Personnel Information

写真a

AKI Toshihiko


Job title

Associate Professor

Birth date

1967
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Graduating School 【 display / non-display 】

  • The University of Tokyo, Faculty of Liberal Arts, 1993, Graduated

  • The University of Tokyo, 1998, Graduated

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Degree 【 display / non-display 】

  • Ph. D.

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Campus Career 【 display / non-display 】

  • 1900.01
    -
    2016.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Public Health， Forensic Medicine， Junior Associate Professor
  • 2016.10
    -
    2018.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Public Health， Forensic Medicine， Associate Professor
  • 2018.04
    -
    2020.08
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Public Health， Forensic Medicine， Associate Professor
  • 2020.09
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Public Health， Forensic Medicine， Associate Professor
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Published Papers & Misc 【 display / non-display 】

  1. Moeka Nomura, Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Increased fatty acid synthesis and disturbed lipid metabolism in Neuro2a cells after repeated cocaine exposure: A preliminary study. Biochem Biophys Res Commun. 2023.12; 695 149438. ( PubMed, DOI )

  2. Kana Unuma, Shuheng Wen, Toshihiko Aki, Koichi Uemura. Ectopic myogenesis and fibrosis accompany adipogenesis during thymic involution induced by repeated cocaine administration. Biochem Biophys Res Commun. 2023.12; 686 149201. ( PubMed, DOI )

  3. Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Cocaine induces vascular smooth muscle cells proliferation via DRP1-mediated mitochondrial fission and PI3K/HIF-1α signaling. Biochem Biophys Res Commun. 2023.07; 676 30-35. ( PubMed, DOI )

  4. Toshihiko Aki, Hiroki Tanaka, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells. Biochem Biophys Res Commun. 2023.07; 676 66-72. ( PubMed, DOI )

  5. Toshihiko Aki, Mitsuki Kukita, Mao Takata, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Induction of filamin-C and its involvement in the regulation of cellular senescence and apoptosis in Huh-7 hepatoma cells during arsenic trioxide exposure. Biochem Biophys Res Commun. 2023.04; 651 92-97. ( PubMed, DOI )

  6. Miyu Komatsu, Takeshi Funakoshi, Toshihiko Aki, Kana Unuma, Koichi Uemura. Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells. Toxicol Lett. 2023.03; 378 39-50. ( PubMed, DOI )

  7. Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Contraction Band Necrosis with Dephosphorylated Connexin 43 in Rat Myocardium after Daily Cocaine Administration. Int J Mol Sci. 2022.10; 23 (19): ( PubMed, DOI )

  8. Shuheng Wen, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Role of Mitochondrial Dynamics in Cocaine's Neurotoxicity. Int J Mol Sci. 2022.05; 23 (10): ( PubMed, DOI )

  9. Toshihiko Aki, Kana Unuma, Koichi Uemura. The Role of Peroxiredoxins in the Regulation of Sepsis. Antioxidants (Basel). 2022.01; 11 (1): ( PubMed, DOI )

  10. Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Inverse regulation of GSDMD and GSDME gene expression during LPS-induced pyroptosis in RAW264.7 macrophage cells. Apoptosis. 2022.01; ( PubMed, DOI )

  11. Unuma K, Kaga H, Funakoshi T, Nomura M, Aki T, Uemura K. Thymic involution caused by repeated cocaine administration includes apoptotic cell loss followed by ectopic adipogenesis. PloS one. 2022; 17 (11): e0277032. ( PubMed, DOI )

  12. Sho Aoki, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Aggregation-prone A53T mutant of α-synuclein exaggerates methamphetamine neurotoxicity in SH-SY5Y cells: Protective role of cellular cholesterol. Toxicol Rep. 2022; 9 2020-2029. ( PubMed, DOI )

  13. Shuheng Wen, Kana Unuma, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura. Altered cardiac mitochondrial dynamics and biogenesis in rat after short-term cocaine administration. Sci Rep. 2021.12; 11 (1): 24129. ( PubMed, DOI )

  14. Toshihiko Aki, Koichi Uemura. Cell Death and Survival Pathways Involving ATM Protein Kinase. Genes (Basel). 2021.10; 12 (10): ( PubMed, DOI )

