Kikuchi H, Chou CL, Yang CR, Chen L, Jung HJ, Park E, Limbutara K, Carter B, Yang ZH, Kun JF, Remaley AT, Knepper MA. Signaling mechanisms in renal compensatory hypertrophy revealed by multi-omics. Nature communications. 2023.06; 14 (1): 3481. ( PubMed, DOI )

Bingham MA, Neijman K, Yang CR, Aponte A, Mak A, Kikuchi H, Jung HJ, Poll BG, Raghuram V, Park E, Chou CL, Chen L, Leipziger J, Knepper MA, Dona M. Circadian gene expression in mouse renal proximal tubule. American journal of physiology. Renal physiology. 2023.03; 324 (3): F301-F314. ( PubMed, DOI )

Park E, Yang CR, Raghuram V, Deshpande V, Datta A, Poll BG, Leo KT, Kikuchi H, Chen L, Chou CL, Knepper MA. Data resource: vasopressin-regulated protein phosphorylation sites in the collecting duct. American journal of physiology. Renal physiology. 2023.01; 324 (1): F43-F55. ( PubMed, DOI )

Yanagi T, Kikuchi H, Susa K, Takahashi N, Bamba H, Suzuki T, Nakano Y, Fujiki T, Mori Y, Ando F, Mandai S, Mori T, Takeuchi K, Honda S, Torii S, Shimizu S, Rai T, Uchida S, Sohara E. Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression. Genes to cells : devoted to molecular & cellular mechanisms. 2023.01; 28 (1): 5-14. ( PubMed, DOI )

Mehta YR, Lewis SA, Leo KT, Chen L, Park E, Raghuram V, Chou CL, Yang CR, Kikuchi H, Khundmiri S, Poll BG, Knepper MA. "ADPKD-omics": determinants of cyclic AMP levels in renal epithelial cells. Kidney international. 2022.01; 101 (1): 47-62. ( PubMed, DOI )

Chen L, Jung HJ, Datta A, Park E, Poll BG, Kikuchi H, Leo KT, Mehta Y, Lewis S, Khundmiri SJ, Khan S, Chou CL, Raghuram V, Yang CR, Knepper MA. Systems Biology of the Vasopressin V2 Receptor: New Tools for Discovery of Molecular Actions of a GPCR. Annual review of pharmacology and toxicology. 2022.01; 62 595-616. ( PubMed, DOI )

Kikuchi H, Jung HJ, Raghuram V, Leo KT, Park E, Yang CR, Chou CL, Chen L, Knepper MA. Bayesian identification of candidate transcription factors for the regulation of Aqp2 gene expression. American journal of physiology. Renal physiology. 2021.09; 321 (3): F389-F401. ( PubMed, DOI )

Takahashi Naohiro, Kikuchi Hiroaki, Usui Ayaka, Furusho Taisuke, Fujimaru Takuya, Fujiki Tamami, Yanagi Tomoki, Matsuura Yoshiaki, Asano Kenichi, Yamamoto Kouhei, Ando Fumiaki, Susa Koichiro, Mandai Shintaro, Mori Takayasu, Rai Tatemitsu, Uchida Shinichi, Arita Makoto, Sohara Eisei. ALOX15の欠損は腎臓でのPGD2の増加により腎機能障害を改善し線維化を抑制する(Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney) Clinical and Experimental Nephrology. 2021.05; 25 (5): 445-455. ( ichushi )

Fujimaru T, Kawanishi K, Mori T, Mishima E, Sekine A, Chiga M, Mizui M, Sato N, Yanagita M, Ooki Y, Nagahama K, Ohnuki Y, Hamano N, Watanabe S, Mochizuki T, Nagatsuji K, Tanaka K, Tsukamoto T, Tsushima H, Shimamoto M, Tsuji T, Kuyama T, Kawamoto S, Maki K, Katsuma A, Oishi M, Yamamoto K, Mandai S, Kikuchi H, Ando F, Mori Y, Susa K, Iimori S, Naito S, Rai T, Hoshino J, Ubara Y, Miyazaki M, Nagata M, Uchida S, Sohara E. Genetic Background and Clinicopathologic Features of Adult-onset Nephronophthisis. Kidney international reports. 2021.05; 6 (5): 1346-1354. ( PubMed, DOI )

Takahashi N, Kikuchi H, Usui A, Furusho T, Fujimaru T, Fujiki T, Yanagi T, Matsuura Y, Asano K, Yamamoto K, Ando F, Susa K, Mandai S, Mori T, Rai T, Uchida S, Arita M, Sohara E. Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD(2) in the kidney. Clinical and experimental nephrology. 2021.05; 25 (5): 445-455. ( PubMed, DOI )

