Personnel Information

写真a

SHIMIZU Shigeomi


Job title

Professor

Birth date

1958

Laboratory Address

Bunkyoku Yushima 1-5-45, 113-8510, Tokyo

Laboratory Phone number

+81-3-5803-4692

Laboratory Fax number

+81-3-5803-4821

Homepage URL

http://www.tmd.ac.jp/mri/pcb/index.html

Research Areas, Keywords

Cell Death, Apoptosis, Mitochondria, autophagy, necrosis, membrane permeability, Bcl-2

Graduating School 【 display / non-display

  • Osaka University, Faculty of Medicine, Medicine, 1984.03, Graduated

Degree 【 display / non-display

  • M.D., Ph.D., Osaka University

Campus Career 【 display / non-display

  • 1900.01
    -
    2022.04
    Tokyo Medical and Dental University, Medical Research Institute, Pathophysiology, Pathological Cell Biology, Professor
  • 2010.09
    -
    Now
    Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Medical and Dental Sciences, Bio-Environmental Response, Pathological Cell Biology, Professor
  • 2022.05
    -
    2024.03
    Tokyo Medical and Dental University, Medical Research Institute, Division of Advanced Pathophysiological Science, Department of Pathological Cell Biology, Professor
  • 2024.04
    -
    Now
    Tokyo Medical and Dental University, TMDU Advanced Research Institute (TMDU-ARIS), -, -, Professor

External Career 【 display / non-display

  • 1983-1994 Surgeon, The First Department of Surgery, Osaka University Medical School Hospital, and its related hospitals.,
  • 1994-2000 Assistant Professor, Osaka University Graduate School of Medicine (Physiology and Genetics),
  • 2000-2006 Associate Professor, Osaka University Graduate School of Medicine (Genetics),
  • 2006- Professor, Tokyo Medical and Dental University,

Academic Activity 【 display / non-display

  • The Japanese Society of Cell Death Research
  • The Japanese Society of Mitochondria Research

Research Areas 【 display / non-display

  • Medical biochemistry

  • Cell biology

 

Research Theme 【 display / non-display

  • Molecular Biology of Apoptosis and Autophagic Cell Death

  • Analysis of Alternative Macroautophagy

Published Papers & Misc 【 display / non-display

  1. Nishida Y, Arakawa S, Fujitani K, Yamaguchi H, Mizuta T, Kanaseki T, Komatsu M, Otsu K, Tsujimoto Y, Shimizu S. Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature. 2009.10; 461 (7264): 654-658. ( PubMed, DOI )

  2. Shinya Honda, Satoko Arakawa, Yuya Nishida, Hirofumi Yamaguchi, Eiichi Ishii, Shigeomi Shimizu. . Ulk1-mediated Atg5-independent macroautophagy mediates elimination of mitochondria from embryonic reticulocytes. Nature Communications. 2014.06; 5 4004.

  3. Satoru Torii, Hirofumi Yamaguchi, Akira Nakanishi, Satoko Arakawa, Shinya Honda, Kenta Moriwaki, Hiroyasu Nakano, Shigeomi Shimizu . Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy Nature Communications. 2020.03;

  4. M. Narita, A.R.J. Young, S. Arakawa, S.A. Samarajiwa, T. Nakashima, S. Yoshida, S.K. Hong, L.S. Berry, S. Reichelt, M. Ferreira, S. Tavaré, K. Inoki, S. Shimizu, and M. Narita. . Spatial coupling of mTOR and autophagy augments secretory phenotypes Science. 2011.05; 332 966-970.

  5. Hirofumi Yamaguchi, Shinya Honda, Satoru Torii, Kimiko Shimizu, Kaoru Kato, Koichi Miyake, Noriko Miyake, Nobuhiro Fujikake, Hajime Tajima Sakurai, Satoko Arakawa, Shigeomi Shimizu. Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration Nature Communications. 2020.08; press

  6. Hirofumi Yamaguchi, Satoko Arakawa, Toku Kanaseki, Takeshi Miyatsuka, Yoshio Fujitani, Hirotaka Watada, Yoshihide Tsujimoto, Shigeomi Shimizu. Golgi membrane-associated degradation pathway in yeast and mammals. EMBO J.. 2016.09; 35 (18): 1991-2007. ( PubMed, DOI )

  7. Shinya Honda, Satoko Arakawa, Hirofumi Yamaguchi, Satoru Torii, Hajime Tajima Sakurai, Masatsune Tsujioka, Michiko Murohashi, Shigeomi Shimizu. Association Between Atg5-independent Alternative Autophagy and Neurodegenerative Diseases. J. Mol. Biol.. 2020.01; ( PubMed, DOI )

  8. Shigeomi Shimizu. Organelle zones in mitochondria. J. Biochem.. 2019.02; 165 (2): 101-107. ( PubMed, DOI )

  9. Tatsuya Hasegawa, Saori Noguchi, Masaya Nakashima, Masashi Miyai, Makiko Goto, Yuko Matsumoto, Satoru Torii, Shinya Honda, Shigeomi Shimizu. Alternative autophagy dampens UVB-induced NLRP3 inflammasome activation in human keratinocytes. J Biol Chem. 2024.03; 107173. ( PubMed, DOI )

  10. Di Wang, Shinya Honda, Min Kyoung Shin, Kei Watase, Hidehiro Mizusawa, Kinya Ishikawa, Shigeomi Shimizu. Subcellular localization and ER-mediated cytotoxic function of α1A and α1ACT in spinocerebellar ataxia type 6. Biochem Biophys Res Commun. 2024.02; 695 149481. ( PubMed, DOI )

  11. Tomoyo Yoshida, Tadashi Yokoi, Taku Tanaka, Emiko Matsuzaka, Yuki Saida, Sachiko Nishina, Shuji Takada, Shigeomi Shimizu, Noriyuki Azuma. Modeling of Retina and Optic Nerve Ischemia-Reperfusion Injury through Hypoxia-Reoxygenation in Human Induced Pluripotent Stem Cell-Derived Retinal Ganglion Cells. Cells. 2024.01; 13 (2): ( PubMed, DOI )

  12. Shichen Chang, Satoru Torii, Jun Inamo, Kinya Ishikawa, Yuta Kochi, Shigeomi Shimizu. Uncovering the Localization and Function of a Novel Read-Through Transcript ' TOMM40-APOE' Cells. 2023.12; 13 (1): ( PubMed, DOI )

  13. Kenichi Asano, Kenta Kikuchi, Miki Takehara, Manami Ogasawara, Yuki Yoshioka, Kie Ohnishi, Ayaka Iwata, Shigeomi Shimizu, Masato Tanaka. Identification of small compounds that inhibit multiple myeloma proliferation by targeting c-Maf transcriptional activity. Biochem Biophys Res Commun. 2023.12; 684 149135. ( PubMed, DOI )

  14. Hajime Tajima Sakurai, Satoko Arakawa, Hirofumi Yamaguchi, Satoru Torii, Shinya Honda, Shigeomi Shimizu. An Overview of Golgi Membrane-Associated Degradation (GOMED) and Its Detection Methods. Cells. 2023.12; 12 (24): ( PubMed, DOI )

  15. Sally Mehanna, Satoko Arakawa, Mai Imasaka, Wenting Chen, Yuto Nakanishi, Hiroshi Nishiura, Shigeomi Shimizu, Masaki Ohmuraya. Beclin1 is essential for the pancreas development. Dev Biol. 2023.09; ( PubMed, DOI )

