Published Papers & Misc - SEKIYA Ichiro

1. Yoshimi Sugahara, Mitsuru Mizuno, Noe Miyashita, Hisako Katano, Ichiro Sekiya. Operator stress factors and cell contamination risks in cell processing facilities: An online survey-based analysis. Regen Ther. 2025.06; 29 397-403. ( PubMed, DOI )

2. Sekiya Ichiro. Meniscus Repair Using Synovial Stem Cells Regenerative Medicine in Sports and Orthopaedics. 2025.05; 351-362.

3. Ichiro Sekiya, Hisako Katano, Mitsuru Mizuno, Kentaro Endo, Asuka Asami, Michiko Kajiwara, Naoki Otomo, Hideyuki Koga, Jun Masumoto, Nobutake Ozeki. 3D-MRI analysis of cartilage thickness changes after PRP injection in medial knee osteoarthritis: A preliminary report. PLoS One. 2025.04; 20 (4): e0321067. ( PubMed, DOI )

4. Mitsuru Mizuno, Saeri Kimbara, Hanae Ichise, Natsumi Ishikawa, Yuto Nishihara, Miwako Nishio, Ichiro Sekiya. Cleaning methods for biosafety cabinet to eliminate residual mycoplasmas, viruses, and endotoxins after changeover. Regen Ther. 2025.03; 28 73-80. ( PubMed, DOI )

5. Riko Yamashita, Iori Nozawa, Shoichi Hasegawa, Yusuke Nakagawa, Kazumasa Miyatake, Hiroki Katagiri, Tomomasa Nakamura, Hideyuki Koga, Ichiro Sekiya, Toshitaka Yoshii, Kunikazu Tsuji. C-type natriuretic peptide suppresses VEGFa gene expression by attenuating IL6-STAT3 signal pathway in primary synovial fibroblasts from rat knee. Biochem Biophys Res Commun. 2025.02; 749 151290. ( PubMed, DOI )

6. Mitsuru Mizuno, Daisuke Suda, Chima Matsumura, Ichiro Sekiya. Changeover method for biosafety cabinets using ozone gas. PLoS One. 2025.01; 20 (1): e0318006. ( PubMed, DOI )

7. Yusuke Fuchioka, Kentaro Endo, Yuriko Sakamaki, Takahiro Tanimoto, Nobutake Ozeki, Yusuke Nakagawa, Hideyuki Koga, Makoto Tomita, Ichiro Sekiya. Scanning electron microscopy analysis of synovial and adipose mesenchymal stem cells adhering to cartilage. Regen Ther. 2024.12; 27 488-495. ( PubMed, DOI )

8. Hayato Kodama, Kentaro Endo, Ichiro Sekiya. Macrophage depletion in inflamed rat knees prevents the activation of synovial mesenchymal stem cells by weakening Nampt and Spp1 signaling. Inflamm Regen. 2024.11; 44 (1): 47. ( PubMed, DOI )

9. Yusuke Aimono, Kentaro Endo, Ichiro Sekiya. Cellular senescence contributes to spontaneous repair of the rat meniscus. Aging Cell. 2024.10; e14385. ( PubMed, DOI )

10. Hisako Katano, Nobutake Ozeki, Mitsuru Mizuno, Kentaro Endo, Hideyuki Koga, Jun Masumoto, Ichiro Sekiya. Femoral cartilage defects initiate from medial meniscus extrusion or tibial cartilage lesions and expand in knee osteoarthritis as revealed by 3D MRI analysis. Sci Rep. 2024.10; 14 (1): 25937. ( PubMed, DOI )

11. Tagawa Y, Saito T, Iwai H, Sato M, Noda S, Yamamoto A, Ota M, Endo K, Koga H, Takahara Y, Sugimoto K, Sekiya I, Fujio K, Kawakami E, Mizoguchi F, Yasuda S. ARID5B is a negative modulator of IL-6 production in rheumatoid arthritis synovial fibroblasts. Immunological medicine. 2024.09; 47 (3): 176-185. ( PubMed, DOI )

12. Naoko Araya, Hideyuki Koga, Yusuke Nakagawa, Mikio Shioda, Nobutake Ozeki, Yuji Kohno, Tomomasa Nakamura, Ichiro Sekiya, Hiroki Katagiri. Risk factors for delayed bone union in opening wedge high tibial osteotomy. Jt Dis Relat Surg. 2024.08; 35 (3): 546-553. ( PubMed, DOI )

13. Seiya Matsuta, Kentaro Endo, Nobutake Ozeki, Yusuke Nakagawa, Hideyuki Koga, Ichiro Sekiya. Synovial mesenchymal stem cells secrete more lubricin than adipose mesenchymal stem cells after injection into rat osteoarthritis knees. Biochem Biophys Res Commun. 2024.07; 729 150354. ( PubMed, DOI )

14. Nobutake Ozeki, Hideyuki Koga, Tomomasa Nakamura, Hiroki Katagiri, Yusuke Nakagawa, Takashi Hoshino, Mai Katakura, Masaki Amemiya, Aritoshi Yoshihara, Hisako Katano, Mitsuru Mizuno, Kentaro Endo, Jun Masumoto, Ichiro Sekiya. Cartilage thickness in the medial compartment of the knee joint evaluated by MRI three-dimensional analysis correlates with weight-bearing line ratio and joint line convergence angle. J Orthop Sci. 2024.07; ( PubMed, DOI )

15. Tetsuya Tachibana, Hiroki Katagiri, Junpei Matsuda, Nobutake Ozeki, Toshifumi Watanabe, Ichiro Sekiya, Tetsuya Jinno. Biomechanical analysis of load distribution in porcine hip joints at different acetabular coverages. BMC Musculoskelet Disord. 2024.07; 25 (1): 576. ( PubMed, DOI )

16. Hasegawa, S; Yamashita, R; Nakagawa, Y; Miyatake, K; Katagiri, H; Nakamura, T; Koga, H; Sekiya, I; Yoshii, T; Rosen, V; Tsuji, K. A novel methodology utilizing microchip implants to monitor individual activity and body temperature for assessing knee pain in group-housed rats SCIENTIFIC REPORTS. 2024.07; 14 (1): 16909. ( PubMed, DOI )

17. Nakagawa Y, Koga H, Sekiya I, Hasegawa S, Katagiri H, Watanabe T. Equivalent clinical outcomes between anatomical alignment versus mechanical alignment of simultaneous bilateral total knee arthroplasty using a posterior-stabilized prosthesis during an average follow-up of five years: a prospective randomized clinical trial. The Journal of arthroplasty. 2024.07; ( PubMed, DOI )

18. Nobutake Ozeki, Hideyuki Koga, Tomomasa Nakamura, Hiroki Katagiri, Yusuke Nakagawa, Takashi Hoshino, Mai Katakura, Masaki Amemiya, Aritoshi Yoshihara, Hisako Katano, Mitsuru Mizuno, Kentaro Endo, Jun Masumoto, Ichiro Sekiya. The association of the medial meniscus covering ratio with knee cartilage thickness at 15 medial compartment subregions as found by three-dimensional analysis using MRI. J Exp Orthop. 2024.07; 11 (3): e70005. ( PubMed, DOI )

19. Ryu Yoshida, Hideyuki Koga, Junpei Matsuda, Tomomasa Nakamura, Kazumasa Miyatake, Hiroki Katagiri, Mai Katakura, Aritoshi Yoshihara, Ryota Seki, Toyohiro Katsumata, Mitsuru Mizuno, Ken Watanabe, Ichiro Sekiya, Kunikazu Tsuji, Yusuke Nakagawa. Presoaking grafts in vancomycin does not impair graft-bone healing in a rat anterior cruciate ligament reconstruction model. Am J Sports Med. 2024.06; 52 (7): 1784-1793. ( PubMed, DOI )

20. Hiroki Katagiri, Yusuke Nakagawa, Toshiyuki Ohara, Tomomasa Nakamura, Aritoshi Yoshihara, Masaya Hayashi, Hideya Yoshimura, Tsuyoshi Nagase, Ichiro Sekiya, Hideyuki Koga. Serial assessment of factors associated with patient-reported outcomes up to 2 years after ACL reconstruction using autologous hamstring tendon: results from the TMDU MAKS study. Orthop J Sports Med. 2024.06; 12 (6): 23259671241254105. ( PubMed, DOI )

21. Mitsuru Mizuno, Kouichirou Yori, Toshikazu Takeuchi, Takaaki Yamamoto, Natsumi Ishikawa, Megumi Kobayashi, Miwako Nishio, Ichiro Sekiya. Evaluation of cleaning methods for change-over after the processing of cell products to avoid cross-contamination risk. Regen Ther. 2024.06; 26 489-495. ( PubMed, DOI )

22. Mitsuru Mizuno, Koki Abe, Takashi Kakimoto, Hisashi Hasebe, Ichiro Sekiya. Decreasing electricity costs of clean room for cell products during non-operation. Regen Ther. 2024.06; 26 1117-1123. ( PubMed, DOI )

23. Hisako Katano, Kanto Nagai, Haruka Kaneko, Eiji Sasaki, Naofumi Hashiguchi, Ryosuke Kuroda, Muneaki Ishijima, Yasuyuki Ishibashi, Nobuo Adachi, Makoto Tomita, Jun Masumoto, Ichiro Sekiya. Variations in knee cartilage thickness: Fully automatic three-dimensional analysis of MRIs from five manufacturers. Eur J Radiol. 2024.05; 176 111528. ( PubMed, DOI )

24. Mitsuru Mizuno, Koki Abe, Takashi Kakimoto, Hisashi Hasebe, Naoki Kagi, Ichiro Sekiya. Operator-derived particles and falling bacteria in biosafety cabinets. Regenarative Therapy. 2024.03; 25 264-272. ( PubMed, DOI, ichushi )

25. Mitsuru Mizuno, Yoshitaka Maeda, Sho Sanami, Takahisa Matsuzaki, Hiroshi Y Yoshikawa, Nobutake Ozeki, Hideyuki Koga, Ichiro Sekiya. Noninvasive total counting of cultured cells using a home-use scanner with a pattern sheet. iScience. 2024.03; 27 (3): 109170. ( PubMed, DOI )

26. Yugo Miura, Kentaro Endo, Ichiro Sekiya. Histological and biochemical changes in a rat rotator cuff tear model with or without the subacromial bursa. Tissue Cell. 2024.03; 88 102370. ( PubMed, DOI )

27. Nobutake Ozeki, Hideyuki Koga, Tomomasa Nakamura, Yusuke Nakagawa, Takashi Hoshino, Masaki Amemiya, Ichiro Sekiya. Real-time virtual sonography-guided ossicle removal in unresolved Osgood-Schlatter disease Arthroscopy Techniques. 2024.01; ( DOI )

28. Yang Yang, Hideyuki Koga, Yusuke Nakagawa, Tomomasa Nakamura, Hiroki Katagiri, Ryohei Takada, Mai Katakura, Kunikazu Tsuji, Ichiro Sekiya, Kazumasa Miyatake. Characteristics of the synovial microenvironment and synovial mesenchymal stem cells with hip osteoarthritis of different bone morphologies. Arthritis Res Ther. 2024.01; 26 (1): 17. ( PubMed, DOI )

29. Ozeki Nobutake, Nakamura Tomomasa, Nakagawa Yusuke, Sekiya Ichiro, Koga Hideyuki. Meniscus repair and centralization: Preserving meniscus function Journal of Joint Surgery and Research. 2023.12; 1 (1): 46-55. ( DOI ichushi )

30. Mitsuru Mizuno, Koki Abe, Takashi Kakimoto, Keiichi Yano, Yukiko Ota, Kengo Tomita, Naoki Kagi, Ichiro Sekiya. Volatile organic compounds and ionic substances contamination in cell processing facilities during rest period; a preliminary assessment of exposure to cell processing operators. Regenerative Therapy. 2023.12; 24 211-218. ( PubMed, DOI, ichushi )

31. Yusuke Nakagawa, Hideyuki Koga, Tomomasa Nakamura, Masafumi Horie, Hiroki Katagiri, Nobutake Ozeki, Toshiyuki Ohara, Ichiro Sekiya, Takeshi Muneta, Toshifumi Watanabe. Mid-term clinical outcomes of a posterior stabilized total knee prosthesis for Japanese patients: A minimum follow-up of 5 years. J Orthop Sci. 2023.11; ( PubMed, DOI, ichushi )

32. Ichiro Sekiya, Hisako Katano, Ali Guermazi, Yugo Miura, Noriya Okanouchi, Makoto Tomita, Jun Masumoto, Yoshio Kitazume, Hideyuki Koga, Nobutake Ozeki. Association of AI-determined Kellgren-Lawrence grade with medial meniscus extrusion and cartilage thickness by AI-based 3D MRI analysis in early knee osteoarthritis. Sci Rep. 2023.11; 13 (1): 20093. ( PubMed, DOI )

33. Hisako Katano, Nobutake Ozeki, Mitsuru Mizuno, Kentaro Endo, Noriya Okanouchi, Jo Fujita, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya. Morphological analysis of three-dimensional MR images of patellofemoral joints in asymptomatic subjects. Sci Rep. 2023.10; 13 (1): 16750. ( PubMed, DOI )

