Personnel Information

写真a

NAKANISHI Akira


Job title

Associate Professor

Mail Address

nakanishi.mgen@mri.tmd.ac.jp

Campus Career 【 display / non-display

  • 2009.07
    -
    2013.03
    Tokyo Medical and Dental University, Medical Research Institute, Medical Genomics, Molecular Genetics, Project Associate Professor
  • 2013.03
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Medical Genomics, Molecular Genetics, Associate Professor
  • 2013.03
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Advanced Therapeutic Sciences, Applied Gene Medicine, Associate Professor

Research Areas 【 display / non-display

  • Molecular biology

  • Cell biology

 

Published Papers & Misc 【 display / non-display

  1. Mio Fukuda, Yo Tojo, Ami Sato, Hiroko Saito, Akira Nakanishi, Yoshio Miki. BRCA2 represses the transcriptional activity of pS2 by E2-ERalpha Biochemical and Biophysical Research Communications. 2022.01;

  2. Gerelmaa Enkhbat, Akira Nakanishi, Yoshio Miki. The BRCA2 missense mutation K2497R suppressed self-degradation and increased ATP production and cell proliferation Biochemical and Biophysical Research Communications. 2022.01;

  3. Yang Gao, Naoe Taira Nihira  他. Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy Nature Cell Biology. 2020.08;

  4. Torii S 他. Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy. Naure Communications. 2020.04; 11 (1): ( PubMed, DOI )

  5. Yu Deng, Yoshio Miki, Akira Nakanishi. Estradiol/GPER affects the integrity of mammary duct-like structures in vitro Scientific reports. 2020.01; ( PubMed, DOI )

  6. Sunada S, Nakanishi A, Miki Y. Crosstalk of DNA double-strand break repair pathways in poly(ADP-ribose) polymerase inhibitor treatment of breast cancer susceptibility gene 1/2-mutated cancer. Cancer Science. 2018.04; 109 (4): 893-899.

  7. Takaoka M, Ito S, Miki Y, Nakanishi A.. FKBP51 regulates cell motility and invasion via RhoA signaling. Cancer Science. 2017.03; 108 (3): 380-389.

  8. Torii S, Yoshida T, Arakawa S, Honda S, Nakanishi A, Shimizu S.. Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress-induced autophagy. EMBO Reports. 2016.11; 17 (11): 1552-1564.

  9. Malik S, Saito H, Takaoka M, Miki Y, Nakanishi A.. BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein. Cell Cycle. 2016.07; 19 1-12. ( PubMed )

  10. Kimura Hitomi, Miki Yoshio, Nakanishi Akira. Centrosomes at M phase act as a scaffold for the accumulation of intracellular ubiquitinated proteins. Cell Cycle. 2014.06; 13 (12): 1928-1937. ( PubMed, DOI )

  11. Takaoka Miho, Saito Hiroko, Takenaka Katsuya, Miki Yoshio, Nakanishi Akira. BRCA2 phosphorylated by PLK1 moves to the midbody to regulate cytokinesis mediated by nonmuscle myosin IIC. Cancer Res. 2014.03; 74 (5): 1518-1528. ( PubMed, DOI )

  12. Wali Nadila, Hosokawa Kana, Malik Sadiya, Saito Hiroko, Miyaguchi Ken, Imajoh-Ohmi Shinobu, Miki Yoshio, Nakanishi Akira. Centrosomal BRCA2 is a target protein of membrane type-1 matrix metalloproteinase (MT1-MMP). Biochem Biophys Res Commun. 2014.01; 443 (4): 1148-1154. ( PubMed, DOI )

  13. Ishiba Toshiyuki, Nagahara Makoto, Nakagawa Tsuyoshi, Sato Takanobu, Ishikawa Toshiaki, Uetake Hiroyuki, Sugihara Kenichi, Miki Yoshio, Nakanishi Akira. Periostin suppression induces decorin secretion leading to reduced breast cancer cell motility and invasion. Sci Rep. 2014; 4 7069. ( PubMed, DOI )

