Personnel Information

写真a

SOHARA Eisei


Job title

Associate Professor

Campus Career 【 display / non-display

  • 1900.01
    -
    2015.11
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Nephrology, Junior Associate Professor
  • 2008.04
    -
    2018.03
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Nephrology, Associate Professor
  • 2015.11
    -
    2016.02
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Nephrology, Associate Professor
  • 2018.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Nephrology, Associate Professor

Research Areas 【 display / non-display

  • Nephrology

 

Published Papers & Misc 【 display / non-display

  1. Nanamatsu Azuma, Mori Takayasu, Ando Fumiaki, Furusho Taisuke, Mandai Shintaro, Susa Koichiro, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi. Vasopressin Induces Urinary Uromodulin Secretion By Activating PKA (Protein Kinase A) HYPERTENSION. 2021.06; 77 (6): 1953-1963. ( DOI )

  2. Takahashi Naohiro, Kikuchi Hiroaki, Usui Ayaka, Furusho Taisuke, Fujimaru Takuya, Fujiki Tamami, Yanagi Tomoki, Matsuura Yoshiaki, Asano Kenichi, Yamamoto Kouhei, Ando Fumiaki, Susa Koichiro, Mandai Shintaro, Mori Takayasu, Rai Tatemitsu, Uchida Shinichi, Arita Makoto, Sohara Eisei. Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD(2) in the kidney CLINICAL AND EXPERIMENTAL NEPHROLOGY. 2021.05; 25 (5): 445-455. ( DOI )

  3. Takuya Fujimaru, Kunio Kawanishi, Takayasu Mori, Eikan Mishima, Akinari Sekine, Motoko Chiga, Masayuki Mizui, Noriaki Sato, Motoko Yanagita, Yuki Ooki, Kiyotaka Nagahama, Yuko Ohnuki, Naoto Hamano, Saki Watanabe, Toshio Mochizuki, Katsushi Nagatsuji, Kenichi Tanaka, Tatsuo Tsukamoto, Hideo Tsushima, Mamiko Shimamoto, Takahiro Tsuji, Tamaki Kuyama, Shinya Kawamoto, Kenji Maki, Ai Katsuma, Mariko Oishi, Kouhei Yamamoto, Shintaro Mandai, Hiroaki Kikuchi, Fumiaki Ando, Yutaro Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Tatemitsu Rai, Junichi Hoshino, Yoshifumi Ubara, Mariko Miyazaki, Michio Nagata, Shinichi Uchida, Eisei Sohara. Genetic Background and Clinicopathologic Features of Adult-onset Nephronophthisis. Kidney Int Rep. 2021.05; 6 (5): 1346-1354. ( PubMed, DOI )

  4. Mori Takayasu, Chiga Motoko, Fujimaru Takuya, Kawamoto Ryosuke, Mandai Shintaro, Nanamatsu Azuma, Nomura Naohiro, Ando Fumiaki, Susa Koichiro, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi. Phenotypic differences of mutation-negative cases in Gitelman syndrome clinically diagnosed in adulthood HUMAN MUTATION. 2021.03; 42 (3): 300-309. ( DOI )

  5. Arai Yohei, Asano Kenichi, Mandai Shintaro, Ando Fumiaki, Susa Koichiro, Mori Takayasu, Nomura Naohiro, Rai Tatemitsu, Tanaka Masato, Uchida Shinichi, Sohara Eisei. WNK1-TAK1 signaling suppresses lipopolysaccharide-induced cytokine production and classical activation in macrophages BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2020.12; 533 (4): 1290-1297. ( DOI )

  6. Umene Ryusuke, Kitamura Mineaki, Arai Hideyuki, Matsumura Kazuki, Ishimaru Yuka, Maeda Kanenori, Uramatsu Tadashi, Obata Yoko, Mori Takayasu, Sohara Eisei, Uchida Shinichi, Nishino Tomoya. Bartter syndrome representing digenic-based salt-losing tubulopathies presumably accelerated by renal insufficiency(和訳中) CEN Case Reports. 2020.11; 9 (4): 375-379. ( ichushi )

  7. Sekine Akinari, Hoshino Junichi, Fujimaru Takuya, Suwabe Tatsuya, Mizuno Hiroki, Kawada Masahiro, Hiramatsu Rikako, Hasegawa Eiko, Yamanouchi Masayuki, Hayami Noriko, Mandai Shintaro, Chiga Motoko, Kikuchi Hiroaki, Ando Fumiaki, Mori Takayasu, Sohara Eisei, Uchida Shinichi, Sawa Naoki, Takaichi Kenmei, Ubara Yoshifumi. Genetics May Predict Effectiveness of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease AMERICAN JOURNAL OF NEPHROLOGY. 2020.09; 51 (9): 745-751. ( DOI )

  8. Furusho Taisuke, Uchida Shinichi, Sohara Eisei. The WNK signaling pathway and salt-sensitive hypertension HYPERTENSION RESEARCH. 2020.08; 43 (8): 733-743. ( DOI )

  9. Mishima Eikan, Mori Takayasu, Nakajima Yoko, Toyohara Takafumi, Kikuchi Koichi, Oikawa Yoshitsugu, Matsuhashi Tetsuro, Maeda Yasuhiro, Suzuki Takehiro, Kudo Masataka, Ito Sadayoshi, Sohara Eisei, Uchida Shinichi, Abe Takaaki. 家族性若年性痛風を呈したHPRT1の新規p.V35M変異を伴うHPRT関連高尿酸血症(HPRT-related hyperuricemia with a novel p.V35M mutation in HPRT1 presenting familial juvenile gout) CEN Case Reports. 2020.08; 9 (3): 210-214. ( ichushi )

  10. Furusho Taisuke, Uchida Shinichi, Sohara Eisei. WNKシグナル伝達経路と食塩感受性高血圧(The WNK signaling pathway and salt-sensitive hypertension) Hypertension Research. 2020.08; 43 (8): 733-743. ( ichushi )

  11. Tsuji Kiyokazu, Kitamura Mineaki, Muta Kumiko, Mochizuki Yasushi, Mori Takayasu, Sohara Eisei, Uchida Shinichi, Sakai Hideki, Mukae Hiroshi, Nishino Tomoya. Transplantation of a kidney with a heterozygous mutation in the SLC22A12 (URAT1) gene causing renal hypouricemia: a case report BMC NEPHROLOGY. 2020.07; 21 (1): ( DOI )

  12. Shoda Wakana, Nomura Naohiro, Ando Fumiaki, Tagashira Hideaki, Iwamoto Takahiro, Ohta Akihito, Isobe Kiyoshi, Mori Takayasu, Susa Koichiro, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi. Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia PLOS ONE. 2020.06; 15 (6): ( DOI )

  13. Fujimaru Takuya, Sohara Eisei. Copy Number Variation: A New Genetic Form of Polycystic Kidney and Liver Disease KIDNEY INTERNATIONAL REPORTS. 2020.05; 5 (5): 575-576. ( DOI )

  14. Furusho Taisuke, Sohara Eisei, Mandai Shintaro, Kikuchi Hiroaki, Takahashi Naohiro, Fujimaru Takuya, Hashimoto Hiroko, Arai Yohei, Ando Fumiaki, Zeniya Moko, Mori Takayasu, Susa Koichiro, Isobe Kiyoshi, Nomura Naohiro, Yamamoto Kohei, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi. Renal TNF alpha activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease KIDNEY INTERNATIONAL. 2020.04; 97 (4): 713-727. ( DOI )

  15. Saran Sinha Adya, Wang Tianying, Hosoi Yasushi, Sohara Eisei, Akita Tenpei, Uchida Shinichi, Fukuda Atsuo. WNK3 kinase maintains basal excitability by regulating inward rectification and intracellular chloride in layer V pyramidal neurons of mouse medial prefrontal cortex(和訳中) The Journal of Physiological Sciences. 2020.03; 70 (Suppl.1): S157. ( ichushi )

  16. Mandai S, Sato H, Iimori S, Naito S, Tanaka H, Ando F, Susa K, Isobe K, Mori T, Nomura N, Sohara E, Okado T, Uchida S, Fushimi K, Rai T. Nationwide in-hospital mortality following major fractures among hemodialysis patients and the general population: An observational cohort study. Bone. 2020.01; 130 115122. ( PubMed, DOI )

  17. Chinen T, Saeki E, Mori T, Sohara E, Uchida S, Akimoto T. A case of Gitelman syndrome: our experience with a patient treated in clinical practice on a local island. Journal of rural medicine : JRM. 2019.11; 14 (2): 258-262. ( PubMed, DOI )

  18. Furuto Y, Kawamura M, Namikawa A, Takahashi H, Shibuya Y, Mori T, Sohara E. Non-urate transporter 1, non-glucose transporter member 9-related renal hypouricemia and acute renal failure accompanied by hyperbilirubinemia after anaerobic exercise: a case report. BMC nephrology. 2019.11; 20 (1): 433. ( PubMed, DOI )

