基本情報

写真a

田中 光一(タナカ コウイチ)

TANAKA Kohichi


職名

教授

生年

1958年

研究室住所

東京都文京区湯島1−5−45

研究室電話番号

03-5803-5846

研究室FAX番号

03-5803-5843

メールアドレス

tanaka.aud@mri.tmd.ac.jp

ホームページ

http://www.tmd.ac.jp/mri/aud/index.html

研究分野・キーワード

グルタミン酸 トランスポーター 遺伝子改変マウス 精神疾患 神経変性疾患

出身学校 【 表示 / 非表示

  • 新潟大学  医学部  医学科  1984年  卒業

出身大学院 【 表示 / 非表示

  • 新潟大学  医学研究科  神経化学  博士課程  1990年  修了

取得学位 【 表示 / 非表示

  • 医学博士  新潟大学

経歴(学内) 【 表示 / 非表示

  • 1998年09月
    -
    2022年04月
    東京医科歯科大学 難治疾患研究所 先端分子医学研究部門 分子神経科学 教授
  • 2022年05月
    -
    現在
    東京医科歯科大学 難治疾患研究所 病態制御科学研究部門 分子神経科学分野 教授

経歴(学外) 【 表示 / 非表示

  • 1984年06月
    -
    1984年08月
    新潟大学 医学部附属病院 臨床研修医
  • 1984年09月
    -
    1986年03月
    佐賀医科大学 生理学教室 助教
  • 1990年04月
    -
    1993年05月
    理化学研究所 国際フロンティア思考ネットワーク 基礎科学特別研究員
  • 1993年06月
    -
    1998年08月
    国立精神神経センター 神経研究所疾病研究第四部 室長

所属学協会 【 表示 / 非表示

  • 日本神経科学会 日本生理学会 日本神経化学会 北米神経科学会

研究分野 【 表示 / 非表示

  • 神経科学一般

 

研究テーマ 【 表示 / 非表示

  • 精神神経疾患の病態解明と新規治療法の開発,1993年

競争的資金等の研究課題 【 表示 / 非表示

  • アストロサイトから神経細胞への分化転換を用いた神経回路の機能的再建

    文部科学省/日本学術振興会 : 2021年 - 2023年

  • 神経活動をゲノムに記録するシステムの開発

    文部科学省/日本学術振興会 : 2018年 - 2020年

  • 線条体の回路特異的アストロサイトーニューロン連関の役割

    文部科学省/日本学術振興会 : 2017年 - 2019年

  • アストロサイトによる体温調節機序の解明

    文部科学省/日本学術振興会 : 2016年 - 2017年

  • アストロサイトの多様性の分子基盤解明

    文部科学省/日本学術振興会 : 2014年 - 2016年

  • 緑内障統合的分子診断法の確立と実証

    厚生労働省 : 2012年04月 - 2015年03月

▼全件表示

論文・総説 【 表示 / 非表示

  1. Peng Yubo, Tsuno Yusuke, Matsui Ayako, Hiraoka Yuichi, Tanaka Kohichi, Horike Shin-ichi, Daikoku Takiko, Mieda Michihiro. Cell Type-Specific Genetic Manipulation and Impaired Circadian Rhythms in Vip(tTA) Knock-In Mice FRONTIERS IN PHYSIOLOGY. 2022.05; 13 895633. ( PubMed, DOI )

  2. Morizawa Y, Matsumoto M, Nakashima Y, Endo N, Aida T, Ishikane H, Beppu K, Moritoh S, Inada H, Osumi N, Shigetomi E, Koizumi S, Yang G, Hirai H, Tanaka K, Tanaka KF, Ohno N, Fukazawa Y, Matsui K. Synaptic pruning through glial synapse engulfment during motor learning Nature Neuroscience. 2022;

  3. Ishida S, Zhao D, Sawada Y, Hiraoka Y, Mashimo T, Tanaka K. Dorsal telencephalon-specific Nprl2- and Nprl3-knockout mice: novel mouse models for GATORopathy. Human molecular genetics. 2021.11; 31 (9): 1519-1530. ( PubMed, DOI )

  4. Uchida M, Noda Y, Hasegawa S, Hida H, Taniguchi M, Mouri A, Yoshimi A, Nabeshima T, Yamada K, Aida T, Tanaka K, Ozaki N. Early postnatal inhibition of GLAST causes abnormalities of psychobehaviors and neuronal morphology in adult mice. Neurochemistry international. 2021.09; 150 105177. ( PubMed, DOI )

  5. Eshiba Sally, Namiki Takeshi, Mohri Yasuaki, Aida Tomomi, Serizawa Naotaka, Shibata Takakazu, Morinaga Hironobu, Nanba Daisuke, Hiraoka Yuichi, Tanaka Kohichi, Miura Keiko, Tanaka Masaru, Uhara Hisashi, Yokozeki Hiroo, Saida Toshiaki, Nishimura Emi K.. Stem cell spreading dynamics intrinsically differentiate acral melanomas from nevi CELL REPORTS. 2021.08; 36 (5): 109492. ( PubMed, DOI )

  6. Guo Xinzheng, Zhou Jing, Starr Christopher, Mohns Ethan J., Li Yidong, Chen Earnest P., Yoon Yonejung, Kellner Christopher P., Tanaka Kohichi, Wang Hongbing, Liu Wei, Pasquale Louis R., Demb Jonathan B., Crair Michael C., Chen Bo. Preservation of vision after CaMKII-mediated protection of retinal ganglion cells CELL. 2021.08; 184 (16): 4299-+. ( PubMed, DOI )

  7. Hiraoka Yuichi, Sugiyama Kaori, Nagaoka Daiki, Tsutsui-Kimura Iku, Tanaka Kenji F., Tanaka Kohichi. Mice with reduced glutamate transporter GLT1 expression exhibit behaviors related to attention-deficit/hyperactivity disorder BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2021.08; 567 161-165. ( PubMed, DOI )

  8. Nagaishi T, Watabe T, Kotake K, Kumazawa T, Aida T, Tanaka K, Ono R, Ishino F, Usami T, Miura T, Hirakata S, Kawasaki H, Tsugawa N, Yamada D, Hirayama K, Yoshikawa S, Karasuyama H, Okamoto R, Watanabe M, Blumberg RS, Adachi T. Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum. Gut. 2021.05; 71 (3): 487-496. ( PubMed, DOI )

  9. Tadashi Shin, Yuichi Hiraoka, Tokiwa Yamasaki, Jamey D Marth, Josef M Penninger, Masami Kanai-Azuma, Kohichi Tanaka, Satoshi Kofuji, Hiroshi Nishina. MKK7 deficiency in mature neurons impairs parental behavior in mice. Genes Cells. 2021.01; 26 (1): 5-17. ( PubMed, DOI )

  10. Mariko Onodera, Jan Meyer, Kota Furukawa, Yuichi Hiraoka, Tomomi Aida, Kohichi Tanaka, Kenji F Tanaka, Christine R Rose, Ko Matsui. Exacerbation of epilepsy by astrocyte alkalization and gap junction uncoupling. J Neurosci. 2021.01; 41 2106-2118. ( PubMed, DOI )

