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SUZUKI Nobuharu
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Graduating School 【 display / non-display 】
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Shinshu University, Faculty of Science, 2000.03, Graduated
Graduate School 【 display / non-display 】
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Hokkaido University, Graduate School, Division of Earth Environmental Science and Technology, Doctor's Course, 2004.09, Completed
Campus Career 【 display / non-display 】
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2010.09-2014.01Tokyo Medical and Dental University, Graduate School of Health Care Sciences, Biomedical Laboratory Sciences, Life Sciences and Bio-informatics, Biochemistry and Biophysics, Junior Associate Professor
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2014.02-2018.03Tokyo Medical and Dental University, Graduate School of Health Care Sciences, Biomedical Laboratory Sciences, Life Sciences and Bio-informatics, Biochemistry and Biophysics, Associate Professor
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2018.04-2020.06Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Biomedical Sciences and Engineering, Division of Biomedical Laboratory Sciences, Department of Molecular and Cellular Biology, Associate Professor
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2020.07-2023.03Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Biomedical Sciences and Engineering, Division of Biomedical Laboratory Sciences, Department of Molecular and Cellular Biology, Associate Professor
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2023.04Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Biomedical Sciences and Engineering, Division of Biomedical Laboratory Sciences, Department of Clinical Bioanalysis and Molecular Biology, Associate Professor
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2023.05-NowTokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Biomedical Sciences and Engineering, Division of Biomedical Laboratory Sciences, Department of Clinical Bioanalysis and Molecular Biology, Associate Professor
External Career 【 display / non-display 】
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2004.04-2006.02Graduate School of Environmental Earth Science, JSPS Research Fellow
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2006.03-2008.02NIDCR, NIH, JSPS Research Fellow (NIH)
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2008.03-2010.04NIDCR, NIH, Visiting Fellow
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2010.04-2010.08NIDCR, NIH, Research Fellow
Academic Society Affiliations 【 display / non-display 】
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The Japanese Society for Neuroscience
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American Society for Matrix Biology
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The American Society for Cell Biology
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Society for Neuroscience
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The Molecular Biology Society of Japan
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The Japanese Society for Matrix Biology and Medicine
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The Japanese Society for myelin
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The Japanese Society for Neurochemistry
Academic Activity 【 display / non-display 】
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2021.09-NowCells Topical Advisory Panel
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2021.09-NowFrontiers in Cell and Developmental Biologynal Topic Editor
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2023.09-NowFrontiers in Cell and Developmental Biologynal Review Editor
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2023.09-NowNeurology International Editorial Board
Research Areas 【 display / non-display 】
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Neuroscience-general
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Molecular biology
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Cell biology
Qualification Acquired 【 display / non-display 】
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First Kind of Junior High School Teacher License
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First Kind of High School Teacher License
Research Theme 【 display / non-display 】
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Molecular Biological Study of the Myelin Function in the Gender Difference of Dementia and Depression, 2024.04 - 2027.03
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Development of the axonal diameter-dependent demyelination model due to oligodendrocyte subpopulation and the elucidation of its mechanism, 2024.04 - 2027.03
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Identification of the survival factor of small diameter axons on the CNS dysmyelination and its application, 2024.04 - 2026.03
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Morphological and Biochemical Profiling of the Degeneration of Small Caliber Axons Using a Murine Model for Myelin-related Diseases, 2020.12 - 2024.03
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Elucidation of the mechanism of size-dependent axon degeneration with myelination defect and identification of the novel marker for the degeneration, 2020.11 - 2021.11
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Study on the mechanism of myelination of small diameter axons in the CNS and its potential application for related diseases, 2020.04 - 2023.03
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The mechanism of CNS myelination through axon diameters and oligodendrocyte subtypes, 2019.08 - 2022.08
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Elucidation of the molecular mechanism of neuronal activity-dependent myelination in the central nervous system, 2019.04 - 2021.03
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Research for elucidation of the molecular mechanism of neuronal activity-dependent myelination and its application, 2019.01 - 2021.03
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Study on the molecular mechanism of tremors through teneurin-4 gene function, 2016.04 - 2019.03
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Study on the molecular mechanism of tremors through teneurin-4 gene function, 2016.04 - 2017.03
Published Papers & Misc 【 display / non-display 】
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Momona Yamada, Miho Iwase, Binri Sasaki, Nobuharu Suzuki. The molecular regulation of oligodendrocyte development and CNS myelination by ECM proteins Frontiers in Cell and Developmental Biology. 2022.09; 10 952135.
