論文・総説 - 岡本　隆一

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  1. Ami Kawamoto, Kento Takenaka, Ryuichi Okamoto, Mamoru Watanabe, Kazuo Ohtsuka. Systematic review of artificial intelligence-based image diagnosis for inflammatory bowel disease. Dig Endosc. 2022.11; 34 (7): 1311-1319. ( PubMed, DOI )

  2. Shuhei Sekiguchi, Kaoru Tsuchiya, Yutaka Yasui, Kento Inada, Sakura Kirino, Koji Yamashita, Yuka Hayakawa, Leona Osawa, Mayu Higuchi, Kenta Takaura, Chiaki Maeyashiki, Shun Kaneko, Nobuharu Tamaki, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Yasuhiro Asahina, Ryuichi Okamoto, Masayuki Kurosaki, Namiki Izumi. Clinical usefulness of geriatric assessment in elderly patients with unresectable hepatocellular carcinoma receiving sorafenib or lenvatinib therapy. Cancer Rep (Hoboken). 2022.11; 5 (11): e1613. ( PubMed, DOI )

  3. Ami Kawamoto, Toshimitsu Fujii, Ryuji Mitani, Yasuhiro Suzuki, Tsunehito Yauchi, Ryuichi Okamoto. Serum Levels of Infliximab Biosimilar in a Child Delivered From a Mother Treated for Ulcerative Colitis. Inflamm Bowel Dis. 2022.08; 28 (8): 1298-1299. ( PubMed, DOI )

  4. Kazumi Takishima, Yasuharu Maeda, Noriyuki Ogata, Masashi Misawa, Yuichi Mori, Mayumi Homma, Tetsuo Nemoto, Yuki Miyata, Yoshika Akimoto, Kentaro Mochida, Yuki Takashina, Kenta Tanaka, Katsuro Ichimasa, Hiroki Nakamura, Seiko Sasanuma, Toyoki Kudo, Takemasa Hayashi, Kunihiko Wakamura, Hideyuki Miyachi, Toshiyuki Baba, Fumio Ishida, Kazuo Ohtsuka, Shin-Ei Kudo. Beyond complete endoscopic healing: Goblet appearance using an endocytoscope to predict future sustained clinical remission in ulcerative colitis. Dig Endosc. 2022.07; 34 (5): 1030-1039. ( PubMed, DOI )

  5. Shuji Hibiya, Kazuo Ohtsuka, Kento Takenaka, Ami Kawamoto, Yusuke Matsuyama, Yumi Udagawa, Maiko Motobayashi, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Ryuichi Okamoto, Mamoru Watanabe. Mucosal healing of small intestinal stricture is associated with improved prognosis post-dilation in Crohn's disease. BMC Gastroenterol. 2022.05; 22 (1): 218. ( PubMed, DOI )

  6. Masanori Kobayashi, Shomei Ryozawa, Kazuo Ohtsuka, Minoru Tanabe, Ryuichi Okamoto. A convenient and reliable method for endoscopic mapping biopsy of cholangiocarcinoma using a double-lumen cytology device. VideoGIE. 2022.05; 7 (5): 182-184. ( PubMed, DOI )

  7. Yasuharu Maeda, Shin-Ei Kudo, Noriyuki Ogata, Masashi Misawa, Marietta Iacucci, Mayumi Homma, Tetsuo Nemoto, Kazumi Takishima, Kentaro Mochida, Hideyuki Miyachi, Toshiyuki Baba, Kensaku Mori, Kazuo Ohtsuka, Yuichi Mori. Evaluation in real-time use of artificial intelligence during colonoscopy to predict relapse of ulcerative colitis: a prospective study. Gastrointest Endosc. 2022.04; 95 (4): 747-756.e2. ( PubMed, DOI )

  8. Satoshi Watanabe, Sakurako Kobayashi, Nobuhiko Ogasawara, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe, Kim B Jensen, Shiro Yui. Transplantation of intestinal organoids into a mouse model of colitis. Nat Protoc. 2022.03; 17 (3): 649-671. ( PubMed, DOI )

  9. Hiroki Matsuda, Yoichi Nibe-Shirakihara, Akiko Tamura, Emi Aonuma, Satoko Arakawa, Kana Otsubo, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Shigeomi Shimizu, Averil Ma, Mamoru Watanabe, Motohiro Uo, Ryuichi Okamoto, Shigeru Oshima. Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice. Biochem Biophys Res Commun. 2022.02; 592 74-80. ( PubMed, DOI )

  10. Kento Takenaka, Toshimitsu Fujii, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Chiaki Maeyashiki, Osamu Yamaji, Maiko Motobayashi, Akira Igarashi, Ryoichi Hanazawa, Shuji Hibiya, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe. Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study. Lancet Gastroenterol Hepatol. 2021.11; ( PubMed, DOI )

  11. Noriyuki Ogata, Kazuo Ohtsuka, Masataka Ogawa, Yasuharu Maeda, Fumio Ishida, Shin-Ei Kudo. Image-Enhanced Capsule Endoscopy Improves the Identification of Small Intestinal Lesions. Diagnostics (Basel). 2021.11; 11 (11): ( PubMed, DOI )

  12. Yuka Hayakawa, Kaoru Tsuchiya, Masayuki Kurosaki, Yutaka Yasui, Shun Kaneko, Yuki Tanaka, Shun Ishido, Kento Inada, Sakura Kirino, Koji Yamashita, Tsubasa Nobusawa, Hiroaki Matsumoto, Tatsuya Kakegawa, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Nobuharu Tamaki, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Yasuhiro Asahina, Ryuichi Okamoto, Namiki Izumi. Early experience of atezolizumab plus bevacizumab therapy in Japanese patients with unresectable hepatocellular carcinoma in real-world practice. Invest New Drugs. 2021.09; ( PubMed, DOI )

  13. Ai Minamidate, Michio Onizawa, Chikako Saito, Rie Hikichi, Tomoaki Mochimaru, Mai Murakami, Chiharu Sakuma, Takehito Asakawa, Yuichi Hiraoka, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe. A potent endocytosis inhibitor Ikarugamycin up-regulates TNF production. Biochem Biophys Rep. 2021.09; 27 101065. ( PubMed, DOI )

  14. Kento Inada, Shun Kaneko, Masayuki Kurosaki, Koji Yamashita, Sakura Kirino, Leona Osawa, Yuka Hayakawa, Shuhei Sekiguchi, Mayu Higuchi, Kenta Takaura, Chiaki Maeyashiki, Nobuharu Tamaki, Yutaka Yasui, Jun Itakura, Yuka Takahashi, Kaoru Tsuchiya, Hiroyuki Nakanishi, Ryuichi Okamoto, Namiki Izumi. Tenofovir alafenamide for prevention and treatment of hepatitis B virus reactivation and de novo hepatitis. JGH Open. 2021.09; 5 (9): 1085-1091. ( PubMed, DOI )

  15. Takehito Asakawa, Michio Onizawa, Chikako Saito, Rie Hikichi, Daiki Yamada, Ai Minamidate, Tomoaki Mochimaru, Shun-Ichiro Asahara, Yoshiaki Kido, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe. Oral administration of D-serine prevents the onset and progression of colitis in mice. J Gastroenterol. 2021.08; 56 (8): 732-745. ( PubMed, DOI )

  16. Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Shuang Wang, Yasuhiro Nemoto, Shigeru Oshima, Takeshi Tsubata, Takahiro Adachi, Yohei Kawano, Mamoru Watanabe, Richard S Blumberg, Ryuichi Okamoto, Takashi Nagaishi. Corrigendum to "CEACAM1 specifically suppresses B cell receptor signaling-mediated activation". Biochem Biophys Res Commun. 2021.08; 565 97. ( PubMed, DOI )

  17. Kento Takenaka, Ami Kawamoto, Shuji Hibiya, Kohei Suzuki, Toshimitsu Fujii, Maiko Motobayashi, Hiromichi Shimizu, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Mamoru Watanabe, Kazuo Ohtsuka. Higher concentrations of cytokine blockers are needed to obtain small bowel mucosal healing during maintenance therapy in Crohn's disease. Aliment Pharmacol Ther. 2021.07; 54 (8): 1052-1060. ( PubMed, DOI )

  18. A Kawamoto, K Takenaka, S Hibiya, K Ohtsuka, R Okamoto, M Watanabe. Serum Leucine-Rich α 2 Glycoprotein: A Novel Biomarker For Small Bowel Mucosal Activity in Crohn's Disease Clin Gastroenterol Hepatol. 2021.06; ( PubMed, DOI )

  19. Masanori Kobayashi, Akashi Fujita, Tomoya Ogawa, Yuki Tanisaka, Masafumi Mizuide, Nobuaki Kondo, Yuki Imaizumi, Takaaki Hirotsu, Shomei Ryozawa. Caenorhabditis elegans as a Diagnostic Aid for Pancreatic Cancer. Pancreas. 2021.06; 50 (5): 673-678. ( PubMed, DOI )

  20. Go Ito, Shiro Yui, Ryuichi Okamoto. A Cellular "Hub" Function to Resolve Colitis. Cell Mol Gastroenterol Hepatol. 2021.05; ( PubMed, DOI )

  21. Takashi Nagaishi, Taro Watabe, Kunihiko Kotake, Toshihiko Kumazawa, Tomomi Aida, Kohichi Tanaka, Ryuichi Ono, Fumitoshi Ishino, Takako Usami, Takamasa Miura, Satomi Hirakata, Hiroko Kawasaki, Naoya Tsugawa, Daiki Yamada, Kazuhiro Hirayama, Soichiro Yoshikawa, Hajime Karasuyama, Ryuichi Okamoto, Mamoru Watanabe, Richard S Blumberg, Takahiro Adachi. Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum. Gut. 2021.05; ( PubMed, DOI )

  22. Kento Takenaka, Kazuo Ohtsuka, Toshimitsu Fujii, Shiori Oshima, Ryuichi Okamoto, Mamoru Watanabe. Deep Neural Network Accurately Predicts Prognosis of Ulcerative Colitis Using Endoscopic Images. Gastroenterology. 2021.05; 160 (6): 2175-2177.e3. ( PubMed, DOI )

  23. Reiko Kuno, Go Ito, Ami Kawamoto, Yui Hiraguri, Hady Yuki Sugihara, Sayaka Takeoka, Sayaka Nagata, Junichi Takahashi, Mao Tsuchiya, Sho Anzai, Tomohiro Mizutani, Hiromichi Shimizu, Shiro Yui, Shigeru Oshima, Kiichiro Tsuchiya, Mamoru Watanabe, Ryuichi Okamoto. Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients. Biochem Biophys Rep. 2021.03; 25 100906. ( PubMed, DOI )

  24. Masanori Kobayashi, Tomoaki Tashima, Koji Nagata, Shinichi Sakuramoto, Akihiko Osaki, Shomei Ryozawa. Colorectal and gastric metastases from lobular breast cancer that resembled superficial neoplastic lesions. Clin J Gastroenterol. 2021.02; 14 (1): 103-108. ( PubMed, DOI )

  25. Shuji Hibiya, Yusuke Matsuyama, Toshimitsu Fujii, Chiaki Maeyashiki, Eiko Saito, Kimiko Ito, Hiromichi Shimizu, Ami Kawamoto, Maiko Motobayashi, Kento Takenaka, Masakazu Nagahori, Masayuki Kurosaki, Tsunehito Yauchi, Kazuo Ohtsuka, Takeo Fujiwara, Ryuichi Okamoto, Mamoru Watanabe. 5-aminosalicylate-intolerant patients are at increased risk of colectomy for ulcerative colitis. Aliment Pharmacol Ther. 2021.01; 53 (1): 103-113. ( PubMed, DOI )

  26. Mao Tsuchiya, Go Ito, Minami Hama, Sayaka Nagata, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Sho Anzai, Junichi Takahashi, Reiko Kuno, Sayaka Takeoka, Yui Hiraguri, Hady Yuki Sugihara, Tomohiro Mizutani, Shiro Yui, Shigeru Oshima, Kiichiro Tsuchiya, Mamoru Watanabe, Ryuichi Okamoto. Functional analysis of isoflavones using patient-derived human colonic organoids. Biochem Biophys Res Commun. 2021.01; 542 40-47. ( PubMed, DOI )

  27. Emi Aonuma, Akiko Tamura, Hiroki Matsuda, Takehito Asakawa, Yuriko Sakamaki, Kana Otsubo, Yoichi Nibe, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Tetsuya Nakamura, Motohiro Uo, Mamoru Watanabe, Ryuichi Okamoto, Shigeru Oshima. Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62. Biochem Biophys Res Commun. 2021.01; 542 17-23. ( PubMed, DOI )

  28. Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Shuang Wang, Yasuhiro Nemoto, Shigeru Oshima, Takeshi Tsubata, Takahiro Adachi, Yohei Kawano, Mamoru Watanabe, Richard S Blumberg, Ryuichi Okamoto, Takashi Nagaishi. CEACAM1 specifically suppresses B cell receptor signaling-mediated activation. Biochem Biophys Res Commun. 2021.01; 535 99-105. ( PubMed, DOI )

  29. Ryo Morikawa, Yasuhiro Nemoto, Yuki Yonemoto, Shohei Tanaka, Yuria Takei, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Kengo Nozaki, Tomohiro Mizutani, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto. Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal. Cell Mol Gastroenterol Hepatol. 2021; 11 (5): 1483-1503. ( PubMed, DOI )

  30. Shuji Hibiya, Yusuke Matsuyama, Toshimitsu Fujii, Chiaki Maeyashiki, Eiko Saito, Kimiko Ito, Hiromichi Shimizu, Ami Kawamoto, Maiko Motobayashi, Kento Takenaka, Masakazu Nagahori, Masayuki Kurosaki, Tsunehito Yauchi, Kazuo Ohtsuka, Takeo Fujiwara, Ryuichi Okamoto, Mamoru Watanabe. 5-aminosalicylate-intolerant patients are at increased risk of colectomy for ulcerative colitis. Aliment Pharmacol Ther. 2020.11;

