Published Papers & Misc - OKAMOTO Ryuichi

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  1. Taro Shimizu, Masato Miyoshi, Sei Kakinuma, Jun Tsuchiya, Daisuke Yamane, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Kaho Yamada, Kotomi Shinozaki, Ayako Sato, Shun Kaneko, Fukiko Kawai-Kitahata, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto. Bile acid-FXR signaling facilitates the long-term maintenance of hepatic characteristics in human iPSC-derived organoids. Cell Rep. 2025.05; 44 (5): 115675. ( PubMed, DOI )

  2. Eri Oshina, Masanori Kobayashi, Ryuichi Okamoto. Functional Gallbladder Disorder: Characteristic Hepatobiliary Scintigraphy Findings. Intern Med. 2025.04; 64 (7): 1119-1120. ( PubMed, DOI )

  3. Ryosuke Hamamura, Masanori Kobayashi, Ryuichi Okamoto. Endoscopic transpapillary gallbladder drainage using a novel cholangioscope. Dig Endosc. 2025.04; 37 (4): 434-435. ( PubMed, DOI )

  4. Makoto Naganuma, Hisashi Shiga, Masayuki Shimoda, Minoru Matsuura, Kento Takenaka, Toshimitsu Fujii, Shojiro Yamamoto, Mao Matsubayashi, Taku Kobayashi, Nobuo Aoyama, Daisuke Saito, Kaoru Yokoyama, Kei Moriya, Kiichiro Tsuchiya, Shunsuke Shibui, Ami Kawamoto, Hiromichi Shimizu, Ryuichi Okamoto, Kazuki Sakamoto, Katsuki Yaguchi, Reiko Kunisaki, Shintaro Akiyama, Ryohei Hayashi, Keisuke Hasui, Shuji Kanmura, Shigeki Bamba, Yoshiyuki Mishima, Kazuki Kakimoto, Shinya Sugimoto, Atsushi Nakazawa, Takayuki Abe, Haruhiko Ogata, Tadakazu Hisamatsu, . First-line biologics as a treatment for ulcerative colitis: a multicenter randomized control study. J Gastroenterol. 2025.04; 60 (4): 430-441. ( PubMed, DOI )

  5. Hady Yuki Sugihara, Ryuichi Okamoto, Tomohiro Mizutani. Intestinal organoids: The path towards clinical application. Eur J Cell Biol. 2025.03; 104 (1): 151474. ( PubMed, DOI )

  6. Shintaro Akiyama, Hiromichi Shimizu, Akiko Tamura, Kaoru Yokoyama, Toshiyuki Sakurai, Mariko Kobayashi, Makoto Eizuka, Shunichi Yanai, Kei Nomura, Tomoyoshi Shibuya, Masahiro Takahara, Sakiko Hiraoka, Minako Sako, Atsushi Yoshida, Kozo Tsuruta, Shinichiro Yoshioka, Miki Koroku, Teppei Omori, Masayuki Saruta, Takayuki Matsumoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Toshimitsu Fujii. Comparative Efficacy and Safety of Three Janus Kinase Inhibitors in Ulcerative Colitis: A Real-World Multicentre Study in Japan. Aliment Pharmacol Ther. 2025.02; 61 (3): 524-537. ( PubMed, DOI )

  7. Jun Tsuchiya, Masato Miyoshi, Sei Kakinuma, Fukiko Kawai-Kitahata, Akihide Kamiya, Taro Shimizu, Ayako Sato, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Rion Kamimae, Shun Kaneko, Miyako Murakawa, Sayuri Nitta, Mina Nakagawa, Mamoru Watanabe, Yasuhiro Asahina, Ryuichi Okamoto. Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived Model. Cell Mol Gastroenterol Hepatol. 2025; 19 (2): 101422. ( PubMed, DOI )

  8. Shintaro Akiyama, Hiromichi Shimizu, Akiko Tamura, Kaoru Yokoyama, Toshiyuki Sakurai, Mariko Kobayashi, Makoto Eizuka, Shunichi Yanai, Kei Nomura, Tomoyoshi Shibuya, Masahiro Takahara, Sakiko Hiraoka, Minako Sako, Atsushi Yoshida, Kozo Tsuruta, Shinichiro Yoshioka, Miki Koroku, Teppei Omori, Masayuki Saruta, Takayuki Matsumoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Toshimitsu Fujii. Efficacy and Safety of Three Janus Kinase Inhibitors in Ulcerative Colitis Patients over and under 65 Years of Age: A Real-World Comparative Analysis. Inflamm Intest Dis. 2025; 10 (1): 180-186. ( PubMed, DOI )

  9. Junichi Takahashi, Hady Yuki Sugihara, Shu Kato, Sho Kawasaki, Sayaka Nagata, Ryuichi Okamoto, Tomohiro Mizutani. Controlled aggregative assembly to form self-organizing macroscopic human intestine from induced pluripotent stem cells. Cell Rep Methods. 2024.12; 4 (12): 100930. ( PubMed, DOI )

  10. Miyako Murakawa, Mina Nakagawa, Hisaaki Nishimura, Shun Kaneko, Masato Miyoshi, Fukiko Kawai-Kitahata, Sayuri Nitta, Jun Tsuchiya, Taro Shimizu, Keiya Watakabe, Tomohiro Mochida, Kento Inada, Yasuhiro Iizuka, Hideki Sakai, Yuki Sakurai, Ayako Sato, Seishin Azuma, Takahiro Kawamura, Chiaki Maeyashiki, Masayuki Kurosaki, Fumihiko Kusano, Hideki Watanabe, Hitoshi Kurata, Yuko Karakama, Takeo Fujiwara, Yuki Nagata, Toshihiro Tanaka, Sei Kakinuma, Ryuichi Okamoto, Yasuhiro Asahina. High serum gamma-glutamyltransferase level after hepatitis C virus elimination is a risk factor for the development of hepatocellular carcinoma. Hepatol Res. 2024.12; 54 (12): 1128-1138. ( PubMed, DOI )