  16. Satoru Torii, Satoko Arakawa, Shigeto Sato, Kei-Ichi Ishikawa, Daisuke Taniguchi, Hajime Tajima Sakurai, Shinya Honda, Yuuichi Hiraoka, Masaya Ono, Wado Akamatsu, Nobutaka Hattori, Shigeomi Shimizu. Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2. EMBO Mol Med. 2023.08; e17451. ( PubMed, DOI )

  17. Ryota Kawahara, Tomoko Usami, Satoko Arakawa, Hiroki Kamo, Takehiro Suzuki, Ryosuke Komatsu, Hiroyuki Hara, Yuki Niwa, Erina Shimizu, Naoshi Dohmae, Shigeomi Shimizu, Siro Simizu. Biogenesis of fibrils requires C-mannosylation of PMEL. FEBS J. 2023.08; ( PubMed, DOI )

  18. Hajime Tajima Sakurai, Hidefumi Iwashita, Satoko Arakawa, Alifu Yikelamu, Mizuki Kusaba, Satoshi Kofuji, Hiroshi Nishina, Munetaka Ishiyama, Yuichiro Ueno, Shigeomi Shimizu. Development of small fluorescent probes for the analysis of autophagy kinetics. iScience. 2023.07; 26 (7): 107218. ( PubMed, DOI )

  19. Yumiko Watanabe-Yasuoka, Ayako Gotou, Shigeomi Shimizu, Toshihiro Sashihara. OLL2712 Induces Autophagy via MYD88 and Strengthens Tight Junction Integrity to Promote the Barrier Function in Intestinal Epithelial Cells. Nutrients. 2023.06; 15 (12): ( PubMed, DOI )

  20. Masatsune Tsujioka, Keisuke Miyazawa, Masaki Ohmuraya, Yoichi Nibe, Tetsuya Shirokawa, Haruko Hayasaka, Tsunekazu Mizushima, Takeshi Fukuma, Shigeomi Shimizu. Identification of a novel type of focal adhesion remodelling via FAK/FRNK replacement, and its contribution to cancer progression. Cell Death Dis. 2023.04; 14 (4): 256. ( PubMed, DOI )

  21. TATSUYA IWAMOTO, SHIGEOMI SHIMIZU, HAJIME TAJIMA-SAKURAI, HIROFUMI YAMAGUCHI, YUYA NISHIDA, SATOKO ARAKAWA, HIROTAKA WATADA . Inhibition of Insulin Secretion Induces Golgi Morphological Changes Juntendo medical Journal. 2023.02; 69 (1): 42-49. ( PubMed, DOI )

  22. Tomoki Yanagi, Hiroaki Kikuchi, Koichiro Susa, Naohiro Takahashi, Hiroki Bamba, Takefumi Suzuki, Yuta Nakano, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Shintaro Mandai, Takayasu Mori, Koh Takeuchi, Shinya Honda, Satoru Torii, Shigeomi Shimizu, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara. Absence of ULK1 decreases AMPK activity in the kidney, leading to chronic kidney disease progression. Genes Cells. 2023.01; 28 (1): 5-14. ( PubMed, DOI )

  23. Hajime Tajima Sakurai, Satoko Arakawa, Saori Noguchi, Shigeomi Shimizu. FLIP-based autophagy-detecting technique reveals closed autophagic compartments. Sci Rep. 2022.12; 12 (1): 22452. ( PubMed, DOI )

  24. Hiroki Matsuda, Yoichi Nibe-Shirakihara, Akiko Tamura, Emi Aonuma, Satoko Arakawa, Kana Otsubo, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Shigeomi Shimizu, Averil Ma, Mamoru Watanabe, Motohiro Uo, Ryuichi Okamoto, Shigeru Oshima. Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice. Biochem Biophys Res Commun. 2022.02; 592 74-80. ( PubMed, DOI )

  25. Saori Noguchi, Shigeomi Shimizu. Molecular mechanisms and biological roles of GOMED FEBS Journal. 2021.11; ( DOI )

  26. Takuto Tokuhiro, Akane Ishikawa, Haruka Sato, Shunya Takita, Ayuri Yoshikawa, Ryoko Anzai, Shinichi Sato, Ryohei Aoyagi, Makoto Arita, Yasuaki Aratani, Shigeomi Shimizu, Masato Tanaka, Satoshi Yotsumoto. Oxidized phospholipids and neutrophil elastase coordinately play critical roles in NET formation Frontiers in Cell and Developmental Biology. 2021.09; ( DOI )

  27. Satoko Nakano, Yasuhiro Tomaru, Toshiaki Kubota, Hiroshi Takase, Manabu Mochizuki, Norio Shimizu, Sunao Sugita, . Multiplex Solid-Phase Real-Time Polymerase Chain Reaction without DNA Extraction: A Rapid Intraoperative Diagnosis Using Microvolumes. Ophthalmology. 2021.05; 128 (5): 729-739. ( PubMed, DOI )

  28. Shigeto Sato, Sachiko Noda, Satoru Torii, Taku Amo, Aya Ikeda, Manabu Funayama, Junji Yamaguchi, Takahiro Fukuda, Hiromi Kondo, Norihiro Tada, Satoko Arakawa, Masahiko Watanabe, Yasuo Uchiyama, Shigeomi Shimizu, Nobutaka Hattori. Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice. Hum Mol Genet. 2021.04; 30 (6): 443-453. ( PubMed, DOI )

  29. Mayumi Yoshimori, Haruna Shibayama, Ken-Ichi Imadome, Fuyuko Kawano, Ayaka Ohashi, Miwako Nishio, Norio Shimizu, Morito Kurata, Shigeyoshi Fujiwara, Ayako Arai. Antineoplastic and anti-inflammatory effects of bortezomib on systemic chronic active EBV infection. Blood Adv. 2021.04; 5 (7): 1805-1815. ( PubMed, DOI )

  30. Torii Satoru, Honda Shinya, Murohashi Michiko, Yamaguchi Hirofumi, Shimizu Shigeomi. Autophagy involvement in oncogenesis CANCER SCIENCE. 2020.11; 111 (11): 3993-3999. ( DOI )

  31. Torii Satoru, Honda Shinya, Murohashi Michiko, Yamaguchi Hirofumi, Shimizu Shigeomi. Autophagy involvement in oncogenesis(和訳中) Cancer Science. 2020.11; 111 (11): 3993-3999. ( ichushi )

  32. Torii Satoru, Shimizu Shigeomi. Involvement of phosphorylation of ULK1 in alternative autophagy AUTOPHAGY. 2020.08; 16 (8): 1532-1533. ( DOI )

  33. Yasueda Asuka, Kayama Hisako, Murohashi Michiko, Nishimura Junichi, Wakame Koji, Komatsu Ken-ichi, Ogino Takayuki, Miyoshi Norikatsu, Takahashi Hidekazu, Uemura Mamoru, Matsuda Chu, Kitagawa Toru, Takeda Kiyoshi, Ito Toshinori, Doki Yuichiro, Eguchi Hidetoshi, Shimizu Shigeomi, Mizushima Tsunekazu. Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages SCIENTIFIC REPORTS. 2020.06; 10 (1): ( DOI )

