論文・総説 - 樗木　俊聡

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  1. Miwako Sase, Taku Sato, Hajime Sato, Fuyuki Miya, Shicheng Zhang, Hiroshi Haeno, Mihoko Kajita, Tadahide Noguchi, Yoshiyuki Mori, Toshiaki Ohteki. Comparative analysis of tongue cancer organoids among patients identifies the heritable nature of minimal residual disease. Dev Cell. 2025.02; 60 (3): 396-413.e6. ( PubMed, DOI )

  2. Akiyama M, Kanayama M, Umezawa Y, Nagao T, Izumi Y, Yamamoto M, Ohteki T.. An early regulatory mechanism of hyperinflammation by restricting monocyte contribution Front Immunol.. 2024.07; 15 1398153.

  3. Ohara D, Takeuchi Y, Watanabe H, Lee Y, Mukoyama H, Ohteki T, Kondoh G, Hirota K.. Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM+ DCIR2+ cDC2s in mice J Exp Med.. 2024.02; 221 e20230923.

  4. Kamii Y, Hayashizaki K, Kanno T, Chiba A, Ikegami T, Saito M, Akeda Y, Ohteki T, Kubo M, Yoshida K, Kawakami K, Oishi K, Araya J, Kuwano K, Kronenberg M, Endo Y, Kinjo Y.. IL-27 regulates the differentiation of follicular helper NKT cells via metabolic adaptation of mitochondria. Proc Natl Acad Sci USA.. 2024.02; 121 e2313964121.

  5. Shinya Abe, Takuma Asahi, Takahiro Hara, Guangwei Cui, Akihiro Shimba, Shizue Tani-Ichi, Kohei Yamada, Kazuko Miyazaki, Hitoshi Miyachi, Satsuki Kitano, Naotoshi Nakamura, Junichi Kikuta, Alexis Vandenbon, Masaki Miyazaki, Ryo Yamada, Toshiaki Ohteki, Masaru Ishii, Veronika Sexl, Takashi Nagasawa, Koichi Ikuta. Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow. Cell Rep. 2023.09; 42 (9): 113127. ( PubMed, DOI )

  6. Ziegler-Heitbrock L, Ohteki T, Ginhoux F, Shortman K, Spits H.. Reply to 'Reclassifying plasmacytoid dendritic cells as innate lymphocytes is premature'. Nat Rev Immunol. 2023.05; 23 (5): 338-339.

  7. Masashi Kanayama, Yuta Izumi, Megumi Akiyama, Toyoki Hayashi, Koji Atarashi, Axel Roers, Taku Sato, Toshiaki Ohteki. Myeloid-like B cells boost emergency myelopoiesis through IL-10 production during infection. J Exp Med. 2023.04; 220 (4): e20221221. ( PubMed, DOI )

  8. Loems Ziegler-Heitbrock, Toshiaki Ohteki, Florent Ginhoux, Ken Shortman, Hergen Spits. Reclassifying plasmacytoid dendritic cells as innate lymphocytes. Nat Rev Immunol. 2022.10; 23 (1): 1-2. ( PubMed, DOI )

  9. Guangwei Cui, Akihiro Shimba, Jianshi Jin, Taisaku Ogawa, Yukiko Muramoto, Hitoshi Miyachi, Shinya Abe, Takuma Asahi, Shizue Tani-Ichi, Johannes M Dijkstra, Yayoi Iwamoto, Kirill Kryukov, Yuanbo Zhu, Daichi Takami, Takahiro Hara, Satsuki Kitano, Yan Xu, Hajime Morita, Moyu Zhang, Lynn Zreka, Keishi Miyata, Takashi Kanaya, Shinya Okumura, Takashi Ito, Etsuro Hatano, Yoshimasa Takahashi, Hiroshi Watarai, Yuichi Oike, Tadashi Imanishi, Hiroshi Ohno, Toshiaki Ohteki, Nagahiro Minato, Masato Kubo, Georg A Holländer, Hideki Ueno, Takeshi Noda, Katsuyuki Shiroguchi, Koichi Ikuta. A circulating subset of iNKT cells mediates antitumor and antiviral immunity. Sci Immunol. 2022.10; 7 (76): eabj8760. ( PubMed, DOI )

  10. Adachi A, Honda T, Dainichi T, Egawa G, Yamamoto Y, Nomura T, Nakajima S, Otsuka A, Maekawa M, Mano N, Koyanagi N, Kawaguchi Y, Ohteki T, Nagasawa T, Ikuta K, Kitoh A, Kabashima K.. Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids. J Allergy Clin Immunol. 2021.12;

  11. Ohteki T, Kawamura S, Onai N.. Commitment to dendritic cells and monocytes. Int Immunol.. 2021.11;

  12. Izumi Y, Kanayama M, Shen Z, Kai M, Kawamura S, Akiyama M, Yamamoto M, Nagao T, Okada K, Kawamata N, Toyota S, Ohteki T.. An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer Therapy. Front Immunol.. 2021.02; 12 618081..

  13. Kana Minamide, Taku Sato, Yusuke Nakanishi, Hiroshi Ohno, Tamotsu Kato, Jumpei Asano, Toshiaki Ohteki. IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon. Sci Rep. 2020.09; 10 (1): 14639. ( PubMed, DOI )

  14. Kanayama M, Izumi Y, Yamauchi Y, Kuroda S, Shin T, Ishikawa S, Sato T, Kajita M, Ohteki T.. CD86-based analysis enables observation of bona fide hematopoietic responses Blood.. 2020.09; 136 (10): 1144-1154.

  15. Sato T, Ishikawa S, Asano J, Yamamoto H, Fujii M, Sato T, Yamamoto K, Kitagaki K, Akashi T, Okamoto R, Ohteki T.. Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages. Nat Cell Biol. . 2020.08; 22 (8): 919-926.