  19. Akihisa T, Sato M, Wakayama Y, Taneda S, Horita S, Hirose O, Makabe S, Kataoka H, Mori T, Sohara E, Uchida S, Nitta K, Mochizuki T. Glomerular Basement Membrane Protein Expression and the Diagnosis and Prognosis of Autosomal Dominant Alport Syndrome. Kidney medicine. 2019.11; 1 (6): 391-396. ( PubMed, DOI )

  20. Matsuura Y, Nomura N, Shoda W, Mori T, Isobe K, Susa K, Ando F, Sohara E, Rai T, Uchida S. Tacrolimus ameliorates the phenotypes of type 4 Bartter syndrome model mice through activation of sodium-potassium-2 chloride cotransporter and sodium-chloride cotransporter. Biochemical and biophysical research communications. 2019.09; 517 (2): 364-368. ( PubMed, DOI )

  21. Sakoh T, Sekine A, Mori T, Mizuno H, Kawada M, Hiramatsu R, Hasegawa E, Hayami N, Yamanouchi M, Suwabe T, Sawa N, Ubara Y, Fujimaru T, Sohara E, Shinichi U, Hoshino J, Takaichi K. A familial case of pseudohypoaldosteronism type II (PHA2) with a novel mutation (D564N) in the acidic motif in WNK4. Molecular genetics & genomic medicine. 2019.06; 7 (6): e705. ( PubMed, DOI )

  22. Fujiki T, Ando F, Murakami K, Isobe K, Mori T, Susa K, Nomura N, Sohara E, Rai T, Uchida S. Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation. Scientific reports. 2019.06; 9 (1): 9245. ( PubMed, DOI )

  23. Ohkubo A, Okado T, Sakurasawa T, Maeda T, Itagaki A, Yamamoto H, Miyamoto S, Seshima H, Kurashima N, Mori T, Iimori S, Sohara E, Rai T, Uchida S, Naito S. Removal Characteristics of Immunoadsorption with the Tryptophan-Immobilized Column Using Conventional and Selective Plasma Separators in the Treatment of Myasthenia Gravis. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2019.06; 23 (3): 271-278. ( PubMed, DOI )

  24. Suzuki Soichiro, Naito Shotaro, Numasawa Yoshiyuki, Asada Mizuho, Shoji Norikazu, Zeniya Moko, Takahashi Daiei, Sato Hidehiko, Iimori Soichiro, Nomura Naohiro, Sohara Eisei, Okado Tomokazu, Ishiwata Yasuyoshi, Nagata Masashi, Rai Tatemitsu, Yokota Takanori, Uchida Shinichi. Encephalopathy Induced by High Plasma and Cerebrospinal Fluid Ceftriaxone Concentrations in a Hemodialysis Patient(和訳中) Internal Medicine. 2019.06; 58 (12): 1775-1779. ( ichushi )

  25. Ohkubo Atsushi, Okado Tomokazu, Sakurasawa Takatoshi, Maeda Takuma, Itagaki Ayako, Yamamoto Hiroko, Miyamoto Satoko, Seshima Hiroshi, Kurashima Naoki, Mori Takayasu, Iimori Soichiro, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi, Naito Shotaro. Removal Characteristics of Immunoadsorption with the Tryptophan-Immobilized Column Using Conventional and Selective Plasma Separators in the Treatment of Myasthenia Gravis(和訳中) Therapeutic Apheresis and Dialysis. 2019.06; 23 (3): 271-278. ( ichushi )

  26. Sohara Eisei, Kikuchi Hiroaki, Uchida Shinichi. 腎機能の再生医療におけるNew Frontiers 慢性腎臓病におけるエネルギー状態感知不全(New Frontiers in Regenerative Medicine of Renal Function Failure to sense energy depletion in chronic kidney disease) The Journal of Physiological Sciences. 2019.06; 69 (Suppl.1): S56. ( ichushi )

  27. Tanaka T, Oki E, Mori T, Tsuruga K, Sohara E, Uchida S, Tanaka H. Complete clinical resolution of a Japanese family with renal pseudohypoaldosteronism type 1 due to a novel NR3C2 mutation. Nephrology (Carlton, Vic.). 2019.04; 24 (4): 489-490. ( PubMed, DOI )

  28. Sekine A, Fujimaru T, Hoshino J, Suwabe T, Oguro M, Mizuno H, Kawada M, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Mandai S, Chiga M, Kikuchi H, Ando F, Mori T, Sohara E, Uchida S, Sawa N, Takaichi K, Ubara Y. Genotype-Clinical Correlations in Polycystic Kidney Disease with No Apparent Family History. American journal of nephrology. 2019.02; 49 (3): 233-240. ( PubMed, DOI )

  29. Suzuki S, Naito S, Numasawa Y, Asada M, Shoji N, Zeniya M, Takahashi D, Sato H, Iimori S, Nomura N, Sohara E, Okado T, Ishiwata Y, Nagata M, Rai T, Yokota T, Uchida S. Encephalopathy Induced by High Plasma and Cerebrospinal Fluid Ceftriaxone Concentrations in a Hemodialysis Patient. Internal medicine (Tokyo, Japan). 2019.02; ( PubMed, DOI )

  30. Watanabe S, Ino J, Fujimaru T, Taneda S, Akihisa T, Makabe S, Kataoka H, Mori T, Sohara E, Uchida S, Nitta K, Mochizuki T. <i>PKD1</i> mutation may epistatically ameliorate nephronophthisis progression in patients with <i>NPHP1</i> deletion. Clinical case reports. 2019.02; 7 (2): 336-339. ( PubMed, DOI )

  31. Kikuchi H, Sasaki E, Nomura N, Mori T, Minamishima YA, Yoshizaki Y, Takahashi N, Furusho T, Arai Y, Mandai S, Yamashita T, Ando F, Maejima Y, Isobe K, Okado T, Rai T, Uchida S, Sohara E. Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease. Kidney international. 2019.01; 95 (1): 123-137. ( PubMed, DOI )

  32. Yoshida Sayaka, Araki Yuya, Mori Takayasu, Sasaki Emi, Kasagi Yuri, Isobe Kiyoshi, Susa Koichiro, Inoue Yuichi, Bomont Pascale, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi, Sohara Eisei. Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo Clinical and Experimental Nephrology. 2018.12; 22 (6): 1251-1257. ( ichushi )

  33. Matsumoto A, Matsui I, Mori T, Sakaguchi Y, Mizui M, Ueda Y, Takahashi A, Doi Y, Shimada K, Yamaguchi S, Kubota K, Hashimoto N, Oka T, Takabatake Y, Sohara E, Hamano T, Uchida S, Isaka Y. A Case of Severe Osteomalacia with Dent Disease Caused by a Novel Intronic Mutation of the CLCN5 gene. Internal medicine (Tokyo, Japan). 2018.08; ( PubMed, DOI )

  34. Yamauchi T, Doi S, Nakashima A, Doi T, Sohara E, Uchida S, Masaki T. Na-Cl cotransporter-mediated chloride uptake contributes to hypertension and renal damage in aldosterone-infused rats. American journal of physiology. Renal physiology. 2018.08; 315 (2): F300-F312. ( PubMed, DOI )

  35. Hashimoto H, Nomura N, Shoda W, Isobe K, Kikuchi H, Yamamoto K, Fujimaru T, Ando F, Mori T, Okado T, Rai T, Uchida S, Sohara E. Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium-chloride cotransporter. Metabolism: clinical and experimental. 2018.08; 85 23-31. ( PubMed, DOI )

  36. Fujimaru T., Mori T., Sekine A., Mandai S., Chiga M., Kikuchi H., Ando F., Mori Y., Nomura N., Iimori S., Naito S., Okado T., Rai T., Hoshino J., Ubara Y., Uchida S., Sohara E.. Kidney enlargement and multiple liver cyst formation implicate mutations in PKD1/2 in adult sporadic polycystic kidney disease CLINICAL GENETICS. 2018.07; 94 (1): 125-131. ( DOI )

  37. Yoshida S, Araki Y, Mori T, Sasaki E, Kasagi Y, Isobe K, Susa K, Inoue Y, Bomont P, Okado T, Rai T, Uchida S, Sohara E. Decreased KLHL3 expression is involved in the pathogenesis of pseudohypoaldosteronism type II caused by cullin 3 mutation in vivo. Clinical and experimental nephrology. 2018.06; ( PubMed, DOI )

  38. Miyamoto S, Ohkubo A, Seshima H, Yamamoto H, Itagaki A, Maeda T, Kurashima N, Mori T, Iimori S, Naito S, Sohara E, Rai T, Uchida S, Okado T. Removal Dynamics of Autoantibodies, Immunoglobulins, and Coagulation Factors by Selective Plasma Exchange on Three Consecutive Days. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2018.06; 22 (3): 255-260. ( PubMed, DOI )

  39. Miyamoto Satoko, Ohkubo Atsushi, Seshima Hiroshi, Yamamoto Hiroko, Itagaki Ayako, Maeda Takuma, Kurashima Naoki, Mori Takayasu, Iimori Soichiro, Naito Shotaro, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi, Okado Tomokazu. Removal Dynamics of Autoantibodies, Immunoglobulins, and Coagulation Factors by Selective Plasma Exchange on Three Consecutive Days(和訳中) Therapeutic Apheresis and Dialysis. 2018.06; 22 (3): 255-260. ( ichushi )