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Chikako Hayashi, Nobuharu Suzuki, Riko Takahashi, Chihiro Akazawa. Development of type I/II oligodendrocytes regulated by teneurin-4 in the murine spinal cord. Sci Rep. 2020.05; 10 (1): 8611. ( PubMed, DOI )
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Chikako Hayashi, Nobuharu Suzuki, Yo Mabuchi, Naomi Kikura, Yukina Hosoda, Susana de Vega, Chihiro Akazawa. The extracellular domain of teneurin-4 promotes cell adhesion for oligodendrocyte differentiation. Biochem Biophys Res Commun. 2020.02; 523 (1): 171-176. ( PubMed, DOI )
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Nobuharu Suzuki, Mai Hyodo, Chikako Hayashi, Yo Mabuchi, Kaori Sekimoto, Chinami Onchi, Kiyotoshi Sekiguchi, Chihiro Akazawa. Laminin α2, α4, and α5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precursor Cells. Sci Rep. 2019.12; 9 (1): 19882. ( PubMed, DOI )
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Chikako Hayashi, Nobuharu Suzuki. Heterogeneity of Oligodendrocytes and Their Precursor Cells. Adv. Exp. Med. Biol.. 2019.11; 1190 53-62. ( PubMed, DOI )
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Yusuke Ogata, Yo Mabuchi, Kosuke Shinoda, Yuta Horiike, Mitsuru Mizuno, Koji Otabe, Eriko Grace Suto, Nobuharu Suzuki, Ichiro Sekiya, Chihiro Akazawa. Anterior cruciate ligament-derived mesenchymal stromal cells have a propensity to differentiate into the ligament lineage. Regen Ther. 2018.06; 8 20-28. ( PubMed, DOI )
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Kana Ishii, Hidetoshi Sakurai, Nobuharu Suzuki, Yo Mabuchi, Ichiro Sekiya, Kiyotoshi Sekiguchi, Chihiro Akazawa. Recapitulation of Extracellular LAMININ Environment Maintains Stemness of Satellite Cells In Vitro. Stem Cell Reports. 2018.02; 10 (2): 568-582. ( PubMed, DOI )
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Kana Ishii, Nobuharu Suzuki, Yo Mabuchi, Ichiro Sekiya, Chihiro Akazawa. Technical advantage of recombinant collagenase for isolation of muscle stem cells. Regen Ther. 2017.12; 7 1-7. ( PubMed, DOI )
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Nobuharu Suzuki, Kaori Sekimoto, Chikako Hayashi, Yo Mabuchi, Tetsuya Nakamura, Chihiro Akazawa. Differentiation of Oligodendrocyte Precursor Cells from Sox10-Venus Mice to Oligodendrocytes and Astrocytes. Sci Rep. 2017.10; 7 (1): 14133. ( PubMed, DOI )
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Eriko Grace Suto, Yo Mabuchi, Nobuharu Suzuki, Koji Suzuki, Yusuke Ogata, Miyu Taguchi, Takeshi Muneta, Ichiro Sekiya, Chihiro Akazawa. Prospectively isolated mesenchymal stem/stromal cells are enriched in the CD73+ population and exhibit efficacy after transplantation Sci Rep. 2017.07; 7 (1): 4838. ( PubMed, DOI )
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Susana de Vega, Kentaro Hozumi, Nobuharu Suzuki, Risa Nonaka, Eimi Seo, Anna Takeda, Tomoko Ikeuchi, Motoyoshi Nomizu, Yoshihiko Yamada, Eri Arikawa-Hirasawa. Identification of peptides derived from the C-terminal domain of fibulin-7 active for endothelial cell adhesion and tube formation disruption. Biopolymers. 2016.03; 106 (2): 184-195. ( PubMed, DOI )
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Kana Ishii, Nobuharu Suzuki, Yo Mabuchi, Naoki Ito, Naomi Kikura, So-Ichiro Fukada, Hideyuki Okano, Shin'ichi Takeda, Chihiro Akazawa. Muscle Satellite Cell Protein Teneurin-4 Regulates Differentiation During Muscle Regeneration. Stem Cells. 2015.10; 33 (10): 3017-3027. ( PubMed, DOI )
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High capacity of purified mesenchymal stem cells for cartilage regeneration 2015.04;
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Yusuke Ogata, Yo Mabuchi, Mayu Yoshida, Eriko Grace Suto, Nobuharu Suzuki, Takeshi Muneta, Ichiro Sekiya, Chihiro Akazawa. Purified Human Synovium Mesenchymal Stem Cells as a Good Resource for Cartilage Regeneration. PLoS ONE. 2015; 10 (6): e0129096. ( PubMed, DOI )