  16. Taku Sato, Miwako Sase, Shun Ishikawa, Mihoko Kajita, Jumpei Asano, Toshiro Sato, Yoshiyuki Mori, Toshiaki Ohteki. Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine. Sci Rep. 2020.05; 10 (1): 8308. ( PubMed, DOI )

  17. Jumpei Asano, Taku Sato, Toshiaki Ohteki. Autophagy Detection in Intestinal Stem Cells. Methods Mol Biol. 2020; 2171 115-125. ( PubMed, DOI )

  18. Hiroyuki Tezuka, Toshiaki Ohteki. Regulation of IgA Production by Intestinal Dendritic Cells and Related Cells. Front Immunol. 2019.08; 10 1891. ( PubMed, DOI )

  19. Takahiro Adachi, Soichiro Yoshikawa, Hiroyuki Tezuka, Noriko M Tsuji, Toshiaki Ohteki, Hajime Karasuyama, Toshihiko Kumazawa. Propolis induces Ca2+ signaling in immune cells. Bioscience of microbiota, food and health. 2019.08; 38 (4): 141-149. ( PubMed, DOI )

  20. Zi Wang, Soichiro Adachi, Lingling Kong, Daisuke Watanabe, Yusuke Nakanishi, Toshiaki Ohteki, Namiko Hoshi, Yuzo Kodama. Role of eosinophils in a murine model of inflammatory bowel disease. Biochem. Biophys. Res. Commun.. 2019.03; 511 (1): 99-104. ( PubMed, DOI )

  21. Shunsuke Kawamura, Toshiaki Ohteki. Monopoiesis in humans and mice. Int. Immunol.. 2018.10; 30 (11): 503-509. ( PubMed, DOI )

  22. Y Nakanishi, T Sato, K Takahashi, T Ohteki. IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte/macrophage lineage differentiation in vivo. Mucosal Immunol. 2018.05; 11 (3): 871-880. ( PubMed, DOI )

  23. Nobuyuki Onai, Jumpei Asano, Rumiko Kurosaki, Shoko Kuroda, Toshiaki Ohteki. Flexible fate commitment of E2-2high common DC progenitors implies tuning in tissue microenvironments. Int. Immunol.. 2017.12; 29 (10): 443-456. ( PubMed, DOI )

  24. Kenshiro Matsuda, Noriko Okamoto, Masatoshi Kondo, Peter D Arkwright, Kaoru Karasawa, Saori Ishizaka, Shinichi Yokota, Akira Matsuda, Kyungsook Jung, Kumiko Oida, Yosuke Amagai, Hyosun Jang, Eiichiro Noda, Ryota Kakinuma, Koujirou Yasui, Uiko Kaku, Yasuo Mori, Nobuyuki Onai, Toshiaki Ohteki, Akane Tanaka, Hiroshi Matsuda. Mast cell hyperactivity underpins the development of oxygen-induced retinopathy. J. Clin. Invest.. 2017.11; 127 (11): 3987-4000. ( PubMed, DOI )

  25. Jumpei Asano, Taku Sato, Shizuko Ichinose, Mihoko Kajita, Nobuyuki Onai, Shigeomi Shimizu, Toshiaki Ohteki. Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration. Cell Rep. 2017.08; 20 (5): 1050-1060. ( PubMed, DOI )

  26. Niken Adiba Nadya, Hiroyuki Tezuka, Toshiaki Ohteki, Satoshi Matsuda, Miyuki Azuma, Shigenori Nagai. PI3K-Akt pathway enhances the differentiation of interleukin-27-induced type 1 regulatory T cells. Immunology. 2017.07; 152 (3): 507-516. ( PubMed, DOI )

  27. Shunsuke Kawamura, Nobuyuki Onai, Fuyuki Miya, Taku Sato, Tatsuhiko Tsunoda, Kazutaka Kurabayashi, Satoshi Yotsumoto, Shoko Kuroda, Katsuto Takenaka, Koichi Akashi, Toshiaki Ohteki. Identification of a Human Clonogenic Progenitor with Strict Monocyte Differentiation Potential: A Counterpart of Mouse cMoPs. Immunity. 2017.05; 46 (5): 835-848.e4. ( PubMed, DOI )

  28. Takayuki Yokoi, Kentarou Yokoi, Kazumasa Akiyama, Takashi Higuchi, Yohta Shimada, Hiroshi Kobayashi, Taku Sato, Toshiaki Ohteki, Makoto Otsu, Hiromitsu Nakauchi, Hiroyuki Ida, Toya Ohashi. Non-myeloablative preconditioning with ACK2 (anti-c-kit antibody) is efficient in bone marrow transplantation for murine models of mucopolysaccharidosis type II. Mol. Genet. Metab.. 2016.11; 119 (3): 232-238. ( PubMed, DOI )

  29. Jiajia Liu, Yong-Mei Guo, Nobuyuki Onai, Hideaki Ohyagi, Makoto Hirokawa, Naoto Takahashi, Hiroyuki Tagawa, Kumi Ubukawa, Isuzu Kobayashi, Hiroyuki Tezuka, Yoshihiro Minamiya, Toshiaki Ohteki, Kenichi Sawada. Cytosine-Phosphorothionate-Guanine Oligodeoxynucleotides Exacerbates Hemophagocytosis by Inducing Tumor Necrosis Factor-Alpha Production in Mice after Bone Marrow Transplantation. Biol Blood Marrow Transplant. 2016.04; 22 (4): 627-636. ( PubMed, DOI )

  30. Nobuyuki Onai, Toshiaki Ohteki. Isolation of Dendritic Cell Progenitor and Bone Marrow Progenitor Cells from Mouse. Methods Mol. Biol.. 2016.01; 1423 53-59. ( PubMed, DOI )

