 5% Dmso Maintained Colony Formation And Chondrogenic Abilities In Human Synovial Mesenchymal Stem Cells.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.03 Austin,USA

  18. So Suzuki, Nobutake Ozeki, Yuji Kohno, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Keniji Suzuki, Yoshinori Itai, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya.. Medial Meniscus Extrusion (MME) Area And MME Volume Determined By 3D-MRI Are More Sensitive Than Mme Distance Determined By 2D-MRI For Evaluating Cartilage Loss In Knees With Medial Meniscus Degenerative Tears.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.03 Austin,USA

  19. Hayato Aoki, Nobutake Ozeki, Akinobu Hyodo, So Suzuki, Yoshihisa Kushida, Naoto Watanabe, Yuji Kohno, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Kenji Suzuki, Yoshinori Itai, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya.. Whole Image Of Discoid Lateral Meniscus Analyzed By 3d Mri.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.03 Austin,USA

  20. Kiyotaka Horiuchi, Hideyuki Koga, Mitsuru Mizuno, Hisako Katano, Keiichiro Komori, Koji Otabe, Shizuka Fujii, Nobutake Ozeki, Tsujii Kunikazu, Ichiro Sekiya.. Determining The Optimum Initial Cell Density That Yields The Highest Number Of Mesenchymal Stem Cells Per Dish.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.03 Austin,USA

  21. Rei Kubota, Hideyuki Koga, Nobutake Ozeki, Yuji Kohno, Junpei Matsuda, Yoshihisa Kushida, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Ichiro Sekiya.. Influence Of Knee Flexion Angle On The Biomechanical Effect Of Centralization For Extruded Lateral Meniscus. Orthopaedic Research Society 2019 Annual Meeting 2019.02.02 Austin,USA

  22. Akinobu Hyodo, Nobutake Ozeki, So Suzuki, Hayato Aoki, Naoto Watanabe, Yoshihisa Kushida, Yuji Kohno, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Kenji Suzuki, Yoshinori Itai, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya.. “Projected Cartilage Area Ratio” By Mri 3d Analysis Detects Decrease Of Cartilage Amount In Several Months In Patients Complaining Knee Pain.. Orthopaedic Research Society 2019 Annual Meeting 2019.02.02 Austin,USA

  23. Naoto Watanabe, Mitsuru Mizuno, Jumpei Matsuda, Naoko Nakamura, Koji Otabe, Hisako Katano, Nobutake Ozeki, Yuji Kono, Tsuyoshi Kimura, Kunikazu Tsuji, Hideyuki Koga, Akio Kishida, Ichiro Sekiya. Can Decellularized Meniscus by High Hydrostatic Pressure be an Alternative to Meniscus Allograft? - Compared with Deep Frozen Meniscus.. Orthopaedic Research Society 2018 Annual Meeting 2018.03.12 New Orleans, USA

  24. Mitsuru Mizuno, Hisako Katano, Yuri Shimozaki, Sho Sanami, Keiichiro Komori, Koji Otabe, Nobutake Ozeki, Kunikazu Tsuji, Koga Hideyuki, Ichiro Sekiya. Image Analysis Method to Predict Cell Proliferation at Early Phase for Autologous Synovial Stem Cell Transplantation. Orthopaedic Research Society 2018 Annual Meeting 2018.03.12 New Orleans, USA

  25. Yoshihisa Kushida, Koichiro Kishima Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Pseudo Color Images and Volume Measurement of Cartilage by Optical Coherence Tomography in a Rat Meniscectomized Model.. Orthopaedic Research Society 2018 Annual Meeting 2018.03.12 New Orleans, USA

  26. Hayato Aoki, Nobutake Ozeki, Kohno yuji, Kushida Yoshihisa, Naoto Watanabe, Akinobu Hyodo, So Suzuki, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Yoshinori Itai, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya.. Mri 3d Analysis For Discoid Lateral Meniscus Of The Knee.. Orthopaedic Research Society 2018 Annual Meeting 2018.03.12 New Orleans, USA

  27. Nobutake Ozeki, Yuji Kohno, Yoshihisa Kushida, Naoto Watanabe, Kenta Katagiri, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Yoshinori Itai, Jun Masumoto, Hideyuki Koga, Tomoyuki Saito, Ichiro Sekiya.. Three-Dimensional MRI, T2 Mapping and Histological Analyses of Meniscus Repair After Transplantation of Synovial Mesenchymal Stem Cells in a Novel Degenerative Meniscus Injury Model in Pig. . Orthopaedic Research Society 2018 Annual Meeting 2018.03.11 New Orleans, USA

