Personnel Information

写真a

GOTO Toshiyasu


Job title

Associate Professor

Laboratory Address

Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan

Laboratory Phone number

+81-3-5803-4903

Laboratory Fax number

+81-3-5803-4903

Mail Address

toshiyasu_goto@hotmail.com

Research Areas, Keywords

gastrulation
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Graduating School 【 display / non-display 】

  • Kwansei Gakuin University, Faculty of Science, Department of Chemistry, 1995, Graduated

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Graduate School 【 display / non-display 】

  • Kyoto University, Graduate School, Division of Natural Science, Biology, Doctor's Course, 2000, Completed

  • Kwansei Gakuin University, Graduate School, Division of Natural Science, Chemistry, Master's Course, 1997, Completed

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Degree 【 display / non-display 】

  • PhD, Kyoto University

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Campus Career 【 display / non-display 】

  • 2008.11
    -
    2009.09
    Tokyo Medical and Dental University， Graduate School of Medical and Dental Sciences， Life Science and Technology， Life Science and Technology， Molecular Cell Biology， Project Junior Associate Professor
  • 2009.10
    -
    2022.04
    Tokyo Medical and Dental University， Medical Research Institute， Advanced Molecular Medicine， Molecular Cell Biology， Associate Professor
  • 2022.05
    -
    Now
    Tokyo Medical and Dental University， Medical Research Institute， Division of Visionary Life Science， Department of Molecular Cell Biology， Associate Professor
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External Career 【 display / non-display 】

  • 2000.04-2003.04 University of Virginia, Department of Biology, Research Associate,
  • 2003.04-2004.03 JST, SORST, Researcher,
  • 2004.04-2008.10 JST, ICORP, Researcher,
  • 2008.11-2009.09 Tokyo Medical and Dental University, Senior Assistant Professor,
  • 2009.10- Tokyo Medical and Dental University, Associate Professor,
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Academic Activity 【 display / non-display 】

  • Committee of the Graduate School of Medicine
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Research Areas 【 display / non-display 】

  • Developmental biology

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Qualification Acquired 【 display / non-display 】

  • Chief Person of Radiation Handling （first and second kind）

  • Hazardous Material Handler (first kind)

  • X-ray Work Chief Person

  • Gamma Ray Penetration Photography Work Chief Person

  • Health Supervisor (first kind)

  • Person in Charge of Poison and Deleterious Substance Handling

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Published Papers & Misc 【 display / non-display 】

  1. Goto Toshiyasu, Michiue Tatsuo, Shibuya Hiroshi. ccl19 and ccl21 affect cell movements and differentiation in early Xenopus development DEVELOPMENT GROWTH & DIFFERENTIATION. 2023.04; 65 (3): 175-189. ( PubMed, DOI )

  2. Goto Toshiyasu, Shibuya Hiroshi. maea affects head formation through beta-catenin degradation during early Xenopus laevis development DEVELOPMENT GROWTH & DIFFERENTIATION. 2022.12; ( PubMed, DOI )

  3. Goto T, Michiue T, Shibuya H. ccr7 affects both morphogenesis and differentiation during early Xenopus embryogenesis. Development, growth & differentiation. 2022.05; 64 (5): 254-260. ( PubMed, DOI )

  4. Goto T, Keller R. Preparation of three-notochord explants for imaging analysis of the cell movements of convergent extension during early Xenopus morphogenesis. Development, growth & differentiation. 2021.10; ( PubMed, DOI )

  5. Sato Atsushi, Shimizu Masahiro, Goto Toshiyasu, Masuno Hiroyuki, Kagechika Hiroyuki, Tanaka Nobuyuki, Shibuya Hiroshi. WNK regulates Wnt signalling and beta-Catenin levels by interfering with the interaction between beta-Catenin and GID COMMUNICATIONS BIOLOGY. 2020.11; 3 (1): 666. ( PubMed, DOI )

  6. Espiritu EB, Crunk AE, Bais A, Hochbaum D, Cervino AS, Phua YL, Butterworth MB, Goto T, Ho J, Hukriede NA, Cirio MC. The Lhx1-Ldb1 complex interacts with Furry to regulate microRNA expression during pronephric kidney development. Scientific reports. 2018.10; 8 (1): 16029. ( PubMed, DOI )

  7. Goto T, Ito Y, Michiue T.. Roles of Xenopus chemokine ligand CXCLh (XCXCLh) in early embryogenesis. Dev Growth Differ. . 2018.04; 60 226-238.

