Yusuke Nakagawa, Kunikazu Tsuji, Tomomasa Nakamura, Hiroki Katagiri, Nobutake Ozeki, Mikio Shioda, Jae-Sung An, Ryu Yoshida, Ichiro Sekiya, Hideyuki Koga. Association of Infrapatellar Fat Pad Fibrosis at 3 Months After ACL Reconstruction With Short-term Clinical Outcomes and Inflammatory Cytokine Levels in the Synovial Fluid. Orthop J Sports Med. 2023.04; 11 (4): 23259671231164122. ( PubMed, DOI )

Takanori Wakayama, Yoshitomo Saita, Masashi Nagao, Sayuri Uchino, Sei-Ichi Yoshihara, Kunikazu Tsuji, Hideyuki Koga, Yohei Kobayashi, Hirofumi Nishio, Yasumasa Momoi, Hiroshi Ikeda, Kazuo Kaneko, Muneaki Ishijima. Intra-Articular Injections of the Adipose-Derived Mesenchymal Stem Cells Suppress Progression of a Mouse Traumatic Knee Osteoarthritis Model. Cartilage. 2022.12; 13 (4): 148-156. ( PubMed, DOI )

Shunichi Fujii, Kentaro Endo, Nobutake Ozeki, Yuriko Sakamaki, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Comparison of adhesion of thawed and cultured synovial mesenchymal stem cells to the porcine meniscus and the relevance of cell surface microspike BMC Molecular and Cell Biology. 2022.12; 23 (1): 53. ( PubMed, DOI )

Masaaki Isono, Jun Takeuchi, Ami Maehara, Yusuke Nakagawa, Hiroki Katagiri, Kazumasa Miyatake, Ichiro Sekiya, Hideyuki Koga, Yoshinori Asou, Kunikazu Tsuji. Effect of CD44 signal axis in the gain of mesenchymal stem cell surface antigens from synovial fibroblasts in vitro Heliyon. 2022.10; 8 (10): e10739. ( PubMed, DOI )

Guo Tang, Yoshinori Asou, Etsuko Matsumura, Yusuke Nakagawa, Kazumasa Miyatake, Hiroki Katagiri, Tomomasa Nakamura, Hideyuki Koga, Keiichiro Komori, Ichiro Sekiya, Yoich Ezura, Kunikazu Tsuji. Short cytoplasmic isoform of IL1R1/CD121a mediates IL1β induced proliferation of synovium-derived mesenchymal stem/stromal cells through ERK1/2 pathway. Heliyon. 2022.05; 8 (5): e09476. ( PubMed, DOI )

Hiroki Katagiri, Kaori Nakamura, Takeshi Muneta, Toshifumi Watanabe, Kazumasa Miyatake, Ichiro Sekiya, Hideyuki Koga, Kunikazu Tsuji. Inflammatory and healing environment in synovial fluid after anterior cruciate ligament reconstruction: Granulocytes and endogenous opioids as new targets of postoperative pain. Biochem Biophys Rep. 2021.07; 26 100981. ( PubMed, DOI )

Hiroko Ueki, Hiroki Katagiri, Kunikazu Tsuji, Kazumasa Miyatake, Toshifumi Watanabe, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Effect of transplanted mesenchymal stem cell number on the prevention of cartilage degeneration and pain reduction in a posttraumatic osteoarthritis rat model. J Orthop Sci. 2021.07; 26 (4): 690-697. ( PubMed, DOI )

Kazumasa Kawata, Hideyuki Koga, Kunikazu Tsuji, Kazumasa Miyatake, Yusuke Nakagawa, Takanori Yokota, Ichiro Sekiya, Hiroki Katagiri. Extracellular vesicles derived from mesenchymal stromal cells mediate endogenous cell growth and migration via the CXCL5 and CXCL6/CXCR2 axes and repair menisci. Stem Cell Res Ther. 2021.07; 12 (1): 414. ( PubMed, DOI )

Kiyotaka Horiuchi, Nobutake Ozeki, Kentaro Endo, Mitsuru Mizuno, Hisako Katano, Masako Akiyama, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Thawed cryopreserved synovial mesenchymal stem cells show comparable effects to cultured cells in the inhibition of osteoarthritis progression in rats. Sci Rep. 2021.05; 11 (1): 9683. ( PubMed, DOI )

Horiuchi Kiyotaka, Mizuno Mitsuru, Katano Hisako, Endo Kentaro, Ozeki Nobutake, Tsuji Kunikazu, Koga Hideyuki, Sekiya Ichiro.. Optimal initial cell density that yields the highest number of primary synovial mesenchymal stem cells in a clinical setting. J Med Dent Sci.. 2021.04; 68 17-26.

J-S An, K Tsuji, H Onuma, N Araya, M Isono, T Hoshino, K Inomata, J Hino, M Miyazato, H Hosoda, K Kangawa, Y Nakagawa, H Katagiri, K Miyatake, I Sekiya, T Muneta, H Koga. Inhibition of fibrotic changes in infrapatellar fat pad alleviates persistent pain and articular cartilage degeneration in monoiodoacetic acid-induced rat arthritis model. Osteoarthritis Cartilage. 2021.03; 29 (3): 380-388. ( PubMed, DOI )

Aidehamu Aihemaiti, Naoki Yamamoto, Jinying Piao, Takuya Oyaizu, Hiroki Ochi, Shingo Sato, Atsushi Okawa, Toshio Miyata, Kunikazu Tsuji, Yoichi Ezura, Yoshinori Asou. A novel PAI-1 inhibitor prevents ageing-related muscle fiber atrophy. Biochem Biophys Res Commun. 2021.01; 534 849-856. ( PubMed, DOI )

Yoshihisa Kushida, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Kunikazu Tsuji, Hideyuki Koga, Koichiro Kishima, Yoshio Soma, Ichiro Sekiya. Two- and three-dimensional optical coherence tomography to differentiate degenerative changes in a rat meniscectomy model. J Orthop Res. 2020.12; 38 (12): 2592-2600. ( PubMed, DOI )

Naoto Watanabe, Kentaro Endo, Keiichiro Komori, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Yuji Kohno, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Mesenchymal Stem Cells in Synovial Fluid Increase in Knees with Degenerative Meniscus Injury after Arthroscopic Procedures through the Endogenous Effects of CGRP and HGF. Stem Cell Rev Rep. 2020.12; 16 (6): 1305-1315. ( PubMed, DOI )

So Suzuki, Mitsuru Mizuno, Yuriko Sakamaki, Ayako Mimata, Kentaro Endo, Yuji Kohno, Nobutake Ozeki, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Morphological changes in synovial mesenchymal stem cells during their adhesion to the meniscus. Lab. Invest.. 2020.07; 100 (7): 916-927. ( PubMed, DOI )

Naoko Araya, Kazumasa Miyatake, Kunikazu Tsuji, Hiroki Katagiri, Yusuke Nakagawa, Takashi Hoshino, Hiroaki Onuma, Saisei An, Hirofumi Nishio, Yoshitomo Saita, Ichiro Sekiya, Hideyuki Koga. Intra-articular Injection of Pure Platelet-Rich Plasma Is the Most Effective Treatment for Joint Pain by Modulating Synovial Inflammation and Calcitonin Gene-Related Peptide Expression in a Rat Arthritis Model. Am J Sports Med. 2020.07; 48 (8): 2004-2012. ( PubMed, DOI )