  11. Tanaka K. Astroglia and Obsessive Compulsive Disorder. Advances in neurobiology. 2021; 26 139-149. ( PubMed, DOI )

  12. Hidenori Aizawa, Weinan Sun, Kaori Sugiyama, Yukiko Itou, Tomomi Aida, Wanpeng Cui, Saori Toyoda, Haruhi Terai, Michiko Yanagisawa, Kohichi Tanaka. Glial glutamate transporter GLT-1 determines susceptibility to spreading depression in the mouse cerebral cortex. Glia. 2020.12; 68 (12): 2631-2642. ( PubMed, DOI )

  13. Yoshifumi Abe, Norio Takata, Yuki Sakai, Hiro Taiyo Hamada, Yuichi Hiraoka, Tomomi Aida, Kohichi Tanaka, Denis Le Bihan, Kenji Doya, Kenji F Tanaka. Diffusion functional MRI reveals global brain network functional abnormalities driven by targeted local activity in a neuropsychiatric disease mouse model. Neuroimage. 2020.12; 223 117318. ( PubMed, DOI )

  14. Wanpeng Cui, Tomomi Aida, Hikaru Ito, Kenta Kobayashi, Yusaku Wada, Shigeki Kato, Takashi Nakano, Meina Zhu, Kaoru Isa, Kazuto Kobayashi, Tadashi Isa, Kohichi Tanaka, Hidenori Aizawa. Dopaminergic Signaling in the Nucleus Accumbens Modulates Stress-Coping Strategies during Inescapable Stress. J Neurosci. 2020.09; 40 (38): 7241-7254. ( PubMed, DOI )

  15. Michiko Yanagisawa, Kazuhiko Namekata, Tomomi Aida, Sayaka Katou, Takuya Takeda, Takayuki Harada, Nobuo Fuse, The Glaucoma Gene Research Group, Kohichi Tanaka. EAAT1 variants associated with glaucoma. Biochem Biophys Res Commun. 2020.09; 529 (4): 943-949. ( PubMed, DOI )

  16. Mariko Sekiguchi, Akira Sobue, Itaru Kushima, Chenyao Wang, Yuko Arioka, Hidekazu Kato, Akiko Kodama, Hisako Kubo, Norimichi Ito, Masahito Sawahata, Kazuhiro Hada, Ryosuke Ikeda, Mio Shinno, Chikara Mizukoshi, Keita Tsujimura, Akira Yoshimi, Kanako Ishizuka, Yuto Takasaki, Hiroki Kimura, Jingrui Xing, Yanjie Yu, Maeri Yamamoto, Takashi Okada, Emiko Shishido, Toshiya Inada, Masahiro Nakatochi, Tetsuya Takano, Keisuke Kuroda, Mutsuki Amano, Branko Aleksic, Takashi Yamomoto, Tetsushi Sakuma, Tomomi Aida, Kohichi Tanaka, Ryota Hashimoto, Makoto Arai, Masashi Ikeda, Nakao Iwata, Teppei Shimamura, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Kiyofumi Yamada, Daisuke Mori, Norio Ozaki. ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk. Transl Psychiatry. 2020.07; 10 (1): 247. ( PubMed, DOI )

  17. Yoshiko Aihara, Yota Fukuda, Akiyoshi Takizawa, Naomi Osakabe, Tomomi Aida, Kohichi Tanaka, Soichiro Yoshikawa, Hajime Karasuyama, Takahiro Adachi. Visualization of mechanical stress-mediated Ca 2+ signaling in the gut using intravital imaging Biosci Microbiota Food Health. 2020.06; 39 (4): 209-218. ( PubMed, DOI )

  18. Tomoka Takao, Yuichi Hiraoka, Kenji Kawabe, Daisuke Yamada, Lu Ming, Kohichi Tanaka, Moritoshi Sato, Takeshi Takarada. Establishment of a tTA-dependent photoactivatable Cre recombinase knock-in mouse model for optogenetic genome engineering. Biochem Biophys Res Commun. 2020.05; 526 (1): 213-217. ( PubMed, DOI )

  19. Uchida Mizuki, Hida Hirotake, Mori Kentaro, Yoshimi Akira, Kitagaki Shinji, Yamada Kiyofumi, Hiraoka Yuichi, Aida Tomomi, Tanaka Kohichi, Ozaki Norio, Noda Yukihiro. Functional roles of the glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019.08; 29 (8): 914-924. ( PubMed, DOI )

  20. Nakade S, Mochida K, Kunii A, Nakamae K, Aida T, Tanaka K, Sakamoto N, Sakuma T, Yamamoto T. Biased genome editing using the local accumulation of DSB repair molecules system. Nature communications. 2018.08; 9 (1): 3270. ( PubMed, DOI )

  21. Bettina Reichenbach, Johanna Classon, Tomomi Aida, Kohichi Tanaka, Maria Genander, Christian Göritz. Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth. EMBO J.. 2018.05; 37 (9): e98280. ( PubMed, DOI )

  22. Emma M Perkins, Yvonne L Clarkson, Daumante Suminaite, Alastair R Lyndon, Kohichi Tanaka, Jeffrey D Rothstein, Paul Skehel, David J A Wyllie, Mandy Jackson. Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells. Hum. Mol. Genet.. 2018.05; 27 (15): 2614-2627. ( PubMed, DOI )

  23. Zhuoyang Zhao, Yuichi Hiraoka, Hiroshi Ogawa, Kohichi Tanaka. Region-specific deletions of the glutamate transporter GLT1 differentially affect nerve injury-induced neuropathic pain in mice. Glia. 2018.05; 66 (9): 1988-1998. ( PubMed, DOI )

  24. Junya Sugimoto, Moeko Tanaka, Kaori Sugiyama, Yukiko Ito, Hidenori Aizawa, Miho Soma, Tomoko Shimizu, Akira Mitani, Kohichi Tanaka. Region-specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice. Glia. 2018.04; 66 (4): 777-788. ( PubMed, DOI )

  25. Kaori Sugiyama, Kohichi Tanaka. Spinal cord-specific deletion of the glutamate transporter GLT1 causes motor neuron death in mice. Biochem. Biophys. Res. Commun.. 2018.03; 497 (2): 689-693. ( PubMed, DOI )

  26. Kaori Sugiyama, Tomomi Aida, Masatoshi Nomura, Ryoichi Takayanagi, Hanns U Zeilhofer, Kohichi Tanaka. Calpain-Dependent Degradation of Nucleoporins Contributes to Motor Neuron Death in a Mouse Model of Chronic Excitotoxicity. J. Neurosci.. 2017.09; 37 (36): 8830-8844. ( PubMed, DOI )

  27. Taisuke Miyazaki, Miwako Yamasaki, Kouichi Hashimoto, Kazuhisa Kohda, Michisuke Yuzaki, Keiko Shimamoto, Kohichi Tanaka, Masanobu Kano, Masahiko Watanabe. Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells. Proc. Natl. Acad. Sci. U.S.A.. 2017.07; 114 (28): 7438-7443. ( PubMed, DOI )

  28. Ken-Ichiro Kubo, Kimiko Deguchi, Taku Nagai, Yukiko Ito, Keitaro Yoshida, Toshihiro Endo, Seico Benner, Wei Shan, Ayako Kitazawa, Michihiko Aramaki, Kazuhiro Ishii, Minkyung Shin, Yuki Matsunaga, Kanehiro Hayashi, Masaki Kakeyama, Chiharu Tohyama, Kenji F Tanaka, Kohichi Tanaka, Sachio Takashima, Masahiro Nakayama, Masayuki Itoh, Yukio Hirata, Barbara Antalffy, Dawna D Armstrong, Kiyofumi Yamada, Ken Inoue, Kazunori Nakajima. Association of impaired neuronal migration with cognitive deficits in extremely preterm infants. JCI Insight. 2017.05; 2 (10): ( PubMed, DOI )