34. Zhu Ling, Hailati Aini, Shuhei Kajikawa, Jumpei Shirakawa, Kunikazu Tsuji, Yoshinori Asou, Hideyuki Koga, Ichiro Sekiya, Akira Nifuji, Masaki Noda, Yoichi Ezura. Mutation Are Treatable by Alendronate. Pharmaceuticals (Basel). 2023.10; 16 (10): ( PubMed, DOI )

35. Hideto Furuoka, Kentaro Endo, Ichiro Sekiya. Mesenchymal stem cells in synovial fluid increase in number in response to synovitis and display more tissue-reparative phenotypes in osteoarthritis. Stem Cell Res Ther. 2023.09; 14 (1): 244. ( PubMed, DOI )

36. Shoichi Hasegawa, Yusuke Nakagawa, Aritoshi Yoshihara, Tomomasa Nakamura, Hiroki Katagiri, Masaya Hayashi, Hideya Yoshimura, Tsuyoshi Nagase, Ichiro Sekiya, Hideyuki Koga. Older Age, Poor Preoperative Quadriceps Muscle Strength, and Residual Pain as Risk Factors for Poor Quadriceps Muscle Strength Recovery at 1 Year After ACL Reconstruction: A TMDU MAKS Study of 402 Patients. Orthop J Sports Med. 2023.09; 11 (9): 23259671231194593. ( PubMed, DOI )

37. Katagiri H, Nakagawa Y, Amano Y, Shirakawa Y, Ozeki N, Nakamura T, Sekiya I, Koga H. Decision regret following opening wedge high tibial osteotomy: Older age as a risk factor. The Knee. 2023.06; 43 62-69. ( PubMed, DOI )

38. Hasegawa S, An JS, Hino J, Amano Y, Nakagawa Y, Miyatake K, Katagiri H, Nakamura T, Sekiya I, Koga H, Tsuji K. Therapeutic effect of C-type natriuretic peptide on persistent pain in a rat knee arthritis model. Journal of orthopaedic surgery (Hong Kong). 2023.05; 31 (2): 10225536231181708. ( PubMed, DOI )

39. Amano Y, Ozeki N, Matsuda J, Nakamura T, Nakagawa Y, Sekiya I, Koga H. Augmentation of a Nonanatomical Repair of a Medial Meniscus Posterior Root Tear With Centralization Using Three Knotless Anchors May Be Associated With Less Meniscal Extrusion and Better Compressive Load Distribution in Mid-Flexion Compared With Non-Anatomical Root Repair Alone in a Porcine Knee Model. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. 2023.05; 39 (12): 2487-2498. ( PubMed, DOI )

40. M Isono, H Koga, Y Nakagawa, T Nakamura, I Sekiya, H Katagiri. Inferior Healing Rate in Isolated Meniscal Repair than that in Meniscal Repair with Concomitant ACL Reconstruction Evaluated with MRI. Malays Orthop J. 2023.03; 17 (1): 61-69. ( PubMed, DOI )

41. Mizuno Mitsuru, Yori Kouichirou, Takeuchi Toshikazu, Yamaguchi Tetsuya, Watanabe Ken, Tomaru Yasuhiro, Shimizu Norio, Sekiya Ichiro. Cross-contamination risk and decontamination during changeover after cell-product processing. Regenerative Therapy. 2023.03; 22 30-38. ( ichushi )

42. Ozeki N, Mizuno M, Yanada S, Okada T, Kubota R, Kushida Y, Furuoka H, Endo K, Katano H, Nakamura K, Ohya S, Koga H, Sekiya I. Autologous Synovial Mesenchymal Stem Cell Transplantation Suppresses Inflammation Caused by Synovial Harvesting and Promotes Healing in a Micro Minipig Repaired Meniscus Model. Transplantation proceedings. 2023.03; 55 (2): 470-480. ( PubMed, DOI )

43. Mizuno Mitsuru, Matsuda Junpei, Watanabe Ken, Shimizu Norio, Sekiya Ichiro. バイオセーフティキャビネット内での細胞製品の切り替えを処理するための消毒剤と手による拭き取りの効果(Effect of disinfectants and manual wiping for processing the cell product changeover in a biosafety cabinet) Regenerative Therapy. 2023.03; 22 169-175. ( ichushi )

44. Shunichi Fujii, Kentaro Endo, Nobutake Ozeki, Yuriko Sakamaki, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Comparison of adhesion of thawed and cultured synovial mesenchymal stem cells to the porcine meniscus and the relevance of cell surface microspikes. BMC Mol Cell Biol. 2022.12; 23 (1): 53. ( PubMed, DOI )

45. Mitsuru Mizuno,Yori K, Takeuchi T, Yamaguchi T, Watanabe K, Tomaru Y, Shimizu N, Sekiya I. Cross-contamination risk and decontamination during changeover after cell-product processing Regenerative Therapy. 2022.12; 22 30-38. ( PubMed, DOI )

46. Fujii Shunichi, Endo Kentaro, Matsuta Seiya, Komori Keiichiro, Sekiya Ichiro. 膝蓋下脂肪体由来の脱分化型脂肪細胞と間葉系幹細胞の収量と特性の比較(Comparison of the yields and properties of dedifferentiated fat cells and mesenchymal stem cells derived from infrapatellar fat pads) Regenerative Therapy. 2022.12; 21 611-619. ( ichushi )

47. Mizuno Mitsuru, Sugahara Yoshimi, Iwayama Daisuke, Miyashita Noe, Katano Hisako, Sekiya Ichiro. 細胞加工オペレーターのストレスとモチベーション　オンライン質問票調査のパイロット試験(Stress and motivation of cell processing operators: A pilot study of an online questionnaire survey) Regenerative Therapy. 2022.12; 21 547-552. ( ichushi )

48. Mizuno Mitsuru, Ozeki Nobutake, Sekiya Ichiro. 変形性関節症に対する細胞療法でトリソミー7を有する培養細胞を使用する場合の安全性(Safety of using cultured cells with trisomy 7 in cell therapy for treating osteoarthritis) Regenerative Therapy. 2022.12; 21 81-86. ( ichushi )

49. Hideyuki Koga, Tomomasa Nakamura, Yusuke Nakagawa, Nobutake Ozeki, Takashi Hoshino, Masaki Amemiya, Ichiro Sekiya. Simultaneous Correction of Varus Deformity and Posterior Tibial Slope by Modified Hybrid Closed-Wedge High Tibial Osteotomy. Arthrosc Tech. 2022.11; 11 (11): e2081-e2089. ( PubMed, DOI )

50. Mitsuru Mizuno, Yoshimi Sugahara, Daisuke Iwayama, Noe Miyashita, Hisako Katano, Ichiro Sekiya. Stress and motivation of cell processing operators: A pilot study of an online questionnaire survey Regenerative Therapy. 2022.11; 21 547-552. ( PubMed, DOI )

51. Shunichi Fujii, Kentaro Endo, Seiya Matsuda, Keiichiro Komori,Ichiro Sekiya. Comparison of the yields and properties of dedifferentiated fat cells and mesenchymal stem cells derived from infrapatellar fat pads Regenerative Therapy. 2022.11; 21 611-619. ( PubMed, DOI )

52. Ichiro Sekiya, Nobutake Ozeki. The 16th International Workshop on Osteoarthritis Imaging:“New insightson treatment and imaging: A :couple that belongs together" Osteoarthritis Imaging. 2022.10; Volume 2 (Supplement 1):

53. Takahiro Tanimoto, Kentaro Endo, Yuriko Sakamaki, Nobutake Ozeki, Hisako Katano, Mitsuru Mizuno, Hideyuki Koga, Ichiro Sekiya . Human synovial mesenchymal stem cells show time-dependent morphological changes and increased adhesion to degenerated porcine cartilage. Scientific Reports. 2022.10; 12 (1): 16619. ( PubMed, DOI )

54. Masaaki Isono, Jun Takeuchi, Ami Maehara, Yusuke Nakagawa, Hiroki Katagiri, Kazumasa Miyatake, Ichiro Sekiya, Hideyuki Koga, Yoshinori Asou, Kunikazu Tsuji. Effect of CD44 signal axis in the gain of mesenchymal stem cell surface antigens from synovial fibroblasts in vitro Heliyon. 2022.10; 8 (10): e10739. ( PubMed, DOI )

55. Ichiro Sekiya, Sho Sasaki, Yugo Miura, Hayato Aoki, Hisako Katano, Noriya Okanouchi, Makoto Tomita, Jun Masumoto, Hideyuki Koga, Nobutake Ozeki. Medial Tibial Osteophyte Width Strongly Reflects Medial Meniscus Extrusion Distance and Medial Joint Space Width Moderately Reflects Cartilage Thickness in Knee Radiographs. J Magn Reson Imaging. 2022.09; 56 (3): 824-834. ( PubMed, DOI )

56. Seiji Noda, Tadashi Hosoya, Yoji Komiya, Yasuhiro Tagawa, Kentaro Endo, Keiichiro Komori, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya. CD34 + THY1 + synovial fibroblast subset in arthritic joints has high osteoblastic and chondrogenic potentials in vitro Arthritis Res Ther. 2022.09; 24 (1): 224. ( PubMed, DOI )

57. Hiroki Katagiri, Mikio Shioda, Yusuke Nakagawa, Toshiyuki Ohara, Nobutake Ozeki, Tomomasa Nakamura, Ichiro Sekiya, Hideyuki Koga. Risk Factors Affecting Return to Sports and Patient-Reported Outcomes After Opening-Wedge High Tibial Osteotomy in Active Patients. Orthop J Sports Med. 2022.09; 10 (9): 23259671221118836. ( PubMed, DOI )

58. Tsukasa Kitahashi, Ryo Kogawa, Kentaro Nakamura, Ichiro Sekiya. Integrin β1, PDGFRβ, and type II collagen are essential for meniscus regeneration by synovial mesenchymal stem cells in rats. Scientific Reports. 2022.08; 12 (1): 14148. ( PubMed, DOI )

59. Ichiro Sekiya, Hideyuki Koga, Hisako Katano, Mitsuru Mizuno, Yuji Kohno, Koji Otabe, Nobutake Ozeki. Second-look arthroscopy after meniscus repair and synovial mesenchymal stem cell transplantation to treat degenerative flaps and radial tears of the medial meniscus: A case report. J Orthop Sci. 2022.07; 27 (4): 821-834. ( PubMed, DOI )

60. Sekiya Ichiro, Koga Hideyuki, Katano Hisako, Mizuno Mitsuru, Kohno Yuji, Otabe Koji, Ozeki Nobutake. 半月板修復術と滑膜間葉幹細胞移植による内側半月板の変性フラップおよび橈骨断裂治療後のセカンドルック関節鏡検査　症例報告(Second-look arthroscopy after meniscus repair and synovial mesenchymal stem cell transplantation to treat degenerative flaps and radial tears of the medial meniscus: A case report) Journal of Orthopaedic Science. 2022.07; 27 (4): 821-834. ( ichushi )

61. Yugo Miura, Kentaro Endo, Keiichiro Komori, Ichiro Sekiya. Clearance of senescent cells with ABT-263 improves biological functions of synovial mesenchymal stem cells from osteoarthritis patients Stem Cell Research & Therapy. 2022.06; 3 (1): 222. ( PubMed, DOI )

62. Mituru Mizunoi,Nobutake Ozeki,Ichiro Sekiya. Safety of using cultured cells with trisomy 7 in cell therapy for treating osteoarthritis Regenerative Therapy. 2022.06; 17 (21): 81-86. ( PubMed, DOI )

63. Mituru Mizuno,Takahisa Matsuzaki,Nobutake Ozeki,Hisako Katano,Hideyuki Koga,Takanori Takebe,Hiroshi Yoshikawa,Ichiro Sekiya. Cell membrane fluidity and ROS resistance define DMSO tolerance of cryopreserved synovial MSCs and HUVECs. Stem Cell Research & Therapy. 2022.05; 13 (1): 177. ( PubMed, DOI )

64. Hirotaka Nakashima, Soshi Uchida, Akihisa Hatakeyama, Yoichi Murata, Yoshiaki Yamanaka, Manabu Tsukamoto, Ichiro Sekiya, Akinori Sakai. Isolation and Characterization of Synovial Mesenchymal Stem Cells Derived From Patients With Chronic Lateral Ankle Instability: A Comparative Analysis of Synovial Fluid, Adipose Synovium, and Fibrous Synovium of the Ankle Joint. Orthop J Sports Med. 2022.05; 10 (5): 23259671221094615. ( PubMed, DOI )

65. Guo Tang, Yoshinori Asou, Etsuko Matsumura, Yusuke Nakagawa, Kazumasa Miyatake, Hiroki Katagiri, Tomomasa Nakamura, Hideyuki Koga, Keiichiro Komori, Ichiro Sekiya, Yoich Ezura, Kunikazu Tsuji. Short cytoplasmic isoform of IL1R1/CD121a mediates IL1β induced proliferation of synovium-derived mesenchymal stem/stromal cells through ERK1/2 pathway. Heliyon. 2022.05; 8 (5): e09476. ( PubMed, DOI )