Hiroaki Onuma, Kunikazu Tsuji, Takashi Hoshino, Kei Inomata, Mio Udo, Yusuke Nakagawa, Hiroki Katagiri, Kazumasa Miyatake, Toshifumi Watanabe, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Fibrotic changes in the infrapatellar fat pad induce new vessel formation and sensory nerve fiber endings that associate prolonged pain. J. Orthop. Res.. 2020.06; 38 (6): 1296-1306. ( PubMed, DOI )

Tingting Zhang, Nanako Kawaguchi, Kunikazu Tsuji, Emiko Hayama, Yoshiyuki Furutani, Hisashi Sugiyama, Toshio Nakanishi. Silibinin Upregulates CXCR4 Expression in Cultured Bone Marrow Cells (BMCs) Especially in Pulmonary Arterial Hypertension Rat Model. Cells. 2020.05; 9 (5): 1276. ( PubMed, DOI )

Leyang Li, Hiroyuki Yokoyama, Hidetoshi Kaburagi, Takashi Hirai, Kunikazu Tsuji, Mitsuhiro Enomoto, Yoshiaki Wakabayashi, Atsushi Okawa. Remnant neuromuscular junctions in denervated muscles contribute to functional recovery in delayed peripheral nerve repair. Neural Regen Res. 2020.04; 15 (4): 731-738. ( PubMed, DOI )

Masaki Amemiya, Kunikazu Tsuji, Hiroki Katagiri, Kazumasa Miyatake, Yusuke Nakagawa, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Synovial fluid-derived mesenchymal cells have non-inferior chondrogenic potential and can be utilized for regenerative therapy as substitute for synovium-derived cells. Biochem. Biophys. Res. Commun.. 2020.03; 523 (2): 465-472. ( PubMed, DOI )

Nobutake Ozeki, Hideyuki Koga, Junpei Matsuda, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Tomoyuki Saito, Takeshi Muneta, Ichiro Sekiya. Biomechanical analysis of the centralization procedure for extruded lateral menisci with posterior root deficiency in a porcine model. J Orthop Sci. 2020.01; 25 (1): 161-166. ( PubMed, DOI )

Naoto Watanabe, Mitsuru Mizuno, Junpei Matsuda, Naoko Nakamura, Koji Otabe, Hisako Katano, Nobutake Ozeki, Yuji Kohno, Tsuyoshi Kimura, Kunikazu Tsuji, Hideyuki Koga, Akio Kishida, Ichiro Sekiya. Comparison of High-Hydrostatic-Pressure Decellularized Versus Freeze-Thawed Porcine Menisci. J. Orthop. Res.. 2019.11; 37 (11): 2466-2475.

Shimpei Kondo, Yusuke Nakagawa, Mitsuru Mizuno, Kenta Katagiri, Kunikazu Tsuji, Shinji Kiuchi, Hideo Ono, Takeshi Muneta, Hideyuki Koga, Ichiro Sekiya. Transplantation of Aggregates of Autologous Synovial Mesenchymal Stem Cells for Treatment of Cartilage Defects in the Femoral Condyle and the Femoral Groove in Microminipigs. Am J Sports Med. 2019.08; 47 (10): 2338-2347. ( PubMed, DOI )

Ryota Fujisawa, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Cryopreservation in 95% serum with 5% DMSO maintains colony formation and chondrogenic abilities in human synovial mesenchymal stem cells. BMC Musculoskelet Disord. 2019.07; 20 (1): 316. ( PubMed, DOI )

Kaori Nakamura, Kunikazu Tsuji, Mitsuru Mizuno, Hideyuki Koga, Takeshi Muneta, Ichiro Sekiya. Initial cell plating density affects properties of human primary synovial mesenchymal stem cells. J. Orthop. Res.. 2019.06; 37 (6): 1358-1367. ( PubMed, DOI )

Inomata Kei, Tsuji Kunilazu, Onuma Hroaki, Hoshino Takashi, Udo Mio, Akiyama Masako, Nakagawa Yusuke, Katagiri Hiroki, Miyatake Kazumasa, Sekiya Ichiro, Muneta Takeshi, Koga Hideyuki. Time course analyses of structural changes in the infrapatellar fat pad and synovial membrane during inflammation-induced persistent pain development in rat knee joint BMC Musculoskelet Disord. 2019.01; 20 (8):

Takashi Hoshino, Kunikazu Tsuji, Hiroaki Onuma, Mio Udo, Hiroko Ueki, Masako Akiyama, Kahaer Abula, Hiroki Katagiri, Kazumasa Miyatake, Toshihumi Watanabe , Ichiro Sekiya, Hideyuki Koga, Takeshi Muneta. Persistent synovial inflammation plays important roles in persistent pain development in the rat knee before cartilage degradation reaches the subchondral bone BMC Musculoskeletal Disorders. 2018.08; 19 (1): 291.

Akari Sasaki, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Koji Otabe, Kunikazu Tsuji, Hideyuki Koga, Manabu Mochizuki, Ichiro Sekiya. Canine mesenchymal stem cells from synovium have a higher chondrogenic potential than those from infrapatellar fat pad, adipose tissue, and bone marrow. PLoS ONE. 2018.08; 13 (8): e0202922. ( PubMed, DOI )

Shoichi Hasegawa, Masafumi Horie, Hiroki Katagiri, Kunikazu Tsuji, Takeshi Muneta, Hideyuki Koga. Bilateral Hypoplasia of Both Medial and Lateral Menisci Partially Fused With the Cartilage Surface of the Tibial Plateau Orthopedics. 2018.08; 2018 (17): 1-4.

Mari Uomizu, Takeshi Muneta, Miyoko Ojima, Ichiro Sekiya, Hideyuki Koga, Kunikazu Tsuji. PDGF-induced proliferation and differentiation of synovial mesenchymal stem cells is mediated by the PI3K-PKB/Akt pathway. J Med Dent Sci. 2018.06; 65 (2): 73-82.

Mana Naritomi, Mitsuru Mizuno, Hisako Katano, Nobutake Ozeki, Koji Otabe, Keiichiro Komori, Shizuka Fujii, Shizuko Ichinose, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta, Ichiro Sekiya. Petaloid recombinant peptide enhances in vitro cartilage formation by synovial mesenchymal stem cells. J. Orthop. Res.. 2018.06; 37 (6): 1350-1357. ( PubMed, DOI )

Mitsuru Mizuno, Hisako Katano, Yo Mabuchi, Yusuke Ogata, Shizuko Ichinose, Shizuka Fujii, Koji Otabe, Keiichiro Komori, Nobutake Ozeki, Hideyuki Koga, Kunikazu Tsuji, Chihiro Akazawa, Takeshi Muneta, Ichiro Sekiya. Specific markers and properties of synovial mesenchymal stem cells in the surface, stromal, and perivascular regions. Stem Cell Res Ther. 2018.05; 9 (1): 123. ( PubMed, DOI )

Guangwen Jin, Alkebaier Aobulikasimu, Jinying Piao, Zulipiya Aibibula, Daisuke Koga, Shingo Sato, Hiroki Ochi, Kunikazu Tsuji, Tetsuo Nakabayashi, Toshio Miyata, Atsushi Okawa, Yoshinori Aso. A small-molecule PAI-1 inhibitor prevents bone loss by stimulating bone formation in a murine estrogen deficiency-induced osteoporosis model FEBS Open Bio. 2018.02; 8 (4): 523-532.

