Conference Activities & Talks -

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  1. Seiya Oba, Tadashi Hosoya, Daisuke Kawata, Yoji Komiya, Hideyuki Iwai, Ryuji Koike, Shinsuke Yasuda. Iguratimod, a Promising Therapeutic Agent for COVID-19 with Attenuating Excessive Inflammation in Mouse Models. The 26th Asia-Pacific League of Associations for Rheumatology Congress (APLAR2024) 2024.09.25

  2. Seiya Oba, Tadashi Hosoya, Daisuke Kawata, Yoji Komiya, Hideyuki Iwai, Ryuji Koike, Shinsuke Yasuda. Iguratimod, a Promising Therapeutic Agent for COVID-19 with Attenuating Excessive Inflammation in Mouse Models. The 26th Asia-Pacific League of Associations for Rheumatology Congress (APLAR2024) 2024.09.25

  3. KOMIYA Yoji, KAMIYA Mari, HOSOYA Tadashi, OBA Seiya, IWAI Hideyuki, MIYAMOTO Sho, KANNO Takayuki, AINAI Akira, SUZUKI Tadaki, HASEGAWA Hideki, YASUDA Shinsuke. Inhibition of FAS-mediated necroptosis in alveolar epithelial cell suppresses lung injury and subsequent inflammasome activation in murine COVID-19 model.. 日本免疫学会総会・学術集会記録(CD-ROM) 2024.01.17

  4. KOMIYA Yoji, KAMIYA Mari, HOSOYA Tadashi, OBA Seiya, IWAI Hideyuki, MIYAMOTO Sho, KANNO Takayuki, AINAI Akira, SUZUKI Tadaki, HASEGAWA Hideki, YASUDA Shinsuke. Inhibition of FAS-mediated necroptosis in alveolar epithelial cell suppresses lung injury and subsequent inflammasome activation in murine COVID-19 model.. 日本免疫学会総会・学術集会記録(CD-ROM) 2024.01.17

  5. Komiya Yoji, Kamiya Mari, Hosoya Tadashi, Oba Seiya, Kawata Daisuke, Iwai Hideyuki, Miyamoto Sho, Kanno Takayuki, Ainai Akira, Suzuki Tadaki, Hasegawa Hideki, Yasuda Shinsuke. 肺胞上皮細胞におけるFASを介したネクロプトーシスの抑制はCOVID-19マウスモデルにおける肺傷害とその後のインフラマソーム活性化を抑制する(Inhibition of FAS-mediated necroptosis in alveolar epithelial cell suppresses lung injury and subsequent inflammasome activation in murine COVID-19 model). 日本免疫学会総会・学術集会記録 2023.12.01

  6. Seiya Oba, Tadashi Hosoya, Yoji Komiya, Daisuke Kawata, Mari Kamiya, Hideyuki Iwai, Sho Miyamoto, Takayuki Kanno, Tobiume Minoru, Akira Ainai, Tadaki Suzuki, Hideki Hasegawa, Shinsuke Yasuda. The Underlying Mechanisms of Obesity-Related COVID-19 Exacerbations. the 23rd Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2023) 2023.06.20

  7. Seiya Oba, Tadashi Hosoya, Yoji Komiya, Daisuke Kawata, Mari Kamiya, Hideyuki Iwai, Sho Miyamoto, Takayuki Kanno, Tobiume Minoru, Akira Ainai, Tadaki Suzuki, Hideki Hasegawa, Shinsuke Yasuda. The Underlying Mechanisms of Obesity-Related COVID-19 Exacerbations. the 23rd Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2023) 2023.06.20

  8. H. Baba, T. Sugihara, T. Ishizaki, M. Nomura, T. Hosoya, M. Kamiya, T. Matsumoto, K. Kubo, F. Hirano, N. Miyasaka, M. Kojima, S. Yasuda, M. Harigai. AB0219 LONG-TERM OUTCOMES OF METHOTREXATE IN ELDERLY-ONSET RA IMPLEMENTING THE TREAT-TO-TARGET STRATEGY. The EULAR 2023 Congress 2023.05.30