  15. Momoka Ota, Takeshi Funakoshi, Toshihiko Aki, Kana Unuma, Koichi Uemura. Oxcarbazepine induces mitotic catastrophe and apoptosis in NRK-52E proximal tubular cells. Toxicol Lett. 2021.07; 350 240-248. ( PubMed, DOI )

  16. Tatsuhiko Murata, Kanako Noritake, Toshihiko Aki, Koichi Uemura. Possible roles of AMPK and macropinocytosis in the defense responses against Δ 9-THC toxicity on HL-1 cardiomyocytes Toxicol Rep. 2021; 8 980-987. ( PubMed, DOI )

  17. Moeka Nomura, Kana Unuma, Toshihiko Aki, Koichi Uemura. Sustained splenic contraction after daily cocaine administration in rats. PLoS One. 2021; 16 (6): e0252853. ( PubMed, DOI )

  18. Toshihiko Aki, Takeshi Funakoshi, Kanako Noritake, Kana Unuma, Koichi Uemura. Extracellular glucose is crucially involved in the fate decision of LPS-stimulated RAW264.7 murine macrophage cells. Sci Rep. 2020.06; 10 (1): 10581. ( PubMed, DOI )

  19. Shuheng Wen, Toshihiko Aki, Kana Unuma, Koichi Uemura. Chemically Induced Models of Parkinson's Disease: History and Perspectives for the Involvement of Ferroptosis. Front Cell Neurosci. 2020; 14 581191. ( PubMed, DOI )

  20. Kana Unuma, Ayaka Yoshikawa, Toshihiko Aki, Koichi Uemura. Increased circulating peroxiredoxin-4 in sepsis model rats involves secretion from hepatocytes and is mitigated by GYY4137. J Toxicol Pathol. 2019.10; 32 (4): 305-310. ( PubMed, DOI )

  21. Takeshi Funakoshi, Mako Furukawa, Toshihiko Aki, Koichi Uemura. Repeated exposure of cocaine alters mitochondrial dynamics in mouse neuroblastoma Neuro2a. Neurotoxicology. 2019.09; ( PubMed, DOI )

  22. Kana Unuma, Toshihiko Aki, Ayaka Yamashita, Ayaka Yoshikawa, Koichi Uemura. Hydrogen sulfide donor NaHS causes bronchitis with enhanced respiratory secretion in rats. J Toxicol Sci. 2019; 44 (2): 107-112. ( PubMed, DOI )

  23. Toshihiko Aki, Kana Unuma, Kanako Noritake, Naho Hirayama, Takeshi Funakoshi, Koichi Uemura. Formation of high molecular weight p62 by CORM-3. PLoS ONE. 2019; 14 (1): e0210474. ( PubMed, DOI )

  24. Toshihiko Aki, Kana Unuma, Kanako Noritake, Hatsumi Kurahashi, Takeshi Funakoshi, Koichi Uemura. Interaction of carbon monoxide-releasing ruthenium carbonyl CORM-3 with plasma fibronectin. Toxicol In Vitro. 2018.03; 50 201-209. ( PubMed, DOI )

  25. Naho Hirayama, Toshihiko Aki, Takeshi Funakoshi, Kanako Noritake, Kana Unuma, Koichi Uemura. Necrosis in human neuronal cells exposed to paraquat. J Toxicol Sci. 2018.03; 43 (3): 193-202. ( PubMed, DOI )

  26. Kana Unuma, Toshihiko Aki, Suguru Nagano, Ryo Watanabe, Koichi Uemura. The down-regulation of cardiac contractile proteins underlies myocardial depression during sepsis and is mitigated by carbon monoxide. Biochem. Biophys. Res. Commun.. 2018.01; 495 (2): 1668-1674. ( PubMed, DOI )

  27. Toshihiko Aki, Kanako Noritake, Takeshi Funakoshi, Koichi Uemura.. Modes of Chemically Induced Cell Death. Comprehensive Toxicology 3rd ed Volume 1 (General subjects). 2017.12;

  28. Toshihiko Aki, Kana Unuma, and Koichi Uemura. Emerging roles of mitochondria and autophagy in liver injury during sepsis. Cell Stress. 2017.11; 1 (2): 79-89.