Takuya Oyaizu, Mitsuhiro Enomoto, Naoki Yamamoto, Kunikazu Tsuji, Masaki Horie, Takeshi Muneta, Ichiro Sekiya, Atsushi Okawa, Kazuyoshi Yagishita. Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation. Sci Rep. 2018.01; 8 (1): 1288. ( PubMed, DOI )

Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yuji Kohno, Shizuka Fujii, Nobutake Ozeki, Masafumi Horie, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta, Ichiro Sekiya. Complete human serum maintains viability and chondrogenic potential of human synovial stem cells: suitable conditions for transplantation. Stem Cell Res Ther. 2017.06; 8 (1): 144. ( PubMed, DOI )

Kunikazu Tsuji, Miyoko Ojima, Koji Otabe, Masafumi Horie, Hideyuki Koga, Ichiro Sekiya, Takeshi Muneta. Effects of Different Cell-Detaching Methods on the Viability and Cell Surface Antigen Expression of Synovial Mesenchymal Stem Cells. Cell Transplant. 2017.06; 26 (6): 1089-1102. ( PubMed, DOI )

Shimpei Kondo, Takeshi Muneta, Yusuke Nakagawa, Hideyuki Koga, Toshifumi Watanabe, Kunikazu Tsuji, Shinichi Sotome, Atsushi Okawa, Shinji Kiuchi, Hideo Ono, Mitsuru Mizuno, Ichiro Sekiya. Transplantation of autologous synovial mesenchymal stem cells promotes meniscus regeneration in aged primates. J. Orthop. Res.. 2017.06; 35 (6): 1274-1282. ( PubMed, DOI )

Mikio Shioda, Takeshi Muneta, Kunikazu Tsuji, Mitsuru Mizuno, Keiichiro Komori, Hideyuki Koga, Ichiro Sekiya. TNFα promotes proliferation of human synovial MSCs while maintaining chondrogenic potential. PLoS ONE. 2017.05; 12 (5): e0177771. ( PubMed, DOI )

Nobutake Ozeki, Takeshi Muneta, Kenichi Kawabata, Hideyuki Koga, Yusuke Nakagawa, Ryusuke Saito, Mio Udo, Katsuaki Yanagisawa, Toshiyuki Ohara, Tomoyuki Mochizuki, Kunikazu Tsuji, Tomoyuki Saito, Ichiro Sekiya. Centralization of extruded medial meniscus delays cartilage degeneration in rats. J Orthop Sci. 2017.05; 22 (3): 542-548. ( PubMed, DOI )

Etsuko Matsumura, Kunikazu Tsuji, Keiichiro Komori, Hideyuki Koga, Ichiro Sekiya, Takeshi Muneta. Pretreatment with IL-1β enhances proliferation and chondrogenic potential of synovium-derived mesenchymal stem cells. Cytotherapy. 2017.02; 19 (2): 181-193. ( PubMed, DOI )

Ryusuke Saito, Takeshi Muneta, Nobutake Ozeki, Yusuke Nakagawa, Mio Udo, Katsuaki Yanagisawa, Kunikazu Tsuji, Makoto Tomita, Hideyuki Koga, Ichiro Sekiya. Strenuous running exacerbates knee cartilage erosion induced by low amount of mono-iodoacetate in rats. BMC Musculoskelet Disord. 2017.01; 18 (1): 36. ( PubMed, DOI )

Makiko Inoue, Takeshi Muneta, Miyoko Ojima, Kaori Nakamura, Hideyuki Koga, Ichiro Sekiya, Mutsumi Okazaki, Kunikazu Tsuji. Inflammatory cytokine levels in synovial fluid 3, 4 days postoperatively and its correlation with early-phase functional recovery after anterior cruciate ligament reconstruction: a cohort study. J Exp Orthop. 2016.12; 3 (1): 30. ( PubMed, DOI )

Katsuaki Yanagisawa, Takeshi Muneta, Nobutake Ozeki, Yusuke Nakagawa, Mio Udo, Ryusuke Saito, Hideyuki Koga, Kunikazu Tsuji, Ichiro Sekiya. Weekly injections of Hylan G-F 20 delay cartilage degeneration in partial meniscectomized rat knees BMC Musculoskelet Disord. . 2016.12; 2016 (17): 188.

Kanehiro Hiyama, Takeshi Muneta, Hideyuki Koga, Ichiro Sekiya, Kunikazu Tsuji. Meniscal regeneration after resection of the anterior half of the medial meniscus in mice. J. Orthop. Res.. 2016.11; ( PubMed, DOI )

Udo M, Muneta T, Tsuji K, Ozeki N, Nakagawa Y, Ohara T, Saito R, Yanagisawa K, Koga H, Sekiya I. Monoiodoacetic acid induces arthritis and synovitis in rats in a dose- and time-dependent manner: proposed model-specific scoring systems Osteoarthritis Cartilage. 2016.07; 24 (7): 1284-1291.

Kazumasa Miyatake, Takeshi Muneta, Miyoko Ojima, Jun Yamada, Yu Matsukura, Kahaer Abula, Ichiro Sekiya, Kunikazu Tsuji. Coordinate and synergistic effects of extensive treadmill exercise and ovariectomy on articular cartilage degeneration BMC Musculoskelet Disord. 2016.05; 17 (1): 238.

Yusuke Nakagawa, Ichiro Sekiya, Shimpei Kondo, Takashi Tabuchi, Shizuko Ichinose, Hideyuki Koga, Kunikazu Tsuji, Takeshi Muneta. Relationship between MRI T1 rho value and histological findings of intact and radially incised menisci in microminipigs. J Magn Reson Imaging. 2016.02; 43 (2): 434-445. ( PubMed, DOI )

Yusuke Nakagawa, Takeshi Muneta, Koji Otabe, Nobutake Ozeki, Mitsuru Mizuno, Mio Udo, Ryusuke Saito, Katsuaki Yanagisawa, Shizuko Ichinose, Hideyuki Koga, Kunikazu Tsuji, Ichiro Sekiya. Cartilage Derived from Bone Marrow Mesenchymal Stem Cells Expresses Lubricin In Vitro and In Vivo PLoS One. 2016 Feb 11;11(2):e0148777.. 2016.02; 11 (2):

Ozeki N,Muneta T, Koga H, Nakagawa Y, Mizuno M, Tsuji K, Mabuchi Y, Akazawa C, Kobayashi E, Matsumoto K, Futamura K, Saito T, Sekiya I.. Not single but periodic injections of synovial mesenchymal stem cells maintain viable cells in knees and inhibit osteoarthritis progression in rats Osteoarthritis and Cartilage. 2016;

Ohara T, Muneta T, Nakagawa Y, Matsukura Y, Ichinose S, Koga H, Tsuji K, Sekiya I. Hypoxia enhances proliferation through increase of colony formation rate with chondrogenic potential in primary synovial mesenchymal stem cells J Med Dent Sci. . 2016; 63 (4): 61-70.

Nobutake Ozeki, Takeshi Muneta, Seiya Matsuta, Hideyuki Koga, Yusuke Nakagawa, Mitsuru Mizuno, Kunikazu Tsuji, Yo Mabuchi, Chihiro Akazawa, Eiji Kobayashi, Tomoyuki Saito, Ichiro Sekiya. Synovial mesenchymal stem cells promote meniscus regeneration augmented by an autologous Achilles tendon graft in a rat partial meniscus defect mode Stem Cells. 2015.06; 33 (6): 1927-1938.

Y Nakagawa, T Muneta, S Kondo, M Mizuno, K Takakuda, S Ichinose, T Tabuchi, H Koga, K Tsuji, I Sekiya. Synovial mesenchymal stem cells promote healing after meniscal repair in microminipigs Osteoarthr. Cartil.. 2015.06; 23 (6): 1007-1017.