  9. H. Baba, T. Sugihara, T. Ishizaki, M. Nomura, T. Hosoya, M. Kamiya, T. Matsumoto, K. Kubo, F. Hirano, N. Miyasaka, M. Kojima, S. Yasuda, M. Harigai. AB0219 LONG-TERM OUTCOMES OF METHOTREXATE IN ELDERLY-ONSET RA IMPLEMENTING THE TREAT-TO-TARGET STRATEGY. The EULAR 2023 Congress 2023.05.30

  10. Yoji Komiya, Tadashi Hosoya, Seiya Oba, Daisuke Kawata, Mari Kamiya, Hideyuki Iwai, Sho Miyamoto, Takayuki Kanno, Tobiume Minoru, Akira Ainai, Tadaki Suzuki, Hideki Hasegawa, Shinsuke Yasuda. Inhibition of FAS-mediated alveolar epithelial cell death suppresses lung injury and subsequent inflammasome activation in murine COVID-19 model.. The 2nd International Symposium of Clinical Immunology 2023.05.23

  11. Yoji Komiya, Tadashi Hosoya, Seiya Oba, Daisuke Kawata, Mari Kamiya, Hideyuki Iwai, Sho Miyamoto, Takayuki Kanno, Tobiume Minoru, Akira Ainai, Tadaki Suzuki, Hideki Hasegawa, Shinsuke Yasuda. Inhibition of FAS-mediated alveolar epithelial cell death suppresses lung injury and subsequent inflammasome activation in murine COVID-19 model.. The 2nd International Symposium of Clinical Immunology 2023.05.23

  12. Yoji Komiya, Tadashi Hosoya, Seiya Oba, Daisuke Kawata, Mari Kamiya, Hideyuki Iwai, Sho Miyamoto, Takayuki Kanno, Tobiume Minoru, Akira Ainai, Tadaki Suzuki, Hideki Hasegawa, Shinsuke Yasuda. Inhibition of FAS-mediated alveolar epithelial cell death suppresses lung injury and subsequent inflammasome activation in murine COVID-19 model.. The 2nd International Symposium of Clinical Immunology 2023.05.19

  13. Yoji Komiya, Tadashi Hosoya, Seiya Oba, Daisuke Kawata, Mari Kamiya, Hideyuki Iwai, Sho Miyamoto, Takayuki Kanno, Tobiume Minoru, Akira Ainai, Tadaki Suzuki, Hideki Hasegawa, Shinsuke Yasuda. Inhibition of FAS-mediated alveolar epithelial cell death suppresses lung injury and subsequent inflammasome activation in murine COVID-19 model.. The 2nd International Symposium of Clinical Immunology 2023.05.19

  14. HOSOYA Tadashi, HOSOYA Tadashi, OBA Seiya, OBA Seiya, KOMIYA Yoji, KOMIYA Yoji, KAWATA Daisuke, KAMIYA Mari, IWAI Hideyuki, IWAI Hideyuki, MIYAMOTO Sho, KANNO Takayuki, AINAI Akira, SUZUKI Tadaki, HASEGAWA Hideki, YASUDA Shinsuke. The underlying mechanism of the deterioration in obese patients with COVID-19. 日本免疫学会総会・学術集会記録(CD-ROM) 2022.12.09

  15. BABA Hiroyuki, HOSOYA Tadashi, KONDO Yuma, ISHIDA Ryosuke, HATSUZAWA Saki, KAGECHIKA Hiroyuki, YASUDA Shinsuke. Anti-inflammatory effects of novel NF-κB inhibitory compounds in two inflammatory animal models. 日本免疫学会総会・学術集会記録(CD-ROM) 2022.12.09

  16. BABA Hiroyuki, HOSOYA Tadashi, KONDO Yuma, ISHIDA Ryosuke, HATSUZAWA Saki, KAGECHIKA Hiroyuki, YASUDA Shinsuke. Anti-inflammatory effects of novel NF-κB inhibitory compounds in two inflammatory animal models. 日本免疫学会総会・学術集会記録(CD-ROM) 2022.12.09