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Nobuharu Suzuki, Chihiro Mizuniwa, Kana Ishii, Yusuke Nakagawa, Kunikazu Tsuji, Takeshi Muneta, Ichiro Sekiya, Chihiro Akazawa. Teneurin-4, a transmembrane protein, is a novel regulator that suppresses chondrogenic differentiation. J Orthop Res. 2014.07; 32 (7): 915-922. ( PubMed, DOI )
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Susana de Vega, Nobuharu Suzuki, Risa Nonaka, Takako Sasaki, Patricia Forcinito, Eri Arikawa-Hirasawa, Yoshihiko Yamada. A C-terminal fragment of fibulin-7 interacts with endothelial cells and inhibits their tube formation in culture. Arch Biochem Biophys. 2014.03; 545 148-153. ( PubMed, DOI )
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Nobuharu Suzuki, Tadahiro Numakawa, Joshua Chou, Susana de Vega, Chihiro Mizuniwa, Kaori Sekimoto, Naoki Adachi, Hiroshi Kunugi, Eri Arikawa-Hirasawa, Yoshihiko Yamada, Chihiro Akazawa. Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling. FASEB J. 2014.03; 28 (3): 1386-1397. ( PubMed, DOI )
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Ryota Suzuki, Katsumi Miyahara, Hiroshi Murakami, Takashi Doi, Geoffrey J Lane, Yo Mabuchi, Nobuharu Suzuki, Atsuyuki Yamataka, Chihiro Akazawa. Abnormal neural crest innervation in Sox10-Venus mice with all-trans retinoic acid-induced anorectal malformations. Pediatr Surg Int. 2014.02; 30 (2): 189-195. ( PubMed, DOI )
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Nobuharu Suzuki, Masaya Fukushi, Keisuke Kosaki, Andrew D Doyle, Susana de Vega, Keigo Yoshizaki, Chihiro Akazawa, Eri Arikawa-Hirasawa, Yoshihiko Yamada. Teneurin-4 is a novel regulator of oligodendrocyte differentiation and myelination of small-diameter axons in the CNS. J Neurosci. 2012.08; 32 (34): 11586-11599. ( PubMed, DOI )
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Muneaki Ishijima, Nobuharu Suzuki, Kentaro Hozumi, Tomoya Matsunobu, Keisuke Kosaki, Haruka Kaneko, John R Hassell, Eri Arikawa-Hirasawa, Yoshihiko Yamada. Perlecan modulates VEGF signaling and is essential for vascularization in endochondral bone formation. Matrix Biol. 2012.05; 31 (4): 234-245. ( PubMed, DOI )
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Nobuharu Suzuki, Kentaro Hozumi, Shunsuke Urushibata, Takashi Yoshimura, Yamato Kikkawa, Jessica D Gumerson, Daniel E Michele, Matthew P Hoffman, Yoshihiko Yamada, Motoyoshi Nomizu. Identification of alpha-dystroglycan binding sequences in the laminin alpha2 chain LG4-5 module. Matrix Biol.. 2010.03; 29 (2): 143-151. ( PubMed, DOI )
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Kentaro Hozumi, Nobuharu Suzuki, Yoshihiko Uchiyama, Fumihiko Katagiri, Yamato Kikkawa, Motoyoshi Nomizu. Chain-specific heparin-binding sequences in the laminin alpha chain LG45 modules. Biochemistry. 2009.06; 48 (23): 5375-5381. ( PubMed, DOI )
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Shu Takaki, Kozue Kato-Takagaki, Nobuharu Suzuki, Shinya Oishi, Yamato Kikkawa, Motoyoshi Nomizu. Cyclic peptide analogs of laminin active sequences enhance the biological activity. Adv. Exp. Med. Biol.. 2009; 611 297-298. ( PubMed )
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Mayumi Mochizuki, Deborah Philp, Kentaro Hozumi, Nobuharu Suzuki, Yoshihiko Yamada, Hynda K Kleinman, Motoyoshi Nomizu. Angiogenic activity of syndecan-binding laminin peptide AG73 (RKRLQVQLSIRT). Arch. Biochem. Biophys.. 2007.03; 459 (2): 249-255. ( PubMed, DOI )
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Kozue Kato-Takagaki, Nobuharu Suzuki, Fumiharu Yokoyama, Shu Takaki, Koji Umezawa, Junichi Higo, Mayumi Mochizuki, Yamato Kikkawa, Shinya Oishi, Atsushi Utani, Motoyoshi Nomizu. Cyclic peptide analysis of the biologically active loop region in the laminin alpha3 chain LG4 module demonstrates the importance of peptide conformation on biological activity. Biochemistry. 2007.02; 46 (7): 1952-1960. ( PubMed, DOI )
