Personnel Information

写真a

SUSA Koichiro


Job title

Assistant Professor
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Campus Career 【 display / non-display 】

  • 2014.04
    -
    2014.10
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Project Assistant Professor
  • 2014.11
    -
    2016.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Central Clinical Facilities， Hemopurification， Assistant Professor
  • 2016.04
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Nephrology， Visiting Lecturer
  • 2018.04
    -
    2019.03
    Tokyo Medical and Dental University， (Old Organization)Medical Hospital， Central Clinical Facilities， Hemopurification， Project Assistant Professor
  • 2019.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Nephrology， Assistant Professor
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External Career 【 display / non-display 】

  • 2016.05
    -
    2018.03
    Brigham and Women's Hospital, Harvard Medical School, Renal Division, Visiting Assistant Professor
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Published Papers & Misc 【 display / non-display 】

  1. Nakano Y, Mandai S, Genma T, Akagi Y, Fujiki T, Ando F, Susa K, Mori T, Iimori S, Naito S, Sohara E, Uchida S, Fushimi K, Rai T. Nationwide mortality associated with perioperative acute dialysis requirement in major surgeries. International journal of surgery (London, England). 2022.08; 104 106816. ( PubMed, DOI )

  2. Hara Y, Ando F, Oikawa D, Ichimura K, Yanagawa H, Sakamaki Y, Nanamatsu A, Fujiki T, Mori S, Suzuki S, Yui N, Mandai S, Susa K, Mori T, Sohara E, Rai T, Takahashi M, Sasaki S, Kagechika H, Tokunaga F, Uchida S. LRBA is essential for urinary concentration and body water homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 2022.07; 119 (30): e2202125119. ( PubMed, DOI )

  3. Gupta N, Matsumoto T, Hiratsuka K, Garcia Saiz E, Galichon P, Miyoshi T, Susa K, Tatsumoto N, Yamashita M, Morizane R. Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair. Science translational medicine. 2022.03; 14 (634): eabj4772. ( PubMed, DOI )

  4. Nakano Y, Susa K, Yanagi T, Hiraoka Y, Suzuki T, Mori T, Ando F, Mandai S, Fujiki T, Rai T, Uchida S, Sohara E. Generation of NPHP1 knockout human pluripotent stem cells by a practical biallelic gene deletion strategy using CRISPR/Cas9 and ssODN. In vitro cellular & developmental biology. Animal. 2022.02; 58 (2): 85-95. ( PubMed, DOI )

  5. Nanamatsu A, Mori T, Ando F, Furusho T, Mandai S, Susa K, Sohara E, Rai T, Uchida S. Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A). Hypertension (Dallas, Tex. : 1979). 2021.06; 77 (6): 1953-1963. ( PubMed, DOI )

  6. Takahashi Naohiro, Kikuchi Hiroaki, Usui Ayaka, Furusho Taisuke, Fujimaru Takuya, Fujiki Tamami, Yanagi Tomoki, Matsuura Yoshiaki, Asano Kenichi, Yamamoto Kouhei, Ando Fumiaki, Susa Koichiro, Mandai Shintaro, Mori Takayasu, Rai Tatemitsu, Uchida Shinichi, Arita Makoto, Sohara Eisei. Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney Clinical and Experimental Nephrology. 2021.05; 25 (5): 445-455. ( ichushi )

  7. Fujimaru T, Kawanishi K, Mori T, Mishima E, Sekine A, Chiga M, Mizui M, Sato N, Yanagita M, Ooki Y, Nagahama K, Ohnuki Y, Hamano N, Watanabe S, Mochizuki T, Nagatsuji K, Tanaka K, Tsukamoto T, Tsushima H, Shimamoto M, Tsuji T, Kuyama T, Kawamoto S, Maki K, Katsuma A, Oishi M, Yamamoto K, Mandai S, Kikuchi H, Ando F, Mori Y, Susa K, Iimori S, Naito S, Rai T, Hoshino J, Ubara Y, Miyazaki M, Nagata M, Uchida S, Sohara E. Genetic Background and Clinicopathologic Features of Adult-onset Nephronophthisis. Kidney international reports. 2021.05; 6 (5): 1346-1354. ( PubMed, DOI )