  17. HOSOYA Tadashi, HOSOYA Tadashi, OBA Seiya, OBA Seiya, KOMIYA Yoji, KOMIYA Yoji, KAWATA Daisuke, KAMIYA Mari, IWAI Hideyuki, IWAI Hideyuki, MIYAMOTO Sho, KANNO Takayuki, AINAI Akira, SUZUKI Tadaki, HASEGAWA Hideki, YASUDA Shinsuke. The underlying mechanism of the deterioration in obese patients with COVID-19. 日本免疫学会総会・学術集会記録(CD-ROM) 2022.12.09

  18. Baba Hiroyuki, Hosoya Tadashi, Kondo Yuma, Ishida Ryosuke, Hatsuzawa Saki, Kagechika Hiroyuki, Yasuda Shinsuke. サイトカインとケモカイン-1　二つの炎症性動物モデルにおける新規NF-κB阻害化合物の抗炎症作用(Cytokines and Chemokines-1　Anti-inflammatory effects of novel NF-κB inhibitory compounds in two inflammatory animal models). 日本免疫学会総会・学術集会記録 2022.11.01

  19. Hosoya Tadashi, Oba Seiya, Komiya Yoji, Kawata Daisuke, Kamiya Mari, Iwai Hideyuki, Miyamoto Sho, Kanno Takayuki, Ainai Akira, Suzuki Tadaki, Hasegawa Hideki, Yasuda Shinsuke. 感染と免疫II　COVID-19の肥満患者における悪化の根本的なメカニズム(Infection and Immunity II　The underlying mechanism of the deterioration in obese patients with COVID-19). 日本免疫学会総会・学術集会記録 2022.11.01

  20. S. Oba, T. Hosoya, D. Kawata, W. Lee, M. Kamiya, Y. Komiya, H. Iwai, Y. Nukui, S. Tohda, S. Yasuda. SARS-CoV-2 INFECTION CAUSED THROMBOSIS IN THE LUPUS MODEL WITH ANTIPHOSPHOLIPID ANTIBODY, WHEREAS COVID-19 ASSOCIATED THROMBOSIS WAS IRRELEVANT IN PATIENTS WITH POSITIVE ANTIPHOSPHOLIPID ANTIBODY. The EULAR 2022 Congress 2022.05.23

  21. T. Sugihara, T. Ishizaki, H. Baba, T. Matsumoto, K. Kubo, M. Kamiya, F. Hirano, T. Hosoya, M. Kojima, N. Miyasaka, M. Harigai. POS0522 ASSOCIATED FACTORS WITH PHYSICAL DYSFUNCTION OF ELDERLY-ONSET RHEUMATOID ARTHRITIS TREATED WITH A TREAT-TO-TARGET STRATEGY. The EULAR 2022 Congress 2022.05.23

  22. T. Sugihara, T. Ishizaki, H. Baba, T. Matsumoto, K. Kubo, M. Kamiya, F. Hirano, T. Hosoya, M. Kojima, N. Miyasaka, M. Harigai. POS0522 ASSOCIATED FACTORS WITH PHYSICAL DYSFUNCTION OF ELDERLY-ONSET RHEUMATOID ARTHRITIS TREATED WITH A TREAT-TO-TARGET STRATEGY. The EULAR 2022 Congress 2022.05.23

  23. S. Oba, T. Hosoya, D. Kawata, W. Lee, M. Kamiya, Y. Komiya, H. Iwai, Y. Nukui, S. Tohda, S. Yasuda. SARS-CoV-2 INFECTION CAUSED THROMBOSIS IN THE LUPUS MODEL WITH ANTIPHOSPHOLIPID ANTIBODY, WHEREAS COVID-19 ASSOCIATED THROMBOSIS WAS IRRELEVANT IN PATIENTS WITH POSITIVE ANTIPHOSPHOLIPID ANTIBODY. The EULAR 2022 Congress 2022.05.23

  24. Seiya Oba, Tadashi Hosoya, Shinsuke Yasuda. Arterial and venous thrombosis complicated in COVID-19; a retrospective single center analysis in Japan. The 50th Annual Meeting of the Japanese Society for Immunology 2021.12.09