66. Yuji Kohno, Hideyuki Koga, Nobutake Ozeki, Junpei Matsuda, Mitsuru Mizuno, Hisako Katano, Ichiro Sekiya. Biomechanical analysis of a centralization procedure for extruded lateral meniscus after meniscectomy in porcine knee joints. Journal Orthopaedic Research. 2022.05; 40 (5): 1097-1103. ( PubMed, DOI )

67. Ozeki N, Koga H, Sekiya I. Degenerative meniscus in knee osteoarthritis: from pathology to treatment. life. 2022.04; 12 (4): 603. ( PubMed, DOI )

68. Ozeki N, Koga H, Nakamura T, Nakagawa Y, Ohara T, An JS, Sekiya I. Ultrasound-Assisted Arthroscopic All-Inside Repair Technique for Posterior Lateral Meniscus Tear. Arthroscopy techniques. 2022.04; 11 (5): e929-e935. ( PubMed, DOI )

69. Yuji Kohno, Mitsuru Mizuno, Kentaro Endo, Nobutake Ozeki, Hisako Katano, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Hideyuki Koga, Ichiro Sekiya. Yields of mesenchymal stromal cells from synovial fluid reflect those from synovium in patients with rheumatoid arthritis Tissue and Cell. 2022.04; 75 101727. ( PubMed, DOI )

70. Yugo Miura, Nobutake Ozeki, Hisako Katano, Hayato Aoki, Noriya Okanouchi, Makoto Tomita, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya. Difference in the joint space of the medial knee compartment between full extension and Rosenberg weight-bearing radiographs. Eur Radiol. 2022.03; 32 (3): 1429-1437. ( PubMed, DOI )

71. Hisako Katano, Nobutake Ozeki, Hideyuki Koga, Makoto Tomita, Kenji Suzuki, Jun Masumoto, Ichiro Sekiya. Three-dimensional MRI shows cartilage defect extension with no separation from the meniscus in women in their 70s with knee osteoarthritis. Sci Rep.(Scientific Reports). 2022.03; 12 (1): 4198. ( PubMed, DOI )

72. Hisako Katano, Nobutake Ozeki, Hideyuki Koga, Kenji Suzuki, Jun Masumoto, Makoto Tomita, Ichiro Sekiya. Interscan measurement error in measurements of the meniscus, including the meniscal roots, by fully automatic three-dimensional MRI analysis. Osteoarthritis Imaging.. 2022.03; 2 (1): ( DOI )

73. Takashi Hoshino, Yusuke Nakagawa, Kei Inomata, Toshiyuki Ohara, Hiroki Katagiri, Koji Otabe, Kanehiro Hiyama, Kenta Katagiri, Mai Katakura, Hiroko Ueki, Masaya Hayashi, Tsuyoshi Nagase, Ichiro Sekiya, Takashi Ogiuchi, Takeshi Muneta, Hideyuki Koga. Effects of different surgical procedures for meniscus injury on two-year clinical and radiological outcomes after anterior cruciate ligament reconstructions. -TMDU MAKS study. J Orthop Sci. 2022.01; 27 (1): 199-206. ( PubMed, DOI )

74. Hoshino Takashi, Nakagawa Yusuke, Inomata Kei, Ohara Toshiyuki, Katagiri Hiroki, Otabe Koji, Hiyama Kanehiro, Katagiri Kenta, Katakura Mai, Ueki Hiroko, Hayashi Masaya, Nagase Tsuyoshi, Sekiya Ichiro, Ogiuchi Takashi, Muneta Takeshi, Koga Hideyuki, the Tokyo Medical and Dental University(TMDU) Multicenter Arthroscopic Knee Surgery(MAKS) Group. 半月板損傷に対する異なる術式が前十字靱帯修復後の2年臨床アウトカムとX線学的アウトカムに及ぼす影響　TMDU MAKS試験(Effects of different surgical procedures for meniscus injury on two-year clinical and radiological outcomes after anterior cruciate ligament reconstructions: TMDU MAKS study) Journal of Orthopaedic Science. 2022.01; 27 (1): 199-206. ( ichushi )

75. Katsuaki Yanagisawa, Toshifumi Watanabe, Hideyuki Koga, Ichiro Sekiya, Takeshi Muneta, Tetsuya Jinno. Do the distal femur and the proximal tibia have narrower aspect ratios in smaller knees? : A morphological analysis of osteoarthritic knees in the Japanese population using computed tomography. Knee. 2021.12; 33 84-92. ( PubMed, DOI )

76. Nobutake Ozeki, Hideyuki Koga, Tomomasa Nakamura, Yusuke Nakagawa, Toshiyuki Ohara, Yuji Kohno, Ichiro Sekiya. Surgical Repair of Symptomatic Wrisberg Variant Discoid Lateral Mensicus with Pull-Out Repair and Capsulodesis. Arthrosc Tech. 2021.12; 11 (1): e61-e68. ( PubMed, DOI )

77. Mitsuru Mizuno, Kentaro Endo, Hisako Katano, Naoki Amano, Masaki Nomura, Yoshinori Hasegawa, Nobutake Ozeki, Hideyuki Koga, Naoko Takasu, Osamu Ohara, Tomohiro Morio, Ichiro Sekiya. Transplantation of human autologous synovial mesenchymal stem cells with trisomy 7 into the knee joint and 5 years of follow-up. Stem Cells Transl Med. 2021.11; 10 (11): 1530-1543. ( PubMed, DOI )

78. Iwata H, Takada N, Kuroyanagi G, Ikuta K, Usami T, Sekiya I, Murakami H. Effect of hydroxyapatite tubes on the lag screw intraoperative insertion torque for the treatment of intertrochanteric femoral fractures. Injury. 2021.11; 52 (11): 3377-3381. ( PubMed, DOI )

79. Kentaro Endo, Kiyotaka Horiuchi, Hisako Katano, Nobutake Ozeki, Yuriko Sakamaki, Hideyuki Koga, Ichiro Sekiya. Intra-articular Injection of PDGF-BB Explored in a Novel in Vitro Model Mobilizes Mesenchymal Stem Cells From the Synovium Into Synovial Fluid in Rats. Stem Cell Rev Rep. 2021.10; 17 (5): 1768-1779. ( PubMed, DOI )

80. Hisako Katano, Nobutake Ozeki, Yuji Kohno, Yusuke Nakagawa, Hideyuki Koga, Toshifumi Watanabe, Tetsuya Jinno, Ichiro Sekiya. Trends in arthroplasty in Japan by a complete survey, 2014-2017. J Orthop Sci. 2021.09; 26 (5): 812-822. ( PubMed, DOI, ichushi )

81. Misaki Yagi, Mitsuru Mizuno, Ryota Fujisawa, Hisako Katano, Kentaro Endo, Nobutake Ozeki, Yuriko Sakamaki, Hideyuki Koga, Ichiro Sekiya. Optimal Pore Size of Honeycomb Polylactic Acid Films for In Vitro Cartilage Formation by Synovial Mesenchymal Stem Cells. Stem Cells Int. 2021.08; eCollection 2021:9239728. ( PubMed, DOI )

82. Takashi Hoshino, Toshifumi Watanabe, Yusuke Nakagawa, Hiroki Katagiri, Nobutake Ozeki, Toshiyuki Ohara, Mikio Shioda, Yuji Kono, Ichiro Sekiya, Hideyuki Koga. Clinical outcomes of two-stage revision total knee arthroplasty in infected cases with antibiotic-loaded cement spacers produced using a handmade silicone mold. Knee Surg Relat Res. 2021.08; 33 (1): 27. ( PubMed, DOI )

83. Toshifumi Watanabe, Kazuyoshi Gamada, Hideyuki Koga, Ichiro Sekiya, Takeshi Muneta, Tetsuya Jinno. Consistent femoral external rotation during weight-bearing knee flexion is associated with better patient-reported pain and mediolateral balance after total knee arthroplasty. Clin Biomech (Bristol, Avon). 2021.08; 88 105438. ( PubMed, DOI )

84. Hiroki Katagiri, Kaori Nakamura, Takeshi Muneta, Toshifumi Watanabe, Kazumasa Miyatake, Ichiro Sekiya, Hideyuki Koga, Kunikazu Tsuji. Inflammatory and healing environment in synovial fluid after anterior cruciate ligament reconstruction: Granulocytes and endogenous opioids as new targets of postoperative pain. Biochem Biophys Rep. 2021.07; 26 100981. ( PubMed, DOI )

85. Ichiro Sekiya, Hisako Katano, Mitsuru Mizuno, Hideyuki Koga, Jun Masumoto, Makoto Tomita, Nobutake Ozeki. Alterations in cartilage quantification before and after injections of mesenchymal stem cells into osteoarthritic knees. Sci Rep. 2021.07; 11 (1): 13832. ( PubMed, DOI )

86. Hiroko Ueki, Hiroki Katagiri, Kunikazu Tsuji, Kazumasa Miyatake, Toshifumi Watanabe, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Effect of transplanted mesenchymal stem cell number on the prevention of cartilage degeneration and pain reduction in a posttraumatic osteoarthritis rat model. J Orthop Sci. 2021.07; 26 (4): 690-697. ( PubMed, DOI )

87. Kazumasa Kawata, Hideyuki Koga, Kunikazu Tsuji, Kazumasa Miyatake, Yusuke Nakagawa, Takanori Yokota, Ichiro Sekiya, Hiroki Katagiri. Extracellular vesicles derived from mesenchymal stromal cells mediate endogenous cell growth and migration via the CXCL5 and CXCL6/CXCR2 axes and repair menisci. Stem Cell Res Ther. 2021.07; 12 (1): 414. ( PubMed, DOI )

88. Nobutake Ozeki, Yusuke Nakagawa, Mitsuru Mizuno, Yuji Kohno, Hisako Katano, Hideyuki Koga, Ichiro Sekiya. Ultrasound-Guided Harvesting of Synovium for Regenerative Medicine of Cartilage and Meniscus Using Synovial Mesenchymal Stem Cells. Arthrosc Tech. 2021.07; 10 (7): e1723-e1727. ( PubMed, DOI )

89. Ueki Hiroko, Katagiri Hiroki, Tsuji Kunikazu, Miyatake Kazumasa, Watanabe Toshifumi, Sekiya Ichiro, Muneta Takeshi, Koga Hideyuki. 外傷後変形性関節症ラットモデルにおいて間葉系幹細胞の移植数が軟骨変性予防と疼痛緩和に及ぼす影響(Effect of transplanted mesenchymal stem cell number on the prevention of cartilage degeneration and pain reduction in a posttraumatic osteoarthritis rat model) Journal of Orthopaedic Science. 2021.07; 26 (4): 690-697. ( ichushi )

90. Ichiro Sekiya, Yuji Kohno, Akinobu Hyodo, Hisako Katano, Keiichiro Komori, Hideyuki Koga, Makoto Tomita, Kenji Suzuki, Jun Masumoto, Nobutake Ozeki. Interscan measurement error of knee cartilage thickness and projected cartilage area ratio at 9 regions and 45 subregions by fully automatic three-dimensional MRI analysis. Eur J Radiol. 2021.06; 139 109700. ( PubMed, DOI )

91. Kiyotaka Horiuchi, Nobutake Ozeki, Kentaro Endo, Mitsuru Mizuno, Hisako Katano, Masako Akiyama, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Thawed cryopreserved synovial mesenchymal stem cells show comparable effects to cultured cells in the inhibition of osteoarthritis progression in rats. Sci Rep. 2021.05; 11 (1): 9683. ( PubMed, DOI )

92. Kawata, K; Katagiri, H; Tsuji, K; Miyatake, K; Nakagawa, Y; Sekiya, I; Koga, H. EXOSOMES DERIVED FROM MSCS REPAIR MENISCUS DEFECTS AND ENHANCED ENDOGENOUS CELL PROLIFERATION AND MIGRATION VIA CXCL5 AND CXCL6/CXCR2 SIGNALING OSTEOARTHRITIS AND CARTILAGE. 2021.04; 29 S38-S39.