  40. Mandai S, Mori T, Nomura N, Furusho T, Arai Y, Kikuchi H, Sasaki E, Sohara E, Rai T, Uchida S. WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4. Scientific reports. 2018.06; 8 (1): 9101. ( PubMed, DOI )

  41. Toriu N, Mizuno H, Sawa N, Sumida K, Suwabe T, Hayami N, Sekine A, Yamanouchi M, Hoshino J, Takaichi K, Yanagita M, Fujimaru T, Mori T, Sohara E, Uchida S, Ubara Y. Everolimus Reduces the Size of Tuberous Sclerosis Complex-Related Huge Renal Angiomyolipomas Exceeding 20 cm in the Longest Diameter. Case reports in oncology. 2018.05; 11 (2): 258-267. ( PubMed, DOI )

  42. Ando F, Mori S, Yui N, Morimoto T, Nomura N, Sohara E, Rai T, Sasaki S, Kondo Y, Kagechika H, Uchida S. AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus. Nature communications. 2018.04; 9 (1): 1411. ( PubMed, DOI )

  43. Arai Yohei, Kanda Eiichiro, Iimori Soichiro, Naito Shotaro, Noda Yumi, Sasaki Sei, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi. Low white blood cell count is independently associated with chronic kidney disease progression in the elderly: the CKD-ROUTE study Clinical and Experimental Nephrology. 2018.04; 22 (2): 291-298. ( ichushi )

  44. Mandai S, Sato H, Iimori S, Naito S, Mori T, Takahashi D, Zeniya M, Nomura N, Sohara E, Okado T, Uchida S, Fushimi K, Rai T. Dialysis Case Volume Associated With In-Hospital Mortality in Maintenance Dialysis Patients. Kidney international reports. 2018.03; 3 (2): 356-363. ( PubMed, DOI )

  45. Takada D, Sekine A, Yabuuchi J, Kogure Y, Ueno T, Yamanouchi M, Sumida K, Suwabe T, Hayami N, Hoshino J, Takaichi K, Kinowaki K, Fujii T, Ohashi K, Mori T, Sohara E, Uchida S, Ubara Y. Renal histology and MRI in a 25-year-old Japanese man with nephronophthisis 4
. Clinical nephrology. 2018.03; 89 (3): 223-228. ( PubMed, DOI )

  46. Wang Yuanlong, Nomura Naohiro, Zeniya Moko, Mori Yutaro, Takahashi Daiei, Naito Shotaro, Rai Tatemitsu, Uchida Shinichi, Sohara Eisei. マウス血管平滑筋細胞において、高濃度カリウムはkelch様蛋白質2を介してWNK3-SPAK-NKCC1のリン酸化カスケードを制御する(High potassium concentration regulates the WNK3-SPAK-NKCC1 phosphorylation cascade via kelch-like protein 2 in mouse vascular smooth muscle cells) Journal of Medical and Dental Sciences. 2018.03; 65 (1): 35-44. ( ichushi )

  47. Saran Saran Adya, Hosoi Yasushi, Sohara Eisei, Mutoh Hiroki, Akita Tenpei, Uchida Shinichi, Fukuda Atsuo. WNK3 kinaseはマウス前頭前皮質のV層錐体神経細胞における内向き整流性potassium電流を制御する(WNK3 kinase regulates inwardly rectifying potassium current in layer V pyramidal neurons of the mouse prefrontal cortex) The Journal of Physiological Sciences. 2018.03; 68 (Suppl.1): S168. ( ichushi )

  48. Nomura N, Shoda W, Wang Y, Mandai S, Furusho T, Takahashi D, Zeniya M, Sohara E, Rai T, Uchida S. Role of ClC-K and barttin in low potassium-induced sodium chloride cotransporter activation and hypertension in mouse kidney. Bioscience reports. 2018.02; 38 (1): ( PubMed, DOI )

  49. Toriu N, Hoshino J, Kobori S, Watanabe S, Oguro M, Oshima Y, Hiramatsu R, Mizuno H, Ikuma D, Sekine A, Hayami N, Sumida K, Yamanouchi M, Hasegawa E, Sawa N, Takaichi K, Yanagita M, Fujimaru T, Sohara E, Uchida S, Ubara Y. Transcatheter Arterial Embolization Therapy for Huge Renal Cysts: Two Case Reports. Case reports in nephrology and dialysis. 2018.01; 8 (1): 82-89. ( PubMed, DOI )

  50. Ishikawa S, Naito S, Iimori S, Takahashi D, Zeniya M, Sato H, Nomura N, Sohara E, Okado T, Uchida S, Rai T. Loop diuretics are associated with greater risk of sarcopenia in patients with non-dialysis-dependent chronic kidney disease. PloS one. 2018; 13 (2): e0192990. ( PubMed, DOI )

  51. Iimori S, Naito S, Noda Y, Sato H, Nomura N, Sohara E, Okado T, Sasaki S, Uchida S, Rai T. Prognosis of chronic kidney disease with normal-range proteinuria: The CKD-ROUTE study. PloS one. 2018; 13 (1): e0190493. ( PubMed, DOI )

  52. Kikuchi H, Kanda E, Mori T, Sato H, Iimori S, Nomura N, Naito S, Sohara E, Okado T, Uchida S, Fushimi K, Rai T. Short-term prognosis of emergently hospitalized dialysis-independent chronic kidney disease patients: A nationwide retrospective cohort study in Japan. PloS one. 2018; 13 (11): e0208258. ( PubMed, DOI )

  53. Ito Y, Sekine A, Takada D, Yabuuchi J, Kogure Y, Ueno T, Sumida K, Yamanouchi M, Hayami N, Suwabe T, Hoshino J, Sawa N, Takaichi K, Kinowaki K, Fujii T, Ohashi K, Kikuchi H, Mandai S, Chiga M, Mori T, Sohara E, Uchida S, Ubara Y. Renal histology and MRI findings in a 37-year-old Japanese patient with autosomal recessive polycystic kidney disease
. Clinical nephrology. 2017.11; 88 (11): 292-297. ( PubMed, DOI )

  54. Mishima Eikan, Mori Takayasu, Sohara Eisei, Uchida Shinichi, Abe Takaaki, Ito Sadayoshi. シェーグレン症候群患者における後天性でなく遺伝性のGitelman症候群 遺伝形質の鑑別における遺伝子変異解析の重要性(Inherited, not acquired, Gitelman syndrome in a patient with Sjoegren's syndrome: importance of genetic testing to distinguish the two forms) CEN Case Reports. 2017.11; 6 (2): 180-184. ( ichushi )

  55. Mishima E, Mori T, Sohara E, Uchida S, Abe T, Ito S. Inherited, not acquired, Gitelman syndrome in a patient with Sjögren's syndrome: importance of genetic testing to distinguish the two forms. CEN case reports. 2017.11; 6 (2): 180-184. ( PubMed, DOI )

  56. Zeniya M, Mori T, Yui N, Nomura N, Mandai S, Isobe K, Chiga M, Sohara E, Rai T, Uchida S. The proteasome inhibitor bortezomib attenuates renal fibrosis in mice via the suppression of TGF-β1. Scientific reports. 2017.10; 7 (1): 13086. ( PubMed, DOI )

  57. Arai Yohei, Kanda Eiichiro, Iimori Soichiro, Naito Shotaro, Noda Yumi, Sasaki Sei, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi. Low white blood cell count is independently associated with chronic kidney disease progression in the elderly: the CKD-ROUTE study. Clin Exp Nephrol. 2017.07; ( PubMed, DOI )

  58. Susa Koichiro, Sohara Eisei, Takahashi Daiei, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi. WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3. Biochem Biophys Res Commun. 2017.07; ( PubMed, DOI )

  59. Arai Yohei, Kanda Eiichiro, Iimori Soichiro, Naito Shotaro, Noda Yumi, Kawasaki Tomoki, Sato Hidehiko, Ando Ryoichi, Sasaki Sei, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi. The use of vitamin D analogs is independently associated with the favorable renal prognosis in chronic kidney disease stages 4-5: the CKD-ROUTE study. Clin Exp Nephrol. 2017.06; 21 (3): 481-487. ( PubMed, DOI )

  60. Ohkubo Atsushi, Okado Tomokazu, Miyamoto Satoko, Hashimoto Yurie, Komori Shigeto, Yamamoto Motoki, Maeda Takuma, Itagaki Ayako, Yamamoto Hiroko, Seshima Hiroshi, Kurashima Naoki, Iimori Soichiro, Naito Shotaro, Sohara Eisei, Uchida Shinichi, Rai Tatemitsu. Fibrinogen Reduction During Selective Plasma Exchange due to Membrane Fouling. Ther Apher Dial. 2017.06; 21 (3): 232-237. ( PubMed, DOI )

