Personnel Information

写真a

SHIMIZU Shigeomi


Job title

Professor

Birth date

1958

Laboratory Address

Bunkyoku Yushima 1-5-45, 113-8510, Tokyo

Laboratory Phone number

+81-3-5803-4692

Laboratory Fax number

+81-3-5803-4821

Homepage URL

http://www.tmd.ac.jp/mri/pcb/index.html

Research Areas, Keywords

Cell Death, Apoptosis, Mitochondria, autophagy, necrosis, membrane permeability, Bcl-2

Graduating School 【 display / non-display

  • Osaka University, Faculty of Medicine, Medicine, 1984.03, Graduated

Degree 【 display / non-display

  • M.D., Ph.D., Osaka University

Campus Career 【 display / non-display

  • 1900.01
    -
    Now
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Pathological Cell Biology, Professor
  • 2010.09
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Pathological Cell Biology, Professor

External Career 【 display / non-display

  • 1983-1994 Surgeon, The First Department of Surgery, Osaka University Medical School Hospital, and its related hospitals.,
  • 1994-2000 Assistant Professor, Osaka University Graduate School of Medicine (Physiology and Genetics),
  • 2000-2006 Associate Professor, Osaka University Graduate School of Medicine (Genetics),
  • 2006- Professor, Tokyo Medical and Dental University,

Academic Activity 【 display / non-display

  • The Japanese Society of Cell Death Research
  • The Japanese Society of Mitochondria Research

Research Areas 【 display / non-display

  • General medical chemistry

  • Cell biology

 

Research Theme 【 display / non-display

  • Molecular Biology of Apoptosis and Autophagic Cell Death

  • Analysis of Alternative Macroautophagy

Published Papers & Misc 【 display / non-display

  • Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T, Komatsu M, Otsu K, Tsujimoto Y, Shimizu S. Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature. 2009.10; 461 (7264): 654-658. ( PubMed, DOI )

  • Shinya Honda, Satoko Arakawa, Yuya Nishida, Hirofumi Yamaguchi, Eiichi Ishii, Shigeomi Shimizu. . Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes. Nature Communications. 2014.06; 5 4004.

  • Satoru Torii, Hirofumi Yamaguchi, Akira Nakanishi, Satoko Arakawa, Shinya Honda, Kenta Moriwaki, Hiroyasu Nakano, Shigeomi Shimizu . Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy Nature Communications. 2020.03;

  • M. Narita, A.R.J. Young, S. Arakawa, S.A. Samarajiwa, T. Nakashima, S. Yoshida, S.K. Hong, L.S. Berry, S. Reichelt, M. Ferreira, S. Tavaré, K. Inoki, S. Shimizu, and M. Narita. . Spatial coupling of mTOR and autophagy augments secretory phenotypes Science. 2011.05; 332 966-970.

  • Hirofumi Yamaguchi, Shinya Honda, Satoru Torii, Kimiko Shimizu, Kaoru Kato, Koichi Miyake, Noriko Miyake, Nobuhiro Fujikake, Hajime Tajima Sakurai, Satoko Arakawa, Shigeomi Shimizu. Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration Nature Communications. 2020.08; press

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Books etc 【 display / non-display

  • shigeomi shimizu. cell death. 2017.12 autophagic cell death

  • Shimizu S. Autophagic Cell Death and Cancer Chemotherapeutics. . Springer, Innovative Medicine : Basic Research and Development

Conference Activities & Talks 【 display / non-display

  • Shimizu S. Mitophagy and alternative autophagy. The 13th Conference of Asian Society for Mitochondrial Reseach and Medicine 2016.10.31 Shinagawa

  • shimizu s. Macroautophagy mediates elimination of mitochondria from embryonic reticulocytes. 第78回日本血液学会 2016.10.13 yokohama

  • Shimizu S. Alterntive Autophagy is Essential for Neuronal Cell Maintenance. Brain Protein Aiging and Dementia Contorol International Workshop 2016.09.09 Nagoya

  • Shimizu S. Identification of natural puroduct against fatty liver disease based on the induction of alternative autophagy. ICNIM2016 2016.07.15 Sapporo

  • Shimizu S. Physiological Role of Atg5-independent macroautophagy (Shimizu S). The 16th Northeastern Asian Symposium. 2014.12.19 Busan Korea

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