Personnel Information

写真a

SHIMIZU Norio


Job title

Associate Professor

Laboratory Address

2-3-10 kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, JAPAN

Mail Address

The inquiry by e-mail is 《here

Degree 【 display / non-display

  • PhD, Tohoku University

Campus Career 【 display / non-display

  • 2015.01
    -
    2017.03
    Tokyo Medical and Dental University, Research and Industry-University Alliance Organization, Center for Stem Cell and Regenerative Medicine, Associate Professor
  • 1996.10
    -
    2014.12
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Frontier Research Unit Virus Research Unit, Associate Professor
  • 1996.10
    -
    2020.03
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Pathological Cell Biology, Associate Professor
  • 1996.10
    -
    2020.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Pathological Cell Biology, Associate Professor
  • 2017.04
     
     
    Tokyo Medical and Dental University, Institute of Research, Division of Advanced Research, Center for Stem Cell and Regenerative Medicine, Associate Professor
  • 2017.05
    -
    2020.05
    Tokyo Medical and Dental University, Institute of Research, Division of Advanced Research, Center for Stem Cell and Regenerative Medicine, Associate Professor
  • 2018.05
    -
    Now
    Tokyo Medical and Dental University, Medical Hospital, Central Clinical Facilities, Center for Transfusion Medicine and Cell Therapy, Associate Professor
  • 2020.06
    -
    2020.09
    Tokyo Medical and Dental University, Institute of Research, Division of Advanced Research, Center for Stem Cell and Regenerative Medicine, Associate Professor
  • 2020.10
    -
    2022.02
    Tokyo Medical and Dental University, Institute of Research, Division of Advanced Research, Center for Stem Cell and Regenerative Medicine, Associate Professor
  • 2022.03
    -
    Now
    Tokyo Medical and Dental University, Institute of Research, a, Center for Stem Cell and Regenerative Medicine, Associate Professor

▼display all

Research Areas 【 display / non-display

  • Virology

 

Published Papers & Misc 【 display / non-display

  1. Mitsuru Mizuno,Yori K, Takeuchi T, Yamaguchi T, Watanabe K, Tomaru Y, Shimizu N, Sekiya I.. Cross-contamination risk and decontamination during changeover after cell-product processing Regenerative Therapy. 2022.12; 22 30-38. ( PubMed, DOI )

  2. Nakano T, Katayama Y, Sakamoto M, Shimizu Y, Inoie M, Shimizu N, Yamanaka H, Tsuge I, Saito S, Morimoto N. Establishment of a keratinocyte and fibroblast bank for clinical applications in Japan. Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs. 2022.05; ( PubMed, DOI )

  3. Ohashi A, Uemura Y, Yoshimori M, Wada N, Imadome KI, Yudo K, Koyama T, Shimizu N, Nishio M, Arai A. The Plasma Level of Interleukin-1β Can Be a Biomarker of Angiopathy in Systemic Chronic Active Epstein-Barr Virus Infection. Frontiers in microbiology. 2022.04; 13 874998. ( PubMed, DOI )

  4. Tsunemine H, Sasak M, Zushi Y, Saitoh T, Shimizu N, Tomaru Y, Aoyama Y, Yamamoto R, Sakai T, Arima N, Kodaka T, Takahashi T.. Feasibility of the Routine Clinical Use of a Multiplex Virus Polymerase Chain Reaction Assay Based on Blood Virus Detection in Hematopoietic Stem Cell-Transplanted Patients. International Journal of Clinical Medicine. 2022.02; 2022 (13): 67-81. ( DOI )

  5. Sugita S, Hono A, Fujino S, Futatsugi Y, Yunomae Y, Shimizu N, Takahashi M. Detection of Mycoplasma Contamination in Transplanted Retinal Cells by Rapid and Sensitive Polymerase Chain Reaction Test. International journal of molecular sciences. 2021.11; 22 (22): ( PubMed, DOI )

  6. Yoshimori M, Nishio M, Ohashi A, Tateishi M, Mimura A, Wada N, Saito M, Shimizu N, Imadome KI, Arai A. Interferon-γ Produced by EBV-Positive Neoplastic NK-Cells Induces Differentiation into Macrophages and Procoagulant Activity of Monocytes, Which Leads to HLH. Cancers. 2021.10; 13 (20): ( PubMed, DOI )

  7. Yoshimori M, Shibayama H, Imadome KI, Kawano F, Ohashi A, Nishio M, Shimizu N, Kurata M, Fujiwara S, Arai A. Antineoplastic and anti-inflammatory effects of bortezomib on systemic chronic active EBV infection. Blood advances. 2021.04; 5 (7): 1805-1815. ( PubMed, DOI )

  8. Nakano S, Tomaru Y, Kubota T, Takase H, Mochizuki M, Shimizu N, Sugita S, Direct Strip PCR Project Groups.. Multiplex solid-phase real-time polymerase chain reaction without DNA extraction: A rapid intraoperative diagnosis using microvolumes. Ophthalmology. 2020.09; - (20): 30933-30937. ( PubMed, DOI )

  9. Mizuno M, Endo K, Katano H, Tsuji A, Kojima N, Watanabe K, Shimizu N, Morio T, Sekiya I. The environmental risk assessment of cell-processing facilities for cell therapy in a Japanese academic institution. PloS one. 2020.08; 15 (8): e0236600. ( PubMed, DOI )

  10. Nakano S, Tomaru Y, Kubota T, Takase H, Mochizuki M, Shimizu N, Sugita S, Strip PCR Project Group.. Evaluation of a multiplex Strip PCR test for infectious uveitis: a prospective multi-center study. American journal of ophthalmology. 2019.11; 213 (0): 252-259. ( PubMed, DOI )

  11. Funakoshi Yu, Ito Kenta, Morino Saeko, Kinoshita Kazue, Morikawa Yoshihiko, Kono Tatsuo, Doan Yen Hai, Shimizu Hiroyuki, Hanaoka Nozomu, Konagaya Masami, Fujimoto Tsuguto, Suzuki Ai, Chiba Takashi, Akiba Tetsuya, Tomaru Yasuhiro, Watanabe Ken, Shimizu Norio, Horikoshi Yuho. 2015年の日本の小児病院におけるエンテロウイルスD68型呼吸器感染症(Enterovirus D68 respiratory infection in a children's hospital in Japan in 2015) Pediatrics International. 2019.08; 61 (8): 768-776. ( ichushi )

  12. Funakoshi Y, Ito K, Morino S, Kinoshita K, Morikawa Y, Kono T, Doan YH, Shimizu H, Hanaoka N, Konagaya M, Fujimoto T, Suzuki A, Chiba T, Akiba T, Tomaru Y, Watanabe K, Shimizu N, Horikoshi Y. Enterovirus D68 respiratory infection in a children's hospital in Japan in 2015. Pediatrics international : official journal of the Japan Pediatric Society. 2019.05; ( PubMed, DOI )

  13. Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H. Publisher Correction: Defective Epstein-Barr virus in chronic active infection and haematological malignancy. Nature microbiology. 2019.03; 4 (3): 544. ( PubMed, DOI )