  31. Taku Sato, Shun Ishikawa, Jumpei Asano, Hirona Yamamoto, Masayuki Fujii, Toshiro Sato, Kouhei Yamamoto, Keisuke Kitagaki, Takumi Akashi, Ryuichi Okamoto, Toshiaki Ohteki. Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages. Nat Cell Biol. 2020.08; 22 (8): 919-926. ( PubMed, DOI )

  32. Kana Otsubo, Chiaki Maeyashiki, Yoichi Nibe, Akiko Tamura, Emi Aonuma, Hiroki Matsuda, Masanori Kobayashi, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Satoru Torii, Eisuke Itakura, Mamoru Watanabe, Shigeru Oshima. Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells. FEBS Lett. 2020.05; 594 (10): 1586-1595. ( PubMed, DOI )

  33. Sho Anzai, Ami Kawamoto, Sayaka Nagata, Junichi Takahashi, Mao Kawai, Reiko Kuno, Sakurako Kobayashi, Satoshi Watanabe, Kohei Suzuki, Hiromichi Shimizu, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Shigeru Oshima, Mamoru Watanabe, Ryuichi Okamoto. TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells. Biochem Biophys Res Commun. 2020.04; 524 (3): 533-541. ( PubMed, DOI )

  34. Yuria Takei, Yasuhiro Nemoto, Ryo Morikawa, Shohei Tanaka, Shigeru Oshima, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. T cells show amoeboid shape and frequent morphological change in vitro, and localize to small intestinal intraepithelial region in vivo. Biochem. Biophys. Res. Commun.. 2020.03; 523 (2): 328-335. ( PubMed, DOI )

  35. Ryuichi Okamoto, Hiromichi Shimizu, Kohei Suzuki, Ami Kawamoto, Junichi Takahashi, Mao Kawai, Sayaka Nagata, Yui Hiraguri, Sayaka Takeoka, Hady Yuki Sugihara, Shiro Yui, Mamoru Watanabe. Organoid-based regenerative medicine for inflammatory bowel disease. Regen Ther. 2020.03; 13 1-6. ( PubMed, DOI )

  36. Shohei Tanaka, Yasuhiro Nemoto, Yuria Takei, Ryo Morikawa, Shigeru Oshima, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Susanne Stutte, Mamoru Watanabe. High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage. Biochem. Biophys. Res. Commun.. 2020.02; 522 (4): 971-977. ( PubMed, DOI )

  37. Sho Watanabe, Kiichiro Tsuchiya, Ryu Nishimura, Tomoaki Shirasaki, Nobuhiro Katsukura, Shuji Hibiya, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Mutation by CRISPR System Enhances the Malignant Potential of Colon Cancer. Mol. Cancer Res.. 2019.07; 17 (7): 1459-1467. ( PubMed, DOI )

  38. Hiromichi Shimizu, Kohei Suzuki, Mamoru Watanabe, Ryuichi Okamoto. Stem cell-based therapy for inflammatory bowel disease. Intest Res. 2019.07; 17 (3): 311-316. ( PubMed, DOI )

  39. Ami Kawamoto, Sayaka Nagata, Sho Anzai, Junichi Takahashi, Mao Kawai, Minami Hama, Daichi Nogawa, Kouhei Yamamoto, Reiko Kuno, Kohei Suzuki, Hiromichi Shimizu, Yui Hiraguri, Shiro Yui, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Masanobu Kitagawa, Ryuichi Okamoto, Mamoru Watanabe. Ubiquitin D is Upregulated by Synergy of Notch Signalling and TNF-α in the Inflamed Intestinal Epithelia of IBD Patients. J Crohns Colitis. 2019.03; 13 (4): 495-509. ( PubMed, DOI )

  40. Kohei Suzuki, Tatsuro Murano, Hiromichi Shimizu, Go Ito, Toru Nakata, Satoru Fujii, Fumiaki Ishibashi, Ami Kawamoto, Sho Anzai, Reiko Kuno, Konomi Kuwabara, Junichi Takahashi, Minami Hama, Sayaka Nagata, Yui Hiraguri, Kento Takenaka, Shiro Yui, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto. Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties. J. Gastroenterol.. 2018.09; 53 (9): 1035-1047. ( PubMed, DOI )

  41. Fumiaki Ishibashi, Hiromichi Shimizu, Toru Nakata, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Sho Anzai, Reiko Kuno, Sayaka Nagata, Go Ito, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto. Contribution of ATOH1+ Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium. Stem Cell Reports. 2018.01; 10 (1): 27-42. ( PubMed, DOI )

  42. Yoichi Nibe, Shigeru Oshima, Masanori Kobayashi, Chiaki Maeyashiki, Yu Matsuzawa, Kana Otsubo, Hiroki Matsuda, Emi Aonuma, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Shinichiro Nakada, Mamoru Watanabe. Novel polyubiquitin imaging system, PolyUb-FC, reveals that K33-linked polyubiquitin is recruited by SQSTM1/p62. Autophagy. 2018.01; 14 (2): 347-358. ( PubMed, DOI )

  43. Tatsuro Yoneyama, Midori A Arai, Ryuta Akamine, Kazune Koryudzu, Anna Tsuchiya, Samir K Sadhu, Firoj Ahmed, Motoyuki Itoh, Ryuichi Okamoto, Masami Ishibashi. Notch Inhibitors from Calotropis gigantea That Induce Neuronal Differentiation of Neural Stem Cells. J. Nat. Prod. 2017.09; 80 (9): 2453-2461. ( PubMed, DOI )

  44. Shuji Hibiya, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Nobukatsu Horita, Sho Watanabe, Tomoaki Shirasaki, Ryu Nishimura, Natsuko Kimura, Tatsunori Nishimura, Noriko Gotoh, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Long-term Inflammation Transforms Intestinal Epithelial Cells of Colonic Organoids. J Crohns Colitis. 2017.05; 11 (5): 621-630. ( PubMed, DOI )

  45. Chiaki Maeyashiki, Shigeru Oshima, Kana Otsubo, Masanori Kobayashi, Yoichi Nibe, Yu Matsuzawa, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells. Biochem. Biophys. Res. Commun. 2017.03; 484 (3): 636-641. ( PubMed, DOI )

  46. Toru Nakata, Hiromichi Shimizu, Sayaka Nagata, Go Ito, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Reiko Kuno, Sho Anzai, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe, Ryuichi Okamoto. Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine. Data Brief. 2017.02; 10 551-556. ( PubMed, DOI )

  47. Toru Nakata, Hiromichi Shimizu, Sayaka Nagata, Go Ito, Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Reiko Kuno, Sho Anzai, Tatsuro Murano, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe, Ryuichi Okamoto. Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors. Biochem. Biophys. Res. Commun. 2017.01; 482 (4): 1296-1303. ( PubMed, DOI )

  48. Satoru Fujii, Kohei Suzuki, Ami Kawamoto, Fumiaki Ishibashi, Toru Nakata, Tatsuro Murano, Go Ito, Hiromichi Shimizu, Tomohiro Mizutani, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Akihiro Araki, Kazuo Ohtsuka, Ryuichi Okamoto, Mamoru Watanabe. PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells. Sci Rep. 2016.11; 6 36795. ( PubMed, DOI )

  49. Ryuichi Okamoto, Mamoru Watanabe. Functional relevance of intestinal epithelial cells in inflammatory bowel disease. Nihon Rinsho Meneki Gakkai Kaishi. 2016.11; 39 (6): 522-527. ( PubMed, DOI )

  50. Masanori Kobayashi, Shigeru Oshima, Chiaki Maeyashiki, Yoichi Nibe, Kana Otsubo, Yu Matsuzawa, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development. Sci Rep. 2016.11; 6 36780. ( PubMed, DOI )

  51. Ryuichi Okamoto, Mariko Negi, Syohei Tomii, Yoshinobu Eishi, Mamoru Watanabe. Diagnosis and treatment of microscopic colitis. Clin J Gastroenterol. 2016.08; 9 (4): 169-174. ( PubMed, DOI )

  52. Ryohei Hayashi, Kiichiro Tsuchiya, Keita Fukushima, Nobukatsu Horita, Shuji Hibiya, Keisuke Kitagaki, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Shinji Fukuda, Hiroshi Ohno, Ryuichi Okamoto, Tetsuya Nakamura, Shinji Tanaka, Kazuaki Chayama, Mamoru Watanabe. Reduced Human α-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease. Inflamm. Bowel Dis.. 2016.05; 22 (5): 1119-1128. ( PubMed, DOI )

  53. Ryuichi Okamoto, Mamoru Watanabe. Investigating cell therapy for inflammatory bowel disease. Expert Opin Biol Ther. 2016.04; 1-9. ( PubMed, DOI )

  54. Satoshi Otani, Sei Kakinuma, Akihide Kamiya, Fumio Goto, Shun Kaneko, Masato Miyoshi, Tomoyuki Tsunoda, Yu Asano, Fukiko Kawai-Kitahata, Sayuri Nitta, Toru Nakata, Ryuichi Okamoto, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Yasuhiro Asahina, Tomoyuki Yamaguchi, Naohiko Koshikawa, Motoharu Seiki, Hiromitsu Nakauchi, Mamoru Watanabe. Matrix metalloproteinase-14 mediates formation of bile ducts and hepatic maturation of fetal hepatic progenitor cells. Biochem. Biophys. Res. Commun. 2016.01; 469 (4): 1062-1068. ( PubMed, DOI )

  55. Ryuichi Okamoto, Mamoru Watanabe. Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease. J. Gastroenterol. 2016.01; 51 (1): 11-21. ( PubMed, DOI )

  56. Ryuichi Okamoto, Mamoru Watanabe. Perspectives for Regenerative Medicine in the Treatment of Inflammatory Bowel Diseases. Digestion. 2015.07; 92 (2): 73-77. ( PubMed, DOI )

  57. Yu Matsuzawa, Shigeru Oshima, Masahiro Takahara, Chiaki Maeyashiki, Yasuhiro Nemoto, Masanori Kobayashi, Yoichi Nibe, Kengo Nozaki, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Averil Ma, Mamoru Watanabe. TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy. Autophagy. 2015.06; 11 (7): 1052-1062. ( PubMed, DOI )

  58. Keita Fukushima, Kiichiro Tsuchiya, Yoshihito Kano, Nobukatsu Horita, Shuji Hibiya, Ryohei Hayashi, Keisuke Kitagaki, Mariko Negi, Eisaku Itoh, Takumi Akashi, Yoshinobu Eishi, Shigeru Oshima, Takashi Nagaishi, Okamoto Ryuichi, Tetsuya Nakamura, Mamoru Watanabe. Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line. Cancer Sci. 2015.05; 106 (8): 1000-1007. ( PubMed, DOI )

  59. Yu Matsuzawa, Shigeru Oshima, Yoichi Nibe, Masanori Kobayashi, Chiaki Maeyashiki, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62. Biochem. Biophys. Res. Commun. 2015.01; 456 (1): 298-304. ( PubMed, DOI )

  60. Nobukatsu Horita, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Shuji Hibiya, Masayoshi Fukuda, Yoshihito Kano, Tomohiro Mizutani, Yasuhiro Nemoto, Shiro Yui, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt. Biochem. Biophys. Res. Commun. 2014.10; 454 (4): 493-499. ( PubMed, DOI )

  61. Hiromichi Shimizu, Ryuichi Okamoto, Go Ito, Satoru Fujii, Toru Nakata, Kohei Suzuki, Tatsuro Murano, Tomohiro Mizutani, Kiichiro Tsuchiya, Tetsuya Nakamura, Katsuto Hozumi, Mamoru Watanabe. Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine. PeerJ. 2014.05; 2 (1): e370. ( PubMed, DOI )

  62. Masahiro Suzuki, Takashi Nagaishi, Motomi Yamazaki, Michio Onizawa, Taro Watabe, Yuriko Sakamaki, Shizuko Ichinose, Mamoru Totsuka, Shigeru Oshima, Ryuichi Okamoto, Motoyuki Shimonaka, Hideo Yagita, Tetsuya Nakamura, Mamoru Watanabe. Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis. PLoS ONE. 2014.02; 9 (2): e88369. ( PubMed, DOI )

  63. Tatsuro Murano, Ryuichi Okamoto, Go Ito, Toru Nakata, Shuji Hibiya, Hiromichi Shimizu, Satoru Fujii, Yoshihito Kano, Tomohiro Mizutani, Shiro Yui, Junko Akiyama-Morio, Yasuhiro Nemoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells. Biochem. Biophys. Res. Commun. 2014.01; 443 (3): 840-846. ( PubMed, DOI )

  64. Okamoto R, Nagaori T, Watanabe M. Prespectives for IBD in Japan. AGA Perspectives. 2013.12; 9 (2): 18-19.

  65. Masahiro Takahara, Yasuhiro Nemoto, Shigeru Oshima, Yu Matsuzawa, Takanori Kanai, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Kazuhide Yamamoto, Mamoru Watanabe. IL-7 promotes long-term in vitro survival of unique long-lived memory subset generated from mucosal effector memory CD4+ T cells in chronic colitis mice. Immunol. Lett.. 2013.11; 156 (1-2): 82-93. ( PubMed, DOI )

  66. Go Ito, Ryuichi Okamoto, Tatsuro Murano, Hiromichi Shimizu, Satoru Fujii, Toru Nakata, Tomohiro Mizutani, Shiro Yui, Junko Akiyama-Morio, Yasuhiro Nemoto, Eriko Okada, Akihiro Araki, Kazuo Ohtsuka, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells. PLoS ONE. 2013.11; 8 (11): e79693. ( PubMed, DOI )