Abula Kahaer、MunetaTakeshi、Miyatake Kazumasa、Yamada Jun、Matsukra Yu、InInoue Makiko、Sekiya Ichiro、Graf Daniel、Economides Aris N、Rosen Vicki、Tsuji Kunikazu. Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age FEBS Lett. 2015.05; 589 (11): 1240-1248.

Yu Matsukura, Takeshi Muneta, Kunikazu Tsuji, Kazumasa Miyatake, Jun Yamada, Kahaer Abula, Hideyuki Koga, Makoto Tomita, Ichiro Sekiya. Mouse synovial mesenchymal stem cells increase in yield with knee inflammatio J Orthop Res. 2015.02; 33 (2): 246-253.

Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yukie Matsumoto, Shizuka Fujii, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta, Akifumi Matsuyama, Ichiro Sekiya. Platelet-derived growth factor (PDGF)-AA/AB in human serum are potential indicators of the proliferative capacity of human synovial mesenchymal stem cells Stem Cell Res Ther. . 2015; 2015 (6): 243.

Hatsushika D, Muneta T, Nakamura T, Horie M, Koga H, Nakagawa Y, Tsuji K, Hishikawa S, Kobayashi E, Sekiya I. Repetitive allogeneic intraarticular injections of synovial mesenchymal stem cells promote meniscus regeneration in a porcine massive meniscus defect model. Osteoarthritis Cartilage. 2014.07; 22 (7): 941-950. ( PubMed, DOI )

Okuno Makiko, Muneta Takeshi, Koga Hideyuki, Ozeki Nobutake, Nakagawa Yusuke, Tsuji Kunikazu, Yoshiya Shinichi, Sekiya Ichiro. Meniscus regeneration by syngeneic, minor mismatched, and major mismatched transplantation of synovial mesenchymal stem cells in a rat model. J Orthop Res. 2014.07; 32 (7): 928-936. ( PubMed, DOI )

Suzuki Nobuharu, Mizuniwa Chihiro, Ishii Kana, Nakagawa Yusuke, Tsuji Kunikazu, Muneta Takeshi, Sekiya Ichiro, Akazawa Chihiro. Teneurin-4, a transmembrane protein, is a novel regulator that suppresses chondrogenic differentiation J Orthop Res. . 2014.07; 32 (7): 915-922.

Matsukura Yu, Muneta Takeshi, Tsuji Kunikazu, Koga Hideyuki, Sekiya Ichiro. Mesenchymal stem cells in synovial fluid increase after meniscus injury. Clin Orthop Relat Res. 2014.05; 472 (5): 1357-1364. ( PubMed, DOI )

Yamada Jun, Tsuji Kunikazu, Miyatake Kazumasa, Matsukura Yu, Abula Kahaer, Inoue Makiko, Sekiya Ichiro, Muneta Takeshi. Follistatin alleviates synovitis and articular cartilage degeneration induced by carrageenan. Int J Inflam. 2014; 2014 959271. ( PubMed, DOI )

Ozeki Nobutake, Muneta Takeshi, Koga Hideyuki, Katagiri Hiroki, Otabe Koji, Okuno Makiko, Tsuji Kunikazu, Kobayashi Eiji, Matsumoto Kenji, Saito Hirohisa, Saito Tomoyuki, Sekiya Ichiro. Transplantation of Achilles tendon treated with bone morphogenetic protein 7 promotes meniscus regeneration in a rat model of massive meniscal defect. Arthritis Rheum. 2013.11; 65 (11): 2876-2886. ( PubMed, DOI )

Piao J1, Tsuji K, Ochi H, Iwata M, Koga D, Okawa A, Morita S, Takeda S, Asou Y. Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling Sci Rep. 2013 Oct 23;3:3022. 2013.10; (3): 3022.

Hatsushika Daisuke, Muneta Takeshi, Horie Masafumi, Koga Hideyuki, Tsuji Kunikazu, Sekiya Ichiro. Intraarticular injection of synovial stem cells promotes meniscal regeneration in a rabbit massive meniscal defect model. J Orthop Res. 2013.09; 31 (9): 1354-1359. ( PubMed, DOI )

Hiroki Katagiri, Takeshi Muneta, Kunikazu Tsuji, Masafumi Horie, Hideyuki Koga, Nobutake Ozeki, Eiji Kobayashi, Ichiro Sekiya. Transplantation of aggregates of synovial mesenchymal stem cells regenerates meniscus more effectively in a rat massive meniscal defect. Biochem. Biophys. Res. Commun.. 2013.06; 435 (4): 603-609. ( PubMed, DOI )

Kazumasa Miyatake, Kunikazu Tsuji, Mika Yamaga, Jun Yamada, Yu Matsukura, Kahaer Abula, Ichiro Sekiya, Takeshi Muneta. Human YKL39 (chitinase 3-like protein 2), an osteoarthritis-associated gene, enhances proliferation and type II collagen expression in ATDC5 cells. Biochem. Biophys. Res. Commun.. 2013.02; 431 (1): 52-57. ( PubMed, DOI )

Mika Yamaga, Kunikazu Tsuji , Kazumasa Miyatake, Jun Yamada, Kahaer Abula, Young-Jin Ju, Ichiro Sekiya, Takeshi Muneta. Osteopontin Level in Synovial Fluid Is Associated with the Severity of Joint Pain and Cartilage Degradation after Anterior Cruciate Ligament Rupture PLoS One. 2012.11; 7 (11): e49014.

Koji Otabe, Takeshi Muneta, Nobuyuki Kawashima, Hideaki Suda, Kunikazu Tsuji, Ichiro Sekiya. Comparison of Gingiva, Dental Pulp, and Periodontal Ligament Cells From the Standpoint of Mesenchymal Stem Cell Properties Cell Med.. 2012.08; 4 (1): 13-21.

Ichiro Sekiya, Miyoko Ojima, Shiro Suzuki, Mika Yamaga, Masafumi Horie, Hideyuki Koga, Kunikazu Tsuji, Ken Miyaguchi, Soichi Ogishima, Hiroshi Tanaka, Takeshi Muneta. Human mesenchymal stem cells in synovial fluid increase in the knee with degenerated cartilage and osteoarthritis. J. Orthop. Res.. 2012.06; 30 (6): 943-949. ( PubMed, DOI )

Shiro Suzuki, Takeshi Muneta, Kunikazu Tsuji, Shizuko Ichinose, Hatsune Makino, Akihiro Umezawa,Ichiro Sekiya. Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration Arthritis Res Ther. . 2012.06; 14 (3): R136.

Shoichiro Kokabu, Laura Gamer, Karen Cox, Jonathan Lowery, Kunikazu Tsuji, Regina Raz, Aris Economides, Takenobu Katagiri, Vicki Rosen. BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b. Mol. Endocrinol.. 2012.01; 26 (1): 87-94. ( PubMed, DOI )

Nakamura T, Sekiya I, Muneta T, Hatsushika D, Horie M, Tsuji K, Kawarasaki T, Watanabe A, Hishikawa S, Fujimoto Y, Tanaka H, Kobayashi E. Arthroscopic, histological, and MRI analyses of cartilage repair after a minimally invasive method of transplantation of allogeneic synovial mesenchymal stem cells into cartilage defects in pigs Cytotherapy. 2012;

Ippei Futami, Muneaki Ishijima, Haruka Kaneko, Kunikazu Tsuji, Naoki Ichikawa-Tomikawa, Ryo Sadatsuki, Takeshi Muneta, Eri Arikawa-Hirasawa, Ichiro Sekiya, Kazuo Kaneko. Isolation and characterization of multipotential mesenchymal cells from the mouse synovium PLoS One. 2012; 7 (9): e45517.