  61. Miyamoto Satoko, Ohkubo Atsushi, Seshima Hiroshi, Komori Shigeto, Yamamoto Motoki, Maeda Takuma, Itagaki Ayako, Yamamoto Hiroko, Nojima Kohei, Iimori Soichiro, Naito Shotaro, Kurashima Naoki, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi, Okado Tomokazu. Selective Plasma Exchange for the Removal of Pemphigus Autoantibodies, Fibrinogen, and Factor XIII in Pemphigus Vulgaris. Ther Apher Dial. 2017.06; 21 (3): 226-231. ( PubMed, DOI )

  62. Yoshizaki Yuki, Mori Takayasu, Ishigami-Yuasa Mari, Kikuchi Eriko, Takahashi Daiei, Zeniya Moko, Nomura Naohiro, Mori Yutaro, Araki Yuya, Ando Fumiaki, Mandai Shintaro, Kasagi Yuri, Arai Yohei, Sasaki Emi, Yoshida Sayaka, Kagechika Hiroyuki, Rai Tatemitsu, Uchida Shinichi, Sohara Eisei. Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy. Sci Rep. 2017.06; 7 (1): 3945. ( PubMed, DOI )

  63. Arai Yohei, Kanda Eiichiro, Iimori Soichiro, Naito Shotaro, Noda Yumi, Kawasaki Tomoki, Sato Hidehiko, Ando Ryoichi, Sasaki Sei, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi. ステージ4・5慢性腎臓病に対するビタミンD類似体の使用は好ましい腎予後と独立して関連する CKD-ROUTE研究(The use of vitamin D analogs is independently associated with the favorable renal prognosis in chronic kidney disease stages 4-5: the CKD-ROUTE study) Clinical and Experimental Nephrology. 2017.06; 21 (3): 481-487. ( ichushi )

  64. Ohkubo Atsushi, Okado Tomokazu, Miyamoto Satoko, Hashimoto Yurie, Komori Shigeto, Yamamoto Motoki, Maeda Takuma, Itagaki Ayako, Yamamoto Hiroko, Seshima Hiroshi, Kurashima Naoki, Iimori Soichiro, Naito Shotaro, Sohara Eisei, Uchida Shinichi, Rai Tatemitsu. 選択的血漿交換におけるフィブリノゲンの減少は膜ファウリングに起因する(Fibrinogen Reduction During Selective Plasma Exchange due to Membrane Fouling) Therapeutic Apheresis and Dialysis. 2017.06; 21 (3): 232-237. ( ichushi )

  65. Miyamoto Satoko, Ohkubo Atsushi, Seshima Hiroshi, Komori Shigeto, Yamamoto Motoki, Maeda Takuma, Itagaki Ayako, Yamamoto Hiroko, Nojima Kohei, Iimori Soichiro, Naito Shotaro, Kurashima Naoki, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi, Okado Tomokazu. 尋常性天疱瘡における選択的血漿交換法による抗デスモグレイン自己抗体、フィブリノゲン、凝固第XIII因子の除去(Selective Plasma Exchange for the Removal of Pemphigus Autoantibodies, Fibrinogen, and Factor XIII in Pemphigus Vulgaris) Therapeutic Apheresis and Dialysis. 2017.06; 21 (3): 226-231. ( ichushi )

  66. Kasagi Yuri, Takahashi Daiei, Aida Tomomi, Nishida Hidenori, Nomura Naohiro, Zeniya Moko, Mori Takayasu, Sasaki Emi, Ando Fumiaki, Rai Tatemitsu, Uchida Shinichi, Sohara Eisei. Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice. Biochem Biophys Res Commun. 2017.05; 487 (2): 368-374. ( PubMed, DOI )

  67. Ito Sakuya, Taguchi Kensei, Nakayama Yosuke, Kaida Yusuke, Sohara Eisei, Uchida Shinichi, Fukami Kei. INCREASED SODIUM CHLORIDE COTRANSPORTER EXPRESSION IN A RAT REMNANT KIDNEY MODEL NEPHROLOGY DIALYSIS TRANSPLANTATION. 2017.05; 32

  68. Takahashi Daiei, Mori Takayasu, Sohara Eisei, Tanaka Miyako, Chiga Motoko, Inoue Yuichi, Nomura Naohiro, Zeniya Moko, Ochi Hiroki, Takeda Shu, Suganami Takayoshi, Rai Tatemitsu, Uchida Shinichi. WNK4 is an Adipogenic Factor and Its Deletion Reduces Diet-Induced Obesity in Mice. EBioMedicine. 2017.04; 18 118-127. ( PubMed, DOI )

  69. Arai Yohei, Takahashi Daiei, Asano Kenichi, Tanaka Masato, Oda Mayumi, Ko Shigeru B H, Ko Minoru S H, Mandai Shintaro, Nomura Naohiro, Rai Tatemitsu, Uchida Shinichi, Sohara Eisei. Salt suppresses IFNgamma inducible chemokines through the IFNgamma-JAK1-STAT1 signaling pathway in proximal tubular cells. Sci Rep. 2017.04; 7 46580. ( PubMed, DOI )

  70. Mandai Shintaro, Furukawa Susumu, Kodaka Manami, Hata Yutaka, Mori Takayasu, Nomura Naohiro, Ando Fumiaki, Mori Yutaro, Takahashi Daiei, Yoshizaki Yuki, Kasagi Yuri, Arai Yohei, Sasaki Emi, Yoshida Sayaka, Furuichi Yasuro, Fujii Nobuharu L, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi. Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy. Sci Rep. 2017.04; 7 46369. ( PubMed, DOI )

  71. Sasaki Emi, Susa Koichiro, Mori Takayasu, Isobe Kiyoshi, Araki Yuya, Inoue Yuichi, Yoshizaki Yuki, Ando Fumiaki, Mori Yutaro, Mandai Shintaro, Zeniya Moko, Takahashi Daiei, Nomura Naohiro, Rai Tatemitsu, Uchida Shinichi, Sohara Eisei. KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3. Mol Cell Biol. 2017.03; 37 (7): ( PubMed, DOI )

  72. Sinha Adya Saran, Hosoi Yasushi, Sohara Eisei, Mutoh Hiroki, Akita Tenpei, Uchida Shinichi, Fukuda Atsuo. 前頭前野の第V層錐体神経細胞におけるWNK3の興奮に関する役割(Excitatory roles of WNK3 in layer V pyramidal neurons in the prefrontal cortex) The Journal of Physiological Sciences. 2017.03; 67 (Suppl.1): S116. ( ichushi )

  73. Mori Takayasu, Hosomichi Kazuyoshi, Chiga Motoko, Mandai Shintaro, Nakaoka Hirofumi, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Sasaki Sei, Inoue Ituro, Uchida Shinichi. Comprehensive genetic testing approach for major inherited kidney diseases, using next-generation sequencing with a custom panel. Clin Exp Nephrol. 2017.02; 21 (1): 63-75. ( PubMed, DOI )

  74. Kikuchi Hiroaki, Kanda Eiichiro, Mandai Shintaro, Akazawa Masanobu, Iimori Soichiro, Oi Katsuyuki, Naito Shotaro, Noda Yumi, Toda Takayuki, Tamura Teiichi, Sasaki Sei, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi. Combination of low body mass index and serum albumin level is associated with chronic kidney disease progression: the chronic kidney disease-research of outcomes in treatment and epidemiology (CKD-ROUTE) study. Clin Exp Nephrol. 2017.02; 21 (1): 55-62. ( PubMed, DOI )

  75. Mandai Shintaro, Kanda Eiichiro, Iimori Soichiro, Naito Shotaro, Noda Yumi, Kikuchi Hiroaki, Akazawa Masanobu, Oi Katsuyuki, Toda Takayuki, Sohara Eisei, Okado Tomokazu, Sasaki Sei, Rai Tatemitsu, Uchida Shinichi. Association of serum chloride level with mortality and cardiovascular events in chronic kidney disease: the CKD-ROUTE study. Clin Exp Nephrol. 2017.02; 21 (1): 104-111. ( PubMed, DOI )

  76. Shoda Wakana, Nomura Naohiro, Ando Fumiaki, Mori Yutaro, Mori Takayasu, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi. Calcineurin inhibitors block sodium-chloride cotransporter dephosphorylation in response to high potassium intake. Kidney Int. 2017.02; 91 (2): 402-411. ( PubMed, DOI )

  77. Mori Takayasu, Hosomichi Kazuyoshi, Chiga Motoko, Mandai Shintaro, Nakaoka Hirofumi, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Sasaki Sei, Inoue Ituro, Uchida Shinichi. カスタムパネルによる次世代シーケンシングを用いた主要な遺伝性腎疾患に対する包括的遺伝子検査手法(Comprehensive genetic testing approach for major inherited kidney diseases, using next-generation sequencing with a custom panel) Clinical and Experimental Nephrology. 2017.02; 21 (1): 63-75. ( ichushi )

  78. Mandai Shintaro, Kanda Eiichiro, Iimori Soichiro, Naito Shotaro, Noda Yumi, Kikuchi Hiroaki, Akazawa Masanobu, Oi Katsuyuki, Toda Takayuki, Sohara Eisei, Okado Tomokazu, Sasaki Sei, Rai Tatemitsu, Uchida Shinichi. 慢性腎疾患における血清塩化物濃度と死亡率および心血管イベントとの関連 CKD-ROUTE研究(Association of serum chloride level with mortality and cardiovascular events in chronic kidney disease: the CKD-ROUTE study) Clinical and Experimental Nephrology. 2017.02; 21 (1): 104-111. ( ichushi )