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Kentaro Hozumi, Nobuharu Suzuki, Peter K Nielsen, Motoyoshi Nomizu, Yoshihiko Yamada. Laminin alpha1 chain LG4 module promotes cell attachment through syndecans and cell spreading through integrin alpha2beta1. J. Biol. Chem.. 2006.10; 281 (43): 32929-32940. ( PubMed, DOI )
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Fumiharu Yokoyama, Nobuharu Suzuki, Yuichi Kadoya, Atsushi Utani, Hiroko Nakatsuka, Norio Nishi, Masahiro Haruki, Hynda K Kleinman, Motoyoshi Nomizu. Bifunctional peptides derived from homologous loop regions in the laminin alpha chain LG4 modules interact with both alpha 2 beta 1 integrin and syndecan-2. Biochemistry. 2005.07; 44 (28): 9581-9589. ( PubMed, DOI )
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Naoki Ichikawa, Shingo Kasai, Nobuharu Suzuki, Norio Nishi, Shinya Oishi, Nobutaka Fujii, Yuichi Kadoya, Kozo Hatori, Yoshikuni Mizuno, Motoyoshi Nomizu, Eri Arikawa-Hirasawa. Identification of neurite outgrowth active sites on the laminin alpha4 chain G domain. Biochemistry. 2005.04; 44 (15): 5755-5762. ( PubMed, DOI )
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Akane Kondo, Junko Inagaki, Kazuko Kobayashi, Hideo Tsukamoto, Daisuke Yamamoto, Mikiya Nakatsuka, Nobuharu Suzuki, Motoyoshi Nomizu, Satoshi Amano, Hidehiko Matsubayashi, Tatsuji Yasuda, Luis R Lopez, Yehuda Shoenfeld, Tsunehisa Makino, Eiji Matsuura. Characterization of a murine anti-laminin-1 monoclonal antibody (AK8) produced by immunization with mouse-derived laminin-1. Clin. Dev. Immunol.. 2005.03; 12 (1): 67-73. ( PubMed )
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Nobuharu Suzuki, Fumiharu Yokoyama, Motoyoshi Nomizu. Functional sites in the laminin alpha chains. Connect. Tissue Res.. 2005; 46 (3): 142-152. ( PubMed, DOI )
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Yutaka Momota, Nobuharu Suzuki, Yoshitoshi Kasuya, Takashi Kobayashi, Masako Mizoguchi, Fumiharu Yokoyama, Motoyoshi Nomizu, Hiroshi Shinkai, Toshiroh Iwasaki, Atsushi Utani. Laminin alpha3 LG4 module induces keratinocyte migration: involvement of matrix metalloproteinase-9. J. Recept. Signal Transduct. Res.. 2005; 25 (1): 1-17. ( PubMed, DOI )
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Fumiharu Yokoyama, Nobuharu Suzuki, Masahiro Haruki, Norio Nishi, Shinya Oishi, Nobutaka Fujii, Atsushi Utani, Hynda K Kleinman, Motoyoshi Nomizu. Cyclic peptides from the loop region of the laminin alpha 4 chain LG4 module show enhanced biological activity over linear peptides. Biochemistry. 2004.10; 43 (42): 13590-13597. ( PubMed, DOI )
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Hiroshi Matsuura, Yutaka Momota, Kaoru Murata, Hironori Matsushima, Nobuharu Suzuki, Motoyoshi Nomizu, Hiroshi Shinkai, Atsushi Utani. Localization of the laminin alpha4 chain in the skin and identification of a heparin-dependent cell adhesion site within the laminin alpha4 chain C-terminal LG4 module. J. Invest. Dermatol.. 2004.03; 122 (3): 614-620. ( PubMed, DOI )
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Nobuharu Suzuki, Naoki Ichikawa, Shingo Kasai, Masanori Yamada, Norio Nishi, Hiroshi Morioka, Hironobu Yamashita, Yasuo Kitagawa, Atsushi Utani, Matthew P Hoffman, Motoyoshi Nomizu. Syndecan binding sites in the laminin alpha1 chain G domain. Biochemistry. 2003.11; 42 (43): 12625-12633. ( PubMed, DOI )
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Nobuharu Suzuki, Hiroko Nakatsuka, Mayumi Mochizuki, Norio Nishi, Yuichi Kadoya, Atsushi Utani, Shinya Oishi, Nobutaka Fujii, Hynda K Kleinman, Motoyoshi Nomizu. Biological activities of homologous loop regions in the laminin alpha chain G domains. J. Biol. Chem.. 2003.11; 278 (46): 45697-45705. ( PubMed, DOI )