Furusho T, Sohara E, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Zeniya M, Mori T, Susa K, Isobe K, Nomura N, Yamamoto K, Okado T, Rai T, Uchida S. Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease. Kidney international. 2020.04; 97 (4): 713-727. ( PubMed, DOI )

Sekine A, Hoshino J, Fujimaru T, Suwabe T, Mizuno H, Kawada M, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Mandai S, Chiga M, Kikuchi H, Ando F, Mori T, Sohara E, Uchida S, Sawa N, Takaichi K, Ubara Y. Genetics May Predict Effectiveness of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease. American journal of nephrology. 2020; 51 (9): 745-751. ( PubMed, DOI )

Hiroaki Kikuchi, Emi Sasaki, Naohiro Nomura, Takayasu Mori, Yoji Andrew Minamishima, Yuki Yoshizaki, Naohiro Takahashi, Taisuke Furusho, Yohei Arai, Shintaro Mandai, Takahiro Yamashita, Fumiaki Ando, Yasuhiro Maejima, Kiyoshi Isobe, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara. Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease. Kidney Int.. 2019.01; 95 (1): 123-137. ( PubMed, DOI )

Kikuchi H, Sasaki E, Nomura N, Mori T, Minamishima YA, Yoshizaki Y, Takahashi N, Furusho T, Arai Y, Mandai S, Yamashita T, Ando F, Maejima Y, Isobe K, Okado T, Rai T, Uchida S, Sohara E. Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease Kidney Int.. 2019.01; 95 (1): 123-137.

Sekine A, Fujimaru T, Hoshino J, Suwabe T, Oguro M, Mizuno H, Kawada M, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Mandai S, Chiga M, Kikuchi H, Ando F, Mori T, Sohara E, Uchida S, Sawa N, Takaichi K, Ubara Y. Genotype-Clinical Correlations in Polycystic Kidney Disease with No Apparent Family History. American journal of nephrology. 2019; 49 (3): 233-240. ( PubMed, DOI )

Hashimoto H, Nomura N, Shoda W, Isobe K, Kikuchi H, Yamamoto K, Fujimaru T, Ando F, Mori T, Okado T, Rai T, Uchida S, Sohara E. Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium-chloride cotransporter. Metabolism: clinical and experimental. 2018.08; 85 23-31. ( PubMed, DOI )

Fujimaru T., Mori T., Sekine A., Mandai S., Chiga M., Kikuchi H., Ando F., Mori Y., Nomura N., Iimori S., Naito S., Okado T., Rai T., Hoshino J., Ubara Y., Uchida S., Sohara E.. Kidney enlargement and multiple liver cyst formation implicate mutations in PKD1/2 in adult sporadic polycystic kidney disease CLINICAL GENETICS. 2018.07; 94 (1): 125-131. ( PubMed, DOI )

Mandai S, Mori T, Nomura N, Furusho T, Arai Y, Kikuchi H, Sasaki E, Sohara E, Rai T, Uchida S. WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4. Scientific reports. 2018.06; 8 (1): 9101. ( PubMed, DOI )

Hiroaki Kikuchi, Eiichiro Kanda, Takayasu Mori, Hidehiko Sato, Soichiro Iimori, Naohiro Nomura, Shotaro Naito, Eisei Sohara, Tomokazu Okado, Shinichi Uchida, Kiyohide Fushimi, Tatemitsu Rai. Short-term prognosis of emergently hospitalized dialysis-independent chronic kidney disease patients: A nationwide retrospective cohort study in Japan. PLoS ONE. 2018; 13 (11): e0208258. ( PubMed, DOI )

Ito Y, Sekine A, Takada D, Yabuuchi J, Kogure Y, Ueno T, Sumida K, Yamanouchi M, Hayami N, Suwabe T, Hoshino J, Sawa N, Takaichi K, Kinowaki K, Fujii T, Ohashi K, Kikuchi H, Mandai S, Chiga M, Mori T, Sohara E, Uchida S, Ubara Y. Renal histology and MRI findings in a 37-year-old Japanese patient with autosomal recessive polycystic kidney disease
. Clinical nephrology. 2017.11; 88 (11): 292-297. ( PubMed, DOI )

Shintaro Mandai, Eiichiro Kanda, Soichiro Iimori, Shotaro Naito, Yumi Noda, Hiroaki Kikuchi, Masanobu Akazawa, Katsuyuki Oi, Takayuki Toda, Eisei Sohara, Tomokazu Okado, Sei Sasaki, Tatemitsu Rai, Shinichi Uchida. Association of serum chloride level with mortality and cardiovascular events in chronic kidney disease: the CKD-ROUTE study. Clin. Exp. Nephrol.. 2017.02; 21 (1): 104-111. ( PubMed, DOI )