  67. Yasuhiro Nemoto, Takanori Kanai, Masahiro Takahara, Shigeru Oshima, Tetsuya Nakamura, Ryuichi Okamoto, Kiichiro Tsuchiya, Mamoru Watanabe. Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells. Gut. 2013.08; 62 (8): 1142-1152. ( PubMed, DOI )

  68. Yasuhiro Nemoto, Takanori Kanai, Masahiro Takahara, Shigeru Oshima, Ryuichi Okamoto, Kiichiro Tsuchiya, Satoshi Matsumoto, Mamoru Watanabe. Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota. J. Immunol.. 2013.06; 190 (12): 6616-6625. ( PubMed, DOI )

  69. Kei Kiyohashi, Sei Kakinuma, Akihide Kamiya, Naoya Sakamoto, Sayuri Nitta, Hideto Yamanaka, Kouhei Yoshino, Junko Fujiki, Miyako Murakawa, Akiko Kusano-Kitazume, Hiromichi Shimizu, Ryuichi Okamoto, Seishin Azuma, Mina Nakagawa, Yasuhiro Asahina, Naoki Tanimizu, Akira Kikuchi, Hiromitsu Nakauchi, Mamoru Watanabe. Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice. Hepatology. 2013.06; 57 (6): 2502-2513. ( PubMed, DOI )

  70. Yoshihito Kano, Kiichiro Tsuchiya, Xiu Zheng, Nobukatsu Horita, Keita Fukushima, Shuji Hibiya, Yuhki Yamauchi, Tatsunori Nishimura, Kunihiko Hinohara, Noriko Gotoh, Shinji Suzuki, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe. The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein. Biochem. Biophys. Res. Commun. 2013.03; 432 (1): 175-181. ( PubMed, DOI )

  71. Akihiro Araki, Kiichiro Tsuchiya, Shigeru Oshima, Eriko Okada, Shinji Suzuki, Junko Morio Akiyama, Toshimitsu Fujii, Ryuichi Okamoto, Mamoru Watanabe. Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel's diverticulum: a case report. J Med Case Rep. 2012.09; 6 (1): 328. ( PubMed, DOI )

  72. Tomohiro Mizutani, Tetsuya Nakamura, Ryo Morikawa, Masayoshi Fukuda, Wakana Mochizuki, Yuhki Yamauchi, Kengo Nozaki, Shiro Yui, Yasuhiro Nemoto, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Mamoru Watanabe. Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro. Biochem. Biophys. Res. Commun. 2012.03; 419 (2): 238-243. ( PubMed, DOI )

  73. Shiro Yui, Tetsuya Nakamura, Toshiro Sato, Yasuhiro Nemoto, Tomohiro Mizutani, Xiu Zheng, Shizuko Ichinose, Takashi Nagaishi, Ryuichi Okamoto, Kiichiro Tsuchiya, Hans Clevers, Mamoru Watanabe. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. Nat. Med.. 2012.03; 18 (4): 618-623. ( PubMed, DOI )

  74. Osamu Yamaji, Takashi Nagaishi, Teruji Totsuka, Michio Onizawa, Masahiro Suzuki, Naoto Tsuge, Atsuhiko Hasegawa, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Hisashi Arase, Takanori Kanai, Mamoru Watanabe. The development of colitogenic CD4(+) T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis. J. Immunol.. 2012.03; 188 (6): 2524-2536. ( PubMed, DOI )

  75. Yasuhiro Nemoto, Takanori Kanai, Tamako Shinohara, Takashi Ito, Tetsuya Nakamura, Ryuichi Okamoto, Kiichiro Tsuchiya, Martin Lipp, Yoshinobu Eishi, Mamoru Watanabe. Luminal CD4⁺ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation. Gastroenterology. 2011.12; 141 (6): 2130-2139.e11. ( PubMed, DOI )

  76. Xiu Zheng, Kiichiro Tsuchiya, Ryuichi Okamoto, Michiko Iwasaki, Yoshihito Kano, Naoya Sakamoto, Tetsuya Nakamura, Mamoru Watanabe. Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis. Inflamm. Bowel Dis.. 2011.11; 17 (11): 2251-2260. ( PubMed, DOI )

  77. Tamako Shinohara, Yasuhiro Nemoto, Takanori Kanai, Kaori Kameyama, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Teruji Totsuka, Koichi Ikuta, Mamoru Watanabe. Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. J. Immunol.. 2011.02; 186 (4): 2623-2632. ( PubMed, DOI )

  78. Michiko Iwasaki, Kiichiro Tsuchiya, Ryuichi Okamoto, Xiu Zheng, Yoshihito Kano, Eiko Okamoto, Eriko Okada, Akihiro Araki, Shinji Suzuki, Naoya Sakamoto, Keisuke Kitagaki, Takumi Akashi, Yoshinobu Eishi, Tetsuya Nakamura, Mamoru Watanabe. Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4. J. Gastroenterol.. 2011.02; 46 (2): 191-202. ( PubMed, DOI )

  79. Masakazu Nagahori, Sea Bong Hyun, Teruji Totsuka, Ryuichi Okamoto, Erika Kuwahara, Toru Takebayashi, Makoto Naganuma, Mamoru Watanabe. Prevalence of metabolic syndrome is comparable between inflammatory bowel disease patients and the general population. J. Gastroenterol.. 2010.10; 45 (10): 1008-1013. ( PubMed, DOI )

  80. Kaori Kameyama, Yasuhiro Nemoto, Takanori Kanai, Tamako Shinohara, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Naoya Sakamoto, Teruji Totsuka, Toshifumi Hibi, Mamoru Watanabe. IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis. Eur J Immunol. 2010.09; 40 (9): 2423-2436. ( PubMed, DOI )

  81. Junko Akiyama, Ryuichi Okamoto, Michiko Iwasaki, Xiu Zheng, Shiro Yui, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe. Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells. Biochem. Biophys. Res. Commun. 2010.03; 393 (4): 662-667. ( PubMed, DOI )

  82. Yasuhiro Nemoto, Takanori Kanai, Kaori Kameyama, Tamako Shinohara, Naoya Sakamoto, Teruji Totsuka, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Tetsuo Sudo, Satoshi Matsumoto, Mamoru Watanabe. Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis. J. Immunol.. 2009.10; 183 (8): 5059-5068. ( PubMed, DOI )

  83. Takayuki Tomita, Takanori Kanai, Teruji Totsuka, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Naoya Sakamoto, Toshiaki Ohteki, Toshifumi Hibi, Mamoru Watanabe. IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis. Eur J Immunol. 2009.10; 39 (10): 2737-2747. ( PubMed, DOI )

  84. Teruji Totsuka, Takanori Kanai, Yasuhiro Nemoto, Takayuki Tomita, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Naoya Sakamoto, Hisaya Akiba, Ko Okumura, Hideo Yagita, Mamoru Watanabe. RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis. J. Immunol.. 2009.05; 182 (10): 6079-6087. ( PubMed, DOI )

  85. Michio Onizawa, Takashi Nagaishi, Takanori Kanai, Ken-ichi Nagano, Shigeru Oshima, Yasuhiro Nemoto, Atsushi Yoshioka, Teruji Totsuka, Ryuichi Okamoto, Tetsuya Nakamura, Naoya Sakamoto, Kiichiro Tsuchiya, Kazuhiro Aoki, Keiichi Ohya, Hideo Yagita, Mamoru Watanabe. Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Am J Physiol Gastrointest Liver Physiol. 2009.04; 296 (4): G850-G859. ( PubMed, DOI )

  86. Minekazu Murayama, Ryuichi Okamoto, Kiichiro Tsuchiya, Junko Akiyama, Tetsuya Nakamura, Naoya Sakamoto, Takanori Kanai, Mamoru Watanabe. Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells. J. Gastroenterol.. 2009.03; 44 (3): 173-182. ( PubMed, DOI )

  87. Ryuichi Okamoto, Kiichiro Tsuchiya, Yasuhiro Nemoto, Junko Akiyama, Tetsuya Nakamura, Takanori Kanai, Mamoru Watanabe. Requirement of Notch activation during regeneration of the intestinal epithelia. Am J Physiol Gastrointest Liver Physiol. 2009.01; 296 (1): G23-G35. ( PubMed, DOI )

  88. Toshimitsu Fujii, Takayuki Tomita, Takanori Kanai, Yasuhiro Nemoto, Teruji Totsuka, Naoya Sakamoto, Tetsuya Nakamura, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe. FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow. Eur J Immunol. 2008.12; 38 (12): 3290-3303. ( PubMed, DOI )

  89. Takayuki Tomita, Takanori Kanai, Yasuhiro Nemoto, Toshimitsu Fujii, Kengo Nozaki, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Naoya Sakamoto, Teruji Totsuka, Mamoru Watanabe. Colitogenic CD4+ effector-memory T cells actively recirculate in chronic colitic mice. Inflamm. Bowel Dis.. 2008.12; 14 (12): 1630-1640. ( PubMed, DOI )

  90. 50. Akihiro Araki, Kiichiro Tsuchiya, Eriko Okada, Shinji Suzuki, Shigeru Oshima, Ryuichi Okamoto, Takanori Kanai, Mamoru Watanabe. Single-operator method for double-balloon endoscopy: a pilot study. Endoscopy. 2008.11; 40 (11): 936-938. ( PubMed, DOI )

  91. Yasuhiro Nemoto, Takanori Kanai, Shuji Tohda, Teruji Totsuka, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Naoya Sakamoto, Tetsuya Fukuda, Osamu Miura, Hideo Yagita, Mamoru Watanabe. Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis. Inflamm. Bowel Dis.. 2008.11; 14 (11): 1491-1503. ( PubMed, DOI )

  92. Atsushi Yoshioka, Ryuichi Okamoto, Shigeru Oshima, Junko Akiyama, Kiichiro Tsuchiya, Tetsuya Nakamura, Takanori Kanai, Mamoru Watanabe. Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells. Cytokine. 2008.10; 44 (1): 57-64. ( PubMed, DOI )

  93. Kimihiro Hino, Kiichiro Tsuchiya, Taro Fukao, Kotaro Kiga, Ryuichi Okamoto, Takanori Kanai, Mamoru Watanabe. Inducible expression of microRNA-194 is regulated by HNF-1alpha during intestinal epithelial cell differentiation. RNA. 2008.07; 14 (7): 1433-1442. ( PubMed, DOI )

  94. Teruji Totsuka, Takanori Kanai, Yasuhiro Nemoto, Takayuki Tomita, Kiichiro Tsuchiya, Naoya Sakamoto, Ryuichi Okamoto, Mamoru Watanabe. Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitis. Eur J Immunol. 2008.05; 38 (5): 1275-1286. ( PubMed, DOI )

  95. Takayuki Tomita, Takanori Kanai, Toshimitsu Fujii, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Teruji Totsuka, Naoya Sakamoto, Mamoru Watanabe. Continuous generation of colitogenic CD4(+) T cells in persistent colitis. Eur J Immunol. 2008.05; 38 (5): 1264-1274. ( PubMed, DOI )

  96. Takayuki Tomita, Takanori Kanai, Toshimitsu Fujii, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Teruji Totsuka, Naoya Sakamoto, Shizuo Akira, Mamoru Watanabe. MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis. J. Immunol.. 2008.04; 180 (8): 5291-5299. ( PubMed )

  97. Mikayo Aragaki, Kiichiro Tsuchiya, Ryuichi Okamoto, Sanae Yoshioka, Tetsuya Nakamura, Naoya Sakamoto, Takanori Kanai, Mamoru Watanabe. Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer. Biochem. Biophys. Res. Commun. 2008.04; 368 (4): 923-929. ( PubMed, DOI )

  98. Takayuki Tomita, Takanori Kanai, Yasuhiro Nemoto, Teruji Totsuka, Ryuichi Okamoto, Kiichiro Tsuchiya, Naoya Sakamoto, Mamoru Watanabe. Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis. J. Immunol.. 2008.01; 180 (1): 383-390. ( PubMed )

  99. Y Ito, T Kanai, T Totsuka, R Okamoto, K Tsuchiya, Y Nemoto, A Yoshioka, T Tomita, T Nagaishi, N Sakamoto, T Sakanishi, K Okumura, H Yagita, M Watanabe. Blockade of NKG2D signaling prevents the development of murine CD4+ T cell-mediated colitis. Am J Physiol Gastrointest Liver Physiol. 2008.01; 294 (1): G199-G207. ( PubMed, DOI )

  100. Teruji Totsuka, Takanori Kanai, Yasuhiro Nemoto, Shin Makita, Ryuichi Okamoto, Kiichiro Tsuchiya, Mamoru Watanabe. IL-7 Is essential for the development and the persistence of chronic colitis. J. Immunol.. 2007.04; 178 (8): 4737-4748. ( PubMed )

  101. Shin Makita, Takanori Kanai, Yasuhiro Nemoto, Teruji Totsuka, Ryuichi Okamoto, Kiichiro Tsuchiya, Masafumi Yamamoto, Hiroshi Kiyono, Mamoru Watanabe. Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation. J. Immunol.. 2007.04; 178 (8): 4937-4946. ( PubMed )

  102. Kiichiro Tsuchiya, Tetsuya Nakamura, Ryuichi Okamoto, Takanori Kanai, Mamoru Watanabe. Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer. Gastroenterology. 2007.01; 132 (1): 208-220. ( PubMed, DOI )

  103. Yasuhiro Nemoto, Takanori Kanai, Shin Makita, Ryuichi Okamoto, Teruji Totsuka, Kiyoshi Takeda, Mamoru Watanabe. Bone marrow retaining colitogenic CD4+ T cells may be a pathogenic reservoir for chronic colitis. Gastroenterology. 2007.01; 132 (1): 176-189. ( PubMed, DOI )