  31. Hiroshi Kobayashi, Chiharu I Kobayashi, Ayako Nakamura-Ishizu, Daiki Karigane, Hiroshi Haeno, Kimiyo N Yamamoto, Taku Sato, Toshiaki Ohteki, Yoshihiro Hayakawa, Glen N Barber, Mineo Kurokawa, Toshio Suda, Keiyo Takubo. Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING. Cell Rep. 2015.04; 11 (1): 71-84. ( PubMed, DOI )

  32. Y Nakanishi, T Sato, T Ohteki. Commensal Gram-positive bacteria initiates colitis by inducing monocyte/macrophage mobilization. Mucosal Immunol. 2015.01; 8 (1): 152-160. ( PubMed, DOI )

  33. Nobuyuki Onai, Toshiaki Ohteki. Bipotent or Oligopotent? A Macrophage and DC Progenitor Revisited. Immunity. 2014.07; 41 (1): 5-7. ( PubMed, DOI )

  34. A Yokota-Nakatsuma, H Takeuchi, Y Ohoka, C Kato, S-Y Song, T Hoshino, H Yagita, T Ohteki, M Iwata. Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells. Mucosal Immunol. 2014.07; 7 (4): 786-801. ( PubMed, DOI )

  35. Hideaki Ohyagi, Nobuyuki Onai, Taku Sato, Satoshi Yotsumoto, Jiajia Liu, Hisaya Akiba, Hideo Yagita, Koji Atarashi, Kenya Honda, Axel Roers, Werner Müller, Kazutaka Kurabayashi, Mayuka Hosoi-Amaike, Naoto Takahashi, Makoto Hirokawa, Kouji Matsushima, Kenichi Sawada, Toshiaki Ohteki. Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. Immunity. 2013.09; 39 (3): 584-598. ( PubMed, DOI )

  36. Takayuki Sato, Toshio Kitawaki, Haruyuki Fujita, Makoto Iwata, Tomonori Iyoda, Kayo Inaba, Toshiaki Ohteki, Suguru Hasegawa, Kenji Kawada, Yoshiharu Sakai, Hiroki Ikeuchi, Hiroshi Nakase, Akira Niwa, Akifumi Takaori-Kondo, Norimitsu Kadowaki. Human CD1c⁺ myeloid dendritic cells acquire a high level of retinoic acid-producing capacity in response to vitamin D₃. J Immunol. 2013.09; 191 (6): 3152-3160. ( PubMed, DOI )

  37. Atsushi Hayashi, Toshiro Sato, Nobuhiko Kamada, Yohei Mikami, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Toshifumi Hibi, Axel Roers, Hideo Yagita, Toshiaki Ohteki, Akihiko Yoshimura, Takanori Kanai. A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice. Cell Host Microbe. 2013.06; 13 (6): 711-722. ( PubMed, DOI )

  38. Nobuyuki Onai, Kazutaka Kurabayashi, Mayuka Hosoi-Amaike, Noriko Toyama-Sorimachi, Kouji Matsushima, Kayo Inaba, Toshiaki Ohteki. A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential. Immunity. 2013.05; 38 (5): 943-957. ( PubMed, DOI )

  39. Taku Sato, Mahoko Ikeda, Satoshi Yotsumoto, Yohta Shimada, Takashi Higuchi, Hiroshi Kobayashi, Takahiro Fukuda, Toya Ohashi, Toshio Suda, Toshiaki Ohteki. Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder. Blood. 2013.04; 121 (16): 3267-3273. ( PubMed, DOI )

  40. Akihiko Ichikawa, Keiji Kuba, Masayuki Morita, Shinsuke Chida, Hiroyuki Tezuka, Hiromitsu Hara, Takehiko Sasaki, Toshiaki Ohteki, V Marco Ranieri, Claudia C dos Santos, Yoshihiro Kawaoka, Shizuo Akira, Andrew D Luster, Bao Lu, Josef M Penninger, Stefan Uhlig, Arthur S Slutsky, Yumiko Imai. CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med. 2013.01; 187 (1): 65-77. ( PubMed, DOI )

  41. Jiajia Liu, Yong-Mei Guo, Makoto Hirokawa, Keiko Iwamoto, Kumi Ubukawa, Yoshihiro Michishita, Naohito Fujishima, Hiroyuki Tagawa, Naoto Takahashi, Weiguo Xiao, Junsuke Yamashita, Toshiaki Ohteki, Kenichi Sawada. A synthetic double-stranded RNA, poly I:C, induces a rapid apoptosis of human CD34(+) cells. Exp Hematol. 2012.04; 40 (4): 330-341. ( PubMed, DOI )

  42. Hirosato Mashima, Taku Sato, Yasuo Horie, Yuko Nakagawa, Itaru Kojima, Toshiaki Ohteki, Hirohide Ohnishi. Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells. Gastroenterology. 2011.09; 141 (3): 1102-1113.e1. ( PubMed, DOI )

  43. 樗木俊聡. 腸管粘膜における樹状細胞の役割(The Role of dendritic cells in the intestinal mucosa) 日本耳鼻咽喉科学会会報　114. 2011.06; 107-113.