93. Ichiro Sekiya, Hisako Katano, Nobutake Ozeki. Characteristics of MSCs in Synovial Fluid and Mode of Action of Intra-Articular Injections of Synovial MSCs in Knee Osteoarthritis. Int J Mol Sci. 2021.03; 22 (6): 2838. ( PubMed, DOI )

94. J-S An, K Tsuji, H Onuma, N Araya, M Isono, T Hoshino, K Inomata, J Hino, M Miyazato, H Hosoda, K Kangawa, Y Nakagawa, H Katagiri, K Miyatake, I Sekiya, T Muneta, H Koga. Inhibition of fibrotic changes in infrapatellar fat pad alleviates persistent pain and articular cartilage degeneration in monoiodoacetic acid-induced rat arthritis model. Osteoarthritis Cartilage. 2021.03; 29 (3): 380-388. ( PubMed, DOI )

95. Hideyuki Koga, Tomomasa Nakamura, Yusuke Nakagawa, Nobutake Ozeki, Toshiyuki Ohara, Mikio Shioda, Yuji Kohno, Masaki Amemiya, Ichiro Sekiya. Arthroscopic Centralization Using Knotless Anchors for Extruded Medial Meniscus. Arthrosc Tech. 2021.03; 10 (3): e639-e645. ( PubMed, DOI )

96. Toshifumi Watanabe, Kazuyoshi Gamada, Hideyuki Koga, Ichiro Sekiya, Takeshi Muneta, Tetsuya Jinno. Characteristic kinematics of floor-sitting activities after posterior-stabilized total knee arthroplasty determined using model-based shape-matching techniques. Knee. 2021.03; 29 571-579. ( PubMed, DOI )

97. Weiding Cui, Yusuke Nakagawa, Hiroki Katagiri, Koji Otabe, Toshiyuki Ohara, Mikio Shioda, Yuji Kohno, Takashi Hoshino, Aritoshi Yoshihara, Ichiro Sekiya, Hideyuki Koga. Knee laxity, lateral meniscus tear and distal femur morphology influence pivot shift test grade in ACL injury patients. Knee Surg Sports Traumatol Arthrosc. 2021.02; 29 (2): 633-640. ( PubMed, DOI )

98. Nobutake Ozeki, Yuji Kohno, Yoshihisa Kushida, Naoto Watanabe, Mitsuru Mizuno, Hisako Katano, Jun Masumoto, Hideyuki Koga, Ichiro Sekiya. Synovial mesenchymal stem cells promote the meniscus repair in a novel pig meniscus injury model. J. Orthop. Res.. 2021.01; 39 (1): 177-183. ( PubMed, DOI )

99. Kiyotaka Horiuchi, Mitsuru Mizuno, Hisako Katano, Kentaro Endo, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya.. Optimal initial cell density that yields the highest number of primary synovial mesenchymal stem cells in a clinical setting. J Med Dent Sci.. 2021.01; 68 17-26. ( DOI )

100. Horiuchi Kiyotaka, Mizuno Mitsuru, Katano Hisako, Endo Kentaro, Ozeki Nobutake, Tsuji Kunikazu, Koga Hideyuki, Sekiya Ichiro. 臨床実地にて初代滑膜間葉系幹細胞の数が最大となるような最適な初期細胞密度(Optimal initial cell density that yields the highest number of primary synovial mesenchymal stem cells in a clinical setting) Journal of Medical and Dental Sciences. 2021; 68 17-26. ( ichushi )

101. Yoshihisa Kushida, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Kunikazu Tsuji, Hideyuki Koga, Koichiro Kishima, Yoshio Soma, Ichiro Sekiya. Two- and three-dimensional optical coherence tomography to differentiate degenerative changes in a rat meniscectomy model. J Orthop Res. 2020.12; 38 (12): 2592-2600. ( PubMed, DOI )

102. Watanabe N, Endo K, Komori K, Ozeki N, Mizuno M, Katano H, Kohno Y, Tsuji K, Koga H, Sekiya I. Mesenchymal Stem Cells in Synovial Fluid Increase in Knees with Degenerative Meniscus Injury after Arthroscopic Procedures through the Endogenous Effects of CGRP and HGF. Stem cell reviews and reports. 2020.12; 16 (6): 1305-1315. ( PubMed, DOI )

103. Yoshie Seki, Hiroki Katagiri, Koji Otabe, Yusuke Nakagawa, Kazumasa Miyatake, Ichiro Sekiya, Hideyuki Koga. Investigation of association between the preoperative intra-articular anesthetic test and persistent pain after total knee arthroplasty. J Orthop Sci. 2020.11; 25 (6): 1055-1060. ( PubMed, DOI )

104. Hayato Aoki, Nobutake Ozeki, Hisako Katano, Akinobu Hyodo, Yugo Miura, Junpei Matsuda, Kimiko Takanashi, Kenji Suzuki, Jun Masumoto, Noriya Okanouchi, Takeo Fujiwara, Ichiro Sekiya. Relationship between medial meniscus extrusion and cartilage measurements in the knee by fully automatic three-dimensional MRI analysis. BMC Musculoskelet Disord. 2020.11; 21 (1): 742. ( PubMed, DOI )

105. Hideyuki Koga, Tomomasa Nakamura, Hiroki Katagiri, Yusuke Nakagawa, Nobutake Ozeki, Toshiyuki Ohara, Mikio Shioda, Yuji Kohno, Masaki Amemiya, Ichiro Sekiya. Two-Year Outcomes After Meniscoplasty by Capsular Advancement With the Application of Arthroscopic Centralization Technique for Lateral Compartment Knee Osteoarthritis. Am J Sports Med. 2020.11; 48 (13): 3154-3162. ( PubMed, DOI )

106. Seki Yoshie, Katagiri Hiroki, Otabe Koji, Nakagawa Yusuke, Miyatake Kazumasa, Sekiya Ichiro, Koga Hideyuki. 人工関節全置換術前の関節内麻酔テストと術後の持続性疼痛の関連の検討(Investigation of association between the preoperative intra-articular anesthetic test and persistent pain after total knee arthroplasty) Journal of Orthopaedic Science. 2020.11; 25 (6): 1055-1060. ( ichushi )

107. Yoichi Murata, Soshi Uchida, Hajime Utsunomiya, Akihisa Hatakeyama, Hirotaka Nakashima, Toshiharu Mori, Yoshiaki Yamanaka, Manabu Tsukamoto, Ichiro Sekiya, Johnny Huard, Marc J Philippon, Akinori Sakai. Differentiation Potential of Synovial Mesenchymal Stem Cells Isolated From Hip Joints Affected by Femoroacetabular Impingement Syndrome Versus Osteoarthritis. Arthroscopy. 2020.08; 36 (8): 2122-2133. ( PubMed, DOI )

108. Mitsuru Mizuno, Kentaro Endo, Hisako Katano, Ayako Tsuji, Naomi Kojima, Ken Watanabe, Norio Shimizu, Tomohiro Morio, Ichiro Sekiya. The environmental risk assessment of cell-processing facilities for cell therapy in a Japanese academic institution. PLoS ONE. 2020.08; 15 (8): e0236600. ( PubMed, DOI )

109. So Suzuki, Mitsuru Mizuno, Yuriko Sakamaki, Ayako Mimata, Kentaro Endo, Yuji Kohno, Nobutake Ozeki, Koji Otabe, Hisako Katano, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Morphological changes in synovial mesenchymal stem cells during their adhesion to the meniscus. Lab. Invest.. 2020.07; 100 (7): 916-927. ( PubMed, DOI )

110. Naoko Araya, Kazumasa Miyatake, Kunikazu Tsuji, Hiroki Katagiri, Yusuke Nakagawa, Takashi Hoshino, Hiroaki Onuma, Saisei An, Hirofumi Nishio, Yoshitomo Saita, Ichiro Sekiya, Hideyuki Koga. Intra-articular Injection of Pure Platelet-Rich Plasma Is the Most Effective Treatment for Joint Pain by Modulating Synovial Inflammation and Calcitonin Gene-Related Peptide Expression in a Rat Arthritis Model. Am J Sports Med. 2020.07; 48 (8): 2004-2012. ( PubMed, DOI )

111. Hiroaki Onuma, Kunikazu Tsuji, Takashi Hoshino, Kei Inomata, Mio Udo, Yusuke Nakagawa, Hiroki Katagiri, Kazumasa Miyatake, Toshifumi Watanabe, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Fibrotic changes in the infrapatellar fat pad induce new vessel formation and sensory nerve fiber endings that associate prolonged pain. J. Orthop. Res.. 2020.06; 38 (6): 1296-1306. ( PubMed, DOI )

112. Toshifumi Watanabe, Hideyuki Koga, Koji Otabe, Yusuke Nakagawa, Takeshi Muneta, Ichiro Sekiya, Tetsuya Jinno.. Coronal and sagittal laxity affects clinical outcomes in posterior-stabilized total knee arthroplasty: assessment of well-functioning knees. Knee Surg Sports Traumatol Arthrosc. . 2020.05; 28 (5): 1400-1409. ( PubMed, DOI )

113. Watanabe T, Koga H, Katagiri H, Otabe K, Nakagawa Y, Muneta T, Sekiya I, Jinno T. Correction to: Coronal and sagittal laxity affects clinical outcomes in posterior-stabilized total knee arthroplasty: assessment of well-functioning knees. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. 2020.05; 28 (5): 1410. ( PubMed, DOI )

114. Nakagawa Yusuke, Muneta Takeshi, Watanabe Toshifumi, Horie Masafumi, Nakamura Tomomasa, Otabe Koji, Katakura Mai, Sumi Yusuke, Sekiya Ichiro, Koga Hideyuki. 亜区域外側半月板切除術後に変形性関節症をきたしたラグビー選手に対する鏡視下centralization法による良好な臨床的改善とX線画像転帰　1症例報告(Arthroscopic centralization achieved good clinical improvements and radiographic outcomes in a rugby player with osteoarthritis after subtotal lateral meniscectomy: A case report) Journal of Orthopaedic Science. 2020.05; 25 (3): 537-543. ( ichushi )

115. Rei Kubota, Hideyuki Koga, Nobutake Ozeki, Junpei Matsuda, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Ichiro Sekiya. The effect of a centralization procedure for extruded lateral meniscus on load distribution in porcine knee joints at different flexion angles. BMC Musculoskelet Disord. 2020.04; 21 (1): 205. ( PubMed, DOI )

116. Naoko Araya, Hiroki Katagiri , Yusuke Nakagawa, Toshiyuki Ohara, Mikio Shioda, Yuji Kohno, Masaki Amemiya, Ichiro Sekiya, Hideyuki Koga.. Predictors of residual mechanical symptoms after meniscus surgery: data from the maks group Osteoarthritis and Cartilage. 2020.04; 28 (1): S221-S223.

117. Yoshihara, A; Katagiri, H; Yang, Y; Amano, Y; Nakagawa, Y; Miyatake, K; Tsuji, K; Sekiya, I; Koga, H. SYNOVIAL SUPERFICIAL CELLS PROLIFERATE TOWARD DEEPER LAYER OF SYNOVIUM IN A RAT MONOIODOACETIC ACID INDUCED ARTHRITIS MODEL OSTEOARTHRITIS AND CARTILAGE. 2020.04; 28 S198.

118. Masaki Amemiya, Kunikazu Tsuji, Hiroki Katagiri, Kazumasa Miyatake, Yusuke Nakagawa, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Synovial fluid-derived mesenchymal cells have non-inferior chondrogenic potential and can be utilized for regenerative therapy as substitute for synovium-derived cells. Biochem. Biophys. Res. Commun.. 2020.03; 523 (2): 465-472. ( PubMed, DOI )

119. Hiroki Katagiri, Kazumasa Miyatake, Toshifumi Watanabe, Masafumi Horie, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Validity of intraoperative observation of graft length change pattern for medial patellofemoral ligament reconstruction. J Orthop. 2020.03; 21 131-136. ( PubMed, DOI )

120. Kaori Nakamura, Tomomasa Nakamura, Masafumi Horie, Hiroki Katagiri, Koji Otabe, Yusuke Nakagawa, Masaki Amemiya, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Anatomic femoral tunnel placement is difficult by the transtibial technique: comparison of three different femoral tunnel drilling techniques in double-bundle anterior cruciate ligament reconstructions. Knee Surg Sports Traumatol Arthrosc. 2020.02; 28 (2): 584-593. ( PubMed, DOI )

121. Nobutake Ozeki, Hideyuki Koga, Junpei Matsuda, Yuji Kohno, Mitsuru Mizuno, Hisako Katano, Kunikazu Tsuji, Tomoyuki Saito, Takeshi Muneta, Ichiro Sekiya. Biomechanical analysis of the centralization procedure for extruded lateral menisci with posterior root deficiency in a porcine model. J Orthop Sci.. 2020.01; 25 (1): 161-166. ( PubMed, DOI )

122. Mai Katakura, Kaori Nakamura, Toshifumi Watanabe, Masafumi Horie, Tomomasa Nakamura, Hiroki Katagiri, Koji Otabe, Yusuke Nakagawa, Toshiyuki Ohara, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Risk factors for residual anterolateral rotational instability after double bundle anterior cruciate ligament reconstruction: Evaluation by quantitative assessment of the pivot shift phenomenon using triaxial accelerometer. Knee. 2020.01; 27 (1): 95-101. ( PubMed, DOI )

123. Hajime Utsunomiya, Ichiro Sekiya, Soshi Uchida.. Editorial Commentary:Are We Ready to Apply Stem Cell Therapy in Rotator Curr Tear Surgery? Arthroscopy.. 2020.01; 36 (1): 86-87. ( PubMed, DOI )

