Personnel Information

写真a

KAWACHI Hiroshi


Job title

Visiting Lecturer

Birth date

1972

Mail Address

The inquiry by e-mail is 《here》

Research Areas, Keywords

Gastrointestinal tract, esophagus, stomach, colon and rectum, cancer
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Graduating School 【 display / non-display 】

  • Tokyo Medical and Dental University, Faculty of Medicine, 1998, Graduated

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Graduate School 【 display / non-display 】

  • Tokyo Medical and Dental University, Graduate School, Division of Medical Sciences, Pathology, Doctor's Course, 2002, Completed

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Degree 【 display / non-display 】

  • M.D. (Patholgy), Tokyo Medical and Dental University

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Campus Career 【 display / non-display 】

  • 2012.01
    -
    2015.03
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Systemic Organ Regulation， Human Pathology， Junior Associate Professor
  • 2023.05
    -
    Now
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Medical and Dental Sciences， Division of Systemic Organ Regulation， Department of Human Pathology， Visiting Lecturer
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Academic Society Affiliations 【 display / non-display 】

  • The Japanese Society of Pathology

  • The Japan Esophageal Society

  • Japanese Cancer Association

  • Japanese Gastric Cancer Association

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Research Areas 【 display / non-display 】

  • Human pathology

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Research Theme 【 display / non-display 】

  • Pathological analysis of the early colorectal cancer, 2004

  • Pathogenesis of esophageal squamous cell carcinoma

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Published Papers & Misc 【 display / non-display 】

  1. Nomura Fuminori, Sugimoto Taro, Kitagaki Keisuke, Ito Takashi, Kawachi Hiroshi, Eishi Yoshinobu, Watanabe Ken, Igaue Miki, Shimizu Norio, Tomita Makoto, Kitamura Ken, Kishimoto Seiji. Clinical characteristics of Japanese oropharyngeal squamous cell carcinoma positive for human papillomavirus infection. Acta Otolaryngol. 2014.12; 134 (12): 1265-1274. ( PubMed, DOI )

  2. Ueno Hideki, Shirouzu Kazuo, Shimazaki Hideyuki, Kawachi Hiroshi, Eishi Yoshinobu, Ajioka Yoichi, Okuno Kiyotaka, Yamada Kazutaka, Sato Toshihiko, Kusumi Takaya, Kushima Ryoji, Ikegami Masahiro, Kojima Motohiro, Ochiai Atsushi, Murata Akihiko, Akagi Yoshito, Nakamura Takahiro, Sugihara Kenichi, Study Group for Perineural Invasion projected by the Japanese Society for Cancer of the Colon and Rectum (JSCCR). Histogenesis and prognostic value of myenteric spread in colorectal cancer: a Japanese multi-institutional study. J Gastroenterol. 2014.03; 49 (3): 400-407. ( PubMed, DOI )

  3. Takemura Kosuke, Kawachi Hiroshi, Eishi Yoshinobu, Kitagaki Keisuke, Negi Mariko, Kobayashi Maki, Uchida Keisuke, Inoue Jun, Inazawa Johji, Kawano Tatsuyuki, Board Philip G. gamma-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors. Hum Pathol. 2014.02; 45 (2): 331-341. ( PubMed, DOI )

  4. Bae Yuan, Ito Takashi, Iida Tadatsune, Uchida Keisuke, Sekine Masaki, Nakajima Yutaka, Kumagai Jiro, Yokoyama Tetsuji, Kawachi Hiroshi, Akashi Takumi, Eishi Yoshinobu. Intracellular Propionibacterium acnes infection in glandular epithelium and stromal macrophages of the prostate with or without cancer. PLoS One. 2014; 9 (2): e90324. ( PubMed, DOI )

  5. Okamoto N, Kawachi H, Yoshida T, Kitagaki K, Sekine M, Kojima K, Kawano T, Eishi Y. "Crawling-type" adenocarcinoma of the stomach: a distinct entity preceding poorly differentiated adenocarcinoma. Gastric Cancer. 2013; 16 (2): 220-232. ( PubMed, DOI )

  6. Oda G, Sato T, Ishikawa T, Kawachi H, Nakagawa T, Kuwayama T, Ishiguro M, Iida S, Uetake H, Sugihara K. Significance of stromal decorin expression during the progression of breast cancer. Oncol Rep. 2012.12; 28 (6): 2003-2008. ( PubMed, DOI )