  44. Hiroyuki Tezuka, Yukiko Abe, Jumpei Asano, Taku Sato, Jiajia Liu, Makoto Iwata, Toshiaki Ohteki. Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction. Immunity. 2011.02; 34 (2): 247-257. ( PubMed, DOI )

  45. Yoshitake Kanazawa, Yasuyuki Saito, Yana Supriatna, Hiroyuki Tezuka, Takenori Kotani, Yoji Murata, Hideki Okazawa, Hiroshi Ohnishi, Yoshitaka Kinouchi, Yoshihisa Nojima, Toshiaki Ohteki, Tooru Shimosegawa, Takashi Matozaki. Role of SIRPα in regulation of mucosal immunity in the intestine. Genes Cells. 2010.12; 15 (12): 1189-1200. ( PubMed, DOI )

  46. Hiroyuki Tezuka, Toshiaki Ohteki. A gas governing mucosal immunity. Vaccine. 2010.11; 28 (50): 8039-8040. ( PubMed, DOI )

  47. Yong-Mei Guo, Keiko Ishii, Makoto Hirokawa, Hiroyuki Tagawa, Hideaki Ohyagi, Yoshihiro Michishita, Kumi Ubukawa, Junsuke Yamashita, Toshiaki Ohteki, Nobuyuki Onai, Kazuyoshi Kawakami, Weiguo Xiao, Kenichi Sawada. CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells. Blood. 2010.06; 115 (22): 4569-4579. ( PubMed, DOI )

  48. Hiroyuki Tezuka, Toshiaki Ohteki. Regulation of intestinal homeostasis by dendritic cells. Immunol Rev. 2010.03; 234 (1): 247-258. ( PubMed, DOI )

  49. Jumpei Asano, Hiroyuki Tada, Nobuyuki Onai, Taku Sato, Yasuo Horie, Yukari Fujimoto, Koichi Fukase, Akira Suzuki, Tak W Mak, Toshiaki Ohteki. Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. J Immunol. 2010.01; 184 (2): 736-745. ( PubMed, DOI )

  50. Takayuki Tomita, Takanori Kanai, Teruji Totsuka, Yasuhiro Nemoto, Ryuichi Okamoto, Kiichiro Tsuchiya, Naoya Sakamoto, Toshiaki Ohteki, Toshifumi Hibi, Mamoru Watanabe. IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis. Eur J Immunol. 2009.10; 39 (10): 2737-2747. ( PubMed, DOI )

  51. Taku Sato, Nobuyuki Onai, Hiroki Yoshihara, Fumio Arai, Toshio Suda, Toshiaki Ohteki. Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med. 2009.06; 15 (6): 696-700. ( PubMed, DOI )

  52. Jun Yamada, Junji Hamuro, Atsuki Fukushima, Toshiaki Ohteki, Kazuto Terai, Yoichiro Iwakura, Hideo Yagita, Shigeru Kinoshita. MHC-matched corneal allograft rejection in an IFN-gamma/IL-17-independent manner in C57BL/6 mice. Invest Ophthalmol Vis Sci. 2009.05; 50 (5): 2139-2146. ( PubMed, DOI )

  53. Fumi Miyagawa, Yutaka Tagaya, Brian S Kim, Hiral J Patel, Kazuto Ishida, Toshiaki Ohteki, Thomas A Waldmann, Stephen I Katz. IL-15 serves as a costimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease. J Immunol. 2008.07; 181 (2): 1109-1119. ( PubMed )

  54. Shoko Kuroda, Miki Nishio, Takehiko Sasaki, Yasuo Horie, Koichi Kawahara, Masato Sasaki, Miyuki Natsui, Takashi Matozaki, Hiroyuki Tezuka, Toshiaki Ohteki, Irmgard Förster, Tak W Mak, Toru Nakano, Akira Suzuki. Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol. 2008.05; 38 (5): 1331-1340. ( PubMed, DOI )

  55. Magali Terme, Nathalie Chaput, Behazine Combadiere, Averil Ma, Toshiaki Ohteki, Laurence Zitvogel. Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells. J Immunol. 2008.04; 180 (7): 4679-4686. ( PubMed )

  56. Nobuyuki Onai, Aya Obata-Onai, Michael A Schmid, Toshiaki Ohteki, David Jarrossay, Markus G Manz. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nat Immunol. 2007.11; 8 (11): 1207-1216. ( PubMed, DOI )

  57. Toshiaki Ohteki. The dynamics of dendritic cell: mediated innate immune regulation. Allergol Int. 2007.09; 56 (3): 209-214. ( PubMed, DOI )

  58. Hiroyuki Tezuka, Yukiko Abe, Makoto Iwata, Hajime Takeuchi, Hiromichi Ishikawa, Masayuki Matsushita, Tetsuo Shiohara, Shizuo Akira, Toshiaki Ohteki. Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. Nature. 2007.08; 448 (7156): 929-933. ( PubMed, DOI )

  59. Hiroyuki Kishimoto, Toshiaki Ohteki, Nobuyuki Yajima, Koichi Kawahara, Miyuki Natsui, Satoru Kawarasaki, Koichi Hamada, Yasuo Horie, Yoshiaki Kubo, Seiji Arase, Masaru Taniguchi, Bart Vanhaesebroeck, Tak Wah Mak, Toru Nakano, Shigeo Koyasu, Takehiko Sasaki, Akira Suzuki. The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood. 2007.04; 109 (8): 3316-3324. ( PubMed, DOI )

  60. Toshiaki Ohteki, Hiroyuki Tada, Kazuto Ishida, Taku Sato, Chikako Maki, Taketo Yamada, Junji Hamuro, Shigeo Koyasu. Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. J Exp Med. 2006.10; 203 (10): 2329-2338. ( PubMed, DOI )

  61. Seiichi Kuwajima, Taku Sato, Kazuto Ishida, Hiroyuki Tada, Hiroyuki Tezuka, Toshiaki Ohteki. Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat Immunol. 2006.07; 7 (7): 740-746. ( PubMed, DOI )

  62. Noriko Kitanaka, Yuji Owada, Ryuhei Okuyama, Hiroyuki Sakagami, Mohammad Reza Nourani, Setsuya Aiba, Hiroshi Furukawa, Makoto Watanabe, Masao Ono, Toshiaki Ohteki, Hisatake Kondo. Epidermal-type fatty acid binding protein as a negative regulator of IL-12 production in dendritic cells. Biochem Biophys Res Commun. 2006.06; 345 (1): 459-466. ( PubMed, DOI )