  8. Michiue T, Yamamoto T, Yasuoka Y, Goto T, Ikeda T, Nagura K, Nakayama T, Taira M, Kinoshita T.. High variability of expression profiles of homeologous genes for Wnt, Hh, Notch, and Hippo signaling pathways in Xenopus laevis. Dev Biol.. 2017.06; 426 (2): 270-290. ( PubMed, DOI )

  9. Goto T, Matsuzawa J, Iemura S, Natsume T, Shibuya H.. WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway. FEBS Lett.. 2016.05; 590 (9): 1291-1303. ( PubMed, DOI )

  10. Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, Kato-Sumida T, Koike Y, Abe M, Nonaka Y, Ikura T, Ito N, Shibuya H, Hosoya T, Hagiwara M.. Selective inhibition of the kinase DYRK1A by targeting its folding process. Nat Commun.. 2016.04; ( PubMed, DOI )

  11. Goto T, Sato A, Adachi S, Iemura S, Natsume T, Shibuya H.. IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling. J Biol Chem.. 2013.12; 288 (51): 36351-36360. ( PubMed, DOI )

  12. Goto T., Shimizu M., Sato A.(The first three authors contributed equally), Shibuya H.. WNK4 is an essential effector of anterior formation in FGF signaling. Genes Cells. 2013.06; 18 442-449. ( PubMed, DOI )

  13. Goto T., Sato A., Shimizu M., Adachi S., Satoh K., Iemura S., Natsume T., Shibuya H.. IQGAP1 functions as a modulator of Dishevelled Nuclear localization in Wnt signaling. PLoS One. 2013.04; 8 (4): e60865. ( PubMed, DOI )

  14. Goto T., Michiue T., Ito Y., Asashima M.. Characterization of CXC-type chemokine molecules in early Xenopus laevis development. Int. J. Dev. Biol.. 2013.03; 57 41-47. ( PubMed, DOI )

  15. Goto T., Asashima M.. Chemokine ligand Xenopus CXCLC (XCXCLC) regulates cell movements during early morphogenesis. Dev. Growth Differ.. 2011.12; 53 971-981.. ( PubMed, DOI )

  16. Goto T., Fukui A., Shibuya H., Keller R., Asashima M.. Xenopus furry contributes to release of microRNA gene silencing. Proc. Natl. Acad. Sci. U S A. 2010.11; 107 (45): 19344-19349. ( PubMed, DOI )

  17. Ogawa Y., Nonaka Y., Goto T., Ohnishi E., Hiramatsu T., Kii I., Yoshida M., Ikura T., Onogi H., Shibuya H., Hosoya T., Ito N., Hagiwara M.. Development of a novel selective inhibitor of the Downsyndrome-related kinase Dyrk1A. Nat. Commun.. 2010.10; ( PubMed, DOI )

  18. Goto T., Ohnishi E., Sato A.(The first three authors contributed equally), Kim M., Iemura S., Ishitani T., Natsume T., Ohnishi J.and Shibuya H.. Nemo-like kinase, an essential effector of anterior formation, functions downstream of p38 MAP kinase. Mol. Cell. Biol.. 2010.02; 30 675-683. ( PubMed, DOI )

  19. Watanabe Y., Itoh S., Goto T., Ohnishi E., Inamitsu M., Itoh F., Satoh K., Wiercinska E., Yang W., Shi L., Tanaka A., Nakano N., Mommaas A.M., Shibuya H., Dijke P., Kato M.. TMEPAI, a transmembrane TGF-β-inducible protein, sequesters Smad proteins from active participation in TGF-β signaling. Mol. Cell. 2010.01; 37 123-134. ( PubMed, DOI )

  20. Goto T., Keller R. and Asashima M.. Concentrations of TBP-type genes affect chordamesodermal gene expression. Int. J. Dev. Biol.. 2008.03; 52 371-375. ( PubMed, DOI )

  21. Kawasaki A., Kumasaka M., Satoh A., Suzuki M., Tamura K., Goto T., Asashima M., Yamamoto H.. Mitf contributes to melanosome distribution and melanophore dendricity. Pigment Cell Melanoma Res.. 2008.02; 21 56-62. ( PubMed, DOI )

  22. Goto T., Fukui A. (The first two authors contributed equally), Kitamoto J., Homma M., Asashima M.. SDF-1 alpha regulates mesendodermal cell migration during frog gastrulation. Biochem. Biophys. Res. Commun.. 2007.03; 354 422-427. ( PubMed, DOI )

  23. Suzawa K., Yukita A., Hayata T., Goto T., Danno H., Michiue T., Cho K.W., Asashima M.. Xenopus glucose transporter 1 (xGLUT1) is required for gastrulation movement in Xenopus laevis. Int. J. Dev. Biol.. 2007.03; 51 183-190. ( PubMed, DOI )

  24. Goto T., Davidson L., Asashima M., Keller R.. Planar cell polarity genes regulate polarized extracellular matrix deposition during frog gastrulation. Curr. Biol.. 2005.04; 15 787-793. ( PubMed, DOI )