  29. Tomoharu Nakamori, Tomomi Kato, Hiroyuki Sakagami, Kohichi Tanaka, Hiroko Ohki-Hamazaki. Regulation of visual Wulst cell responsiveness by imprinting causes stimulus-specific activation of rostral cells. Sci Rep. 2017.02; 7 42927. ( PubMed, DOI )

  30. Tomomi Aida, Shota Nakade, Tetsushi Sakuma, Yayoi Izu, Ayu Oishi, Keiji Mochida, Harumi Ishikubo, Takako Usami, Hidenori Aizawa, Takashi Yamamoto, Kohichi Tanaka. Gene cassette knock-in in mammalian cells and zygotes by enhanced MMEJ. BMC Genomics. 2016.11; 17 (1): 979. ( PubMed, DOI )

  31. Zhenyu Dong, Yasuhiro Shinmei, Yoko Dong, Saori Inafuku, Junichi Fukuhara, Ryo Ando, Nobuyoshi Kitaichi, Atsuhiro Kanda, Kohichi Tanaka, Kousuke Noda, Takayuki Harada, Shinki Chin, Susumu Ishida. Effect of geranylgeranylacetone on the protection of retinal ganglion cells in a mouse model of normal tension glaucoma. Heliyon. 2016.10; 2 (10): e00191. ( PubMed, DOI )

  32. Emma M Perkins, Daumante Suminaite, Yvonne L Clarkson, Sin Kwan Lee, Alastair R Lyndon, Jeffrey D Rothstein, David J A Wyllie, Kohichi Tanaka, Mandy Jackson. Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST. Hum. Mol. Genet.. 2016.10; 25 (20): 4448-4461. ( PubMed, DOI )

  33. Ageta-Ishihara, N., Yamazaki, M., Konno, K., Nakayama, H., Abe, M., Hashimoto, K., Nishioka, T., Kaibuchi, K., Hattori, S., Miyakawa, T., Tanaka, K., Huda, F., Hrai, H., Hashimoto, K., Watanabe, M., Sakimura, K., Kinoshita, M.. A CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance. Nature Commun. 2015.12; 6 10090. ( PubMed, DOI )

  34. Ishii, K., Kubo, K., Endo, T., Yoshida, K., Benner, S., Ito, Y., Aizawa, H., Aramaki, M., Yamanaka, A., Tanaka, K., Takata, N., Tanaka, K., Mimura, M., Tohyama, C., Kakeyama, M., Nakajima, K.. Neuronal heterotopias affect the activities of distant brain areas and lead to behavioral deficits. J Neurosci. 2015.09; 35 (36): 12432-12445. ( PubMed, DOI )

  35. Aida, T., Yoshida, J., Nomura, M., Tanimura, A., Iino, Y., Soma, M., Bai, N., Ito, Y., Cui, W., Aizawa, H., Yanagisawa, M., Nagai, T., Takata, N., Tanaka, KF., Takayanagi, R., Kano, M., Gotz, M., Hirase, H., Tanaka, K.. Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice. Neuropsychopharmacology. 2015.06; 40 (7): 1569-1579. ( PubMed, DOI )

  36. Aida T, Chiyo K, Usami T, Ishikubo H, Imahashi R, Wada Y, Tanaka KF, Sakuma T, Yamamoto T, Tanaka K.. Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice. Genome Biol. 2015.04; 16 87. ( PubMed, DOI )

  37. Yanagisawa, M., Aida, T., Takeda,T., Namekata, K., Harada, T., Shinagawa, R., Tanaka, K. . Arundic acid attenuates retinal ganglion cell death by increasing glutamate/aspartate transporter expression in a model of normal tension glaucoma. Cell Death Dis. 2015.03; 6 e1693. ( PubMed, DOI )

  38. Kimura, A., Guo, X., Noro, T., Harada, C., Tanaka, K., Namekata, K., Harada, T. Valproic acid prevents retinal degeneration in a murine model of normal tension glaucoma. Neurosci Lett. 2015.02; 588 108-113.

  39. Nakamori, T., Sato, K., Kinoshita, M., Kanamatsu, T., Sakagami, H., Tanaka, K., Ohki-Hamazaki, H. . Positive feedback of NR2B-containing NMDA receptor activity is the initial step toward visual imprinting: a model for juvenile learning. J Neurochem. 2015.01; 132 (1): 110-123.

  40. Cui, W., Mizukami, H., Yanagisawa, M., Aida, T., Nomura, M., Isomura, Y., Takayanagi, R., Ozawa, K., Tanaka, K., Aizawa, H. . Glial dysfunction in the mouse habenula causes depressive-like behaviors and sleep disturbance. J Neurosci. 2014.12; 34 (49): 16273-16285.

  41. Schreiner, AE., Durry, S., Aida, T., Stock, MC., Ruther, U., Tanaka, K., Rose, CR. Kafitz, KW.. Laminar and subcellular heterogeneity of GLAST and GLT-1 immunoreactivity in the developing postnatal mouse hippocampus. J Comp Neurol. 2014.01; 522 (1): 204-224.

  42. Aida, T., Imahashi, R., Tanaka, K. . Translating human genetics into mouse: The impact of ultra-rapid in vivo genome editing. Dev Growth Differ. 2014; 56 34-45.

  43. Namekata, K., Kimura, A., Kawamura, K., Guo, X., Harada, C., Tanaka, K., Harada, T.. Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma. Cell Death Differ. 2013.09; 20 (9): 1250-1256.

  44. Bai, N., Aida, T., Yanagisawa, M., Katou, S., Sakimura, K., Mishina, M., Tanaka K.. NMDA receptor subunits have differential roles in NMDA-induced neurotoxicity in the retina. Mol Brain. 2013.07; 6 34.

  45. Bai, N., Hayashi, H., Aida, T., Namekata, K., Harada, T., Mishina, M., Tanaka, K. . Dock3 interaction with a glutamate-receptor NR2D subunit preotects neurons from excitotoxicity. Mol Brain. 2013.05; 6 22.

  46. Hiraoka, Y., Komine, O., Nagaoka, M., Bai, N., Hozumi, K., Tanaka, K.. Delta like 1 regulates Bergmann glial differentiation during cerebellar development. Mol Brain. 2013.05; 6 25.

  47. Maekawa, F., Sakurai, M., Yamashita, Y., Tanaka, K., Haraguchi, S., Yamamoto, K., Tsutsui, K., Yoshioka, H., Mutakami, S., Maeda, T., Tadano, R., Goto, T., Tomonari, K., Oka, T., Ohara, K., Shiraishi, J., Bungo, T., Tsudzuki, M., Ohki-Hamazki, H.. A genetically female brain is required for a regular reproductive cycle in chicken brain chimeras. Nature Commun. 2013.01; 4 1372.

  48. Nakamori, T., Maekawa, F., Sato, K., Tanaka, K., Ohki-Hamazaki, H. . Neural basis of imprinting behavior in chicks. Dev Growth Differ. 2013.01; 55 198-206.