  63. Hiroyuki Tada, Setsuya Aiba, Ken-Ichiro Shibata, Toshiaki Ohteki, Haruhiko Takada. Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells. Infect Immun. 2005.12; 73 (12): 7967-7976. ( PubMed, DOI )

  64. Kaisa Holmberg, Sanjeev Mariathasan, Toshiaki Ohteki, Pamela S Ohashi, Nicholas R J Gascoigne. TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. J Immunol. 2003.09; 171 (5): 2427-2434. ( PubMed )

  65. Kenya Honda, Shinya Sakaguchi, Chigusa Nakajima, Ai Watanabe, Hideyuki Yanai, Misako Matsumoto, Toshiaki Ohteki, Tsuneyasu Kaisho, Akinori Takaoka, Shizuo Akira, Tsukasa Seya, Tadatsugu Taniguchi. Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci USA. 2003.09; 100 (19): 10872-10877. ( PubMed, DOI )

  66. Toshimasa Yamauchi, Junji Kamon, Yusuke Ito, Atsushi Tsuchida, Takehiko Yokomizo, Shunbun Kita, Takuya Sugiyama, Makoto Miyagishi, Kazuo Hara, Masaki Tsunoda, Koji Murakami, Toshiaki Ohteki, Shoko Uchida, Sato Takekawa, Hironori Waki, Nelson H Tsuno, Yoichi Shibata, Yasuo Terauchi, Philippe Froguel, Kazuyuki Tobe, Shigeo Koyasu, Kazunari Taira, Toshio Kitamura, Takao Shimizu, Ryozo Nagai, Takashi Kadowaki. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003.06; 423 (6941): 762-769. ( PubMed, DOI )

  67. Samuel D Saibil, Toshiaki Ohteki, Forest M White, Mark Luscher, Arsen Zakarian, Alisha Elford, Jeffery Shabanowitz, Hiroshi Nishina, Patrice Hugo, Josef Penninger, Brian Barber, Donald F Hunt, Pamela S Ohashi. Weak agonist self-peptides promote selection and tuning of virus-specific T cells. Eur J Immunol. 2003.03; 33 (3): 685-696. ( PubMed, DOI )

  68. Harumi Suzuki, Satoshi Matsuda, Yasuo Terauchi, Mari Fujiwara, Toshiaki Ohteki, Tomoichiro Asano, Timothy W Behrens, Taku Kouro, Kiyoshi Takatsu, Takashi Kadowaki, Shigeo Koyasu. PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction. Nat Immunol. 2003.03; 4 (3): 280-286. ( PubMed, DOI )

  69. Yukie Murata, Toshiaki Ohteki, Shigeo Koyasu, Junji Hamuro. IFN-gamma and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension. Eur J Immunol. 2002.10; 32 (10): 2866-2873. ( PubMed, DOI )

  70. Toshiaki Ohteki. Critical role for IL-15 in innate immunity. Curr Mol Med. 2002.06; 2 (4): 371-380. ( PubMed )

  71. Kristine M Garza, Kim J McKall-Faienza, Toshiaki Otheki, Arsen Zakarian, Bernhard Odermatt, Pamela S Ohashi. Enhanced T cell responses contribute to the genetic predisposition of CD8-mediated spontaneous autoimmunity. Eur J Immunol. 2002.03; 32 (3): 885-894. ( PubMed, DOI )

  72. T Ohteki, K Suzue, C Maki, T Ota, S Koyasu. Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat Immunol. 2001.12; 2 (12): 1138-1143. ( PubMed, DOI )

  73. T Ohteki, C Maki, S Koyasu. Overexpression of Bcl-2 differentially restores development of thymus-derived CD4-8+ T cells and intestinal intraepithelial T cells in IFN-regulatory factor-1-deficient mice. J Immunol. 2001.06; 166 (11): 6509-6513. ( PubMed )

  74. A Suzuki, M T Yamaguchi, T Ohteki, T Sasaki, T Kaisho, Y Kimura, R Yoshida, A Wakeham, T Higuchi, M Fukumoto, T Tsubata, P S Ohashi, S Koyasu, J M Penninger, T Nakano, T W Mak. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. 2001.05; 14 (5): 523-534. ( PubMed )

  75. T Ohteki, S Koyasu. Role of antigen-presenting cells in innate immune system. Arch Immunol Ther Exp (Warsz.). 2001.01; 49 Suppl 1 S47-S52. ( PubMed )

  76. T Ohteki, M Parsons, A Zakarian, R G Jones, L T Nguyen, J R Woodgett, P S Ohashi. Negative regulation of T cell proliferation and interleukin 2 production by the serine threonine kinase GSK-3. J Exp Med. 2000.07; 192 (1): 99-104. ( PubMed )

  77. T Ohteki, A Hessel, M F Bachmann, A Zakarian, E Sebzda, M S Tsao, K McKall-Faienza, B Odermatt, P S Ohashi. Identification of a cross-reactive self ligand in virus-mediated autoimmunity. Eur J Immunol. 1999.09; 29 (9): 2886-2896. ( PubMed, DOI )

  78. T Ohteki, T Fukao, K Suzue, C Maki, M Ito, M Nakamura, S Koyasu. Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells. J Exp Med. 1999.06; 189 (12): 1981-1986. ( PubMed )

  79. T Ohteki, C Maki, S Koyasu, T W Mak, P S Ohashi. Cutting edge: LFA-1 is required for liver NK1.1+TCR alpha beta+ cell development: evidence that liver NK1.1+TCR alpha beta+ cells originate from multiple pathways. J Immunol. 1999.04; 162 (7): 3753-3756. ( PubMed )

  80. E Sebzda, S Mariathasan, T Ohteki, R Jones, M F Bachmann, P S Ohashi. Selection of the T cell repertoire. Annu Rev Immunol. 1999.01; 17 829-874. ( PubMed, DOI )

  81. S Mariathasan, M F Bachmann, D Bouchard, T Ohteki, P S Ohashi. Degree of TCR internalization and Ca2+ flux correlates with thymocyte selection. J Immunol. 1998.12; 161 (11): 6030-6037. ( PubMed )

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  117. 金山剛士, 樗木俊聡. 感染時に出現する調節性B細胞 実験医学増刊　ヒト疾患と免疫細胞サブセット. 2024.07; 42 (12):

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  119. 泉　湧太, 金山　剛士, 樗木　俊聡. マクロファージ分化経路とその治療標的としての可能性 実験医学. 2022.03; 40 (5): 705-709.