  8. Mori T, Chiga M, Fujimaru T, Kawamoto R, Mandai S, Nanamatsu A, Nomura N, Ando F, Susa K, Sohara E, Rai T, Uchida S. Phenotypic differences of mutation-negative cases in Gitelman syndrome clinically diagnosed in adulthood. Human mutation. 2021.03; 42 (3): 300-309. ( PubMed, DOI )

  9. Takahashi N, Kikuchi H, Usui A, Furusho T, Fujimaru T, Fujiki T, Yanagi T, Matsuura Y, Asano K, Yamamoto K, Ando F, Susa K, Mandai S, Mori T, Rai T, Uchida S, Arita M, Sohara E. Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD<sub>2</sub> in the kidney. Clinical and experimental nephrology. 2021.02; ( PubMed, DOI )

  10. Mandai S, Ando F, Mori T, Susa K, Iimori S, Naito S, Sohara E, Uchida S, Fushimi K, Rai T. Burden of kidney disease on the discrepancy between reasons for hospital admission and death: An observational cohort study. PloS one. 2021; 16 (11): e0258846. ( PubMed, DOI )

  11. Arai Y, Asano K, Mandai S, Ando F, Susa K, Mori T, Nomura N, Rai T, Tanaka M, Uchida S, Sohara E. WNK1-TAK1 signaling suppresses lipopolysaccharide-induced cytokine production and classical activation in macrophages. Biochemical and biophysical research communications. 2020.12; 533 (4): 1290-1297. ( PubMed, DOI )

  12. Furusho T, Sohara E, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Zeniya M, Mori T, Susa K, Isobe K, Nomura N, Yamamoto K, Okado T, Rai T, Uchida S. Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease. Kidney international. 2020.02; ( PubMed, DOI )

  13. Mandai S, Sato H, Iimori S, Naito S, Tanaka H, Ando F, Susa K, Isobe K, Mori T, Nomura N, Sohara E, Okado T, Uchida S, Fushimi K, Rai T. Nationwide in-hospital mortality following major fractures among hemodialysis patients and the general population: An observational cohort study. Bone. 2020.01; 130 115122. ( PubMed, DOI )

  14. Shoda W, Nomura N, Ando F, Tagashira H, Iwamoto T, Ohta A, Isobe K, Mori T, Susa K, Sohara E, Rai T, Uchida S. Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia. PloS one. 2020; 15 (6): e0235360. ( PubMed, DOI )

  15. Matsuura Y, Nomura N, Shoda W, Mori T, Isobe K, Susa K, Ando F, Sohara E, Rai T, Uchida S. Tacrolimus ameliorates the phenotypes of type 4 Bartter syndrome model mice through activation of sodium-potassium-2 chloride cotransporter and sodium-chloride cotransporter. Biochemical and biophysical research communications. 2019.09; 517 (2): 364-368. ( PubMed, DOI )

  16. Fujiki T, Ando F, Murakami K, Isobe K, Mori T, Susa K, Nomura N, Sohara E, Rai T, Uchida S. Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation. Scientific reports. 2019.06; 9 (1): 9245. ( PubMed, DOI )

  17. Yoshida S, Araki Y, Mori T, Sasaki E, Kasagi Y, Isobe K, Susa K, Inoue Y, Bomont P, Okado T, Rai T, Uchida S, Sohara E. Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo. Clinical and experimental nephrology. 2018.12; 22 (6): 1251-1257. ( PubMed, DOI )

  18. Yoshida Sayaka, Araki Yuya, Mori Takayasu, Sasaki Emi, Kasagi Yuri, Isobe Kiyoshi, Susa Koichiro, Inoue Yuichi, Bomont Pascale, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi, Sohara Eisei. KLHL3の発現低下はcullin 3のin vivoでの変異によって引き起こされる偽性低アルドステロン症II型の病態発生に関与する(Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo) Clinical and Experimental Nephrology. 2018.12; 22 (6): 1251-1257. ( ichushi )