  104. R Fujii, T Kanai, Y Nemoto, S Makita, S Oshima, R Okamoto, K Tsuchiya, T Totsuka, M Watanabe. FTY720 suppresses CD4+CD44highCD62L- effector memory T cell-mediated colitis. Am J Physiol Gastrointest Liver Physiol. 2006.08; 291 (2): G267-G274. ( PubMed, DOI )

  105. Ryuichi Okamoto, Tomoko Matsumoto, Mamoru Watanabe. Regeneration of the intestinal epithelia: regulation of bone marrow-derived epithelial cell differentiation towards secretory lineage cells. Hum. Cell. 2006.05; 19 (2): 71-75. ( PubMed, DOI )

  106. Ryuichi Okamoto, Mamoru Watanabe. Cellular and molecular mechanisms of the epithelial repair in IBD. Dig. Dis. Sci.. 2005.10; 50 Suppl 1 S34-S38. ( PubMed, DOI )

  107. Teruji Totsuka, Takanori Kanai, Shin Makita, Rei Fujii, Yasuhiro Nemoto, Shigeru Oshima, Ryuichi Okamoto, Akemi Koyanagi, Hisaya Akiba, Ko Okumura, Hideo Yagita, Mamoru Watanabe. Regulation of murine chronic colitis by CD4+CD25- programmed death-1+ T cells. Eur J Immunol. 2005.06; 35 (6): 1773-1785. ( PubMed, DOI )

  108. Tomoko Matsumoto, Ryuichi Okamoto, Tomoharu Yajima, Takehiko Mori, Shinichiro Okamoto, Yasuo Ikeda, Makio Mukai, Motomi Yamazaki, Shigeru Oshima, Kiichiro Tsuchiya, Tetsuya Nakamura, Takanori Kanai, Hideyuki Okano, Johji Inazawa, Toshifumi Hibi, Mamoru Watanabe. Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine. Gastroenterology. 2005.06; 128 (7): 1851-1867. ( PubMed )

  109. Shin Namiki, Tetsuya Nakamura, Shigeru Oshima, Motomi Yamazaki, Yuko Sekine, Kiichiro Tsuchiya, Ryuichi Okamoto, Takanori Kanai, Mamoru Watanabe. IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome. FEBS Lett.. 2005.05; 579 (13): 2781-2787. ( PubMed, DOI )

  110. Eriko Okada, Motomi Yamazaki, Masanobu Tanabe, Tsutomu Takeuchi, Masanobu Nanno, Shigeru Oshima, Ryuichi Okamoto, Kiichiro Tsuchiya, Tetsuya Nakamura, Takanori Kanai, Toshifumi Hibi, Mamoru Watanabe. IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice. Am J Physiol Gastrointest Liver Physiol. 2005.04; 288 (4): G745-G754. ( PubMed, DOI )

  111. Shigeru Oshima, Tetsuya Nakamura, Shin Namiki, Eriko Okada, Kiichiro Tsuchiya, Ryuichi Okamoto, Motomi Yamazaki, Takanori Yokota, Masatoshi Aida, Yuki Yamaguchi, Takanori Kanai, Hiroshi Handa, Mamoru Watanabe. Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol. Cell. Biol.. 2004.07; 24 (14): 6298-6310. ( PubMed, DOI )

  112. Kenichi Ishii, Takanori Kanai, Teruji Totsuka, Koji Uraushihara, Takahiro Ishikura, Motomi Yamazaki, Ryuichi Okamoto, Akihiro Araki, Tatsuya Miyata, Katsuaki Tezuka, Tetsuya Nakamura, Mamoru Watanabe. Hyperexpression of inducible costimulator on lamina propria mononuclear cells in rat dextran sulfate sodium colitis. J. Gastroenterol. Hepatol.. 2004.02; 19 (2): 174-181. ( PubMed )

  113. Ryuichi Okamoto, Mamoru Watanabe. Molecular and clinical basis for the regeneration of human gastrointestinal epithelia. J. Gastroenterol.. 2004.01; 39 (1): 1-6. ( PubMed, DOI )

  114. Ryuichi Okamoto, Mamoru Watanabe. Prospects for regeneration of gastrointestinal epithelia with donor derived cells. Trends Mol Med. 2003.09; 9 (7): 286-290.

  115. Motomi Yamazaki, Tomoharu Yajima, Masanobu Tanabe, Kazuto Fukui, Eriko Okada, Ryuichi Okamoto, Shigeru Oshima, Tetsuya Nakamura, Takanori Kanai, Masahiro Uehira, Tsutomu Takeuchi, Hiromichi Ishikawa, Toshifumi Hibi, Mamoru Watanabe. Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis. J. Immunol.. 2003.08; 171 (3): 1556-1563. ( PubMed )

  116. Mamoru Watanabe, Motomi Yamazaki, Ryuichi Okamoto, Shinya Ohoka, Akihiro Araki, Tetsuya Nakamura, Takanori Kanai. Therapeutic approaches to chronic intestinal inflammation by specific targeting of mucosal IL-7/IL-7R signal pathway. Curr Drug Targets Inflamm Allergy. 2003.06; 2 (2): 119-123. ( PubMed )

  117. Teruji Totsuka, Takanori Kanai, Ryoichi Iiyama, Koji Uraushihara, Motomi Yamazaki, Ryuichi Okamoto, Toshifumi Hibi, Katsunari Tezuka, Miyuki Azuma, Hisaya Akiba, Hideo Yagita, Ko Okumura, Mamoru Watanabe. Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis. Gastroenterology. 2003.02; 124 (2): 410-421. ( PubMed, DOI )

  118. Ryuichi Okamoto, Tomoharu Yajima, Motomi Yamazaki, Takanori Kanai, Makio Mukai, Shinichiro Okamoto, Yasuo Ikeda, Toshifumi Hibi, Johji Inazawa, Mamoru Watanabe. Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract. Nat. Med.. 2002.09; 8 (9): 1011-1017. ( PubMed, DOI )

  119. Takanori Kanai, Mamoru Watanabe, Akira Okazawa, Toshiro Sato, Motomi Yamazaki, Susumu Okamoto, Hiromasa Ishii, Teruji Totsuka, Ryoichi Iiyama, Ryuichi Okamoto, Masao Ikeda, Masashi Kurimoto, Kiyoshi Takeda, Shizuo Akira, Toshifumi Hibi. Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease. Gastroenterology. 2001.10; 121 (4): 875-888. ( PubMed )

  120. Eri Oshina, Masanori Kobayashi, Ryuichi Okamoto. Functional Gallbladder Disorder: Characteristic Hepatobiliary Scintigraphy Findings. Intern Med. 2025.04; 64 (7): 1119-1120. ( PubMed, DOI )

  121. Ryosuke Hamamura, Masanori Kobayashi, Ryuichi Okamoto. Endoscopic transpapillary gallbladder drainage using a novel cholangioscope. Dig Endosc. 2025.04; 37 (4): 434-435. ( PubMed, DOI )

  122. Makoto Naganuma, Hisashi Shiga, Masayuki Shimoda, Minoru Matsuura, Kento Takenaka, Toshimitsu Fujii, Shojiro Yamamoto, Mao Matsubayashi, Taku Kobayashi, Nobuo Aoyama, Daisuke Saito, Kaoru Yokoyama, Kei Moriya, Kiichiro Tsuchiya, Shunsuke Shibui, Ami Kawamoto, Hiromichi Shimizu, Ryuichi Okamoto, Kazuki Sakamoto, Katsuki Yaguchi, Reiko Kunisaki, Shintaro Akiyama, Ryohei Hayashi, Keisuke Hasui, Shuji Kanmura, Shigeki Bamba, Yoshiyuki Mishima, Kazuki Kakimoto, Shinya Sugimoto, Atsushi Nakazawa, Takayuki Abe, Haruhiko Ogata, Tadakazu Hisamatsu, . First-line biologics as a treatment for ulcerative colitis: a multicenter randomized control study. J Gastroenterol. 2025.04; 60 (4): 430-441. ( PubMed, DOI )

  123. Hady Yuki Sugihara, Ryuichi Okamoto, Tomohiro Mizutani. Intestinal organoids: The path towards clinical application. Eur J Cell Biol. 2025.03; 104 (1): 151474. ( PubMed, DOI )

  124. Shintaro Akiyama, Hiromichi Shimizu, Akiko Tamura, Kaoru Yokoyama, Toshiyuki Sakurai, Mariko Kobayashi, Makoto Eizuka, Shunichi Yanai, Kei Nomura, Tomoyoshi Shibuya, Masahiro Takahara, Sakiko Hiraoka, Minako Sako, Atsushi Yoshida, Kozo Tsuruta, Shinichiro Yoshioka, Miki Koroku, Teppei Omori, Masayuki Saruta, Takayuki Matsumoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Toshimitsu Fujii. Comparative Efficacy and Safety of Three Janus Kinase Inhibitors in Ulcerative Colitis: A Real-World Multicentre Study in Japan. Aliment Pharmacol Ther. 2025.02; 61 (3): 524-537. ( PubMed, DOI )

  125. Jun Tsuchiya, Masato Miyoshi, Sei Kakinuma, Fukiko Kawai-Kitahata, Akihide Kamiya, Taro Shimizu, Ayako Sato, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Rion Kamimae, Shun Kaneko, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto. Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived Model. Cell Mol Gastroenterol Hepatol. 2025; 19 (2): 101422. ( PubMed, DOI )

  126. Miyako Murakawa, Mina Nakagawa, Hisaaki Nishimura, Shun Kaneko, Masato Miyoshi, Fukiko Kawai-Kitahata, Sayuri Nitta, Jun Tsuchiya, Taro Shimizu, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Yasuhiro Iizuka, Hideki Sakai, Yuki Sakurai, Ayako Sato, Seishin Azuma, Takahiro Kawamura, Chiaki Maeyashiki, Masayuki Kurosaki, Fumihiko Kusano, Hideki Watanabe, Hitoshi Kurata, Yuko Karakama, Takeo Fujiwara, Yuki Nagata, Toshihiro Tanaka, Sei Kakinuma, Ryuichi Okamoto, Yasuhiro Asahina. High serum gamma-glutamyltransferase level after hepatitis C virus elimination is a risk factor for the development of hepatocellular carcinoma. Hepatol Res. 2024.12; 54 (12): 1128-1138. ( PubMed, DOI )

  127. Kento Takenaka, Tadakazu Hisamatsu, Taku Kobayashi, Hironori Yamamoto, Naoki Ohmiya, Ryohei Hayashi, Katsuyoshi Matsuoka, Masayuki Saruta, Akira Andoh, Norimasa Fukata, Kenji Watanabe, Hiroyuki Imaeda, Fumihito Hirai, Takayuki Matsumoto, Akihiro Hirakawa, Tomonori Yano, Minoru Matsuura, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe. Inadequate Efficacy of Biologics for Treating Proximal Ileal Lesions in Crohn's Disease; A Prospective Multicenter Study. Clin Gastroenterol Hepatol. 2024.12; Online ahead of print ( PubMed, DOI )

  128. Ryo Morikawa, Kentaro Nitta, Shuntaro Yasuda, Yoshihito Kano, Rika Noji, Satoru Aoyama, Shingo Sato, Sadakatsu Ikeda, Ryuichi Okamoto, Masashi Nagata, Takehiko Mori, Mitsukuni Suenaga. Identification of risk factors for gastrointestinal immune-related adverse events associated with immune check point inhibitors. Expert Opin Drug Saf. 2024.12; 1-8. ( PubMed, DOI )

  129. Junichi Takahashi, Hady Yuki Sugihara, Shu Kato, Sho Kawasaki, Sayaka Nagata, Ryuichi Okamoto, Tomohiro Mizutani. Controlled aggregative assembly to form self-organizing macroscopic human intestine from induced pluripotent stem cells. Cell Rep Methods. 2024.12; 4 (12): 100930. ( PubMed, DOI )

  130. Hiromune Katsuda, Masanori Kobayashi, Go Ito, Ami Kawamoto, Susumu Krimura, Hiroyuki Sato, Akihiro Hirakawa, Keiichi Akahoshi, Atsushi Kudo, Kazuo Ohtsuka, Ryuichi Okamoto. Evaluating endoscopic ultrasound-guided tissue acquisition for diagnosis of small pancreatic neuroendocrine neoplasms. Endosc Int Open. 2024.11; 12 (11): E1379-E1385. ( PubMed, DOI )

  131. Shun Ishido, Masanori Kobayashi, Ryuichi Okamoto. Low-cost and reliable method for confirming residual bile duct stones utilizing a novel peroral cholangioscope. Dig Endosc. 2024.10; 36 (10): 1173-1175. ( PubMed, DOI )

  132. Watakabe K, Miyoshi M, Kakinuma S, Sato A, Tsuchiya J, Shimizu T, Mochida T, Inada K, Kaneko S, Kawai-Kitahata F, Murakawa M, Nitta S, Nakagawa M, Oshima S, Watanabe M, Ma A, Asahina Y, Okamoto R. A20 in hepatic stellate cells suppresses chronic hepatitis by inhibiting DCLK1-JNK pathway-dependent chemokines. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2024.07; 38 (13): e23757. ( PubMed, DOI )

  133. Masanori Kobayashi, Mao Niimi, Hiromune Katsuda, Keiichi Akahoshi, Yuko Kinowaki, Masanao Sasaki, Akihiro Hirakawa, Ukihide Tateishi, Minoru Tanabe, Ryuichi Okamoto. Optimization of Endoscopic Ultrasound Characteristics in the Diagnosis of Malignant Intraductal Papillary Mucinous Neoplasm. Pancreas. 2024.07; 53 (6): e521-e527. ( PubMed, DOI )

