Personnel Information

写真a

NISHIMURA Emi


Job title

Professor

Birth date

1968

Mail Address

nishscm@tmd.ac.jp

Graduating School 【 display / non-display

  • Shiga University of Medical Science, Faculty of Medicine, 1994, Graduated

Graduate School 【 display / non-display

  • Kyoto University, Graduate School, Division of Medicine, Doctor's Course, 2000, Completed

Degree 【 display / non-display

  • M.D., Ph.D., Kyoto University

Campus Career 【 display / non-display

  • 2009.03
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Stem Cell Biology, Professor
  • 2009.03
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Systemic Organ Regulation, Stem Cell Biology, Professor

Academic Society Affiliations 【 display / non-display

  • Japanese Society for Pigment Cell Research

  • International Society for Stem Cell Research

  • International Federation of Pigment Cell Society

  • The Molecular Biology Society of Japan

  • The Japanese Society of Inflammation and Regeneration

  • Japanese Cancer Association

  • Japanese Dermatological Association

  • The Japanese Society for Investigative Dermatology

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Published Papers & Misc 【 display / non-display

  1. Kinoshita K, Munesue T, Toki F, Higashiyama S, Barrandon Y, Nishimura EK, Yanagihara Y, Nanba D. Automated collective motion analysis validates human keratinocyte stem cell cultures. Scientific Reports. 2019.12; 9 (1): ( PubMed, DOI )

  2. Muraguchi T, Nanba D, Nishimura EK., Tashiro T. IGF-1R deficiency in human keratinocytes disrupts epidermal homeostasis and stem cell maintenance Journal of Dermatological Science. 2019.05; 94 (2): 298-305. ( PubMed, DOI )

  3. Liu N, Matsumura H, Nishimura EK. et al.. Stem cell competition orchestrates skin homeostasis and ageing Nature. 2019.04; 568 (7752): 344-350. ( PubMed, DOI )

  4. Noguchi S, Honda S, Saitoh T, Matsumura H, Nishimura EK, Akira S, Shimizu S. Beclin 1 regulates recycling endosome and is required for skin development in mice. Communications Biology. 2019.01; 2 (37): ( PubMed, DOI )

  5. Sasaki M, Shinozaki S, Morinaga H, Kaneki M, Nishimura EK, Shimokado K. iNOS inhibits hair regeneration in obese diabetic (ob/ob) mice. Biochemical and Biophysical Research Communications. 2018.07; 501 (4): 893-897. ( PubMed, DOI )

  6. Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakaki M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T, and Takubo K. P38 α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress Cell Stem Cell. 2016.08; 19 (2): 192-204. ( DOI )

  7. Hiroyuki Matsumura,* Yasuaki Mohri,* Nguyen Thanh Binh,* Hironobu Morinaga, Makoto Fukuda, Mayumi Ito, Sotaro Kurata, Jan Hoeijmakers, Emi K. Nishimura. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis Science. 2016.02; 351 (6273): 575-589. ( PubMed, DOI )

  8. Sota Tate, Matome Imai, Natsuki Matsushita, Emi K. Nishimura, Shigeki Higashiyama, Daisuke Nanba. Rotation is the primary motion of paired human epidermal keratinocytes Jounal of Dermatological Science. 2015.09; 79 (3): 194-202. ( PubMed, DOI )

  9. Makiko Ueno, Takahiro Aoto, Yasuaki Mohri, Hiroo Yokozeki, Emi K Nishimura. Coupling of the radiosensitivity of melanocyte stem cells to their dormancy during the hair cycle. Pigment Cell Melanoma Res. 2014.07; 27 (4): 540-551. ( PubMed, DOI )

  10. Natsuko Okamoto, Takahiro Aoto, Hisashi Uhara, Satoshi Yamazaki, Hidenori Akutsu, Akihiro Umezawa, Hiromitsu Nakauchi, Yoshiki Miyachi, Toshiaki Saida, Emi K Nishimura. A melanocyte-melanoma precursor niche in sweat glands of volar skin. Pigment Cell Melanoma Res. 2014.07; 27 (6): 1039-1050. ( PubMed, DOI )