  7. Fujita K, Naganuma M, Saito E, Suzuki S, Araki A, Negi M, Kawachi H, Watanabe M. Histologically confirmed IgG4-related small intestinal lesions diagnosed via double balloon enteroscopy. Dig Dis Sci. 2012.12; 57 (12): 3303-3306. ( PubMed, DOI )

  8. Negi M, Takemura T, Guzman J, Uchida K, Furukawa A, Suzuki Y, Iida T, Ishige I, Minami J, Yamada T, Kawachi H, Costabel U, Eishi Y. Localization of propionibacterium acnes in granulomas supports a possible etiologic link between sarcoidosis and the bacterium. Mod Pathol. 2012.09; 25 (9): 1284-1297. ( PubMed, DOI )

  9. Miyawaki Y, Kawachi H, Ooi A, Eishi Y, Kawano T, Inazawa J, Imoto I. Genomic copy-number alterations of MYC and FHIT genes are associated with survival in esophageal squamous-cell carcinoma. Cancer Sci. 2012.08; 103 (8): 1558-1566. ( PubMed, DOI )

  10. Sakamoto K, Fujii T, Kawachi H, Miki Y, Omura K, Morita K, Kayamori K, Katsube K, Yamaguchi A. Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Lab Invest. 2012.05; 92 (5): 688-702. ( PubMed, DOI )

  11. Ueno H, Mochizuki H, Shirouzu K, Kusumi T, Yamada K, Ikegami M, Kawachi H, Kameoka S, Ohkura Y, Masaki T, Kushima R, Takahashi K, Ajioka Y, Hase K, Ochiai A, Wada R, Iwaya K, Nakamura T, Sugihara K,. Multicenter Study for Optimal Categorization of Extramural Tumor Deposits for Colorectal Cancer Staging. Annals of surgery. 2012.04; 255 (4): 739-746. ( PubMed, DOI )

  12. Nakajima Y, Ohta S, Okada T, Miyawaki Y, Hoshino A, Suzuki T, Kawada K, Nishikage T, Nagai K, Ae K, Kawachi H, Kawano T. Osteoplastic bone metastasis in esophageal squamous cell cancer: report of a case. Surg Today. 2012.04; 42 (4): 376-381. ( PubMed, DOI )

  13. Amano T, Eishi Y, Yamada T, Uchida K, Minegishi K, Tamura T, Kobayashi D, Kawachi H, Suzuki T, Board PG. Widespread Expression of γ-Glutamyl Cyclotransferase Suggests It Is Not a General Tumor Marker. J Histochem Cytochem. 2012.01; 60 (1): 76-86. ( PubMed, DOI )

  14. Takashima M, Kawachi H, Yamaguchi T, Nakajima Y, Kitagaki K, Sekine M, Iida T, Takemura K, Kawano T, Eishi Y.. Reduced expression of cytokeratin 4 and 13 is a valuable marker for histologic grading of esophageal squamous intraepithelial neoplasia. J Med Dent Sci. 2012; 59 17-28.

  15. Sugimoto H, Nakagawa T, Sato T, Nagahara M, Ishiba T, Kasahara M, Kawachi H, Kubota K, Sugihara K. [A long-surviving case of HER2-positive breast cancer with brain metastasis treated by multidisciplinary therapy]. Gan To Kagaku Ryoho. 2012; 39 (12): 2071-2073. ( PubMed )

  16. Ueno H, Mochizuki H, Akagi Y, Kusumi T, Yamada K, Ikegami M, Kawachi H, Kameoka S, Ohkura Y, Masaki T, Kushima R, Takahashi K, Ajioka Y, Hase K, Ochiai A, Wada R, Iwaya K, Shimazaki H, Nakamura T, Sugihara K. Optimal Colorectal Cancer Staging Criteria in TNM Classification. J Clin Oncol. 2012; 30 (13): 1519-1526. ( PubMed, DOI )

  17. Ueno H, Mochizuki H, Shirouzu K, Kusumi T, Yamada K, Ikegami M, Kawachi H, Kameoka S, Ohkura Y, Masaki T, Kushima R, Takahashi K, Ajioka Y, Hase K, Ochiai A, Wada R, Iwaya K, Nakamura T, Sugihara K. Actual status of distribution and prognostic impact of extramural discontinuous cancer spread in colorectal cancer. J Clin Oncol. 2011.06; 29 (18): 2550-2556. ( PubMed, DOI )