  134. Kazuma Saito, Masanori Kobayashi, Minato Yokoyama, Towako Taguchi, Koichiro Kimura, Takumi Akashi, Yasuhisa Fujii, Ryuichi Okamoto. Transjejunal fine-needle biopsy using a forward-viewing echoendoscope for diagnosis of a rare hereditary paraganglioma. VideoGIE. 2024.07; 9 (7): 329-332. ( PubMed, DOI )

  135. Shintaro Akiyama, Kaoru Yokoyama, Soichi Yagi, Shinichiro Shinzaki, Kozo Tsuruta, Shinichiro Yoshioka, Minako Sako, Hiromichi Shimizu, Mariko Kobayashi, Toshiyuki Sakurai, Kei Nomura, Tomoyoshi Shibuya, Masahiro Takahara, Sakiko Hiraoka, Kyohei Sugai, Shunichi Yanai, Atsushi Yoshida, Miki Koroku, Teppei Omori, Masayuki Saruta, Takayuki Matsumoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Toshimitsu Fujii. Efficacy and safety of filgotinib for ulcerative colitis: A real-world multicenter retrospective study in Japan. Aliment Pharmacol Ther. 2024.06; 59 (11): 1413-1424. ( PubMed, DOI )

  136. Keito Suzuki, Yutaka Yasui, Kaoru Tsuchiya, Hiroaki Matsumoto, Yudai Yamazaki, Naoki Uchihara, Yuki Tanaka, Haruka Miyamoto, Michiko Yamada-Shimizu, Taisei Keitoku, Risa Okada, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Nobuharu Tamaki, Hiroyuki Nakanishi, Yuka Takahashi, Yasuhiro Asahina, Ryuichi Okamoto, Masayuki Kurosaki, Namiki Izumi. Impact of immune-related adverse events in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab. J Gastroenterol Hepatol. 2024.06; 39 (6): 1183-1189. ( PubMed, DOI )

  137. Hiromune Katsuda, Masanori Kobayashi, Ryuichi Okamoto. Endoscopic recanalization of an occluded Braun anastomosis using an endoscopic injection needle. Dig Endosc. 2024.05; Online ahead of print ( PubMed, DOI )

  138. Nobuhiko Ogasawara, Yoshihito Kano, Yosuke Yoneyama, Sakurako Kobayashi, Satoshi Watanabe, Sakura Kirino, Fausto D Velez-Bravo, Yourae Hong, Aleksandra Ostapiuk, Pavlo Lutsik, Iichiroh Onishi, Shinichi Yamauchi, Yui Hiraguri, Go Ito, Yusuke Kinugasa, Kenichi Ohashi, Mamoru Watanabe, Ryuichi Okamoto, Sabine Tejpar, Shiro Yui. Discovery of non-genomic drivers of YAP signaling modulating the cell plasticity in CRC tumor lines. iScience. 2024.03; 27 (3): 109247. ( PubMed, DOI )

  139. Tatsuya Suzuki, Yuka Hayakawa, Shun Kaneko, Kento Takenaka, Keiya Watakabe, Yuko Kinowaki, Akira Takemoto, Kazuo Ohtsuka, Yasuhiro Asahina, Ryuichi Okamoto. Granulomatous hepatitis with Crohn's disease: a case report. Clin J Gastroenterol. 2024.03; Online ahead of print ( PubMed, DOI )

  140. Shun Fujiwara, Yoshihito Kano, Yasuhiro Maejima, Tomoyuki Fujioka, Kazuhiro Tamura, Susumu Kirimura, Satoshi Miyake, Ryuichi Okamoto. Clinical Response of Primary Malignant Pericardial Mesothelioma with Peritoneal Dissemination to Nivolumab. Intern Med. 2024.02; 63 (4): 513-519. ( PubMed, DOI )

  141. Miwa Himuro, Yuka Wakabayashi, Tomomi Taguchi, Takehiro Katahira, Luka Suzuki, Hitoshi Iida, Takeshi Ogihara, Yuya Nishida, Shugo Sasaki, Francis C Lynn, Yuichi Hiraoka, Shigeru Oshima, Ryuichi Okamoto, Yoshio Fujitani, Hirotaka Watada, Takeshi Miyatsuka. Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation. Diabetologia. 2024.01; 67 (1): 156-169. ( PubMed, DOI )

  142. Yuki Yonemoto, Yasuhiro Nemoto, Ryo Morikawa, Nana Shibayama, Shigeru Oshima, Takashi Nagaishi, Tomohiro Mizutani, Go Ito, Satoru Fujii, Ryuichi Okamoto. T cell subsets were increased in the small intestinal intraepithelial lymphocytes of aged mice. Front Immunol. 2024.01; 15 1340048. ( PubMed, DOI )

  143. Shun Kaneko, Yasuhiro Asahina, Miyako Murakawa, Seishin Azuma, Kento Inada, Tomohiro Mochida, Keiya Watakabe, Taro Shimizu, Jun Tsuchiya, Masato Miyoshi, Fukiko Kawai-Kitahata, Sayuri Nitta, Marie Takahashi, Tomoyuki Fujioka, Mitsuhiro Kishino, Tatsuhiko Anzai, Sei Kakinuma, Mina Nakagawa, Ryuichi Okamoto. Analysis of prognosis and background liver disease in non-advanced hepatocellular carcinoma in two decades. PLoS One. 2024; 19 (3): e0297882. ( PubMed, DOI )

  144. Masanori Kobayashi, Hiromune Katsuda, Aya Maekawa, Keiichi Akahoshi, Ryosuke Watanabe, Yuko Kinowaki, Hisaaki Nishimura, Takeo Fujiwara, Minoru Tanabe, Ryuichi Okamoto. Development of an intraductal papillary mucinous neoplasm malignancy prediction scoring system. PLoS One. 2024; 19 (10): e0312234. ( PubMed, DOI )

  145. Nanako Hashido, Masanori Kobayashi, Ami Kawamoto, Suguru Mabuchi, Hiromune Katsuda, Kazuo Ohtsuka, Yasuhiro Asahina, Masayoshi Hashimoto, Ryuichi Okamoto. Sphincter of Oddi dysfunction that could not be diagnosed with Rome IV: a case report. Clin J Gastroenterol. 2023.12; 16 (6): 913-918. ( PubMed, DOI )

  146. Shun Kaneko, Yasuhiro Asahina, Miyako Murakawa, Shunsuke Ueyama, Chiaki Maeyashiki, Hideki Watanabe, Akiko Kusano-Kitazume, Ayako Sato, Kozue Uchidate, Takehito Asakawa, Sho Watanabe, Yasuhiro Iizuka, Isamu Shibata, Shinya Oooka, Yuko Karakama, Takashi Fujii, Taro Watabe, Keiichi Akahoshi, Minoru Tanabe, Kento Inada, Tomohiro Mochida, Keiya Watakabe, Taro Shimizu, Jun Tsuchiya, Masato Miyoshi, Fukiko Kitahata-Kawai, Sayuri Nitta, Mina Nakagawa, Sei Kakinuma, Ryuichi Okamoto, . Prognostic Significance of C-Reactive Protein in Unresectable Hepatocellular Carcinoma treated with Atezolizumab and Bevacizumab. Hepatol Res. 2023.12; Online ahead of print. ( PubMed, DOI )

  147. Tharathorn Suwatthanarak, Pariyada Tanjak, Thanawat Suwatthanarak, Onchira Acharayothin, Kullanist Thanormjit, Amphun Chaiboonchoe, Thikhamporn Tawantanakorn, Chainarong Phalanusitthepha, Atthaphorn Trakarnsanga, Asada Methasate, Manop Pithukpakorn, Ryuichi Okamoto, Vitoon Chinswangwatanakul. Exploring extracellular matrix and prostaglandin pathway alterations across varying resection margin distances of right-sided colonic adenocarcinoma. BMC Cancer. 2023.12; 23 (1): 1202. ( PubMed, DOI )

  148. Ami Kawamoto, Kento Takenaka, Shuji Hibiya, Yoshio Kitazume, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Kazuo Ohtsuka, Ryuichi Okamoto. Combination of leucine-rich alpha-2 glycoprotein and fecal markers detect Crohn's disease activity confirmed by balloon-assisted enteroscopy. Intest Res. 2023.11; Online ahead of print ( PubMed, DOI )

  149. Shuji Hibiya, Takashi Fujii, Toshimitsu Fujii, Shinji Suzuki, Mayumi Kondo, Shinya Ooka, Yohei Furumoto, Seishin Azuma, Kei Tanaka, Hitoshi Kurata, Shohei Tanaka, Masayuki Kurosaki, Kazuyoshi Nagayama, Fumihiko Kusano, Yasuhiro Iizuka, Takahiro Kawamura, Hidekazu Ikemiyagi, Shinya Sakita, Tsunehito Yauchi, Hideki Watanabe, Ami Kawamoto, Yusuke Matsuyama, Kazuo Ohtsuka, Ryuichi Okamoto. COVID-19 severity is associated with the risk of gastrointestinal bleeding. BMJ Open Gastroenterol. 2023.11; 10 (1): ( PubMed, DOI )

  150. Masanori Kobayashi, Hiromune Katsuda, Kazuo Ohtsuka, Ryuichi Okamoto. Comparison of guidewires for successful cannulation of biliary stenosis and targeting of biliary branches in ERCP. Endosc Int Open. 2023.09; 11 (9): E805-E810. ( PubMed, DOI )

  151. Kirino Sakura, Tamaki Nobuharu, Kurosaki Masayuki, Takahashi Yuka, Higuchi Mayu, Itakura Yoshie, Tanaka Yuki, Inada Kento, Ishido Shun, Yamashita Koji, Nobusawa Tsubasa, Matsumoto Hiroaki, Hayakawa Yuka, Kakegawa Tatsuya, Takaura Kenta, Tanaka Shohei, Maeyashiki Chiaki, Kaneko Shun, Yasui Yutaka, Tsuchiya Kaoru, Nakanishi Hiroyuki, Okamoto Ryuichi, Izumi Namiki. Detecting advanced liver fibrosis using ultrasound shear wave velocity measurement in the general population QUANTITATIVE IMAGING IN MEDICINE AND SURGERY. 2023.08; 13 (10): 6493-6502. ( PubMed, DOI )

  152. Takayuki Yamamoto, Hiroshi Nakase, Kenji Watanabe, Shinichiro Shinzaki, Noritaka Takatsu, Toshimitsu Fujii, Ryuichi Okamoto, Katsuyoshi Matsuoka, Akihiro Yamada, Reiko Kunisaki, Minoru Matsuura, Hisashi Shiga, Shigeki Bamba, Yohei Mikami, Takahiro Shimoyama, Satoshi Motoya, Takehiro Torisu, Taku Kobayashi, Naoki Ohmiya, Masayuki Saruta, Koichiro Matsuda, Takayuki Matsumoto, Atsuo Maemoto, Yoko Murata, Shinichi Yoshigoe, Shinya Nagasaka, Tsutomu Yajima, Tadakazu Hisamatsu, . Diagnosis and Clinical Features of Perianal Lesions in Newly Diagnosed Crohn's Disease: Subgroup Analysis from Inception Cohort Registry Study of Patients with Crohn's Disease (iCREST-CD). J Crohns Colitis. 2023.08; 17 (8): 1193-1206. ( PubMed, DOI )

  153. Kentaro Miyamoto, Tomohisa Sujino, Yosuke Harada, Hiroshi Ashida, Yusuke Yoshimatsu, Yuki Yonemoto, Yasuhiro Nemoto, Michio Tomura, Hassan Melhem, Jan Hendrik Niess, Toshihiko Suzuki, Toru Suzuki, Shohei Suzuki, Yuzo Koda, Ryuichi Okamoto, Yohei Mikami, Toshiaki Teratani, Kenji F. Tanaka, Akihiko Yoshimura, Toshiro Sato, Takanori Kanai. The gut microbiota-induced kynurenic acid recruits GPR35-positive macrophages to promote experimental encephalitis. Cell Rep. 2023.08; 42 (8): 113005. ( PubMed, DOI )

  154. Morimoto K, Ueda H, Asano D, Ishikawa Y, Watanabe S, Akahoshi K, Ono H, Kobayashi M, Okamoto R, Tanaka S, Tanabe M. Incidence and Mechanism of Refractory Postoperative Cholangitis After Hepatectomy with Hepaticojejunostomy. J Gastrointest Surg. 2023.08; 27 (8): 1668-1676. ( PubMed, DOI )

  155. Junichi Takahashi, Hady Yuki Sugihara, Shu Kato, Sayaka Nagata, Ryuichi Okamoto, Tomohiro Mizutani. Protocol to generate large human intestinal organoids using a rotating bioreactor. STAR Protocols. 2023.06; 4 (3): 102374. ( PubMed, DOI )

  156. Katsuyoshi Matsuoka, Toshimitsu Fujii, Ryuichi Okamoto, Akihiro Yamada, Reiko Kunisaki, Minoru Matsuura, Kenji Watanabe, Hisashi Shiga, Noritaka Takatsu, Shigeki Bamba, Yohei Mikami, Takayuki Yamamoto, Takahiro Shimoyama, Satoshi Motoya, Takehiro Torisu, Taku Kobayashi, Naoki Ohmiya, Masayuki Saruta, Koichiro Matsuda, Takayuki Matsumoto, Hiroshi Nakase, Atsuo Maemoto, Shinichiro Shinzaki, Yoko Murata, Shinichi Yoshigoe, Ayako Sasaki, Tsutomu Yajima, Tadakazu Hisamatsu, . Correction: Characteristics of adult patients newly diagnosed with Crohn's disease: interim analysis of the nation-wide inception cohort registry study of patients with Crohn's disease in Japan (iCREST-CD). J Gastroenterol. 2023.06; 58 (6): 602-603. ( PubMed, DOI )

