Personnel Information

写真a

OSAKA Mizuko


Job title

Assistant Professor

Mail Address

mizu.vasc@tmd.ac.jp

Graduating School 【 display / non-display

  • Tokyo University of Science, Faculty of Engineering Science, biological science and technology, 1994.03, Graduated

Degree 【 display / non-display

  • PhD, Tokyo Medical and Dental University

Campus Career 【 display / non-display

  • 2010.04
    -
    2011.03
    Tokyo Medical and Dental University, Joint Institutes for Education and Research, Life Science and Bioethics Research Center, Department of Life Sciences and Medical Ethics, Project Assistant Professor
  • 2011.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Public Health, Life Sciences and Bioethics, Assistant Professor
  • 2014.10
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    2017.03
    Tokyo Medical and Dental University, Research and Industry-University Alliance Organization, Life Science and Bioethics Research Center, Assistant Professor
  • 2014.10
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Endowed Departments, Department of Nutrition and Metabolism in Cardiovascular Disease, Project Assistant Professor
  • 2017.04
     
     
    Tokyo Medical and Dental University, Institute of Research, Research Facility Cluster, Life Science and Bioethics Research Center, Assistant Professor

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Research Areas 【 display / non-display

  • General medical chemistry

 

Published Papers & Misc 【 display / non-display

  • Mizuko Osaka, Shunsuke Ito, Masaki Honda, Yukihiro Inomata, Kensuke Egashira, Masayuki Yoshida. Critical role of the C5a-activated neutrophils in high-fat diet-induced vascular inflammation. Scientific Reports. 2016.02; 6 21391. ( PubMed, DOI )

  • Higashijima Y, Matsui Y, Shimamura T, Nakaki R, Nagai N, Tsutsumi S, Abe Y, Link VM, Osaka M, Yoshida M, Watanabe R, Tanaka T, Taguchi A, Miura M, Ruan X, Li G, Inoue T, Nangaku M, Kimura H, Furukawa T, Aburatani H, Wada Y, Ruan Y, Glass CK, Kanki Y. Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells. The EMBO journal. 2020.03; e103949. ( PubMed, DOI )

  • Nishi H., Inoue R., Osaka M., Inoue T., Yoshida M., Nangaku M.. Neutrophil interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) mediates vascular adhesion and transmigration in non-viral inflammatory disease EUROPEAN JOURNAL OF IMMUNOLOGY. 2019.10; 49 582.

  • Dewan Syed Masudur Rahman, Shiraishi Orie, Deushi Michiyo, Tani Mariko, Osaka Mizuko, Yoshida Masayuki. C5aによる好中球β2インテグリン活性化はPKCδの膜移行に関与する(C5a-induced β2 integrin activation in neutrophils involves membrane translocation of PKC δ) 日本動脈硬化学会総会プログラム・抄録集. 2019.07; 51回 2-P. ( ichushi )

  • Tani M, Kamata Y, Deushi M, Osaka M, Yoshida M.. 7-Ketocholesterol enhances leukocyte adhesion to endothelial cells via p38MAPK pathway. PLoS One. 2018.06; 13 (7): e0200499. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  • Mizuko Osaka. Mechanism of vascular inflammation in LDLR null mice by PAD4-induced citrullination. The 51st Annual Scientific Meeting of the Japan Atherosclerosis Society 2019.07.16

  • Syed Masudur Rahman Dewan, Mizuko Osaka, Masayuki Yoshida. C5a induces PKC dependent β2 integrin activation in neutrophil-like differentiated HL-60.. 第四回J-ISCP年次学術集会 国際心血管薬物療法学会日本部会 2019.06.08

  • Hiromi Tsuru, Mizuko Osaka, Masayuki Yoshida. The effect of complement factor D (FD) on the development of non-alcoholic fatty liver disease (NAFLD). Cardiovascular and Metabolic Week 2018 2018.12.07

  • Mizuko Osaka. Curcial role of neutrophil-citrullination on high-fat diet-induced vasuclar inflammation. The 41st Annual Meeting of the Molecular Biology Society of Japan 2018.11.12

  • Syed Masudur Rahman Dewan, Mizuko Osaka, Masayuki Yoshida. Complement component C5a induces qualitative change on neutrophil-endothelial interaction under physiological flow condition. 第16回日韓血管生物合同シンポジウム 2018.09.14

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