Kikuchi Hiroaki, Kanda Eiichiro, Mandai Shintaro, Akazawa Masanobu, Iimori Soichiro, Oi Katsuyuki, Naito Shotaro, Noda Yumi, Toda Takayuki, Tamura Teiichi, Sasaki Sei, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi. 低いBMIと血清アルブミン値の組み合わせは慢性腎疾患進行と関連する　chronic kidney-research of outcomes in treatment and epidemiology(CKD-ROUTE)研究(Combination of low body mass index and serum albumin level is associated with chronic kidney disease progression: the chronic kidney disease-research of outcomes in treatment and epidemiology(CKD-ROUTE) study) Clinical and Experimental Nephrology. 2017.02; 21 (1): 55-62. ( ichushi )

Mandai Shintaro, Kanda Eiichiro, Iimori Soichiro, Naito Shotaro, Noda Yumi, Kikuchi Hiroaki, Akazawa Masanobu, Oi Katsuyuki, Toda Takayuki, Sohara Eisei, Okado Tomokazu, Sasaki Sei, Rai Tatemitsu, Uchida Shinichi. 慢性腎疾患における血清塩化物濃度と死亡率および心血管イベントとの関連　CKD-ROUTE研究(Association of serum chloride level with mortality and cardiovascular events in chronic kidney disease: the CKD-ROUTE study) Clinical and Experimental Nephrology. 2017.02; 21 (1): 104-111. ( ichushi )

Mandai Shintaro, Kanda Eiichiro, Iimori Soichiro, Naito Shotaro, Noda Yumi, Kikuchi Hiroaki, Akazawa Masanobu, Oi Katsuyuki, Toda Takayuki, Sohara Eisei, Okado Tomokazu, Sasaki Sei, Rai Tatemitsu, Uchida Shinichi. 慢性腎疾患における血清塩化物濃度と死亡率および心血管イベントとの関連 CKD-ROUTE研究(Association of serum chloride level with mortality and cardiovascular events in chronic kidney disease: the CKD-ROUTE study) Clinical and Experimental Nephrology. 2017.02; 21 (1): 104-111.

Hiroaki Kikuchi, Eiichiro Kanda, Shintaro Mandai, Masanobu Akazawa, Soichiro Iimori, Katsuyuki Oi, Shotaro Naito, Yumi Noda, Takayuki Toda, Teiichi Tamura, Sei Sasaki, Eisei Sohara, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida. Combination of low body mass index and serum albumin level is associated with chronic kidney disease progression: the chronic kidney disease-research of outcomes in treatment and epidemiology (CKD-ROUTE) study. Clin. Exp. Nephrol.. 2016.02; ( PubMed, DOI )

Hiroaki Kikuchi, Takayasu Mori, Tatemitsu Rai, Shinichi Uchida. Acute kidney injury caused by sarcoid granulomatous interstitial nephritis without extrarenal manifestations. CEN Case Rep. 2015.11; 4 (2): 212-217. ( PubMed, DOI )

Hiroaki Kikuchi, Takanobu Yoshimoto, Hiroyuki Tanaka, Kazutaka Tsujimoto, Chisato Yamamura, Yohei Arai, Suguru Hirasawa, Shota Aki, Naoto Inaba, Makoto Aoyagi, Yoshihiro Ogawa, Teiichi Tamura. Periodic hypokalemia associated with cyclic Cushing's syndrome. CEN Case Rep. 2014.05; 3 (1): 80-85. ( PubMed, DOI )

Yohei Arai, Eiichiro Kanda, Hiroaki Kikuchi, Chisato Yamamura, Suguru Hirasawa, Shota Aki, Naoto Inaba, Makoto Aoyagi, Hiroyuki Tanaka, Teiichi Tamura, Sei Sasaki. Decreased mobility after starting dialysis is an independent risk factor for short-term mortality after initiation of dialysis. Nephrology (Carlton). 2014.04; 19 (4): 227-233. ( PubMed, DOI )

Hiroaki Kikuchi, Makoto Aoyagi, Kiyotaka Nagahama, Chisato Yamamura, Yohei Arai, Suguru Hirasawa, Shota Aki, Naoto Inaba, Hiroyuki Tanaka, Teiichi Tamura. IgA-dominant postinfectious glomerulonephritis associated with Escherichia coli infection caused by cholangitis. Intern. Med.. 2014; 53 (22): 2619-2624. ( PubMed )

