Published Papers & Misc - TANAKA Shinji

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  1. Shimada S, Tanaka S. The chronicles of hepatocellular carcinoma classification: Subtyping, modeling, and treatment. Hepatology. 2024.02; 79 (2): 261-263. ( PubMed, DOI )

  2. Tsukihara S, Akiyama Y, Shimada S, Hatano M, Igarashi Y, Taniai T, Tanji Y, Kodera K, Yasukawa K, Umeura K, Kamachi A, Nara A, Okuno K, Tokunaga M, Katoh H, Ishikawa S, Ikegami T, Kinugasa Y, Eto K, Tanaka S. Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer. Oncogene. 2025.03; 44 (11): 724-738. ( PubMed, DOI )

  3. Igarashi Y, Akiyama Y, Shimada S, Watanabe S, Hatano M, Kodera K, Okazaki K, Tanji Y, Tsukihara S, Taniai T, Nara A, Yamane M, Kamachi A, Umemura K, Yasukawa K, Ono H, Akahoshi K, Tanabe M, Haruki K, Furukawa K, Ikegami T, Tanaka S. Identification and clinical implications of endogenous retrovirus elements suppressed by SETDB1 in hepatocellular carcinoma. JHEP Reports. 2025.03; 7 (3): 101307. ( DOI )

  4. Taniai T, Shimada S, Akiyama Y, Hatano M, Yasukawa K, Igarashi Y, Tsukihara S, Tanji Y, Kodera K, Okazaki K, Haruki K, Nara A, Yagi K, Akahoshi K, Ban D, Asahina Y, Ikegami T, Tanabe M, Tanaka S. Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular hepatocellular carcinoma. Hepatology. 2024; 83 (2): 231-in press.

  5. Yasukawa K, Shimada S, Akiyama Y, Taniai T, Igarashi Y, Tsukihara S, Tanji Y, Umemura K, Kamachi A, Nara A, Yamane M, Akahoshi K, Shimizu A, Soejima Y, Tanabe M, Tanaka S. ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma. Cell Reports Medicine. 2025.04; 6 (4): 102038. ( PubMed, DOI )

  6. Tanji Y, Shimada S, Kato M, Akiyama Y, Hatano M, Tsukihara S, Igarashi Y, Kodera K, Okazaki K, Yasukawa K, Umemura K, Kamachi A, Nara A, Yamane M, Ishikawa Y, Mochizuki E, Mochida Y, Ikegami T, Ban D, Uchida S, Tanaka S. Cytokine mRNA-based therapy alleviates dendritic cell and T cell paucity to eliminate aggressive pancreatic cancer in preclinical mouse models EBioMedicine. 2026; in press. ( PubMed, DOI )

  7. Atsushi Nara, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano, Yusuke Chino, Suguru Miyazawa, Hanako Tamura, Daisuke Asano, Yoshiya Ishikawa, Hiroki Ueda, Shuichi Watanabe, Eriko Katsuta, Keiichi Akahoshi, Kenichi Ohashi, Minoru Tanabe, Daisuke Ban, Shinji Tanaka. Targeting SPP1-CD44-Hedgehog Axis Elicits Therapeutic Effects in Hepatocellular Carcinoma by Suppressing Intratumoral Fibrosis. Cancer Sci. 2025.12; Online ahead of print. ( PubMed, DOI )

  8. Akahoshi K, Kaneko S, Tanaka S, Tanabe M, Ban D. Current status of multidisciplinary treatment strategies for hepatocellular carcinoma in the era of advanced systemic therapy Annals of Gastroenterological Surgery. 2025.12; 10 (2): 325-335.

  9. Kawai-Kitahata F, Asahina Y, Kakinuma S, Inada K, Mochida T, Watakabe K, Nobusawa T, Shimizu T, Tsuchiya J, Miyoshi M, Kaneko S, Murakawa M, Nitta S, Nakagawa M, Kinowaki Y, Ban D, Tanaka S, Anzai T, Takano S, Maekawa S, Enomoto N, Okamoto R. Genetic alterations in hepatocellular carcinoma after sustained virological response in relation to the molecular characterization of metabolic diseases. Hepatology Research. 2025.08; 55 (8): 1193-1203. ( PubMed, DOI )