  79. Kikuchi Hiroaki, Kanda Eiichiro, Mandai Shintaro, Akazawa Masanobu, Iimori Soichiro, Oi Katsuyuki, Naito Shotaro, Noda Yumi, Toda Takayuki, Tamura Teiichi, Sasaki Sei, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi. 低いBMIと血清アルブミン値の組み合わせは慢性腎疾患進行と関連する chronic kidney-research of outcomes in treatment and epidemiology(CKD-ROUTE)研究(Combination of low body mass index and serum albumin level is associated with chronic kidney disease progression: the chronic kidney disease-research of outcomes in treatment and epidemiology(CKD-ROUTE) study) Clinical and Experimental Nephrology. 2017.02; 21 (1): 55-62. ( ichushi )

  80. Kusuda Takeshi, Hosoya Tadashi, Mori Takayasu, Ihara Katsuhito, Nishida Hidenori, Chiga Motoko, Sohara Eisei, Rai Tatemitsu, Koike Ryuji, Uchida Shinichi, Kohsaka Hitoshi. Acquired Gitelman Syndrome in an Anti-SSA Antibody-positive Patient with a SLC12A3 Heterozygous Mutation. Intern Med. 2016.11; 55 (21): 3201-3204. ( PubMed, DOI )

  81. Ando Fumiaki, Sohara Eisei, Morimoto Tetsuji, Yui Naofumi, Nomura Naohiro, Kikuchi Eriko, Takahashi Daiei, Mori Takayasu, Vandewalle Alain, Rai Tatemitsu, Sasaki Sei, Kondo Yoshiaki, Uchida Shinichi. Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway. Nat Commun. 2016.11; 7 13636. ( PubMed, DOI )

  82. Sohara Eisei, Uchida Shinichi. Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder. Nephrol Dial Transplant. 2016.09; 31 (9): 1417-1424. ( PubMed, DOI )

  83. Ohkubo Atsushi, Okado Tomokazu, Miyamoto Satoko, Goto Keigo, Yamamoto Motoki, Maeda Takuma, Itagaki Ayako, Seshima Hiroshi, Kurashima Naoki, Sohara Eisei, Uchida Shinichi, Rai Tatemitsu. Removal Characteristics of Immunoadsorption With the Immusorba TR-350 Column Using Conventional and Selective Plasma Separators. Ther Apher Dial. 2016.08; 20 (4): 360-367. ( PubMed, DOI )

  84. Miyamoto Satoko, Ohkubo Atsushi, Seshima Hiroshi, Maeda Takuma, Itagaki Ayako, Kurashima Naoki, Iimori Soichiro, Naito Shotaro, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi, Okado Tomokazu. Removal Dynamics of Immunoglobulin and Fibrinogen by Conventional Plasma Exchange, Selective Plasma Exchange, and a Combination of the Two. Ther Apher Dial. 2016.08; 20 (4): 342-347. ( PubMed, DOI )

  85. Rahman Asadur, Kittikulsuth Wararat, Fujisawa Yoshihide, Sufiun Abu, Rafiq Kazi, Hitomi Hirofumi, Nakano Daisuke, Sohara Eisei, Uchida Shinichi, Nishiyama Akira. Effects of diuretics on sodium-dependent glucose cotransporter 2 inhibitor-induced changes in blood pressure in obese rats suffering from the metabolic syndrome. J Hypertens. 2016.05; 34 (5): 893-906. ( PubMed, DOI )

  86. Mandai Shintaro, Mori Takayasu, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi. Generation of Hypertension-Associated STK39 Polymorphism Knockin Cell Lines With the Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 System. Hypertension. 2015.12; 66 (6): 1199-1206. ( PubMed, DOI )

  87. Mori Yutaro, Mori Takayasu, Wakabayashi Mai, Yoshizaki Yuki, Zeniya Moko, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi. Involvement of selective autophagy mediated by p62/SQSTM1 in KLHL3-dependent WNK4 degradation. Biochem J. 2015.11; 472 (1): 33-41. ( PubMed, DOI )

  88. Yoshizaki Yuki, Mori Yutaro, Tsuzaki Yoshihito, Mori Takayasu, Nomura Naohiro, Wakabayashi Mai, Takahashi Daiei, Zeniya Moko, Kikuchi Eriko, Araki Yuya, Ando Fumiaki, Isobe Kiyoshi, Nishida Hidenori, Ohta Akihito, Susa Koichiro, Inoue Yuichi, Chiga Motoko, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi, Sohara Eisei. Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3. Biochem Biophys Res Commun. 2015.11; 467 (2): 229-234. ( PubMed, DOI )

  89. Araki Yuya, Rai Tatemitsu, Sohara Eisei, Mori Takayasu, Inoue Yuichi, Isobe Kiyoshi, Kikuchi Eriko, Ohta Akihito, Sasaki Sei, Uchida Shinichi. Generation and analysis of knock-in mice carrying pseudohypoaldosteronism type II-causing mutations in the cullin 3 gene. Biol Open. 2015.10; 4 (11): 1509-1517. ( PubMed, DOI )

  90. Zeniya Moko, Morimoto Nobuhisa, Takahashi Daiei, Mori Yutaro, Mori Takayasu, Ando Fumiaki, Araki Yuya, Yoshizaki Yuki, Inoue Yuichi, Isobe Kiyoshi, Nomura Naohiro, Oi Katsuyuki, Nishida Hidenori, Sasaki Sei, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi. Kelch-Like Protein 2 Mediates Angiotensin II-With No Lysine 3 Signaling in the Regulation of Vascular Tonus. J Am Soc Nephrol. 2015.09; 26 (9): 2129-2138. ( PubMed, DOI )

  91. Ohkubo Atsushi, Okado Tomokazu, Kurashima Naoki, Maeda Takuma, Arai Shingo, Miyamoto Satoko, Itagaki Ayako, Seshima Hiroshi, Iimori Soichiro, Naito Shotaro, Sohara Eisei, Uchida Shinichi, Rai Tatemitsu. Removal Characteristics of Immunoglobulin G Subclasses by Conventional Plasma Exchange and Selective Plasma Exchange. Ther Apher Dial. 2015.08; 19 (4): 361-366. ( PubMed, DOI )

  92. Kikuchi Eriko, Mori Takayasu, Zeniya Moko, Isobe Kiyoshi, Ishigami-Yuasa Mari, Fujii Shinya, Kagechika Hiroyuki, Ishihara Tomoaki, Mizushima Tohru, Sasaki Sei, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi. Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters. J Am Soc Nephrol. 2015.07; 26 (7): 1525-1536. ( PubMed, DOI )

  93. Oi Katsuyuki, Okado Tomokazu, Togo Hisako, Iimori Soichiro, Yui Naofumi, Sohara Eisei, Kanda Eiichiro, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. Two Cases of Hemodialysis-associated Chronic Portal-systemic Shunt Encephalopathy (CPSE) with Opposite Changes in the Blood Ammonia Concentrations during Hemodialysis: A Case Report and Literature Review. Intern Med. 2015.06; 54 (11): 1375-1380. ( PubMed, DOI )

  94. Miyauchi Takayuki, Yamamoto Hiroyuki, Abe Yoichiro, Yoshida Go J, Rojek Aleksandra, Sohara Eisei, Uchida Shinichi, Nielsen Soren, Yasui Masato. Dynamic subcellular localization of aquaporin-7 in white adipocytes. FEBS Lett. 2015.02; 589 (5): 608-614. ( PubMed, DOI )

  95. Inoue Yuichi, Sohara Eisei, Kobayashi Katsuki, Chiga Motoko, Rai Tatemitsu, Ishibashi Kenichi, Horie Shigeo, Su Xuefeng, Zhou Jing, Sasaki Sei, Uchida Shinichi. Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in an AQP11 knockout model. J Am Soc Nephrol. 2014.12; 25 (12): 2789-2799. ( PubMed, DOI )

  96. Susa Koichiro, Sohara Eisei, Rai Tatemitsu, Zeniya Moko, Mori Yutaro, Mori Takayasu, Chiga Motoko, Nomura Naohiro, Nishida Hidenori, Takahashi Daiei, Isobe Kiyoshi, Inoue Yuichi, Takeishi Kenta, Takeda Naoki, Sasaki Sei, Uchida Shinichi. Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice. Hum Mol Genet. 2014.10; 23 (19): 5052-5060. ( PubMed, DOI )

  97. Ohkubo Atsushi, Okado Tomokazu, Kurashima Naoki, Maeda Takuma, Miyamoto Satoko, Nakamura Ayako, Seshima Hiroshi, Iimori Soichiro, Sohara Eisei, Uchida Shinichi, Rai Tatemitsu. Removal kinetics of antibodies against glutamic acid decarboxylase by various plasmapheresis modalities in the treatment of neurological disorders. Ther Apher Dial. 2014.06; 18 (3): 231-237. ( PubMed, DOI )