  14. Okuno Y, Murata T, Sato Y, Muramatsu H, Ito Y, Watanabe T, Okuno T, Murakami N, Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Narita Y, Yoshida M, Goshima F, Kawada JI, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H. Defective Epstein-Barr virus in chronic active infection and haematological malignancy. Nature microbiology. 2019.01; 4 (3): 404-413. ( PubMed, DOI )

  15. Yoshida Masaaki, Hariya Takehiro, Yokokura Shunji, Maruyama Kazuichi, Sato Kota, Sugita Sunao, Tomaru Yasuhiro, Shimizu Norio, Nakazawa Toru. Diagnosing superinfection keratitis with multiplex polymerase chain reaction(和訳中) Journal of Infection and Chemotherapy. 2018.12; 24 (11-12): 1004-1008. ( ichushi )

  16. Okuno Yusuke, Murata Takayuki, Sato Yoshitaka, Muramatsu Hideki, Ito Yoshinori, Watanabe Takahiro, Okuno Tatsuya, Murakami Norihiro, Yoshida Kenichi, Sawada Akihisa, Inoue Masami, Kawa Keisei, Seto Masao, Ohshima Koichi, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Narita Yohei, Yoshida Masahiro, Goshima Fumi, Kawada Junichi, Nishida Tetsuya, Kiyoi Hitoshi, Kato Seiichi, Nakamura Shigeo, Morishima Satoko, Fujiwara Shigeyoshi, Shimizu Norio, Isobe Yasushi, Noguchi Masaaki, Kikuta Atsushi, Iwatsuki Keiji, Takahashi Yoshiyuki, Kojima Seiji, Ogawa Seishi, Kimura Hiroshi. The Presence of Defective Epstein-Barr Virus (EBV) Infection in Patients with EBV-Associated Hematological Malignancy BLOOD. 2018.11; 132 ( DOI )

  17. Shiori Kinoshita, Takashi Ishida, Asahi Ito, Tomoko Narita, Ayako Masaki, Susumu Suzuki, Takashi Yoshida, Masaki Ri, Shigeru Kusumoto, Hirokazu Komatsu, Norio Shimizu, Hiroshi Inagaki, Taruho Kuroda, Arne Scholz, Ryuzo Ueda, Takaomi Sanda, Shinsuke Iida. Cyclin-dependent kinase 9 as a potential specific molecular target in NK cell leukemia/lymphoma. Haematologica. 2018.08; ( PubMed, DOI )

  18. Masaaki Yoshida, Takehiro Hariya, Shunji Yokokura, Kazuichi Maruyama, Kota Sato, Sunao Sugita, Yasuhiro Tomaru, Norio Shimizu, Toru Nakazawa. Diagnosing superinfection keratitis with multiplex polymerase chain reaction. J. Infect. Chemother.. 2018.07; ( PubMed, DOI )

  19. Erika Onozawa, Haruna Shibayama, Honami Takada, Ken-Ichi Imadome, Sho Aoki, Mayumi Yoshimori, Norio Shimizu, Shigeyoshi Fujiwara, Takatoshi Koyama, Osamu Miura, Ayako Arai. STAT3 is constitutively activated in chronic active Epstein-Barr virus infection and can be a therapeutic target. Oncotarget. 2018.07; 9 (57): 31077-31089. ( PubMed, DOI )

  20. Nakano Satoko, Tomaru Yasuhiro, Takase Hiroshi, Kubota Toshiaki, Mochizuki Manabu, Shimizu Norio, Sugita Sunao. Evaluation of a multiplex Strip PCR examination for infectious uveitis and endophthalmitis: A prospective multi-center study INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2018.07; 59 (9):

  21. Setsuko Shioda, Fumio Kasai, Ken Watanabe, Kohei Kawakami, Azusa Ohtani, Masashi Iemura, Midori Ozawa, Akemi Arakawa, Noriko Hirayama, Eiko Kawaguchi, Tomoko Tano, Sayaka Miyata, Motonobu Satoh, Norio Shimizu, Arihiro Kohara. Screening for 15 pathogenic viruses in human cell lines registered at the JCRB Cell Bank: characterization of in vitro human cells by viral infection. R Soc Open Sci. 2018.05; 5 (5): 172472. ( PubMed, DOI )

  22. Watanabe K, Otabe K, Shimizu N, Komori K, Mizuno M, Katano H, Koga H, Sekiya I. High-sensitivity virus and mycoplasma screening test reveals high prevalence of parvovirus B19 infection in human synovial tissues and bone marrow. Stem cell research & therapy. 2018.03; 9 (1): 80. ( PubMed, DOI )

  23. Takasawa Kei, Nakagawa Ryuichi, Takishima Shigeru, Moriyama Kengo, Watanabe Ken, Kiyohara Koji, Hasegawa Takeshi, Shimohira Masahiro, Kashimada Kenichi, Shimizu Norio, Morio Tomohiro. Cause of acute encephalitis/encephalopathy in Japanese children diagnosed by a rapid and comprehensive virological detection system and differences in their clinical presentations Brain & Development. 2018.02; 40 (2): 107-115. ( ichushi )

  24. Sasaki M, Shimizu N, Zushi Y, Saito T, Tsunemine H, Itoh K, Aoyama Y, Goto Y, Kodaka T, Tsuji G, Senda E, Fujimori T, Itoh T, Takahashi T. Analysis of gastrointestinal virus infection in immunocompromised hosts by multiplex virus PCR assay. AIMS microbiology. 2018; 4 (2): 225-239. ( PubMed, DOI )

  25. Selvarajan V., Osato M., Nah G. S. S., Yan J., Chung T-H, Voon D. C-C, Ito Y., Ham M. F., Salto-Tellez M., Shimizu N., Choo S-N, Fan S., Chng W-J, Ng S-B. RUNX3 is oncogenic in natural killer/T-cell lymphoma and is transcriptionally regulated by MYC LEUKEMIA. 2017.10; 31 (10): 2219-2227. ( DOI )

  26. Kei Takasawa, Ryuichi Nakagawa, Shigeru Takishima, Kengo Moriyama, Ken Watanabe, Koji Kiyohara, Takeshi Hasegawa, Masahiro Shimohira, Kenichi Kashimada, Norio Shimizu, Tomohiro Morio. Cause of acute encephalitis/encephalopathy in Japanese children diagnosed by a rapid and comprehensive virological detection system and differences in their clinical presentations. Brain Dev.. 2017.08; ( PubMed, DOI )

  27. Takehiro Hariya, Kazuichi Maruyama, Sunao Sugita, Masayo Takahashi, Shunji Yokokura, Kota Sato, Yasuhiro Tomaru, Norio Shimizu, Toru Nakazawa. Multiplex polymerase chain reaction for pathogen detection in donor/recipient corneal transplant tissue and donor storage solution. Sci Rep. 2017.07; 7 (1): 5973. ( PubMed, DOI )

  28. Nagao M, Yoshioka Y, Saito T, Tsunemine H, Ito K, Kodaka T, Tsuji G, Watanabe K, Shimizu N and Takahashi T. Six Cases of Infectious Mononucleosis by Cytomegalovirus as Diagnosed by Multiplex Virus PCR Assay. Journal of Blood & Lymph. 2017.07; 7 (2): ( DOI )