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Atsushi Utani, Yutaka Momota, Hideharu Endo, Yoshitoshi Kasuya, Konrad Beck, Nobuharu Suzuki, Motoyoshi Nomizu, Hiroshi Shinkai. Laminin alpha 3 LG4 module induces matrix metalloproteinase-1 through mitogen-activated protein kinase signaling. J. Biol. Chem.. 2003.09; 278 (36): 34483-34490. ( PubMed, DOI )
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Junko Inagaki, Mayumi Sugiura-Ogasawara, Motoyoshi Nomizu, Mikiya Nakatsuka, Katsuo Ikuta, Nobuharu Suzuki, Keiko Kaihara, Kazuko Kobayashi, Tatsuji Yasuda, Yehuda Shoenfeld, Koji Aoki, Eiji Matsuura. An association of IgG anti-laminin-1 autoantibodies with endometriosis in infertile patients. Hum. Reprod.. 2003.03; 18 (3): 544-549. ( PubMed )
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Ikuko Okazaki, Nobuharu Suzuki, Norio Nishi, Atsushi Utani, Hiroshi Matsuura, Hiroshi Shinkai, Hironobu Yamashita, Yasuo Kitagawa, Motoyoshi Nomizu. Identification of biologically active sequences in the laminin alpha 4 chain G domain. J. Biol. Chem.. 2002.10; 277 (40): 37070-37078. ( PubMed, DOI )
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Kozue Kato, Atsushi Utani, Nobuharu Suzuki, Mayumi Mochizuki, Masanori Yamada, Norio Nishi, Hiroshi Matsuura, Hiroshi Shinkai, Motoyoshi Nomizu. Identification of neurite outgrowth promoting sites on the laminin alpha 3 chain G domain. Biochemistry. 2002.09; 41 (35): 10747-10753. ( PubMed )
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M Nomizu, F Yokoyama, N Suzuki, I Okazaki, N Nishi, M L Ponce, H K Kleinman, Y Yamamoto, S Nakagawa, T Mayumi. Identification of homologous biologically active sites on the N-terminal domain of laminin alpha chains. Biochemistry. 2001.12; 40 (50): 15310-15317. ( PubMed )
Conference Activities & Talks 【 display / non-display 】
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Nobuharu Suzuki, Hinako Saito, Riko Takahashi, Nanako Yamada, Mio Fujisato, Kanoko Mitsunari, Binri Sasaki, Yukina Hosoda, Chikako Hayashi, Toru Doi, Mikael Simons, and Ryunosuke Ohkawa. The maintenance of small diameter axons after dysmyelination in teneurin-4 deficient mice. . CELL BIO24 (An ASCB/EMBO Meeting) 2024.12.15 San Diego, CA, US.
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Binri Sasaki, Chikako Hayashi, Nanako Yamada, Nobuharu Suzuki. The regulation of actin-cytoskeletal organization by teneurin-4 is important for CNS myelination by oligodendrocytes. CELL BIO24 (An ASCB/EMBO Meeting) 2024.12.15 San Diego, CA, US.
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Nanako Yamada, Momona Yamada, Reina Ono, Binri Sasaki, Nobuharu Suzuki. The induction of apoptosis in oligodendrocyte lineage cells by extracellular Chromogranin B. CELL BIO24 (An ASCB/EMBO Meeting) 2024.12.15 San Diego, CA, US.
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藤里澪, 齋藤日菜子, 高橋りこ, 大野玲菜, 大川龍之介, 鈴木喜晴. The maintenance of unmyelinated small diameter axons by monocarboxylate transporters(モノカルボン酸トランスポーターによる無髄小径軸索の維持). 第47回日本分子生物学会年会 2024.11.29 福岡国際会議場・マリンメッセ福岡.
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Hitomi Misawa, Yuichi Hiraoka, Nobuharu Suzuki. Sex Differences in Survival and Differentiation of Primary Culture Oligodendrocytes. 第47回日本分子生物学会年会 2024.11.29 福岡国際会議場・マリンメッセ福岡.
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Nanako Yamada, Momona Yamada, Reina Ono, Nobuharu Suzuki. The effect of extracellular Chromogranin B on the survival of oligodendrocyte lineage cells. 第47回日本分子生物学会年会 2024.11.29 福岡国際会議場・マリンメッセ福岡.
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Reina Ono, Mizuki Fukuhara, Yuki Munakata, Nanako Yamada, Momona Yamada, Nobuharu Suzuki. Effects of disease-derived variants and of the interaction with Chromogranin B on the cell adhesion activity of Teneurin-4. 第47回日本分子生物学会年会 2024.11.29 福岡国際会議場・マリンメッセ福岡.
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Binri Sasaki, Chikako Hayashi, Nobuharu Suzuki. The transmembrane protein teneurin-4 drives myelination by promoting actin depolymerization in oligodendrocytes. 第47回日本分子生物学会年会 2024.11.28 福岡国際会議場・マリンメッセ福岡.