  29. Kanako Noritake, Toshihiko Aki, Moe Kimura, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Restoration of YAP activation rescues HL-1 cardiomyocytes from apoptotic death by ethanol. J Toxicol Sci. 2017.10; 42 (5): 545-551. ( PubMed, DOI )

  30. Ryo Watanabe, Kana Unuma, Kanako Noritake, Takeshi Funakoshi, Toshihiko Aki, Koichi Uemura.. Ataxia telangiectasia and rad3 related (ATR)-promyelocytic leukemia protein (PML) pathway of the DNA damage response in the brain of rats administered arsenic trioxide. J. Toxicologic Pathology. 2017.07; 30 333-337.

  31. Kana Unuma, Toshihiko Aki, Kanako Noritake, Takeshi Funakoshi, Koichi Uemura. A CO-releasing molecule prevents annexin A2 down-regulation and associated disorders in LPS-administered rat lung. Biochem. Biophys. Res. Commun.. 2017.06; 487 (3): 748-754. ( PubMed, DOI )

  32. Takeshi Funakoshi, Toshihiko Aki, Masateru Tajiri, Kana Unuma, Koichi Uemura. Necroptosis-like Neuronal Cell Death Caused by Cellular Cholesterol Accumulation. J. Biol. Chem.. 2016.11; 291 (48): 25050-25065. ( PubMed, DOI )

  33. Haruka Kimura-Kojima, Kana Unuma, Takeshi Funakoshi, Chizuru Kato, Ayumi Komatsu, Toshihiko Aki, Koichi Uemura. Increased MFG-E8 expression and its implications in the vascular pathophysiology of cocaine abuse. J Toxicol Pathol. 2016.04; 29 (2): 131-138. ( PubMed, DOI )

  34. Yusuke Fujii, Takeshi Funakoshi, Kana Unuma, Kanako Noritake, Toshihiko Aki, Koichi Uemura. Hydrogen sulfide donor NaHS induces death of alveolar epithelial L2 cells that is associated with cellular shrinkage, transgelin expression and myosin phosphorylation. J Toxicol Sci. 2016; 41 (5): 645-654. ( PubMed, DOI )

  35. 則竹 香菜子, 秋 利彦, 上村 公一. アルコールによる心筋障害とオートファジーの役割 月刊「細胞」. 2015.12; 47 (14): 44-47.

  36. Toshihiko Aki, Takeshi Funakoshi, Koichi Uemura. Regulated necrosis and its implications in toxicology. Toxicology. 2015.07; 333 118-126. ( PubMed, DOI )

  37. Sayuri Okawa, Kana Unuma, Atsushi Yamada, Toshihiko Aki, Koichi Uemura. Lipopolysaccharide induces expression of collagen VI in the rat lung. J Toxicol Pathol. 2015.01; 28 (1): 37-41. ( PubMed, DOI )

  38. Kanako Noritake, Toshihiko Aki, Takeshi Funakoshi, Kana Unuma, Koichi Uemura. Direct Exposure to Ethanol Disrupts Junctional Cell-Cell Contact and Hippo-YAP Signaling in HL-1 Murine Atrial Cardiomyocytes. PLoS ONE. 2015; 10 (8): e0136952. ( PubMed, DOI )

  39. Atsushi Yamada, Toshihiko Aki, Kana Unuma, Takeshi Funakoshi, Koichi Uemura. Paraquat induces epithelial-mesenchymal transition-like cellular response resulting in fibrogenesis and the prevention of apoptosis in human pulmonary epithelial cells. PLoS ONE. 2015; 10 (3): e0120192. ( PubMed, DOI )

  40. Kana Unuma, Toshihiko Aki, Takeshi Funakoshi, Kyoko Hashimoto, Koichi Uemura. Extrusion of mitochondrial contents from lipopolysaccharide-stimulated cells: Involvement of autophagy. Autophagy. 2015; 11 (9): 1520-1536. ( PubMed, DOI )