  120. 樗木　俊聡. 樹状細胞への運命決定 呼吸器内科. 2021.12; 40 (6): 632-636.

  121. 樗木　俊聡. 第49回日本免疫学会学術集会 感染 炎症 免疫. 2021.10; 51 (2): 63-65.

  122. 佐藤　卓, 樗木　俊聡. 組織再生を担う腸幹細胞の維持と機能 生化学. 2021.08; 93 (4): 503-511.

  123. 佐藤　卓, 樗木　俊聡. 腸管上皮細胞におけるインターフェロンの役割 臨床免疫・アレルギー科. 2021.06; 75 (6): 759-764.

  124. 金山　剛士, 樗木　俊聡. 高サイトカイン血症と単球・マクロファージ 実験医学. 2021.03; 39 (4): 512-516.

  125. 佐藤卓、樗木俊聡. 腸幹細胞の維持にはIFNシグナルの抑制が重要 ネイチャー・ダイジェスト. 2021.02; 18 (2): 22-25.

  126. 佐藤　卓, 樗木　俊聡. 腸幹細胞の維持にはIFNシグナルの抑制が重要 natureダイジェスト. 2021.02; 18 (2): 22-25.

  127. 泉　湧太, 金山　剛士, 川村　俊輔, 樗木　俊聡. 単球・マクロファージの分化経路 血液内科. 2021.01; 83 (1): 1-7.

  128. 石川駿、佐藤卓、村川泰裕、樗木俊聡. NET-CAGE法を用いたエンハンサー解析と病態解明 月刊 糖尿病・内分泌代謝科. 2020.10; 51 (4):

  129. 樗木　俊聡. 特集：マクロファージの功罪 医学のあゆみ. 2020.06; 273 (10): 925.

  130. 小内　伸幸, 樗木　俊聡. アレルギーにおける樹状細胞の役割 実験医学. 2019.06; 37 (10): 42-48.

  131. 樗木俊聡. 総論　マクロファージの可塑性と組織適応 月刊「細胞」2019年1月号　vol.51, No.1, 2019(通巻674号）. 2018.12; 51 (674): 6-7.

  132. 小内　伸幸, 樗木　俊聡. 単球由来マクロファージの前駆細胞 炎症と免疫. 2018.05; 26 (3): 17-24.

  133. 樗木　俊聡. ヒトにおける共通単球前駆細胞の同定 感染・炎症・免疫. 2018.04; 48 (1): 18-25.

  134. 小内伸幸,川村俊輔,樗木俊聡. 単球由来マクロファージの前駆細胞 炎症と免疫. 2018.04; 26(3) (5月): 17-24.

  135. 樗木　俊聡. ヒト単球前駆細胞cMoPの同定-マウスcMoPのカウンターパート- 臨床血液. 2018; 59 (6): 812-818. ( PubMed, DOI )

  136. 小内　伸幸, 樗木　俊聡. 血球貪食症候群の発症機構と免疫学的意義 血液内科. 2017.11; 75 (5): 591-597.

  137. 川村俊輔、樗木俊聡. ヒトにおける共通単球前駆細胞の同定 ライフサイエンス　新着論文レビュー. 2017.06; ( DOI )

  138. 樗木俊聡. マクロファージの分化と多様性（「免疫学のABC」第２回） 分子リウマチ治療 2017年2月号 Vol 10. No.1. 2017.05;

  139. 小内伸幸、樗木俊聡　. 樹状細胞前駆細胞および樹状細胞サブセットのソーティング 実験医学 別冊 最強のステップUPシリーズ 新版！フローサイトメトリー. 2016.09; 229-240.

  140. 川村俊輔、小内伸幸、樗木俊聡. マクロファージの発生・分化 JSI Newletter vol.24 No.2 特集「マクロファージ」日本免疫学会会報. 2016.04; 16.

  141. 樗木俊聡. マクロファージ・樹状細胞の起源と多様性 医学のあゆみ 259巻5号 マクロファージのすべて. 2016.01; 347-352.

  142. 樗木俊聡、小内伸幸. 制御性血球貪食樹状細胞 炎症と免疫 2015年11月号. 2015.10; 60-64.

  143. 樗木俊聡、小内伸幸. 樹状細胞の分化経路 臨床免疫・アレルギー科 62 (6). 2014.12; 569-574.

  144. 手塚裕之, 安倍由紀子, 黒田聖子, 樗木俊聡. IgA生産を制御する樹状細胞サブセット 臨床免疫・アレルギー科. 2014.12; 62 (6): 593-599.

  145. 樗木俊聡. 血球貪食減少の新たな視点 臨床血液. 2014.10; 55 (10): 49-53.

  146. 小内伸幸、樗木俊聡. plasmacytoid dendritic cellの分化とその制御 医学のあゆみ. 2014.09; 250 (11): 1044-1045.

  147. 大八木秀明、小内伸幸、澤田賢一、樗木俊聡. 血球貪食症候群の病態解明の進歩：単球に由来する樹状細胞による血球の貪食と新しい免疫寛容誘導の仕組み 血液内科 第69巻第２号. 2014.08; 279-284.