Laura W Gamer, Kunikazu Tsuji, Karen Cox, Luciane P Capelo, Jonathan Lowery, Hideyuki Beppu, Vicki Rosen. BMPR-II is dispensable for formation of the limb skeleton. Genesis. 2011.09; 49 (9): 719-724. ( PubMed, DOI )

Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga, Akimoto Nimura, Toshiyuki Morito, Masayuki Shimaya, Tomoyuki Mochizuki, Yuko Segawa, Yusuke Sakaguchi, Kunikazu Tsuji, Shizuko Ichinose. [Articular cartilage regeneration with synovial mesenchymal stem cells]. Clin Calcium. 2011.06; 21 (6): 879-889. ( PubMed, DOI )

Toru TakahashiTakeshi MunetaKunikazu TsujiIchiro Sekiya. BMP-7 inhibits cartilage degeneration through suppression of inflammation in rat zymosan-induced arthritis Cell Tissue Res. . 2011.05; 344 (2): 321-322.

Masaya Hayashi, Takeshi Muneta, Toru Takahashi, Young-Jin Ju, Kunikazu Tsuji, Ichiro Sekiya. Intra-articular injections of bone morphogenetic protein-7 retard progression of existing cartilage degeneration. J. Orthop. Res.. 2010.11; 28 (11): 1502-1506. ( PubMed, DOI )

Konstantina M. Stankovic, Osamu Adachi, Kunikazu Tsuji, Arthur G. Kristiansen, Joe C. Adams, Vicki Rosen, Michael J. McKenna. Differences in gene expression between the otic capsule and other bones Hear Res. . 2010.06; 265 (1-2): 83-89.

Sadanori Shimizu, Naoki Okuda, Norihiko Kato, Susan R. Rittling, Atsushi Okawa, Kenichi Shinomiya, Takeshi Muneta, David T. Denhardt, Masaki Noda, Kunikazu Tsuji, Yoshinori Asou. Osteopontin deficiency impairs wear debris-induced osteolysis via regulation of cytokine secretion from murine macrophages Arthritis Rheum. 2010.05; 62 (5): 1329-1337.

Kunikazu Tsuji, Karen Cox, Laura Gamer, Daniel Graf, Aris Economides, Vicki Rosen. Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair J Orthop Res. . 2010.03; 28 (3): 384-389.

Ichiro Sekiya, Toshiyuki Morito, Kenji Hara, Junya Yamazaki, Young-Jin Ju, Kazuyoshi Yagishita, Tomoyuki Mochizuki, Kunikazu Tsuji, Takeshi Muneta. Ketoprofen absorption by muscle and tendon after topical or oral administration in patients undergoing anterior cruciate ligament reconstruction. AAPS PharmSciTech. 2010.03; 11 (1): 154-158. ( PubMed, DOI )

Shizuko Ichinose, Takeshi Muneta, Hideyuki Koga, Yuko Segawa, Motoki Tagami, Kunikazu Tsuji, Ichiro Sekiya. Morphological differences during in vitro chondrogenesis of bone marrow-, synovium-MSCs, and chondrocytes. Lab. Invest.. 2010.02; 90 (2): 210-221. ( PubMed, DOI )

Takashi Miyamoto, Takeshi Muneta, Takashi Tabuchi, Kenji Matsumoto, Hirohisa Saito, Kunikazu Tsuji, Ichiro Sekiya. Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits. Arthritis Res. Ther.. 2010; 12 (6): R206. ( PubMed, DOI )

Kunikazu Tsuji, Karen Cox, Amitabha Bandyopadhyay, Brian D Harfe, Clifford J Tabin, Vicki Rosen. BMP4 is dispensable for skeletogenesis and fracture-healing in the limb. J Bone Joint Surg Am. 2008.02; 90 Suppl 1 14-18. ( PubMed, DOI )

Muneaki Ishijima, Kunikazu Tsuji, Susan R Rittling, Teruhito Yamashita, Hisashi Kurosawa, David T Denhardt, Akira Nifuji, Yoichi Ezura, Masaki Noda. Osteopontin is required for mechanical stress-dependent signals to bone marrow cells. J. Endocrinol.. 2007.05; 193 (2): 235-243. ( PubMed, DOI )

Amitabha Bandyopadhyay, Kunikazu Tsuji, Karen Cox, Brian D Harfe, Vicki Rosen, Clifford J Tabin. Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet.. 2006.12; 2 (12): e216. ( PubMed, DOI )

Kunikazu Tsuji, Amitabha Bandyopadhyay, Brian D Harfe, Karen Cox, Sanjeev Kakar, Louis Gerstenfeld, Thomas Einhorn, Clifford J Tabin, Vicki Rosen. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat. Genet.. 2006.12; 38 (12): 1424-1429. ( PubMed, DOI )

Muneaki Ishijima, Yoichi Ezura, Kunikazu Tsuji, Susan R Rittling, Hisashi Kurosawa, David T Denhardt, Mitsuru Emi, Akira Nifuji, Masaki Noda. Osteopontin is associated with nuclear factor kappaB gene expression during tail-suspension-induced bone loss. Exp. Cell Res.. 2006.10; 312 (16): 3075-3083. ( PubMed, DOI )

K Hino, A Nifuji, M Morinobu, K Tsuji, Y Ezura, K Nakashima, H Yamamoto, M Noda. Unloading-induced bone loss was suppressed in gold-thioglucose treated mice. J. Cell. Biochem.. 2006.10; 99 (3): 845-852. ( PubMed, DOI )

Yuki Koyama, Susan R Rittling, Kunikazu Tsuji, Kazunori Hino, Ruchanee Salincarnboriboon, Tetsu Yano, Yuji Taketani, Akira Nifuji, David T Denhardt, Masaki Noda. Osteopontin deficiency suppresses high phosphate load-induced bone loss via specific modulation of osteoclasts. Endocrinology. 2006.06; 147 (6): 3040-3049. ( PubMed, DOI )

Ruchanee Salingcarnboriboon, Kunikazu Tsuji, Toshihisa Komori, Kazuhisa Nakashima, Yoichi Ezura, Masaki Noda. Runx2 is a target of mechanical unloading to alter osteoblastic activity and bone formation in vivo. Endocrinology. 2006.05; 147 (5): 2296-2305. ( PubMed, DOI )

Mikihiko Morinobu, Tetsuya Nakamoto, Kazunori Hino, Kunikazu Tsuji, Zhong-Jian Shen, Kazuhisa Nakashima, Akira Nifuji, Haruyasu Yamamoto, Hisamaru Hirai, Masaki Noda. The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein-induced bone formation. J. Exp. Med.. 2005.03; 201 (6): 961-970. ( PubMed, DOI )

Yoshio Ohyama, Hiroyuki Nemoto, Susan Rittling, Kunikazu Tsuji, Teruo Amagasa, David T Denhardt, Akira Nifuji, Masaki Noda. Osteopontin-deficiency suppresses growth of B16 melanoma cells implanted in bone and osteoclastogenesis in co-cultures. J. Bone Miner. Res.. 2004.10; 19 (10): 1706-1711. ( PubMed, DOI )