  41. Nara A, Aki T, Funakoshi T, Uemura K. Methamphetamine induces macropinocytosis in differentiated SH-SY5Y human neuroblastoma cells. Brain Res. 2010.09; 1352 1-10. ( PubMed, DOI )

  42. Aki T, Nara A, Funakoshi T, Uemura K. Bifurcate effects of glucose on caspase-independent cell death during hypoxia. Biochem Biophys Res Commun. 2010.06; 396 (3): 614-618. ( PubMed, DOI )

  43. Nara A, Aki T, Funakoshi T, Uchida K, Nakayama H, Uemura K. Death due to blood transfusion-induced anaphylactic shock: A case report. Leg Med (Tokyo). 2010.05; 12 (3): 148-150. ( PubMed, DOI )

  44. Aki T, Yanagisawa S. Application of rice nuclear proteome analysis to the identification of evolutionarily conserved and glucose-responsive nuclear proteins. J Proteome Res. 2009.08; 8 (8): 3912-3924. ( PubMed, DOI )

  45. Aki T, Funakoshi T, Nishida-Kitayama J, Mizukami Y. TPRA40/GPR175 regulates early mouse embryogenesis through functional membrane transport by Sjögren's syndrome-associated protein NA14. J Cell Physiol. 2008.10; 217 (1): 194-206. ( PubMed, DOI )

  46. Mizukami Y, Ono K, Du CK, Aki T, Hatano N, Okamoto Y, Ikeda Y, Ito H, Hamano K, Morimoto S. Identification and physiological activity of survival factor released from cardiomyocytes during ischaemia and reperfusion. Cardiovasc Res. 2008.09; 79 (4): 589-599. ( PubMed, DOI )

  47. Aki T, Shigyo M, Nakano R, Yoneyama T, Yanagisawa S. Nano scale proteomics revealed the presence of regulatory proteins including three FT-Like proteins in phloem and xylem saps from rice. Plant Cell Physiol. 2008.05; 49 (5): 767-790. ( PubMed, DOI )

  48. Aki T, Konishi M, Kikuchi T, Fujimori T, Yoneyama T, Yanagisawa S. Distinct modulations of the hexokinase1-mediated glucose response and hexokinase1-independent processes by HYS1/CPR5 in Arabidopsis. J Exp Bot. 2007; 58 (12): 3239-3248. ( PubMed, DOI )

  49. Hara K, Okamoto M, Aki T, Yagita H, Tanaka H, Mizukami Y, Nakamura H, Tomoda A, Hamasaki N, Kang D. Synergistic enhancement of TRAIL- and tumor necrosis factor alpha-induced cell death by a phenoxazine derivative. Mol Cancer Ther. 2005.07; 4 (7): 1121-1127. ( PubMed, DOI )

  50. Mizukami Y, Iwamatsu A, Aki T, Kimura M, Nakamura K, Nao T, Okusa T, Matsuzaki M, Yoshida K, Kobayashi S. ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation. J Biol Chem. 2004.11; 279 (48): 50120-50131. ( PubMed, DOI )

  51. Aki T, Yoshida K, Mizukami Y. The mechanism of alphaB-crystallin gene expression by proteasome inhibition. Biochem Biophys Res Commun. 2003.11; 311 (1): 162-167. ( PubMed )

  52. Aki T, Yamaguchi K, Fujimiya T, Mizukami Y. Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2. Oncogene. 2003.11; 22 (52): 8529-8535. ( PubMed, DOI )

  53. Claeyssens S, Gangneux C, Brasse-Lagnel C, Ruminy P, Aki T, Lavoinne A, Salier JP. Amino acid control of the human glyceraldehyde 3-phosphate dehydrogenase gene transcription in hepatocyte. Am J Physiol Gastrointest Liver Physiol. 2003.11; 285 (5): G840-9. ( PubMed, DOI )

  54. Fujimiya T, Ohbora Y, Shinagawa H, Aki T. Pharmacokinetic study of ethanol and its metabolites during ethanol infusion. Leg Med (Tokyo). 2003.03; 5 Suppl 1 S126-8. ( PubMed )