  148. 大八木秀明、小内伸幸、澤田賢一、樗木俊聡. 樹状細胞による免疫寛容誘導の最新情報：単球に由来する樹状細胞による血球の貪食と新しい免疫寛容誘導の仕組み Surgery Frontier 2014 (21) 3 特集:生体防御における免疫反応の新知見. 2014.06; 19-24.

  149. 上羽悟史、小内伸幸、松島綱治、樗木俊聡. 樹状細胞・マクロファージサブセットの起源と生体内移動 実験医学 増刊 炎症 32(17). 2014.06; 31-37.

  150. 樗木俊聡、小内伸幸. 樹状細胞の新しい前駆細胞 炎症と免疫. 2013.12; 22 (1): 41-46.

  151. 小内伸幸、樗木俊聡. 単球に由来する樹状細胞による血球の貪食と免疫反応の制御 ライフサイエンス　新着論文レビュー. 2013.10; ( DOI )

  152. 樗木俊聡. 単球由来樹状細胞による過剰免疫応答の制御 細胞工学. 2013.06; 32 (12): 1211-1214.

  153. 樗木俊聡. 樹状細胞、NK細胞の基礎知識 HORMONE FRONTEER IN GYNECOLOGY 特集　生殖と自然免疫 Vol 20, No1.. 2013.06; 21-26.

  154. 小内伸幸、樗木俊聡. 形質細胞様樹状細胞への卓越した分化能をもつ新しい樹状細胞前駆細胞の発見 ライフサイエンス　新着論文レビュー. 2013.05; ( DOI )

  155. 小内伸幸、大八木秀明　澤田賢一、樗木俊聡. 樹状細胞による新しい免疫寛容誘導の仕組み 医薬ジャーナル 2013年2月号(Vol.49, No.2). 2013.01; 95-100.

  156. 樗木俊聡、手塚裕之. 腸管粘膜防御機構を担うIgA抗体の新たな産生機構（形質細胞様樹状細胞のユニークな役割） 炎症と免疫　20. 2012.06; 178-182.

  157. 樗木俊聡、手塚裕之. pDCによる新たなIgA生産誘導メカニズム 医学のあゆみ 240. 2012.06; 185-183.

  158. 手塚裕之、安部由紀子、樗木俊聡. T細胞非依存性IgA生産における樹状細胞の役割 臨床免疫•アレルギー科　58(3). 2012.05; 283-289.

  159. 樗木俊聡. pDCによる新たなIgA生産誘導の仕組み 感染　炎症　免疫　Vol.41.No.4. 2011.06; 83-84.

  160. 手塚裕之、安部由紀子、樗木俊聡. 形質細胞様樹状細胞によるT細胞非依存性IgA生産誘導機構 臨床免疫•アレルギー科　55. 2011.06; 687-692.

  161. 樗木俊聡、手塚裕之. T細胞非依存性IgA産生誘導における形質細胞様樹状細胞の質的優位性 細胞工学30 (No.4). 2011.03; 376-380.

  162. 樗木俊聡、佐藤　卓. インターフェロンによる造血幹細胞の運命決定制御 実験医学　増刊　28(12). 2010.06; 152-156.

  163. 佐藤　卓、樗木俊聡. インターフェロンと白血病幹細胞 血液フロンティア　20. 2010.06; 139-147.

  164. 樗木俊聡、手塚裕之. TNF/iNOS産生DCとIgA分泌 医学のあゆみ 234(5). 2010.06; 453-457.

  165. 手塚裕之・安部由紀子・樗木俊聡. 消化管粘膜におけるIgA生産機構 炎症と免疫 17. 2009.10; 86-92.

  166. 手塚裕之・安部由紀子・樗木俊聡. 粘膜関連リンパ組織におけるT細胞非依存性IgAクラススイッチ誘導機構 臨床免疫・アレルギー科 52. 2009.06; 422-430.

  167. 樗木俊聡・佐藤卓. 眠れる造血幹細胞を目覚めさせるインターフェロン DENTAL DIAMOND 34. 2009.06; 80-85.

  168. 手塚裕之・安部由紀子・樗木俊聡. 腸管における樹状細胞のトラフィッキングとIgA生産誘導機構 臨床免疫・アレルギー科 49(1). 2008.10; 10-15.

  169. 安部由紀子、手塚裕之、樗木俊聡. 粘膜樹状細胞によるIgAクラススイッチ誘導機構 感染・炎症・免疫 38(3). 2008.06; 271-274.

  170. 小内伸幸・樗木俊聡. 樹状細胞によるTh分化制御 分子細胞治療 7(3). 2008.06; 162-170.

  171. 樗木俊聡、安部由紀子、手塚裕之. 樹状細胞によるIgA生産誘導機構の新知見 炎症と免疫 16(2). 2008.03; 209-214.

  172. 手塚裕之、安部由紀子、樗木俊聡. IgAクラススイッチを誘導するパイエル板樹状細胞 臨床免疫・アレルギー科 50. 2008.03; 216-221.

  173. 手塚裕之、安部由紀子、樗木俊聡. 腸管でのIgA生産を司るTNF/iNOS生産性樹状細胞とその作用機構 生体の科学 59(4). 2008.03; 268-274.

  174. 手塚裕之、安部由紀子、樗木俊聡. 腸管粘膜樹状細胞によるIgAクラススイッチ制御ー腸内常在菌の役割 医学のあゆみ 227(5). 2008.02; 326-331.

  175. 手塚裕之、安部由紀子、樗木俊聡. 消化管粘膜での免疫応答における樹状細胞の役割ー小腸粘膜樹状細胞によるクラススイッチ制御 実験医学 26(20). 2008.02; 3236-3242.