124. Ozeki Nobutake, Koga Hideyuki, Matsuda Junpei, Kohno Yuji, Mizuno Mitsuru, Katano Hisako, Tsuji Kunikazu, Saito Tomoyuki, Muneta Takeshi, Sekiya Ichiro. ブタモデルの後根欠損を伴う逸脱外側半月に対する中心化の生体力学的解析(Biomechanical analysis of the centralization procedure for extruded lateral menisci with posterior root deficiency in a porcine model) Journal of Orthopaedic Science. 2020.01; 25 (1): 161-166. ( ichushi )

125. Ishibashi Yasuyuki, Adachi Nobuo, Koga Hideyuki, Kondo Eiji, Kuroda Ryosuke, Mae Tatsuo, Uchio Yuji, Abe Nobuhiro, Araki Daisuke, Chiba Daisuke, Deie Masataka, Enokida Makoto, Fujimoto Eisaku, Fukui Naoshi, Furumatsu Takayuki, Hamada Masayuki, Hamasato Yujiro, Hashimoto Yusuke, Hiranaka Takahumi, Hiraoka Hisatada, Horaguchi Takashi, Horibe Syuji, Hoshino Yuichi, Ikeda Hiroo, Ikeda Hiroshi, Ikeda Kotaro, Ikeuchi Masahiko, Inoue Masayuki, Ishida Kazunari, Kamimura Tamiko, Kanamori Akihiro, Katagiri Hiroki, Kimura Yuka, Kinugasa Tomonori, Kita Keisuke, Kitamura Nobuto, Kobayashi Tatsuo, Kumahashi Nobuyuki, Kurokouchi Kazutoshi, Kuwata Suguru, Maeda Akira, Maeda Shugo, Marumo Keishi, Maruyama Yuichiro, Matsuda Shuichi, Matsumoto Tomoyuki, Matsushita Takehiko, Matsusue Yoshitaka, Mine Takatomo, Mitani Genya, Miura Kazutomo, Miura Hiromasa, Miyatake Shin, Mochizuki Tomoyuki, Mori Satoshi, Muratsu Hirotsugu, Nakagawa Koichi, Nakagawa Takumi, Nakagawa Yasuaki, Nakamae Atsuo, Nakamura Eiichi, Nakamura Norimasa, Nakase Junsuke, Niki Yasuo, Nishimori Makoto, Nishizawa Yuichiro, Ochiai Satoshi, Ogawa Munehiro, Ogiuchi Takashi, Ohsawa Takashi, Oka Shinya, Okazaki Ken, Omori Go, Oouchi Hiroshi, Sakai Hiroya, Sakai Tadahiro, Sasaki Eiji, Sasaki Shizuka, Sasho Takahisa, Sato Takashi, Sekiya Hitoshi, Sekiya Ichiro, Shimizu Kuniaki, Soda Yoshinori, Soejima Takashi, Sonoda Masaki, Sugita Takehiko, Sumen Yoshio, Suzuki Tomoyuki, Tachibana Yomei, Takahashi Shigeo, Takahashi Toshiaki, Takazawa Yuji, Taketomi Shuji, Tanaka Takaaki, Tanaka Yoshinari, Terauchi Masanori, Tohyama Harukazu, Toritsuka Yukiyoshi, Tsuchiya Akihiro, Tsuda Eiichi, Tsukahara Takashi, Tsumura Hiroshi, Uchida Soshi, Urabe Ken, Yagishita Kazuyoshi, Yamaguchi Motoi, Yamamoto Kengo, Yamamoto Yuji, Yonetani Yasukazu, Yoshiya Shinichi, Watanabe Atsuya, Watanabe Toshifumi, The Japanese Orthopaedic Association, Systematic review team. 日本整形外科学会(JOA)の前十字靱帯損傷診療ガイドライン　二次出版(Japanese Orthopaedic Association (JOA) clinical practice guidelines on the management of anterior cruciate ligament injury: Secondary publication) Journal of Orthopaedic Science. 2020.01; 25 (1): 6-45. ( ichushi )

126. Hiroki Katagiri, Kazumasa Miyatake, Yusuke Nakagawa, Koji Otabe, Toshiyuki Ohara, Mikio Shioda, Ichiro Sekiya, Hideyuki Koga. The effect of a longitudinal tear of the medial meniscus on medial meniscal extrusion in anterior cruciate ligament injury patients. Knee. 2019.12; 26 (6): 1292-1298. ( PubMed, DOI )

127. Mitsuru Mizuno, Hisako Katano, Yuri Shimozaki, Sho Sanami, Nobutake Ozeki, Hideyuki Koga, Ichiro Sekiya. Time-lapse image analysis for whole colony growth curves and daily distribution of the cell number per colony during the expansion of mesenchymal stem cells. Sci Rep. 2019.11; 9 (1): 16835. ( PubMed, DOI )

128. Naoto Watanabe, Mitsuru Mizuno, Junpei Matsuda, Naoko Nakamura, Koji Otabe, Hisako Katano, Nobutake Ozeki, Yuji Kohno, Tsuyoshi Kimura, Kunikazu Tsuji, Hideyuki Koga, Akio Kishida, Ichiro Sekiya. Comparison of High-Hydrostatic-Pressure Decellularized Versus Freeze-Thawed Porcine Menisci. J. Orthop. Res.. 2019.11; 37 (11): 2466-2475. ( PubMed, DOI )

129. Ichiro Sekiya, Hideyuki Koga, Koji Otabe, Yusuke Nakagawa, Hisako Katano, Nobutake Ozeki, Mitsuru Mizuno, Masafumi Horie, Yuji Kohno, Kenta Katagiri, Naoto Watanabe, Takeshi Muneta. Additional Use of Synovial Mesenchymal Stem Cell Transplantation Following Surgical Repair of a Complex Degenerative Tear of the Medial Meniscus of the Knee: A Case Report. Cell Transplant. 2019.11; 28 (11): 1445-1454. ( PubMed, DOI )

130. Miwa S, Okamoto H, Yamada S, Kawaguchi Y, Endo K, Aiba H, Hayashi K, Kimura H, Sekiya I, Otsuka T, Tsuchiya H. Distribution of Solitary and Multiple Enchondromas of the Hand. In vivo (Athens, Greece). 2019.11; 33 (6): 2235-2240. ( PubMed, DOI )

131. Akinobu Hyodo, Nobutake Ozeki, Yuji Kohno, So Suzuki, Mitsuru Mizuno, Koji Otabe, Hisako Katano, Makoto Tomita, Yusuke Nakagawa, Hideyuki Koga, Shinji Kiuchi, Kenji Suzuki, Yoshinori Itai, Jun Masumoto, Ichiro Sekiya. Projected Cartilage Area Ratio Determined by 3-Dimensional MRI Analysis: Validation of a Novel Technique to Evaluate Articular Cartilage. JB JS Open Access. 2019.10; 4 (4): e0010. ( PubMed, DOI )

132. Yusuke Nakagawa, Toshifumi Watanabe, Yusuke Amano, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Mai Katakura, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Benefit of subcutaneous patient controlled analgesia after total knee arthroplasty. Asia Pac J Sports Med Arthrosc Rehabil Technol. 2019.10; 18 18-22. ( PubMed, DOI )

133. Shimpei Kondo, Yusuke Nakagawa, Mitsuru Mizuno, Kenta Katagiri, Kunikazu Tsuji, Shinji Kiuchi, Hideo Ono, Takeshi Muneta, Hideyuki Koga, Ichiro Sekiya. Transplantation of Aggregates of Autologous Synovial Mesenchymal Stem Cells for Treatment of Cartilage Defects in the Femoral Condyle and the Femoral Groove in Microminipigs. Am J Sports Med. 2019.08; 47 (10): 2338-2347. ( PubMed, DOI )

134. Ryota Fujisawa, Mitsuru Mizuno, Hisako Katano, Koji Otabe, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Cryopreservation in 95% serum with 5% DMSO maintains colony formation and chondrogenic abilities in human synovial mesenchymal stem cells. BMC Musculoskelet Disord. 2019.07; 20 (1): 316. ( PubMed, DOI )

135. Hiroko Ueki, Hiroki Katagiri, Koji Otabe, Yusuke Nakagawa, Toshiyuki Ohara, Mikio Shioda, Yuji Kohno, Takashi Hoshino, Ichiro Sekiya, Hideyuki Koga. Contribution of Additional Anterolateral Structure Augmentation to Controlling Pivot Shift in Anterior Cruciate Ligament Reconstruction. Am J Sports Med. 2019.07; 47 (9): 2093-2101. ( PubMed, DOI )

136. Naritomi Mana, Mizuno Mitsuru, Katano Hisako, Ozeki Nobutake, Otabe Koji, Komori Keiichiro, Fujii Shizuka, Ichinose Shizuko, Tsuji Kunikazu, Koga Hideyuki, Muneta Takeshi, Sekiya Ichiro.. Petaloid recombinant peptide enhances in vitro cartilage formation by synovial mesenchymal stem cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2019.06; 37 (6): 1350-1357. ( PubMed, DOI )

137. Kaori Nakamura, Kunikazu Tsuji, Mitsuru Mizuno, Hideyuki Koga, Takeshi Muneta, Ichiro Sekiya. Initial cell plating density affects properties of human primary synovial mesenchymal stem cells. J. Orthop. Res.. 2019.06; 37 (6): 1358-1367.

138. Akari Sasaki, Mitsuru Mizuno, Manabu Mochizuki, Ichiro Sekiya. Mesenchymal stem cells for cartilage regeneration in dogs. World J Stem Cells. 2019.05; 11 (5): 254-269. ( PubMed, DOI )

139. Sonoko Noda, Nobuyuki Kawashima, Mioko Yamamoto, Kentaro Hashimoto, Keisuke Nara, Ichiro Sekiya, Takashi Okiji. Effect of cell culture density on dental pulp-derived mesenchymal stem cells with reference to osteogenic differentiation. Sci Rep. 2019.04; 9 (1): 5430. ( PubMed, DOI )

140. Watanabe Toshifumi, Aoki Akino, Hoshi Kenji, Muneta Takeshi, Sekiya Ichiro, Koga Hideyuki. Anterior Tibial Post Impingement during Stair Climbing: A Kinematic Analysis and Clinical Outcome J Arthroplasty. 2019.02; 34 (2): 379-384.

141. Inomata Kei, Tsuji Kunilazu, Onuma Hroaki, Hoshino Takashi, Udo Mio, Akiyama Masako, Nakagawa Yusuke, Katagiri Hiroki, Miyatake Kazumasa, Sekiya Ichiro, Muneta Takeshi, Koga Hideyuki. Time course analyses of structural changes in the infrapatellar fat pad and synovial membrane during inflammation-induced persistent pain development in rat knee joint BMC Musculoskelet Disord. 2019.01; 20 (8):

142. Tomomasa Nakamura, Hideyuki Koga, Koji Otabe, Masafumi Horie, Toshifumi Watanabe, Kazuyoshi Yagishita, Ichiro Sekiya, Takeshi Muneta. Comparison of three approaches for femoral tunnel during double-bundle anterior cruciate ligament reconstruction: A case controlled study. J Orthop Sci. 2019.01; 24 (1): 147-152.

143. Mai Katakura, Masafumi Horie, Toshifumi Watanabe, Hiroki Katagiri, Koji Otabe, Toshiyuki Ohara, Kaori Nakamura, Kenta Katagiri, Hiroko Ueki, Stefano Zaffagnini, Ichiro Sekiya, Takeshi Muneta, Hideyuki Koga. Effect of meniscus repair on pivot-shift during anterior cruciate ligament reconstruction: Objective evaluation using triaxial accelerometer. Knee. 2019.01; 26 (1): 124-131. ( PubMed, DOI )

144. Nakamura Tomomasa, Koga Hideyuki, Otabe Koji, Horie Masafumi, Watanabe Toshifumi, Yagishita Kazuyoshi, Sekiya Ichiro, Muneta Takeshi. 二重束前十字靱帯再建中の大腿骨孔作成に用いられる3種類のアプローチの比較　症例対照研究(Comparison of three approaches for femoral tunnel during double-bundle anterior cruciate ligament reconstruction: A case controlled study) Journal of Orthopaedic Science. 2019.01; 24 (1): 147-152. ( ichushi )

145. Hiroko Ueki, Yusuke Nakagawa, Toshiyuki Ohara, Toshifumi Watanabe, Masafumi Horie, Hiroki Katagiri, Koji Otabe, Kenta Katagiri, Kanehiro Hiyama, Mai Katakura, Takashi Hoshino, Kei Inomata, Naoko Araya, Ichiro Sekiya. Risk factors for residual pivot shift after anterior cruciate ligament reconstruction: data from the MAKS group. Knee Surg Sports Traumatol Arthrosc. 2018.12; 26 (12): 3724-3730. ( PubMed, DOI )

146. Yoichi Murata, Soshi Uchida, Hajime Utsunomiya, Akihisa Hatakeyama, Hirotaka Nakashima, Angela Chang, Ichiro Sekiya, Akinori Sakai. Synovial mesenchymal stem cells derived from the cotyloid fossa synovium have higher self-renewal and differentiation potential than those from the paralabral synovium in the hip joint. American Journal of Sports Medicine. 2018.10; 46 (12): 2942-2953. ( PubMed, DOI )