  29. Setsuko Shioda, Fumio Kasai, Midori Ozawa, Noriko Hirayama, Motonobu Satoh, Yousuke Kameoka, Ken Watanabe, Norio Shimizu, Huamin Tang, Yasuko Mori, Arihiro Kohara. The human vascular endothelial cell line HUV-EC-C harbors the integrated HHV-6B genome which remains stable in long term culture. Cytotechnology. 2017.07; ( PubMed, DOI )

  30. Kana Washio, Takashi Oka, Lamia Abdalkader, Michiko Muraoka, Akira Shimada, Megumi Oda, Hiaki Sato, Katsuyoshi Takata, Yoshitoyo Kagami, Norio Shimizu, Seiichi Kato, Hiroshi Kimura, Kazunori Nishizaki, Tadashi Yoshino, Hirokazu Tsukahara. Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia. Leuk. Lymphoma. 2017.04; 1-12. ( PubMed, DOI )

  31. Honami Takada, Ken-Ichi Imadome, Haruna Shibayama, Mayumi Yoshimori, Ludan Wang, Yasunori Saitoh, Shin Uota, Shoji Yamaoka, Takatoshi Koyama, Norio Shimizu, Kouhei Yamamoto, Shigeyoshi Fujiwara, Osamu Miura, Ayako Arai. EBV induces persistent NF-κB activation and contributes to survival of EBV-positive neoplastic T- or NK-cells. PLoS ONE. 2017.03; 12 (3): e0174136. ( PubMed, DOI )

  32. Nakano S, Sugita S, Tomaru Y, Hono A, Nakamuro T, Kubota T, Takase H, Mochizuki M, Takahashi M, Shimizu N.. Establishment of Multiplex Solid-Phase Strip PCR Test for Detection of 24 Ocular Infectious Disease Pathogens. Invest. Ophthalmol. Vis. Sci.. 2017.03; 58 (3): 1553-1559. ( PubMed, DOI )

  33. Natsuko Inazawa, Tsukasa Hori, Masanori Nojima, Makoto Saito, Keita Igarashi, Masaki Yamamoto, Norio Shimizu, Yuko Yoto, Hiroyuki Tsutsumi. Virus reactivations after autologous hematopoietic stem cell transplantation detected by multiplex PCR assay. J. Med. Virol.. 2017.02; 89 (2): 358-362. ( PubMed, DOI )

  34. Takada H, Imadome KI, Shibayama H, Yoshimori M, Wang L, Saitoh Y, Uota S, Yamaoka S, Koyama T, Shimizu N, Yamamoto K, Fujiwara S, Miura O, Arai A. Correction: EBV induces persistent NF-κB activation and contributes to survival of EBV-positive neoplastic T- or NK-cells. PloS one. 2017; 12 (8): e0182682. ( PubMed, DOI )

  35. Tsunemine H, Yoshioka Y, Nagao M, Tomaru Y, Saitoh T, Adachi S, Shimizu N, Takahashi T.. Multiplex Polymerase Chain Reaction Assay for Early Diagnosis of Viral Infection INTECH. 2016.12; ( DOI )

  36. Shotaro Ando, Jun-Ichi Kawada, Takahiro Watanabe, Michio Suzuki, Yoshitaka Sato, Yuka Torii, Masato Asai, Fumi Goshima, Takayuki Murata, Norio Shimizu, Yoshinori Ito, Hiroshi Kimura. Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. Oncotarget. 2016.11; 7 (47): 76793-76805. ( PubMed, DOI )

  37. Shibayama Haruna, Imadome Ken-ichi, Sakashita Chizuko, Watanabe Ken, Kawano Fuyuko, Shimizu Norio, Koyama Takatoshi, Fujiwara Shigeyoshi, Miura Osamu, Arai Ayako. BortezomibのEBV-T/NK-LPDに対するin vitroおよびin vivo効果(In vitro and in vivo effects of bortezomib on EBV-T/NK-LPDs) 臨床血液. 2016.09; 57 (9): 1728. ( ichushi )

  38. Nakano Satoko, Sugita Sunao, Tomaru Yasuhiro, Nakamuro Takako, Takase Hiroshi, Shimizu Norio, Mochizuki Manabu, Kubota Toshiaki. Establishment of a new comprehensive polymerase chain reaction (PCR) strip kit to diagnose infectious eye diseases INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2016.09; 57 (12):

  39. Kinoshita Shiori, Ishida Takashi, Narita Tomoko, Ito Asahi, Masaki Ayako, Suzuki Susumu, Takino Hisashi, Yoshida Takashi, Ri Masaki, Kusumoto Shigeru, Komatsu Hirokazu, Shimizu Norio, Inagaki Hiroshi, Scholz Arne, Ince Stuart, Ueda Ryuzo, Iida Shinsuke. EBV関連T細胞およびNK細胞リンパ増殖性疾患の治療標的としてのCDK9(CDK9 as a target for treatment in EBV-associated T- and NK-cell lymphoproliferative diseases) 臨床血液. 2016.09; 57 (9): 1541. ( ichushi )

  40. A Arai, C Sakashita, C Hirose, K-I Imadome, M Yamamoto, M Jinta, S Fujiwara, M Tomita, N Shimizu, T Morio, O Miura. Hematopoietic stem cell transplantation for adults with EBV-positive T- or NK-cell lymphoproliferative disorders: efficacy and predictive markers. Bone Marrow Transplant.. 2016.06; 51 (6): 879-882. ( PubMed, DOI )

  41. Au-Yeung Rex K.H., Guo Tianhuan, Chen Yun-Wen, Wong Kai-Yau, Wong Michelle L.Y., Chan Yuen-Piu, Shimizu Norio, Loong Florence, Tse Eric, Kwong Yok-Lam, Srivastava Gopesh. PRDM1のアイソフォームαとβの不均衡な発現は鼻型NK/T細胞リンパ腫の病因に寄与する(Imbalanced expression of a and β isoforms of PRDM1 contributes to the pathogenesis of nasal type NK/T-cell lymphoma) 日本病理学会会誌. 2016.04; 105 (1): 287. ( ichushi )

  42. Natsuko Inazawa, Tsukasa Hori, Masaki Yamamoto, Naoki Hatakeyama, Yuko Yoto, Masanori Nojima, Hiroshi Yasui, Nobuhiro Suzuki, Norio Shimizu, Hiroyuki Tsutsumi. HHV-6 encephalitis may complicate the early phase after allogeneic hematopoietic stem cell transplantation: Detection by qualitative multiplex PCR and subsequent quantitative real-time PCR. J. Med. Virol.. 2016.02; 88 (2): 319-323. ( PubMed, DOI )

  43. Muto T., Takeda Y., Tsukamoto S., Sakai S., Mimura N., Ohwada C., Takeuchi M., Sakaida E., Ota S., Iseki T., Shimizu N., Morio T., Nakaseko C.. Successful treatment of cytomegalovirus enteritis after unrelated allogeneic stem cell transplantation by the infusion of exvivo-expanded CD4(+) lymphocytes derived from the recipient's peripheral blood donor cells TRANSPLANT INFECTIOUS DISEASE. 2016.02; 18 (1): 93-97. ( DOI )