  18. Kawachi H. Histological evaluation of vascular permeation in colorectal carcinoma. Nippon Rinsho. 2011.04; 69 Suppl 3 340-345. ( PubMed )

  19. Sakamoto K, Aragaki T, Morita KI, Kawachi H, Kayamori K, Nakanishi S, Omura K, Miki Y, Okada N, Katsube KI, Takizawa T, Yamaguchi A. Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: a clue for histopathogenesis. Histopathology. 2011.03; 58 (4): 531-542. ( PubMed, DOI )

  20. Shimoyama T, Kimura B, Nakamura K, Yamada T, Kawachi H. Langerhans cell histiocytosis of the rib in adult male. Kyobu Geka. 2011.02; 64 (2): 135-138. ( PubMed )

  21. Kuramochi J, Inase N, Miyazaki Y, Kawachi H, Takemura T, Yoshizawa Y. Lung cancer in chronic hypersensitivity pneumonitis. Respiration. 2011; 82 (3): 263-267. ( PubMed, DOI )

  22. Kawachi H. Progress of pathologic research in esophageal cancer. Nippon Rinsho. 2011; 69 Suppl 6 79-84. ( PubMed )

  23. Oda G, Nakagawa T, Sato T, Kuwayama T, Yamamoto K, Kawachi H, Kubota K, Sugihara K. [A case of stage IV breast cancer with bone metastases that responded well for long-term to hormonal therapy]. Gan To Kagaku Ryoho. 2010.11; 37 (12): 2753-2755. ( PubMed )

  24. Sato T, Nakagawa T, Kuwayama T, Oda G, Kuboto K, Machida Y, Kawachi H, Sugihara K. [Pilot study of radiofrequency ablation (RFA) therapy in patients with early breast cancer]. Gan To Kagaku Ryoho. 2010.11; 37 (12): 2750-2752. ( PubMed )

  25. Chiba T, Kawachi H, Kawano T, Kumagai J, Kitagaki K, Sekine M, Uchida K, Kobayashi M, Sugihara K, Eishi Y. Independent histological risk factors for lymph node metastasis of superficial esophageal squamous cell carcinoma; implication of claudin-5 immunohistochemistry for expanding the indications of endoscopic resection. Dis Esophagus. 2010.07; 23 (5): 398-407. ( PubMed, DOI )

  26. Haruki S, Imoto I, Kozaki K, Matsui T, Kawachi H, Komatsu S, Muramatsu T, Shimada Y, Kawano T, Inazawa J. Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma. Carcinogenesis. 2010.06; 31 (6): 1027-1036. ( PubMed, DOI )

  27. Kumagai Y, Kawada K, Yamazaki S, Iida M, Ochiai T, Momma K, Odajima H, Kawachi H, Nemoto T, Kawano T, Takubo K. Endocytoscopic observation of esophageal squamous cell carcinoma. Dig Endosc. 2010.01; 22 (1): 10-16. ( PubMed, DOI )

  28. Matsuda A, Takahashi K, Yamaguchi T, Matsumoto H, Miyamoto H, Kawakami M, Kawachi H, Suzuki H, Furukawa K, Tajiri T, Mori T. HPV infection in an HIV-positive patient with primary squamous cell carcinoma of rectum. Int J Clin Oncol. 2009.12; 14 (6): 551-554. ( PubMed, DOI )

  29. Seki T, Ito T, Kawachi H, Sekine M, Funata N, Takizawa T. Relationship between mucin expression of gastric intramucosal signet ring cell carcinoma and its background mucosa. J Med Dent Sci. 2009.03; 56 (1): 25-35. ( PubMed )

  30. Fujishiro M, Oda I, Yamamoto Y, Akiyama J, Ishii N, Kakushima N, Fujiwara J, Morishita S, Kawachi H, Taniguchi H, Gotoda T. Multi-center survey regarding the management of anticoagulation and antiplatelet therapy for endoscopic procedures in Japan. J Gastroenterol Hepatol. 2009.02; 24 (2): 214-218. ( PubMed, DOI )

