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Graduating School 【 display / non-display 】
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Tokyo University of Science, Faculty of Engineering Science, biological science and technology, 1994.03, Graduated
Degree 【 display / non-display 】
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PhD, Tokyo Medical and Dental University
Campus Career 【 display / non-display 】
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2010.04-2011.03Tokyo Medical and Dental University， Joint Institutes for Education and Research， Life Science and Bioethics Research Center， Department of Life Sciences and Medical Ethics， Project Assistant Professor
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2011.04-NowTokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Public Health， Life Sciences and Bioethics， Assistant Professor
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2014.10-2017.03Tokyo Medical and Dental University， Research and Industry-University Alliance Organization， Life Science and Bioethics Research Center， Assistant Professor
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2014.10-NowTokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Endowed Departments， Department of Nutrition and Metabolism in Cardiovascular Disease， Project Assistant Professor
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2017.04Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Life Science and Bioethics Research Center， Assistant Professor
Published Papers & Misc 【 display / non-display 】
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Mizuko Osaka, Shunsuke Ito, Masaki Honda, Yukihiro Inomata, Kensuke Egashira, Masayuki Yoshida. Critical role of the C5a-activated neutrophils in high-fat diet-induced vascular inflammation. Scientific Reports. 2016.02; 6 21391. ( PubMed, DOI )
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Higashijima Y, Matsui Y, Shimamura T, Nakaki R, Nagai N, Tsutsumi S, Abe Y, Link VM, Osaka M, Yoshida M, Watanabe R, Tanaka T, Taguchi A, Miura M, Ruan X, Li G, Inoue T, Nangaku M, Kimura H, Furukawa T, Aburatani H, Wada Y, Ruan Y, Glass CK, Kanki Y. Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells. The EMBO journal. 2020.03; e103949. ( PubMed, DOI )
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Nishi H., Inoue R., Osaka M., Inoue T., Yoshida M., Nangaku M.. Neutrophil interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2) mediates vascular adhesion and transmigration in non-viral inflammatory disease EUROPEAN JOURNAL OF IMMUNOLOGY. 2019.10; 49 582.
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Dewan Syed Masudur Rahman, Shiraishi Orie, Deushi Michiyo, Tani Mariko, Osaka Mizuko, Yoshida Masayuki. C5aによる好中球β2インテグリン活性化はPKCδの膜移行に関与する(C5a-induced β2 integrin activation in neutrophils involves membrane translocation of PKC δ) 日本動脈硬化学会総会プログラム・抄録集. 2019.07; 51回 2-P. ( ichushi )
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Tani M, Kamata Y, Deushi M, Osaka M, Yoshida M.. 7-Ketocholesterol enhances leukocyte adhesion to endothelial cells via p38MAPK pathway. PLoS One. 2018.06; 13 (7): e0200499. ( PubMed, DOI )
Conference Activities & Talks 【 display / non-display 】
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Syed Masudur Rahman Dewan, Michiyo Deushi, Mizuko Osaka, Masayuki Yoshida. C5a elevates MCP-1 expression in neutrophil-like differentiated HL60 via NF-κB signaling pathway. 第84回日本循環器学会学術集会 2020.07.27 京都
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Hiromi Tsuru, Mizuko Osaka, Masayuki Yoshida. Critical Role of Complement Factor D in the Development of High-fat Diet-induced Fatty Liver . 第84回日本循環器学会学術集会 2020.07.27 Kyoto
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大坂 瑞子、出牛 三千代、吉田 雅幸. 選択的PPARaアゴニスト、ペマフィブラートはLDL受容体欠損マウス大腿動脈における高中性脂肪血症を改善し、白血球接着を抑制する. 第52回日本動脈硬化学会総会・学術集会 2020.07.17 名古屋
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Mizuko Osaka, Masayuki Yoshida. The involvement of neutrophil extracellular traps in HFD-induced vascular inflammation in LDLR null mice. Cardiovascular and Metabolic Week 2019 2019.12.14
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Shwd Masudur Rahman Dewan, Michiyo Deushi, Mizuko Osaka, Masayuki Yoshida. C5a induces NFkB dependent MCP-1 expression in neutrophil-like differentiated HL60. 2019.12.14 神戸