  14. Wang Hui-Feng, Takenaka Katsuya, Nakanishi Akira, Miki Yoshio. BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2. Cancer Res. 2011.01; 71 (1): 68-77. ( PubMed, DOI )

  15. Niwa Takayoshi, Saito Hiroko, Imajoh-ohmi Shinobu, Kaminishi Michio, Seto Yasuyuki, Miki Yoshio, Nakanishi Akira. BRCA2 interacts with the cytoskeletal linker protein plectin to form a complex controlling centrosome localization. Cancer Sci. 2009.11; 100 (11): 2115-2125. ( PubMed, DOI )

  16. Tomiyoshi G, Nakanishi A, Takenaka K, Yoshida K, Miki Y. Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage Cancer Sci. 2008; 99 (4): 747-754. ( PubMed, DOI )

  17. Han X, Saito H, Miki Y, Nakanishi A. A CRM1-mediated nuclear export signal governs cytoplasmic localization of BRCA2 and is essential for centrosomal localization of BRCA2 Oncogene. 2008; 27 (21): 2969-2977. ( PubMed, DOI )

  18. Noda H, Miyaji Y, Nakanishi A, Konishi F, Miki Y. Frequent reduced expression of alpha-1B-adrenergic receptor caused by aberrant promoter methylation in gastric cancers Br J Cancer. 2007; 96 (2): 383-390. ( PubMed, DOI )

  19. Nakanishi A, Han X, Saito H, Taguchi K, Ohta Y, Imajoh-Ohmi S, Miki Y. Interference with BRCA2, which localizes to the centrosome during S and early M phase, leads to abnormal nuclear division Biochem Biophys Res Commun. 2007; 355 (1): 34-40. ( PubMed, DOI )

  20. Nakanishi A, Imajoh-Ohmi S, Hanaoka F. Characterization of the interaction between DNA gyrase inhibitor and DNA gyrase of Escherichia coli J Biol Chem. 2002; 277 (11): 8949-8954. ( PubMed, DOI )

  21. Nakanishi A, Imajoh-Ohmi S. [DNA gyrase inhibitor (GyrI) of Escherichia coli] Seikagaku. 1999; 71 (6): 442-448. ( PubMed )

  22. Nakanishi A, Oshida T, Matsushita T, Imajoh-Ohmi S, Ohnuki T. Identification of DNA gyrase inhibitor (GyrI) in Escherichia coli J Biol Chem. 1998; 273 (4): 1933-1938. ( PubMed )

  23. Kikuchi H, Fujinawa T, Kuribayashi F, Nakanishi A, Imajoh-Ohmi S, Goto M, Kanegasaki S. Induction of essential components of the superoxide generating system in human monoblastic leukemia U937 cells J Biochem. 1994; 116 (4): 742-746. ( PubMed )

  24. Nakanishi A, Imajoh-Ohmi S, Fujinawa T, Kikuchi H, Kanegasaki S. Direct evidence for interaction between COOH-terminal regions of cytochrome b558 subunits and cytosolic 47-kDa protein during activation of an O(2-)-generating system in neutrophils J Biol Chem. 1992; 267 (27): 19072-19074. ( PubMed )

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Conference Activities & Talks 【 display / non-display

  1. 平山栞「他」. Elucidation of the BRCA2 nuclear transport system. 第80回日本癌学会学術総会 2021.09.30

  2. Yo Tojo、Akira Nakanishi、 Yoshio Miki. Physiological role of centrosome pairs during S phase. 第80回日本癌学会学術総会 2021.09.30

  3. Yo Tojo、Akira Nakanishi、 Yoshio Miki. The physiological role of centrosome pairs during S phase. 第79回日本癌学会学術総会 2020.10.01