  157. Kento Takenaka, Ami Kawamoto, Yoshio Kitazume, Toshimitsu Fujii, Yumi Udagawa, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto. Transmural Remission Characterized by High Biologic Concentrations Demonstrates Better Prognosis in Crohn's Disease. J Crohns Colitis. 2023.06; 17 (6): 855-862. ( PubMed, DOI )

  158. Kento Takenaka, Yoshio Kitazume, Ami Kawamoto, Toshimitsu Fujii, Yumi Udagawa, Ryosuke Wanatabe, Hiromichi Shimizu, Shuji Hibiya, Masakazu Nagahori, Kazuo Ohtsuka, Hiroyuki Sato, Akihiro Hirakawa, Mamoru Watanabe, Ryuichi Okamoto. Serum Leucine-Rich α2 Glycoprotein: A Novel Biomarker for Transmural Inflammation in Crohn's Disease. Am J Gastroenterol. 2023.06; 118 (6): 1028-1035. ( PubMed, DOI )

  159. Yuka Hayakawa, Nobuharu Tamaki, Hiroyuki Nakanishi, Masayuki Kurosaki, Yuki Tanaka, Kento Inada, Shun Ishido, Sakura Kirino, Koji Yamashita, Tsubasa Nobusawa, Hiroaki Matsumoto, Tatsuya Kakegawa, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Shun Kaneko, Yutaka Yasui, Yuka Takahashi, Kaoru Tsuchiya, Ryuichi Okamoto, Namiki Izumi. Add-on Therapeutic Effects of Rifaximin on Treatment-resistant Hepatic Encephalopathy. Internal Medicine. 2023.04; 62 (7): 973-978. ( PubMed, DOI )

  160. Fujiwara S, Kawamoto A, Motobayashi M, Hibiya S, Takenaka K, Shimizu H, Saito E, Fujii T, Nagahori M, Kawata D, Umezawa N, Hosoya T, Yasuda S, Ohtsuka K, Okamoto R. Hemorrhagic gastric ulcer in a patient with Behcet's disease successfully treated with infliximab. DEN open. 2023.04; 3 (1): e196. ( PubMed, DOI )

  161. Taisei Keitoku, Nobuharu Tamaki, Masayuki Kurosaki, Kento Inada, Sakura Kirino, Naoki Uchihara, Keito Suzuki, Yuki Tanaka, Haruka Miyamoto, Shun Ishido, Michiko Yamada, Tsubasa Nobusawa, Hiroaki Matsumoto, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Shun Kaneko, Yutaka Yasui, Yuka Takahashi, Kaoru Tsuchiya, Hiroyuki Nakanishi, Yasuhiro Asahina, Ryuichi Okamoto, Namiki Izumi. Effect of fatty liver and fibrosis on hepatocellular carcinoma development in patients with chronic hepatitis B who received nucleic acid analog therapy. J Viral Hepat. 2023.04; 30 (4): 297-302. ( PubMed, DOI )

  162. Satoshi Watanabe, Nobuhiko Ogasawara, Sakurako Kobayashi, Sakura Kirino, Masami Inoue, Yui Hiraguri, Sayaka Nagata, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Yasuhiro Nemoto, Kiichiro Tsuchiya, Ryuichi Okamoto, Mamoru Watanabe, Shiro Yui. Organoids transplantation as a new modality to design epithelial signature to create a membrane-protective sulfomucin-enriched segment. J Gastroenterol. 2023.04; 58 (4): 379-393. ( PubMed, DOI )

  163. Mina Nakagawa, Yasuhiro Asahina, Sei Kakinuma, Ryuichi Okamoto. Impact of eradication of hepatitis C virus on liver-related and -unrelated diseases: morbidity and mortality of chronic hepatitis C after SVR. J Gastroenterol. 2023.04; 58 (4): 299-310. ( PubMed, DOI )

  164. Daiki Yamada, Yudai Kojima, Akinori Hosoya, Masahiro Suzuki, Taro Watabe, Tadahiko Inoue, Naoya Tsugawa, Takehito Asakawa, Yuki Yonemoto, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Motoyuki Shimonaka, Keiji Kuba, Junji Ishida, Akiyoshi Fukamizu, Josef M Penninger, Mamoru Watanabe, Ryuichi Okamoto, Takashi Nagaishi. Apelin expression is downregulated in T cells in a murine model of chronic colitis. Biochem Biophys Res Commun. 2023.03; 647 72-79. ( PubMed, DOI )

  165. Eiko Saito, Kazuo Ohtsuka, Ami Kawamoto, Toshimitsu Fujii, Kento Takenaka, Shuji Hibiya, Hiromichi Shimizu, Masakazu Nagahori, Shohei Tomii, Ryuichi Okamoto. A case of venous stasis colitis possibly caused by eplerenone. Clin J Gastroenterol. 2023.02; 16 (1): 69-72. ( PubMed, DOI )

  166. Shun Kaneko, Yasuhiro Asahina, Mina Nakagawa, Miyako Murakawa, Yasunari Miyazaki, Takahiro Asakage, Shohei Fukuda, Takeshi Namiki, Yoshito Kano, Masashi Nagata, Jun Tsuchiya, Masato Miyoshi, Fukiko Kitahata-Kawai, Sayuri Nitta, Yasuhiro Itsui, Sei Kakinuma, Ryuichi Okamoto. Factors associated with liver injury and prognosis in advanced cancer patients treated with immune checkpoint inhibitors. Hepatol Res. 2023.01; ( PubMed, DOI )

  167. Shun Ishido, Kaoru Tsuchiya, Yoshihito Kano, Yutaka Yasui, Kenta Takaura, Naoki Uchihara, Keito Suzuki, Yuki Tanaka, Haruka Miyamoto, Michiko Yamada, Hiroaki Matsumoto, Tsubasa Nobusawa, Taisei Keitoku, Shohei Tanaka, Chiaki Maeyashiki, Nobuharu Tamaki, Yuka Takahashi, Hiroyuki Nakanishi, Urara Sakurai, Yasuhiro Asahina, Ryuichi Okamoto, Masayuki Kurosaki, Namiki Izumi. Clinical Utility of Comprehensive Genomic Profiling in Patients with Unresectable Hepatocellular Carcinoma. Cancers (Basel). 2023.01; 15 (3): 719. ( PubMed, DOI )

  168. Ryuichi Okamoto, Tomohiro Mizutani, Hiromichi Shimizu. Development and Application of Regenerative Medicine in Inflammatory Bowel Disease. Digestion. 2023; 104 (1): 24-29. ( PubMed, DOI )

  169. Takahashi J, Mizutani T, Sugihara HY, Nagata S, Kato S, Hiraguri Y, Takeoka S, Tsuchiya M, Kuno R, Kakinuma S, Watanabe M, Okamoto R. Suspension culture in a rotating bioreactor for efficient generation of human intestinal organoids. Cell Reports Methods. 2022.11; 2 (11): 100337. ( PubMed, DOI )

  170. Katsuyoshi Matsuoka, Toshimitsu Fujii, Ryuichi Okamoto, Akihiro Yamada, Reiko Kunisaki, Minoru Matsuura, Kenji Watanabe, Hisashi Shiga, Noritaka Takatsu, Shigeki Bamba, Yohei Mikami, Takayuki Yamamoto, Takahiro Shimoyama, Satoshi Motoya, Takehiro Torisu, Taku Kobayashi, Naoki Ohmiya, Masayuki Saruta, Koichiro Matsuda, Takayuki Matsumoto, Hiroshi Nakase, Atsuo Maemoto, Shinichiro Shinzaki, Yoko Murata, Shinichi Yoshigoe, Ayako Sasaki, Tsutomu Yajima, Tadakazu Hisamatsu. Characteristics of adult patients newly diagnosed with Crohn's disease: interim analysis of the nation-wide inception cohort registry study of patients with Crohn's disease in Japan (iCREST-CD). J Gastroenterol. 2022.11; 57 (11): 867-878. ( PubMed, DOI )

  171. Sakurako Kobayashi, Nobuhiko Ogasawara, Satoshi Watanabe, Yosuke Yoneyama, Sakura Kirino, Yui Hiraguri, Masami Inoue, Sayaka Nagata, Yoshimi Okamoto-Uchida, Satoshi Kofuji, Hiromichi Shimizu, Go Ito, Tomohiro Mizutani, Shinichi Yamauchi, Yusuke Kinugasa, Yoshihito Kano, Yasuhiro Nemoto, Mamoru Watanabe, Kiichiro Tsuchiya, Hiroshi Nishina, Ryuichi Okamoto, Shiro Yui. Collagen type I-mediated mechanotransduction controls epithelial cell fate conversion during intestinal inflammation. Inflamm Regen. 2022.11; 42 (1): 49. ( PubMed, DOI )

  172. Kirino Sakura, Tamaki Nobuharu, Kurosaki Masayuki, Kaneko Shun, Inada Kento, Tanaka Yuki, Ishido Shun, Yamashita Koji, Nobusawa Tsubasa, Matsumoto Hiroaki, Hayakawa Yuka, Kakegawa Tatsuya, Higuchi Mayu, Takaura Kenta, Tanaka Shohei, Maeyashiki Chiaki, Yasui Yutaka, Takahashi Yuka, Tsuchiya Kaoru, Nakanishi Hiroyuki, Okamoto Ryuichi, Izumi Namiki. Alanine aminotransferase levels as therapeutic targets after nucleotide/nucleoside analog therapy in patient with chronic hepatitis B HEPATOLOGY RESEARCH. 2022.10; 53 (1): 35-42. ( PubMed, DOI )

  173. Hiromichi Shimizu, Toshimitsu Fujii, Kenji Kinoshita, Ami Kawamoto, Shuji Hibiya, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto. Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus. BMC Gastroenterol. 2021.12; 21 (1): 494. ( PubMed, DOI )

  174. 岡本 隆一, 水谷 知裕, 藤井 悟, 清水 寛路. 細胞を用いた再生医療の現状と今後の展望 臨床への展開(Vol.13) 炎症性腸疾患と再生医療 医学のあゆみ. 2025.03; 292 (11): 924-928. ( DOI )

  175. 日比谷 秀爾, 大塚 和朗, 岡本 隆一. 治療法の再整理とアップデートのために 専門家による私の治療 小腸腫瘍 日本医事新報. 2025.01; (5255): 46-47.

  176. 竹中 健人, 河本 亜美, 日比谷 秀爾, 大塚 和朗, 岡本 隆一. 小腸疾患に対する最新の内視鏡臨床、バルーン内視鏡を用いたクローン病モニタリング 臨牀消化器内科. 2024.11; 39 (12): 1529-1536.

  177. 田村 皓子, 岡本 隆一. 特集：炎症性腸疾患_5-ASA不耐と診断し、ステロイドや分子標的薬の導入を回避し得た潰瘍性大腸炎の一例 Medical Practice. 2024.11; 41 (11): 1748-1751.

  178. 小室 一成, 長沼 誠, 鈴木 康夫, 岡本 隆一. 【炎症性腸疾患 躍進の時代を迎えた炎症性腸疾患診療】躍進の時代における炎症性腸疾患診療の実際と課題 Medical Practice. 2024.11; 41 (11): 1614-1625.

  179. 岡本 隆一. 【今この研究が面白い!】(第6章)消化管 炎症性腸疾患 オルガノイドシステムを利用した難治性炎症性腸疾患の再生医療 内科. 2024.09; 134 (3): 586-589. ( DOI )

  180. 福田 将義, 早川 優香, 大塚 和朗, 岡本 隆一. 【十二指腸・小腸疾患アトラス】腫瘍, 腫瘍様病変 粘膜下腫瘍/粘膜下腫瘍様病変 脂肪腫 消化器内視鏡. 2024.04; 36 (4): 500-501. ( DOI )

  181. 岡本 隆一, 水谷 知裕, 藤井 悟, 清水 寛路. 特集「多角化するIBD診療の最適化に向けて」炎症性腸疾患と再生医療 Medical Science Digest. 2024.03; 50 (3):

  182. 岡本 隆一, 水谷 知裕, 清水 寛路. 【オルガノイドがもたらすライフサイエンス革命　あなたの研究に、どう使う?進化と深化を生む未来型研究30選】(第3章)オルガノイド生命医科学研究が生み出す新領域の萌芽　オルガノイドを利用した消化器領域の再生医療の開発 実験医学. 2024.03; 42 (5): 826-831.

  183. 清水 寛路, 水谷 知裕, 岡本 隆一. 【感染症を鑑別したあとは？非感染性腸炎を見極める！】炎症性腸疾患治療の最新情報 大腸オルガノイド移植療法の実際 診断と治療. 2024.03; 112 (3): 369-372. ( DOI )

  184. 岡本 隆一, 水谷 知裕, 藤井 悟, 清水 寛路. 患者まで届いている再生医療　潰瘍性大腸炎に対する自家腸上皮オルガノイド移植 再生医療. 2024.02; 23 (1): 038-043.

  185. 勝又 理沙, 金子 俊, 小林 正典, 中川 美奈, 勝田 景統, 加藤 祐己, 桐村 進, 大塚 和朗, 朝比奈 靖浩, 岡本 隆一. 経口胆道鏡にて診断しえた再発肝細胞癌の１例 日本消化器内視鏡学会雑誌. 2023.12; 65 (12): 2413-2420.

  186. 岡本 隆一, 水谷 知裕, 清水 寛路. 【消化器領域における再生医療の現状と展望】オルガノイド治療 日本消化器病学会雑誌. 2023.12; 120 (12): 964-972.