  176. 樗木俊聡・多田浩之. IL-15による炎症反応の制御 感染・炎症・免疫, 37(1). 2007.10; 10-16.

  177. 桑島精一・樗木俊聡. CpGオリゴヌクレオチドによる樹状細胞からのIL-12生産メカニズム 臨床免疫・アレルギー科, 47(5). 2007.06; 603-609.

  178. 手塚裕之、安部由紀子、樗木俊聡. 樹状細胞によるIgAクラススイッチ誘導機構 臨床免疫・アレルギー科, 48(3). 2007.06; 230-235.

  179. 多田浩之・樗木俊聡. 樹状細胞からのIL-15生産と炎症 臨床免疫・アレルギー科, 48(3). 2007.06; 340-346.

  180. 手塚裕之、安部由紀子、樗木俊聡. 粘膜TiP-DCによるIgA生産誘導機構 臨床免疫・アレルギー科, 47(6). 2007.06; 619-624.

  181. 小内伸幸、小内亜矢、樗木俊聡、. 樹状細胞サブセットの分化経路 生化学, 79(12). 2007.02; 1143-1148.

  182. 樗木俊聡・石田和人. [私達の研究] 免疫疾患におけるインターロイキン-15の役割 化学療法の領域 22. 2006.09; 95-99.

  183. 佐藤　卓、樗木俊聡. 樹状細胞のサイトカインを介する生体防御機構 臨床免疫45. 2006.09; 192-196.

  184. 樗木俊聡. CpG DNAによる免疫賦活機構の新知見 東北のコロニー 33. 2006.06; 3-9.

  185. 佐藤　卓、木俊聡. 消化管免疫24. 生体防御におけるIELおよび腸管DCの機能 別冊医学のあゆみ 消化器疾患 states of arts I. 消化管（食道・胃・腸）Ver. 3. 2006.02; 89-92.

  186. 桑島精一、樗木俊聡. IL-15による自然免疫賦活メカニズム 実験医学増刊号 免疫研究最前線2007 24. 2006.02; 3154-3160.

  187. 多田浩之、樗木俊聡. 自然免疫と獲得免疫の基礎：自然免疫と感染免疫における樹状細胞の役割 最新医学 60. 2005.11; 597-604.

  188. 佐藤　卓、樗木俊聡. 感染からの回避機構．わかりやすい免疫疾患 日本医師会雑誌 134　特別号. 2005.10; 76-77.

  189. 佐藤　卓、樗木俊聡. 感染におけるTh1/Th2反応 Surgery Frontier 12. 2005.06; 31-36.

  190. 手塚裕之、樗木俊聡. 樹状細胞が生産するサイトカインによるB細胞の機能調節 臨床免疫 44. 2005.03; 109-112.

  191. 樗木俊聡. IL-15の免疫反応および免疫疾患における役割 Molecular Medicine 41 （臨時増刊号）. 2004.11; 262-268.

  192. 樗木俊聡. 自然免疫と獲得免疫の連携における樹状細胞の役割 医学のあゆみ 205. 2003.03; 57-61.

  193. 樗木俊聡. 樹状細胞の活性化におけるIL-15の役割 現代医療 35. 2003.03; 1807-1812.

  194. 樗木俊聡. インターロイキン-15による生体防御調節機構 東北大学歯学雑誌 21. 2002.03; 53-60.

  195. 樗木俊聡. IL-15による樹状細胞機能の調節 2002.03; 2139-2144.

  196. 樗木俊聡、小安重夫. 樹状細胞によるTh1/Th2バランスの制御と疾病 Molecular Medicine 38. 2001.11; 1356-1362.

  197. 樗木俊聡、小安重夫. 樹状細胞の分化・機能発現とサイトカイン制御 Molecular Medicine 臨時増刊号「免疫2001-02」. 2001.03; 180-188.

  198. 樗木俊聡. 肝NK1.1+TCRab+ 細胞の由来と分化 臨床免疫 35. 2001.03; 657-660.

  199. 樗木俊聡. 樹状細胞、マクロファージの機能とIFNg、IL-15 臨床免疫 36. 2001.03; 204-210.

  200. 樗木俊聡. MACSによる樹状細胞の単離と機能解析 臨床免疫 34. 2000.10; 848-854.

  201. 小安重夫、樗木俊聡、深尾太郎、鈴江一友. 自然免疫における樹状細胞の機能 細胞 32. 2000.06; 212-215.

  202. 樗木俊聡、牧稚佳子、鈴江一友、小安重夫. 原始的生体防御反応とその後のTh1細胞分化へ影響を及ぼす遺伝的背景 別冊医学のあゆみ 生体防御の新展開. 1999.10; 119-112.

  203. 樗木俊聡、小安重夫. NK細胞、NKT細胞の分化 実験医学 17. 1999.06; 39-43.

  204. 樗木俊聡、安保徹. 胸腺外T細胞分化 Biomedica 7. 1992.10; 92-97.

  205. 樗木俊聡、新田康隆、熊谷勝男. 癌転移の臓器特異性を決定する接着分子と増殖因子 実験医学 10. 1992.06; 24-29.

  206. 安保徹、樗木俊聡. gdT細胞の誘導 臨床免疫 23. 1991.06; 1113-1121.

  207. 樗木俊聡、熊谷勝男. サイトカインネットワーク 1990.06; 1012-1013.

  208. 樗木俊聡、安保徹、熊谷勝男. 樗木俊聡・安保徹・熊谷勝男「腸管感染とgdT細胞 Medical Immunology 19. 1990.06; 439-445.

  209. 樗木俊聡、安保徹、熊谷勝男. 樗木俊聡・安保徹・熊谷勝男「肝類洞と腸管上皮内gdT細胞 Human Cell 3. 1990.04; 233-240.

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