  44. Tomoya Muto, Chikako Ohwada, Atsuko Yamazaki, Yasumasa Sugita, Shokichi Tsukamoto, Shio Sakai, Yusuke Takeda, Naoya Mimura, Masahiro Takeuchi, Emiko Sakaida, Tohru Iseki, Norio Shimizu, Tomohiro Morio, Chiaki Nakaseko. Long-term complete remission by infusion of ex vivo-expanded donor-derived CD4(+) lymphocytes for treating an early relapse of Hodgkin lymphoma after cord blood transplantation. Leuk. Lymphoma. 2016; 57 (1): 230-232. ( PubMed, DOI )

  45. Mayumi Yoshimori, Honami Takada, Ken-Ichi Imadome, Morito Kurata, Kouhei Yamamoto, Takatoshi Koyama, Norio Shimizu, Shigeyoshi Fujiwara, Osamu Miura, Ayako Arai. P-glycoprotein is expressed and causes resistance to chemotherapy in EBV-positive T-cell lymphoproliferative diseases. Cancer Med. 2015.10; 4 (10): 1494-1504. ( PubMed, DOI )

  46. Natsuko Inazawa, Tsukasa Hori, Naoki Hatakeyama, Masaki Yamamoto, Yuko Yoto, Masanori Nojima, Nobuhiro Suzuki, Norio Shimizu, Hiroyuki Tsutsumi. Large-scale multiplex polymerase chain reaction assay for diagnosis of viral reactivations after allogeneic hematopoietic stem cell transplantation. J. Med. Virol.. 2015.08; 87 (8): 1427-1435. ( PubMed, DOI )

  47. Siok-Bian Ng, Koichi Ohshima, Viknesvaran Selvarajan, Gaofeng Huang, Shoa-Nian Choo, Hiroaki Miyoshi, Norio Shimizu, Renji Reghunathan, Hsin-Chieh Chua, Allen Eng-Juh Yeoh, Thuan-Chong Quah, Liang-Piu Koh, Poh-Lin Tan, Wee-Joo Chng. Epstein-Barr virus-associated T/natural killer-cell lymphoproliferative disorder in children and young adults has similar molecular signature to extranodal nasal natural killer/T-cell lymphoma but shows distinctive stem cell-like phenotype. Leuk. Lymphoma. 2015.08; 56 (8): 2408-2415. ( PubMed, DOI )

  48. Yamada H., Tabe Y., Watanabe K., Morishita S., Yuri M., Yokoo M., Horii T., Shimizu N., Kimura S., Ohsaka A.. Harmonization of quantitative BCR-ABL measurements using the secondary reference material anchored to the WHO primary standards INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY. 2015.04; 37 (2): e29-e33. ( DOI )

  49. Yun-Wen Chen, Tianhuan Guo, Lijun Shen, Kai-Yau Wong, Qian Tao, William W L Choi, Rex K H Au-Yeung, Yuen-Piu Chan, Michelle L Y Wong, Johnny C O Tang, Wei-Ping Liu, Gan-Di Li, Norio Shimizu, Florence Loong, Eric Tse, Yok-Lam Kwong, Gopesh Srivastava. Receptor-type tyrosine-protein phosphatase κ directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma. Blood. 2015.03; 125 (10): 1589-1600. ( PubMed, DOI )

  50. H Yagasaki, H Shichino, N Shimizu, T Ohye, H Kurahashi, T Yoshikawa, S Takahashi. Nine-year follow-up in a child with chromosomal integration of human herpesvirus 6 transmitted from an unrelated donor through the Japan Marrow Donor Program. Transpl Infect Dis. 2015.02; 17 (1): 160-161. ( PubMed, DOI )

  51. Ting Wu, Songmei Wang, Jinfeng Wu, Zhiguang Lin, Xianxian Sui, Xiaoping Xu, Norio Shimizu, Bobin Chen, Xuanyi Wang. Icaritin induces lytic cytotoxicity in extranodal NK/T-cell lymphoma. J. Exp. Clin. Cancer Res.. 2015.02; 34 17. ( PubMed, DOI )

  52. Go Matsuda, Ken-ichi Imadome, Fuyuko Kawano, Masashi Mochizuki, Nakaba Ochiai, Tomohiro Morio, Norio Shimizu, Shigeyoshi Fujiwara. Cellular immunotherapy with ex vivo expanded cord blood T cells in a humanized mouse model of EBV-associated lymphoproliferative disease. Immunotherapy. 2015; 7 (4): 335-341. ( PubMed, DOI )

  53. Fuminori Nomura, Taro Sugimoto, Keisuke Kitagaki, Takashi Ito, Hiroshi Kawachi, Yoshinobu Eishi, Ken Watanabe, Miki Igaue, Norio Shimizu, Makoto Tomita, Ken Kitamura, Seiji Kishimoto. Clinical characteristics of Japanese oropharyngeal squamous cell carcinoma positive for human papillomavirus infection. Acta Otolaryngol.. 2014.12; 134 (12): 1265-1274. ( PubMed, DOI )

  54. Inazawa Natsuko, Hori Tsukasa, Yamamoto Masaki, Igarashi Keita, Tsutsumi Hiroyuki, Nojima Masanori, Suzuki Nobuhiro, Shimizu Norio, Hatakeyama Naoki. Multiplex PCR for Virus Infections after Allogeneic Hematopoietic Stem Cell Transplantation BLOOD. 2014.12; 124 (21):

  55. Au-Yeung Rex K.H., Chen Yun-Wen, Guo Tianhuan, Wong Kai-Yau, Shimizu Norio, Tsuchiyama Junjiro, Loong Florence, Kwong Yok-Lam, Srivastava Gopesh. 受容体型タンパク質チロシンホスファターゼκのプロモータの高メチル化はSMILEレジメンで治療を受けた鼻NK/T細胞リンパ腫の患者の好ましくない予後と相関する(Receptor-type protein tyrosine phosphatase kappa promoter hypermethylation correlates with unfavorable prognosis in nasal NK/T-cell lymphoma patients treated with SMILE regimen) 日本病理学会会誌. 2014.09; 103 (2): 37. ( ichushi )

  56. Akifumi Endo, Ken Watanabe, Tamae Ohye, Kyoko Suzuki, Tomoyo Matsubara, Norio Shimizu, Hiroki Kurahashi, Tetsushi Yoshikawa, Harutaka Katano, Naoki Inoue, Kohsuke Imai, Masatoshi Takagi, Tomohiro Morio, Shuki Mizutani. Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency. Clin. Infect. Dis.. 2014.08; 59 (4): 545-548. ( PubMed, DOI )

  57. Shigeyoshi Fujiwara, Hiroshi Kimura, Ken-ichi Imadome, Ayako Arai, Eiichi Kodama, Tomohiro Morio, Norio Shimizu, Hiroshi Wakiguchi. Current research on chronic active Epstein-Barr virus infection in Japan. Pediatr Int. 2014.04; 56 (2): 159-166. ( PubMed, DOI )

