Personnel Information

写真a

OSAKA Mizuko


Job title

Assistant Professor

Mail Address

mizu.vasc@tmd.ac.jp

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Graduating School 【 display / non-display 】

  • Tokyo University of Science, Faculty of Engineering Science, biological science and technology, 1994.03, Graduated

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Degree 【 display / non-display 】

  • PhD, Tokyo Medical and Dental University

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Campus Career 【 display / non-display 】

  • 2010.04
    -
    2011.03
    Tokyo Medical and Dental University， Joint Institutes for Education and Research， Life Science and Bioethics Research Center， Department of Life Sciences and Medical Ethics， Project Assistant Professor
  • 2011.04
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Public Health， Life Sciences and Bioethics， Assistant Professor
  • 2014.10
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    2017.03
    Tokyo Medical and Dental University， Research and Industry-University Alliance Organization， Life Science and Bioethics Research Center， Assistant Professor
  • 2014.10
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Endowed Departments， Department of Nutrition and Metabolism in Cardiovascular Disease， Project Assistant Professor
  • 2017.04
    　
    　
    Tokyo Medical and Dental University， Institute of Research， Research Facility Cluster， Life Science and Bioethics Research Center， Assistant Professor

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Research Areas 【 display / non-display 】

  • General medical chemistry

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Published Papers & Misc 【 display / non-display 】

  • Osaka M, Deushi M, Aoyama J, Funakoshi T, Ishigami A, Yoshida M. High-Fat Diet Enhances Neutrophil Adhesion in LDLR-Null Mice Via Hypercitrullination of Histone H3. JACC. Basic to translational science. 2021.06; 6 (6): 507-523. ( PubMed, DOI )

  • Mizuko Osaka, Shunsuke Ito, Masaki Honda, Yukihiro Inomata, Kensuke Egashira, Masayuki Yoshida. Critical role of the C5a-activated neutrophils in high-fat diet-induced vascular inflammation. Scientific Reports. 2016.02; 6 21391. ( PubMed, DOI )

  • Dewan SMR, Osaka M, Deushi M, Yoshida M. Complement C5a-triggered differentiated HL-60 stimulates migration of THP-1 monocytic leukocytes via secretion of CCL2. FEBS open bio. 2021.05; 11 (5): 1374-1381. ( PubMed, DOI )

  • Tsuru Hiromi, Osaka Mizuko, Yoshida Masayuki. Complement Factor D Facilitates the Development of Fatty Liver under Long-term but not Short-term High-fat Diet-feeding Conditions(和訳中) 日本循環器学会学術集会抄録集. 2021.03; 85回 OE113-3. ( ichushi )

  • Dewan Syed Masudur Rahman, Osaka Mizuko, Deushi Michiyo, Yoshida Masayuki. C5a-stimulated Neutrophil-like Differentiated HL-60 Induced Migration of Monocytic THP-1 through the Secretion of MCP-1(和訳中) 日本循環器学会学術集会抄録集. 2021.03; 85回 OE029-5. ( ichushi )

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Conference Activities & Talks 【 display / non-display 】

  • 大坂瑞子. 動脈硬化症関連血管炎症反応における好中球でのヒストンシトルリン化の重要性. 第43回日本分子生物学会年会 2020.12.02

  • Syed Masudur Rahman Dewan, Michiyo Deushi, Mizuko Osaka, Masayuki Yoshida. C5a elevates MCP-1 expression in neutrophil-like differentiated HL60 via NF-κB signaling pathway. 第84回日本循環器学会学術集会 2020.07.27 京都

  • Hiromi Tsuru, Mizuko Osaka, Masayuki Yoshida. Critical Role of Complement Factor D in the Development of High-fat Diet-induced Fatty Liver . 第84回日本循環器学会学術集会 2020.07.27 Kyoto

  • 大坂　瑞子、出牛　三千代、吉田　雅幸. 選択的PPARaアゴニスト、ペマフィブラートはLDL受容体欠損マウス大腿動脈における高中性脂肪血症を改善し、白血球接着を抑制する. 第52回日本動脈硬化学会総会・学術集会 2020.07.17 名古屋

  • Mizuko Osaka, Masayuki Yoshida. The involvement of neutrophil extracellular traps in HFD-induced vascular inflammation in LDLR null mice. Cardiovascular and Metabolic Week 2019 2019.12.14

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