基本情報

写真a

澤野　頼子(サワノ　ヨリコ)

SAWANO Yoriko


職名

准教授

生年

1973年

研究室住所

東京医科歯科大学教養部　千葉県市川市国府台2-8-30

研究室電話番号

047-300-7123

メールアドレス

メールによる問い合わせは《こちら》から
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出身大学院 【 表示 ／ 非表示 】

  • 東京大学  農学生命科学研究科  応用生命工学専攻  修士課程  修了

  • 東京大学  農学生命科学研究科  応用生命工学専攻  博士課程  修了

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取得学位 【 表示 ／ 非表示 】

  • 博士（農学）  東京大学

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経歴(学内) 【 表示 ／ 非表示 】

  • 2010年04月
    -
    2022年03月
    東京医科歯科大学 教養部 自然科学系 化学 准教授
  • 2022年04月
    　
    　
    東京医科歯科大学 統合教育機構 教養教育部門 准教授
  • 2022年05月
    　
    　
    東京医科歯科大学 統合教育機構 教養教育部門 准教授
  • 2022年06月
    -
    現在
    東京医科歯科大学 統合教育機構 教養教育部門 准教授
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所属学協会 【 表示 ／ 非表示 】

  • 農芸化学会

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競争的資金等の研究課題 【 表示 ／ 非表示 】

  • 乾燥耐性植物の育種に向けたアブシジン酸シグナル伝達因子の立体構造に基づく分子改変

    文部科学省/日本学術振興会 : 2013年 - 2014年

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論文・総説 【 表示 ／ 非表示 】

  1. Hui-Min Qin, Takuya Miyakawa, Akira Inoue, Ryuji Nishiyama, Akira Nakamura, Atsuko Asano, Yoriko Sawano, Takao Ojima, Masaru Tanokura. Structure and Polymannuronate Specificity of a Eukaryotic Member of Polysaccharide Lyase Family 14. J. Biol. Chem.. 2017.02; 292 (6): 2182-2190. ( PubMed, DOI )

  2. Hai Zheng, Takuya Miyakawa, Yoriko Sawano, Atsuko Asano, Akinori Okumura, Satoshi Yamagoe, Masaru Tanokura. Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold. J. Biol. Chem.. 2016.08; 291 (33): 17133-17142. ( PubMed, DOI )

  3. You-Lin Xue, Takuya Miyakawa, Akira Nakamura, Ken-Ichi Hatano, Yoriko Sawano, Masaru Tanokura. Yam Tuber Storage Protein Reduces Plant Oxidants Using the Coupled Reactions as Carbonic Anhydrase and Dehydroascorbate Reductase. Mol Plant. 2015.07; 8 (7): 1115-1118. ( PubMed, DOI )

  4. Takuya Miyakawa, Ken-ichi Hatano, Yumiko Miyauchi, You-ichi Suwa, Yoriko Sawano, Masaru Tanokura. A secreted protein with plant-specific cysteine-rich motif functions as a mannose-binding lectin that exhibits antifungal activity. Plant Physiol.. 2014.10; 166 (2): 766-778. ( PubMed, DOI )

  5. Nanao Suzuki, Syoko Ban, Eriko Itoh, Sisi Chen, Fabiana L Imai, Yoriko Sawano, Takuya Miyakawa, Masaru Tanokura, Naoto Yonezawa. Calcium-dependent structural changes in human reticulocalbin-1. J. Biochem.. 2014.05; 155 (5): 281-293. ( PubMed, DOI )

  6. Takuya Miyakawa, Yoriko Sawano, Ken-ichi Miyazono, Yumiko Miyauchi, Ken-ichi Hatano, Masaru Tanokura. A thermoacidophile-specific protein family, DUF3211, functions as a fatty acid carrier with novel binding mode. J. Bacteriol.. 2013.09; 195 (17): 4005-4012. ( PubMed, DOI )

  7. Hai Zheng, Takuya Miyakawa, Yoriko Sawano, Satoshi Yamagoe, Masaru Tanokura. Expression, high-pressure refolding and purification of human leukocyte cell-derived chemotaxin 2 (LECT2). Protein Expr. Purif.. 2013.04; 88 (2): 221-229. ( PubMed, DOI )

  8. Hai Zheng, Takuya Miyakawa, Yoriko Sawano, Satoshi Yamagoe, Masaru Tanokura. Crystallization and preliminary X-ray analysis of human leukocyte cell-derived chemotaxin 2 (LECT2). Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.. 2013.03; 69 (Pt 3): 316-319. ( PubMed, DOI )

  9. Yusuke S Kato, Fumiaki Yumoto, Hiroyuki Tanaka, Takuya Miyakawa, Yumiko Miyauchi, Daijiro Takeshita, Yoriko Sawano, Takao Ojima, Iwao Ohtsuki, Masaru Tanokura. Structure of the Ca(2+)-saturated C-terminal domain of scallop troponin C in complex with a troponin I fragment. Biol. Chem.. 2013.01; 394 (1): 55-68. ( PubMed, DOI )