  25. HOSOYA Tadashi, TAGAWA Yasuhiro, BABA Hiroyuki, NODA Seiji, YASUDA Shinsuke. The active cyclin dependent kinase 4 and 6 contributed in the MMP-1/3 productions by stabilizing JUN in rheumatoid arthritis synovial fibroblasts. 日本免疫学会総会・学術集会記録(CD-ROM) 2021.12.08

  26. NODA Seiji, HOSOYA Tadashi, TAGAWA Yasuhiro, YASUDA Shinsuke. Remarkable osteogenic and chondrogenic potentials in CD34<sup>+</sup> THY1<sup>+</sup> synovial fibroblast subset. 日本免疫学会総会・学術集会記録(CD-ROM) 2021.12.08

  27. NODA Seiji, HOSOYA Tadashi, TAGAWA Yasuhiro, YASUDA Shinsuke. Remarkable osteogenic and chondrogenic potentials in CD34<sup>+</sup> THY1<sup>+</sup> synovial fibroblast subset. 日本免疫学会総会・学術集会記録(CD-ROM) 2021.12.08

  28. HOSOYA Tadashi, TAGAWA Yasuhiro, BABA Hiroyuki, NODA Seiji, YASUDA Shinsuke. The active cyclin dependent kinase 4 and 6 contributed in the MMP-1/3 productions by stabilizing JUN in rheumatoid arthritis synovial fibroblasts. 日本免疫学会総会・学術集会記録(CD-ROM) 2021.12.08

  29. Tadashi Hosoya, Yasuhiro Tagawa, Hiroyuki Baba, Seiji Noda, Shinsuke Yasuda. Cyclin Dependent Kinase 4 and 6 Determine the Cytokine Responsiveness by Stabilizing JUN in Rheumatoid Arthritis Synovial Fibroblasts.. ACR Convergence 2021 2021.11.06

  30. Noda Seiji, Hosoya Tadashi, Tagawa Yasuhiro, Yasuda Shinsuke. CD34+THY1+滑膜線維芽細胞サブセットにおける著明な骨形成能と軟骨形成能(Remarkable osteogenic and chondrogenic potentials in CD34+ THY1+ synovial fibroblast subest). 日本免疫学会総会・学術集会記録 2021.11.01

  31. Oba Seiya, Hosoya Tadashi, Yasuda Shinsuke. COVID-19に合併した動脈および静脈血栓症　日本における後向き単施設解析(Arterial and venous thrombosis complicated in COVID-19: a retrospective single center analysis in Japan). 日本免疫学会総会・学術集会記録 2021.11.01

  32. Hosoya Tadashi, Tagawa Yasuhiro, Baba Hiroyuki, Noda Seiji, Yasuda Shinsuke. 関節リウマチ滑膜線維芽細胞においてサイクリン依存性キナーゼ4および6の活性化はJUNを安定化させることによりMMP-1/3産生に寄与している(The active cyclin dependent kinase 4 and 6 contributed in the MMP-1/3 productions by stabilizing JUN in rheumatoid arthritis synovial fibroblasts). 日本免疫学会総会・学術集会記録 2021.11.01

  33. Tadashi Hosoya, Hiroyuki Baba, Shinsuke Yasuda, Maripat Corr. Novel compound that impacts migration and chemokine production via NFkB suppressing activity. 日本リウマチ学会総会 International Concurrent Workshop 2021.04.28

  34. Identification of Small Molecules with Efficacy as Steroid Sparing Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-like Synoviocytes. ACR Convergence 2020 2020.10.01

  35. Three Year Outcomes of Patients with Elderly-Onset Rheumatoid Arthritis Treated with a Therapeutic Strategy Targeting Low Disease Activity, and Impact of Adverse Events on Physical Function. 2018.09.01