  55. Fujimiya T, Shinagawa H, Ohbora Y, Aki T. Pharmacokinetic study of ethanol and its metabolites in culture cells. Leg Med (Tokyo). 2003.03; 5 Suppl 1 S123-5. ( PubMed )

  56. Uemura K, Aki T, Yamaguchi K, Yoshida K. Protein kinase C-epsilon protects PC12 cells against methamphetamine-induced death: possible involvement of suppression of glutamate receptor. Life Sci. 2003.02; 72 (14): 1595-1607. ( PubMed )

  57. Aki T, Yoshida K, Fujimiya T. Phosphoinositide 3-kinase accelerates calpain-dependent proteolysis of fodrin during hypoxic cell death. J Biochem. 2002.12; 132 (6): 921-926. ( PubMed )

  58. Fujimiya T, Yamaoka K, Ohbora Y, Aki T, Shinagawa H. Michaelis-Menten elimination kinetics of acetaldehyde during ethanol oxidation. Alcohol Clin Exp Res. 2002.08; 26 (8 Suppl): 49S-54S. ( PubMed, DOI )

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Books etc 【 display / non-display 】

  1. Toshihiko Aki, Kanako Noritake, Kana Unuma, and Koichi Uemura. “Autophagy in health and disease”, “Stem Cell Biology and Regenerative Medicine” book series. Humana press, Springer-Nature， 2018 Autophagic regulation of cardiomyocyte survival and heart regeneration. (ISBN : 978-3-319-98145-1)

  2. Toshihiko Aki, Kanako Noritake, Takeshi Funakoshi, Koichi Uemura.. Comprehensive Toxicology 3rd ed Volume 1. Elsevier UK， 2018 Modes of Chemically Induced Cell Death. (ISBN : 9780081006016)

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Conference Activities & Talks 【 display / non-display 】

  1. 船越丈司、古川真子、秋利彦、上村公一. コカイン長期曝露による神経細胞ミトコンドリアダイナミクスへの影響. 第42回日本分子生物学会年会 2019.12 福岡

  2. 渡邊 嶺、鵜沼 香奈、秋 利彦、上村 公一. . ラット脳組織における三酸化二ヒ素のPML及びDNA損傷チェックポイント機構への影響.. 第91回日本生化学会大会 2018.09 京都

  3. Rina Kaseda, Toshihiko Aki, Koichi Uemura. SH-SY5Y human neuroblastoma cell death by methamphetamine involves downregulation of cell cycle regulators. IALM 2018 2018.06.08

  4. Kana Unuma, Toshihiko Aki, Ryo Watanabe, Koichi Uemura. Down-regulation of cardiac contractile protein is involved in cardiac dysfunction during sepsis and is mitigated by carbon monoxide. IALM 2018 2018.06.08

  5. Naho Hirayama, Toshihiko Aki, Koichi Uemura. Paraquat-induced cell death pathway, mmitochondrial stress and autophagy in human neuronal cell line SH-SY5Y.. IALM 2018 2018.06.06

  6. Noritake K, Aki T, Uemura K. Ethanol induces apoptosis with alterations of Cx43 expression and distribution in HL-1 cells.. 9th International Symposium on Advances in Legal Medicine 2014.06

  7. Yamada A, Aki T, Uemura K. Differential induction of epithelial-mesenchymal transition and cell death during paraquat poisoning in human alveolar cell line A549.. 9th International Symposium on Advances in Legal Medicine 2014.06

  8. Kana Unuma, Toshihiko Aki, Takeshi Funakoshi, Koichi Uemura. Secretion of mitochondrial contents through autophagolysosomal exocytosis from lipopolysaccharide-stimulated hepatocytes and embryonic fibroblasts.. 9th International Symposium on Advances in Legal Medicine 2014.06 Fukuoka,Japan

  9. Watanabe M, Funakoshi T, Unuma K, Aki T, Uemura K. Activation of ubiquitin-proteasome system plays a protective role in arsenic trioxide-induced cardiotoxicity. 9th International Symposium on Advances in Legal Medicine

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