  58. Fujiwara Shigeyoshi, Kimura Hiroshi, Imadome Ken-ichi, Arai Ayako, Kodama Eiichi, Morio Tomohiro, Shimizu Norio, Wakiguchi Hiroshi. 日本における慢性活動性Epstein-Barrウイルス感染に関する最新の研究(Current research on chronic active Epstein-Barr virus infection in Japan) Pediatrics International. 2014.04; 56 (2): 159-166. ( ichushi )

  59. Mayumi Yoshimori, Ken-Ichi Imadome, Honami Komatsu, Ludan Wang, Yasunori Saitoh, Shoji Yamaoka, Tetsuya Fukuda, Morito Kurata, Takatoshi Koyama, Norio Shimizu, Shigeyoshi Fujiwara, Osamu Miura, Ayako Arai. CD137 expression is induced by Epstein-Barr virus infection through LMP1 in T or NK cells and mediates survival promoting signals. PLoS ONE. 2014; 9 (11): e112564. ( PubMed, DOI )

  60. Tachikawa R, Tomii K, Seo R, Nagata K, Otsuka K, Nakagawa A, Otsuka K, Hashimoto H, Watanabe K, Shimizu N.. Detection of herpes viruses by multiplex and real-time polymerase chain reaction in bronchoalveolar lavage fluid of patients with acute lung injury or acute respiratory distress syndrome. Respiration. 2014; 87 (4): 279-286. ( PubMed, DOI )

  61. Yan J, Ng SB, Tay JL, Lin B, Koh TL, Tan J, Selvarajan V, Liu SC, Bi C, Wang S, Choo SN, Shimizu N, Huang G, Yu Q, Chng WJ.. EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity. Blood. 2013; 121 4512-4520.

  62. Sugita S, Ogawa M, Shimizu N, Morio T, Ohguro N, Nakai K, Maruyama K, Nagata K, Takeda A, Usui Y, Sonoda KH, Takeuchi M, Mochizuki M.. Use of comprehensive polymerase chain reaction system for dignosis of ocular infectious deseases. Ophthalmol.. 2013; 120 (9): 1761-1768.

  63. Kobayashi Z, Akaza M, Numasawa Y, Ishihara S, Tomimitsu H, Nakamichi K, Saijo M, Morio T, Shimizu N, Sanjo N, Shintani S, Mizusawa H. . Failure of mefloquine therapy in progressive multifocal leukoencephalopathy: Report of two Japanese patients without human immunodeficiency virus infection. J Neurol Sci.. 2013; 324 (1-2): 190-194.

  64. Ito K, Shimizu N, Watanabe K, Saito T, Yoshioka Y, Sakane E, Tsunemine H, Akasaka H, Kodaka T and Takahashi T.. Analysis of viral infection by multiples polymerase chain reaction assays in patients with liver dysfunction. Internal Med.. 2013; 52 (2): 201-211.

  65. Ogawa M, Sugita S, Shimizu N, Watanabe K, Nakagawa I, Mochizuki M.. Broad-range real-time PCR assay for detection of bacterial DNA in ocular samples from infectious endophthalmitis. Jap J Ophthalmol. . 2012; 56 (6): 529-535.

  66. Sugita S, Shimizu N, Watanabe K, Katayama M, Horie S, Ogawa M, Sugimoto Y and Mochizuki M. . Detection of Candida & Aspergillus species DNA using broad-range real-time PCR for fungal endophthalmitis. Graefes Arch Clin Exp Ophthlmol.. 2012; 250 (3): 391-398.

  67. Ogawa M, Sugita S, Watanabe K, Shimizu N, Mochizuki M.. Novel deagnosis of fungal endophthalimitis by broad-range real-time PCR detection of fungal 28S ribosomal DNA. Graefes Arch Clin Exp Ophthlmol. . 2012; 250 (12): 1877-1883.

  68. Sugita S, Shimizu N, Watanabe K, gawa M, Maruyama K, Usui N, Mochizuki M. . Virological analysis in patients with human herpes virus 6-associated ocular inflammatory disorders. Invest Ophth Vis Sci. . 2012; 53 (8): 4692-4698.

  69. Kuwana Y, Takei M, Yajima M, Imadome K, Inomata H, Shiozaki M, Inomata H, Ikumi N, Nozaki T, Shiraiwa H, Kitamura N, Takeuchi J, Sawada S, Yamamoto N, Shimizu N, Ito M and Fujiwara S.. Epstein-Barr Virus Induces Erosive Arthritis in Humanized Mice. PloS ONE.. 2011.08; 6 (10): e26630.

  70. Ramakrishman R, Donahue H, Garcia D, Tan J, Shimizu N, Rice AP, Ling PD. . Epstein-Barr virus BART9 miRNA modulates LMP1 levels and affects growth rate of nasal NK T cell lymphomas. PLoS One. . 2011; e27271.

  71. Sugita S, Shimizu N, Watanabe K, Katayama M, Horie S, Ogawa M, Sugimoto Y and Mochizuki M. . Diagnosis of bacterial endophthalmitis by broad-range quantitative PCR. Br J Ophthalmol.. 2011; 95 345-349.

  72. Karbe K, Nakagawa M, Tsuzuki S, Takeuchi I, Honma K, Nakashima Y, Shimizu N, Ko YH, Morishima Y, Ohshima K, Nakamura S, Seto M. . Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses. Blood.. 2011; 118 (12): 3195-3204.

  73. Ng SB, Selvarajan V, Huang G, Zhou J, Feldman AL, Law M, Kwong YS, Shimizu N, Nagami Y, Aozasa K, Salto-Tellez M and Chng WJ. . Activated oncogenic pathways and therapeutic targets in extranodal nasal-type NK/T cell lymphoma revealed by gene expression profiling. J Phatol.. 2011; 223 (4): 496-510.

  74. Abe T, Segawa Y, Watanabe H, Yotoriyama T, Kai Y, Yasuda A, Shimizu N and Tojo N. . Point-of-Care Testing System Enabling 30-min Detection of Influenza Genes. Lab on a Chip.. 2011; 11 1166-1167.

  75. Yagasaki H, Kato M, Shimizu N, Shichino H, Chin M and Mugishima H. . Autoimmune hemolytic anemia and autoimmune neutropenia in a child with erythroblastopenia of childhood (TEC) caused by human herpesvirus-6 (HHV6). Ann Hematol.. 2011; 90 (7): 851-852.

  76. Watanabe A, Tagawa H, Yamashita J, Teshima K, Nara M, Iwamoto K, Kume M, Kameoka Y, Takahashi N, Nakagawa T, Shimizu N and Sawada K. . The role of microRNA-150 as a tumor suppressor in malignant lymphoma. Leukemia.. 2011; 25 (8): 1324-1334.

  77. Ng SB, Yan J, Huang G, Selvarajan V, Tay J, Lin B, Bi C, Tan J, Kwong YL, Shimizu N, Aozasa K, Chng W. . Dysregulated MicroRNAs Affect Pathways and Targets of Biological Relevance in Nasal-type Natural Killer / T-cell Lymphoma.. Blood. . 2011; 118 (18): 4919-4129.