  98. Takahashi Daiei, Mori Takayasu, Nomura Naohiro, Khan Muhammad Zakir Hossain, Araki Yuya, Zeniya Moko, Sohara Eisei, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. WNK4 is the major WNK positively regulating NCC in the mouse kidney. Biosci Rep. 2014.05; 34 (3): ( PubMed, DOI )

  99. Uchida Shinichi, Sohara Eisei, Rai Tatemitsu, Sasaki Sei. Regulation of with-no-lysine kinase signaling by Kelch-like proteins. Biol Cell. 2014.02; 106 (2): 45-56. ( PubMed, DOI )

  100. Mori Takayasu, Kikuchi Eriko, Watanabe Yuko, Fujii Shinya, Ishigami-Yuasa Mari, Kagechika Hiroyuki, Sohara Eisei, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy. Biochem J. 2013.11; 455 (3): 339-345. ( PubMed, DOI )

  101. Isobe Kiyoshi, Mori Takayasu, Asano Takako, Kawaguchi Hiroyuki, Nonoyama Shigeaki, Kumagai Naonori, Kamada Fumiaki, Morimoto Tetsuji, Hayashi Matsuhiko, Sohara Eisei, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. Development of enzyme-linked immunosorbent assays for urinary thiazide-sensitive Na-Cl cotransporter measurement. Am J Physiol Renal Physiol. 2013.11; 305 (9): F1374-F1381. ( PubMed, DOI )

  102. Nomura Naohiro, Kamiya Kazusaku, Ikeda Katsuhisa, Yui Naofumi, Chiga Motoko, Sohara Eisei, Rai Tatemitu, Sakaki Sei, Uchida Shinich. Treatment with 17-allylamino-17-demethoxygeldanamycin ameliorated symptoms of Bartter syndrome type IV caused by mutated Bsnd in mice. Biochem Biophys Res Commun. 2013.11; 441 (3): 544-549. ( PubMed, DOI )

  103. Zeniya Moko, Sohara Eisei, Kita Satomi, Iwamoto Takahiro, Susa Koichiro, Mori Takayasu, Oi Katsuyuki, Chiga Motoko, Takahashi Daiei, Yang Sung-Sen, Lin Shih-Hua, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II. Hypertension. 2013.11; 62 (5): 872-878. ( PubMed, DOI )

  104. Ando Fumiaki, Okado Tomokazu, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi, Sasaki Sei. Development of minimal-change glomerular disease and Hashimoto's thyroiditis during the treatment of sarcoidosis. CEN Case Rep. 2013.11; 2 (2): 248-251. ( PubMed, DOI )

  105. Ishimoto Ikue, Sohara Eisei, Ito Eisaku, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi. Fibronectin glomerulopathy. Clin Kidney J. 2013.10; 6 (5): 513-515. ( PubMed, DOI )

  106. Mori Yutaro, Wakabayashi Mai, Mori Takayasu, Araki Yuya, Sohara Eisei, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms. Biochem Biophys Res Commun. 2013.09; 439 (1): 30-34. ( PubMed, DOI )

  107. Takahashi Daiei, Mori Takayasu, Wakabayashi Mai, Mori Yutaro, Susa Koichiro, Zeniya Moko, Sohara Eisei, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. KLHL2 interacts with and ubiquitinates WNK kinases. Biochem Biophys Res Commun. 2013.08; 437 (3): 457-462. ( PubMed, DOI )

  108. Ando Fumiaki, Sohara Eisei, Ito Eisaku, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi, Sasaki Sei. Acute poststreptococcal glomerulonephritis with acute interstitial nephritis related to streptococcal pyrogenic exotoxin B. Clin Kidney J. 2013.06; 6 (3): 347-348. ( PubMed, DOI )

  109. Inoue Risako, Sohara Eisei, Rai Tatemitsu, Satoh Takahiro, Yokozeki Hiroo, Sasaki Sei, Uchida Shinichi. Immunolocalization and translocation of aquaporin-5 water channel in sweat glands. J Dermatol Sci. 2013.04; 70 (1): 26-33. ( PubMed, DOI )

  110. Wakabayashi Mai, Mori Takayasu, Isobe Kiyoshi, Sohara Eisei, Susa Koichiro, Araki Yuya, Chiga Motoko, Kikuchi Eriko, Nomura Naohiro, Mori Yutaro, Matsuo Hiroshi, Murata Tomohiro, Nomura Shinsuke, Asano Takako, Kawaguchi Hiroyuki, Nonoyama Shigeaki, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. Cell Rep. 2013.03; 3 (3): 858-868. ( PubMed, DOI )

  111. Susa Koichiro, Sohara Eisei, Isobe Kiyoshi, Chiga Motoko, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. WNK-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone. Biochem Biophys Res Commun. 2012.11; 427 (4): 743-747. ( PubMed, DOI )

  112. Nishida Hidenori, Sohara Eisei, Nomura Naohiro, Chiga Motoko, Alessi Dario R, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice. Hypertension. 2012.10; 60 (4): 981-990. ( PubMed, DOI )

  113. Uchida Shinichi, Chiga Motoko, Sohara Eisei, Rai Tatemitsu, Sasaki Sei. Does a beta2-adrenergic receptor-WNK4-Na-Cl co-transporter signal cascade exist in the in vivo kidney? Nat Med. 2012.09; 18 (9): 1324-5; author reply 1325. ( PubMed, DOI )

  114. Susa Koichiro, Kita Satomi, Iwamoto Takahiro, Yang Sung-Sen, Lin Shih-Hua, Ohta Akihito, Sohara Eisei, Rai Tatemitsu, Sasaki Sei, Alessi Dario R, Uchida Shinichi. Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels. Clin Exp Nephrol. 2012.08; 16 (4): 530-538. ( PubMed, DOI )

  115. Hossain Khan Muhammad Zakir, Sohara Eisei, Ohta Akihito, Chiga Motoko, Inoue Yuichi, Isobe Kiyoshi, Wakabayashi Mai, Oi Katsuyuki, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination. Biochem Biophys Res Commun. 2012.08; 425 (2): 456-461. ( PubMed, DOI )

  116. Ohta Eriko, Akazawa Masanobu, Noda Yumi, Mandai Shintaro, Naito Shotaro, Ohta Akihito, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Uchida Shinichi, Sasaki Sei. Severe hyperparathyroidism in a pre-dialysis chronic kidney disease patient treated with a very low protein diet. J Bone Miner Metab. 2012.03; 30 (2): 238-242. ( PubMed, DOI )

  117. Oi Katsuyuki, Sohara Eisei, Rai Tatemitsu, Misawa Moko, Chiga Motoko, Alessi Dario R, Sasaki Sei, Uchida Shinichi. A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo. Biol Open. 2012.02; 1 (2): 120-127. ( PubMed, DOI )

  118. Hara-Chikuma Mariko, Sugiyama Yoshinori, Kabashima Kenji, Sohara Eisei, Uchida Shinichi, Sasaki Sei, Inoue Shintaro, Miyachi Yoshiki. Involvement of aquaporin-7 in the cutaneous primary immune response through modulation of antigen uptake and migration in dendritic cells. FASEB J. 2012.01; 26 (1): 211-218. ( PubMed, DOI )

  119. Lin Shih-Hua, Yu I-Shing, Jiang Si-Tse, Lin Shu-Wha, Chu Pauling, Chen Ann, Sytwu Huey-Kang, Sohara Eisei, Uchida Shinichi, Sasaki Sei, Yang Sung-Sen. Impaired phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci U S A. 2011.10; 108 (42): 17538-17543. ( PubMed, DOI )

  120. Nomura Naohiro, Tajima Masato, Sugawara Noriko, Morimoto Tetsuji, Kondo Yoshiaki, Ohno Mayuko, Uchida Keiko, Mutig Kerim, Bachmann Sebastian, Soleimani Manoocher, Ohta Eriko, Ohta Akihito, Sohara Eisei, Okado Tomokazu, Rai Tatemitsu, Jentsch Thomas J, Sasaki Sei, Uchida Shinichi. Generation and analyses of R8L barttin knockin mouse. Am J Physiol Renal Physiol. 2011.08; 301 (2): F297-F307. ( PubMed, DOI )

  121. Sohara Eisei, Rai Tatemitsu, Yang Sung-Sen, Ohta Akihito, Naito Shotaro, Chiga Motoko, Nomura Naohiro, Lin Shih-Hua, Vandewalle Alain, Ohta Eriko, Sasaki Sei, Uchida Shinichi. Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney. PLoS One. 2011.08; 6 (8): e24277. ( PubMed, DOI )

  122. Chiga Motoko, Rafiqi Fatema H, Alessi Dario R, Sohara Eisei, Ohta Akihito, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade. J Cell Sci. 2011.05; 124 (Pt 9): 1391-1395. ( PubMed, DOI )

  123. Naito Shotaro, Ohta Akihito, Sohara Eisei, Ohta Eriko, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. Regulation of WNK1 kinase by extracellular potassium. Clin Exp Nephrol. 2011.04; 15 (2): 195-202. ( PubMed, DOI )