  187. 藤井 俊光, 岡本 隆一. 【炎症性腸疾患に対する検査法の進歩】Cross-sectional imagingとしてのMRIとtransmural healing 日本消化器病学会雑誌. 2023.11; 120 (11): 888-897. ( PubMed, DOI )

  188. 竹中 健人, 藤井 俊光, 大塚 和朗, 岡本 隆一. 【小腸画像診断のトピックス】MR enterography 胃と腸. 2023.11; 58 (11): 1491-1498. ( DOI )

  189. 大塚 和朗, 竹中 健人, 日比谷 秀爾, 河本 亜美, 齊藤 詠子, 田村 皓子, 張 肇豐, 岡本 隆一. 【小腸画像診断のトピックス】新しい小腸画像診断のトピックス 像強調観察 シングルバルーン内視鏡(NBI,TXI,RDI) 胃と腸. 2023.11; 58 (11): 1531-1536.

  190. 永石 宇司, 井上 忠彦, 伏見 萌音, 山田 大貴, 岡本 隆一, 安達 貴弘. 【腸管IgAの最先端～明らかになりつつあるIgAによる腸管微生物叢制御機構とその重要性～】IgAによる回腸免疫恒常性の維持 消化器病学サイエンス. 2023.06; 7 (2): 86-89.

  191. 栗原 正道, 江川 隆英, 小林 正典, 大塚 和朗, 渡邊 秀一, 赤星 径一, 田邉 稔, 岡本 隆一. 金属ステント留置後の繰り返す逆行性胆管炎に対してダックビル型逆流防止金属ステントが奏効した1例 Gastroenterological Endoscopy. 2023.04; 65 (4): 368-374. ( DOI 医中誌 )

  192. 岡本 隆一. 潰瘍性大腸炎　新しい治療の展開 SRL宝函. 2023.04; 44 (1): 26-33. ( 医中誌 )

  193. 大塚 和朗, 竹中 健人, 日比谷 秀爾, 河本 亜美, 齊藤 詠子, 岡本 隆一. 【進化し続けるIEE】IEEを使いこなす 小腸内視鏡/カプセル内視鏡 バルーン内視鏡 IEEをどう活用するか 消化器内視鏡. 2023.03; 35 (3): 369-372. ( DOI 医中誌 )

  194. 岡本 隆一, 水谷 知裕, 清水 寛路. 【真の実臨床応用をめざした再生医療2023　リバーストランスレーショナルリサーチのいまと産業化のための技術開発】(第3章)新規の細胞,組織の再生技術,疾患モデル作成　腸上皮オルガノイドを用いた炎症性腸疾患に対する治療 実験医学. 2023.02; 41 (2): 258-262. ( 医中誌 )

  195. 岡本 隆一. 【消化管疾患update】炎症性腸疾患　基礎と臨床における話題 BIO Clinica. 2023.01; 38 (1): 16-20. ( 医中誌 )

  196. 岡本 隆一, 水谷 知裕, 清水 寛路. 【多角的アプローチによる炎症性腸疾患の最新治療】幹細胞からみた炎症性腸疾患の病態と治療 日本消化器病学会雑誌. 2023; 120 (7): 562-570. ( PubMed, DOI )

  197. 岡本 隆一, 水谷 知裕, 清水 寛路. 【再生医療の現状と未来】炎症性腸疾患に対する粘膜再生医療 日本医師会雑誌. 2022.07; 151 (4): 592. ( 医中誌 )

  198. 大塚 和朗, 竹中 健人, 日比谷 秀爾, 福田 将義, 岡本 隆一. 【内視鏡データリファレンスブック2022】臓器別　十二指腸・小腸　小腸腫瘍 消化器内視鏡. 2022.04; 34 (4): 678-682. ( 医中誌 )

  199. 高橋 純一, 岡本 隆一. 治療法の再整理とアップデートのために　専門家による私の治療　顕微鏡的大腸炎 日本医事新報. 2022.04; (5110): 39-40. ( 医中誌 )

  200. 藤井 俊光, 日比谷 秀爾, 岡本 隆一, 渡辺 守. 【炎症性腸疾患update-診断・治療の最新知見-】炎症性腸疾患の治療　薬物治療　5-ASA製剤 日本臨床. 2022.03; 80 (3): 433-438. ( 医中誌 )

  201. 岡本 隆一, 水谷 知裕, 清水 寛路. 【炎症性腸疾患update-診断・治療の最新知見-】炎症性腸疾患における再生医療の現状と展望 日本臨床. 2022.03; 80 (3): 529-533. ( 医中誌 )

  202. 福田 将義, 大塚 和朗, 岡本 隆一. 【こんなときどうする】大腸　診断　回盲弁を越えられない 消化器内視鏡. 2022.03; 34 (3): 416-417. ( 医中誌 )

  203. 斎藤 恵子, 太田 一樹, 長堀 正和, 藤井 俊光, 竹中 健人, 大塚 和朗, 井津井 康浩, 篠原 夏美, 松下 由佳子, 岡本 隆一. 外来クローン病患者における生体インピーダンス法を用いた体組成の評価 学会誌JSPEN. 2022.02; 4 (1): 35-43. ( 医中誌 )

  204. 大塚 和朗, 竹中 健人, 齊藤 詠子, 日比谷 秀爾, 河本 亜美, 森川 亮, 藤井 俊光, 清水 寛路, 長堀 正和, 岡本 隆一 . 【炎症性腸疾患の粘膜治癒を再考する】Crohn病における小腸粘膜治癒評価の意義　バルーン内視鏡の立場から 胃と腸. 2022.02; 57 (2): 173-181. ( 医中誌 )

  205. 中川美奈. SVR後の発癌と生命予後 消化器・肝臓内科. 2021.12; 10 (6): 724-731.

  206. 大塚 和朗, 竹中 健人, 小形 典之, 岡本 隆一. 【IBDの粘膜治癒を論じる!】粘膜治癒とは?　小腸内視鏡、カプセル内視鏡 IBD Research. 2021.12; 15 (4): 228-233. ( 医中誌 )

  207. 水谷 知裕, 岡本 隆一. 【再生医療への期待～各疾患領域における現況と展望～】消化管再生医療の最新について Pharma Medica. 2021.12; 39 (12): 31-35. ( 医中誌 )

  208. 河本亜美、藤井俊光. 炎症性腸疾患の分子標的治療を総括する〜抗TNF-α抗体製剤〜 INTESTINE. 2021.09; 25 (3): 259-266.

  209. 大塚和朗, 竹中健人, 日比谷秀爾, 河本亜美, 斎藤詠子, 藤井俊光, 長堀正和, 清水寛路, 岡本隆一. 【最新の内視鏡を使いこなす】最新のスコープを使いこなす　小腸内視鏡　小腸内視鏡　オリンパス社内視鏡 消化器内視鏡. 2021.08; 33 (8): 1283-1287. ( 医中誌 )

  210. 大島　茂. 重要な鍵分子の研究動向〜炎症性腸疾患（クローン病） 創薬研究者・アカデミア研究者が知っておくべき最新の免疫学とその応用技術. 2021.08; 287-296.

  211. 大塚和朗, 竹中健人, 日比谷秀爾, 河本亜美, 齊藤詠子, 藤井俊光, 長堀正和, 岡本隆一. 【エキスパートに学ぶ、安全で楽な外来内視鏡】外来内視鏡診療への展開　外来における小腸のバルーン内視鏡検査 消化器内視鏡. 2021.06; 33 (6): 1041-1046. ( 医中誌 )

  212. 松本浩明, 宍戸華子, 小林諒平, 中村優美, 冲永康一, 平昭衣梨, 渡部　衛, 古山貴基, 近藤純由, 永山和宜, 岡本隆一. 消化管出血をきたし外科的切除を行った胃脂肪腫の2例 Progress of Digestive Endoscopy. 2021.06; 98 (1): 88-90. ( 医中誌 )

  213. 日比谷秀爾, 藤井俊光, 岡本隆一. 【炎症性腸疾患診療の新たな展開】鑑別すべき腸疾患 臨牀と研究. 2021.05; 98 (5): 569-572. ( 医中誌 )

  214. 藤井俊光, 岡本隆一. 【同種・同効薬の使い分け　疾患×基本薬のエビデンスを整理する】(第4章)消化器系の基本薬の使い分け　潰瘍性大腸炎への分子標的薬はどう選ぶ? 薬事. 2021.05; 63 (7): 1387-1394. ( 医中誌 )

  215. 日比谷秀爾、藤井俊光、岡本隆一、渡辺守. 潰瘍性大腸炎における5-ASA不耐は予後不良である INTESTINE. 2021.05; 25 (1): 115-118.

  216. 清水寛路, 岡本隆一. 【炎症性腸疾患-診療と研究の最新情報】再生医療研究から生まれる将来の新規非薬物治療 医学のあゆみ. 2021.03; 276 (11): 1063-1066. ( 医中誌 )

  217. 河本亜美、竹中健人、岡本隆一. 炎症性腸疾患患者におけるロイシンリッチ　α2グリコプロテイン測定について Modern Media. 2021.02; 67 (2): 37-39.

  218. 河本亜美, 竹中健人, 岡本隆一. 臨床検査アップデート　炎症性腸疾患患者におけるロイシンリッチα2グリコプロテイン測定について Modern Media. 2021.02; 67 (2): 61-63. ( 医中誌 )

  219. 水谷知裕, 岡本隆一. 【My Medicine(マイ・メディシン)-オルガノイド研究が拓く新しい医療のかたち】移植再生研究の観点から　腸オルガノイドによるマイ・メディシン　炎症性腸疾患に対する腸上皮幹細胞再生医療 医学のあゆみ. 2021.02; 276 (6): 662-666. ( 医中誌 )

  220. 竹中健人、北詰良雄、大塚和朗、藤井俊光、渡辺　守、岡本隆一. MR enterographyの実際と有用性 臨床消化器内科. 2021.01; 36 (2): 208-214.

  221. 藤井 俊光, 岡本 隆一, 渡辺 守. 【UC、CD以外の希少性難治性炎症性腸疾患を知る!】膠原病に伴う消化管病変 IBD Research. 2020.12; 14 (4): 255-260. ( 医中誌 )

  222. 水谷知裕、清水寛路、高橋純一、土屋麻央、平栗優衣、竹岡さや香、杉原ハディ優樹、永田紗矢香、伊藤　剛、油井史郎、渡辺　守、岡本隆一. 特集:IBD話題の治療法の現況を知る! 「IBDにおける腸管上皮再生医療」 IBD Research. 2020.09; 14 (3):

  223. 高橋純一、岡本隆一. 【消化管症候群(第3版)-その他の消化管疾患を含めて-】空腸、回腸、盲腸、結腸、直腸(上)　炎症性疾患　腸管GVHDの臨床像と鑑別診断 日本臨床. 2020.04; 別冊 (消化管症候群III): 185-189. ( 医中誌 )

  224. 鈴木康平、渡部太郎、岡本隆一. 【消化管感染症のすべて】回盲部・大腸・肛門　寄生虫感染症　鞭虫症 消化器内視鏡. 2019.10; 31 (増刊): 252-254. ( 医中誌 )

  225. 鈴木康平、渡辺　守、岡本隆一. 【腸と健康:腸オルガノイドが挑む次世代バイオモデル】腸上皮オルガノイドによる再生医療最前線 医学のあゆみ. 2019.09; 270 (11): 1049-1052. ( 医中誌 )

  226. 清水寛路、鈴木康平、岡本隆一、渡辺　守. 【炎症性腸疾患診療のupdate-診断・治療の最新知見】炎症性腸疾患の内科治療　粘膜再生治療法 臨床消化器内科. 2019.05; 34 (7): 894-898. ( 医中誌 )

  227. 仲瀬裕志、岡本隆一、寺井崇二、青井貴之. 【特集：再生医療を学ぶ―Translational researchの最先端】座談会_消化器分野における再生医療への期待 消化器病学サイエンス. 2019.03; 3 (1): 1-11. ( 医中誌 )

  228. 油井史郎、岡本隆一、渡辺　守. 【特集：急増する炎症性腸疾患に挑む】培養腸上皮細胞を用いた粘膜再生療法と再生の分子基礎 実験医学. 2018.11; 36 (18): 3092-3096.

  229. 鈴木康平、岡本隆一、渡辺　守. 【III．炎症性腸疾患の病因と病態】炎症性腸疾患における粘膜再生機構 日本臨床 増刊号 炎症性腸疾患(第２版)-病因解明と診断・治療の最新知見-. 2018.04; 76 (3): 113-118.

  230. 高橋純一、鈴木康平、平栗優衣、村野竜朗、岡本隆一、渡辺　守. 【特集：炎症性腸疾患の新しい治療戦略】腸管上皮細胞を用いた粘膜再生治療の現状と展望 Medical Science Digest. 2017.12; 43 (14): 24-27.

  231. 石橋史明、岡本隆一、渡辺　守. 腸管上皮オルガノイドを用いた細胞移植療法の展望 移植. 2017.10; 52 4-5.

  232. 髙橋純一、岡本隆一、渡辺　守. 【特集：オルガノイドがもたらす革新〜掛け算で生み出すクリエイティブ研究最前線〜】8. 内胚葉オルガノイドxTransplanation 実験医学. 2017.09; 35 (16): 2720-2725.

  233. 石橋史明、岡本隆一、渡辺　守. 【特集：幹細胞システム】腸幹細胞システム CLINICAL CALCIUM. 2017.05; 27 (6): 39-44.