  34. Torii Satoru, Yamaguchi Hirofumi, Nakanishi Akira, Arakawa Satoko, Honda Shinya, Moriwaki Kenta, Nakano Hiroyasu, Shimizu Shigeomi. Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy NATURE COMMUNICATIONS. 2020.04; 11 (1): ( DOI )

  35. Hironori Kato, Kohki Okabe, Masato Miyake, Kazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, Masaya Ono, Yusuke Saito, Takashi Sugiyama, Takashi Funatsu, Katsuaki Sato, Shigeomi Shimizu, Seiichi Oyadomari, Hidenori Ichijo, Hisae Kadowaki, Hideki Nishitoh. ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue. Life Sci Alliance. 2020.03; 3 (3): ( PubMed, DOI )

  36. Satoru Torii, Shuya Kasai, Tatsushi Yoshida, Ken-Ichi Yasumoto, Shigeomi Shimizu. Mitochondrial E3 Ubiquitin Ligase Parkin: Relationships with Other Causal Proteins in Familial Parkinson's Disease and Its Substrate-Involved Mouse Experimental Models. Int J Mol Sci. 2020.02; 21 (4): ( PubMed, DOI )

  37. Yuji Kato, Satoko Arakawa, Kazue Terasawa, Jin-Ichi Inokuchi, Takanori Iwata, Shigeomi Shimizu, Tetsuro Watabe, Miki Hara-Yokoyama. The ceramide analogue N-(1-hydroxy-3-morpholino-1-phenylpropan-2-yl)decanamide induces large lipid droplet accumulation and highlights the effect of LAMP-2 deficiency on lipid droplet degradation. Bioorg. Med. Chem. Lett.. 2020.02; 30 (3): 126891. ( PubMed, DOI )

  38. 清水 重臣, 山口 啓史, 桜井 一, 荒川 聡子. ゴルジ体の機能と構造(Molecular mechanisms and physiological roles of alternative autophagy) 日本生化学会大会プログラム・講演要旨集. 2019.09; 92回 [3S12m-05]. ( ichushi )

  39. Muraoka Naoto, Nara Kaori, Tamura Fumiya, Kojima Hidenori, Yamakawa Hiroyuki, Sadahiro Taketaro, Miyamoto Kazutaka, Isomi Mari, Haginiwa Sho, Tani Hidenori, Kurotsu Shota, Osakabe Rina, Torii Satoru, Shimizu Shigeomi, Okano Hideyuki, Sugimoto Yukihiko, Fukuda Keiichi, Ieda Masaki. Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming NATURE COMMUNICATIONS. 2019.02; 10 ( DOI )

  40. Sugimoto Y, Murohashi M, Arakawa S, Honda S, Shimizu S. Prediction of intracellular targets of a small compound by analyzing peptides presented on MHC class I. Biochemical and biophysical research communications. 2019.01; 508 (2): 480-486. ( PubMed, DOI )

  41. Noguchi Saori, Honda Shinya, Saitoh Tatsuya, Matsumura Hiroyuki, Nishimura Emi, Akira Shizuo, Shimizu Shigeomi. Beclin 1 regulates recycling endosome and is required for skin development in mice COMMUNICATIONS BIOLOGY. 2019.01; 2 ( DOI )

  42. shigeomi shimizu. Organelle zones in mitochondria The Journal of Biochemistry. 2018.12;

  43. Tsurusaki Shinya, Matsuda Michitaka, Shimizu Shigeomi, Nakano Hiroyasu, Miyajima Atsushi, Tanaka Minoru. Elucidation of the Type of Cell Death at the Onset of Non-Alcoholic Steatohepatitis (NASH) HEPATOLOGY. 2018.10; 68 1023A-1024A.

  44. Nobuhiro Fujikake, Minkyoung Shin, Shigeomi Shimizu. Association Between Autophagy and Neurodegenerative Diseases. Front Neurosci. 2018.09; 12 255. ( PubMed, DOI )

  45. 渡辺 雄一郎, 本田 真也, 小西 昭充, 田邉 稔, 田中 真二, 清水 重臣. オートファジーはCep63を介して中心体数を制御する(Autophagy controls centrosome number by degrading Cep63) 日本癌学会総会記事. 2018.09; 77回 63. ( ichushi )

  46. 清水 重臣, 成田 匡司, 荒川 聡子. がんと細胞老化シグナル(Cancer and cellular senescence signaling Relationship between autophagy and cellular senescence Relationship between autophagy and cellular senescence) 日本癌学会総会記事. 2018.09; 77回 1120. ( ichushi )

  47. Meruna Nagata, Satoko Arakawa, Hirofumi Yamaguchi, Satoru Torii, Hazuki Endo, Masatsune Tsujioka, Shinya Honda, Yuya Nishida, Akimitsu Konishi, Shigeomi Shimizu. Dram1 regulates DNA damage-induced alternative autophagy Cell Stress. 2018.03; 2 (3): 55-65. ( DOI )

  48. Tomokazu Yamaguchi, Takashi Suzuki, Teruki Sato, Akinori Takahashi, Hiroyuki Watanabe, Ayumi Kadowaki, Miyuki Natsui, Hideaki Inagaki, Satoko Arakawa, Shinji Nakaoka, Yukio Koizumi, Shinsuke Seki, Shungo Adachi, Akira Fukao, Toshinobu Fujiwara, Tohru Natsume, Akinori Kimura, Masaaki Komatsu, Shigeomi Shimizu, Hiroshi Ito, Yutaka Suzuki, Josef M Penninger, Tadashi Yamamoto, Yumiko Imai, Keiji Kuba. The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci Signal. 2018.02; 11 (516): ( PubMed, DOI )

  49. Hidefumi Iwashita, Hajime Tajima Sakurai, Noriyoshi Nagahora, Munetaka Ishiyama, Kosei Shioji, Kazumi Sasamoto, Kentaro Okuma, Shigeomi Shimizu, Yuichiro Ueno. Small fluorescent molecules for monitoring autophagic flux. FEBS Lett.. 2018.02; 592 (4): 559-567. ( PubMed, DOI )

  50. Shigeomi Shimizu. Biological Roles of Alternative Autophagy. Mol. Cells. 2018.01; 41 (1): 50-54. ( PubMed, DOI )

  51. Kohno Takashi, Shimizu Shigeomi. New therapeutic ways for new precision cancer medicine: Vulnerability of cancer cells CANCER SCIENCE. 2018.01; 109 942.