  4. Deng Yu、Akira Nakanishi、 Yoshio Miki. The role of BRCA2 in H3K4 methylation mediated by MLL. 第79回日本癌学会学術総会 2020.10.01

  5. Gerelmaa Enkhbat、Uetake Hiroyuki、Akira Nakanishi、Yoshio Miki. Elucidation of the regulation mechanism of BRCA2 protein levels in the cell cycle. 第79回日本癌学会学術総会 2020.10.01

  6. Deng Yu 「他」. Analysis of disruption mechanism of the ductal-like structures and basement membrane by estrogen. 第42回日本分子生物学会年会 2019.12.06

  7. 東條 陽「他」. Action of estrogen-mediated BRCA2. 第42回日本分子生物学会年会 2019.12.06

  8. Deng Yu. Mechanism of breast duct and basement membrane disruption caused by estradiol. 第78回日本癌学会学術総会 2019.09.28

  9. 東條 陽、他. Action of estrogen-mediated BRCA2. 第78回日本癌学会学術総会 2019.09.27

  10. 石場俊之. Calretinin can be the specific marker for breast phyllodes tumor. 第78回日本癌学会学術総会 2019.09.27

  11. Gerelmaa Enkhbat、他. Elucidation of the regulation mechanism of BRCA2 protein levels in the cell cycle. 第78回日本癌学会学術総会 2019.09.26

  12. Deng Yu、中西啓、三木義男. エストロゲンによる乳管構造および基底膜崩壊機構の解明. 第41回日本分子生物学会 2018.11.30

  13. Gerelmaa Enkhbat, Yoshio Miki, Hiroyuki Uetake, Akira Nakanishi. Elucidation of the regulation mechanism of BRCA2 protein levels in cell cycly. 第41回日本分子生物学会 2018.11.29

  14. 東條陽、中西啓、三木義男. BRCA2とエストロゲン受容体相互作用による生理的役割の解明. 第41回日本分子生物学会 2018.11.29

  15. 東條 陽「他」. Analysis of the function of estrogen-mediated BRCA2. 第77回日本癌学会学術総会 2018.09.29

  16. Deng Yu「他」. Analysis of disruption mechanism of the breast duct and basement membrane by estradiol. 第77回日本癌学会学術総会 2018.09.29

  17. Deng Yu 他. The effects of estrogen in MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures.. 2017.12.09

  18. Yo Tojo 他. The physiological roles of the interaction of BRCA2 with estrogen receptor. ConBio2017 2017.12.09

  19. Syota Yamada 他. Analysis of synthetic lethality with paclitaxel in BRCA2-deficient cells. ConBio2017 2017.12.08

  20. Syota Yamada. Analysis of synthetic lethality with paclitaxel in BRCA2-deficient cells. ConBio2017 2017.12.08

  21. DengYu 他. The effects of estrogen in MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures.. ConBio2017 2017.12.08

  22. Yo Tojo 他. The physiological roles of the interaction of BRCA2 with estrogen receptor. 2017.12.08

  23. Ami Sato. BRCA2 and estrogen receptor are translocated to nucleus via KPNA7. 2017.12.06

  24. Miho Takaoka , Akira Nakanishi, Yoshio Miki. The new subcellular role of BRCA2 involved in FIP3-dependent endosome function . ICHG2016 [The 13th International Congress of Human Genetics] 2016.04.05 Kyoto International Conference Center

  25. Hiroko Saito , Miho Takaoka, Akira Nakanishi, Yoshio Miki.. Loss of BRCA2 enhances microtubules more st abilization with PTX treatment.. Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer 2016.02.19 Hyatt Regency Maui Maui, Hawaii, USA

  26. Toshiyuki Ishiba et al.. Proteomics of phyllodes tumor revealed that decorin increase in the extracellular matrix by periostin deficiency decreased cancer cell motility and invasion. AACR Annual Meeting 2014 2014.04.09 San Diego, California

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