147. Akari Sasaki, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Koji Otabe, Kunikazu Tsuji, Hideyuki Koga, Manabu Mochizuki, Ichiro Sekiya. Canine mesenchymal stem cells from synovium have a higher chondrogenic potential than those from infrapatellar fat pad, adipose tissue, and bone marrow. PLoS ONE. 2018.08; 13 (8): e0202922. ( PubMed, DOI )

148. Takashi Hoshino, Kunikazu Tsuji, Hiroaki Onuma, Mio Udo, Hiroko Ueki, Masako Akiyama, Kahaer Abula, Hiroki Katagiri, Kazumasa Miyatake, Toshihumi Watanabe, Ichiro Sekiya, Hideyuki Koga, Takeshi Muneta. Persistent synovial inflammation plays important roles in persistent pain development in the rat knee before cartilage degradation reaches the subchondral bone. BMC Musculoskelet Disord. 2018.08; 19 (1): 291. ( PubMed, DOI )

149. Katano H, Koga H, Ozeki N, Otabe K, Mizuno M, Tomita M, Muneta T, Sekiya I.. Trends in isolated meniscus repair and meniscectomy in Japan, 2011-2016. PLoS ONE. 2018.07; 23 (4): 676-681. ( PubMed )

150. Katano Hisako, Koga Hideyuki, Ozeki Nobutake, Otabe Koji, Mizuno Mitsuru, Tomita Makoto, Muneta Takeshi, Sekiya Ichiro. 日本における2011～2016年の分離半月板修復術と半月板切除術の傾向(Trends in isolated meniscus repair and meniscectomy in Japan, 2011-2016) Journal of Orthopaedic Science. 2018.07; 23 (4): 676-681. ( ichushi )

151. Ogata Yusuke, Mabuchi Yo, Shinoda Kosuke, Horiike Yuta, Mizuno Mitsuru, Otabe Koji, Suto Eriko Grace, Suzuki Nobuharu, Sekiya Ichiro, Akazawa Chihiro. Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage Regenerative Medicine. 2018.06; 8 20-28. ( PubMed, DOI )

152. Mari Uomizu, Takeshi Muneta, Miyoko Ojima, Ichiro Sekiya, Hideyuki Koga, Kunikazu Tsuji. PDGF-induced proliferation and differentiation of synovial mesenchymal stem cells is mediated by the PI3K-PKB/Akt pathway. J Med Dent Sci. 2018.06; 65 (2): 73-82.

153. Mindae Kim, Watanabe Toshifumi, Muneta Takeshi, Ohara Toshiyuki, Sekiya Ichiro, Koga Hideyuki. Bi-Surfaceタイプ3を用いた人工膝関節置換術の施行後において冠状面で評価した不安定性　平均して10年間にわたる経過観察研究(Coronal Instability after Total Knee Arthroplasty using Bi-Surface type 3: An Averaged 10 Year Follow-up Study) Journal of Medical and Dental Sciences. 2018.06; 65 (2): 51-58. ( ichushi )

154. Uomizu Mari, Muneta Takeshi, Ojima Miyoko, Sekiya Ichiro, Koga Hideyuki, Tsuji Kunikazu. PDGFが誘導する滑膜間葉系幹細胞の増殖と分化はPI3K-PKB/Akt経路によって媒介されている(PDGF-induced proliferation and differentiation of synovial mesenchymal stem cells is mediated by the PI3K-PKB/Akt pathway) Journal of Medical and Dental Sciences. 2018.06; 65 (2): 73-82. ( ichushi )

155. Ogata Yusuke, Mabuchi Yo, Shinoda Kosuke, Horiike Yuta, Mizuno Mitsuru, Otabe Koji, Suto Eriko Grace, Suzuki Nobuharu, Sekiya Ichiro, Akazawa Chihiro. 前十字靱帯に由来する間葉系間質細胞は靱帯へと分化する傾向を有している(Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage) Regenerative Therapy. 2018.06; 8 20-28. ( ichushi )

156. Mitsuru Mizuno, Hisako Katano, Yo Mabuchi, Yusuke Ogata, Shizuko Ichinose, Shizuka Fujii, Koji Otabe, Keiichiro Komori, Nobutake Ozeki, Hideyuki Koga, Kunikazu Tsuji, Chihiro Akazawa, Takeshi Muneta, Ichiro Sekiya. Specific markers and properties of synovial mesenchymal stem cells in the surface, stromal, and perivascular regions. Stem Cell Res Ther. 2018.05; 9 (1): 123. ( PubMed, DOI )

157. Takao Minami, Takeshi Muneta, Ichiro Sekiya, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Hiroki Katagiri, Koji Otabe, Toshiyuki Ohara, Mai Katakura, Hideyuki Koga. Lateral meniscus posterior root tear contributes to anterolateral rotational instability and meniscus extrusion in anterior cruciate ligament-injured patients. Knee Surg Sports Traumatol Arthrosc. 2018.04; 26 (4): 1174-1181. ( PubMed, DOI )

158. Ken Watanabe, Koji Otabe, Norio Shimizu, Keiichirou Komori, Mitsuru Mizuno, Hisako Katano, Hideyuki Koga, Ichiro Sekiya. High-sensitivity virus and mycoplasma screening test reveals high prevalence of parvovirus B19 infection in human synovial tissues and bone marrow. Stem Cell Res Ther. 2018.03; 9 (1): 80. ( PubMed, DOI )

159. Yuji Kohno, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Koji Otabe, Hideyuki Koga, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Ichiro Sekiya. Comparison of mesenchymal stem cells obtained by suspended culture of synovium from patients with rheumatoid arthritis and osteoarthritis. BMC Musculoskelet Disord. 2018.03; 19 (1): 78. ( PubMed, DOI )

160. Kanehiro Hiyama, Yusuke Nakagawa, Toshiyuki Ohara, Takeshi Muneta, Toshifumi Watanabe, Masafumi Horie, Koji Otabe, Hiroki Katagiri, Kenta Katagiri, Mai Katakura, Takashi Hoshino, Hiroko Ueki, Kei Inomata, Naoko Araya, Ichiro Sekiya, Hideyuki Koga. Anterior cruciate ligament injuries result in a larger functional deficit in fighting sport athletes: comparison of functional status among different sport types. Journal of ISAKOS. 2018.03; (3): 128-133.

161. Minami Takao, Koga Hideyuki, Sekiya Ichiro, Watanabe Toshifumi, Horie Masafumi, Katagiri Hiroki, Otabe Koji, Ohara Toshiyuki, Katakura Mai, Muneta Takeshi. 円板状外側半月板のある膝に対して大腿骨外側顆の骨形態学的特徴に応じて後方から挿入された前十字靱帯(Posteriorly inserted anterior cruciate ligament in knees with discoid lateral meniscus corresponding to bony morphological characteristics of femoral lateral condyle) Journal of Orthopaedic Science. 2018.03; 23 (2): 350-355. ( ichushi )

162. Kana Ishii, Hidetoshi Sakurai, Nobuharu Suzuki, Yo Mabuchi, Ichiro Sekiya, Kiyotoshi Sekiguchi, Chihiro Akazawa. Recapitulation of Extracellular LAMININ Environment Maintains Stemness of Satellite Cells In Vitro. Stem Cell Reports. 2018.02; 10 (2): 568-582. ( PubMed, DOI )

163. F P Luyten, S Bierma-Zeinstra, F Dell'Accio, V B Kraus, K Nakata, I Sekiya, N K Arden, L S Lohmander. Toward classification criteria for early osteoarthritis of the knee. Semin. Arthritis Rheum.. 2018.02; 47 (4): 457-463. ( PubMed, DOI )

164. Takuya Oyaizu, Mitsuhiro Enomoto, Naoki Yamamoto, Kunikazu Tsuji, Masaki Horie, Takeshi Muneta, Ichiro Sekiya, Atsushi Okawa, Kazuyoshi Yagishita. Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation. Sci Rep. 2018.01; 8 (1): 1288. ( PubMed, DOI )

165. Ishii Kana, Suzuki Nobuharu, Mabuchi Yo, Sekiya Ichiro, Akazawa Chihiro. Technical advantage of recombinant collagenase for isolation of muscle stem cells REGENERATIVE THERAPY. 2017.12; 7 1-7. ( PubMed, DOI )

166. Ishii Kana, Suzuki Nobuharu, Mabuchi Yo, Sekiya Ichiro, Akazawa Chihiro. Technical advantage of recombinant collagenase for isolation of muscle stem cells(和訳中) Regenerative Therapy. 2017.12; 7 1-7. ( ichushi )

167. Sekiya I, Kobayashi M, Okamoto H, Otsuka T. Progress and Role of Finger Joint Arthroscopy. Hand clinics. 2017.11; 33 (4): 819-829. ( PubMed, DOI )

168. Ichiro Sekiya, Darwin J.Prockop.. Beginning of an Unresolved Debate:Should Mesenchymal Stem Cells Be Expanded at Low Density to Preserve Early Progenitors? STEM CELLS 35Anniversary. 2017.09; 1 36-37.

169. Nakagawa Y, Muneta T, Watanabe T, Horie M, Nakamura T, Otabe K, Katakura M, Sumi Y, Sekiya I, Koga H. Arthroscopic centralization achieved good clinical improvements and radiographic outcomes in a rugby player with osteoarthritis after subtotal lateral meniscectomy: A case report. Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association. 2017.09; 25 (3): 537-543. ( PubMed, DOI )

170. Kaori Nakamura, Hideyuki Koga, Ichiro Sekiya, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Takeshi Muneta. Evaluation of pivot shift phenomenon while awake and under anaesthesia by different manoeuvres using triaxial accelerometer. Knee Surg Sports Traumatol Arthrosc. 2017.08; 25 (8): 2377-2383. ( PubMed, DOI )

171. Kei Inomata, Ichiro Sekiya, Koji Otabe, Tomomasa Nakamura, Masafumi Horie, Hideyuki Koga, Toshifumi Watanabe, Takeshi Muneta. Acute arterial occlusion after total knee arthroplasty: a case report. Clin Case Rep. 2017.08; 5 (8): 1376-1380. ( PubMed, DOI )

172. Hideyuki Koga, Toshifumi Watanabe, Masafumi Horie, Hiroki Katagiri, Koji Otabe, Toshiyuki Ohara, Mai Katakura, Ichiro Sekiya, Takeshi Muneta. Augmentation of the pullout repair of a medialmeniscus posterior root tear by arthroscopic centralization Arthroscopy techniques. 2017.08; 6 (4): 1335-1339. ( PubMed, DOI )

173. Carballo CB, Nakagawa Y, Sekiya I, Rodeo SA.. Basic Science of Articular Cartilage. Clin Sports Med.. 2017.07; 36 (3): 413-425.

174. Eriko Grace Suto, Yo Mabuchi, Nobuharu Suzuki, Koji Suzuki, Yusuke Ogata, Miyu Taguchi, Takeshi Muneta, Ichiro Sekiya, Chihiro Akazawa. Prospectively isolated mesenchymal stem/stromal cells are enriched in the CD73(+) population and exhibit efficacy after transplantation. Sci Rep. 2017.07; 7 (1): 4838. ( PubMed, DOI )

175. Toshifumi Watanabe, Hideyuki Koga, Masafumi Horie, Hiroki Katagiri, Ichiro Sekiya, Takeshi Muneta. Post-Cam Design and Contact Stress on Tibial Posts in Posterior-Stabilized Total Knee Prostheses: Comparison Between a Rounded and a Squared Design. J Arthroplasty. 2017.07; 32 (12): 3757-3762. ( PubMed, DOI )

176. Carballo Camila B., Nakagawa Yusuke, Sekiya Ichiro, Rodeo Scott A.. Basic Science of Articular Cartilage CLINICS IN SPORTS MEDICINE. 2017.07; 36 (3): 413-+. ( PubMed, DOI )

177. Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yuji Kohno, Shizuka Fujii, Nobutake Ozeki, Masafumi Horie, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta, Ichiro Sekiya. Complete human serum maintains viability and chondrogenic potential of human synovial stem cells: suitable conditions for transplantation. Stem Cell Res Ther. 2017.06; 8 (1): 144. ( PubMed, DOI )

178. Kunikazu Tsuji, Miyoko Ojima, Koji Otabe, Masafumi Horie, Hideyuki Koga, Ichiro Sekiya, Takeshi Muneta. Effects of Different Cell-Detaching Methods on the Viability and Cell Surface Antigen Expression of Synovial Mesenchymal Stem Cells. Cell Transplant. 2017.06; 26 (6): 1089-1102. ( PubMed, DOI )

179. Sekiya Ichiro. 動物モデルから臨床応用へ 膝関節の再生医療　疾患モデルから臨床治療へ(From Animal Models to Clinics Regenerative medicine for the knee joint: from disease models to clinical treatments) Experimental Animals. 2017.06; 66 (Suppl.): S15. ( ichushi )