  52. 本田 真也, 清水 重臣. オートファジーは中心体数を制御することで腫瘍形成を抑制する 生命科学系学会合同年次大会. 2017.12; 2017年度 [1P-1001]. ( ichushi )

  53. Satoshi Yotsumoto, Yuito Muroi, Tatsuya Chiba, Rio Ohmura, Maki Yoneyama, Megumi Magarisawa, Kosuke Dodo, Naoki Terayama, Mikiko Sodeoka, Ryohei Aoyagi, Makoto Arita, Satoko Arakawa, Shigeomi Shimizu, Masato Tanaka. Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation. Sci Rep. 2017.11; 7 (1): 16026. ( PubMed, DOI )

  54. Hidefumi Iwashita, Satoru Torii, Noriyoshi Nagahora, Munetaka Ishiyama, Kosei Shioji, Kazumi Sasamoto, Shigeomi Shimizu, Kentaro Okuma. Live Cell Imaging of Mitochondrial Autophagy with a Novel Fluorescent Small Molecule. ACS Chem. Biol.. 2017.10; 12 (10): 2546-2551. ( PubMed, DOI )

  55. Shigeomi Shimizu. Biological roles of alternative autophagy Molecules and Cells. 2017.10;

  56. Kazuya Kanemoto, Yasuyuki Sugimura, Shigeomi Shimizu, Suguru Yoshida, Takamitsu Hosoya. Rhodium-catalyzed odorless synthesis of diaryl sulfides from borylarenes and S-aryl thiosulfonates. Chem. Commun. (Camb.). 2017.09; 53 (77): 10640-10643. ( PubMed, DOI )

  57. Satoko Arakawa, Shinya Honda, Hirofumi Yamaguchi, Shigeomi Shimizu. Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy Proceedings of the Japan Academy, Series B. 2017.09;

  58. Jumpei Asano, Taku Sato, Shizuko Ichinose, Mihoko Kajita, Nobuyuki Onai, Shigeomi Shimizu, and Toshiaki Ohteki . Intrinsic autophagy is required for the maintenance of intestinal stem cells and for irradiation-induced intestinal regeneration Cell Reports. 2017.09;

  59. Hidefumi Iwashita , Satoru Torii, Noriyoshi Nagahora, Munetaka Ishiyama, Kosei Shioji, Kazumi Sasamoto, Shigeomi Shimizu, and Kentaro Okuma. Live Cell Imaging of Mitochondrial Autophagy with a Novel Fluorescent Small Molecule ACS Chem. Biol.. 2017.09;

  60. 清水 重臣. がん個別化医療の革新を目指す新規治療戦略 がんの脆弱性 オートファジー細胞死を誘導する新規抗がん剤の開発 日本癌学会総会記事. 2017.09; 76回 S18-1. ( ichushi )

  61. Jumpei Asano, Taku Sato, Shizuko Ichinose, Mihoko Kajita, Nobuyuki Onai, Shigeomi Shimizu, Toshiaki Ohteki. Intrinsic Autophagy Is Required for the Maintenance of Intestinal Stem Cells and for Irradiation-Induced Intestinal Regeneration. Cell Rep. 2017.08; 20 (5): 1050-1060. ( PubMed, DOI )

  62. Satoko Arakawa, Shinya Honda, Hirofumi Yamaguchi, Shigeomi Shimizu. Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy. Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci.. 2017.06; 93 (6): 378-385. ( PubMed, DOI )

  63. Satoko Arakawa, Masatsune Tsujioka, Tatsushi Yoshida, Hajime Tajima-Sakurai, Yuya Nishida, Yosuke Matsuoka, Ikuyo Yoshino, Yoshihide Tsujimoto, Shigeomi Shimizu. Role of Atg5-dependent cell death in the embryonic development of Bax/Bak double-knockout mice. Cell Death Differ.. 2017.06; ( PubMed, DOI )

  64. Arakawa Satoko, Honda Shinya, Yamaguchi Hirofumi, Shimizu Shigeomi. Atg5/Atg7非依存的代替オートファジーの分子機序と生理的役割(Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy) Proceedings of the Japan Academy Series B, Physical and Biological Sciences. 2017.06; 93 (6): 378-384. ( ichushi )

  65. Satoko Arakawa, Shinya Honda, Satoru Torii, Masatsune Tsujioka, Shigeomi Shimizu. Monitoring of Atg5-Independent Mitophagy. Methods Mol. Biol.. 2017.04; ( PubMed, DOI )

  66. Tatsuya Kozaki, Jun Komano, Daiki Kanbayashi, Michihiro Takahama, Takuma Misawa, Takashi Satoh, Osamu Takeuchi, Taro Kawai, Shigeomi Shimizu, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh. Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response. Proc. Natl. Acad. Sci. U.S.A.. 2017.03; 114 (10): 2681-2686. ( PubMed, DOI )

  67. Shinya Honda, Shigeomi Shimizu. Autophagy controls centrosome number. Oncotarget. 2017.02; 8 (9): 14277-14278. ( PubMed, DOI )

  68. Arakawa S, Honda S, Yamaguchi H, Shimizu S.. Molecular mechanisms and physiological roles of Atg5/Atg7-independent alternative autophagy. Proceedinds of the Japan Academy,Series B.. 2017;

  69. Satoru Torii, Tatsushi Yoshida, Satoko Arakawa, Shinya Honda, Akira Nakanishi, Shigeomi Shimizu. Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress-induced autophagy. EMBO Rep.. 2016.11; 17 (11): 1552-1564. ( PubMed, DOI )

  70. Yuichiro Watanabe, Shinya Honda, Akimitsu Konishi, Satoko Arakawa, Michiko Murohashi, Hirofumi Yamaguchi, Satoru Torii, Minoru Tanabe, Shinji Tanaka, Eiji Warabi, Shigeomi Shimizu. Autophagy controls centrosome number by degrading Cep63. Nat Commun. 2016.11; 7 13508. ( PubMed, DOI )

  71. Akimitsu Konishi, Takashi Izumi, Shigeomi Shimizu. TRF2 Protein Interacts with Core Histones to Stabilize Chromosome Ends. J. Biol. Chem.. 2016.09; 291 (39): 20798-20810. ( PubMed, DOI )

  72. Uchiyama H, Uehara K, Nagashima T, Nakata A, Sato K, Mihara Y, Komatsu KI, Takanari J, Shimizu S, Wakame K. Global Liver Gene Expression Analysis on a Murine Metabolic Syndrome Model Treated by Low-molecular-weight Lychee Fruit Polyphenol (Oligonol®). Anticancer research. 2016.07; 36 (7): 3705-13. ( PubMed )

  73. Tatsushi Yoshida, Masatsune Tsujioka, Shinya Honda, Masato Tanaka, Shigeomi Shimizu. Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF. Oncotarget. 2016.06; 7 (23): 34420-34429. ( PubMed, DOI )

  74. Yusuke Nasu, Alexander Benke, Satoko Arakawa, Go J Yoshida, Genki Kawamura, Suliana Manley, Shigeomi Shimizu, Takeaki Ozawa. In Situ Characterization of Bak Clusters Responsible for Cell Death Using Single Molecule Localization Microscopy. Sci Rep. 2016.06; 6 27505. ( PubMed, DOI )

  75. Uchiyama H, Uehara K, Nagashima T, Nakata A, Sato K, Mihara Y, Komatsu K, Takanari J, Shimizu S, Wakame K.. Global Liver Gene Expression Analysisi on a Murine Metabolic Syndrome Model Treated by Low-molecular-weight Lychee Fruit Polyphenol. Anticancer Research.. 2016; 36 (7): 3705-3713.

  76. Shigeomi Shimizu. Autophagic Cell Death and Cancer Chemotherapeutics Innovative Medicine : Basic Research and Development. 2015.09; 219-226.

  77. Ito H, Fujita K, Tagawa K, Chen X, Homma H, Sasabe T, Shimizu J, Shimizu S, Tamura T, Muramatsu S, Okazawa H. HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice. EMBO molecular medicine. 2015.01; 7 (1): 78-101. ( PubMed, DOI )

  78. Matsuda G, Imadome K, Kawano F, Mochizuki M, Ochiai N, Morio T, Shimizu N, Fujiwara S. . Cellular immunotherapy with ex vivo expanded cord blood T cells in a humanized mouse model of EBV-associated lymphoproliferative disease. Immunotherapy. Immunotherapy. . 2015; 7 335-341.