  124. Noda Yumi, Sohara Eisei, Ohta Eriko, Sasaki Sei. Aquaporins in kidney pathophysiology. Nat Rev Nephrol. 2010.03; 6 (3): 168-178. ( PubMed, DOI )

  125. Talati Gulibaha, Ohta Akihito, Rai Tatemitsu, Sohara Eisei, Naito Shotaro, Vandewalle Alain, Sasaki Sei, Uchida Shinichi. Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney. Biochem Biophys Res Commun. 2010.03; 393 (4): 844-848. ( PubMed, DOI )

  126. Ohta Eriko, Itoh Tomohiro, Nemoto Tomomi, Kumagai Jiro, Ko Shigeru B H, Ishibashi Kenichi, Ohno Mayuko, Uchida Keiko, Ohta Akihito, Sohara Eisei, Uchida Shinichi, Sasaki Sei, Rai Tatemitsu. Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis. Am J Physiol Cell Physiol. 2009.12; 297 (6): C1368-C1378. ( PubMed, DOI )

  127. Yui Naofumi, Okutsu Rie, Sohara Eisei, Rai Tatemitsu, Ohta Akihito, Noda Yumi, Sasaki Sei, Uchida Shinichi. FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells. Am J Physiol Cell Physiol. 2009.12; 297 (6): C1389-C1396. ( PubMed, DOI )

  128. Ohta Akihito, Rai Tatemitsu, Yui Naofumi, Chiga Motoko, Yang Sung-Sen, Lin Shih-Hua, Sohara Eisei, Sasaki Sei, Uchida Shinichi. Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet. 2009.10; 18 (20): 3978-3986. ( PubMed, DOI )

  129. Sohara Eisei, Uchida Shinichi, Sasaki Sei. Function of aquaporin-7 in the kidney and the male reproductive system. Handb Exp Pharmacol. 2009.01; (190): 219-231. ( PubMed, DOI )

  130. Sohara Eisei, Luo Ying, Zhang Jingjing, Manning Danielle K, Beier David R, Zhou Jing. Nek8 regulates the expression and localization of polycystin-1 and polycystin-2. J Am Soc Nephrol. 2008.03; 19 (3): 469-476. ( PubMed, DOI )

  131. Yang Sung-Sen, Morimoto Tetsuji, Rai Tatemitsu, Chiga Motoko, Sohara Eisei, Ohno Mayuko, Uchida Keiko, Lin Shih-Hua, Moriguchi Tetsuo, Shibuya Hiroshi, Kondo Yoshiaki, Sasaki Sei, Uchida Shinichi. Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab. 2007.05; 5 (5): 331-344. ( PubMed, DOI )

  132. Sohara Eisei, Ueda Otoya, Tachibe Takanori, Hani Toshio, Jishage Kou-ichi, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. Morphologic and functional analysis of sperm and testes in Aquaporin 7 knockout mice. Fertil Steril. 2007.03; 87 (3): 671-676. ( PubMed, DOI )

  133. Yakata Kaya, Hiroaki Yoko, Ishibashi Kenichi, Sohara Eisei, Sasaki Sei, Mitsuoka Kaoru, Fujiyoshi Yoshinori. Aquaporin-11 containing a divergent NPA motif has normal water channel activity. Biochim Biophys Acta. 2007.03; 1768 (3): 688-693. ( PubMed, DOI )

  134. Sohara Eisei, Rai Tatemitsu, Yang Sung-Sen, Uchida Keiko, Nitta Kosaku, Horita Shigeru, Ohno Mayuko, Harada Akihiro, Sasaki Sei, Uchida Shinichi. Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation. Proc Natl Acad Sci U S A. 2006.09; 103 (38): 14217-14222. ( PubMed, DOI )

  135. Sohara Eisei, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. Physiological roles of AQP7 in the kidney: Lessons from AQP7 knockout mice. Biochim Biophys Acta. 2006.08; 1758 (8): 1106-1110. ( PubMed, DOI )

  136. Suda Shin, Rai Tatemitsu, Sohara Eisei, Sasaki Sei, Uchida Shinichi. Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter. Biochem Biophys Res Commun. 2006.05; 344 (1): 246-252. ( PubMed, DOI )

  137. Suzuki Tatsunori, Rai Tatemitsu, Hayama Atsushi, Sohara Eisei, Suda Shin, Itoh Tomohiro, Sasaki Sei, Uchida Shinichi. Intracellular localization of ClC chloride channels and their ability to form hetero-oligomers. J Cell Physiol. 2006.03; 206 (3): 792-798. ( PubMed, DOI )

  138. Sohara Eisei, Rai Tatemitsu, Miyazaki Jun-ichi, Verkman A S, Sasaki Sei, Uchida Shinichi. Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am J Physiol Renal Physiol. 2005.12; 289 (6): F1195-F1200. ( PubMed, DOI )

  139. Uchida Shinichi, Sohara Eisei, Rai Tatemitsu, Ikawa Masahito, Okabe Masaru, Sasaki Sei. Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2. Mol Cell Biol. 2005.08; 25 (16): 7357-7363. ( PubMed, DOI )

  140. Yamauchi Kozue, Yang Sung-Sen, Ohta Akihito, Sohara Eisei, Rai Tatemitsu, Sasaki Sei, Uchida Shinichi. Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice. Biochem Biophys Res Commun. 2005.07; 332 (3): 750-755. ( PubMed, DOI )

  141. Yang Sung-Sen, Yamauchi Kozue, Rai Tatemitsu, Hiyama Atsushi, Sohara Eisei, Suzuki Tatsunori, Itoh Tomohiro, Suda Shin, Sasaki Sei, Uchida Shinichi. Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells. Biochem Biophys Res Commun. 2005.05; 330 (2): 410-414. ( PubMed, DOI )

  142. Hara-Chikuma Mariko, Sohara Eisei, Rai Tatemitsu, Ikawa Masahito, Okabe Masaru, Sasaki Sei, Uchida Shinichi, Verkman A S. Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation. J Biol Chem. 2005.04; 280 (16): 15493-15496. ( PubMed, DOI )

  143. Yamauchi Kozue, Rai Tatemitsu, Kobayashi Katsuki, Sohara Eisei, Suzuki Tatsunori, Itoh Tomohiro, Suda Shin, Hayama Atsushi, Sasaki Sei, Uchida Shinichi. Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Proc Natl Acad Sci U S A. 2004.03; 101 (13): 4690-4694. ( PubMed, DOI )

▼display all

Conference Activities & Talks 【 display / non-display

  1. Eisei SOHARA. Understanding Cystic Kidney Disease by Comprehensive Genetic Panel Test 〜Emerging Role of Clinical Genetics in CKD〜 . JSN/ASN Joint Symposium, The 65th Annual Meeting of the Japanese Society of Nephrology 2022.06.11 Kobe, Japan

  2. Adya Saran Sinha , Wang Tianying, Hosoi Yasushi, Sohara Eisei, Akita Tenpei, Uchida Shinichi, Fukuda Atsuo. WNK3キナーゼはマウス内側前頭前野のV層錐体神経細胞における内向き整流と細胞内クロライドを調節することで興奮を維持する(WNK3 kinase maintains basal excitability by regulating inward rectification and intracellular chloride in layer V pyramidal neurons of mouse medial prefrontal cortex). The Journal of Physiological Sciences 2020.03.01

  3. Sohara Eisei. WNK signal in salt-sensitive hypertension. The 9th CKD Frontier Meetings 2020.02.15 Nagoya, Japan

  4. Sohara Eisei. Failure to sense energy depletion in chronic kidney disease.. The 42nd Annual Meeting of the Molecular Biology Society of Japan 2019.12.04 Kobe, Japan

  5. Sohara Eisei. Failure to sense energy depletion in chronic kidney disease.. The 6th Diabetes Research Innovation Symposium 2019 2019.07.14 Kyoto

  6. Eisei Sohara. WNK signaling in salt-sensitive hypertension and electrolyte disorder. JSN/ASN Joint Symposium, The 62nd Annual Meeting of the Japanese Society of Nephrology 2019.06.21

  7. EISEI SOHARA. Whole exome data in rare disease gene discovery. International Society of Nephrology, World Congress of Nephrology 2019 2019.04.15 Melbourne, Australia

  8. EISEI SOHARA. Failure to sense energy depletion in chronic kidney disease. The 9th Federation of the Asian and Oceanian Physiological Societies Congress 2019.03.30 Kobe, Hyogo, Japan

  9. Sohara E.. Pseudohypoaldosteronism. 10th International Meeting of Pediatric Endocrinology 2017.09.14 Washington, USA

  10. Sohara Eisei. WNK kinase signalling to cation chloride transporters. Symposium, INTERNATIONAL UNION OF PHYSIOLOGICAL SCIENCE, 38th World Congress 2017.08.05 Rio de Janeiro, Brazil

  11. Iimori S, Naito S, Sato H, Nomura N, Sohara E, Okado T, Uchida S, Rai T. Effects of proteinuria reduction on kidney function, mortality and cardiovascular risk in newly visiting CKD patients in Japan : the CKD-ROUTE study. The 6th CKD Frontier Meeting 2017.02.25 Nagoya, Japan

  12. Daiei Takahashi, Takayasu Mori, Eisei Sohara, Motoko Chiga, Yuichi Inoue, Naohiro Nomura, Moko Zeniya, Tatemitsu Rai, and Shinichi Uchida. WNK4 regulates adipocyte differentiation in 3T3-L1 cells. The 47th Annual Meeting of American Society of Nephrology 2016.11.19 Chicago, IL.

