Personnel Information

写真a

NOBUHISA Ikuo


Job title

Associate Professor

Birth date

1970

Laboratory Address

1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan

Mail Address

The inquiry by e-mail is 《here

Homepage URL

http://www.tmd.ac.jp/mri/scr/english/index.html

Research Areas, Keywords

hematopoiesis

Graduating School 【 display / non-display

  • Kyushu University, Faculty of Science, 1993.03, Graduated

Graduate School 【 display / non-display

  • Kyushu University, Graduate School, Division of Natural Science, Department of Chemistry, Master's Course, 1995.03, Completed

  • Kyushu University, Graduate School, Division of Natural Science, Department of Chemistry, Doctor's Course, 1998.03, Completed

Degree 【 display / non-display

  • Ph.D., Kyushu University

Campus Career 【 display / non-display

  • 2009.04
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Advanced Molecular Medicine, Stem Cell Regulation, Associate Professor
  • 2009.04
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Stem Cell Regulation, Associate Professor

External Career 【 display / non-display

  • 1995.04
    -
    1998.03
    , JSPS Research Fellow
  • 1998.04
    -
    2000.07
    , JSPS Research Fellow
  • 2000.08
    -
    2005.03
    Kumamoto University, Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics,
  • 2005.04
    -
    2009.03
    Kumamoto University, Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Junior Associate Professor

Research Areas 【 display / non-display

  • Molecular biology

  • Cell biology

  • Developmental biology

 

Published Papers & Misc 【 display / non-display

  • Takahashi S, Nobuhisa I, Saito K, Melig G, Itabashi A, Harada K, Osawa M, Endo AT, Iwama A,Taga T. Sox17-mediated expression of adherent molecules is required for the maintenance of undifferentiated hematopoietic cluster formation in midgestation mouse embryos Differentiation. 2020.09; 115 53-61. ( DOI )

  • Tabu K, Liu W, Kosaku A, Terashima K, Murota Y, Aimaitijiang A, Nobuhisa I, Hide T, Taga T. Glioma stem cell (GSC)-derived autoschizis-like products confer GSC niche properties involving M1-like tumor-associated macrophages. Stem cells (Dayton, Ohio). 2020.08; 38 (8): 921-935. ( PubMed, DOI )

  • Saito K, Nobuhisa I, Harada K, Takahashi S, Anani M, Lickert H, Kanai-Azuma M, Kanai Y, and Taga T . Maintenance of hematopoietic stem and progenitor cells in fetal intra-aortic hematopoietic clusters by the Sox17-Notch1-Hes1 axis Exp Cell Res. 2018.04; 365 (1): 145-155. ( DOI )

  • Harada K, Nobuhisa I, Anani M, Saito K, Taga T. Thrombopoietin contributes to the formation and the maintenance of hematopoietic progenitor-containing cell clusters in the aorta-gonad-mesonephros region. Cytokine. 2017.07; 95 32-42. ( PubMed, DOI )

  • Kouichi Tabu, Nozomi Muramatsu, Christian Mangani, Mei Wu, Rong Zhang, Taichi Kimura, Kazuo Terashima, Norihisa Bizen, Ryosuke Kimura, Wenqian Wang, Yoshitaka Murota, Yasuhiro Kokubu, Ikuo Nobuhisa, Tetsushi Kagawa, Issay Kitabayashi, Mark Bradley and Tetsuya Taga. A synthetic polymer scaffold reveals the self-maintenance strategies of rat glioma stem cells by organization of the advantageous niche. Stem Cells. 2016.05; 34 1151-1162. ( DOI )

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Conference Activities & Talks 【 display / non-display

  • Alapati Aimaitijiang, Kouichi Tabu, Wenqian Wang, Ikuo Nobuhisa and Tetsuya Taga. Glioma stem cells promote erythroid differentiation in mouse bone marrow. 第41回日本炎症・再生医学会シンポジウム「炎症と発癌・転移の最前線」 2020.07.08

  • Ayumi Itabashi, Ikuo Nobuhisa, Yuki Yokoi, Kiyoka Saito, Ryota Tsukahara, Gerel Melig, Tetsuya Taga. Formation of hematopoietic cell clusters and maintenance of undifferentiated state by forced expression of transcription factor Sox17 in a cell population containing hematopoietic stem cells of mouse fetal liver and adult bone marrow. 2020.07.08

  • Gerel Melig, Ikuo Nobuhisa, Saito Kiyoka, Ryota Tsukahara, Ayumi Itabashi, Yoshiakira Kanai, Masami Kanai, Tetsuya Taga. Role of the Rasip1 in the hematopoiesis of HSC-containing hematopoietic cluster cells in midgestation of mouse embryos. 2020.07.08

  • Ikuo Nobuhisa, Ryota Tsukahara, Kiyoka Saito, Yoshiakira Kanai, Masami Kanai, Tetsuya Taga. Contribution of GIMAP6 expression mediated by transcription factor Sox17 to hematopoietic ability in the aortic lumen of midgestation mouse embryos. The 41th Annual Meeting of the Japanese Society of Inflammation and Regeneration 2020.07.08

  • Nobuhisa I, Saito K, Tsukahara R, Azuma K, Melig G, Itabashi A, Taga T. Involvement of TET1 in the maintenance of the hematopoietic capacity in hematopoietic cell clusters in the dorsal aorta in midgestation mouse embryo. The 48th Annual Meeting of The Japanese Society for Immunology 2019.12.11 Act City Hamamatsu, Hamamatsu, Japan

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