180. Nobutake Ozeki, Takeshi Muneta, Kenichi Kawabata, Hideyuki Koga, Yusuke Nakagawa, Ryusuke Saito, Mio Udo, Katsuaki Yanagisawa, Toshiyuki Ohara, Tomoyuki Mochizuki, Kunikazu Tsuji, Tomoyuki Saito, Ichiro Sekiya. Centralization of extruded medial meniscus delays cartilage degeneration in rats. J Orthop Sci. 2017.05; 22 (3): 542-548. ( PubMed, DOI )

181. Mikio Shioda, Takeshi Muneta, Kunikazu Tsuji, Mitsuru Mizuno, Keiichiro Komori, Hideyuki Koga, Ichiro Sekiya. TNFα promotes proliferation of human synovial MSCs while maintaining chondrogenic potential. PLoS ONE. 2017.05; 12 (5): e0177771. ( PubMed, DOI )

182. Yuji Kohno, Mitsuru Mizuno, Nobutake Ozeki, Hisako Katano, Keiichiro Komori, Shizuka Fujii, Koji Otabe, Masafumi Horie, Hideyuki Koga, Kunikazu Tsuji, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Takeshi Muneta, Ichiro Sekiya. Yields and chondrogenic potential of primary synovial mesenchymal stem cells are comparable between rheumatoid arthritis and osteoarthritis patients. Stem Cell Res Ther. 2017.05; 8 (1): 115. ( PubMed, DOI )

183. Koga Hideyuki, Watanabe Toshifumi, Horie Masafumi, Katagiri Hiroki, Otabe Koji, Ohara Toshiyuki, Katakura Mai, Sekiya Ichiro, Muneta Takeshi. すべてが分かる半月板損傷の治療 半月板突出の関節鏡下centralization法と膝関節症における膝関節機能回復のための本手術法の応用(Arthroscopic Centralization of an Extruded Meniscus and Its Application to Knee Osteoarthritis to Restore Knee Function) JOSKAS. 2017.05; 42 (4): 526. ( ichushi )

184. Ozeki Nobutake, Muneta Takeshi, Kawabata Kenichi, Koga Hideyuki, Nakagawa Yusuke, Saito Ryusuke, Udo Mio, Yanagisawa Katsuaki, Ohara Toshiyuki, Mochizuki Tomoyuki, Tsuji Kunikazu, Saito Tomoyuki, Sekiya Ichiro. ラットの内側半月板逸脱に対するcentralizationにより軟骨変性が遅延する(Centralization of extruded medial meniscus delays cartilage degeneration in rats) Journal of Orthopaedic Science. 2017.05; 22 (3): 542-548. ( ichushi )

185. Katagiri Kenta, Yu Matsukura, Takeshi Muneta, Nobutake Ozeki, Mitsuru Mizuno, Hisako Katano, Ichiro Sekiya.. Fibrous synovium releases higher numbers of mesenchymal stem cells than adipose synovium in a suspended synovium culture model. Arthroscopy. 2017.04; 33 (4): 800-810. ( PubMed, DOI )

186. Jae-Sung An, Takeshi Muneta, Ichiro Sekiya, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Hideyuki Koga. Osteochondral lesion of lateral tibial plateau with extrusion of lateral meniscus treated with retrograde osteochondral autograft transplantation and arthroscopic centralisation. AP-SMART. 2017.04; 8 18-23. ( PubMed, DOI )

187. Ojima M., Tsuji K., Otabe K., Horie M., Koga H., Sekiya I., Muneta T.. ANALYSES OF BIOLOGICALLY ACTIVE SUBSTANCES IN SYNOVIAL FLUID WHICH SUPPORT PROLIFERATION OF SYNOVIAL MESENCHYMAL STEM CELLS OSTEOARTHRITIS AND CARTILAGE. 2017.04; 25 S425-S426.

188. Watanabe Toshifumi, Muneta Takeshi, Koga Hideyuki, Horie Masafumi, Otabe Koji, Ohara Toshiyuki, Nakamura Kaori, Katakura Mai, Okawa Atsushi, Sekiya Ichiro. 人工膝関節全置換術における脛骨ポストに対するカム後部設計と接触ストレス　円形と角型デザインの比較(Post-cam design and contact stress on tibial posts in total knee prostheses: Comparison between a rounded and a squared design) 日本整形外科学会雑誌. 2017.03; 91 (2): S453. ( ichushi )

189. Yuuki Arata, Muneta Takeshi, Ohara Toshiyuki, Sekiya Ichiro, Koga Hideyuki. 前十字靱帯損傷膝における外側/内側膝不安定性とその関連要因との相関(Associated lateral/medial knee instability and its relevant factors in anterior cruciate ligament-injured knees) Journal of Orthopaedic Science. 2017.03; 22 (2): 300-305. ( ichushi )

190. Yuuki A, Muneta T, Ohara T, Sekiya I, Koga H.. Associated lateral/medial knee instability and its relevant factors in anterior cruciate ligament-injured knees. J Orthop Sci. 2017.03; 22 (2): 300-305. ( PubMed, DOI )

191. Matsumura E, Tsuji K, Komori K, Koga H, Sekiya I, Muneta T.. Pretreatment of IL-1β enhances proliferation and chondrogenic potential of synovium-derived mesenchymal stem cells. Cytotherapy. 2017.02; 19 (2): 181-193. ( PubMed, DOI )

192. Akihisa Hatakeyama, Soshi Uchida, Hajime Utsunomiya, Manabu Tsukamoto, Hirotaka Nakashima, Eiichiro Nakamura, Cecilia Pascual-Garrido, Ichiro Sekiya, Akinori Sakai. Isolation and Characterization of Synovial Mesenchymal Stem Cell Derived from Hip Joints: A Comparative Analysis with a Matched Control Knee Group. Stem Cells Int. 2017.01; 2017 9312329. ( PubMed, DOI )

193. Saito R, Muneta T, Ozeki N, Nakagawa Y, Udo M, Yanagisawa K, Tsuji K, Tomita M, Koga H, Sekiya I.. Strenuous running exacerbates knee cartilage erosion induced by low amount of mono-iodoacetate in rats. BMC Musculoskelet Disord. 2017.01; 18 (1): 36. ( PubMed, DOI )

194. Inoue M, Muneta T, Ojima M, Nakamura K, Koga H, Sekiya I, Okazaki M, Tsuji K.. Inflammatory cytokine levels in synovial fluid 3, 4 days postoperatively and its correlation with early-phase functional recovery after anterior cruciate ligament reconstruction: a cohort study. J Exp Orthop.. 2016.12; 3 (1): 30. ( PubMed )

195. Shirasawa S, Koga H, Horie M, Nakamura T, Watanabe T, Sekiya I, Muneta T.. Forced knee extension test is a manual test that correlates with the unstable feelings of patients with ACL injury before and after reconstruction. Knee. 2016.12; 23 (6): 1159-1163. ( PubMed )

196. Kaori Nakamura, Hideyuki Koga, Ichiro Sekiya, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Takeshi Muneta. Dynamic Evaluation of Pivot-Shift Phenomenon in Double-Bundle Anterior Cruciate Ligament Reconstruction Using Triaxial Accelerometer. Arthroscopy. 2016.12; 32 (12): 2532-2538. ( PubMed, DOI )

197. Toshiyuki Ohara, Takeshi Muneta, Yusuke Nakagawa, Yu Matsukura, Shizuko Ichinose, Hideyuki Koga, Kunikazu Tsuji, Ichiro Sekiya. <Original Article>Hypoxia enhances proliferation through increase of colony formation rate with chondrogenic potential in primary synovial mesenchymal stem cells. J. Med. Dent. Sci.. 2016.12; 63 (4): 61-70. ( PubMed, DOI )

198. Kanehiro Hiyama, Takeshi Muneta, Hideyuki Koga, Ichiro Sekiya, Kunikazu Tsuji. Meniscal regeneration after resection of the anterior half of the medial meniscus in mice. J. Orthop. Res.. 2016.11; 35 (9): 1958-1965. ( PubMed, DOI )

199. Watanabe T, Muneta T, Koga H, Horie M, Nakamura T, Otabe K, Nakagawa Y, Katakura M, Sekiya I.. In-vivo kinematics of high-flex posterior-stabilized total knee prosthesis designed for Asian populations. Int Orthop. 2016.11; 40 (11): 2295-2302. ( PubMed, DOI )

200. Koga H, Muneta T, Watanabe T, Mochizuki T, Horie M, Nakamura T, Otabe K, Nakagawa Y, Sekiya I.. Two-Year Outcomes After Arthroscopic Lateral Meniscus Centralization Arthroscopy. 2016.10; 32 (10): 2000-2008.

201. Takeshi Muneta, Hideyuki Koga, Tomomasa Nakamura, Masafumi Horie, Toshifumi Watanabe, Ichiro Sekiya. Behind-remnant arthroscopic observation and scoring of femoral attachment of injured anterior cruciate ligament. Knee Surg Sports Traumatol Arthrosc. 2016.09; 24 (9): 2906-2914. ( PubMed, DOI )

202. Hiroki Katagiri, Kaori Nakamura, Toshifumi Watanabe, Hideyuki Koga, Kazuyoshi Yagishita, Ichiro Sekiya, Takeshi Muneta. Increase of patellofemoral height has decreased maximum knee flexion after total knee arthroplasty of posterior cruciate-substituting prosthesis in a clinical series. J Orthop Sci. 2016.07; 21 (4): 458-462. ( PubMed, DOI )

203. Mio Udo, Takeshi Muneta, Kunikazu Tsuji, Nobutake Ozeki, Yusuke Nakagawa, Toshiyuki Ohara, Ryusuke Saito, Katsuaki Yanagisawa, Hideyuki Koga, Ichiro Sekiya. Monoiodoacetic acid induces arthritis and synovitis in rats in a dose- and time-dependent manner: proposed model-specific scoring systems. Osteoarthr. Cartil.. 2016.07; 24 (7): 1284-1291. ( PubMed, DOI )

204. N Ozeki, T Muneta, H Koga, Y Nakagawa, M Mizuno, K Tsuji, Y Mabuchi, C Akazawa, E Kobayashi, K Matsumoto, K Futamura, T Saito, I Sekiya. Not single but periodic injections of synovial mesenchymal stem cells maintain viable cells in knees and inhibit osteoarthritis progression in rats. Osteoarthr. Cartil.. 2016.06; 24 (6): 1061-1070. ( PubMed, DOI )

205. Mai Katakura, Hideyuki Koga, Kaori Nakamura, Ichiro Sekiya, Takeshi Muneta. Effects of different femoral tunnel positions on tension changes in anterolateral ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2016.05; 25 (4): 1272-1278. ( PubMed, DOI )

206. Kazumasa Miyatake, Takeshi Muneta, Miyoko Ojima, Jun Yamada, Yu Matsukura, Kahaer Abula, Ichiro Sekiya, Kunikazu Tsuji. Coordinate and synergistic effects of extensive treadmill exercise and ovariectomy on articular cartilage degeneration. BMC Musculoskelet Disord. 2016.05; 17 (1): 238. ( PubMed, DOI )

207. Katsuaki Yanagisawa, Takeshi Muneta, Nobutake Ozeki, Yusuke Nakagawa, Mio Udo, Ryusuke Saito, Hideyuki Koga, Kunikazu Tsuji, Ichiro Sekiya. Weekly injections of Hylan G-F 20 delay cartilage degeneration in partial meniscectomized rat knees. BMC Musculoskelet Disord. 2016.04; 17 (1): 188. ( PubMed, DOI )

208. Toshifumi Watanabe, Takeshi Muneta, Kazuyoshi Yagishita, Kenji Hara, Hideyuki Koga, Ichiro Sekiya. Closed Suction Drainage Is Not Necessary for Total Knee Arthroplasty: A Prospective Study on Simultaneous Bilateral Surgeries of a Mean Follow-Up of 5.5 Years. J Arthroplasty. 2016.03; 31 (3): 641-645. ( PubMed, DOI )

209. Shimpei Kondo, Takeshi Muneta, Yusuke Nakagawa, Hideyuki Koga, Toshifumi Watanabe, Kunikazu Tsuji, Shinichi Sotome, Atsushi Okawa, Shinji Kiuchi, Hideo Ono, Mitsuru Mizuno, Ichiro Sekiya. Transplantation of autologous synovial mesenchymal stem cells promotes meniscus regeneration in aged primates. J. Orthop. Res.. 2016.02; 35 (6): 1274-1282. ( PubMed, DOI )

210. Chisato Sato, Yoshitaka Iso, Takuya Mizukami, Koji Otabe, Masahiro Sasai, Masaaki Kurata, Takeyuki Sanbe, Ichiro Sekiya, Akira Miyazaki, Hiroshi Suzuki. Fibroblast growth factor-23 induces cellular senescence in human mesenchymal stem cells from skeletal muscle. Biochem. Biophys. Res. Commun.. 2016.02; 470 (3): 657-662. ( PubMed, DOI )

211. Yusuke Nakagawa, Ichiro Sekiya, Shimpei Kondo, Takashi Tabuchi, Shizuko Ichinose, Hideyuki Koga, Kunikazu Tsuji, Takeshi Muneta. Relationship between MRI T1 rho value and histological findings of intact and radially incised menisci in microminipigs. J Magn Reson Imaging. 2016.02; 43 (2): 434-445. ( PubMed, DOI )

212. Yusuke Nakagawa, Takeshi Muneta, Koji Otabe, Nobutake Ozeki, Mitsuru Mizuno, Mio Udo, Ryusuke Saito, Katsuaki Yanagisawa, Shizuko Ichinose, Hideyuki Koga, Kunikazu Tsuji, Ichiro Sekiya. Cartilage Derived from Bone Marrow Mesenchymal Stem Cells Expresses Lubricin In Vitro and In Vivo. PLoS ONE. 2016.02; 11 (2): e0148777. ( PubMed, DOI )

213. Muneta T, Koga H, Nakamura T, Horie M, Watanabe T, Yagishita K, Sekiya I. A new behind-remnant approach for remnant-preserving double-bundle anterior cruciate ligament reconstruction compared with a standard approach Knee Surg Sports Traumatol Arthrosc. 2015.12; 23 (12): 3743-3749.