  234. 岡本隆一、渡辺　守. 【炎症性腸疾患-最近の診断・治療-】 幹細胞を用いた粘膜再生治療の現状と展望 日本臨床. 2017.03; 75 (3): 477-481. ( 医中誌 )

  235. 岡本隆一、渡辺　守. 【打つ手あり!IBD治療の展望】 IBDに対する腸上皮幹細胞移植 日本医事新報. 2017.01; (4839): 36-41. ( 医中誌 )

  236. 藤井　悟、岡本隆一、渡辺　守. 【臓器の再生に向けて】 腸疾患に対する再生治療戦略 Medical Science Digest. 2017.01; 43 (1): 18-21. ( 医中誌 )

  237. 岡本 隆一, 渡辺 守. 【打つ手あり!IBD治療の展望】 IBDに対する腸上皮幹細胞移植 日本医事新報. 2017.01; (4839): 36-41. ( 医中誌 )

  238. 岡本隆一、渡辺　守. 腸上皮機能と炎症性腸疾患 日本臨床免疫学会雑誌. 2016.12; 39 (6): 522-527.

  239. 藤井　悟、岡本隆一. プロスタグランジン分解酵素15-PGDHの抑制は組織再生を促進する Chemical Biology. 2016.06; 9 (1): 17.

  240. 岡本隆一、渡辺　守. 【疫学と研究の進展】粘膜再生機構からみた炎症性腸疾患治療の展望 医学のあゆみ. 2016.03; 256 (10): 1021-1025.

  241. 岡本隆一、林　歩美、藤井　悟、水谷知裕、土屋輝一郎、中村哲也、渡辺　守. 【特集：消化管の再生】上皮幹細胞を用いた消化管再生医療 Medical Sciense Digest. 2016.02; 42 (2): 69-72.

  242. 岡本隆一、渡辺　守. 【臨床各科 差分解説：炎症性腸疾患と再生医療】再生医療による炎症性腸疾患の難治性潰瘍治療への対応が急速に発展・普及している 日本医事新報. 2016.01; (4786): 50.

  243. 岡本隆一, 渡辺　守. 【炎症性腸疾患（IBD）の最新治療】炎症性腸疾患における粘膜再生治療の展開 BIO Clinica. 2015.11; (30): 38-42.

  244. 岡本隆一, 渡辺　守. 【再生医療-新たな医療を求めて-】 臨床応用を目指した基礎研究　再生医療を目指した前臨床研究　培養腸上皮幹細胞を用いた炎症性腸疾患に対する粘膜再生治療の開発 日本臨床. 2015.06; 73 (増刊5 再生医療): 325-329. ( 医中誌 )

  245. 岡本隆一, 藤井　悟, 中田　徹, 鈴木康平, 伊藤　剛, 清水寛路, 渡辺　守. 【特集：希少消化器疾患に対する萌芽的研究の最前線】 Microscopic Colitisの難治化を予測できるか? 分子消化器病. 2015.03; 12 (1): 32-36. ( 医中誌 )

  246. 岡本隆一, 渡辺　守. 【特集：炎症性腸疾患-病態研究から標的治療への展開-】 病態研究から標的治療へ　腸上皮幹細胞研究の新展開と粘膜再生療法への挑戦 最新医学. 2015.02; 70 (2): 217-221. ( 医中誌 )

  247. 鈴木 康平, 岡本 隆一, 勝倉 暢洋, 渡部 太郎, 和田 祥城, 赤尾 信明, 渡辺 守, 太田 伸生. 当院における消化管寄生虫感染症の診断・治療経験 Clinical Parasitology. 2014.12; 25 (1): 9-12. ( 医中誌 )

  248. 岡本隆一、村野竜朗、渡辺　守. 【炎症性腸疾患の病態解明と治療戦略】炎症性腸疾患における上皮再生機構の解明 消化器内科. 2013.11; 57 (5): 505-508. ( 医中誌 )

  249. 岡本隆一、渡辺　守. トピックスmicroscopic colitis. 専門医のための消化器病学　第2版. 2013.10; 216-217.

  250. 岡本隆一、渡辺　守. 【特集：Microscopic Colitisのすべて】2．わが国における実態-研究班による全国調査の結果から. 大腸疾患NOW 2012. 2012.10; 25-31.

  251. 伊藤 剛、岡本隆一、清水寛路、村野竜朗、水谷知裕、油井史郎、土屋輝一郎、中村哲也、渡辺　守. 【腫瘍をめぐるQ&A】(Question45) Lgr5とは？ Surgery Frontier. 2012.06; 19 (2): 224-227. ( 医中誌 )

  252. 岡本隆一、渡辺　守. 【炎症性腸疾患-病因解明と診断・治療の最新知見-】 炎症性腸疾患の病因と病態　炎症性腸疾患における粘膜再生機構 日本臨床. 2012.02; 70 116-121. ( 医中誌 )

  253. 岡本 隆一, 清水 寛路, 村野 竜朗, 伊藤 剛, 堀田 伸勝, 鄭 秀, 加納 嘉人, 野崎 賢吾, 福田 将義, 水谷 知裕, 油井 史郎, 土屋 輝一郎, 中村 哲也, 渡辺 守. 【特集：免疫統御からみた新しいIBD治療】 腸管細胞の分化・再生の制御機構からみたIBD治療へのアプローチ IBD Research. 2011.12; 5 (4): 226-231. ( 医中誌 )

  254. 中村哲也、岡本隆一、渡辺 守. 【特集：粘膜免疫機構:神秘性理解から新概念創出の時代へ】上皮細胞再生による腸炎治療戦略 Medical Science Digest. 2011.11; 37 (13): 548-550. ( 医中誌 )

  255. 岡本隆一、渡辺　守. 【臨床に役立つ腸管免疫学の最新のトピックス】腸管上皮維持にStem cellはどう関与するのか？ INTESTINE. 2011.09; 15 (5): 443-447. ( 医中誌 )

  256. 岡本隆一、渡辺 守. 【特集：医農連携と機能性食品】炎症と組織再生 Functional Food. 2011.07; 15 (5): 52-56. ( 医中誌 )

  257. 岡本隆一、渡辺 守. 【特集：炎症性腸疾患の診断と治療をめぐる新展開】炎症性腸疾患における粘膜修復機構 Mebio. 2011.03; 28 (3): 20-29. ( 医中誌 )

  258. 岡本隆一、渡辺守. 【シグナル伝達を理解するために必要な知識(第27回)】(No.53)　腸管におけるNotchシグナル伝達 分子消化器病. 2010.09; 7 (3): 281-285. ( 医中誌 )

  259. 岡本 隆一, 秋山 純子, 鄭 秀, 加納 嘉人, 水谷 知裕, 油井 史郎, 岩嵜 美智子, 土屋 輝一郎, 中村 哲也, 渡辺 守. 【トピックス第14回：IBDの最新の話題　基礎編】　炎症粘膜上皮の再生制御機構 IBD Research. 2010.06; 4 (2): 121-126. ( 医中誌 )

  260. 岡本隆一、渡辺守. 【特集：臨床に結びつく自己免疫疾患の基礎知識】 Notchシグナル異常と炎症性腸疾患 Mebio. 2010.06; 27 (6): 38-46. ( 医中誌 )

  261. 岡本 隆一, 秋山 純子, 鄭 秀, 加納 嘉人, 水谷 知裕, 油井 史郎, 岩嵜 美智子, 土屋 輝一郎, 中村 哲也, 渡辺 守. 【特集：幹細胞を用いた消化器再生医療の展望】 クローン病・潰瘍性大腸炎の難治性潰瘍も幹細胞を用いた再生医療で治せるか 分子消化器病. 2009.12; 6 (4): 353-358. ( 医中誌 )

  262. 岡本隆一、土屋輝一郎、新垣美郁代、秋山純子、中村哲也、渡辺　守. 【特集：ここまで明らかになった！IBD の病因・病態】goblet（杯）細胞分裂と潰瘍性大腸炎 IBD Research. 2009.09; 3 (3): 35-40.

  263. 岡本隆一、渡辺　守. 【特集：炎症性腸疾患の新規治療を探る】腸管上皮再生は局所炎症を改善させるか？ 分子消化器病. 2009.06; 6 (2): 18-22. ( 医中誌 )

  264. 岡本隆一、秋山純子、小野塚泉、油井史郎、土屋輝一郎、中村哲也、渡辺　守. 【第二部 炎症性腸疾患をめぐる最近の話題】炎症性腸疾患における上皮分化 増殖機構の解析と粘膜再生治療への応用 大腸疾患NOW 2009. 2009.01; 153-157.

  265. 岡本隆一、土屋輝一郎、渡辺守. 【潰瘍性大腸炎：クローン病】腸管上皮の分化・再生 診断と治療. 2008.12; 96 (12): 2555-2562. ( 医中誌 )

  266. 吉岡篤史、大島　茂、岡本隆一、土屋輝一郎、中村哲也、金井隆典、渡辺守. Flagellinの刺激は腸管上皮細胞においてIL-7の分泌を抑制する 消化器と免疫. 2008.06; 44 38-41. ( 医中誌 )

  267. 岡本隆一,土屋輝一郎,渡辺　守. 【特集 分子メカニズムから探る IBD の病態と治療アプローチ】腸管上皮細胞分化制御とIBDに対する上皮細胞療法の可能性 IBD Research. 2007.09; 1 (3): 43-47.

  268. 吉岡篤史、岡本隆一、渡辺守. 【特集：炎症性腸疾患UP TO DATE】潰瘍性大腸炎・クローン病の病因・病態 綜合臨床. 2007.08; 56 (8): 2435-2440. ( 医中誌 )

  269. 岡本隆一、渡辺守. PPARβ/δはHedgehogシグナルの調節を介してパネート細胞分化を調節する Review of Gastroenterology & Clinical Gastroenterology and Hepatology 2007. 2007.03; 1 (4): 31-34.

  270. 岡本隆一、土屋輝一郎、渡辺守. 【特集：消化器疾患の病態生理-胃・十二指腸潰瘍を中心に-】消化管上皮の再生におけるNotchシグナルの役割 Progress in Medicine 2007. 2007.03; 27 (3): 603-605. ( 医中誌 )

  271. 岡本隆一、渡辺守. 腸杯細胞とNotch、炎症性腸疾患 医学のあゆみ. 2007.02; 220 (6): 528-529. ( 医中誌 )

  272. 岡本隆一、中村哲也、渡辺守. 活性型Notchの発現調節によるヒト腸管上皮再生の可能性 消化器病学の進歩2005-モノグラフ-　消化器病学のニューフロンテイア編. 2005.12; 361-363.

  273. 岡本隆一、松本智子、渡辺守. 骨髄由来細胞による上皮再生治療 大腸疾患NOW 2005. 2005.12; 198-201.

  274. 松本智子、岡本隆一、渡辺守. 【膵・腸の再生】腸管上皮の再生・分化制御による難治性腸疾患治療 日本再生医療学会雑誌. 2005.08; 4 (3): 357-362. ( 医中誌 )

  275. 岡本隆一、松本智子、渡辺守. 【特集：再生医学　クローン・幹細胞から医療へ】　再生医療最前線　消化管上皮の再生 綜合臨床. 2005.01; 54 (1): 155-160. ( 医中誌 )

  276. 松本智子、岡本隆一、渡辺守. 【消化管粘膜修復機構のメカニズムを探る-生体防御と消化管粘膜修復機構-】消化管粘膜修復と幹細胞のはたらきを探る 分子消化器病. 2004.09; 1 (3): 214-221. ( 医中誌 )

  277. 岡本隆一、松本智子、渡辺守. 骨髄由来細胞の消化管上皮への分化 最新医学. 2004.06; 59 (6): 1252-1256. ( 医中誌 )

  278. 岡本隆一、渡辺守. 【特集：幹細胞と消化器疾患】腸上皮の再生,分化制御による疾患治療 G.I. Research. 2004.04; 12 (2): 111-116. ( 医中誌 )

  279. 松本智子、岡本隆一、渡辺守. 腸管幹細胞　 分子細胞治療. 2004.03; 3 383-384.

  280. 松本智子、岡本隆一、渡辺守. 【特集：消化器臓器の幹細胞と発生・再生を探る】骨髄細胞は腸管上皮細胞へどのように分化されるのか 分子消化器病. 2004.03; 1 (1): 6-11. ( 医中誌 )

  281. 金井隆典、岡本隆一、渡辺　守. 炎症性腸疾患 Annual Review消化器2004. 2004.01; 250-261. ( 医中誌 )

  282. 岡本隆一、渡辺　守. 【消化管上皮の再生・分化】消化管上皮の再生・分化制御—臨床応用への期待— 日本消化器病学会雑誌. 2003.09; 100 1369-1374. ( 医中誌 )

  283. 岡本隆一、渡辺守. 腸管上皮再生における骨髄由来細胞の役割 感染・炎症・免疫. 2003.09; 33 (3): 209-216. ( 医中誌 )

  284. 山崎元美、岡田英里子、松本智子、岡本隆一、中村哲也、金井隆典、矢島知治、日比紀文、田邊将信、竹内勤、石川博通、渡辺守. 腸管粘膜浸潤IL-7レセプター高発現細胞による慢性大腸炎発症 消化器と免疫. 2003.07; 39 37-40. ( 医中誌 )

  285. 岡本隆一、渡辺守. 【再生医学】腸管上皮　恒常性維持と傷害修復機構 Molecular Medicine 40巻臨時増刊号. 2003.03; 40 236-244. ( 医中誌 )

  286. 渡辺守、 岡本隆一. 潰瘍性大腸炎と腸管粘膜IL-7/IL-7受容体機構 免疫疾患-state of arts Ver.2 (別冊　医学のあゆみ). 2002.03; 529-533. ( 医中誌 )

  287. 岡本隆一、山崎元美、渡辺守. 【粘膜免疫の分子機構とその破綻-粘膜免疫担当組織・粘膜担当細胞の特殊性】粘膜IL-7/IL-7受容体機構による粘膜内リンパ球増殖調節機構 医学のあゆみ. 2001.10; 199 (1): 53-58. ( 医中誌 )

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