  10. Yoichi Suwa, Jun Ohtsuka, Takuya Miyakawa, Fabiana Lica Imai, Masahiko Okai, Yoriko Sawano, Yoshihiko Yasohara, Michihiko Kataoka, Sakayu Shimizu, Masaru Tanokura. Expression, purification, crystallization and preliminary X-ray analysis of carbonyl reductase S1 from Candida magnoliae. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.. 2012.05; 68 (Pt 5): 540-542. ( PubMed, DOI )

  11. You-Lin Xue, Takuya Miyakawa, Yoriko Sawano, Masaru Tanokura. Crystallization and preliminary X-ray crystallographic analysis of dioscorin from Dioscorea japonica. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.. 2012.02; 68 (Pt 2): 193-195. ( PubMed, DOI )

  12. You-Lin Xue, Takuya Miyakawa, Yoriko Sawano, Masaru Tanokura. Cloning of genes and enzymatic characterizations of novel dioscorin isoforms from Dioscorea japonica. Plant Sci.. 2012.02; 183 14-19. ( PubMed, DOI )

  13. You-Lin Xue, Takuya Miyakawa, Yasuna Hayashi, Kyoko Okamoto, Fangyu Hu, Nobuhito Mitani, Kazuo Furihata, Yoriko Sawano, Masaru Tanokura. Isolation and tyrosinase inhibitory effects of polyphenols from the leaves of persimmon, Diospyros kaki. J. Agric. Food Chem.. 2011.06; 59 (11): 6011-6017. ( PubMed, DOI )

  14. You-Lin Xue, Tomoyuki Ahiko, Takuya Miyakawa, Hisako Amino, Fangyu Hu, Kazuo Furihata, Kiyoshi Kita, Takuji Shirasawa, Yoriko Sawano, Masaru Tanokura. Isolation and Caenorhabditis elegans lifespan assay of flavonoids from onion. J. Agric. Food Chem.. 2011.06; 59 (11): 5927-5934. ( PubMed, DOI )

  15. Jun Lu, Yoriko Sawano, Takuya Miyakawa, You-Lin Xue, Mu-Yi Cai, Yukari Egashira, Di-Feng Ren, Masaru Tanokura. One-week antihypertensive effect of Ile-Gln-Pro in spontaneously hypertensive rats. J. Agric. Food Chem.. 2011.01; 59 (2): 559-563. ( PubMed, DOI )

  16. Lu J, Ren DF, Xue YL, Sawano Y, Miyakawa T, Tanokura M. Isolation of an antihypertensive peptide from alcalase digest of Spirulina platensis. J Agric Food Chem. 2010.06; 58 (12): 7166-7171. ( PubMed, DOI )

  17. Miyazono K, Miyakawa T, Sawano Y, Kubota K, Kang HJ, Asano A, Miyauchi Y, Takahashi M, Zhi Y, Fujita Y, Yoshida T, Kodaira KS, Yamaguchi-Shinozaki K, Tanokura M. Structural basis of abscisic acid signalling. Nature. 2009.12; 462 (7273): 609-614. ( PubMed, DOI )

  18. Miyakawa T, Miyazono K, Sawano Y, Hatano K, Tanokura M. Crystal structure of ginkbilobin-2 with homology to the extracellular domain of plant cysteine-rich receptor-like kinases. Proteins. 2009.10; 77 (1): 247-251. ( PubMed, DOI )

  19. Ano Y, Nakayama H, Sakudo A, Sawano Y, Tanokura M, Itohara S, Onodera T. Intestinal uptake of amyloid beta protein through columnar epithelial cells in suckling mice. Histol Histopathol. 2009.03; 24 (3): 283-292. ( PubMed )

  20. Miyazono K, Shirokane M, Sawano Y, Tanokura M. Crystal structure of the DUF54 family protein PH1010 from hyperthermophilic archaea Pyrococcus horikoshii OT3. Proteins. 2009.01; 74 (1): 256-260. ( PubMed, DOI )

  21. Sawano Y, Hatano K, Miyakawa T, Tanokura M. Absolute side-chain structure at position 13 is required for the inhibitory activity of bromein. J Biol Chem. 2008.12; 283 (52): 36338-36343. ( PubMed, DOI )

  22. Miyazono K, Nishimura Y, Sawano Y, Makino T, Tanokura M. Crystal structure of hypothetical protein PH0734.1 from hyperthermophilic archaea Pyrococcus horikoshii OT3. Proteins. 2008.12; 73 (4): 1068-1071. ( PubMed, DOI )

  23. Qin F, Sakuma Y, Tran LS, Maruyama K, Kidokoro S, Fujita Y, Fujita M, Umezawa T, Sawano Y, Miyazono K, Tanokura M, Shinozaki K, Yamaguchi-Shinozaki K. Arabidopsis DREB2A-interacting proteins function as RING E3 ligases and negatively regulate plant drought stress-responsive gene expression. Plant Cell. 2008.06; 20 (6): 1693-1707. ( PubMed, DOI )