  36. Oku Kenji, Atsumi Tatsuya, Akiyama Yuji, Amano Hirofumi, Azuma Naoto, Bohgaki Toshiyuki, Funakubo Asanuma Yu, Horita Tetsuya, Hosoya Tadashi, Ichinose Kunihiro, Kato Masaru, Katsumata Yasuhiro, Kawaguchi Yasushi, Kawakami Atsushi, Koga Tomohiro, Kohsaka Hitoshi, Kondo Yuya, Kubo Kanae, Kuwana Masataka, Mimori Akio, Mimori Tsuneyo, Mimura Toshihide, Murakami Kosaku, Nakano Kazuhisa, Nakayamada Shingo, Ogishima Hiroshi, Ohmura Kazumasa, Saito Kazuyoshi, Sano Hajime, Shibuya Mihoko, Takahashi Yuko, Takasaki Yoshinari, Takeuchi Tsutomu, Tamura Naoto, Tanaka Yoshiya, Tsuboi Hiroto, Tsunoda Shinichiro, Yukawa Naoichiro, Yamakawa Noriyuki, Yamamoto Kazuhiko, Sumida Takayuki. Systemic Lupus International Collaborating Clinics(SLICC)によって確立された全身性エリテマトーデスの代替分類基準の評価(Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics(SLICC)). Modern Rheumatology 2018.07.01

  37. CORR Maripat, WOLLER Sarah, HOSOYA Tadashi, HAYASHI Tomoko, MESSER Karen, PU Minya, SHUKLA Nikula, COTTAM Howard, YAKSH Tony, CARSON Dennis. Paradoxical Modulation Strategies for Systemic Autoimmune Diseases. 日本免疫学会総会・学術集会記録(CD-ROM) 2017.12.12

  38. CORR Maripat, WOLLER Sarah, HOSOYA Tadashi, HAYASHI Tomoko, MESSER Karen, PU Minya, SHUKLA Nikula, COTTAM Howard, YAKSH Tony, CARSON Dennis. Paradoxical Modulation Strategies for Systemic Autoimmune Diseases. 日本免疫学会総会・学術集会記録(CD-ROM) 2017.12.12

  39. Corr Maripat, Woller Sarah, Hosoya Tadashi, Hayashi Tomoko, Messer Karen, Pu Minya, Shukla Nikula, Cottam Howard, Yaksh Tony, Carson Dennis. 全身性免疫疾患　全身性自己免疫疾患に対する奇異な制御法(Systemic immune diseases　Paradoxical Modulation Strategies for Systemic Autoimmune Diseases). 日本免疫学会総会・学術集会記録 2017.12.01

  40. Tadashi Hosoya, Fumi Sato-Kaneko, Alast Ahmadi, Shiyin Yao, Fitzgerald S Lao, Takaji Matsutani, Dennis A Carson, Tomoko Hayashi. Immunotherapy with a phospholipid-conjugated TLR7 ligand prevents lung metastasis. La Jolla immunology conference 2017.10.18

  41. Tadashi Hosoya, Fumi Kaneko, Alast Ahmadiiveli, Julissa Trahan, Shiyin Yao, Dennis A Carson, Tomoko Hayashi. Immunotherapy with a phospholipid-conjugated TLR7 ligand prevents lung metastasis. The La Jolla Immunology Conference (LJIC) 2017 2017.10.18

  42. Tadashi Hosoya, Fumi Kaneko, Alast Ahmadiiveli, Julissa Trahan, Shiyin Yao, Dennis A Carson, Tomoko Hayashi. Immunotherapy with a phospholipid-conjugated TLR7 ligand prevents lung metastasis. The La Jolla Immunology Conference (LJIC) 2017 2017.10.18

  43. Kusuda Takeshi, Hosoya Tadashi, Mori Takayasu, Ihara Katsuhito, Nishida Hidenori, Chiga Motoko, Sohara Eisei, Rai Tatemitsu, Koike Ryuji, Uchida Shinichi, Kohsaka Hitoshi. SLC12A3ヘテロ接合変異を有する抗SSA抗体陽性患者における後天性Gitelman症候群(Acquired Gitelman Syndrome in an Anti-SSA Antibody-positive Patient with a SLC12A3 Heterozygous Mutation). Internal Medicine 2016.11.01