  25. Goto T., Wallingford J.B.(The first two authors contributed equally), Keller R., Harland R.M.. Cloning and expression of Xenopus Prickle, an orthologue of a Drosophila planar cell polarity gene. Mech. Dev.. 2002.08; 116 183-186. ( PubMed )

  26. Goto T. (corresponding author), Keller R.. The planar cell polarity gene strabismus regulates convergence and extension and neural fold closure in Xenopus. Dev. Biol.. 2002.07; 247 165-181. ( PubMed, DOI )

  27. Goto T., Hasegawa K., Kinoshita T., Kubota H.Y.. A novel POZ/zinc finger protein, champignon, interferes with gastrulation movements in Xenopus. Dev. Dyn.. 2001.05; 221 14-25. ( PubMed, DOI )

  28. Noakes C.R., Goto T., Keller R., Periasamy A.. Does digital deconvolution improve two-photon microscopy in deep tissue imaging? Proc. SPIE. 2001.04; 4262 389-395. ( DOI )

  29. Goto T. (corresponding author), Katada T., Kinoshita T., Kubota H.Y.. Expression and characterization of Xenopus type I collagen alpha 1 (COL1A1) during embryonic development. Dev. Growth Differ.. 2000.06; 42 249-256. ( PubMed )

  30. 後藤利保. アフリカツメガエルの原腸陥入運動の分子機構に関する研究 2000.03; ( DOI )

  31. Goto T., Kinoshita T.. Maternal transcripts of mitotic checkpoint gene, Xbub3, are accumulated in the animal blastomeres of Xenopus early embryo. DNA Cell Biol.. 1999.03; 18 227-234. ( PubMed, DOI )

  32. Gotou T., Kinoshita K., Kinoshita T.. Calcium ionophore affecting the invagination in early Xenopus development. Kwansei Gakuin University Natural Sciences Reviews. 1997.10; 2 35-48.

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Conference Activities & Talks 【 display / non-display 】

  1. Kii U., Sumida Y., Goto T., Okuno Y., Nonaka Y., Abe M., Yoshida S., Kato T., Ikura T., Ito N., Shibuya H., Hosoya T., ○Hagiwara M.. A Novel type of kinase inhibitor that targets the folding intermediate of DYRK1A.. The 2nd Annual Conference of the International Chemical Biology Society 2013.10 Kyoto

  2. Goto, T.. IQGAP1 functions as a modulator of Dishevelled nuclear localization in Wnt signaling. 第８回研究所ネットワーク国際シンポジウム 2013.06.27 京都

  3. ○Fukui A., Goto T., Kitamoto J., Homma M., Asashima M.. SDF-1a regulates mesendodermal cell migration during gastrulation.. 11th International Xenopus Conference 2006.09.12 Kazusa, Japan

  4. ○Goto T., Fukui A., Keller R., Asashima M.. Xenopus furry (Xfurry) induces secondary axis.. 11th International Xenopus Conference 2006.09.12 Kazusa, Japan

  5. ○Goto T., Davidson L., Asashima M., Keller R.. Divergent functions of PCP genes in Xenopus gastrulation.. 10th International Xenopus Conference 2004.09.14 Woods Hole, USA

  6. ○Davidson L., Goto T., Asashima M., Keller R.. Matrix and Motility: Divergent functions of Xenopus Strabismus and Prickle during Gastrulation.. The Santa Cruz Conference on Developmental Biology 2004.08.05 Santa Cruz, California, USA

  7. ○Goto T., Davidson L., Asashima M., Keller R.. Two distinct roles of PCP genes in Xenopus gastrulation. ２１世紀COE、第１回国際シンポジウム 2003.11.13 東京

  8. ○Goto T., Hasegawa K., Katada T., Kinoshita T., Kubota H.Y., Keller R.E.. A novel POZ/zinc finger protein, champignon, interferes with gastrulation movements in Xenopus.. The 14th International Congress of Developmental Biology 2001.07.08 京都

  9. ○Kubota, H. Y., Goto, T., Kawasgima, T., and Yoshimoto, Y.. A transient rise in cytoplasmic free calcium lengthens the duration of the cell cycle in Xenopus egg.. The International Symposium: The frontiers of the biology of amphibia. 1999.03.22

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Campus class subject 【 display / non-display 】

  • Developmental and Regenerative Bioscience ，2021 - Now

  • Developmental and Regenerative Bioscience ，2021 - Now

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Performance of duties 【 display / non-display 】

  • ，2023.04 - Now

  • ，2023.04 - Now

  • ，2023.04 - Now

  • ，2019.04 - 2025.03

  • ，2019.04 - 2025.03

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