  78. Imadome K, Yajima M, Arai A, Nakazawa A, Kawano F, Ichikawa S, Shimizu N, Yamamoto N, Morio T, Ohga S, Nakamura H, Ito M, Miura O, Komano J, and Fujiwara S. . Novel Mouse Xenograft Models Reveal a Critical Role of CD4+ T Cells in the Proliferation of EBV-Infected T and NK Cells. PLoS Pathog.. 2011; 7 (10): e1002326.

  79. Miyanaga M, Sugita S, Shimizu N, Morio T, Miyata K, Maruyama K, Kinoshita S, Mochizuki M. . A significant association of viral loads with corneal endothelial cell damage in cytomegalovirus anterior uveitis. Br J Ophthalmol.. 2010; 94 (3): 336-340.

  80. Nagasawa M., Ogawa K., Nagata K and Shimizu N. . Serum granulysin as a possible biomarker of NK cell neoplasm. Br J Haematol.. 2010; 148 (5): 812-814.

  81. Zhang Y, Ohyashiki JH, Shimizu N and Ohyashiki K. . Aberrant expression of NK cell receptors in Epstein-Barr virus-positive gammadelta T-cell lymphoproliferative disorders. Hematology. . 2010; 15 (1): 43-47.

  82. Kariya Y, Hamatake M, Urano E, Yoshiyama H, Shimizu N and Komano J. . Dominant-negative derivative of EBNA1 represses EBNA1-mediated transforming gene expression of Epstein-Barr virus infection independent of rapid loss of viral genome. Cancer Sci. . 2010; 101 (4): 876-881.

  83. Iwata S, Wada K, Tobita S, Gotoh K, Ito Y, Demachi-Okamura A, Shimizu N, Nishiyama Y and Kimura H. . Quantitative Analysis of Epstein-Barr Virus (EBV)-Related Gene Expression in Patients with Chronic Active EBV Infection. J Genl Virol.. 2010; 91 (1): 42-50.

  84. Miyagawa Y, Kiyokawa N, Ochiai N, Imadome K, Horiuchi Y, Onda K, Yajima M, Nakamura H, Katagiri Y, Okita H, Morio T, Shimizu N, Fujimoto J and Fujiwara S.. Ex vivo expanded cord blood CD4 T lymphocytes exhibit a distinct expression profile of cytokine-related genes from those of peripheral blood origin. Immunology.. 2010; 128 (3): 405-419.

  85. Chan KK, Shen L, Au WY, Yuen HF, Wong KY, Guo T, Wong ML, Shimizu N, Tsuchiyama J, Kwong YL, Liang RH and Srivastava G. . Interleukin-2 induces NF-kappaB activation through BCL10 and affects its subcellular localization in natural killer lymphoma cells. J Phatol.. 2010; 221 (2): 164-174.

  86. Miyanaga M, Sugita S, Shimizu N, Morio T, Miyata K, Maruyama K, Kinoshita S, Mochizuki M. . A significant association of viral loads with corneal endothelial cell damage in cytomegalovirus anterior uveitis. Br J Ophthalmol. . 2010; 94 (3): 336-340.

  87. Ono Y, Terashima K, Liu A, Yokoyama M, Yokoshima K, Mizukami M, Watanabe K, Mochimaru Y, Furusaka T, Shimizu N, Yamamoto N, Ishiwata T, Sugisaki Y, Yagi T and Naito Z. . Follicular dendritic cell sarcoma with microtubuloreticular structure and virus-like particle production in vitro. Pathol Int.. 2009; 59 (5): 332-344.

  88. Yajima M, Imadome KI, Nakagawa A, Watanabe S, Terashima K, Nakamura H, Ito M, Shimizu N, Yamamoto N, Fujiwara S. . T Cell-Mediated Control of Epstein-Barr Virus Infection in Humanized Mice. J Infect Dis. . 2009; 200 (10): 1611-1615.

  89. Yamanaka Y, Tagawa H, Takahashi N, Watanabe A, Guo Y-M, Iwamoto K, Yamashita J, Saitoh H, Kameoka Y, Shimizu N, Ichinohasama R, and Sawada K. . Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer–cell lymphoma/leukemia. Blood.. 2009; 114 (15): 3265-3275.

  90. Moriai S, Takahara M, Ogino T, Nagato T, Kishibe K, Ishii H, Katayama A, Shimizu N and Harabuchi Y. . Production of Interferon-γ–Inducible Protein-10 and Its Role as an Autocrine Invasion Factor in Nasal Natural Killer/T-Cell Lymphoma Cells. Clin Cancer Res.. 2009; 15 (22): 6771-6779.

  91. Imadome K, Shimizu N, Yajima M, Watanabe K, Nakamura H, Takeuchi H, Fujiwara S. . CD40 signaling activated by Epstein-Barr virus promotes cell survival and proliferation in gastric carcinoma-derived human epithelial cells. Microbes Infect.. 2009; 11 (3): 429-433.

  92. Kanno H, Watabe D, Shimizu N, Sawai T. . Adhesion of Epstein-Barr virus-positive natural killer cell lines to cultured endothelial cells stimulated with inflammatory cytokines. Clin Exp Immunol.. 2008; 51 (3): 519-927.

  93. Takahashi H, Sugita S, Shimizu N, Mochizuki M. .. A high viral load of Epstein-Barr virus (EBV) DNA in ocular fluids in a HLA-B27 negative acute anterior uveitis patient with psoriasis. Jap J Ophthalmol.. 2008; 52 (2): 136-138.

  94. Sugita S, Shimizu N, Watanabe K, Mizukami, Morio T, Sugamoto Y and Mochizuki M. .. Use of multiplex PCR and real-time PCR to detect human herpes virus genome in ocular fluids of patients with uveitis. Br J Ophthal.. 2008; 92 (7): 928-932.

  95. Kido S, Sugita S, Horie S, Miyanaga M, Miyata K, Shimizu N, Morio T and Mochizuki M. . Association of varicella zoster virus load in the aqueous humor with clinical manifestations of anterior uveitis in herpes zoster ophthalmicus and zoster sine herpete. Br J Ophthal.. 2008; 92 (4): 505-508.

  96. Nakamura H, Ishii C, Suehiro M, Iguchi A, Kuroda K, Shimizu K, Shimizu N, Imadome K, Yajima M and Fujiwara S. . The latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus induces expression of the putative oncogene Bcl-3 through activation of the nuclear factor-kappaB. Virus res.. 2008; 131 (2): 170-179.

  97. Yajima M, Imadome K, Nakagawa A, Watanabe S, Terashima K, Nakamura H, Ito M, Shimizu N, Honda M, Yamamoto N, Fujiwara S. . A new humanized mouse model of Epstein-Barr virus infection that reproduces persistent infection, lymphoproliferative disorder, and cell-mediated and humoral immune responses. J Infect Dis.. 2008; 198 (5): 673-682.

  98. Sugita S, Shimizu N, Kawaguchi T, Akao N, Morio T, Mochizuki M. . Identification of human herpesvirus 6 in a patient with severe unilateral panuveitis. Arch Ophthalmol.. 2007; 125 (10): 1426-1427.