  24. Kanai S, Kitayama T, Yonezawa N, Sawano Y, Tanokura M, Nakano M. Disulfide linkage patterns of pig zona pellucida glycoproteins ZP3 and ZP4. Mol Reprod Dev. 2008.05; 75 (5): 847-856. ( PubMed, DOI )

  25. Sawano Y, Hatano K, Miyakawa T, Komagata H, Miyauchi Y, Yamazaki H, Tanokura M. Proteinase inhibitor from ginkgo seeds is a member of the plant nonspecific lipid transfer protein gene family. Plant Physiol. 2008.04; 146 (4): 1909-1919. ( PubMed, DOI )

  26. Miyakawa T, Sawano Y, Miyazono K, Hatano K, Tanokura M. Crystallization and preliminary X-ray analysis of ginkbilobin-2 from Ginkgo biloba seeds: a novel antifungal protein with homology to the extracellular domain of plant cysteine-rich receptor-like kinases. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007.09; 63 (Pt 9): 737-739. ( PubMed, DOI )

  27. Shirokane M, Sawano Y, Miyazono KI, Nagata K, Tanokura M. Crystallization and preliminary X-ray analysis of PH1010 from Pyrococcus horikoshii OT3, a member of the archaeal DUF54 family of proteins. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007.06; 63 (Pt 6): 532-534. ( PubMed, DOI )

  28. Sawano Y, Miyakawa T, Yamazaki H, Tanokura M, Hatano K. Purification, characterization, and molecular gene cloning of an antifungal protein from Ginkgo biloba seeds. Biol Chem. 2007.03; 388 (3): 273-280. ( PubMed, DOI )

  29. Hatano K, Sawano Y, Miyakawa T, Tanokura M. Characterization of the acidic and basic limbs of a bell-shaped pH profile in the inhibitory activity of bromelain inhibitor VI. Biopolymers. 2006.03; 81 (4): 309-319. ( PubMed, DOI )

  30. Miyakawa T, Lee WC, Hatano K, Kato Y, Sawano Y, Miyazono K, Nagata K, Tanokura M. Crystal structure of the YjgF/YER057c/UK114 family protein from the hyperthermophilic archaeon Sulfolobus tokodaii strain 7. Proteins. 2006.02; 62 (2): 557-561. ( PubMed, DOI )

  31. Kato Y, Sawano Y, Tanokura M. Expression and purification of active WW domains of FBP11/HYPA and FBP28/CA150. Protein Pept Lett. 2006; 13 (2): 197-201. ( PubMed )

  32. Oroguchi T, Ikeguchi M, Saeki K, Kamagata K, Sawano Y, Tanokura M, Kidera A, Kuwajima K. Atomically detailed description of the unfolding of alpha-lactalbumin by the combined use of experiments and simulations. J Mol Biol. 2005.11; 354 (1): 164-172. ( PubMed, DOI )

  33. Miyazono K, Sawano Y, Tanokura M. Crystal structure and structural stability of acylphosphatase from hyperthermophilic archaeon Pyrococcus horikoshii OT3. Proteins. 2005.10; 61 (1): 196-205. ( PubMed, DOI )

  34. Miyakawa T, Hatano KI, Lee WC, Kato Y, Sawano Y, Yumoto F, Nagata K, Tanokura M. Crystallization and preliminary X-ray analysis of the YjgF/YER057c/UK114-family protein ST0811 from Sulfolobus tokodaii strain 7. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005.09; 61 (Pt 9): 828-830. ( PubMed, DOI )

  35. Sawano Y, Hatano K, Tanokura M. Susceptibility of the interchain peptide of a bromelain inhibitor precursor to the target proteases bromelain, chymotrypsin, and trypsin. Biol Chem. 2005.05; 386 (5): 491-498. ( PubMed, DOI )

  36. Kamagata K, Sawano Y, Tanokura M, Kuwajima K. Multiple parallel-pathway folding of proline-free Staphylococcal nuclease. J Mol Biol. 2003.10; 332 (5): 1143-1153. ( PubMed )

  37. Sawano Y, Muramatsu T, Hatano K, Nagata K, Tanokura M. Characterization of genomic sequence coding for bromelain inhibitors in pineapple and expression of its recombinant isoform. J Biol Chem. 2002.08; 277 (31): 28222-28227. ( PubMed, DOI )

  38. Hatano K, Sawano Y, Tanokura M. Structure-function relationship of bromelain isoinhibitors from pineapple stem. Biol Chem. 2002.07; 383 (7-8): 1151-1156. ( PubMed, DOI )

  39. 奈良雅之，澤野頼子，勝又敏行. 公開講座『親子で楽しい理科教室』を実践して 東京医科歯科大学教養部研究紀要. 2018.03; (48): 37-46.

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担当授業科目(学内) 【 表示 ／ 非表示 】

  • 生化学入門，2010年

  • 一般化学基礎，2010年

  • 化学基礎入門，2010年

  • タンパク質の科学，2010年

  • 化学基礎，2010年

  • 化学実験，2010年

  • 科学基礎実験A，2010年

  • 科学基礎実験B，2010年

  • 科学基礎実験C，2010年

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