  49. Aizawa, H., Cui, W., Tanaka, K., Okamoto, H.. Hyperactivation of the habenula as a link between depression and sleep disturbance. Front Hum Neurosci. 2013; 7 826.

  50. Suzuki, K., Maekawa, F., Suzuki, S., Nakamoi, T., Sugiyama, H., Kanamatsu, T., Tanaka, K., Ohki-Hamazaki, H.. Elevated expression of brain-derived neurotrophic factor facilitates visual imprinting in chicks. J Neurochem. 2012.12; 123 (5): 800-810.

  51. Karlsson, R-M., Adwmark, L., Molander, A., Perreau-Lenz, S., Singley, E., Solomon, M., Holmes, A., Tanaka, K., Lovinger, DM., Spanagel, R., Heiling, M. . Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST. Neuropharmacology. 2012.08; 63 (2): 181-189.

  52. Hayashi, H., Eguchi, Y., Fukuchi-Nakanishi, Y., Takeya, M., Nakagata, N., Tanaka, K., Vance, JE., Tanihara, H. . A potential therapeutic function of apolipoprotein E-containing lipoproteins for normal tension glaucoma. J Biol Chem. 2012.06; 287 (30): 25395-25406.

  53. Aida, T., Ito, Y., Takahashi, YK., Tanaka, K.. Overstimulation of NMDA Receptors Impairs Early Brain Development in vivo. PlosOne. 2012.05; 7 eE36853.

  54. Tsai, M-C., Tanaka, K., Overstreet-Wadiche, L., Wadiche, JI.. Neuronal glutamate transporters regulate glial excitatory transmission. J Neurosci. 2012.02; 32 (5): 1528-1535.

  55. Komine, O., Nagaoka, M., Hiraoka, Y., Hoshino, M., Kawaguchi, Y., Pear, E.S., Tanaka, K.. RBP-J promotes the maturation of neuronal progenitors. Dev Biol. 2011.06; 354 (1): 44-54.

  56. Mookherjee, P., Green, P.S., Watson, G.S., Marques, M.A., Tanaka, K., Meeker, K.D., Meabon, J.S., Li, N., Zhu, P., Olson, V.G., Cook, D.G.. GLT-1 loss accelerates cognitive deficits onset in an Alzheimer’s disease animal model. J Alzheimers Dis. 2011.06; 26 (3): 447-455.

  57. Harada C, Guo X, Namekata K, Kimura A, Nakamura K, Tanaka K, Parada LF, Harada T. Glia- and neuron-specific functions of TrkB signalling during retinal degeneration and regeneration. Nat Commun. 2011.02; 2 189. ( PubMed, DOI )

  58. Harada C, Namekata K, Guo X, Yoshida H, Mitamura Y, Matsumoto Y, Tanaka K, Ichijo H, Harada T. ASK1 deficiency attenuates neural cell death in GLAST-deficient mice, a model of normal tension glaucoma. Cell Death Differ. 2010.11; 17 (11): 1751-1759. ( PubMed, DOI )

  59. Woltjer RL, Duerson K, Fullmer JM, Mookherjee P, Ryan AM, Montine TJ, Kaye JA, Quinn JF, Silbert L, Erten-Lyons D, Leverenz JB, Bird TD, Pow DV, Tanaka K, Watson GS, Cook DG. Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease. J Neuropathol Exp Neurol. 2010.07; 69 (7): 667-676. ( PubMed, DOI )

  60. Paukert M, Huang YH, Tanaka K, Rothstein JD, Bergles DE. Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum. J Neurosci. 2010.05; 30 (21): 7290-7299. ( PubMed, DOI )

  61. Swartling FJ, Grimmer MR, Hackett CS, Northcott PA, Fan QW, Goldenberg DD, Lau J, Masic S, Nguyen K, Yakovenko S, Zhe XN, Gilmer HC, Collins R, Nagaoka M, Phillips JJ, Jenkins RB, Tihan T, Vandenberg SR, James CD, Tanaka K, Taylor MD, Weiss WA, Chesler L. Pleiotropic role for MYCN in medulloblastoma. Genes Dev. 2010.05; 24 (10): 1059-1072. ( PubMed, DOI )

  62. Nakamori T, Sato K, Atoji Y, Kanamatsu T, Tanaka K, Ohki-Hamazaki H. Demonstration of a neural circuit critical for imprinting behavior in chicks. J Neurosci. 2010.03; 30 (12): 4467-4480. ( PubMed, DOI )

  63. Namekata K, Harada C, Guo X, Kikushima K, Kimura A, Fuse N, Mitamura Y, Kohyama K, Matsumoto Y, Tanaka K, Harada T. Interleukin-1 attenuates normal tension glaucoma-like retinal degeneration in EAAC1-deficient mice. Neurosci Lett. 2009.11; 465 (2): 160-164. ( PubMed, DOI )

  64. Omrani A, Melone M, Bellesi M, Safiulina V, Aida T, Tanaka K, Cherubini E, Conti F. Up-regulation of GLT-1 severely impairs LTD at mossy fibre--CA3 synapses. J Physiol (Lond). 2009.10; 587 (Pt 19): 4575-4588. ( PubMed, DOI )

  65. Takayasu Y, Iino M, Takatsuru Y, Tanaka K, Ozawa S. Functions of glutamate transporters in cerebellar Purkinje cell synapses. Acta Physiol (Oxf). 2009.09; 197 (1): 1-12. ( PubMed, DOI )

  66. Karlsson RM, Tanaka K, Saksida LM, Bussey TJ, Heilig M, Holmes A. Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia. Neuropsychopharmacology. 2009.05; 34 (6): 1578-1589. ( PubMed, DOI )

  67. Soma, M., Aizawa, H., Ito, Y., Maekawa, M., Osumi, N., Nakahira, E., Okamoto, H., Tanaka, K., Yuasa, S.. Development of the mouse amygdala as revealed by enhanced green fluorescent protein gene transfer by means of in utero electroporation. J Comp Neurol. 2009; 513 113-128.

  68. Karlsson RM, Tanaka K, Heilig M, Holmes A. Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist. Biol Psychiatry. 2008.11; 64 (9): 810-814. ( PubMed, DOI )

  69. Takasaki C, Okada R, Mitani A, Fukaya M, Yamasaki M, Fujihara Y, Shirakawa T, Tanaka K, Watanabe M. Glutamate transporters regulate lesion-induced plasticity in the developing somatosensory cortex. J Neurosci. 2008.05; 28 (19): 4995-5006. ( PubMed, DOI )

  70. Kiryk A, Aida T, Tanaka K, Banerjee P, Wilczynski GM, Meyza K, Knapska E, Filipkowski RK, Kaczmarek L, Danysz W. Behavioral characterization of GLT1 (+/-) mice as a model of mild glutamatergic hyperfunction. Neurotox Res. 2008.01; 13 (1): 19-30. ( PubMed )

  71. Komine O, Nagaoka M, Watase K, Gutmann DH, Tanigaki K, Honjo T, Radtke F, Saito T, Chiba S, Tanaka K. The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling. Dev Biol. 2007.11; 311 (1): 238-250. ( PubMed, DOI )