  79. Yun-Wen Chen, Tianhuan Guo, Lijun Shen, Kai-Yau Wong, Qian Tao, William W. L. Choi, Rex K. H. Au-Yeung, Yuen-Piu Chan, Michelle L. Y. Wong, Johnny C. O. Tang, Wei-Ping Liu, Gan-Di Li, Norio Shimizu, Florence Loong, Eric Tse, Yok-Lam Kwong and Gopesh Srivastava. . Receptor-type tyrosine-protein phosphatase k directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma. Blood . 2015; 125 1589-1600.

  80. Inazawa N, Hori T, Hatakeyama N, Yamamoto M, Yoto Y, Nojima M, Suzuki N, Shimizu N, Tsutsumi H. Large-scale multiplex polymerase chain reaction assay for diagnosis of viral reactivations after allogeneic hematopoietic stem cell transplantation. J Med Virol. . 2015; 87 1427-1435.

  81. Inazawa N, Hori T, Yamamoto M, Hatakeyama N, Yoto Y, Nojima M, Yasui H, Suzuki N, Shimizu N, Tsutsumi H. . HHV-6 encephalitis may complicate the early phase after allogeneic hematopoietic stem cell transplantation: Detection by qualitative multiplex PCR and subsequent quantitative real-time PCR. J Med Virol. 2015;

  82. Yoshimori M, Takada H, Imadome K, Kurata M, Yamamoto K, Koyama T, Shimizu N, Fujiwara S, Miura O, Arai A. P-glycoprotein is expressed and causes resistance to chemotherapy in EBV-positive T-cell lymphoproliferative diseases. Cancer Med. . 2015; 4 1494-1504.

  83. S. Yoshida, T. Yano, Y. Misawa, Y. Sugimura, K. Igawa, S. Shimizu, K. Tomooka, T. Hosoya. . Direct Thioamination of Arynes via Reaction with Sulfilimines and Migratory N-Arylation. J. Am. Chem. Soc. . 2015; 137 14071-14074.

  84. S. Arakawa, I. Nakanomyo, Y. Kudo-Sakamoto, H. Akazawa, I. Komuro, S. Shimizu.. Identification of a novel compound that inhibits both mitochondria-mediated necrosis and apoptosis. Biochem. Biophys. Res. Commun. 2015; 467 1006-1011.

  85. S. Yoshida, Y. Sugimura, Y. Hazama, Y. Nishiyama, T. Yano, S. Shimizu, T.Hosoya. . A mild and facile synthesis of aryl and alkenyl sulfides via copper-catalyzed deborylthiolation of organoborons with thiosulfonates. Chemical Commun. 2015; 51 16613-16616.

  86. Shigeomi Shimizu, Shinya Honda, Satoko Arakawa, Hirofumi Yamaguchi. Alternative macroautophagy and mitophagy. Int. J. Biochem. Cell Biol.. 2014.05; 50 64-66. ( PubMed, DOI )

  87. S. Shimizu, S. Honda, S. Arakawa, H. Yamaguchi,. Alternative Macroautophagy and Mitophagy  Int. J. Biochem. Cell Biol. . 2014.03; 50 64-66.

  88. S. Shimizu, T. Yoshida, M. Tsujioka, S. Arakawa.. Autophagic Cell Death and Cancer. Int J Mol Sci.. 2014.02; 15 3145-3153.

  89. Juhász G, Puertollano R, Shimizu S, Vaccaro MI. Autophagy researchers. Autophagy. 2013.06; 9 (6): 815-8. ( PubMed, DOI )

  90. T. Mizushima, S. Arakawa, Y. Sanada, I. Yoshino, D. Miyazaki, H. Urushima, Y. Tsujimoto, T. Ito, S.Shimizu . Inhibition of epithelial cell death by Bcl-2 improved chronic colitis in IL10 KO mice American J Pathology. 2013.04; 183 1936-1944.

  91. I. Nakase, S. Okumura, S. Katayama, H. Hirose, S. Pujals, H. Yamaguchi, S. Arakawa, S. Shimizu, S. Futaki. Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine Chemical Communications. 2012.10; 48 11097-11099.

  92. Y. Miyaoka, K. Ebato, H. Kato, S. Arakawa, S. Shimizu, A. Miyajima. . Hypertrophy and unconventional cell division of hepatocytes underlie liver regeneration. Current Biology. 2012.09; 22 1166-1175.

  93. M. Fukamatsu, M. Ogawa, S. Arakawa, H. Ashida, M. Suzuki, M. Furuse, K. Nakayama, S. Shimizu, M. Kin, H. Mimuro, C. Sasakawa. . Shigella targets epithelial tricellular junctions to spread between cells via a noncanonical clathrin-dependent endocytic pathway. Cell Host Microbe.. 2012.09; 11 325-336.

  94. A. Konishi, S. Arakawa, Z. Yue, and S. Shimizu. . Involvement of Beclin 1 in the engulfment of apoptotic cells. J. Biol. Chem.. 2012.05; 287 13919-13929.

  95. Fukumatsu M, Ogawa M, Arakawa S, Suzuki M, Nakayama K, Shimizu S, Kim M, Mimuro H, Sasakawa C. Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cells. Cell host & microbe. 2012.04; 11 (4): 325-36. ( PubMed, DOI )

  96. Konishi A, Arakawa S, Yue Z, Shimizu S. Involvement of Beclin 1 in engulfment of apoptotic cells. The Journal of biological chemistry. 2012.04; 287 (17): 13919-29. ( PubMed, DOI )

  97. Y. Yoshioka, S. Shimizu, T. Ito, M. Taniguchi, M. Nomura, T. Nishida, Y. Sawa. . p53 Inhibits Vascular Endothelial Growth Factor Expression in Solid Tumor. J Surg Res. . 2012.03; 174 291-297.

  98. T. Yamasaki, H. Kawasaki, S. Arakawa, K. Shimizu, S. Shimizu, O. Reiner, H. Okano, S. Nishina, N. Azuma, J.M. Penninger, T. Katada and H Nishina. . Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex Journal of Neuroscience.. 2011.06; 31 16872-16883.

  99. H. Hikita, T. Takehara, T. Kodama, S. Shimizu, M. Shigekawa, A. Hosui, T. Miyagi, T. Tatsumi, H. Ishida, Li W, T. Kanto, N. Hiramatsu, S. Shimizu, Y. Tsujimoto, N. Hayashi.. Delayed-onset caspase-dependent massive hepatocyte apoptosis upon Fas activation in Bak/Bax-deficient mice Hepatology. 2011.03; 54 240-251.