  19. Lemos DR, McMurdo M, Karaca G, Wilflingseder J, Leaf IA, Gupta N, Miyoshi T, Susa K, Johnson BG, Soliman K, Wang G, Morizane R, Bonventre JV, Duffield JS. Interleukin-1β Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis. Journal of the American Society of Nephrology : JASN. 2018.06; 29 (6): 1690-1705. ( PubMed, DOI )

  20. Gupta N, Susa K, Yoda Y, Bonventre JV, Valerius MT, Morizane R. CRISPR/Cas9-based Targeted Genome Editing for the Development of Monogenic Diseases Models with Human Pluripotent Stem Cells. Current protocols in stem cell biology. 2018.05; 45 (1): e50. ( PubMed, DOI )

  21. Susa K, Sohara E, Takahashi D, Okado T, Rai T, Uchida S. WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3. Biochemical and biophysical research communications. 2017.09; 491 (3): 727-732. ( PubMed, DOI )

  22. Gupta N, Susa K, Morizane R. Regenerative Medicine, Disease Modeling, and Drug Discovery in Human Pluripotent Stem Cell-derived Kidney Tissue. European Medical Journal. Reproductive health. 2017.08; 3 (1): 57-67. ( PubMed )

  23. Sasaki E, Susa K, Mori T, Isobe K, Araki Y, Inoue Y, Yoshizaki Y, Ando F, Mori Y, Mandai S, Zeniya M, Takahashi D, Nomura N, Rai T, Uchida S, Sohara E. <i>KLHL3</i> Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3. Molecular and cellular biology. 2017.04; 37 (7): ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Navin R. Gupta, Takuya Matsumoto, Ken Hiratsuka, Pierre Galichon, Tomoya Miyoshi, Koichiro Susa, Narihito Tatsumoto, Michifumi Yamashita, Ryuji Morizane.. Modeling Kidney Injury and Repair in Kidney Organoids Reveals an Intrinsic Repair Mechanism.. The 54th Annual Meeting of American Society of Nephrology 2022.11 WEB

  2. Koichiro Susa, Akitoshi Tamura, Pierre Galichon, Navin R. Gupta, Takuya Matsumoto, Tomoya Miyoshi, Venkata Sabbisetti, Joseph V. Bonventre, Ryuji Morizane.. A Drug-Specific Nephrotoxicity Prediction System Using Kidney Organoids.. The 52nd Annual Meeting of American Society of Nephrology. 2019.11.08 Washington DC

  3. Takuya Fujimaru, Takayasu Mori, Michio Nagata, Shintaro Mandai, Motoko Chiga, Hiroaki Kikuchi, Fumiaki Ando, Yutaro Mori, Koichiro Susa, Kiyoshi Isobe, Soichiro Iimori, Naohiro Nomura, Shotaro Naito, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara.. Tubular Basement Membrane Duplication and Cell Interposition Are Distinctive Histological Findings in the Adult Patients Genetically Diagnosed with Nephronophthisis-Related Ciliopathies.. The 52nd Annual Meeting of American Society of Nephrology. 2019.11.08 Washington DC

  4. Taisuke Furusho, Shintaro Mandai, Hiroaki Kikuchi, Naohiro Takahashi, Takuya Fujimaru, Hiroko Hashimoto, Yohei Arai, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Kiyoshi Isobe, Naohiro Nomura, Tomokazu Okado, Tatemitsu Rai, Kohei Yamamoto, Shinichi Uchida, Eisei Sohara.. Renal TNF α Activates WNK Phosphorylation Cascade and Contributes to Salt-Sensitive Hypertension in CKD.. The 52nd Annual Meeting of American Society of Nephrology. 2019.11.08 Washington DC

  5. Tamami Fujiki, Fumiaki Ando, Shintaro Mandai, Kiyoshi Isobe, Takayasu Mori, Koichiro Susa, Naohiro Nomura, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida.. Tolvaptan and Bardoxolone Methyl Synergistically Activate the Nrf2/ HO-1 Pathway.. The 52nd Annual Meeting of American Society of Nephrology. 2019.11.08 Washington DC