  72. Nikkuni O, Takayasu Y, Iino M, Tanaka K, Ozawa S. Facilitated activation of metabotropic glutamate receptors in cerebellar Purkinje cells in glutamate transporter EAAT4-deficient mice. Neurosci Res. 2007.11; 59 (3): 296-303. ( PubMed, DOI )

  73. Maekawa F, Nakamori T, Uchimura M, Fujiwara K, Yada T, Tsukahara S, Kanamatsu T, Tanaka K, Ohki-Hamazaki H. Activation of cholecystokinin neurons in the dorsal pallium of the telencephalon is indispensable for the acquisition of chick imprinting behavior. J Neurochem. 2007.09; 102 (5): 1645-1657. ( PubMed, DOI )

  74. Harada T, Harada C, Nakamura K, Quah HM, Okumura A, Namekata K, Saeki T, Aihara M, Yoshida H, Mitani A, Tanaka K. The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. J Clin Invest. 2007.07; 117 (7): 1763-1770. ( PubMed, DOI )

  75. Takatsuru Y, Iino M, Tanaka K, Ozawa S. Contribution of glutamate transporter GLT-1 to removal of synaptically released glutamate at climbing fiber-Purkinje cell synapses. Neurosci Lett. 2007.06; 420 (1): 85-89. ( PubMed, DOI )

  76. Okumichi H, Kanamoto T, Souchelnytskyi N, Tanimoto S, Tanaka K, Kiuchi Y. Proteomic analyses of retina of excitatory amino acid carrier 1 deficient mice. Proteome Sci. 2007; 5 13. ( PubMed, DOI )

  77. Pardo AC, Wong V, Benson LM, Dykes M, Tanaka K, Rothstein JD, Maragakis NJ. Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice. Exp Neurol. 2006.09; 201 (1): 120-130. ( PubMed, DOI )

  78. Matsugami TR, Tanemura K, Mieda M, Nakatomi R, Yamada K, Kondo T, Ogawa M, Obata K, Watanabe M, Hashikawa T, Tanaka K. From the Cover: Indispensability of the glutamate transporters GLAST and GLT1 to brain development. Proc Natl Acad Sci USA. 2006.08; 103 (32): 12161-12166. ( PubMed, DOI )

  79. Glowatzki E, Cheng N, Hiel H, Yi E, Tanaka K, Ellis-Davies GC, Rothstein JD, Bergles DE. The glutamate-aspartate transporter GLAST mediates glutamate uptake at inner hair cell afferent synapses in the mammalian cochlea. J Neurosci. 2006.07; 26 (29): 7659-7664. ( PubMed, DOI )

  80. Yamashita A, Makita K, Kuroiwa T, Tanaka K. Glutamate transporters GLAST and EAAT4 regulate postischemic Purkinje cell death: an in vivo study using a cardiac arrest model in mice lacking GLAST or EAAT4. Neurosci Res. 2006.07; 55 (3): 264-270. ( PubMed, DOI )

  81. Kiryu-Seo S, Gamo K, Tachibana T, Tanaka K, Kiyama H. Unique anti-apoptotic activity of EAAC1 in injured motor neurons. EMBO J. 2006.07; 25 (14): 3411-3421. ( PubMed, DOI )

  82. Mori T, Tanaka K, Buffo A, Wurst W, Kühn R, Götz M. Inducible gene deletion in astroglia and radial glia--a valuable tool for functional and lineage analysis. Glia. 2006.07; 54 (1): 21-34. ( PubMed, DOI )

  83. Takayasu Y, Iino M, Shimamoto K, Tanaka K, Ozawa S. Glial glutamate transporters maintain one-to-one relationship at the climbing fiber-Purkinje cell synapse by preventing glutamate spillover. J Neurosci. 2006.06; 26 (24): 6563-6572. ( PubMed, DOI )

  84. Hasegawa J, Obara T, Tanaka K, Tachibana M. High-density presynaptic transporters are required for glutamate removal from the first visual synapse. Neuron. 2006.04; 50 (1): 63-74. ( PubMed, DOI )

  85. Takatsuru Y, Takayasu Y, Iino M, Nikkuni O, Ueda Y, Tanaka K, Ozawa S. Roles of glial glutamate transporters in shaping EPSCs at the climbing fiber-Purkinje cell synapses. Neurosci Res. 2006.02; 54 (2): 140-148. ( PubMed, DOI )

  86. Harada C, Harada T, Nakamura K, Sakai Y, Tanaka K, Parada LF. Effect of p75NTR on the regulation of naturally occurring cell death and retinal ganglion cell number in the mouse eye. Dev Biol. 2006.02; 290 (1): 57-65. ( PubMed, DOI )

  87. Harada C, Nakamura K, Namekata K, Okumura A, Mitamura Y, Iizuka Y, Kashiwagi K, Yoshida K, Ohno S, Matsuzawa A, Tanaka K, Ichijo H, Harada T. Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo. Am J Pathol. 2006.01; 168 (1): 261-269. ( PubMed, DOI )

  88. Mieda, M., Williams, S.C., Richardson, J.A., Tanaka, K., Yanagisawa, M.. The dorsomedial hypothalamic nucleus as a food-entrainable circadian pacemaker. Proc Natl Acad Sci USA. 2006; 103 12150-12155.

  89. Iwabuchi M, Maekawa F, Tanaka K, Ohki-Hamazaki H. Overexpression of gastrin-releasing peptide receptor induced layer disorganization in brain. Neuroscience. 2006; 138 (1): 109-122. ( PubMed, DOI )

  90. Maekawa F, Komine O, Sato K, Kanamatsu T, Uchimura M, Tanaka K, Ohki-Hamazaki H. Imprinting modulates processing of visual information in the visual wulst of chicks. BMC Neurosci. 2006; 7 75. ( PubMed, DOI )

  91. Herard AS, Dubois A, Escartin C, Tanaka K, Delzescaux T, Hantraye P, Bonvento G. Decreased metabolic response to visual stimulation in the superior colliculus of mice lacking the glial glutamate transporter GLT-1. Eur J Neurosci. 2005.10; 22 (7): 1807-1811. ( PubMed, DOI )

  92. Takayasu Y, Iino M, Kakegawa W, Maeno H, Watase K, Wada K, Yanagihara D, Miyazaki T, Komine O, Watanabe M, Tanaka K, Ozawa S. Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses. J Neurosci. 2005.09; 25 (38): 8788-8793. ( PubMed, DOI )

  93. Harada C, Harada T, Quah HM, Namekata K, Yoshida K, Ohno S, Tanaka K, Parada LF. Role of neurotrophin-4/5 in neural cell death during retinal development and ischemic retinal injury in vivo. Invest Ophthalmol Vis Sci. 2005.02; 46 (2): 669-673. ( PubMed, DOI )

  94. Sarthy VP, Pignataro L, Pannicke T, Weick M, Reichenbach A, Harada T, Tanaka K, Marc R. Glutamate transport by retinal Muller cells in glutamate/aspartate transporter-knockout mice. Glia. 2005.01; 49 (2): 184-196. ( PubMed, DOI )

  95. Tanaka K. Antibiotics rescue neurons from glutamate attack. Trends Mol Med. 2005; 11 259-262.

  96. Sarthy VP, Marc RE, Pignataro L, Tanaka K. Contribution of a glial glutamate transporter to GABA synthesis in the retina. Neuroreport. 2004.08; 15 (12): 1895-1898. ( PubMed )