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Chisato Banno, Binri Sasaki, Momona Yamada, Keisuke Hamada, Yuji Yamada, Yamato Kikkawa, Motoyoshi Nomizu, Nobuharu Suzuki. Identification of active peptides from the extracellular matrix protein laminin-411 that promotes the formation of myelin membranes in oligodendrocytes. 第46回日本分子生物学会年会 2023.12.08
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Hinako Saito, Riko Takahashi, Mio Fujisato, Yukina Hosoda, Chikako Hayashi, Ryunosuke Ohkawa, and Nobuharu Suzuki. The molecular mechanism of axon maintenance after myelination defect. 第46回日本分子生物学会年会 2023.12.08
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Mio Fujisato, Hinako Saito, Riko Takahashi, Reina Ohno and Nobuharu Suzuki. The expression and function of monocarboxylate transporters for the maintenance of unmyelinated small axons in the CNS. 第46回日本分子生物学会年会 2023.12.07
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Reina Ono, Riko Takahashi, Hinako Saito, Mio Fujisato and Nobuharu Suzuki. The RNA-Seq analysis in reactive gliosis by the murine genetical dysmyelination. 第46回日本分子生物学会年会 2023.12.07
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Binri Sasaki, Chikako Hayashi, and Nobuharu Suzuki. Cell adhesion protein teneurin-4 regulates actin polymerization in oligodendrocytes for CNS myelination. 第46回日本分子生物学会年会 2023.12.07
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Mizuki Fukuhara, Yuki Munakata, Reina Ohno, Nanako Yamada, Momona Yamada, Chikako Hayashi, and Nobuharu Suzuki. Evaluation of cell adhesion activity of mutant teneurin-4 and its effect on the diseases. 第46回日本分子生物学会年会 2023.12.06
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Mizuki Fukuhara, Chikako Hayashi, Yuki Munakata, Reina Ohno, Nanako Yamada, Momona Yamada, and Nobuharu Suzuki. The molecular mechanism of CNS myelination through the cell adhesion of teneurin-4 and its effect on the diseases. 第66回日本神経化学会大会 2023.07.08
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Hinako Saito, Riko Takahashi, Mio Fujisato, Yukina Hosoda, Chikako Hayashi, and Nobuharu Suzuki. The molecular mechanism of axonal survival in the murine dysmyelination. 第66回日本神経化学会大会 2023.07.08
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Momona Yamada, Miho Iwase, Chikako Hayashi, de Vega Susana, Nobuharu Suzuki. An extracellular matrix protein Fibulin-7 positively regulates oligodendrocyte differentiation through the N-terminal active sequence. 第45回日本分子生物学会年会 2022.12.01
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Miho Iwase, Chikako Hayashi, Binri Sasaki, Momona Yamada, Nobuharu Suzuki. Teneurin-4 promotes CNS myelin formation through a molecular interaction with actin-regulating proteins in oligodendrocytes. 第45回日本分子生物学会年会 2022.11.30
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Momona Yamada, Miho Iwase, Chikako Hayashi, Susana de Vega, Nobuharu Suzuki. The extracellular matrix protein fibulin-7 positively regulates oligodendrocyte differentiation through the interaction between myelin and neuronal axons. Neuroscience 2022 2022.11.13 San Diego Convention Center, San Diego, CA, USA
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Miho Iwase, Chikako Hayashi, Binri Sasaki, Momona Yamada, Nobuharu Suzuki. Teneurin-4 forms a molecular complex with actin-regulating proteins in oligodendrocytes and promotes myelin sheath formation in the CNS. Neuroscience 2022 2022.11.13 San Diego Convention Center, San Diego, CA, USA
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Nobuharu Suzuki, Riko Takahashi, Hinako Saito, Yukina Hosoda, Chikako Hayashi. The Maintenance of Small Caliber Axons in Teneurin-4 Deficient Mice with the Congenital Hypomyelination in the CNS. 第65回日本神経化学会大会 2022.07.02
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Miho Iwase, Momona Yamada, Chikako Hayashi, Nobuharu Suzuki. The molecular function of the actin cytoskeletal regulator Arpc1a in proliferation and morphogenesis of oligodendrocyte-lineage cells. 第65回日本神経化学会大会 2022.07.01
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Momona Yamada, Miho Iwase, Chikako Hayashi, Susana de Vega, Nobuharu Suzuki. Fibulin-7, an extracellular matrix protein, positively regulates oligodendrocyte differentiation and attachment to neuronal axons. 第65回日本神経化学会大会 2022.07.01
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Riko Takahashi, Hinako Saito, Yukina Hosoda, Chikako Hayashi, Nobuharu Suzuki. The maintenance of unmyelinated small diameter axons in the CNS. 第44回日本分子生物学会年会 2021.12.03
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Momona Yamada, Miho Iwase, Chikako Hayashi, de Vega Susana, Nobuharu Suzuki. The extracellular matrix protein Fibulin-7 relates to the cell interaction for myelination in CNS. 第44回日本分子生物学会年会 2021.12.03