Yukiko Maeda, Kunikazu Tsuji, Akira Nifuji, Masaki Noda. Inhibitory helix-loop-helix transcription factors Id1/Id3 promote bone formation in vivo. J. Cell. Biochem.. 2004.10; 93 (2): 337-344. ( PubMed, DOI )

Kunikazu Tsuji, Toshihisa Komori, Masaki Noda. Aged mice require full transcription factor, Runx2/Cbfa1, gene dosage for cancellous bone regeneration after bone marrow ablation. J. Bone Miner. Res.. 2004.09; 19 (9): 1481-1489. ( PubMed, DOI )

Michihiko Usui, Yutaka Yoshida, Kunikazu Tsuji, Kaoru Oikawa, Kohei Miyazono, Isao Ishikawa, Tadashi Yamamoto, Akira Nifuji, Masaki Noda. Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis. Proc. Natl. Acad. Sci. U.S.A.. 2004.04; 101 (17): 6653-6658. ( PubMed, DOI )

Choo-ryung J Chung, Kunikazu Tsuji, Akira Nifuji, Toshihisa Komori, Kunimichi Soma, Masaki Noda. Micro-CT evaluation of tooth, calvaria and mechanical stress-induced tooth movement in adult Runx2/Cbfa1 heterozygous knock-out mice. J. Med. Dent. Sci.. 2004.03; 51 (1): 105-113. ( PubMed )

Mikihiko Morinobu, Muneaki Ishijima, Susan R Rittling, Kunikazu Tsuji, Haruyasu Yamamoto, Akira Nifuji, David T Denhardt, Masaki Noda. Osteopontin expression in osteoblasts and osteocytes during bone formation under mechanical stress in the calvarial suture in vivo. J. Bone Miner. Res.. 2003.09; 18 (9): 1706-1715. ( PubMed, DOI )

R Salingcarnboriboon, H Yoshitake, K Tsuji, M Obinata, T Amagasa, A Nifuji, M Noda. Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like property. Exp. Cell Res.. 2003.07; 287 (2): 289-300. ( PubMed )

M Takamoto, K Tsuji, T Yamashita, H Sasaki, T Yano, Y Taketani, T Komori, A Nifuji, M Noda. Hedgehog signaling enhances core-binding factor a1 and receptor activator of nuclear factor-kappaB ligand (RANKL) gene expression in chondrocytes. J. Endocrinol.. 2003.06; 177 (3): 413-421. ( PubMed )

Keiichiro Kitahara, Muneaki Ishijima, Susan R Rittling, Kunikazu Tsuji, Hisashi Kurosawa, Akira Nifuji, David T Denhardt, Masaki Noda. Osteopontin deficiency induces parathyroid hormone enhancement of cortical bone formation. Endocrinology. 2003.05; 144 (5): 2132-2140. ( PubMed, DOI )

Masaki Noda, Kunikazu Tsuji, Akira Nifuji. [Osteopontin: a topic from the point of bone morphology]. Clin Calcium. 2003.04; 13 (4): 464-466. ( PubMed, DOI )

K Yagi, K Tsuji, A Nifuji, K Shinomiya, K Nakashima, B DeCrombrugghe, Masaki Noda. Bone morphogenetic protein-2 enhances osterix gene expression in chondrocytes. J. Cell. Biochem.. 2003.04; 88 (6): 1077-1083. ( PubMed, DOI )

K Kashimada, T Yamashita, K Tsuji, A Nifuji, S Mizutani, Y Nabeshima, M Noda. Defects in growth and bone metabolism in klotho mutant mice are resistant to GH treatment. J. Endocrinol.. 2002.09; 174 (3): 403-410. ( PubMed )

Zhong-Jian Shen, Tetsuya Nakamoto, Kunikazu Tsuji, Akira Nifuji, Kohei Miyazono, Toshihisa Komori, Hisamaru Hirai, Masaki Noda. Negative regulation of bone morphogenetic protein/Smad signaling by Cas-interacting zinc finger protein in osteoblasts. J. Biol. Chem.. 2002.08; 277 (33): 29840-29846. ( PubMed, DOI )

Yoshinori Asou, Akira Nifuji, Kunikazu Tsuji, Kenichi Shinomiya, Eric N Olson, Peter Koopman, Masaki Noda. Coordinated expression of scleraxis and Sox9 genes during embryonic development of tendons and cartilage. J. Orthop. Res.. 2002.07; 20 (4): 827-833. ( PubMed, DOI )

Michihiko Usui, Yutaka Yoshida, Teruhito Yamashita, Kunikazu Tsuji, Ishikawa Isao, Tadashi Yamamoto, Akira Nifuji, Masaki Noda. Enhancing effect of Tob deficiency on bone formation is specific to bone morphogenetic protein-induced osteogenesis. J. Bone Miner. Res.. 2002.06; 17 (6): 1026-1033. ( PubMed, DOI )

Kenji Yumoto, Muneaki Ishijima, Susan R Rittling, Kunikazu Tsuji, Yoko Tsuchiya, Shigeyuki Kon, Akira Nifuji, Toshimitsu Uede, David T Denhardt, Masaki Noda. Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice. Proc. Natl. Acad. Sci. U.S.A.. 2002.04; 99 (7): 4556-4561. ( PubMed, DOI )

Muneaki Ishijima, Kunikazu Tsuji, Susan R Rittling, Teruhito Yamashita, Hisashi Kurosawa, David T Denhardt, Akira Nifuji, Masaki Noda. Resistance to unloading-induced three-dimensional bone loss in osteopontin-deficient mice. J. Bone Miner. Res.. 2002.04; 17 (4): 661-667. ( PubMed, DOI )

Masaki Noda, Kunikazu Tsuji, Mikihiko Morinobu, Muneaki Ishijima, Akira Nifuji. [A gene involved in angiogenesis and bone -osteopontin] Clin Calcium. 2002.03; 12 (3): 363-367. ( PubMed, DOI )

Noda M., Ishijima M., Takamoto M., Tsuji K., Nifuji A.. [Bone regeneration and Mesenchymal stem cells] Clin Calcium . 2002; 12 187-192.

Noda M., Tsuji K., Ishijima M., Usui M., Takamoto M., Kashimada K., Nitou A. [Bone remodeling] Nihon Rinsho . 2002; 60 (3): 34-39.

I Sekiya, P Koopman, K Tsuji, S Mertin, V Harley, Y Yamada, K Shinomiya, A Nifuji, M Noda. Dexamethasone enhances SOX9 expression in chondrocytes. J. Endocrinol.. 2001.06; 169 (3): 573-579. ( PubMed )

K Tsuji, N Kraut, M Groudine, M Noda. Vitamin D(3) enhances the expression of I-mfa, an inhibitor of the MyoD family, in osteoblasts. Biochim. Biophys. Acta. 2001.05; 1539 (1-2): 122-130. ( PubMed )

H Nemoto, S R Rittling, H Yoshitake, K Furuya, T Amagasa, K Tsuji, A Nifuji, D T Denhardt, M Noda. Osteopontin deficiency reduces experimental tumor cell metastasis to bone and soft tissues. J. Bone Miner. Res.. 2001.04; 16 (4): 652-659. ( PubMed, DOI )

H Ihara, D T Denhardt, K Furuya, T Yamashita, Y Muguruma, K Tsuji, K A Hruska, K Higashio, S Enomoto, A Nifuji, S R Rittling, M Noda. Parathyroid hormone-induced bone resorption does not occur in the absence of osteopontin. J. Biol. Chem.. 2001.04; 276 (16): 13065-13071. ( PubMed, DOI )