  10. Yamane Masahiro, Ishikawa Yoshiya, Yamashita Hironari, Morimoto Koichiro, Asano Daisuke, Sugawara Toshitaka, Watanabe Shuichi, Ueda Hiroki, Akahoshi Keiichi, Ono Hiroaki, Tanaka Shinji, Tanabe Minoru. Middle segment preserving pancreatectomy versus total pancreatectomy: a comparative analysis of short- and long-term outcomes. Surgery Today. 2025.07; 55 (7): 930-940. ( ichushi )

  11. Ikeshima R, Takahashi H, Yamamoto H, Kouda S, Akisue R, Tsujimoto M, Yokoyama Y, Hirose H, Itakura H, Morimoto Y, Miyoshi N, Uemura M, Okuzaki D, Tanaka S, Eguchi H, Doki Y, Yamamoto H, Mori M. Enrichment of ornithine decarboxylase degron transduced colorectal cancer cells for extended application of cancer stem cell models. Scientific Reports. 2025.07; 15 (1): 22886. ( PubMed, DOI )

  12. Umemura K, Akiyama Y, Shimada S, Hatano M, Kono A, Yasukawa K, Kamachi A, Igarashi Y, Tsukihara S, Tanji Y, Morimoto K, Nara A, Yamane M, Akahoshi K, Ono H, Shimizu A, Soejima Y, Tanabe M, Ban D, Tanaka S. PAD2-mediated histone citrullination drives tumor progression by enhancing cell proliferation and modifying the microenvironment in pancreatic cancer Molecular Cancer Research. 2025.06; ( PubMed, DOI )

  13. Taniai, T; Shimada, S; Akiyama, Y; Hatano, M; Yasukawa, K; Igarashi, Y; Tsukihara, S; Tanji, Y; Kodera, K; Okazaki, K; Haruki, K; Nara, A; Yagi, K; Akahoshi, K; Ban, DSK; Asahina, Y; Ikegami, T; Tanabe, M; Tanaka, S. Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular HCC HEPATOLOGY. 2025.02; ( PubMed, DOI )

  14. Yamane M, Ishikawa Y, Yamashita H, Morimoto K, Asano D, Sugawara T, Watanabe S, Ueda H, Akahoshi K, Ono H, Tanaka S, Tanabe M. Middle segment preserving pancreatectomy versus total pancreatectomy: a comparative analysis of short- and long-term outcomes. Surgery Today. 2024.12; Online ahead of print.

  15. Hatano M, Akiyama Y, Shimada S, Yagi K, Akahoshi K, Itoh M, Tanabe M, Ogawa Y, Tanaka S. Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease-related hepatocellular carcinoma. Hepatology Communications. 2023.10; 7 (10): e0277.

  16. Hatano, M; Akiyama, Y; Shimada, S; Yagi, K; Akahoshi, K; Itoh, M; Tanabe, M; Ogawa, Y; Tanaka, S. Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease-related HCC HEPATOLOGY COMMUNICATIONS. 2023.10; 7 (10): ( PubMed, DOI )

  17. Yamane M, Ishikawa Y, Asano D, Watanabe S, Ueda H, Akahoshi K, Ono H, Kudo A, Tanaka S, Sugiyama Y, Muro S, Akita K, Tanabe M. Surgical anatomy of the dorsal pancreatic artery: Considering embryonic development. Pancreatology. 2023.09; 23 (6): 697-703. ( PubMed, DOI )

  18. Murota Y, Nagane M, Wu M, Santra M, Venkateswaran S, Tanaka S, Bradley N, Taga T, Tabu K. A niche-mimicking polymer hydrogel-based approach to identify molecular targets for tackling human pancreatic cancer stem cells. Inflammation and Regeneration. 2023.09; 43 (1): 46. ( PubMed, DOI )

  19. Morimoto K, Ueda H, Asano D, Ishikawa Y, Watanabe S, Akahoshi K, Ono H, Kobayashi M, Okamoto R, Tanaka S, Tanabe M. Incidence and Mechanism of Refractory Postoperative Cholangitis After Hepatectomy with Hepaticojejunostomy. Journal of Gastrointestinal Surgery. 2023.06; 27 (8): 1668-1676.

  20. Yagi K, Shimada S, Akiyama Y, Hatano M, Asano D, Ishikawa Y, Ueda H, Watanabe S, Akahoshi K, Ono H, Tanabe M, Tanaka S. Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in non-viral hepatocellular carcinoma. Sci Rep. 2023.06; 13 (1): 9449. ( PubMed, DOI )

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