  31. Kumagai Y, Kawada K, Yamazaki S, Iida M, Momma K, Odajima H, Kawachi H, Nemoto T, Kawano T, Takubo K. Endocytoscopic observation for esophageal squamous cell carcinoma: can biopsy histology be omitted? Dis Esophagus. 2009; 22 (6): 505-512. ( PubMed, DOI )

  32. Kawano T, Haruki S, Ogiya K, Kawada K, Nakajima Y, Nishikage T, Kojima K, Nagai K, Kawachi H. Reliability of endoscopic esophageal mucosectomy using TxHood, a multipurpose treatment hood. Surg Endosc. 2008.11; 22 (11): 2466-2469. ( PubMed, DOI )

  33. Ochiai T, Saito Y, Saitoh T, Dewan MZ, Shioya A, Kobayashi M, Kawachi H, Muto S, Itai A, Uota S, Eishi Y, Yamamoto N, Tanaka S, Arii S, Yamaoka S. Inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells. J Med Dent Sci. 2008.03; 55 (1): 49-59. ( PubMed )

  34. Nakagawa T, Iida S, Osanai T, Uetake H, Aruga T, Toriya Y, Takagi Y, Kawachi H, Sugihara K. Decreased expression of SOCS-3 mRNA in breast cancer with lymph node metastasis. Oncol Rep. 2008.01; 19 (1): 33-39. ( PubMed )

  35. Sasajima K, Kudo SE, Inoue H, Takeuchi T, Kashida H, Hidaka E, Kawachi H, Sakashita M, Tanaka J, Shiokawa A. Real-time in vivo virtual histology of colorectal lesions when using the endocytoscopy system. Gastrointest Endosc. 2006.06; 63 (7): 1010-1017. ( PubMed, DOI )

  36. Kobayashi M, Kawachi H, Takizawa T, Uchida K, Sekine M, Kumagai J, Momma K, Nemoto T, Akashi T, Funata N, Eishi Y, Koike M. p53 Mutation analysis of low-grade dysplasia and high-grade dysplasia/carcinoma in situ of the esophagus using laser capture microdissection. Oncology. 2006; 71 (3-4): 237-245. ( PubMed, DOI )

  37. Yoshida T, Kawachi H, Sasajima K, Shiokawa A, Kudo SE. The clinical meaning of a nonstructural pattern in early gastric cancer on magnifying endoscopy. Gastrointest Endosc. 2005.07; 62 (1): 48-54. ( PubMed )

  38. Hasegawa S, Kawachi H, Kurosawa H, Obi Y, Yamanaka K, Nakamura K, Abe T. Malignant fibrous histiocytoma in the ileum associated with intussusception. Dig Dis Sci. 2004.08; 49 (7-8): 1156-1160. ( PubMed )

  39. Tanabe H, Akashi T, Kawachi H, Andou N, Eishi Y, Takizawa T, Koike M, Ichinose S. Identification of hydroxyapatite deposits in the smooth muscle cells and ganglion cells of autopsied small intestines. J Med Dent Sci. 2004.06; 51 (2): 129-138. ( PubMed )

  40. Hidaka E, Kawachi H, Sakashita M, Kudo SE. [Pathological diagnosis and problems in colorectal cancer] Nippon Rinsho. 2003.09; 61 Suppl 7 135-138. ( PubMed )

  41. Kawachi H, Takizawa T, Eishi Y, Shimizu S, Kumagai J, Funata N, Koike M. Absence of either gastric or intestinal phenotype in microscopic differentiated gastric carcinomas. J Pathol. 2003.04; 199 (4): 436-446. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display 】

  1. Hallazgos de anatomia patologica de un programma de deteccion de lesiones neoplasicas colorrectales. XL Congreso Chileno de Gastroenterologia (Pucon, Chile) 2013

  2. Papillary adenocarcinoma of the stomach, its clinicopathological significance. 80th Annual Meeting of the Japanese Cancer Association (Yokohama, Japan), Japan and Korea Joint Session 3; pathology 2008

  3. Histological evaluation of "tumor budding/sprouting" as predictive factor of lymph nodes metastasis in submucosal invasive colorectal cancer. The 10th Korea-Japan-China Colorectal Cancer Symposium (16th September 2006, Seoul, Korea) 2006

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