Y Asou, S R Rittling, H Yoshitake, K Tsuji, K Shinomiya, A Nifuji, D T Denhardt, M Noda. Osteopontin facilitates angiogenesis, accumulation of osteoclasts, and resorption in ectopic bone. Endocrinology. 2001.03; 142 (3): 1325-1332. ( PubMed, DOI )

M Ishijima, S R Rittling, T Yamashita, K Tsuji, H Kurosawa, A Nifuji, D T Denhardt, M Noda. Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin. J. Exp. Med.. 2001.02; 193 (3): 399-404. ( PubMed )

K Tsuji, M Noda. Transient suppression of core-binding factor alpha 1 expression by basic fibroblast growth factor in rat osteoblast-like osteosarcoma ROS17/2.8 cells. J. Bone Miner. Metab.. 2001; 19 (4): 213-219. ( PubMed )

I Sekiya, P Koopman, K Tsuji, S Mertin, V Harley, Y Yamada, K Shinomiya, A Niguji, M Noda. Transcriptional suppression of Sox9 expression in chondrocytes by retinoic acid. J. Cell. Biochem. Suppl.. 2001; Suppl 36 71-78. ( PubMed )

K Furuya, T Nakamoto, Z J Shen, K Tsuji, A Nifuji, H Hirai, M Noda. Overexpression of Cas-interacting zinc finger protein (CIZ) suppresses proliferation and enhances expression of type I collagen gene in osteoblast-like MC3T3E1 cells. Exp. Cell Res.. 2000.12; 261 (2): 329-335. ( PubMed, DOI )

野田 政樹(東京医科歯科大学難治疾患研究所), 村上 俊一, 辻 邦和, 二藤 彰. 最新学際情報　hedgehogと骨形成(解説) 関節外科 . 2000.07; 19 (7): 910-916. ( ichushi )

K Tsuji, M Noda. Identification and expression of a novel 3'-exon of mouse Runx1/Pebp2alphaB/Cbfa2/AML1 gene. Biochem. Biophys. Res. Commun.. 2000.07; 274 (1): 171-176. ( PubMed, DOI )

Y Takazawa, K Tsuji, A Nifuji, H Kurosawa, Y Ito, M Noda. An osteogenesis-related transcription factor, core-binding factor A1, is constitutively expressed in the chondrocytic cell line TC6, and its expression is upregulated by bone morphogenetic protein-2. J. Endocrinol.. 2000.06; 165 (3): 579-586. ( PubMed )

I Sekiya, K Tsuji, P Koopman, H Watanabe, Y Yamada, K Shinomiya, A Nifuji, M Noda. SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6. J. Biol. Chem.. 2000.04; 275 (15): 10738-10744. ( PubMed )

T Yamashita, H Yoshitake, K Tsuji, N Kawaguchi, Y Nabeshima, M Noda. Retardation in bone resorption after bone marrow ablation in klotho mutant mice. Endocrinology. 2000.01; 141 (1): 438-445. ( PubMed, DOI )

野田 政樹(東京医科歯科大学難治疾患研究所), 辻 邦和, 高澤 祐治, 古屋 高一, 関矢 一郎, 儀武 啓幸, 二藤 彰. 【再生医学】　臓器再生の基礎と臨床の接点　骨芽細胞の分化制御にかかわる分子群(解説/特集) 最新医学 . 1999.12; 54 (12): 2836-2842. ( ichushi )

Noda M, Tsuji K, Yamashita T, Kawaguchi N, Ezura Y, Li J, Murakami S, Sekiya I, Asou Y, Takazawa Y, Furuya K, Liu Y, Nifuji A. . Tissue Engineering in bone Tissue Engineering for Therapeutic Use. Excerpta Medica. International Congress Series. 1999; (1175): 153-158.

J Li, K Tsuji, T Komori, K Miyazono, J L Wrana, Y Ito, A Nifuji, M Noda. Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression in osteoblastic osteosarcoma ROS17/2.8 cells and primary rat calvaria cells. J. Biol. Chem.. 1998.11; 273 (47): 31009-31015. ( PubMed )

M Noda, A Nifuji, K Tuji, K Furuya, S Ichiro, Y Asou, N Kawaguchi, K Yamachita. Transcription factors and osteoblasts. Front. Biosci.. 1998.08; 3 d817-d820. ( PubMed )

K Tsuji, Y Ito, M Noda. Expression of the PEBP2alphaA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells. Bone. 1998.02; 22 (2): 87-92. ( PubMed )

K Tsuji, N G Copeland, N A Jenkins, M Obinata. Mammalian antioxidant protein complements alkylhydroperoxide reductase (ahpC) mutation in Escherichia coli. Biochem. J.. 1995.04; 307 ( Pt 2) 377-381. ( PubMed )

Miyoko Ojima, Kunikazu Tstuji, Koji Otabe, Masafumi Horie, Hideyuki Koga, Ichiro Sekiya, Takeshi Muneta. Different methods of detaching adherent cells significantly affect the detection of stem cell antigens in synovial mesenchymal stem cells.. OARSI 2016 World Congress on Osteoarthritis 2016.03.31

Toshiyuki Ohara,Takeshi Muneta, Yusuke Nakagawa, Yu Matsukura, Kunikazu Tsuji, Ichiro Sekiya. Hypoxia enhances proliferation with chondrogenic potential in primary synovial MSCs. Orthopaedic Research Society 2015 Annual Meeting 2016.03.05

Kaori Nakamrua, Kunikazu Tsuji, Hiroki Katagiri, Makiko Inoue, Miyoko Ojima, Ichiro Sekiya, Takeshi Muneta. Dynamic analysis of inflammatory cells in synovial fluid after index anterior cruciate ligament reconstruction surgery. Osteoarthritis Research Society 2016 Annual Meeting 2016.03.05

Etsuko Matsumura, Takeshi Muneta, Kunikazu Tsuji, Keiichiro Komori, Ichiro Sekiya. Il-1β Enhances Proliferation And Chondrogenic Potential Of Synovial MSCs. Orthopaedic Research Society 2016 Annual Meeting 2016.03.05 Orlando,USA

Nobutake Ozeki, Junpei Matsuda, Takeshi Muneta, Hideyuki Koga, Kunikazu Tsuji, Kenta Katagiri, Mitsuru Mizuno, T Saito, Ichiro Sekiya. Biomechanical analysis of centralization with an anchor for meniscus extrusion in a porcine model. ORS 2016 2016.03.05 Coroladsprings, USA

Yuji Kohno, Mitsuru Mizuno, Kenta Katagiri, Koji Otabe, Nobutake Ozeki, Masafumi Horie, Hideyuki Koga, Kunikazu Tsuji, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Takeshi Muneta, Ichiro Sekiya. Yields and chondrogenic potential of synovial MSCs are comparable between RA and OA patients who undergo TKA. Orthopaedic Research Society 2016 Annual Meeting 2016.03.05

Toshiyuki Ohara,Takeshi Muneta, Yu Matsukura, Kunikazu Tsuji, Ichiro Sekiya. Hypoxia enhances colony formation and proliferation with chondrogenic potential in passage 0 human synovial mesenchymal stem cells.. Orthopaedic Research Society 2015 Annual Meeting 2015.03.28

Ryusuke Saito, Ichiro Sekiya, Nobutake Ozeki, Yusuke Nakagawa, Mio Udo, Katsuaki Yanagisawa, Kunikazu Tsuji, Takeshi Muneta. Strenuous Running Enhances Degeneration Of Articular Cartilage In A Rat Mia-induced Arthritis Model. ORS 2015 Annual Meeting 2015.03.28 Las Vegas, USA