  11. Emi K Nishimura. Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation. Pigment Cell Melanoma Res. 2011.06; 24 (3): 401-410. ( PubMed, DOI )

  12. Shintaro Tanimura, Yuko Tadokoro, Ken Inomata, Nguyen Thanh Binh, Wataru Nishie, Satoshi Yamazaki, Hiromitsu Nakauchi, Yoshio Tanaka, James R McMillan, Daisuke Sawamura, Kim Yancey, Hiroshi Shimizu, Emi K Nishimura. Hair follicle stem cells provide a functional niche for melanocyte stem cells. Cell Stem Cell. 2011.02; 8 (2): 177-187. ( PubMed, DOI )

  13. Nishimura EK, Suzuki M, Igras V, Du J, Lonning S, Miyachi Y, Roes J, Beermann F, Fisher DE. Key roles for transforming growth factor Beta in melanocyte stem cell maintenance. Cell Stem Cell. 2010.02; 6 (2): 130-140. ( PubMed, DOI )

  14. Miura M, Ueda A, Takao Y, Nishimura EK, Koide H, Yokota T. A stem cell-derived gene (Sddr) negatively regulates differentiation of embryonic stem cells. Int J Dev Biol. 2010; 54 (1): 33-39. ( PubMed, DOI )

  15. Inomata K, Aoto T, Binh NT, Okamoto N, Tanimura S, Wakayama T, Iseki S, Hara E, Masunaga T, Shimizu H, Nishimura EK. Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation Cell. 2009; 137 (6): 1088-1099. ( PubMed, DOI )

  16. Sato-Jin K, Nishimura EK, Akasaka E, Huber W, Nakano H, Miller A, Du J, Wu M, Hanada K, Sawamura D, Fisher DE, Imokawa G. Epistatic connections between microphthalmia-associated transcription factor and endothelin signaling in Waardenburg syndrome and other pigmentary disorders FASEB J. 2008; 22 (4): 1155-1168. ( PubMed, DOI )

  17. Yang G, Li Y, Nishimura EK, Xin H, Zhou A, Guo Y, Dong L, Denning MF, Nickoloff BJ, Cui R. Inhibition of PAX3 by TGF-beta modulates melanocyte viability Mol Cell. 2008; 32 (4): 554-563. ( PubMed, DOI )

  18. D'Orazio JA, Nobuhisa T, Cui R, Arya M, Spry M, Wakamatsu K, Igras V, Kunisada T, Granter SR, Nishimura EK, Ito S, Fisher DE. Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning Nature. 2006; 443 (7109): 340-344. ( PubMed, DOI )

  19. McGill GG, Haq R, Nishimura EK, Fisher DE. c-Met expression is regulated by Mitf in the melanocyte lineage J Biol Chem. 2006; 281 (15): 10365-10373. ( PubMed, DOI )

  20. Nishimura EK, Granter SR, Fisher DE. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche Science. 2005; 307 (5710): 720-724. ( PubMed, DOI )

  21. Osawa M, Nishimura EK. [Stem cells in the mammalian hair follicle] Tanpakushitsu Kakusan Koso. 2004; 49 (6): 727-733. ( PubMed )

  22. Du J, Widlund HR, Horstmann MA, Ramaswamy S, Ross K, Huber WE, Nishimura EK, Golub TR, Fisher DE. Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF Cancer Cell. 2004; 6 (6): 565-576. ( PubMed, DOI )

  23. Nishimura EK, Jordan SA, Oshima H, Yoshida H, Osawa M, Moriyama M, Jackson IJ, Barrandon Y, Miyachi Y, Nishikawa S. Dominant role of the niche in melanocyte stem-cell fate determination Nature. 2002; 416 (6883): 854-860. ( PubMed, DOI )