  97. Huang YH, Sinha SR, Tanaka K, Rothstein JD, Bergles DE. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci. 2004.05; 24 (19): 4551-4559. ( PubMed, DOI )

  98. Maekawa F, Quah HM, Tanaka K, Ohki-Hamazaki H. Leptin resistance and enhancement of feeding facilitation by melanin-concentrating hormone in mice lacking bombesin receptor subtype-3. Diabetes. 2004.03; 53 (3): 570-576. ( PubMed )

  99. Chen W, Mahadomrongkul V, Berger UV, Bassan M, DeSilva T, Tanaka K, Irwin N, Aoki C, Rosenberg PA. The glutamate transporter GLT1a is expressed in excitatory axon terminals of mature hippocampal neurons. J Neurosci. 2004.02; 24 (5): 1136-1148. ( PubMed, DOI )

  100. Huang YH, Dykes-Hoberg M, Tanaka K, Rothstein JD, Bergles DE. Climbing fiber activation of EAAT4 transporters and kainate receptors in cerebellar Purkinje cells. J Neurosci. 2004.01; 24 (1): 103-111. ( PubMed, DOI )

  101. Harada T, Harada C, Wang YL, Osaka H, Amanai K, Tanaka K, Takizawa S, Setsuie R, Sakurai M, Sato Y, Noda M, Wada K. Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo. Am J Pathol. 2004.01; 164 (1): 59-64. ( PubMed, DOI )

  102. Harada C, Harada T, Mitamura Y, Quah HM, Ohtsuka K, Kotake S, Ohno S, Wada K, Takeuchi S, Tanaka K. Diverse NF-kappaB expression in epiretinal membranes after human diabetic retinopathy and proliferative vitreoretinopathy. Mol Vis. 2004.01; 10 31-36. ( PubMed )

  103. Sarthy VP, Dudley VJ, Tanaka K. Retinal glucose metabolism in mice lacking the L-glutamate/aspartate transporter. Vis Neurosci. 2004; 21 (4): 637-643. ( PubMed, DOI )

  104. Maekawa F, Tsukahara S, Tanaka K, Ohki-Hamazaki H. Distributions of two chicken bombesin receptors, bombesin receptor subtype-3.5 (chBRS-3.5) and gastrin-releasing peptide receptor (chGRP-R) mRNAS in the chicken telencephalon. Neuroscience. 2004; 125 (3): 569-582. ( PubMed, DOI )

  105. Voutsinos-Porche B, Knott G, Tanaka K, Quairiaux C, Welker E, Bonvento G. Glial glutamate transporters and maturation of the mouse somatosensory cortex. Cereb Cortex. 2003.10; 13 (10): 1110-1121. ( PubMed )

  106. Mitani A, Tanaka K. Functional changes of glial glutamate transporter GLT-1 during ischemia: an in vivo study in the hippocampal CA1 of normal mice and mutant mice lacking GLT-1. J Neurosci. 2003.08; 23 (18): 7176-7182. ( PubMed )

  107. Jin ZH, Kikuchi T, Tanaka K, Kobayashi T. Expression of glutamate transporter GLAST in the developing mouse cochlea. Tohoku J Exp Med. 2003.07; 200 (3): 137-144. ( PubMed )

  108. Iwabuchi M, Ui-Tei K, Yamada K, Matsuda Y, Sakai Y, Tanaka K, Ohki-Hamazaki H. Molecular cloning and characterization of avian bombesin-like peptide receptors: new tools for investigating molecular basis for ligand selectivity. Br J Pharmacol. 2003.06; 139 (3): 555-566. ( PubMed, DOI )

  109. Mitamura Y, Harada T, Harada C, Ohtsuka K, Kotake S, Ohno S, Tanaka K, Takeuchi S, Wada K. NF-kappaB in epiretinal membranes after human diabetic retinopathy. Diabetologia. 2003.05; 46 (5): 699-703. ( PubMed, DOI )

  110. Voutsinos-Porche B, Bonvento G, Tanaka K, Steiner P, Welker E, Chatton JY, Magistretti PJ, Pellerin L. Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex. Neuron. 2003.01; 37 (2): 275-286. ( PubMed )

  111. Okada, T., Yamada, N., Tsuzuki, K., Horikawa, PM., Tanaka, K., and Ozawa, S. . Long-term potentiation in the hippocampal CA1 area and dentategyrus plays different roles in spatial learning. Eur J Neurosci. 2003; 17 341-349.

  112. Harada C, Harada T, Quah HM, Maekawa F, Yoshida K, Ohno S, Wada K, Parada LF, Tanaka K. Potential role of glial cell line-derived neurotrophic factor receptors in Müller glial cells during light-induced retinal degeneration. Neuroscience. 2003; 122 (1): 229-235. ( PubMed )

  113. Harada T, Harada C, Kohsaka S, Wada E, Yoshida K, Ohno S, Mamada H, Tanaka K, Parada LF, Wada K. Microglia-Müller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration. J Neurosci. 2002.11; 22 (21): 9228-9236. ( PubMed )

  114. Nishizaki T, Nagai K, Nomura T, Tada H, Kanno T, Tozaki H, Li XX, Kondoh T, Kodama N, Takahashi E, Sakai N, Tanaka K, Saito N. A new neuromodulatory pathway with a glial contribution mediated via A(2a) adenosine receptors. Glia. 2002.08; 39 (2): 133-147. ( PubMed, DOI )

  115. Katagiri H, Tanaka K, Manabe T. Requirement of appropriate glutamate concentrations in the synaptic cleft for hippocampal LTP induction. Eur J Neurosci. 2001.08; 14 (3): 547-553. ( PubMed )

  116. Sugiyama T, Sadzuka Y, Tanaka K, Sonobe T. Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin. Toxicol Lett. 2001.04; 121 (2): 89-96. ( PubMed )

  117. Gray C, Marie H, Arora M, Tanaka K, Boyde A, Jones S, Attwell D. Glutamate does not play a major role in controlling bone growth. J Bone Miner Res. 2001.04; 16 (4): 742-749. ( PubMed, DOI )

  118. Hakuba N, Koga K, Gyo K, Usami SI, Tanaka K. Exacerbation of noise-induced hearing loss in mice lacking the glutamate transporter GLAST. J Neurosci. 2000.12; 20 (23): 8750-8753. ( PubMed )

  119. Yamada K, Fukaya M, Shibata T, Kurihara H, Tanaka K, Inoue Y, Watanabe M. Dynamic transformation of Bergmann glial fibers proceeds in correlation with dendritic outgrowth and synapse formation of cerebellar Purkinje cells. J Comp Neurol. 2000.02; 418 (1): 106-120. ( PubMed )

  120. Tanaka K. Functions of glutamate transporters in the brain. Neurosci Res. 2000; 37 15-19.

  121. Mennerick S, Shen W, Xu W, Benz A, Tanaka K, Shimamoto K, Isenberg KE, Krause JE, Zorumski CF. Substrate turnover by transporters curtails synaptic glutamate transients. J Neurosci. 1999.11; 19 (21): 9242-9251. ( PubMed )

  122. Watanabe T, Morimoto K, Hirao T, Suwaki H, Watase K, Tanaka K. Amygdala-kindled and pentylenetetrazole-induced seizures in glutamate transporter GLAST-deficient mice. Brain Res. 1999.10; 845 (1): 92-96. ( PubMed )