  100. Kamiya K, Tsumoto K, Arakawa S, Shimizu S, Morita I, Yoshimura T, Akiyoshi K. Preparation of connexin43-integrated giant Liposomes by a baculovirus expression-liposome fusion method. Biotechnol Bioeng. 2010.12; 107 (5): 836-843. ( PubMed, DOI )

  101. Yoshida T, Mizuta T, Shimizu S. Neurodegeneration in mnd2 mutant mice is not prevented by parkin transgene. Biochem Biophys Res Commun. 2010.11; 402 (4): 676-679. ( PubMed, DOI )

  102. Nabeyama A, Kurita A, Asano K, Miyake Y, Yasuda T, Miura I, Nishitai G, Arakawa S, Shimizu S, Wakana S, Yoshida H, Tanaka M. xCT deficiency accelerates chemically induced tumorigenesis. Proc Natl Acad Sci USA. 2010.04; 107 (14): 6436-6441. ( PubMed, DOI )

  103. Shimizu S, Konishi A, Nishida Y, Mizuta T, Nishina H, Yamamoto A, Tsujimoto Y. Involvement of JNK in the regulation of autophagic cell death. Oncogene. 2010.04; 29 (14): 2070-2082. ( PubMed, DOI )

  104. Ideguchi K, Shimizu S, Okumura M, Tsujimoto Y. Cyclophilin D-dependent mitochondrial permeability transition is not involved in neurodegeneration in mnd2 mutant mice. Biochem Biophys Res Commun. 2010.03; 393 (2): 264-267. ( PubMed, DOI )

  105. Mouri A, Noda Y, Shimizu S, Tsujimoto Y, Nabeshima T. The role of cyclophilin D in learning and memory. Hippocampus. 2010.02; 20 (2): 293-304. ( PubMed, DOI )

  106. Shimizu S, Arakawa S, Nishida Y. Autophagy takes an alternative pathway. Autophagy. 2010.02; 6 (2): 290-291. ( PubMed )

  107. Yamagata H, Shimizu S, Nishida Y, Watanabe Y, Craigen WJ, Tsujimoto Y. Requirement of voltage-dependent anion channel 2 for pro-apoptotic activity of Bax. Oncogene. 2009.10; 28 (40): 3563-3572. ( PubMed, DOI )

  108. Shimada H, Hirai K, Simamura E, Hatta T, Iwakiri H, Mizuki K, Hatta T, Sawasaki T, Matsunaga S, Endo Y, Shimizu S. Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependent oxidoreductase. J Biol Chem. 2009.10; 284 (42): 28642-28649. ( PubMed, DOI )

  109. Kato M, Akao M, Matsumoto-Ida M, Makiyama T, Iguchi M, Takeda T, Shimizu S, Kita T. The targeting of cyclophilin D by RNAi as a novel cardioprotective therapy: evidence from two-photon imaging. Cardiovascular research. 2009.07; 83 (2): 335-44. ( PubMed, DOI )

  110. Young AR, Narita M, Ferreira M, Kirschner K, Sadaie M, Darot JF, Tavaré S, Arakawa S, Shimizu S, Watt FM, Narita M. Autophagy mediates the mitotic senescence transition. Genes Dev. 2009.04; 23 (7): 798-803. ( PubMed, DOI )

  111. Inagaki R, Tagawa K, Qi ML, Enokido Y, Ito H, Tamura T, Shimizu S, Oyanagi K, Arai N, Kanazawa I, Wanker EE, Okazawa H. Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease. The European journal of neuroscience. 2008.07; 28 (1): 30-40. ( PubMed, DOI )

  112. Kajitani K, Fujihashi M, Kobayashi Y, Shimizu S, Tsujimoto Y, Miki K. Crystal structure of human cyclophilin D in complex with its inhibitor, cyclosporin A at 0.96-A resolution. Proteins. 2008.03; 70 (4): 1635-1639. ( PubMed, DOI )

  113. Suzuki C, Isaka Y, Shimizu S, Tsujimoto Y, Takabatake Y, Ito T, Takahara S, Imai E. Bcl-2 protects tubular epithelial cells from ischemia reperfusion injury by inhibiting apoptosis. Cell Transplant. 2008; 17 (1-2): 223-229. ( PubMed )

  114. Mizuta T, Shimizu S, Matsuoka Y, Nakagawa T, Tsujimoto Y. A Bax/Bak-independent mechanism of cytochrome c release. J Biol Chem. 2007.06; 282 (22): 16623-16630. ( PubMed, DOI )

  115. Tsujimoto Y, Shimizu S. Role of the mitochondrial membrane permeability transition in cell death. Apoptosis. 2007.05; 12 (5): 835-840. ( PubMed, DOI )

  116. Simamura E, Hirai K, Shimada H, Koyama J, Niwa Y, Shimizu S. Furanonaphthoquinones cause apoptosis of cancer cells by inducing the production of reactive oxygen species by the mitochondrial voltage-dependent anion channel. Cancer Biol Ther. 2006.11; 5 (11): 1523-1529. ( PubMed )

  117. Ito K, Oji Y, Tatsumi N, Shimizu S, Kanai Y, Nakazawa T, Asada M, Jomgeow T, Aoyagi S, Nakano Y, Tamaki H, Sakaguchi N, Shirakata T, Nishida S, Kawakami M, Tsuboi A, Oka Y, Tsujimoto Y, Sugiyama H. Antiapoptotic function of 17AA(+)WT1 (Wilms' tumor gene) isoforms on the intrinsic apoptosis pathway. Oncogene. 2006.07; 25 (30): 4217-4229. ( PubMed, DOI )

  118. Tsujimoto Y, Nakagawa T, Shimizu S. Mitochondrial membrane permeability transition and cell death. Biochim Biophys Acta. 2006; 1757 (9-10): 1297-1300. ( PubMed, DOI )

  119. Tsujimoto Y, Shimizu S. Another way to die: autophagic programmed cell death. Cell Death Differ. 2005.11; 12 Suppl 2 1528-1534. ( PubMed, DOI )

  120. Elinder F, Akanda N, Tofighi R, Shimizu S, Tsujimoto Y, Orrenius S, Ceccatelli S. Opening of plasma membrane voltage-dependent anion channels (VDAC) precedes caspase activation in neuronal apoptosis induced by toxic stimuli. Cell Death Differ. 2005.08; 12 (8): 1134-1140. ( PubMed, DOI )

  121. Takahashi N, Kobayashi S, Kajino S, Imai K, Tomoda K, Shimizu S, Okamoto T. Inhibition of the 53BP2S-mediated apoptosis by nuclear factor kappaB and Bcl-2 family proteins. Genes to cells : devoted to molecular & cellular mechanisms. 2005.08; 10 (8): 803-11. ( PubMed, DOI )

  122. Chen C, Shimizu S, Tsujimoto Y, Motoyama N. Chk2 regulates transcription-independent p53-mediated apoptosis in response to DNA damage. Biochem Biophys Res Commun. 2005.07; 333 (2): 427-431. ( PubMed, DOI )

  123. Zhang L, Shimizu S, Tsujimoto Y. Two distinct Fas-activated signaling pathways revealed by an antitumor drug D609. Oncogene. 2005.04; 24 (18): 2954-2962. ( PubMed, DOI )

  124. Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H, Inohara H, Kubo T, Tsujimoto Y. Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature. 2005.03; 434 (7033): 652-658. ( PubMed, DOI )

  125. Ono M, Sawa Y, Ryugo M, Alechine AN, Shimizu S, Sugioka R, Tsujimoto Y, Matsuda H. BH4 peptide derivative from Bcl-xL attenuates ischemia/reperfusion injury thorough anti-apoptotic mechanism in rat hearts. Eur J Cardiothorac Surg. 2005.01; 27 (1): 117-121. ( PubMed, DOI )