  6. Naohiro Takahashi, Hiroaki Kikuchi, Makoto Arita, Fumiaki Ando, Shintaro Mandai, Kiyoshi Isobe, Koichiro Susa, Takayasu Mori, Naohiro Nomura, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara.. 12/15-Lipoxygenase Knockout Mice Exhibit a Resistance to Kidney Damage in CKD.. The 52nd Annual Meeting of American Society of Nephrology. 2019.11.08 Washington DC

  7. Navin R. Gupta, Ken Hiratsuka, Tomoya Miyoshi, Koichiro Susa, Narihito Tatsumoto, Michifumi Yamashita, Ryuji Morizane.. Fibrotic Kidney Organoids and Human CKD Samples Demonstrate Loss of Homologous Recombination as a Critical Mediator of Maladaptive Repair. The 52nd Annual Meeting of American Society of Nephrology.. The 52nd Annual Meeting of American Society of Nephrology. 2019.11.08 Washington DC

  8. Fumiaki Ando, Naofumi Yui, Shintaro Mandai, Kiyoshi Isobe, Takayasu Mori, Koichiro Susa, Naohiro Nomura, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida.. Derivatives of FMP-API-1/27 Robustly Activate AQP2 Water Channels Independently of Vasopressin.. The 52nd Annual Meeting of American Society of Nephrology. 2019.11.07 Washington DC

  9. Fujiki T, Ando F, Isobe K, Mori T, Susa K, Nomura N, Sohara E, Rai T, Uchida S.. Tolvaptan Activates Nrf2/HO-1 Pathway Through PERK Phosphorylation. The 51st Annual Meeting of American Society of Nephrology 2018.10.27 San Diego

  10. Takahashi N, Kikuchi H, Ishihara T, Arita M, Furusho T, Ando F, Mori T, Isobe K, Susa K, Nomura N, Rai T, Uchida S, Sohara E.. Amelioration of Renal Fibrosis and Tubulointerstitial Damage in Fat-1 Transgenic CKD Mice by Compensation of Decreased Omega-3 Fatty Acids in the Kidney. The 51st Annual Meeting of American Society of Nephrology 2018.10.27 San Diego

  11. Fujimaru T, Mori T, Mandai S, Chiga M, Kikuchi H, Ando F, Mori Y, Susa K, Isobe K, Iimori S, Nomura N, Naito S, Okado T, Rai T, Nagatsuji K, Nagahama K, Mishima E, Mochizuki T, Sekine A, Hoshino J, Ubara Y, Uchida S, Sohara E.. Genomic Background of Adults with Suspected Ciliopathy on Renal Biopsy. The 51st Annual Meeting of American Society of Nephrology 2018.10.26 San Diego

  12. Tamura A, Susa K, Galichon P, Gupta NR, Miyoshi T, Sabbisetti V, Bonventre JV, Morizane R.. Kidney Organoids for Improved Prediction of Human Nephrotoxicity. The 51st Annual Meeting of American Society of Nephrology 2018.10.25 San Diego

  13. Gupta NR, Garcia E, Miyoshi T, Galichon P, Susa K, Walter LD, Epstein CB, Bonventre JV, Morizane R.. Human Kidney Organoids Model Tubular Injury and Maladaptive Repair with Interstitial Fibrosis In Vitro. The 51st Annual Meeting of American Society of Nephrology 2018.10.25 San Diego

  14. Susa Koichiro, Sohara Eisei, Takahashi Daiei, Rai Tatemitsu, Uchida Shinichi. The Major Contribution of WNK4 to the Pathogenesis of Pseudohypoaldosteronism Type II (PHAII) Caused by the KLHL3 Mutation R528H. The 48th Annual Meeting of American Society of Nephrology 2015.11.05 San Diego

  15. Koichiro Susa, Eisei Sohara, Tatemitsu Rai, Moko Zeniya, Yutaro Mori, Takayasu Mori, Motoko Chiga, Daiei Takahashi, Yuichi Inoue, Kiyoshi Isobe, Naoki Takeda, Sei Sasaki, Shinichi Uchida. Molecular Pathogenesis of PHAII in KLHL3R528H/+ Knock-In Mice. The 47th Annual Meeting of American Society of Nephrology 2014.11.15 Philadelphia

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