  123. Fukaya M, Yamada K, Nagashima M, Tanaka K, Watanabe M. Down-regulated expression of glutamate transporter GLAST in Purkinje cell-associated astrocytes of reeler and weaver mutant cerebella. Neurosci Res. 1999.08; 34 (3): 165-175. ( PubMed )

  124. Kojima S, Nakamura T, Nidaira T, Nakamura K, Ooashi N, Ito E, Watase K, Tanaka K, Wada K, Kudo Y, Miyakawa H. Optical detection of synaptically induced glutamate transport in hippocampal slices. J Neurosci. 1999.04; 19 (7): 2580-2588. ( PubMed )

  125. Yamada K, Watanabe M, Shibata T, Nagashima M, Tanaka K, Inoue Y. Glutamate transporter GLT-1 is transiently localized on growing axons of the mouse spinal cord before establishing astrocytic expression. J Neurosci. 1998.08; 18 (15): 5706-5713. ( PubMed )

  126. Harada T, Harada C, Watanabe M, Inoue Y, Sakagawa T, Nakayama N, Sasaki S, Okuyama S, Watase K, Wada K, Tanaka K. Functions of the two glutamate transporters GLAST and GLT-1 in the retina. Proc Natl Acad Sci USA. 1998.04; 95 (8): 4663-4666. ( PubMed )

  127. Watase K, Hashimoto K, Kano M, Yamada K, Watanabe M, Inoue Y, Okuyama S, Sakagawa T, Ogawa S, Kawashima N, Hori S, Takimoto M, Wada K, Tanaka K. Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice. Eur J Neurosci. 1998.03; 10 (3): 976-988. ( PubMed )

  128. Nonaka M, Kohmura E, Yamashita T, Shimada S, Tanaka K, Yoshimine T, Tohyama M, Hayakawa T. Increased transcription of glutamate-aspartate transporter (GLAST/GluT-1) mRNA following kainic acid-induced limbic seizure. Brain Res Mol Brain Res. 1998.03; 55 (1): 54-60. ( PubMed )

  129. Yamashita H, Kawakami H, Zhang YX, Tanaka K, Nakamura S. Effect of amino acid ergot alkaloids on glutamate transport via human glutamate transporter hGluT-1. J Neurol Sci. 1998.02; 155 (1): 31-36. ( PubMed )

  130. Hirano, T., Morimoto, K., Yamamoto, Y., Sato, H., Watanabe, T., Sato, K., Sato, S., Yamada, N., Tanaka, K. and Suwaki, H.. Time-dependent and regional expression of GABA transporter mRNAs following amygdala-kindled seizures in rats. Mol Brain Res. 1998; 54 49-55.

  131. Shibata T, Yamada K, Watanabe M, Ikenaka K, Wada K, Tanaka K, Inoue Y. Glutamate transporter GLAST is expressed in the radial glia-astrocyte lineage of developing mouse spinal cord. J Neurosci. 1997.12; 17 (23): 9212-9219. ( PubMed )

  132. Itoh M, Watanabe Y, Watanabe M, Tanaka K, Wada K, Takashima S. Expression of a glutamate transporter subtype, EAAT4, in the developing human cerebellum. Brain Res. 1997.09; 767 (2): 265-271. ( PubMed )

  133. Maeno-Hikichi Y, Tanaka K, Shibata T, Watanabe M, Inoue Y, Mukainaka Y, Wada K. Structure and functional expression of the cloned mouse neuronal high-affinity glutamate transporter. Brain Res Mol Brain Res. 1997.08; 48 (1): 176-180. ( PubMed )

  134. Suh JG, Ichihara N, Saigoh K, Nakabayashi O, Yamanishi T, Tanaka K, Wada K, Kikuchi T. An in-frame deletion in peripheral myelin protein-22 gene causes hypomyelination and cell death of the Schwann cells in the new Trembler mutant mice. Neuroscience. 1997.08; 79 (3): 735-744. ( PubMed )

  135. Tanaka J, Ichikawa R, Watanabe M, Tanaka K, Inoue Y. Extra-junctional localization of glutamate transporter EAAT4 at excitatory Purkinje cell synapses. Neuroreport. 1997.07; 8 (11): 2461-2464. ( PubMed )

  136. Tanaka K, Watase K, Manabe T, Yamada K, Watanabe M, Takahashi K, Iwama H, Nishikawa T, Ichihara N, Kikuchi T, Okuyama S, Kawashima N, Hori S, Takimoto M, Wada K. Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science. 1997.06; 276 (5319): 1699-1702. ( PubMed )

  137. Suh JG, Takai S, Yamanishi T, Kikuchi T, Folz RJ, Tanaka K, Oh YS, Wada K. Sequence analysis, tissue expression and chromosomal localization of a mouse secreted superoxide dismutase gene. Mol Cells. 1997.04; 7 (2): 204-207. ( PubMed )

  138. Yamada K, Wada S, Watanabe M, Tanaka K, Wada K, Inoue Y. Changes in expression and distribution of the glutamate transporter EAAT4 in developing mouse Purkinje cells. Neurosci Res. 1997.03; 27 (3): 191-198. ( PubMed )

  139. Yamada K, Watanabe M, Shibata T, Tanaka K, Wada K, Inoue Y. EAAT4 is a post-synaptic glutamate transporter at Purkinje cell synapses. Neuroreport. 1996.08; 7 (12): 2013-2017. ( PubMed )

  140. Maeno H, Yoshimura R, Fujita S, Su Q, Tanaka K, Wada K, Kiyama H. Cloning and characterization of the rat neurotensin receptor gene promoter. Brain Res Mol Brain Res. 1996.08; 40 (1): 97-104. ( PubMed )

  141. Yamashita T, Kohmura E, Yuguchi T, Shimada S, Tanaka K, Hayakawa T, Tohyama M. Changes in glutamate/aspartate transporter (GLAST/GluT-1) mRNA expression following facial nerve transection. Brain Res Mol Brain Res. 1996.06; 38 (2): 294-299. ( PubMed )

  142. Hagiwara T, Tanaka K, Takai S, Maeno-Hikichi Y, Mukainaka Y, Wada K. Genomic organization, promoter analysis, and chromosomal localization of the gene for the mouse glial high-affinity glutamate transporter Slc1a3. Genomics. 1996.05; 33 (3): 508-515. ( PubMed, DOI )

  143. Nakayama T, Kawakami H, Tanaka K, Nakamura S. Expression of three glutamate transporter subtype mRNAs in human brain regions and peripheral tissues. Brain Res Mol Brain Res. 1996.02; 36 (1): 189-192. ( PubMed )

  144. Shibata T, Watanabe M, Tanaka K, Wada K, Inoue Y. Dynamic changes in expression of glutamate transporter mRNAs in developing brain. Neuroreport. 1996.02; 7 (3): 705-709. ( PubMed )

  145. Yamashita H, Kawakami H, Zhang YX, Tanaka K, Nakamura S. Neuroprotective mechanism of bromocriptine. Lancet. 1995.11; 346 (8985): 1305. ( PubMed )

  146. Suh JG, Yamanishi T, Matsui K, Tanaka K, Wada K. Mapping of the gracile axonal dystrophy (gad) gene to a region between D5Mit197 and D5Mit113 on proximal mouse chromosome 5. Genomics. 1995.06; 27 (3): 549-551. ( PubMed, DOI )