  13. Takuya Fujimaru, Takayasu Mori, Shintaro Mandai, Motoko Chiga, Hiroaki Kikuchi, Fumiaki Ando, Yutaro Mori, Naohiro Nomura, Shotaro Naito, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara. Development of a Customized Diagnostic Panel for Targeted Exome Sequencing of Polycystic Kidney Diseases. Kidney Week 2016 2016.11.19 Chicago, IL

  14. Emi Sasaki, Koichiro Susa, Takayasu Mori, Kiyoshi Isobe, Yuya Araki, Yuichi Inoue, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara. Generation and Analysis of KLHL3 Knockout Mice. The 49th Annual Meeting of American Society of nephrology 2016.11.18 Chicago

  15. Yuki Yoshizaki, Eisei Sohara, Takayasu Mori, Eriko Kikuchi, Daiei Takahashi, Moko Zeniya, Yuya Araki, Yutaro Mori, Fumiaki Ando, Tatemitsu Rai, Shinichi Uchida.. Drug Repositioning Screening for Keap1-Nrf2 Binding Inhibitors by Using Fluorescent Correlation Spectroscopy. The 49th Annual Meeting of American Society of Nephrology 2016.11.18 Chicago

  16. Wakana Shoda, Naohiro Nomura, Fumiaki Ando, Yutaro Mori, Takayasu Mori, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida. Calcineurin Rapidly Dephosphorylates Sodium-ChlorideCotransporter in Response to High Potassium Intake. The 49th Annual Meeting of American Society of nephrology. 2016.11.18 Chicago

  17. Yohei Arai, Eiichiro Kanda, Soichiro Iimori, Shotaro Naito, Yumi Noda, Sei Sasaki, Eisei Sohara, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida. Low White Blood Cell Count Is Independently Associated with the Progression of Chronic Kidney Disease in the Elderly: The CKD-ROUTE Study. The 49th Annual Meeting of American Society of Nephrology 2016.11.18 Chicago

  18. Yutaro Mori, Shintaro Mandai, Takayasu Mori, Eisei Sohara, Tatematsu Rai, Shinichi Uchida. Generation of p62/SQSTM1 (p62) KO Cell Lines Using CRISPR/Cas9 -The Role of p62 on WNK1 Regulation by Changes of Extracellular Potassium Concentration-. The 49th Annual Meeting of the American Society of Nephrology 2016.11.17 Chicago

  19. Hiroaki Kikuchi, Naohiro Nomura, Yoji Andrew Minamishima, Tatemitsu Rai, Shinichi Uchida and Eisei Sohara.. Targeted Metabolomic Analysis of Kidney from the Subtotal Nephrectomy Mouse Model of Chronic Kidney Disease. The 49th Annual Meeting of American Society of Nephrology. 2016.11.15 Chicago.

  20. Zeniya M, Mori T, Yui N, Nomura N, Chiga M, Sohara E, Rai T, Uchida S.. The proteasome inhibitor bortezomib attenuates renal fibrosis in mice.. The 49th Annual Meeting of American Society of Nephrology 2016.11.06 Chicago

  21. Ando F, Sohara E, Yui N, Nomura N, Kikuchi E, Takahashi D, Mori T, Rai T, Sasaki S, and Uchida S.. Calcineurin is a target for the treatment of nephrogenic diabetes insipidus. . 3rd Next Generation Kidney Research Meeting. 2016.08.16 Tokyo

  22. Wakana Shoda, Naofumi Yui, Shotaro Naito, Soichiro Iimori, Koichiro Susa, Takayasu Mori, Naohiro Nomura, Eisei Sohara, Tomokazu Okado, Tatemitsu Rai, Shinichi Uchida. Sunitinib-Induced Nephrotic Syndrome and Acute Kidney Injury in a Malignant Insulinoma Patient: A Case Report. The 48th Annual Meeting of American Society of Nephrology 2015.11.07 San Diego, USA

  23. Nomura Naohiro, Shoda Wakana, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi. Potassium-induced dephosphorylation of renal sodium-chloride cotransporter is NOT dependent on the anions. The 48th Annual Meeting of the American Society of Nephrology 2015.11.05 San Diego, USA

  24. Shotaro Naito, Soichiro Iimori, Eisei Sohara, Tomokazu Okado, Sei Sasaki, Shinichi Uchida, Tatemitsu Rai. The Effects of Diuretics on the Progression of CKD and Incidence of Cardiovascular Events: Results from the CKD-ROUTE Study – A Prospective Cohort Study of Newly Visiting CKD Patients in Japan. The 48th Annual Meeting of American Society of Nephrology 2015.11.05 San Diego, USA

  25. Kikuchi H, Kanda E, Iimori S, Naito S, Sasaki S, Sohara E, Okado T,Rai T,Uchida S. Combination of low body mass index and serum albumin level leads to chronic kidney disease progression: the chronic kidney disease–research of outcomes in treatment and epidemiology study. The 48th Annual Meeting of American Society of Nephrology 2015.11.05 San Diego, USA

  26. Susa Koichiro, Sohara Eisei, Takahashi Daiei, Rai Tatemitsu, Uchida Shinichi. The Major Contribution of WNK4 to the Pathogenesis of Pseudohypoaldosteronism Type II (PHAII) Caused by the KLHL3 Mutation R528H. The 48th Annual Meeting of American Society of Nephrology 2015.11.05 San Diego

  27. Mandai S, Mori T, Sohara E, Rai T, Uchida S. Generation of Hypertension-Associated STK39 Polymorphism Knockin Cell Lines with the CRISPR/Cas9 System. The 48th Annual Meeting of American Society of Nephrology 2015.11.05 San Diego

  28. Mandai S, Kanda E, Iimori S, Naito S, Sohara E, Okado T, Sasaki S, Rai T, Uchida S. Association of Serum Chloride Level with Mortality and Cardiovascular Events in Chronic Kidney Disease: The CKD-ROUTE Study. The 48th Annual Meeting of American Society of Nephrology 2015.11.05 San Diego

  29. Moko Zeniya, Nobuhisa Morimoto, Daiei Takahashi, Yutaro Mori, Takayasu Mori, Fumiaki Ando, Yuya Araki, Yuki Yoshizaki, Yuichi Inoue, Kiyoshi Ishobe, Naohiro Nomura, Katsuyuki Oi, Hidenori Nishida, Sei Sasaki, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida. KLHL2 mediates angiotensin II-WNK3 singaling involved in the regulation of vascular tonus. The 47th Annual Meeting of American Society of Nephrology 2014.11.15 Philadelphia

  30. Yutaro Mori, Mai Wakabayashi, Takayasu Mori, Moko Zeniya, Eisei Sohara, Tatemitsu Rai, Sei Sasaki, Shinichi Uchida. p62-mediated selective autophagy is involved in KLHL3-dependent WNK4 degradation . The 47th Annual Meeting of American Society of Nephrology 2014.11.15 Philadelphia

  31. Koichiro Susa, Eisei Sohara, Tatemitsu Rai, Moko Zeniya, Yutaro Mori, Takayasu Mori, Motoko Chiga, Daiei Takahashi, Yuichi Inoue, Kiyoshi Isobe, Naoki Takeda, Sei Sasaki, Shinichi Uchida. Molecular Pathogenesis of PHAII in KLHL3R528H/+ Knock-In Mice. The 47th Annual Meeting of American Society of Nephrology 2014.11.15 Philadelphia

  32. Yuichi Inoue, Eisei Sohara, Katsuki Kobayashi, Tatemitsu Rai, Kenichi Ishibashi, Shigeo Horie, Xuefeng Su, Jing Zhou, Sei Sasaki, Shinichi Uchida. Elongated ciliary length of proximal tubules in a PKD model AQP11 knockout mouse. . The 47th Annual Meeting of American Society of Nephrology 2014.11.14 Philadelphia

  33. Takayasu Mori, Kazuyoshi Hosomichi, Eisei Sohara, Tatemitsu Rai, Sei Sasaki, Ituro Inoue, Shinichi Uchida.. Comprehensive diagnosis of hereditary kidney diseases by a customized diagnostic panel of targeted exome sequencing.. The 47th Annual Meeting of the American Society of Nephrology 2014.11.05 Philadelphia

  34. Yuichi Inoue, Eisei Sohara, Katsuki Kobayashi, Motoko Chiga, Tatemitsu Rai, Kenichi Ishibashi, Shigeo Horie, Xuefeng Su, Jing Zhou, Sei Sasaki, Shinichi Uchida. Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in AQP11-knockout mice.. The 14th Asian Pacific Congress of Nephrology 2014.05.17 Tokyo

▼display all