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Riko Takahashi, Hinako Saito, Yukina Hosoda, Chikako Hayashi, Nobuharu Suzuki. The maintenance of small diameter axons after myelination defect in the CNS. 第64回日本神経化学会大会 2021.09.30
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Momona Yamada, Miho Iwase, Chikako Hayashi, de Vega Susana, Nobuharu Suzuki. The extracellular matrix protein fibulin-7 regulates cellular interaction for CNS myelination. 第64回日本神経化学会大会 2021.09.30
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Miho Iwase, Momona Yamada, Chikako Hayashi, Nobuharu Suzuki. The expression pattern and functional analysis of Arpc1a controlling actin cytoskeleton at the initial stage of myelination. 第64回日本神経化学会大会 2021.09.30
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Riko Takahashi, Chikako Hayashi, Miho Iwase, Nobuharu Suzuki. Teneurin-4 regulates the generation of type I/II oligodendrocytes that myelinate small diameter axons.. 第63回日本神経化学会大会 2020.09.11
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Yuki Munakata, Yukina Hosoda, Hiromi Kurumada, Chikako Hayashi, Nobuharu Suzuki. The crucial role of teneurin-4 associated with actin binding protein CNP in myelination and axonal maintenance.. 第63回日本神経化学会大会 2020.09.11
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Momo Ooishi, Chinami Onchi, Momona Yamada, Chikako Hayashi, Nobuharu Suzuki. Promoted oligodendrocyte precursor cell proliferation and surivival via laminin E3 fragments.. 第63回日本神経化学会大会 2020.09.10
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Nobuharu Suzuki. Cell Adhesion Proteins Regulate Myelination of Small Caliber Axons Critically Involved in Myelin-related Diseases. 第63回日本神経化学会大会 2020.09.10
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Chikako Hayashi, Yukina Hosoda, Chinami Onchi, Nobuharu Suzuki. Teneurin-4 positively regulates oligodendrocyte-axon adhesion and myelination through the binding with teneurins.. 12th FENS Forum of Neuroscience 2020.07.12
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Nobuharu Suzuki, Chikako Hayashi, Yo Mabuchi, Naomi Kikura, Yukina Hosoda, Susana de Vega, Chihiro Akazawa. Teneurin-4 gene associated with mental disorders regulates CNS myelination through cell adhesion between oligodendrocytes and neuronal axons. The 10th Takeda Science Foundation Symposium on PharmaSciences 2020.01.24
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Nobuharu Suzuki, Yoshihiko Yamada. Teneurin-4 Is a Positive Regulator of CNS Myelination through Oligodendrocyte Process Formation. XIV European Meeting on Glial Cells in Health and Disease 2019.07.11
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Chikako Hayashi, Nobuharu Suzuki, Naomi Kikura, Yukina Hosoda, Yo Mabuchi, Chihiro Akazawa. Molecular Interaction between Oligodendrocytes and Axons through Teneurins for CNS Myelination. XIV European Meeting on Glial Cells in Health and Disease 2019.07.11
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Chikako Hayashi, Nobuharu Suzuki, Naomi Kikura, Yukina Hosoda, Yo Mabuchi, Chihiro Akazawa. Oligodendrocyte-Axon Interaction via Teneurin-4 Controls Cell Adhesion and Morphogenesis of Oligodendrocytes for Myelination. Neuroscience 2018 2018.11.03 San Diego Convention Center, San Diego, CA, USA
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Nobuharu Suzuki, Yoshihiko Yamada. Teneurin-4 regulates oligodendrocyte process formation in CNS myelination. Neuroscience 2018 2018.11.03 San Diego Convention Center, San Diego, CA, USA
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Teneurin-4 is a transmembrane protein regulating cell adhesion and cytoskeletal organization in oligodendrocytes. 2017.11.14
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Kaori Sekimoto, Nobuharu Suzuki, Yo Mabuchi, Chikako Hayashi, Tetsuya Nakamura, and Chihiro Akazawa.. Isolation of Sox10-Venus oligodendrocyte precursor cells differentiable to oligodendrocytes and type 2 astrocytes. 第37回日本分子生物学会年会 2014.11.27 横浜
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Eriko Grace Suto, Yo Mabuchi, Nobuharu Suzuki, Asuka Koyanagi, Yoshiko Kawabata, Nobutake Ozeki, Yusuke Nakagawa, Takeshi Muneta, Ichiro Sekiya, Chihiro Akazawa. Purified Mesenchymal Stem Cells Have High Ability for differentiation in vivo.. 第37回日本分子生物学会年会 2014.11.27 横浜
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石井佳菜、鈴木喜晴、 馬渕洋、木倉直美、伊藤尚基、深田宗一郎、武田伸一、赤澤智宏. Teneurin-4 Suppresses Proliferation and Differentiation of Muscle Satellite Cells in Vitro Myogenesis. 第37回日本分子生物学会年会 2014.11.27 横浜
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緒方勇亮、馬渕洋、吉田茉由、須藤絵里子グレース、鈴木喜晴、宗田大、関矢一郎、赤澤智宏. ヒト滑膜由来間葉系幹細胞の増殖能力及び軟骨分化能力の解析」. 第37回日本分子生物学会年会 2014.11.27 横浜
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Chihiro Akazawa. The New Japanese Regulation for Regenerative Medicine. The 9th New York Stem Cell Foundation Annual Meeting 2014.10.22 New York