  24. McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, Nishimura EK, Lin YL, Ramaswamy S, Avery W, Ding HF, Jordan SA, Jackson IJ, Korsmeyer SJ, Golub TR, Fisher DE. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability Cell. 2002; 109 (6): 707-718. ( PubMed )

  25. H Yoshida, T Kunisada, T Grimm, E K Nishimura, E Nishioka, S I Nishikawa. Review: melanocyte migration and survival controlled by SCF/c-kit expression. J. Investig. Dermatol. Symp. Proc.. 2001.11; 6 (1): 1-5. ( PubMed, DOI )

  26. E K Nishimura, H Yoshida, T Kunisada, S I Nishikawa. Regulation of E- and P-cadherin expression correlated with melanocyte migration and diversification. Dev. Biol.. 1999.11; 215 (2): 155-166. ( PubMed, DOI )

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Conference Activities & Talks 【 display / non-display

  1. 西村 栄美. Stem cell-Centric strategies for organ regeneration and aging. RIKEN aging project symposium 2020 2020.01.20

  2. Emi K. Nishimura. Stem cell competition underlies skin homeostasis and aging. 日本研究皮膚科学会第44回年次学術大会 2019.11.08 青森県

  3. Emi K. Nishimura. Stem cell fate changes in skin organ aging. Fondation des treilles Stem Cells, Aging and stress response mechanisms 2019.10.07 France

  4. Emi K. Nishimura. Stem cell competition in skin homeostasis and aging. Gordon research conference-epithelial differentiation and keratinization 2019.07.07 USA

  5. Emi K. Nishimura. Stem cell competition orchestrates skin homeostasis and ageing. Nature conference 2019-aging, health & rejuvenation 2019.06.23 Netherlands

  6. 西村 栄美. Stem cell competition orchestrates skin homeostasis and ageing. 第17回幹細胞シンポジウム 2019.05.24 兵庫県

  7. Emi K. Nishimura. Stem cell competition underlies skin homeostasis and aging. Japan-singapore international skin conference 2019 2019.04.10 Singapore

  8. Emi K. Nishimura. Epidermal stem cell competition coupled with stem cell divisions in mammalian epidermis. 2019 Keystone Symposia Conference-Cell Competition in Development and Disease- 2019.02.24 Tahoe City, USA

  9. 西村 栄美. Cell fate determination in aging organs:stem cell aging vs cellular senescence. 第41回日本分子生物学会年会 2018.11.29 パシフィコ横浜

  10. 西村 栄美. 毛包をモデルとした器官の再生と老化. NCGMRI Science Forum 2018.10.03 東京

  11. Emi K. Nishimura. Stem cell and niche dynamics in aging skin. Gordon Research Conferences-Issue niches and resident stem cells in adult epithelia- 2018.08.19 New Hampshire, USA

  12. Emi K. Nishimura. Melanocyte stem cells and melanoma. Montagna Symposium on the Biology of Skin 2018.08.19

  13. Emi K. Nishimura. Stem cell-centricmechanisms of hair follicle aging. Gordon Research Conference-Cornea and Ocular Surface Biology and Pathology- 2018.02.18 California, USA

  14. Emi K. Nishimura. Stem cells orchestrates hair follicle aging program. International Meeting on RECQ Helicases and Related Disease 2018 2018.02.16 Chiba, Japan

  15. Emi K. Nishimura. Stem cells orchestrates hair follicle aging program. JSPS&NUS Joint 2nd Symposium"New Horizons in Normal and Cancer Stem Cell Research" 2018.01.18 Kumamoto, Japan

  16. Emi K. Nishimura. Stem cells orchestrates hair follicle aging program. Stem Cell in Disease Modeling and Therapeutics 2017.11.13 Tokyo, Japan

  17. Emi K. Nishimura. The mechanism of aging-associated hair graying and hair thinning:toward the discovery of pharmacological targets. WCHR2017(10th World Congress for Hair Research) 2017.11.03 Kyoto, Japan