  28. So Suzuki, Nobutake Ozeki, Akinobu Hyodo, Hayato Aoki, Yoshihisa Kushida, Naoto Watanabe, Yuji Kohno, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Yoshinori Itai, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya.. "Cartilage Area Ratio"by MRI 3D Analysis Reveals Subtle Change of Cartilage Volume in Middle Aged Patients with Medeal Meniscus Degenerative Tear.. Orthopaedic Research Society 2018 Annual Meeting 2018.03.11 New Orleans, USA

  29. Yuji Kohno, Nobutake Ozeki, Akinobu Hyodo, So Suzuki, Hayato Aoki, Yoshihisa Kushida, Naoto Watanabe, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Yoshinori Itai, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya. Validations for cartilage thickness, cartilage area ratio and meniscus volume in the knee by 3D MRI analysis. Orthopaedic Research Society 2018 Annual Meeting 2018.03.11 New Orleans

  30. Miharu Ochi, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Effects of synovial stem cells and BMP-2 on cartilage formation of tendon.. Orthopaedic Research Society 2018 Annual Meeting 2018.03.11 New Orleans, USA

  31. Ryota Fujisawa, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Shizuka Fujii, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Investigation of Freezing Medium for Synovial Mesenchymal Stem Cells.. Orthopaedic Research Society 2018 Annual Meeting 2018.03.11 New Orleans, USA

  32. Akari Sasaki, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Manabu Mochizuki, Ichiro Sekiya.. Comparison Of Canine Mesenchymal Stem Cells Derived From Synovium, Infrapatellar Fat Pad, Subcutaneous Adipose Tissue And Bone Marrow.. Orthopaedic Research Society 2018 Annual Meeting 2018.03.11 New Orleans, USA

  33. Mana Naritomi, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Shizuka Fujii, Shizuko Ichinose, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Petaloid Recombinant Peptide Constructs the Framework of Cartilage Pellet and Promotes In Vitro Cartilage Formation.. Orthopaedic Research Society 2018 Annual Meeting 2018.03.11 New Orleans, USA

  34. Yuji Kohno, Hideyuki Koga, Nobutake Ozeki, Junpei Matsuda, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Ichiro Sekiya. Biomechanical analysis of meniscus centralization for extruded meniscus after meniscectomy. Orthopaedic Research Society 2018 Annual Meeting 2018.03.11

  35. Kenta Katagiri, Mitsuru Mizuno, Hideyuki Koga, Nobutake Ozeki, Yusuke Nakagawa, Yuji Kono, Koji Otabe, Masafumi Horie, Hisako Katano,Kunikazu Tsuji, Hideo Ono, Takeshi Muneta, Ichiro Sekiya.. Transplantation of Synovial Mesenchymal Stem Cells Enhances the Effect of Cetralization with Suture Anchor and Promotes Meniscus Regeneration for Extruded Meniscus After Partial Meniscectomy in Microminipigs. Orthopaedic Research Society 2017 Annual Meeting 2017.03.22 SanDiego, USA

  36. Yuji Kono, Mitsuru Mizuno, Kenta Katagiri, Koji Otabe, Nobutake Ozeki, Hisako Katao, Keiichiro Komori, Masafuji Horie, Kunikazu Tsuji, Mikio Matsumoto, Haruka Kaeko, Yuji Takazawa, Takeshi Muneta, Ichiro Sekiya.. Harvested cell number varies greater in RA than in OA after a suspended synovium culture. Orthopaedic Research Society 2017 Annual Meeting 2017.03.22 SanDiego, USA

  37. Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yuji Kohno, Shizuka Fujii, Nobutake Ozeki, Masafumi Horie, Kunikazu Tsuji, Takeshi Muneta, Ichiro Sekiya.. Complete Human Serum Maintains Viability and Chondrogenic Potential of Human Synovial Stem Cells: Suitable Condition for Transplantation. Orthopaedic Research Society 2017 Annual Meeting 2017.03.21 SanDiego, USA

  38. Naoto Watanabe, Mitsuru Mizuno, Jumpei Matsuda, Hisako Katano, Nobutake Ozeki, Koji Otabe, Keiichiro Komori, Yuji Kono, Kenta Katagiri, Takeshi Muneta, Ichiro Sekiya.. Decellularization of the meniscus by high hydrostatic pressure: temperature condition for removal of cell debris.. Orthopaedic Research Society 2017 Annual Meeting 2017.03.20 SanDiego, USA

  39. Mana Naritomi, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Shizuka Fujii, Nobutake Ozeki, Masafumi Horie, Kunikazu Tsuji, Takeshi Muneta, Ichiro Sekiya.. Recombinant peptide petaloid pieces enhance in vitro cartilage formation of mesenchymal stem cells. Orthopaedic Research Society 2017 Annual Meeting 2017.03.20 SanDiego, USA

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