  44. Hosoya Tadashi, Mizoguchi Fumitaka, Hasegawa Hisanori, Miura Keiko, Koike Ryuji, Kubota Tetsuo, Miyasaka Nobuyuki, Kohsaka Hitoshi. TNFRSF1A遺伝子変異を認めず、トシリズマブ投与が奏効した、腫瘍壊死因子(TNF)受容体関連周期性症候群(TRAPS)の臨床的特徴を示す1症例. Internal Medicine 2015.08.01

  45. Tadashi Hosoya, Kimito Kawahata,Hideyuki Iwai, Hitoshi Kohsaka. Cell cycle regulation therapy, when combined with TNF blockade, exerted significant therapeutic effects even in the late stage of a rheumatoid arthritis model. ACR/ARHP Annual Meeting 2014.11.18 Boston

  46. The Combination Therapy of Cell Cycle Regulation Therapy Combined and TNF Blockade Ameliorated the Established Arthritis.. 2014.10.01

  47. Tadashi Hosoya, Hideyuki Iwai, Yu Yamaguchi, Nobuyuki Miyasaka, Hitoshi Kohsaka. Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression.. 58th Annual General Assembly and Scientific Meeting of the Japan College of Rheumatology 2014.04.24 Tokyo

  48. Hosoya Tadashi, Iwai Hideyuki, Yamaguchi Yu, Miyasaka Nobuyuki, Kohsaka Hitoshi. RA、病因　サイトカインの阻害と併用した細胞周期調節療法は免疫抑制を増強することなく関節炎抑制効果を増強する(RA, pathogenesis　Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression). 日本リウマチ学会総会・学術集会プログラム・抄録集 2014.03.01

  49. Hosoya Tadashi, Iwai Hideyuki, Yamaguchi Yu, Miyasaka Nobuyuki, Kohsaka Hitoshi. 関節リウマチの治療　新しい治療薬　サイトカイン阻害と併用した細胞周期調節療法は免疫抑制を増加させることなく関節炎抑制作用を増強する(Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression). 日本リウマチ学会総会・学術集会プログラム・抄録集 2014.03.01

  50. Hosoya Tadashi, Iwai Hideyuki, Miyasaka Nobuyuki, Kohsaka Hitoshi. サイトカイン遮断を併用した細胞周期調節療法は、免疫抑制増加を伴わずに抗関節炎効果を増強する(Cell cycle regulation therapy combined with cytokine blockade enhances anti-arthritic effects without increase of immune suppression). 日本免疫学会総会・学術集会記録 2013.11.01

  51. Cell Cycle Regulation Therapy Combined With Cytokine Blockade Enhances Anti-Arthritic Effects Without Increase Of Immune Suppression. 2013.10.01

  52. Iwai Hideyuki, Hosoya Tadashi, Takenaka Kenchi, Murakami Yousuke, Miyasaka Nobuyuki, Hitoshi Kohsaka. 関節リウマチの新たな治療と評価　マウスTREM-1リガンドの機能解析およびヒトTREM-1リガンドの同定(Functional analysis of mouse TREM-1 ligand and identification of human TREM-1 ligand). 日本免疫学会総会・学術集会記録 2012.11.01

  53. Treat-to-Target Strategy Aiming At Achievement of Structural and Functional Remission in Patients with Active Elderly-Onset Rheumatoid Arthritis.. 2012.10.01

  54. Hideyuki Iwai, Hosoya Tadashi, Murakami Yousuke, Miyasaka Nobuyuki, Kohsaka Hitoshi. 関節リウマチ　関節炎治療標的としてのB細胞上のTREM-1リガンドの同定(Identification of the TREM-1 ligand on B lymphocytes as a therapeutic target of arthritis). 日本免疫学会総会・学術集会記録 2011.11.01

  55. Kaneko Kayoko, Nanki Toshihiro, Hosoya Tadashi, Mizoguchi Fumitaka, Miyasaka Nobuyuki. 関節リウマチ患者2例におけるエタネルセプトで誘発された壊死性半月体形成性糸球体腎炎(Etanercept-induced necrotizing crescentic glomerulonephritis in two patients with rheumatoid arthritis). Modern Rheumatology 2010.12.01

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