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Eriko Grace Suto, Yo Mabuchi, Nobuharu Suzuki, Asuka Koyanagi, Yoshiko Kawabata, Takeshi Muneta, Ichiro Sekiya, and Chihiro Akazawa.. Purified Mesenchymal Stem Cells maintain purity and have high ability of chondrogenic regeneration after prolonged culture.. The 9th New York Stem Cell Foundation Annual Meeting 2014.10.22 New York
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Kana Ishii, Nobuharu Suzuki, Yo Mabuchi, Naomi Kikura, Naoki Ito, Shin’ich Takeda, and Chihiro Akazawa.. Suppressive Function of Teneurin-4, a Muscle Satellite Cell Protein, in Cell Proliferation and Differentiation during Myogenesis.. The 9th New York Stem Cell Foundation Annual Meeting 2014.10.22 New York
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Chihiro Akazawa. Large Scale iPSC Initiatives Arround the World. 12th Annual Meeting of ISSCR 2014.06.18 Vancouver
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Susana de Vega, Eimi Seo, Anna Takeda, Nobuharu Suzuki, Risa Nonaka, Kentaro Hozumi, Motoyoshi Nomizu, Yoshihiko Yamada, and Eri Arikawa-Hirasawa. Identification of Fibulin-7 Peptides Active for Endothelial Cell Adhesion and Tube Formation. 第46回日本結合組織学会学術大会 2014.06.06 名古屋
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Kaori Sekimoto, Nobuharu Suzuki, Yo Mabuchi, and Chihiro Akazawa.. In vitro Analysis of Differentiation of Oligodendrocytes and Astrocytes Using Sox10-Venus Mice.. Experimental Biology 2014 2014.04.30 San Diego
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Kana Ishii, Nobuharu Suzuki, Yo Mabuchi, and Chihiro Akazawa.. Teneurin-4 is a novel suppressor of myogenesis.. Experimental Biology 2014 2014.04.30 San Diego
Awards & Honors 【 display / non-display 】
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The Excellent Poster Presentation Award at the 63rd Annual Meeting of the Japanese Society for Neurochemistry ,The Japanese Society for Neurochemistry,2020.09
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The Excellent Poster Presentation Award at the 63rd Annual Meeting of the Japanese Society for Neurochemistry ,The Japanese Society for Neurochemistry,2020.09
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The silver award at the pitch contest for cryo-EM gateway,Tokyo Medical and Dental University,2020.03
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The Excellent Presentation Award at the 61st Annual Meeting of the Japanese Society for Neurochemistry ,The Japanese Society for Neurochemistry,2018.09
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Tokyo Medical and Dental University Medical Research Award 2013,Tokyo Medican and Dental University,2014.01
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Fellows Award for Research Excellence 2008 at NIH,National Institute of Health,2009.09
Campus class subject 【 display / non-display 】
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Biochemistry, Lecture I,2023 - Now
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Biochemistry, Lecture I,2023 - Now
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Clinical Bioanalysis and Molecular Biology, Laboratory,2023 - Now
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Biomedical Laboratory Science Seminar I,2023 - Now
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Biomedical Laboratory Science Seminar II,2023 - Now
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English for Health Care Sciences(I),2022
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Global Communication(II),2022
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Global Communication(I),2022
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English for Health Care Sciences(II),2022
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Biochemistry, Lecture,2020 - Now
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Biochemistry,2020 - Now
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Genetic analysis, Laboratory,2020 - 2023
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Molecular and Cellular Biology,2019 - 2022
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Medical Genetics and Human Genome Science, Lecture,2011 - 2023
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Biochemistry, Laboratory,2010 - Now
Social Contribution 【 display / non-display 】
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Nobuharu Suzuki, Neurology International:Editorial Board,2023.09.01 - Now
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Nobuharu Suzuki, Frontiers in Cell and Developmental Biology:Review Editor,2023.09.01 - Now
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Nobuharu Suzuki, Cells:Topical Advisory Panel,2021.09.01 - Now
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Nobuharu Suzuki, Frontiers in Cell and Developmental Biology:Topic Editor,2021.09.01 - Now