Hiroaki Kikuchi, Makoto Aoyagi, Kiyotaka Nagahama, Yu Yajima, Chisato Yamamura, Yohei Arai, Suguru Hirasawa, Shota Aki, Naoto Inaba, Hiroyuki Tanaka, Teiichi Tamura. Nephrotic-range proteinuria and interstitial nephritis associated with the use of a topical loxoprofen patch. Intern. Med.. 2014; 53 (11): 1131-1135. ( PubMed )

Kikuchi H, Jung HJ, Knepper MA. . Bayesian Identification of Transcription Factors That Regulate Aqp2 Transcription.. The 54th Annual Meeting of American Society of Nephrology 2021.10.29 Virtual

Kikuchi H, Knepper MA.. Multi-omic Analysis of Mouse Renal Tubule Cell Responses following Unilateral Nephrectomy.. The 54th Annual Meeting of American Society of Nephrology 2021.10.29 Virtual

Kikuchi H, Jung HJ, Knepper MA. . Bayesian Identification of Transcription Factors that Regulate Aqp2 Transcription. . Experimental Biology 2021 2021.04.27 Virtual

Kikuchi H, Jung HJ, Park E, Chen L, Yang CR, Raghuram V, Knepper MA. . Bayesian Identification of Transcription Factors that Regulate Aqp2 Transcription.. The 53th Annual Meeting of American Society of Nephrology 2020.10.22 Virtual

Sohara Eisei, Kikuchi Hiroaki, Uchida Shinichi. 腎機能の再生医療におけるNew Frontiers　慢性腎臓病におけるエネルギー状態感知不全(New Frontiers in Regenerative Medicine of Renal Function　Failure to sense energy depletion in chronic kidney disease). The Journal of Physiological Sciences 2019.06.01

Hiroaki Kikuchi, Eisei Sohara, Naohiro Nomura,Takayasu Mori, Yoji Andrew Minamishima, Naohiro Takahashi, Taisuke Furusho, Fumiaki Ando, Kiyoshi Isobe, Koichiro Susa, Tatemitsu Rai, and Shinichi Uchida. AMPK activation bypassing AMP sensing mechanism is a novel therapeutic strategy for chronic kidney disease. The 8th CKD Frontier Meeting 2019.02.23 Nagoya

Hiroaki Kikuchi, Eiichiro Kanda, Fumiaki Ando, Hidehiko Sato, Kiyoshi Isobe, Takayasu Mori, Soichiro Iimori, Naohiro Nomura, Shotaro Naito, Eisei Sohara, Tomokazu Okado, Shinichi Uchida, Kiyohide Fushimi and Tatemitsu Rai. Association between Body Mass Index and In-hospital Mortality in Emergently Hospitalized Dialysis-Independent CKD Patients; A Nationwide Retrospective Cohort Study in Japan. ISN Frontiers Meetings 2018 2018.02.23 Tokyo, Japan

Hiroaki Kikuchi, Eiichiro Kanda, Fumiaki Ando, Hidehiko Sato, Kiyoshi Isobe, Takayasu Mori, Soichiro Iimori, Naohiro Nomura, Shotaro Naito, Eisei Sohara, Tomokazu Okado, Shinichi Uchida, Kiyohide Fushimi and Tatemitsu Rai. Association between Body Mass Index and In-hospital Mortality in Emergently Hospitalized Dialysis-Independent CKD Patients; A Nationwide Retrospective Cohort Study in Japan. 2017.11.02 New Orleans, LA.

Hiroaki Kikuchi, Naohiro Nomura, Yoji Andrew Minamishima, Tatemitsu Rai, Shinichi Uchida and Eisei Sohara.. Targeted Metabolomic Analysis of Kidney from the Subtotal Nephrectomy Mouse Model of Chronic Kidney Disease. The 49th Annual Meeting of American Society of Nephrology. 2016.11.15 Chicago.

Kikuchi H, Kanda E, Iimori S, Naito S, Sasaki S, Sohara E, Okado T,Rai T,Uchida S. Combination of low body mass index and serum albumin level leads to chronic kidney disease progression: the chronic kidney disease–research of outcomes in treatment and epidemiology study. The 48th Annual Meeting of American Society of Nephrology 2015.11.05 San Diego, USA

Kikuchi H, Kanda E, Mandai S, Akazawa M, Iimori S, Oi K, Toda T, Tamura T, Sasaki S, Okado T, Rai T, Uchida S. Low Serum Albumin and Body Mass Index Predicts Chronic Kidney Disease Progression. The 4th Chronik Kidney Disease Frontier Meeting 2015.02.28 Nagoya