  18. Emi K. Nishimura. Stem cells orchestrates hair follicle aging program. WCHR2017(10th World Congress for Hair Research) 2017.11.03 Kyoto, Japan

  19. Emi K. Nishimura. Stem cells orchestrates hair follicle aging program. WCHR2017(10th World Congress for Hair Research) 2017.10.01 Kyoto, Japan

  20. Emi K. Nishimura. Melanocyte stem cells in eccrine sweat glands: a potential original of acral melanoma. IPCC2017 2017.08.26 Denver, USA

  21. Emi K. Nishimura. Stem cells orchestrates hair follicle aging program. International Society for Stem Cell Researech 2017 Annual Meeting 2017.06.14 Boston, USA

  22. Emi K. Nishimura. Tissue aging program based on stem cell aging in hair follicle. KEYSTONE SYMPOSIA on Moleular and Cellular Biology -Aging and Mechanisms of Aging-Related Disease- 2017.05.15 Pacifico YOKOHAMA, Kanagawa, Japan

  23. 西村 栄美. Stem cell aging: the core to orchestrates tissue aging. Aging Science:from Molecules to Society-Aging Biology- 2017.05.09 Tohoku University

  24. Emi Nishimura. Melanocyte Stem Cells in eccrine seat glands: a potential of acral melanoma. 12th Meeting od the German-Japanese Society of Dermatology 2016.10.13 Nagano, Japan

  25. Emi Nishimura. New Insights in Stem Cell Research & Age-related Changes in Skin and Hair Pigmentation. 46th Annual ESDR Meeting 2016.09 Munich, Germany

  26. Emi Nishimura. Mechanisms of hair follicle aging and hair loss. Cell Symposia: Aging and Metabolism 2016 2016.07.10 Melia Sitges, Spain

  27. Emi Nishimura. stem cell aging: a clue to understand hair thinning and graying. 1st International Symposium on Stem Cell Aging and Disease 2016.06.29 Tokyo, Japan

  28. Emi K. Nishimura. Hair follicle aging program in hair follicle stem cells orchestrates dynamic tissue aging and associated hair loss. Gordon Research Conferences-Epithelial Differentiation & keratinization 2015.07.12 Boston, USA

  29. Emi K. Nishimura. Stem cells in skin appendages and their fate change by aging. 23rd World Congress of Dermatology 2015.06.08 Vancouver, Canada

  30. Emi K. Nishimura. Melanocyte Stem Cells: a Key for Hair Graying and Melanoma. The 25th Annual Meeting of Korean Society for Investigative Dermatology 2015.03.27 Seoul, Korea

  31. Emi K. Nishimura. Identification of melanocyte stem cells and melanocyte-melanoma precursor niche in sweat glands. International Symposium on Tumor Biology in Kanazawa 2014.11.04 Kanazawa

  32. Emi K. Nishimura. Coupling of the Stress Sensitivity of Melanocyte Stem Cells to their Dormancy during a Hair Cycle. IPCC 2014 2014.09.07 Singapore

  33. Emi K. Nishimura. Stress Sensitivity of Melanocyte Stem Cells during a Hair Cycle. 8th World Congress for Hair Research 2014.05.14 Jeju Island, Korea

  34. Emi K. Nishimura. Hair Follicle Aging and Stem Cell Regulation. 8th World Congress for Hair Research 2014.05.14 Jeju Island, Korea

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Patents 【 display / non-display

  • COMPOSITION FOR PREVENTING OR AMELIORATING LOSS OF HAIR AND GRAYING OF HAIR, AND USE THEREOF

    Patent Number: US10702544

Awards & Honors 【 display / non-display

  • Myron Gordon Award,International federation of Pigment Cell Societies(IFPCS),2017.08

  • The 2013 Research Achievement Award,American Skin Association,2013.05

  • Shiseido Award,2002.08