  126. Sugioka R, Shimizu S, Tsujimoto Y. Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis. J Biol Chem. 2004.12; 279 (50): 52726-52734. ( PubMed, DOI )

  127. Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Thompson CB, Tsujimoto Y. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol. 2004.12; 6 (12): 1221-1228. ( PubMed, DOI )

  128. Zhang L, Shimizu S, Sakamaki K, Yonehara S, Tsujimoto Y. A caspase-8-independent signaling pathway activated by Fas ligation leads to exposure of the Bak N terminus. J Biol Chem. 2004.08; 279 (32): 33865-33874. ( PubMed, DOI )

  129. Tsuruta F, Sunayama J, Mori Y, Hattori S, Shimizu S, Tsujimoto Y, Yoshioka K, Masuyama N, Gotoh Y. JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J. 2004.04; 23 (8): 1889-1899. ( PubMed, DOI )

  130. Sugioka R, Shimizu S, Funatsu T, Tamagawa H, Sawa Y, Kawakami T, Tsujimoto Y. BH4-domain peptide from Bcl-xL exerts anti-apoptotic activity in vivo. Oncogene. 2003.11; 22 (52): 8432-8440. ( PubMed, DOI )

  131. Konishi A, Shimizu S, Hirota J, Takao T, Fan Y, Matsuoka Y, Zhang L, Yoneda Y, Fujii Y, Skoultchi AI, Tsujimoto Y. Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks. Cell. 2003.09; 114 (6): 673-688. ( PubMed )

  132. Nomura M, Shimizu S, Sugiyama T, Narita M, Ito T, Matsuda H, Tsujimoto Y. 14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax. J Biol Chem. 2003.01; 278 (3): 2058-2065. ( PubMed, DOI )

  133. Akao Y, Maruyama W, Shimizu S, Yi H, Nakagawa Y, Shamoto-Nagai M, Youdim MB, Tsujimoto Y, Naoi M. Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan. J Neurochem. 2002.08; 82 (4): 913-923. ( PubMed )

  134. Sugiyama T, Shimizu S, Matsuoka Y, Yoneda Y, Tsujimoto Y. Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim. Oncogene. 2002.07; 21 (32): 4944-4956. ( PubMed, DOI )

  135. Tsujimoto Y, Shimizu S. The voltage-dependent anion channel: an essential player in apoptosis. Biochimie. 2002; 84 (2-3): 187-193. ( PubMed )

  136. Shimizu S, Matsuoka Y, Shinohara Y, Yoneda Y, Tsujimoto Y. Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells. J Cell Biol. 2001.01; 152 (2): 237-250. ( PubMed )

  137. Tsujimoto Y, Shimizu S. VDAC regulation by the Bcl-2 family of proteins. Cell Death Differ. 2000.12; 7 (12): 1174-1181. ( PubMed, DOI )

  138. Kusano H, Shimizu S, Koya RC, Fujita H, Kamada S, Kuzumaki N, Tsujimoto Y. Human gelsolin prevents apoptosis by inhibiting apoptotic mitochondrial changes via closing VDAC. Oncogene. 2000.10; 19 (42): 4807-4814. ( PubMed, DOI )

  139. Shimizu S, Shinohara Y, Tsujimoto Y. Bax and Bcl-xL independently regulate apoptotic changes of yeast mitochondria that require VDAC but not adenine nucleotide translocator. Oncogene. 2000.09; 19 (38): 4309-4318. ( PubMed, DOI )

  140. Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y, Kuzumaki N. Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release. J Biol Chem. 2000.05; 275 (20): 15343-15349. ( PubMed )

  141. Shimizu S, Ide T, Yanagida T, Tsujimoto Y. Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c. J Biol Chem. 2000.04; 275 (16): 12321-12325. ( PubMed )

  142. Shimizu S, Konishi A, Kodama T, Tsujimoto Y. BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. Proc Natl Acad Sci USA. 2000.03; 97 (7): 3100-3105. ( PubMed )

  143. Tsujimoto Y, Shimizu S. Bcl-2 family: life-or-death switch. FEBS Lett. 2000.01; 466 (1): 6-10. ( PubMed )

  144. Shimizu S, Tsujimoto Y. Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity. Proc Natl Acad Sci USA. 2000.01; 97 (2): 577-582. ( PubMed )

  145. Nomura M, Shimizu S, Ito T, Narita M, Matsuda H, Tsujimoto Y. Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl-2. Cancer Res. 1999.11; 59 (21): 5542-5548. ( PubMed )

  146. Imazu T, Shimizu S, Tagami S, Matsushima M, Nakamura Y, Miki T, Okuyama A, Tsujimoto Y. Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability. Oncogene. 1999.08; 18 (32): 4523-4529. ( PubMed, DOI )

  147. Shimizu S, Narita M, Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature. 1999.06; 399 (6735): 483-487. ( PubMed, DOI )

  148. Eguchi Y, Srinivasan A, Tomaselli KJ, Shimizu S, Tsujimoto Y. ATP-dependent steps in apoptotic signal transduction. Cancer Res. 1999.05; 59 (9): 2174-2181. ( PubMed )

  149. Okuno S, Shimizu S, Ito T, Nomura M, Hamada E, Tsujimoto Y, Matsuda H. Bcl-2 prevents caspase-independent cell death. J Biol Chem. 1998.12; 273 (51): 34272-34277. ( PubMed )

  150. Narita M, Shimizu S, Ito T, Chittenden T, Lutz RJ, Matsuda H, Tsujimoto Y. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci USA. 1998.12; 95 (25): 14681-14686. ( PubMed )

  151. Tanabe H, Eguchi Y, Shimizu S, Martinou JC, Tsujimoto Y. Death-signalling cascade in mouse cerebellar granule neurons. Eur J Neurosci. 1998.04; 10 (4): 1403-1411. ( PubMed )

  152. Yoshimura S, Banno Y, Nakashima S, Takenaka K, Sakai H, Nishimura Y, Sakai N, Shimizu S, Eguchi Y, Tsujimoto Y, Nozawa Y. Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation. J Biol Chem. 1998.03; 273 (12): 6921-6927. ( PubMed )

  153. Shimizu S, Eguchi Y, Kamiike W, Funahashi Y, Mignon A, Lacronique V, Matsuda H, Tsujimoto Y. Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux. Proc Natl Acad Sci USA. 1998.02; 95 (4): 1455-1459. ( PubMed )

  154. Yamabe K, Shimizu S, Kamiike W, Waguri S, Eguchi Y, Hasegawa J, Okuno S, Yoshioka Y, Ito T, Sawa Y, Uchiyama Y, Tsujimoto Y, Matsuda H. Prevention of hypoxic liver cell necrosis by in vivo human bcl-2 gene transfection. Biochem Biophys Res Commun. 1998.02; 243 (1): 217-223. ( PubMed )

  155. Shimizu S, Tsujimoto Y. [Molecular mechanism of apoptosis]. Seikagaku. 1998.01; 70 (1): 14-21. ( PubMed )

  156. Ohtsu M, Sakai N, Fujita H, Kashiwagi M, Gasa S, Shimizu S, Eguchi Y, Tsujimoto Y, Sakiyama Y, Kobayashi K, Kuzumaki N. Inhibition of apoptosis by the actin-regulatory protein gelsolin. EMBO J. 1997.08; 16 (15): 4650-4656. ( PubMed, DOI )