  99. Watanabe S, Terashima K, Ohta S, Horibata S, Yajima M, Shiozawa Y, Dewan Z, Yu Z, Ito M, Morio T, Shimizu N, Honda M, and Yamamoto N. . Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid system and induce long-lasting HIV-1 infection with specific humoral Immune Responses. Blood.. 2007; 109 (1): 212-218.

  100. Kawaguchi T, Sugita S, Shimizu N and Mochizuki M. . Kinetics of aqueous flare, intraocular pressure and virus-DNA copies in a patient with cytomegalovirus iridocyclitis without retinitis. Int Ophthalmol.. 2007; 27 (6): 383-386.

  101. Watanabe S, Ohta S, Yajima M, Terashima K, Ito M, Mugishima H, Fujiwara S, Shimizu K, Honda M, Shimizu N and Yamamoto N. . Humanized NOD/SCID/IL2Rgammanull mice transplanted with hematopoietic stem cell under non-myeloablative condition show prolonged life spans and allow detailed analysis of HIV-1 pathogenesis. J Virol.. 2007; 81 (23): 13259-13264.

  102. Minegishi Y, Saito M, Mori o T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko Ho, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Jo K, Imai K, Kogawa K, Shinohara M, Fujieda Ma, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH , Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S and Karasuyama H. . Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity. Immunity.. 2006; 25 (5): 745-755.

  103. Rouget-Quermalet V, Giustiniani J, Marie-Cardine A, Beaud G, Besnard F, Loyaux D, Ferrara P, Shimizu N, Gaulard P, Bensussan A and Schmitt C. . Protocadherin 15 (PCDH15): a new secreted isoform and a potential marker for NK/T cell lymphomas. Oncogene.. 2006; 25 (19): 2807-2811.

  104. Zhang Y, Ohyashiki JH, Takaku T, Shimizu N, Ohyashiki K. . Transcriptional profiling of Epstein-Barr virus (EBV) genes and host cellular genes in nasal NK/T-cell lymphoma and chronic active EBV infection. Br J Cancer.. 2006; 94 (4): 599-608.

  105. Nagasawa M, Zhu Y, Isoda T, Tomizawa D, Itoh S, Kajiwara M, Morio T, Nonoyama S, Shimizu N and Mizutani S. . Analysis of serum soluble CD40 ligand (sCD40L) in the patients undergoing allogeneic stem cell transplantation: platelet is a major source of serum sCD40L. Eur J Haematol.. 2005; 74 (1): 54-60.

  106. Tomizawa D, Aoki Y, Nagasawa M, Morio T, Kajiwara.M, Sekine T, Shimizu N, Kato M., Yachie A, and Mizutani S. . Adopted immunotherapy for mixed chimerism after unrelated cord blood transplantation using reduced-intensity conditioning in Omenn disease. European J Haematol.. 2005; 75 (5): 441-444.

  107. Imadome K, Shimizu N, Arai A, Miura O, Watanabe K, Nakamura H, Nonoyama S, Yamamoto K, Fujiwara S. . Coexpression of CD40 and CD40 ligand in Epstein-Barr virus-infected T and NK cells and their role in cell survival. J Infect Dis. . 2005; 192 (8): 1340-1348.

  108. Nagato T, Kobayashi H, Kishibe K, Takahara M, Ogino T, Ishii H, Oikawa K, Aoki N, Sato K, Kimura S, Shimizu N, Tateno M, and Harabuchi Y.. Expression of interleukin-9 in nasal natural killer/T-cell lymphoma cell lines and patients. Clin Cancer Res.. 2005; 11 (23): 8250-8257.

  109. Matsuo Y, Drexler HG, Harashima A, Okochi A, Shimizu N, Orita K. . Transcription factor expression in cell lines derived from natural killer-cell and natural killer-like T-cell leukemia-lymphoma. Human Cell.. 2004; 17 (2): 85-92.

  110. Yamaguchi T, Bamba K, Kitayama A, Kuroiwa Y, Ogawa K, Sekine T, Shimizu N, Yamamoto N. . Long-term intravenous administration of activated autologous lymphocytes for cancer patients does not induce anti-nuclear antibody and rheumatoid factor. Anticancer Res. . 2004; 24 (4): 2423-2429.

  111. Demachi A, Nagata H, Morio T, Oyoshi MK, Zhang Y, Tabata N, Kimura N, Shimizu N and Yamamoto K. . Characterization of Epstein-Barr virus (EBV)-positive NK cells isolated from hydroa vacciniforme-like eruptions. Microbiol Immunol.. 2003; 47 (7): 543-552.

  112. Oyoshi MK, Nagata H, Kimura N, Zhang Y, Demachi A, Hara T, Kanegane H, Matsuo Y, Yamaguchi T, Morio T, Hirano A, Shimizu N, and Yamamoto K. . Preferential expansion of Vgamma9-JgammaP/Vdelta2-Jdelta3 ganmmadelta T-cells in nasal T-cell lymphoma and chronic active Epstein-Barr virus (EBV) infection. Am J Pathol.. 2003; 162 (5): 1629-1638.

  113. Zhang Y, Nagata H, Ikeuchi T, Mukai H, Ohyoshi MK, Demachi A, Morio T, Wakiguchi H, Kimura N, Shimizu N, and Yamamoto K. . Common cytological and cytogenetic features of Epstein-Barr virus (EBV)-positive natural killer (NK) cells and cell lines derived from patients with nasal T/NK-cell lymphomas, chronic active EBV infection and hydroa vacciniforme-like eruptions. Br J Haematol.. 2003; 121 (5): 805-814.

  114. Imadome K, Shirakata M, Shimizu N, Nonoyama S and YamanashiY. . CD40 ligand is a critical effector of Epstein-Barr virus in host cell survival and transformation. Proc Natl Acad Sci U S A.. 2003; 100 (13): 7836-7840.

  115. Shen L, Liang AC, Lu L, Au WY, Wong KY, Tin PC, Chan KW, Ko KH, Chen YW, Beh SL, Shimizu N, Tsuchiyama J, Tang JC, Kwong YL, Liang RH and Srivastava G. . Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma. Blood.. 2003; 102 (4): 1553-1554.

  116. Yanai H, Kuroiwa Y, Shimizu N, Matsubara Y, Okamoto T, Hirano A, Nakamura Y, Okita K and Sekine T.. The pilot experience of immunotherapy-cobined photodynamic therapy for advanced gastric cancer in elderly patients. Int J Gastrointes Cancer.. 2002; 32 (2-3): 139-142.

  117. Aritaki K, Ohyashiki JH, Suzuki A, Ojima T, Abe K, Shimizu N, Yamamoto K, Ohyashiki K and Hoshika A. . A rapid monitaring system of human herpesviruses reactivation by LightCycler in stem cell transplantation. Bone Marrow Transplant.. 2001; 28 (10): 975-980.

  118. Nagata H, Konno A, Kimura N, Zhang Y, Kimura M, Demachi A, Sekine T, Yamamoto K and Shimizu N. . Characterization of Novel Natural Killer (NK)-Cell and gamma/delta T-Cell Lines Established from Primary Lesions of Nasal T/NK Cell Lymphomas Associated with the Epstein-Barr Virus. Blood.. 2001; 97 (3): 708-713.