Mio Udo, Ichiro Sekiya, Kunikazu Tsuji, Nobutake Ozeki, Yusuke Nakagawa, Toshiyuki Ohara, Ryusuke Saito, Katsuaki Yanagisawa, Takeshi Muneta. Low Dosage Of Monoiodoacetic Acid Induces Arthritis Without Bone Defect In A Rat Model. ORS 2015 Annual Meeting 2015.03.28 Las Vegas, USA

Mio Udo, Ichiro Sekiya, Kunikazu Tsuji, Nobutake Ozeki, Yusuke Nakagawa, Toshiyuki Ohara, Ryusuke Saito, Katsuaki Yanagisawa, Takeshi Muneta. In Vivo Evaluation Of Arthritis By Mmp Activatable Probe In A Rat Mia-Induced Model. ORS 2015 Annual Meeting 2015.03.28 Las Vegas, USA

Miyatake Kazumasa,Tsuji Kunikazu,Yamada Jun,Matsukura Yu,Abula Kahaer,Arai Yoshinori,Sekiya Ichiro,Muneta Takeshi. Articular cartilage degeneration and synovitis observed in the ovariectomized mice are greatly exacerbated by forced running. 2013　ORS 2013.01.26 San Antonio

J Yamada,K Tsuji,K Miyatake,Y Matsukura,A Kahar,Y Arai,I Sekiya,T Muneta. Forced running (60km in 6wks) reverses bone and articular cartilage degeneration induced by ovariectomy in C57Bl/6 mice. 2013 ORS 2013.01.26 San Antonio

Kahaer Abula, Takeshi Muneta, Mika Yamaga, Kazumasa Miyatake, Jun Yamada, Yu Matsukura, Ichiro Sekiya, and Kunikazu Tsuji. Endogenous BMP7 activity is prerequisite for postnatal joint homeostasis . The 27th Annual Research Meeting of The Japanese Orthopedic Association 2012.10.27 Nagoya, Japan

Kahaer Abula, Takeshi Muneta,　Mika Yamaga, Kazumasa Miyatake, Jun Yamada, Yu Matsukura, Ichiro Sekiya, and Kunikazu Tsuji. Endogenous BMP7 activity is prerequisite for postnatal joint homeostasis. The American Society for Bone and Mineral Research’s 2012 Annual Meeting 2012.10.13 Minneapolis, US

Tsuji, K. Role of Endogenous BMP-7 in Articular Cartilage Homeostasis. International Conference on Bone Morphogenetic Proteins 2012.06.19 Granlibakken Conference Center, Lake Tahoe, CA, USA

辻　邦和. 硬組織のホメオスタシスにおける骨形成因子BMPの生理機能の解析. 第2回硬組織疾患ゲノムセンターセミナー 2012.05.30 東京医科歯科大学

Miyatake, Tsuji, Yamada, Kahaer, Matsukura, Sekiya, Muneta. Articular cartilage degradation induced by extensive treadmill exercise is greatly exacerbated by estrogen depletion in mice. 2013　OARSI 2012.04.26 Barcelona

Tsuji, K., Yamada, J., Miyatake, K., Abula, K., Matsukura, Y., Sekiya, I., and Muneta, T. Follistatin alleviates synovitis and articular cartilage degradation induced by carrageenan in mice. World Congress on Osteoarthritis, Barcelona’s International Convention Centre 2012.04.26 Barcelona, Spain

Suzuki S, Muneta T, Tsuji K, Sekiya I. Properties and usefulness of aggregates of synovial mesenchymal stem cells as a source for cartilage regeneration. Osteoarthritis Research Society International 2012.04.26 Barcelona, Spain

Kahaer Abula, Takeshi Muneta, Mika Yamaga, Kazumasa Miyatake, Jun Yamada, Yu Matsukura, Ichiro Sekiya, and Kunikazu Tsuji. BMP7 is prerequisite for postnatal joint homeostasis. The 25th Annual Meeting of The Japanese Society of Cartilage Metabolism 2012.03.09 Nagoya, Japan

Tsuji, K. Osteopontin level in synovial fluid is associated with the severity of joint pain and cartilage degradation after anterior cruciate ligament rupture. 久光製薬　海外特別招待講演会　〜ノルスパンテープ発売記念〜 2012.03.07 東京ガーデンパレス

Otabe, K; Sekiya, I; Kawashima, N; Tsuji K; Muneta, T. Properties of mesenchymal stem cells derived from removed teeth. 2012 Annual Meeting of the Orthopaedic Research Society 2012.02.04 San Francisco

Suzuki S, Muneta T, Tsuji K, Sekiya I. Properties and effectiveness of aggregated synovial mesenchymal stem cells for cartilage regeneration. Orthopaedic Research Society 2012.02.04 San Francisco, USA

Ozeki N, Sekiya I, Otabe K, Katagiri H, Okuno M, Tsuji K, Saito T, Muneta T. BMP-7 treated Achilles tendon transplantation for meniscal defect in a rat model. 2012 Annual Meeting of the Orthopaedic Research Society 2012.02.04 San Francisco, USA

J,Yamada. K,Miyatake. M,Yamaga.I,Sekiya. T,Muneta. K,Tsuji. Follistatin alleviates articular cartilage degradation induced by carrageenan. 2012　ORS 2012.02.04 San Francisco

Miyatake, K; Yamaga, M　Sekiya, I 　Muneta, T and Tsuji, K . Human chitinase 3-like protein 2 (YKL39) is a novel secreted protein which supports cell proliferation　and chondrocytic differentiation of ATDC5. 2012 ORS 2012.02.04 San Francisco

Daisuke Hatsushika,Ichiro Sekiya,Tomomasa Nakamura,Masafumi Horie,Hideyuki Koga,Kunikazu TsujiTakes,hi Muneta. Porcine massive meniscal defect is regenerated by intraarticular injections of synovial stem cells. ORS 2013Annual Meeting 2012.01.29 San Antonio

Kahaer Abula, Takeshi Muneta, Mika Yamaga, Kazumasa Miyatake, Jun Yamada, Yu Matsukura, Ichiro Sekiya, and Kunikazu Tsuji. BMP7 is prerequisite for postnatal joint homeostasis. The 6th Global COE International Symposium 2012.01.23 Tokyo, Japan

Tsuji K., Sekiya I., Muneta T. BMP4 Regulates the Hematopoietic Stem Cell Niche Size in Bone Marrow.. American Society for Bone and Mineral Research 2011.09.16 San Diego, CA USA

辻邦和. Roles of BMPs during skeletal development and in postnatal bone homeostasis. The 3rd International Conference on Oral Biology (TICOB) 2011.05.26 Bangkok, Thailand

辻邦和. 歯と骨のGCOE拠点　総合プレゼンテーション. 2011.03.05 東京医科歯科大学

Takahashi T, Muneta T, Tsuji K, Sekiya I. BMP-7 inhibits cartilage degeneration through suppression of inflammation in rat zymosan-induced arthritis. 57th Annual Meeting of the Orthopaedic Research Society 2011.01.13 Long Beach, CA, USA

Miyatake, K,Yamaga, M　Sekiya, I 　Muneta, T and Tsuji, K. Human chitinase 3-like protein 2 (YKL39); an osteoarthritis-associated gene which enhances adipogenic differentiation of synovial fibroblasts. Orthopaedic Research Society 2011 2011.01.13 Long Beach, CA