  157. Eguchi Y, Shimizu S, Tsujimoto Y. Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res. 1997.05; 57 (10): 1835-1840. ( PubMed )

  158. Shimizu S, Eguchi Y, Kamiike W, Akao Y, Kosaka H, Hasegawa J, Matsuda H, Tsujimoto Y. Involvement of ICE family proteases in apoptosis induced by reoxygenation of hypoxic hepatocytes. Am J Physiol. 1996.12; 271 (6 Pt 1): G949-58. ( PubMed )

  159. Morimoto Y, Kamiike W, Nishida T, Hatanaka N, Shimizu S, Huang TP, Hamada E, Uchiyama Y, Yoshida Y, Furuya E, Matsuda H. Improvement of rat liver graft function by insulin administration to donor. Gastroenterology. 1996.10; 111 (4): 1071-1080. ( PubMed )

  160. Shimizu S, Eguchi Y, Kamiike W, Waguri S, Uchiyama Y, Matsuda H, Tsujimoto Y. Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors. Oncogene. 1996.07; 13 (1): 21-29. ( PubMed )

  161. Shimizu S, Eguchi Y, Kamiike W, Matsuda H, Tsujimoto Y. Bcl-2 expression prevents activation of the ICE protease cascade. Oncogene. 1996.06; 12 (11): 2251-2257. ( PubMed )

  162. Shimizu S, Eguchi Y, Kamiike W, Itoh Y, Hasegawa J, Yamabe K, Otsuki Y, Matsuda H, Tsujimoto Y. Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL. Cancer Res. 1996.05; 56 (9): 2161-2166. ( PubMed )

  163. Shimizu S, Eguchi Y, Kamiike W, Waguri S, Uchiyama Y, Matsuda H, Tsujimoto Y. Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible involvement of common mediators in apoptotic and necrotic signal transductions. Oncogene. 1996.05; 12 (10): 2045-2050. ( PubMed )

  164. Hasegawa J, Kamada S, Kamiike W, Shimizu S, Imazu T, Matsuda H, Tsujimoto Y. Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis. Cancer Res. 1996.04; 56 (8): 1713-1718. ( PubMed )

  165. Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H, Tsujimoto Y. Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature. 1995.04; 374 (6525): 811-813. ( PubMed, DOI )

  166. Shimizu S, Kamiike W, Hatanaka N, Yoshida Y, Tagawa K, Miyata M, Matsuda H. New method for measuring ICG Rmax with a clearance meter. World J Surg. 1995; 19 (1): 113-8; discussion 118. ( PubMed )

  167. Fujikawa M, Kamiike W, Hatanaka N, Shimizu S, Akashi A, Miyata M, Kurosawa K, Yoshida Y, Tagawa K, Matsuda H. Changes in biliary glutathione level during ischemia-reperfusion of rat liver. J Surg Res. 1994.11; 57 (5): 569-573. ( PubMed, DOI )

  168. Shimizu S, Kamiike W, Hatanaka N, Miyata M, Inoue T, Yoshida Y, Tagawa K, Matsuda H. Beneficial effects of cyclosporine on reoxygenation injury in hypoxic rat liver. Transplantation. 1994.06; 57 (11): 1562-1566. ( PubMed )

  169. Hatanaka N, Kamiike W, Morimoto Y, Shimizu S, Miyata M, Yoshida Y, Matsuda H. Protective effects of feeding and of fructose against hypoxic damage in the perfused liver. Transplant Proc. 1994.04; 26 (2): 916-917. ( PubMed )

  170. Kamiike W, Miyata M, Izukura M, Itoh T, Nezu R, Nakamuro M, Hatanaka N, Shimizu S, Takahashi T, Shimazaki Y. Simultaneous surgery for coronary artery disease and gastric cancer. World J Surg. 1994; 18 (6): 879-81; discussion 882. ( PubMed )

  171. Ng SB, Ohshima K, Selvarajan V, Huang G, Choo SN, Miyoshi H, Shimizu N, Reghunathan R, Chua HC, Yeoh AE, Quah TC, Koh LP, Tan PL, Chng WJ. . Epstein-Barr virus-associated T/natural killer-cell lymphoproliferative disorder in children and young adults has similar molecular signature to extranodal nasal natural killer/T-cell lymphoma but shows distinctive stem cell-like phenotype. Leuk Lymphoma.. 56 2408-2415.

  172. Wu T, Wang S, Wu J, Lin Z, Sui X, Xu X, Shimizu N, Chen B, Wang X.. Icaritin induces lytic cytotoxicity in extranodal NK/T-cell lymphoma. J Exp Clin Cancer Res. . 34 17.

  173. Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S,Matsuura Y, Akira S, Saitoh T.. Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response. PNAS..

  174. Arakawa S, Honda S, Torii S, Tsujioka M, Shimizu S.. Monitoring of Atg5-independent Mitophagy. Methods in Molecular Biology,"Mitophagy".

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Books etc 【 display / non-display

  1. Shimizu S. Autophagic Cell Death and Cancer Chemotherapeutics. . Springer, Innovative Medicine : Basic Research and Development

Conference Activities & Talks 【 display / non-display

  1. Shimizu S. Mitophagy and alternative autophagy. The 13th Conference of Asian Society for Mitochondrial Reseach and Medicine 2016.10.31 Shinagawa

  2. shimizu s. Macroautophagy mediates elimination of mitochondria from embryonic reticulocytes. 第78回日本血液学会 2016.10.13 yokohama

  3. Shimizu S. Alterntive Autophagy is Essential for Neuronal Cell Maintenance. Brain Protein Aiging and Dementia Contorol International Workshop 2016.09.09 Nagoya

  4. Shimizu S. Identification of natural puroduct against fatty liver disease based on the induction of alternative autophagy. ICNIM2016 2016.07.15 Sapporo

  5. Shimizu S. Physiological Role of Atg5-independent macroautophagy (Shimizu S). The 16th Northeastern Asian Symposium. 2014.12.19 Busan Korea

  6. shigeomi shimizu. Molecular mechanisms and physiological roles of Atg5-independent autophagy. Australia-Japan Cell Death meeting 2018.05.21 Tokyo

  7. shigeomi shimizu. Molecular mechanisms and physiological roles of Atg5-independent autophagy. EMBO meeting "Lysosome" 2018.05.09 Naples

  8. shigeomi shimizu. Mechanisms and Biological Roles of Golgi Stress-induced Mitophagy. Keystone Symposia 2018.04.26

  9. shigeomi shimizu. Development of molecularly targeted anticancer agents based on the regulation of autophagic cell death. The 76th Annual Meeting of the Japanese Cancer Association 2017.09.30 Yokohama

  10. Shimizu S. Development of Molecularly Targeted Anticancer Agents Based on the Regulation of Autophagic Cell Death (Shimizu S). The Uehara Memorial Foundation Symposium 2014 2014.06.15 Tokyo Japan

  11. Shimizu S. Molecular Mechanisms of Alternative Macroautophagy (Shimizu S). Gordon research Conference 2014.03.17 Barga Italy

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  • New insights into the development of Parkinson's disease in the brain,2023.09

  • Hanging on for dear life,2023.04

  • Taking out the trash is essential for brain health,2020.11

  • How Cells Decide the Way They Want to Recycle Their Content,2020.05

  • Role for autophagic cellular degradation process in maintaining genomic stability,2016.11