  147. Mukainaka Y, Tanaka K, Hagiwara T, Wada K. Molecular cloning of two glutamate transporter subtypes from mouse brain. Biochim Biophys Acta. 1995.05; 1244 (1): 233-237. ( PubMed )

  148. Yamashita H, Kawakami H, Zhang YX, Hagiwara T, Tanaka K, Nakamura S. Inhibition by folded isomers of L-2-(carboxycyclopropyl)glycine of glutamate uptake via the human glutamate transporter hGluT-1. Eur J Pharmacol. 1995.04; 289 (2): 387-390. ( PubMed )

  149. Takai S, Yamada K, Kawakami H, Tanaka K, Nakamura S. Localization of the gene (SLC1A3) encoding human glutamate transporter (GluT-1) to 5p13 by fluorescence in situ hybridization. Cytogenet Cell Genet. 1995; 69 (3-4): 209-210. ( PubMed )

  150. Otori Y, Shimada S, Tanaka K, Ishimoto I, Tano Y, Tohyama M. Marked increase in glutamate-aspartate transporter (GLAST/GluT-1) mRNA following transient retinal ischemia. Brain Res Mol Brain Res. 1994.12; 27 (2): 310-314. ( PubMed )

  151. Kawakami H, Tanaka K, Nakayama T, Inoue K, Nakamura S. Cloning and expression of a human glutamate transporter. Biochem Biophys Res Commun. 1994.02; 199 (1): 171-176. ( PubMed, DOI )

  152. Tanaka K. Pharmacological characterization of a cloned rat glutamate transporter (GluT-1). Brain Res Mol Brain Res. 1994.01; 21 (1-2): 167-170. ( PubMed )

  153. Suh, J. G., Oda, K., Tanaka, K., Yorifuji, H., Tomita, T. and Wada, K. . Pathophysiological study of axonal degeneration in the Gracile Axonal Dystrophy (gad) mutant mice. Biomed Res. 1994; 15 241-246.

  154. Tanaka K. Cloning and expression of a glutamate transporter from mouse brain. Neurosci Lett. 1993.09; 159 (1-2): 183-186. ( PubMed )

  155. Tanaka K. Expression cloning of a rat glutamate transporter. Neurosci Res. 1993.02; 16 (2): 149-153. ( PubMed )

  156. Koyano K, Tanaka K, Kuba K. A patch-clamp study on the muscarine-sensitive potassium channel in bullfrog sympathetic ganglion cells. J Physiol (Lond). 1992.08; 454 231-246. ( PubMed )

  157. Tanaka K, Koyano K, Kuba K. A muscarine-activated voltage-independent K+ channel in cultured bullfrog sympathetic neurones. Neurosci Lett. 1991.01; 121 (1-2): 191-193. ( PubMed )

  158. Tanaka K, Masu M, Nakanishi S. Structure and functional expression of the cloned rat neurotensin receptor. Neuron. 1990.06; 4 (6): 847-854. ( PubMed )

  159. Yokota Y, Sasai Y, Tanaka K, Fujiwara T, Tsuchida K, Shigemoto R, Kakizuka A, Ohkubo H, Nakanishi S. Molecular characterization of a functional cDNA for rat substance P receptor. J Biol Chem. 1989.10; 264 (30): 17649-17652. ( PubMed )

  160. Tanaka K, Kuba K. The Ca2+-sensitive K+-currents underlying the slow afterhyperpolarization of bullfrog sympathetic neurones. Pflugers Arch. 1987.10; 410 (3): 234-242. ( PubMed )

  161. Tanaka K, Minota S, Kuba K, Koyano K, Abe T. Differential effects of apamin on Ca2+-dependent K+ currents in bullfrog sympathetic ganglion cells. Neurosci Lett. 1986.09; 69 (3): 233-238. ( PubMed )

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講演・口頭発表等 【 表示 / 非表示

  1. Ishida Saeko, Ogawa Hiroshi, Tanaka Kohichi. Glutamateinduced excitotoxicity in midbrain and cerebellum. Experimental Animals 2018.07.01

  2. Ishida Saeko, Ogawa Hiroshi, Tanaka Kohichi. 中脳および小脳におけるグルタミン酸誘発性の興奮毒性(Glutamateinduced excitotoxicity in midbrain and cerebellum). Experimental Animals 2018.07.01

  3. Ishida Saeko, Ogawa Hiroshi, Tanaka Kohichi. 中脳および小脳におけるグルタミン酸誘発性の興奮毒性(Glutamateinduced excitotoxicity in midbrain and cerebellum). Experimental Animals 2018.07.01

  4. Ishida Saeko, Ogawa Hiroshi, Tanaka Kohichi. 中脳および小脳におけるグルタミン酸誘発性の興奮毒性(Glutamateinduced excitotoxicity in midbrain and cerebellum). Experimental Animals 2018.07.01

  5. Uchida Mizuki, Hida Hirotake, Mori Kentaro, Kitagaki Shinji, Ozaki Norio, Tanaka Kohichi, Yoshimi Akira, Noda Yukihiro. Functional roles of glial glutamate transporter in psychobehavioral abnormalities of mice administered phencyclidine repeatedly. Journal of Pharmacological Sciences 2017.03.01

  6. 田中 光一. 神経発達とその異常におけるグルタミン酸の役割. 脳と発達 2022.05.01

  7. 野田 幸裕, 内田 美月, 長谷川 章, 北垣 伸治, 尾崎 紀夫, 田中 光一. 認知機能におけるグルタミン酸トランスポーター(GLAST)の役割. 日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集 2017.09.01

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特許 【 表示 / 非表示

  • 遺伝子ノックイン細胞の作製方法

    特許番号: 特許第6958917号

  • 簡便で高効率の遺伝子改変非ヒト哺乳動物の作製方法

    特許番号: 特許第6888213号

  • 簡便で高効率の遺伝子改変非ヒト哺乳動物の作製方法

    特許番号: 6190995

  • グルタミン酸トランスポーターGLAST機能欠損マウス

    特許番号: 特許第449430号

受賞学術賞 【 表示 / 非表示

  • JUN and MARY Wada奨励賞,1998年

その他業績 【 表示 / 非表示

  • 2020年09月

    AAAS EurekAlert! The Global Souce for Science News

  • 「片頭痛の前兆に関与する遺伝子をマウスで発見」 ―片頭痛の病態解明や新たな治療薬の開発に前進―,2020年06月

    GLIA

  • 「 グリア細胞の異常が引き起こす慢性疼痛の仕組みを解明 」 慢性疼痛に対する新規治療法の開発へ前進 ―,2018年05月

    Glia

  • 「てんかん発作の多様性を引き起こす仕組みをマウスで発見」 てんかんの病態解明や新たな治療薬の開発に拍車 ―,2017年12月

    Glia

  • 「筋萎縮性側索硬化症に似た症状をグリア細胞の異常が引き起こす機序を解明」 筋萎縮性側索硬化症の治療薬の開発に拍車 ―,2017年08月

    Journal of Neuroscience

  • 「筋萎縮性側索硬化症に似た症状をグリア細胞の異常が引き起こす機序を解明」― 筋萎縮性側索硬化症の治療薬の開発に拍車 ―,2017年08月

    Journal of Neuroscience

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担当授業科目(学内) 【 表示 / 非表示

  • 神経科学