  11. Kento Takenaka, Tadakazu Hisamatsu, Taku Kobayashi, Hironori Yamamoto, Naoki Ohmiya, Ryohei Hayashi, Katsuyoshi Matsuoka, Masayuki Saruta, Akira Andoh, Norimasa Fukata, Kenji Watanabe, Hiroyuki Imaeda, Fumihito Hirai, Takayuki Matsumoto, Akihiro Hirakawa, Tomonori Yano, Minoru Matsuura, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe. Inadequate Efficacy of Biologics for Treating Proximal Ileal Lesions in Crohn's Disease; A Prospective Multicenter Study. Clin Gastroenterol Hepatol. 2024.12; Online ahead of print ( PubMed, DOI )

  12. Ryo Morikawa, Kentaro Nitta, Shuntaro Yasuda, Yoshihito Kano, Rika Noji, Satoru Aoyama, Shingo Sato, Sadakatsu Ikeda, Ryuichi Okamoto, Masashi Nagata, Takehiko Mori, Mitsukuni Suenaga. Identification of risk factors for gastrointestinal immune-related adverse events associated with immune check point inhibitors. Expert Opin Drug Saf. 2024.12; 1-8. ( PubMed, DOI )

  13. Hiromune Katsuda, Masanori Kobayashi, Go Ito, Ami Kawamoto, Susumu Krimura, Hiroyuki Sato, Akihiro Hirakawa, Keiichi Akahoshi, Atsushi Kudo, Kazuo Ohtsuka, Ryuichi Okamoto. Evaluating endoscopic ultrasound-guided tissue acquisition for diagnosis of small pancreatic neuroendocrine neoplasms. Endosc Int Open. 2024.11; 12 (11): E1379-E1385. ( PubMed, DOI )

  14. Shun Ishido, Masanori Kobayashi, Ryuichi Okamoto. Low-cost and reliable method for confirming residual bile duct stones utilizing a novel peroral cholangioscope. Dig Endosc. 2024.10; 36 (10): 1173-1175. ( PubMed, DOI )

  15. Watakabe K, Miyoshi M, Kakinuma S, Sato A, Tsuchiya J, Shimizu T, Mochida T, Inada K, Kaneko S, Kawai-Kitahata F, Murakawa M, Nitta S, Nakagawa M, Oshima S, Watanabe M, Ma A, Asahina Y, Okamoto R. A20 in hepatic stellate cells suppresses chronic hepatitis by inhibiting DCLK1-JNK pathway-dependent chemokines. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2024.07; 38 (13): e23757. ( PubMed, DOI )

  16. Masanori Kobayashi, Mao Niimi, Hiromune Katsuda, Keiichi Akahoshi, Yuko Kinowaki, Masanao Sasaki, Akihiro Hirakawa, Ukihide Tateishi, Minoru Tanabe, Ryuichi Okamoto. Optimization of Endoscopic Ultrasound Characteristics in the Diagnosis of Malignant Intraductal Papillary Mucinous Neoplasm. Pancreas. 2024.07; 53 (6): e521-e527. ( PubMed, DOI )

  17. Kazuma Saito, Masanori Kobayashi, Minato Yokoyama, Towako Taguchi, Koichiro Kimura, Takumi Akashi, Yasuhisa Fujii, Ryuichi Okamoto. Transjejunal fine-needle biopsy using a forward-viewing echoendoscope for diagnosis of a rare hereditary paraganglioma. VideoGIE. 2024.07; 9 (7): 329-332. ( PubMed, DOI )

  18. Shintaro Akiyama, Kaoru Yokoyama, Soichi Yagi, Shinichiro Shinzaki, Kozo Tsuruta, Shinichiro Yoshioka, Minako Sako, Hiromichi Shimizu, Mariko Kobayashi, Toshiyuki Sakurai, Kei Nomura, Tomoyoshi Shibuya, Masahiro Takahara, Sakiko Hiraoka, Kyohei Sugai, Shunichi Yanai, Atsushi Yoshida, Miki Koroku, Teppei Omori, Masayuki Saruta, Takayuki Matsumoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Toshimitsu Fujii. Efficacy and safety of filgotinib for ulcerative colitis: A real-world multicenter retrospective study in Japan. Aliment Pharmacol Ther. 2024.06; 59 (11): 1413-1424. ( PubMed, DOI )

  19. Keito Suzuki, Yutaka Yasui, Kaoru Tsuchiya, Hiroaki Matsumoto, Yudai Yamazaki, Naoki Uchihara, Yuki Tanaka, Haruka Miyamoto, Michiko Yamada-Shimizu, Taisei Keitoku, Risa Okada, Mayu Higuchi, Kenta Takaura, Shohei Tanaka, Chiaki Maeyashiki, Nobuharu Tamaki, Hiroyuki Nakanishi, Yuka Takahashi, Yasuhiro Asahina, Ryuichi Okamoto, Masayuki Kurosaki, Namiki Izumi. Impact of immune-related adverse events in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab. J Gastroenterol Hepatol. 2024.06; 39 (6): 1183-1189. ( PubMed, DOI )

  20. Hiromune Katsuda, Masanori Kobayashi, Ryuichi Okamoto. Endoscopic recanalization of an occluded Braun anastomosis using an endoscopic injection needle. Dig Endosc. 2024.05; Online ahead of print ( PubMed, DOI )

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