  119. Nagata H, Numata T, Konno A, Mikata I, Kurasawa K, Hara S, Nishimura M, Yamamoto K and Shimizu N. . Presence of natural killer-cell clones with variable proliferative capacity in chronic active Epstein-Barr virus infection. Pathol Int.. 2001; 51 (10): 778-785.

  120. Shimizu N, Sekine T, Itoh K, Nakamura T, Iwamoto A, Satoh Y and Yamamoto K.. Large-scale ex vivo expansion of primary T-lymphocytes in late-stage AIDS patients. AIDS Res Hum Retroviruses.. 2000; 16 (6): 611-612.

  121. Yanai H, Murakami T, Yoshimura H, Takeuchi H, Nishikawa J, Nakamura H, Okita K, Mirura O, Shimizu N and Takeda K. . Epstein-Barr virus-associated gastric carcinoma and atrophic gastritis. J Clin Gastroenterol.. 1999; 29 (1): 39-43.

  122. Yanai H, Shimizu N, Nagasaki S, Mitani N and Okita K. . Epstein-Barr virus infection of the colon with inflammatory bowel disease. Am J Gastroenterol.. 1999; 94 (6): 1582-1586.

  123. Yoshiyama H, Imai S, Shimizu N and Takada K. . Epstein-Barr virus infection of human gastric carcinoma cells: Implication of the existance of a new virus receptor different from CD21. J Virol.. 1997; 71 (7): 5688-5691.

  124. Yanai H, Nishikawa J, Mizugaki Y, Shimizu N, Takada K, Matusaki K, Toda T, Matsumoto Y, Tada M and Okita K.. Endoscopic and pathologic features of Epstein-Barr virus-associated gastric carcinoma. Gastrointest Endosc.. 1997; 45 (3): 236-242.

  125. Yanai H, Takada K, Shimizu N, Mizugaki Y, Tada M and Okita K. . Epstein-Barr virus infection in non-carcinomatous gastric epithelium. J Pathol. . 1997; 183 (3): 293-298.

  126. Wen S, Shimizu N, Yoshiyama H, Mizugaki Y, Shinozaki F and Takada K. . Association of EBV with Sjogren's syndrome: differential EBV expression between epithelial cells and lymphocytes in salivary glands. Am J Pathol .. 1996; 149 (5): 1511-1517.

  127. Shimizu N, Yoshiyama H and Takada K. . Clonal propagation of Epstein-Barr virus (EBV) recombinants in EBV-negative Akata cells. J Virol.. 1996; 70 (10): 7260-7263.

  128. Takada K, Shimizu N, Tanabe-Tochikura A and Kuroiwa Y. . Pathogenic role of Epstein-Barr virus in human cancer. Intervirol.. 1995; 38 (3-4): 214-220.

  129. Yoshiyama H, Shimizu N and Takada K. . Persistent Epstein-Barr virus infection in a human T-cell line: unique program of latent virus expression. EMBO J.. 1995; 14 (15): 3706-3711.

  130. Shimizu N, Tanabe-Tochikura A, Kuroiwa Y and Takada K. . Isolation of Epstein-Barr virus (EBV)-negative cell clones from an EBV-positive Burkitt's lymphoma(BL) line Akata:Malignant phenotypes of BL cells dependent on Epstein-Barr virus. J Virol.. 1994; 68 (9): 6069-6073.

  131. Shimizu N and Takada K. . Analysis of the BZLF1 promoter of Epstein-Barr virus: Identification of an anti-immunoglobulin response sequence. J Virol.. 1993; 67 (6): 3240-3245.

  132. Takada K, Ji Z, Fujiwara S, Shimizu N and Tochikura AT. . Partial elimination of Epstein-Barr virus plasmids from Burkitt's lymphoma cells by transfecting the BZLF1 gene. J Virol.. 1992; 66 (9): 5590-5593.

  133. Shimizu N, Sakuma S, Ono Y and Takada K.. Identification of an enhancer-type sequence that is responsive to Z and R trans-activators of Epstein-Barr virus. Virology. . 1989; 172 (2): 655-658.

  134. Shimizu N, Yamaki M, Sakuma S, Ono Y and Takada K. . Three Epstein-Barr virus (EBV)-determined nuclear antigens induced by the BamHI E region of EBV DNA. Int J Cancer.. 1988; 41 (5): 744-751.

  135. Oguro MO, Shimizu N, Ono Y and Takada K. . Both the rightward and leftward open reading frames within the BamHI M DNA fragment of Epstein-Barr virus act as trans-activators of gene expression. J Virol.. 1987; 61 (10): 3310-3313.

  136. Takada K, Shimizu N, Oguro M and Ono Y. . Identification of cording regions for various Epstein-Barr virus-specific antigens by gene transfer and serology. J Virol.. 1986; 60 (1): 324-330.

  137. Takada K, Shimizu N, Sakuma S and Ono Y. . trans activation of latent Epstein-Barr virus (EBV) genome after transfection of the EBV DNA fragment. J Virol. . 1986; 57 (3): 1016-1022.

  138. Ohori H, Shimizu N, Yamada E, Onodera S and Ishida N. . Immunological and morphological properties of HBeAg subtypes (HBeAg/1 and HBeAg/2) in Hepatitis B virus core particles. J Gen Virol.. 1984; 65 (Pt2): 405-414.

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Conference Activities & Talks 【 display / non-display

  1. Yoshimori M, Shixing Wu, Tateishi M, Ohashi A, Shimizu N, Imadome K, Arai A. The expression and function of EBV-derived micro-RNA in chronic active EBV infection(慢性活動性EBウイルス感染症におけるウイルス由来マイクロRNAの発現と機能). 第81回日本血液学会学術集会 2019.10.11 東京

  2. Haruna Shibayama, Ken-ichi Imadome, Chizuko Sakashita, Ken Watanabe, Fuyuko Kawano, Norio Shimizu, Takatoshi Koyama, Shigeyoshi Fujiwara, Osamu Miura, Ayako Arai. In vitro and in vivo effects of bortezomib on EBV-T/NK-LPDs. The 78th Annual Meeting of the Japanese Society of Hematology 2016.10.14 Yokohama

  3. Haruna Shibayama, Ken-ichi Imadome, Chizuko Sakashita, Ken Watanabe, Norio Shimizu, Takatoshi Koyama, Shigeyoshi Fujiwara, Osamu Miura, Ayako Arai. In vitro and in vivo effects of proteasome inhibitor bortezomib on Epstein-Barr virus-positive T- or NK-cell lymphoproliferative diseases. 17th International Symposium on Epstein-Barr virus (EBV) and Associated Diseases 2016.08.10 Zurich

Patents 【 display / non-display

  • METHOD FOR DETECTING AND QUANTIFYING TARGET NUCLEIC ACID IN TEST SAMPLE USING NOVEL POSITIVE CONTROL NUCLEIC ACID

    Patent Number: EP3208333

  • METHOD FOR DETECTING MYCOPLASMA

    Patent Number: US10640834

  • METHOD FOR DETECTING MYCOPLASMA

    Patent Number: 3192878