214. Toshifumi Watanabe, Takeshi Muneta, Ichiro Sekiya, Scott A Banks. Intraoperative joint gaps and mediolateral balance affect postoperative knee kinematics in posterior-stabilized total knee arthroplasty. Knee. 2015.12; 22 (6): 527-534. ( PubMed, DOI )

215. Mitsuru Mizuno, Hisako Katano, Koji Otabe, Keiichiro Komori, Yukie Matsumoto, Shizuka Fujii, Nobutake Ozeki, Kunikazu Tsuji, Hideyuki Koga, Takeshi Muneta, Akifumi Matsuyama, Ichiro Sekiya. Platelet-derived growth factor (PDGF)-AA/AB in human serum are potential indicators of the proliferative capacity of human synovial mesenchymal stem cells. Stem Cell Res Ther. 2015.12; 6 (1): 243. ( PubMed, DOI )

216. Hideyuki Koga, Takeshi Muneta, Kazuyoshi Yagishita, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Ichiro Sekiya. Effect of Initial Graft Tension on Knee Stability and Graft Tension Pattern in Double-Bundle Anterior Cruciate Ligament Reconstruction. Arthroscopy. 2015.09; 31 (9): 1756-1763. ( PubMed, DOI )

217. Kivanc Atesok, Freddie H Fu, Ichiro Sekiya, Alexandra Stolzing, Mitsuo Ochi, Scott A Rodeo. Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential. Knee Surg Sports Traumatol Arthrosc. 2015.08; 25 (2): 626-636. ( PubMed, DOI )

218. Ichiro Sekiya, Takeshi Muneta, Masafumi Horie, Hideyuki Koga. Arthroscopic Transplantation of Synovial Stem Cells Improves Clinical Outcomes in Knees With Cartilage Defects. Clin. Orthop. Relat. Res.. 2015.07; 473 (7): 2316-2326. ( PubMed, DOI )

219. Hideyuki Koga, Takeshi Muneta, Kazuyoshi Yagishita, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Ichiro Sekiya. Evaluation of a behind-remnant approach for femoral tunnel creation in remnant-preserving double-bundle anterior cruciate ligament reconstruction - Comparison with a standard approach. Knee. 2015.06; 22 (3): 249-255. ( PubMed, DOI )

220. Nobutake Ozeki, Takeshi Muneta, Seiya Matsuta, Hideyuki Koga, Yusuke Nakagawa, Mitsuru Mizuno, Kunikazu Tsuji, Yo Mabuchi, Chihiro Akazawa, Eiji Kobayashi, Tomoyuki Saito, Ichiro Sekiya. Synovial mesenchymal stem cells promote meniscus regeneration augmented by an autologous Achilles tendon graft in a rat partial meniscus defect model. Stem Cells. 2015.06; 33 (6): 1927-1938. ( PubMed, DOI )

221. Yusuke Ogata, Yo Mabuchi, Mayu Yoshida, Eriko Grace Suto, Nobuharu Suzuki, Takeshi Muneta, Ichiro Sekiya, Chihiro Akazawa. Purified Human Synovium Mesenchymal Stem Cells as a Good Resource for Cartilage Regeneration. PLoS ONE. 2015.06; 10 (6): e0129096. ( PubMed, DOI )

222. Hideyuki Koga, Takeshi Muneta, Kazuyoshi Yagishita, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Ichiro Sekiya. Effect of Posterolateral Bundle Graft Fixation Angles on Clinical Outcomes in Double-Bundle Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial. Am J Sports Med. 2015.05; 43 (5): 1157-1164. ( PubMed, DOI )

223. Yusuke Nakagawa, Takeshi Muneta, Shimpei Kondo, Mitsuru Mizuno, Kazuo Takakuda, Shizuko Ichinose, Takashi Tabuchi, Hideyuki Koga, Kunikazu Tsuji, Ichiro Sekiya. Synovial mesenchymal stem cells promote healing after meniscal repair in microminipigs. Osteoarthr. Cartil.. 2015.05; 589 (11): 1240-1248. ( PubMed, DOI )

224. Kahaer Abula, Takeshi Muneta, Kazumasa Miyatake, Jun Yamada, Yu Matsukura, Makiko Inoue, Ichiro Sekiya, Daniel Graf, Aris N Economides, Vicki Rosen, Kunikazu Tsuji. Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age. FEBS Lett.. 2015.05; 589 (11): 1240-1248. ( PubMed, DOI )

225. Yu Matsukura, Takeshi Muneta, Kunikazu Tsuji, Kazumasa Miyatake, Jun Yamada, Kahaer Abula, Hideyuki Koga, Makoto Tomita, Ichiro Sekiya. Mouse synovial mesenchymal stem cells increase in yield with knee inflammation. J. Orthop. Res.. 2015.02; 33 (2): 246-253. ( PubMed, DOI )

226. Koji Otabe, Hiroyuki Nakahara, Akihiko Hasegawa, Tetsuya Matsukawa, Fumiaki Ayabe, Naoko Onizuka, Masafumi Inui, Shuji Takada, Yoshiaki Ito, Ichiro Sekiya, Takeshi Muneta, Martin Lotz, Hiroshi Asahara. Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo. J. Orthop. Res.. 2015.01; 33 (1): 1-8. ( PubMed, DOI )

227. Jun Yamada, Kunikazu Tsuji, Kazumasa Miyatake, Yu Matsukura, Kahaer Abula, Makiko Inoue, Ichiro Sekiya, Takeshi Muneta. Follistatin alleviates synovitis and articular cartilage degeneration induced by carrageenan. Int J Inflam. 2014.12; 959271. ( PubMed, DOI )

228. Hideyuki Koga, Takeshi Muneta, Kazuyoshi Yagishita, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Ichiro Sekiya. Effect of femoral tunnel position on graft tension curves and knee stability in anatomic double-bundle anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc. 2014.11; 22 (11): 2811-2820. ( PubMed, DOI )

229. Hideyuki Koga, Takeshi Muneta, Kazuyoshi Yagishita, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Koji Otabe, Ichiro Sekiya. Mid- to Long-term Results of Single-Bundle Versus Double-Bundle Anterior Cruciate Ligament Reconstruction: Randomized Controlled Trial. Arthroscopy. 2014.09; ( PubMed, DOI )

230. Takeshi Muneta, Hideyuki Koga, Tomomasa Nakamura, Masafumi Horie, Toshifumi Watanabe, Kazuyoshi Yagishita, Ichiro Sekiya. A new behind-remnant approach for remnant-preserving double-bundle anterior cruciate ligament reconstruction compared with a standard approach. Knee Surg Sports Traumatol Arthrosc. 2014.09; ( PubMed, DOI )

231. D Hatsushika, T Muneta, T Nakamura, M Horie, H Koga, Y Nakagawa, K Tsuji, S Hishikawa, E Kobayashi, I Sekiya. Repetitive allogeneic intraarticular injections of synovial mesenchymal stem cells promote meniscus regeneration in a porcine massive meniscus defect model. Osteoarthr. Cartil.. 2014.07; 22 (7): 941-950. ( PubMed, DOI )

232. Makiko Okuno, Takeshi Muneta, Hideyuki Koga, Nobutake Ozeki, Yusuke Nakagawa, Kunikazu Tsuji, Shinichi Yoshiya, Ichiro Sekiya. Meniscus regeneration by syngeneic, minor mismatched, and major mismatched transplantation of synovial mesenchymal stem cells in a rat model. J. Orthop. Res.. 2014.07; 32 (7): 928-936. ( PubMed, DOI )

233. Nobuharu Suzuki, Chihiro Mizuniwa, Kana Ishii, Yusuke Nakagawa, Kunikazu Tsuji, Takeshi Muneta, Ichiro Sekiya, Chihiro Akazawa. Teneurin-4, a transmembrane protein, is a novel regulator that suppresses chondrogenic differentiation. J. Orthop. Res.. 2014.07; 32 (7): 915-922. ( PubMed, DOI )

234. Hideyuki Koga, Takeshi Muneta, Kazuyoshi Yagishita, Toshifumi Watanabe, Tomoyuki Mochizuki, Masafumi Horie, Tomomasa Nakamura, Ichiro Sekiya. Effect of Notchplasty in Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction. Am J Sports Med. 2014.06; 42 (8): 1813-1821. ( PubMed, DOI )

235. Ichiro Sekiya, Seth S Leopold. Editor's spotlight/Take 5: Mesenchymal stem cells in synovial fluid increase after meniscus injury. Clin. Orthop. Relat. Res.. 2014.05; 472 (5): 1353-1356. ( PubMed, DOI )

236. Yu Matsukura, Takeshi Muneta, Kunikazu Tsuji, Hideyuki Koga, Ichiro Sekiya. Mesenchymal stem cells in synovial fluid increase after meniscus injury. Clin. Orthop. Relat. Res.. 2014.05; 472 (5): 1357-1364. ( PubMed, DOI )

237. Tomomasa Nakamura, Ichiro Sekiya, Takeshi Muneta, Eiji Kobayashi. [Articular cartilage regenerative therapy with synovial mesenchymal stem cells in a pig model]. Clin Calcium. 2013.12; 23 (12): 1741-1749. ( PubMed, DOI )

238. Koga Hideyuki, Muneta Takeshi, Yagishita Kazuyoshi, Ju Young-Jin, Sekiya Ichiro. Surgical management of grade 3 medial knee injuries combined with cruciate ligament injuries. Knee Surg Sports Traumatol Arthrosc. 2012.01; 20 (1): 88-94. ( PubMed, DOI )

239. Koga H, Muneta T, Yagishita K, Ju YJ, Sekiya I. The Effect of Graft Fixation Angles on Anteroposterior and Rotational Knee Laxity in Double-Bundle Anterior Cruciate Ligament Reconstruction: Evaluation Using Computerized Navigation Am J Sports Med. 2012;

240. Nakamura T, Sekiya I, Muneta T, Hatsushika D, Horie M, Tsuji K, Kawarasaki T, Watanabe A, Hishikawa S, Fujimoto Y, Tanaka H, Kobayashi E. Arthroscopic, histological, and MRI analyses of cartilage repair after a minimally invasive method of transplantation of allogeneic synovial mesenchymal stem cells into cartilage defects in pigs Cytotherapy. 2012;

241. Sekiya I, Morito T, Hara K, Yamazaki J, Ju YJ, Yagishita K, Mochizuki T, Tsuji K, Muneta T. Ketoprofen absorption by muscle and tendon after topical or oral administration in patients undergoing anterior cruciate ligament reconstruction. AAPS PharmSciTech. 2010.03; 11 (1): 154-158. ( PubMed, DOI )

242. Sekiya I, Tang T, Hayashi M, Morito T, Ju YJ, Mochizuki T, Muneta T. Periodic knee injections of BMP-7 delay cartilage degeneration induced by excessive running in rats. J Orthop Res. 2009.08; 27 (8): 1088-1092. ( PubMed, DOI )

243. Sekiya I, Larson BL, Vuoristo JT, Reger RL, Prockop DJ. Comparison of effect of BMP-2, -4, and -6 on in vitro cartilage formation of human adult stem cells from bone marrow stroma. Cell Tissue Res. 2005.05; 320 (2): 269-276. ( PubMed, DOI )

244. Sekiya I, Koopman P, Tsuji K, Mertin S, Harley V, Yamada Y, Shinomiya K, Nifuji A, Noda M. Dexamethasone enhances SOX9 expression in chondrocytes. J Endocrinol. 2001.06; 169 (3): 573-579. ( PubMed )

245. Sekiya I, Koopman P, Tsuji K, Mertin S, Harley V, Yamada Y, Shinomiya K, Niguji A, Noda M. Transcriptional suppression of Sox9 expression in chondrocytes by retinoic acid. J Cell Biochem Suppl. 2001; Suppl 36 71-78. ( PubMed )

246. Sekiya I, Tsuji K, Koopman P, Watanabe H, Yamada Y, Shinomiya K, Nifuji A, Noda M. SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6. J Biol Chem. 2000.04; 275 (15): 10738-10744. ( PubMed )